CN104815294A - Traditional Chinese medicine oral solution for treating chronic gastritis and preparation method thereof - Google Patents
Traditional Chinese medicine oral solution for treating chronic gastritis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine oral solution for treating chronic gastritis and a preparation method thereof, relates to the technical field of treating chronic gastritis, and mainly solves the problem of high irritation of the existing medicines for treating chronic gastritis. Raw material medicines for preparing the oral solution comprise the following effective ingredients in parts by mass: 5-15 parts of ginseng, 5-25 parts of astragalus membranaceus, 10-30 parts of platycladi seeds, 6-16 parts of white atractylodes rhizome, 5-16 parts of rhizoma atractylodis, 4-17 parts of szechwan Chinaberry fruit, 6-15 parts of lysimachia christinae hance, 5-15 parts of curcuma sichuaensis, 6-17 parts of fructus amomi, 6-16 parts of medicated leaven, 4-18 parts of malt, 5-20 parts of pinellia ternata, 5-25 parts of rhizoma cyperi, 6-19 parts of pericarpium citri reticulatae, 3-18 parts of poria cocos, 4-19 parts of radix paeoniae rubra, 5-20 parts of cimicifugae foetidae, 6-19 parts of radix bupleuri, 5-20 parts of elecampane, 7-18 parts of poncirus trifoliate, 3-9 parts of liquorice, and 1-5 parts of bamboo fungus. The traditional Chinese medicine oral solution disclosed by the invention is capable of promoting the disappearance of gastritis symptoms, and achieves a total treatment effective rate of more than 98%.
Description
Technical field
The present invention relates to treatment gastritis technical field, specifically a kind of Chinese medicine oral liquid for the treatment of chronic gastritis and preparation method thereof.
Background technology
Psoriasis is as dermatosis, and morbidity does not have regularity, and be easy to recurrence, some patient loses confidence because of the recurrent exerbation of the state of an illness to treatment.Psoriasis is often divided into three types by the traditional Chinese medical science: rheumatism pattern of fever, often show as damp and hot heap soil or fertilizer over and around the roots and contain, venation is obstructed; Blood-heat type often shows as scorchingly hot penting up, strongly fragrant in blood system; Septic often shows as retention of damp-heat in the interior, scorchingly hot flourishing.Rheumatism pattern of fever common manifestation symptom is general of erythema, desquamation, fold place have humidity, erosion, joint congestion and swelling pain, body abdominal distention, indigestion and loss of appetite, yellow and greasy fur, red tongue, slippery and rapid pulse; Blood-heat type is more common in the phase of carrying out, and reveal any symptoms is that erythra occurs and develops rapidly, local flushing, newborn erythra constantly occurs, squama can not cover erythema, conscious pruritus, and has the diseases such as susceptible to lose temper due to restlessness, dry mouth and tougue, laryngopharynx swelling and pain, constipation, oliguria with reddish urine, red tongue with yellow fur; Septicopyemia type type can be periodic flare, and reveal any symptoms often occurs together heat, vexed xerostomia, constipation, oliguria with reddish urine, red tongue or in furrowed tongue, slippery and rapid pulse.Dialectical: retention of damp-heat in the interior, scorchingly hot flourishing.The psoriasic method of western medical treatment often adopts steroid hormone method, suppresses DNA class medicine, phototherapy, antitumor drug, can treat general hair style or the obstinate type in local psoriasis skin lesion, but these medicines at treatment psoriasis disease instant effect simultaneously, life-time service side effect increases, but drug withdrawal is easily recurred, and cannot effect a radical cure.
Summary of the invention
The object of the invention is to overcome the above problems, and provide while treating psoriasis, a kind of Chinese medicine oral liquid for the treatment of chronic gastritis little to gastrointestinal stimulation effect and preparation method thereof.
The technical solution used in the present invention is: a kind of Chinese medicine oral liquid for the treatment of chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 5 ~ 15 parts, the Radix Astragali 5 ~ 25 parts, Semen Platycladi 10 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 16 parts, Rhizoma Atractylodis 5 ~ 16 parts, Fructus Toosendan 4 ~ 17 parts, Herba Lysimachiae 6 ~ 15 parts, RADIX CURCUMAE from Sichuan of China 5 ~ 15 parts, Fructus Amomi 6 ~ 17 parts, Massa Medicata Fermentata 6 ~ 16 parts, 4 ~ 18 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 5 ~ 20 parts, Rhizoma Cyperi 5 ~ 25 parts, Pericarpium Citri Reticulatae 6 ~ 19 parts, 3 ~ 18 parts, Poria, Radix Paeoniae Rubra 4 ~ 19 parts, Rhizoma Cimicifugae 5 ~ 20 parts, Radix Bupleuri 6 ~ 19 parts, the Radix Aucklandiae 5 ~ 20 parts, Fructus Aurantii 7 ~ 18 parts, 3 ~ 9 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 1 ~ 5 part.
Further, a kind of Chinese medicine oral liquid for the treatment of chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 8 ~ 13 parts, the Radix Astragali 10 ~ 20 parts, Semen Platycladi 15 ~ 25 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Rhizoma Atractylodis 7 ~ 13 parts, Fructus Toosendan 7 ~ 14 parts, Herba Lysimachiae 9 ~ 13 parts, RADIX CURCUMAE from Sichuan of China 7 ~ 12 parts, Fructus Amomi 8 ~ 12 parts, Massa Medicata Fermentata 8 ~ 13 parts, 7 ~ 15 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 8 ~ 16 parts, Rhizoma Cyperi 10 ~ 20 parts, Pericarpium Citri Reticulatae 8 ~ 14 parts, 7 ~ 18 parts, Poria, Radix Paeoniae Rubra 7 ~ 14 parts, Rhizoma Cimicifugae 7 ~ 15 parts, Radix Bupleuri 8 ~ 16 parts, the Radix Aucklandiae 7 ~ 15 parts, Fructus Aurantii 9 ~ 13 parts, 5 ~ 7 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 2 ~ 4 parts.
Further, treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 11 parts, the Radix Astragali 15 parts, Semen Platycladi 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Atractylodis 10 parts, Fructus Toosendan 11 parts, Herba Lysimachiae 11 parts, RADIX CURCUMAE from Sichuan of China 9 parts, Fructus Amomi 10 parts, Massa Medicata Fermentata 10 parts, 11 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 10 parts, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 10 parts, 11 parts, Poria, Radix Paeoniae Rubra 11 parts, Rhizoma Cimicifugae 11 parts, Radix Bupleuri 11 parts, the Radix Aucklandiae 10 parts, Fructus Aurantii 10 parts, 6 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 3 parts.
Further, a kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis, preparation method is as follows:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40-50 DEG C is soaked 1h, obtains soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Instructions of taking: every day three times, a 250ml, half an hour ante cibum uses, and within 10 days, is a course for the treatment of.
Medical material effect of the present invention is resolved as follows:
Radix Ginseng sweet in the mouth, micro-hardship, warm in nature, flat.QI invigorating, Gu de-, promote the production of body fluid, calms the nerves, Fructus Alpiniae Oxyphyllae; Primary treatment weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung is breathed with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia, sexual impotence cold womb; Heart failure, cardiogenic shock.Radix Astragali sweet in the mouth, slightly warm in nature, function is the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, warming the lung to relieve cough, removing toxic substances.Semen Platycladi sweet in the mouth, property is flat has tranquilizing by nourishing the heart, effect of loosening bowel to relieve constipation, for restlessness of asrhenia type and insomnia, severe palpitation, the diseases such as dryness of the intestine constipation.Rhizoma Atractylodis Macrocephalae bitter in the mouth, sweet, warm in nature, have invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect, be mainly used in insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Rhizoma Atractylodis acrid in the mouth, hardship, warm in nature, have drying damp and strengthening spleen, expelling wind and cold, effect of improving eyesight, be mainly used in treating retention of dampness in middle-JIAO, distension and fullness in the abdomen, has loose bowels, edema, and beriberi flaccidity is knitted, and rheumatic arthralgia, anemofrigid cold, nyctalopia, eyes dusk is puckery.Fructus Toosendan bitter in the mouth, cold in nature, have soothing the liver expelling the heat-evil, promoting the circulation of QI to relieve pain, effect of parasite killing, is mainly used in pathogenic fire derived from stagnation of liver-QI, the breast side of body, abdominal distention, hernia pain, abdominal pain due to worm stagnation.Herba Lysimachiae sweet in the mouth, micro-hardship, cool in nature, be mainly used in relieving stranguria by diuresis, heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, cure mainly liver and gall and urinary system calculus, pyretic stranguria, oedema due to nephritis, jaundice due to damp-heat, sore carbuncle, venom, traumatic injury.RADIX CURCUMAE from Sichuan of China acrid in the mouth is bitter, and cold in nature, have regulating qi to disperse stagnation, heart fire-clearing upset-relieving, effect of promoting the function of the gallbladder to alleviate jaundice, for amenorrhea dysmenorrhea, chest and abdomen swelling and pain, twinge, calentura coma, epilepsy is gone mad, jaundice dark coloured urine.Fructus Amomi acrid in the mouth, property wets, and have removing dampness appetizing, warming spleen and stopping diarrha, antiabortive effect of regulating the flow of vital energy, for turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is not hungry, Deficiency and coldness of spleen and stomach, and vomiting is had loose bowels, pregnancy reactions, frequent fetal movement.Massa Medicata Fermentata sweet in the mouth, pungent, warm in nature, there is effect of invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, for retention of food and drink, dyspepsia, distension and fullness in the abdomen, inappetence, vomiting dysentery.Fructus Hordei Germinatus is put down, sweet in the mouth, energy digesting and appetizing, and in, galactopoiesis.Rhizoma Pinelliae acrid in the mouth, warm in nature, have drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, effect of dissolving lump and resolving mass, for damp-phlegm cold-phlegm, cough with asthma abundant expectoration, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm is had a headache, and vomiting regurgitation, breast gastral cavity painful abdominal mass is vexed, globus hystericus, external treatment carbuncle sucutaneous nodule.Rhizoma Cyperi acrid in the mouth, micro-hardship, micro-sweet, property is put down, and have dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, effect of menstruction regulating and pain relieving, for stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, distending pain of the breast, stagnation of QI in spleen and stomach, gastral cavity abdomen painful abdominal mass is vexed, distension pain, menoxenia, amenorrhea dysmenorrhea.Pericarpium Citri Reticulatae bitter in the mouth, warm in nature, function is regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, and modern study shows: Pericarpium Citri Reticulatae has gentle stimulation to gastrointestinal smooth muscle, the secretion of energy facilitating digestion liquid and elimination intestinal pneumatosis.Poria sweet in the mouth, light, property is put down, and has promoting diuresis to eliminate damp pathogen, spleen invigorating, effect of mind calming, and for edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Radix Paeoniae Rubra bitter in the mouth, cold nature, has clearing away heat and cooling blood, effect of eliminating stasis to stop pain, and for thermal man's nutrient blood, maculae caused by violent heat pathogen, hematemesis and epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, addiction abdominal mass is suffered from abdominal pain, injury from falling down, carbuncle skin infection.Rhizoma Cimicifugae acrid in the mouth, sweet, cold nature, has and delivers rash, heat-clearing and toxic substances removing, effect of ascending up spleen-Qi and Yang, is mainly used in seasonal epidemic pathogens epidemic disease, headache cold and heat, laryngalgia, aphtha, and macule is saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, and women is collapsed, band, and uterus drops, carbuncle sore tumefacting virus.Radix Bupleuri acrid in the mouth, hardship, cold nature, has reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, the effect of preventing the attack (or recurrence) of malaria of bringing down a fever, for cold, fever, alternate attack of chill and fever, distending pain in the chest and hypochondrium, menoxenia, uterine prolapse, proctoptosis.Radix Aucklandiae acrid in the mouth, hardship, warm in nature, have promoting the circulation of QI to relieve pain, effect of strengthening the spleen to promote digestion, for the breast side of body, abdominal distention, heavy after dysentery, food stagnation does not disappear, anorexia.Fructus Aurantii bitter in the mouth, cold nature, has regulating the flow of QI to ease the stomach, effect of the stagnant relieving distension of row, and it is stagnant to be mainly used in chest and diaphragm expectorant, and the feeling of stuffiness in chest, coerces swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Radix Glycyrrhizae sweet in the mouth, property are flat, and it contains number of chemical composition, and effect is replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, heat-clearing and toxic substances removing, relieving spasm to stop pain.Caulis Bambusae In Taenia sweet in the mouth, cold nature, has removing heat-phlegm, the effect relieved restlessness and prevented vomiting, and holds expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.
The present invention has following beneficial effect:
(1) ginseng qi-tonifying takes off admittedly, Radix Astragali warming middle-JIAO to arrest vomiting, Semen Platycladi tranquilizing by nourishing the heart, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI, Rhizoma Atractylodis are drying damp and strengthening spleen, Poria promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming, Radix Aucklandiae promoting the circulation of QI to relieve pain, strengthening the spleen to promote digestion, Radix Glycyrrhizae replenishing QI to invigorate the spleen, expelling phlegm for arresting cough, Drug is gentle, and effectively treatment is insufficiency of the spleen; Fructus Toosendan is soothing the liver to expel the heat-evil, promoting the circulation of QI to relieve pain, Herba Lysimachiae relieving stranguria by diuresis, heat-clearing and toxic substances removing, RADIX CURCUMAE from Sichuan of China regulating qi to disperse stagnation, promoting the function of the gallbladder to alleviate jaundice, and Caulis Bambusae In Taenia removing heat-phlegm, relieves restlessness and prevents vomiting, can effective circulation of qi promoting profit liver, and treatment regurgitation causes having the hiccups the symptom of belch; Fructus Amomi removing dampness is whetted the appetite, warming spleen and stopping diarrha, Massa Medicata Fermentata invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation, Fructus Hordei Germinatus energy digesting and appetizing, Fructus Aurantii regulating the flow of QI to ease the stomach, the stagnant relieving distension of row, can effective invigorating the spleen and regulating the stomach, promoting digestion and removing stagnation; Rhizoma Pinelliae drying dampness to eliminate phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, Rhizoma Cyperi dispersing the stagnated live-QI to relieve the stagnation of QI, regulating the flow of QI to ease the stomach, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Radix Paeoniae Rubra clearing away heat and cooling blood, eliminating stasis to stop pain, rash delivered by Rhizoma Cimicifugae, heat-clearing and toxic substances removing, Radix Bupleuri has reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, the secretion of energy facilitating digestion liquid and elimination intestinal pneumatosis, drug matching is suitable for, little to stomach irritation, and medical material is easy to get.
(2) first a period of time is soaked by purified water, medical material deliquescing, cell expansion before decoction, effective ingredient is easily fried, and medical material contains starch, protein, after soaking, prevent when decocting, the starch gelatinization on medical material surface, protein coagulating, the capillary channel on blocking medical material surface, makes the moisture when decocting enter not go, effective ingredient is not easily fried, affects curative effect of medication; Decoction can change the irritation effect of medicine, relatively mildly acts on stomach, alleviates stomach discomfort, promotes the absorption of medicine; Supercritical extraction, immersion, concentration step retain the effective ingredient in Chinese medicine of the present invention to greatest extent, thus the quality improving oral liquid reaches refining object.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is further elaborated.
Embodiment 1:
Treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 5 parts, the Radix Astragali 5 parts, Semen Platycladi 10 parts, the Rhizoma Atractylodis Macrocephalae 6 parts, Rhizoma Atractylodis 5 parts, Fructus Toosendan 4 parts, Herba Lysimachiae 6 parts, RADIX CURCUMAE from Sichuan of China 5 parts, Fructus Amomi 6 parts, Massa Medicata Fermentata 6 parts, 4 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 5 parts, Rhizoma Cyperi 5 parts, Pericarpium Citri Reticulatae 6 parts, 3 parts, Poria, Radix Paeoniae Rubra 4 parts, Rhizoma Cimicifugae 5 parts, Radix Bupleuri 6 parts, the Radix Aucklandiae 5 parts, Fructus Aurantii 7 parts, 3 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 1 part.
A kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40 DEG C are soaked 1h, obtain soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Embodiment 2:
Treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 15 parts, the Radix Astragali 25 parts, Semen Platycladi 30 parts, the Rhizoma Atractylodis Macrocephalae 16 parts, Rhizoma Atractylodis 16 parts, Fructus Toosendan 17 parts, Herba Lysimachiae 15 parts, RADIX CURCUMAE from Sichuan of China 15 parts, Fructus Amomi 17 parts, Massa Medicata Fermentata 16 parts, 18 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 20 parts, Rhizoma Cyperi 25 parts, Pericarpium Citri Reticulatae 19 parts, 18 parts, Poria, Radix Paeoniae Rubra 19 parts, Rhizoma Cimicifugae 20 parts, Radix Bupleuri 19 parts, the Radix Aucklandiae 20 parts, Fructus Aurantii 18 parts, 9 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 5 parts.
A kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 45 DEG C are soaked 1h, obtain soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Embodiment 3:
Treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 8 parts, the Radix Astragali 10 parts, Semen Platycladi 15 parts, the Rhizoma Atractylodis Macrocephalae 8 parts, Rhizoma Atractylodis 7 parts, Fructus Toosendan 7 parts, Herba Lysimachiae 9 parts, RADIX CURCUMAE from Sichuan of China 7 parts, Fructus Amomi 8 parts, Massa Medicata Fermentata 8 parts, 7 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 8 parts, Rhizoma Cyperi 10 parts, Pericarpium Citri Reticulatae 8 parts, 7 parts, Poria, Radix Paeoniae Rubra 7 parts, Rhizoma Cimicifugae 7 parts, Radix Bupleuri 8 parts, the Radix Aucklandiae 7 parts, Fructus Aurantii 9 parts, 5 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 2 parts.
A kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Embodiment 4:
Treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 13 parts, the Radix Astragali 20 parts, Semen Platycladi 25 parts, the Rhizoma Atractylodis Macrocephalae 12 parts, Rhizoma Atractylodis 13 parts, Fructus Toosendan 14 parts, Herba Lysimachiae 13 parts, RADIX CURCUMAE from Sichuan of China 12 parts, Fructus Amomi 12 parts, Massa Medicata Fermentata 13 parts, 15 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 16 parts, Rhizoma Cyperi 20 parts, Pericarpium Citri Reticulatae 14 parts, 18 parts, Poria, Radix Paeoniae Rubra 14 parts, Rhizoma Cimicifugae 15 parts, Radix Bupleuri 16 parts, the Radix Aucklandiae 15 parts, Fructus Aurantii 13 parts, 7 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 4 parts.
A kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40 DEG C are soaked 1h, obtain soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.14;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Embodiment 5:
Treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 11 parts, the Radix Astragali 15 parts, Semen Platycladi 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Atractylodis 10 parts, Fructus Toosendan 11 parts, Herba Lysimachiae 11 parts, RADIX CURCUMAE from Sichuan of China 9 parts, Fructus Amomi 10 parts, Massa Medicata Fermentata 10 parts, 11 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 10 parts, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 10 parts, 11 parts, Poria, Radix Paeoniae Rubra 11 parts, Rhizoma Cimicifugae 11 parts, Radix Bupleuri 11 parts, the Radix Aucklandiae 10 parts, Fructus Aurantii 10 parts, 6 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 3 parts.
A kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40 DEG C are soaked 1h, obtain soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.14;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Embodiment 6:
Treat a Chinese medicine oral liquid for chronic gastritis, the crude drug effective ingredient mass fraction making oral liquid comprises: Radix Ginseng 10 parts, the Radix Astragali 15 parts, Semen Platycladi 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Atractylodis 10 parts, Fructus Toosendan 10 parts, Herba Lysimachiae 10 parts, RADIX CURCUMAE from Sichuan of China 10 parts, Fructus Amomi 10 parts, Massa Medicata Fermentata 10 parts, 10 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 10 parts, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 10 parts, 10 parts, Poria, Radix Paeoniae Rubra 10 parts, Rhizoma Cimicifugae 10 parts, Radix Bupleuri 10 parts, the Radix Aucklandiae 10 parts, Fructus Aurantii 10 parts, 6 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 3 parts.
A kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 50 DEG C are soaked 1h, obtain soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.14;
(5) add 1000ml purified water in the extractum obtained to step (3), after high temperature sterilization, subpackage both.
Medicine of the present invention has carried out zoopery and clinical research, and its result is described below:
1, zoopery
Animal acute toxicity experiment, selects white mice 40, each 20 of male and female, sodium carboxymethyl cellulose solution with 1% makes the suspension of 50mg/ml, gavage body 0.56ml/10g, every day three times, observe animal activity after gavage 15 days, diet, feces, hair color and death condition, the results are shown in Table 1.
Animal acute toxicity experiment result:
Table 1
After experimental result gavage, the diet of animal, feces, none example of hair are abnormal, and after second, third gavage, much more slightly animal moves, and within about 10 minutes, the many emotionally conditions of animal disappear, and none example was dead on 15th.
Conclusion: maximum tolerated dose is ﹥ 7.35mg/kg is 147 times of the clinical maximal dose of people.
2, clinical data and case:
In order to show therapeutic effect of the present invention, system clinical observation treatment being carried out to 100 routine Patients with Chronic Gastritis, in the process of above-mentioned clinical observation, record being carried out to the medical history of above-mentioned patient, the state of an illness and curative effect.
Clinical therapeutic efficacy criterion is:
Cure: glutted after burning sensation under common symptom acid regurgitation, belch, anorexia, Nausea and vomiting, xiphoid-process, food, epigastric discomfort or pain, thick fur are greasy, rolling pulse etc. all disappears.
Take a turn for the better: glutted after burning sensation under common sympton acid regurgitation, belch, anorexia, Nausea and vomiting, xiphoid-process, food, epigastric discomfort or pain, thick fur are greasy, rolling pulse etc. is basic disappears.
Invalid: symptom is not improved.
Therapeutic effect: the present invention is through treating 100 routine Patients with Chronic Gastritis, and 98 examples take a turn for the better, and 2 examples are invalid, and total effective rate reaches 98%, and nobody occurs side effect.
Model case:
Case 1: patient Jiang so-and-so, man, 29 years old, burning sensation under patient's acid regurgitation, belch, anorexia, Nausea and vomiting, xiphoid-process, after using 1 course for the treatment of of Chinese medicine oral liquid of the present invention, symptom obviously alleviated, 1 course for the treatment of of continuation use, and symptom all disappears.
Case 2: patient Lee, man, 48 years old, glutted after burning sensation under patient's Nausea and vomiting, xiphoid-process, food, epigastric discomfort or pain, thick fur are greasy, rolling pulse, and after using 2 courses for the treatment of of Chinese medicine oral liquid of the present invention, symptom is obviously improved, continue 2 courses for the treatment of of use, symptom all disappears.
Case 3: patient Jiang, female, 37 years old, glutted after burning sensation under patient's acid regurgitation, belch, anorexia, Nausea and vomiting, xiphoid-process, food, epigastric discomfort or pain, after using 1 course for the treatment of of Chinese medicine oral liquid of the present invention, symptom is clearly better, and after continuing to use 2 courses for the treatment of of Chinese medicine oral liquid of the present invention, symptom all disappears.
The above is the preferred embodiment of the present invention; its object is to allow person skilled in the art understand content of the present invention and to be implemented; should be understood that; for those skilled in the art; under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications are also considered as protection scope of the present invention.
Claims (4)
1. treat the Chinese medicine oral liquid of chronic gastritis for one kind, it is characterized in that, the crude drug effective ingredient mass fraction making gastritis comprises: Radix Ginseng 5 ~ 15 parts, the Radix Astragali 5 ~ 25 parts, Semen Platycladi 10 ~ 30 parts, the Rhizoma Atractylodis Macrocephalae 6 ~ 16 parts, Rhizoma Atractylodis 5 ~ 16 parts, Fructus Toosendan 4 ~ 17 parts, Herba Lysimachiae 6 ~ 15 parts, RADIX CURCUMAE from Sichuan of China 5 ~ 15 parts, Fructus Amomi 6 ~ 17 parts, Massa Medicata Fermentata 6 ~ 16 parts, 4 ~ 18 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 5 ~ 20 parts, Rhizoma Cyperi 5 ~ 25 parts, Pericarpium Citri Reticulatae 6 ~ 19 parts, 3 ~ 18 parts, Poria, Radix Paeoniae Rubra 4 ~ 19 parts, Rhizoma Cimicifugae 5 ~ 20 parts, Radix Bupleuri 6 ~ 19 parts, the Radix Aucklandiae 5 ~ 20 parts, Fructus Aurantii 7 ~ 18 parts, 3 ~ 9 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 1 ~ 5 part.
2. a kind of Chinese medicine oral liquid for the treatment of chronic gastritis according to claim 1, it is characterized in that, the crude drug effective ingredient mass fraction making gastritis comprises: Radix Ginseng 8 ~ 13 parts, the Radix Astragali 10 ~ 20 parts, Semen Platycladi 15 ~ 25 parts, the Rhizoma Atractylodis Macrocephalae 8 ~ 12 parts, Rhizoma Atractylodis 7 ~ 13 parts, Fructus Toosendan 7 ~ 14 parts, Herba Lysimachiae 9 ~ 13 parts, RADIX CURCUMAE from Sichuan of China 7 ~ 12 parts, Fructus Amomi 8 ~ 12 parts, Massa Medicata Fermentata 8 ~ 13 parts, 7 ~ 15 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 8 ~ 16 parts, Rhizoma Cyperi 10 ~ 20 parts, Pericarpium Citri Reticulatae 8 ~ 14 parts, 7 ~ 18 parts, Poria, Radix Paeoniae Rubra 7 ~ 14 parts, Rhizoma Cimicifugae 7 ~ 15 parts, Radix Bupleuri 8 ~ 16 parts, the Radix Aucklandiae 7 ~ 15 parts, Fructus Aurantii 9 ~ 13 parts, 5 ~ 7 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 2 ~ 4 parts.
3. a kind of Chinese medicine oral liquid for the treatment of chronic gastritis according to claim 1, it is characterized in that, the crude drug effective ingredient mass fraction making gastritis comprises: Radix Ginseng 11 parts, the Radix Astragali 15 parts, Semen Platycladi 20 parts, the Rhizoma Atractylodis Macrocephalae 10 parts, Rhizoma Atractylodis 10 parts, Fructus Toosendan 11 parts, Herba Lysimachiae 11 parts, RADIX CURCUMAE from Sichuan of China 9 parts, Fructus Amomi 10 parts, Massa Medicata Fermentata 10 parts, 11 parts, Fructus Hordei Germinatus, the Rhizoma Pinelliae 10 parts, Rhizoma Cyperi 15 parts, Pericarpium Citri Reticulatae 10 parts, 11 parts, Poria, Radix Paeoniae Rubra 11 parts, Rhizoma Cimicifugae 11 parts, Radix Bupleuri 11 parts, the Radix Aucklandiae 10 parts, Fructus Aurantii 10 parts, 6 parts, Radix Glycyrrhizae, Caulis Bambusae In Taenia 3 parts.
4. a kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic gastritis according to any one of claim 1-3, it is characterized in that, preparation process is as follows:
(1) soak: take each raw material by above-mentioned mass fraction, gross weight is designated as 1 part, adds 6 parts of purified water, 40-50 DEG C is soaked 1h, obtains soak;
(2) decoct: after the soak that step (1) obtains being heated to boiling, boil 2h, be separated and take out fried liquid, continue the purified water adding 4 parts in medical material, continue to boil 1.5h after being heated to boiling, merge twice fried liquid and be extracting solution;
(3) supercritical extraction: the extracting solution that step (2) obtains is positioned in the extraction kettle in supercritical extraction instrument, carbon dioxide is utilized to extract as medium, extraction kettle pressure is 40Mpa, extraction temperature is 45 DEG C, separator pressure 12Mpa, separator temperature is 70 DEG C, extracts 2 hours, is extracted liquid;
(4) concentrated: extract step (3) obtained concentrates at outer circulation concentrator, and concentrated condition is: pressure 0.03Mpa, temperature 70 C, is concentrated into the extractum that relative density is 1.13 ~ 1.14;
(5) add 1000ml purified water in the extractum obtained to step (4), after high temperature sterilization, subpackage both.
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Application publication date: 20150805 |