CN111686198A - Chinese herbal medicine composition for treating senile dementia and preparation method thereof - Google Patents
Chinese herbal medicine composition for treating senile dementia and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to the technical field of medicine preparation, and discloses a Chinese herbal medicine composition for treating senile dementia and a preparation method thereof, wherein the Chinese herbal medicine composition for treating senile dementia comprises, by mass, 4-7 parts of ginseng, 6-8 parts of wolfberry, 3-4 parts of astragalus membranaceus, 4-5 parts of angelica sinensis, 6-8 parts of kudzu vine root, 1-3 parts of epimedium herb, 4-6 parts of maca, 2-3 parts of rhizoma polygonati, 4-5 parts of red dates, 2-5 parts of Chinese yam and 1-2 parts of liquorice. The health-care tea takes ginseng, medlar, astragalus mongholicus, angelica sinensis, radix puerariae, herba epimedii, maca, rhizoma polygonati, red dates, Chinese yam and liquorice as main raw materials, ensures the supplement of nutrients required in a human body, can enhance the resistance, tonify the kidney and strengthen the brain, tonify the middle-jiao and qi, nourish the blood and tranquilize the mind, and has obvious effects on preventing and treating mild and moderate senile dementia; the preparation method of the medicine can fully preserve the effective components in the medicinal materials and has better treatment effect on mild and moderate senile dementia.
Description
Technical Field
The invention belongs to the technical field of medicine preparation, and particularly relates to a Chinese herbal medicine composition for treating senile dementia and a preparation method thereof.
Background
At present, senile dementia also known as Alzheimer Disease (AD) is a progressive degenerative disease of the nervous system with hidden disease. Clinically, the overall dementia such as dysmnesia, aphasia, disuse, agnosia, impairment of visual spatial skills, dysfunction in execution, and personality and behavior changes are characterized, and the etiology is unknown. Because the pathological change process of the senile dementia is quite complex and involves the abnormality of multiple systems and multiple targets, at present, no medicine for effectively treating the senile dementia exists.
Through the above analysis, the problems and defects of the prior art are as follows: at present, no medicine for effectively treating the senile dementia exists.
Disclosure of Invention
Aiming at the problems in the prior art, the invention provides a Chinese herbal medicine composition for treating senile dementia and a preparation method thereof.
The invention is realized in such a way that the preparation method of the Chinese herbal medicine composition for treating the senile dementia comprises the following steps:
step one, ginseng, medlar, astragalus, angelica, kudzu root, epimedium, maca, rhizoma polygonati, red date, Chinese yam and liquorice are respectively subjected to impurity removal, cleaning and air drying treatment.
And step two, respectively placing the astragalus, the angelica and the radix puerariae processed in the step one into a grinder for superfine grinding to respectively obtain astragalus powder, angelica powder and radix puerariae powder.
Step three, putting the red dates processed in the step one into a pot for frying, and stopping frying when the fragrance of the red dates is fried and the skins of the red dates begin to fall off in a granular manner; removing kernel of the fried red dates, and cutting the pulp of the red dates into red date strips for later use.
And step four, mixing the wolfberry fruits and the liquorice which are processed in the step one and the jujube kernels which are prepared in the step three, putting the mixture into a frying pan, adding water to immerse the medicinal materials for 6-8 hours, and then decocting and filtering the mixture.
Step five, adding the red date strips prepared in the step three into the filter residue obtained by filtering in the step four, adding water, continuously decocting, keeping the temperature at 90-100 ℃, continuously heating for 2-3 hours, filtering decoction, and combining the two filtrates; and concentrating the obtained filtrate under reduced pressure to obtain a mixed concentrated solution.
Sixthly, peeling the Chinese yam processed in the step one, cutting the Chinese yam pulp into Chinese yam dices with the thickness of 1cm by 1cm, placing the Chinese yam dices into a dryer for drying until the water content of the Chinese yam dices is lower than 10%, and taking out the Chinese yam dices; and (4) rolling and crushing the dried Chinese yam dices to obtain Chinese yam fine powder.
Step seven, rolling the whole herb of the epimedium herb to obtain epimedium herb slurry with coexisting solid and liquid; adding 70% ethanol with the mass 8-10 times of that of the epimedium herb slurry into an extraction device, heating and extracting for 4-6 hours, and concentrating until the relative density is 1.10-1.20 to obtain thick paste A.
Step eight, diluting the thick paste A with water, then loading the diluted thick paste A to a macroporous adsorption resin column, eluting with distilled water and 85 v/v% ethanol in sequence, collecting 85 v/v% ethanol eluent, recovering ethanol, and concentrating until the relative density is 1.10-1.20 to obtain thick paste B.
Step nine, after extraction is finished, diluting the thick paste B with water, and then performing DAC chromatographic separation and elution; collecting eluent of 28-40 min, and decompressing and concentrating the eluent to 1/3 of the volume of the initial mixed liquid; spray drying to obtain herba Epimedii extract granule.
Step ten, cutting the ginseng into thick pieces with the thickness of 0.2-0.3 cm, and placing the thick pieces in an extraction device; adding ethanol into the leaching device for reflux leaching; and filtering the leaching liquor after leaching to remove solid impurities and obtain clear liquid.
Step eleven, slowly heating the obtained clear liquid at 40-60 ℃, and stopping heating after the ethanol is completely volatilized to obtain a ginseng extracting solution; continuously heating the ginseng extract at 40-50 ℃, and evaporating water to dryness; drying the ginseng extract and the filter residue obtained by filtering, grinding, and sieving with a 100-mesh sieve to obtain the ginseng extract.
Step twelve, respectively preparing a maca extract and a polygonatum extract from the maca and the polygonatum processed in the step one; mixing the prepared radix astragali powder, radix Angelicae sinensis powder, radix Puerariae powder, mixed concentrated solution, herba Epimedii extract, Ginseng radix extract, Lepidium Meyenii Walp extract and rhizoma Polygonati extract to obtain mixture.
Step thirteen, placing the mixture prepared in the step twelve into a mould, and placing the mould into a drying box for drying; taking down the mould to obtain a sheet preparation, and carrying out aseptic packaging to obtain the Chinese herbal medicine composition for treating senile dementia.
Further, in the second step, the grain diameters of the astragalus powder, the angelica powder and the kudzu root powder are less than 20 microns.
Further, in the fifth step, the decocting conditions are as follows: heating at 80-85 ℃ for 10-20 min, heating at 150-160 ℃ for 30-35 min after water is boiled, and then cooling to 60 ℃ for heating for 2-4 h.
Further, in the ninth step, the vacuum concentration specifically comprises: setting the pressure to be 2.0-2.5 kPa, the temperature of the filtrate to be 70-75 ℃, and the concentration time to be 20-30 min, and carrying out reduced pressure concentration on the filtrate.
Further, in the ninth step, the DAC column is 250 multiplied by 600mm in size, the filler is C18, and the particle size is 10-15 μm.
Further, in the ninth step, the flow rate of the elution is 250-300 mL/min; the detection wavelength is 270-300 nm; the column pressure is 10-15 Mpa.
Further, in the twelfth step, the preparation method of the maca extract comprises the following steps:
(I) airing the treated maca until the maca is dry, wherein the water content is not more than 5%; crushing the aired maca into mud residue in a crusher;
(II) soaking the sludge-shaped maca in 70% ethanol for 3-4 days to obtain a maca mixture;
(III) putting the soaked maca mixture into a spin dryer for spin-drying separation, and canning the effluent liquid;
(IV) standing the liquid in the tank for 3-5 h, and filtering out the supernatant to obtain the maca extract.
Further, in the twelfth step, the preparation method of the polygonatum sibiricum extract comprises the following steps:
(1) putting the treated rhizoma polygonati into a leaching device, adding 70% ethanol for reflux leaching to obtain a leaching solution;
(2) removing solid impurities in the leaching liquor to obtain clear liquid;
(3) slowly heating the obtained clear liquid at the temperature of 40-60 ℃;
(4) stopping heating after the ethanol is completely volatilized, and cooling to obtain the rhizoma polygonati extract.
Further, in the thirteenth step, the drying in the drying box specifically comprises: and (3) putting the mould with the mixture into a drying box, setting the drying temperature to be 30-40 ℃ and the drying time to be 24-28 h.
The invention also aims to provide the Chinese herbal medicine composition for treating senile dementia, which is prepared by applying the preparation method of the Chinese herbal medicine composition for treating senile dementia, and the Chinese herbal medicine composition for treating senile dementia is composed of 4-7 parts of ginseng, 6-8 parts of wolfberry fruit, 3-4 parts of astragalus membranaceus, 4-5 parts of angelica sinensis, 6-8 parts of kudzu vine root, 1-3 parts of epimedium, 4-6 parts of maca, 2-3 parts of rhizoma polygonati, 4-5 parts of red dates, 2-5 parts of Chinese yam and 1-2 parts of liquorice in parts by mass.
By combining all the technical schemes, the invention has the advantages and positive effects that: the health-care tea takes ginseng, medlar, astragalus mongholicus, angelica sinensis, radix puerariae, herba epimedii, maca, rhizoma polygonati, red dates, Chinese yam and liquorice as main raw materials, ensures the supplement of nutrients required in a human body, can enhance the resistance, tonify the kidney and strengthen the brain, tonify the middle-jiao and qi, nourish the blood and tranquilize the mind, and has obvious effects on preventing and treating mild and moderate senile dementia; the preparation method of the medicine can fully preserve the effective components in the medicinal materials and has better treatment effect on mild and moderate senile dementia.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present application, the drawings needed to be used in the embodiments of the present application will be briefly described below, and it is obvious that the drawings described below are only some embodiments of the present application, and it is obvious for those skilled in the art that other drawings can be obtained from the drawings without creative efforts.
FIG. 1 is a flow chart of the preparation method of the Chinese herbal medicine composition for treating senile dementia provided by the embodiment of the invention.
FIG. 2 is a flow chart of the preparation method of Epimedium extract according to the embodiment of the present invention.
FIG. 3 is a flow chart of a method for preparing a ginseng extract according to an embodiment of the present invention.
Fig. 4 is a flow chart of a preparation method of the maca extract provided by the embodiment of the invention.
FIG. 5 is a flow chart of a method for preparing an extract of Polygonatum sibiricum Red.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Aiming at the problems in the prior art, the invention provides a Chinese herbal medicine composition for treating senile dementia and a preparation method thereof, and the invention is described in detail with reference to the accompanying drawings.
As shown in fig. 1, the preparation method of the Chinese herbal medicine composition for treating senile dementia provided by the embodiment of the invention comprises the following steps:
s101, respectively removing impurities from ginseng, wolfberry fruit, astragalus membranaceus, angelica sinensis, radix puerariae, herba epimedii, maca, rhizoma polygonati, red dates, Chinese yam and liquorice, cleaning and airing.
And S102, respectively placing the astragalus, the angelica and the radix puerariae processed in the step S101 into a grinder for superfine grinding to respectively obtain astragalus powder, angelica powder and radix puerariae powder.
S103, putting the red dates processed in the step S101 into a pot for frying, and stopping frying when the fragrance of the red dates is fried and the skins of the red dates begin to fall off in a granular manner; removing kernel of the fried red dates, and cutting the pulp of the red dates into red date strips for later use.
And S104, mixing the wolfberry fruits and the liquorice which are processed in the step S101 and the jujube kernels which are prepared in the step S103, putting the mixture into a frying pan, adding water to immerse the medicinal materials for 6-8 hours, decocting and filtering.
S105, adding the red jujube strips prepared in the S103 into filter residues obtained by filtering in the S104, adding water, continuously decocting, keeping the temperature at 90-100 ℃, continuously heating for 2-3 hours, filtering decoction, and combining filtrates; and concentrating the obtained filtrate under reduced pressure to obtain a mixed concentrated solution.
S106, peeling the Chinese yam processed in the step S101, cutting the Chinese yam pulp into Chinese yam dices with the thickness of 1cm by 1cm, placing the Chinese yam dices in a dryer for drying until the water content of the Chinese yam dices is lower than 10%, and taking out the Chinese yam dices; and (4) rolling and crushing the dried Chinese yam dices to obtain Chinese yam fine powder.
S107, respectively using the epimedium herb, the ginseng, the maca and the sealwort processed in the step S101 to prepare an epimedium herb extract, a ginseng extract, a maca extract and a sealwort extract.
S108, mixing the astragalus powder, the angelica powder and the radix puerariae powder prepared in the step S102, the mixed concentrated solution prepared in the step S105, the epimedium extract prepared in the step S107, the ginseng extract, the maca extract and the sealwort extract to obtain a mixture.
S109, placing the mixture prepared in the step S108 into a mold, and placing the mold into a drying box for drying; taking down the mold to obtain a sheet preparation, and carrying out aseptic packaging to obtain the Chinese herbal medicine composition for treating senile dementia.
In step S102 provided in the embodiment of the present invention, the particle sizes of the astragalus powder, the angelica powder, and the pueraria powder are less than 20 μm.
In step S104 provided in the embodiment of the present invention, the decocting conditions are as follows: heating at 80-85 ℃ for 10-20 min, heating at 150-160 ℃ for 30-35 min after water is boiled, and then cooling to 60 ℃ for heating for 2-4 h.
In step S105 provided in the embodiment of the present invention, the performing vacuum concentration specifically includes: setting the pressure to be 2.0-2.5 kPa, the temperature of the filtrate to be 70-75 ℃, and the concentration time to be 20-30 min, and carrying out reduced pressure concentration on the filtrate.
As shown in fig. 2, in step S107 provided by the embodiment of the present invention, the preparation method of the epimedium extract includes:
s201, rolling the whole herb of epimedium to obtain epimedium serous fluid with coexisting solid and liquid; adding 70% ethanol with the mass 8-10 times of that of the epimedium herb slurry into an extraction device, heating and extracting for 4-6 hours, and concentrating until the relative density is 1.10-1.20 to obtain thick paste A.
S202, diluting the thick paste A with water, then loading the diluted thick paste A to a macroporous adsorption resin column, eluting with distilled water and 85 v/v% ethanol in sequence, collecting 85 v/v% ethanol eluent, recovering ethanol, and concentrating until the relative density is 1.10-1.20 to obtain thick paste B.
S203, diluting the thick paste B with water after extraction, and then performing DAC chromatographic separation and elution; collecting eluent of 28-40 min, and decompressing and concentrating the eluent to 1/3 of the volume of the initial mixed liquid; spray drying to obtain herba Epimedii extract granule.
In step S203 provided by the embodiment of the present invention, the DAC column has a size of 250 × 600mm, the filler is C18, and the particle size is 10 to 15 μm.
In step S203 provided in the embodiment of the present invention, the flow rate of the elution is 250 to 300 mL/min; the detection wavelength is 270-300 nm; the column pressure is 10-15 Mpa.
As shown in fig. 3, in step S107 provided in the embodiment of the present invention, the preparation method of the ginseng extract includes:
s301, cutting the ginseng into thick pieces with the thickness of 0.2-0.3 cm, and placing the thick pieces in an extraction device; adding ethanol into the leaching device for reflux leaching.
And S302, filtering the leaching liquor after leaching, and filtering solid impurities to obtain clear liquid.
S303, slowly heating the obtained clear liquid at 40-60 ℃, and stopping heating after the ethanol is completely volatilized to obtain the ginseng extracting solution.
S304, continuously heating the ginseng extracting solution at 40-50 ℃, and evaporating water to dryness; drying the ginseng extract and the filter residue obtained by filtering, grinding, and sieving with a 100-mesh sieve to obtain the ginseng extract.
As shown in fig. 4, in step S107 provided in the embodiment of the present invention, the preparation method of the maca extract includes:
s401, airing the treated maca until the maca is dry, wherein the water content is not more than 5%; and crushing the aired maca into mud residue in a crusher.
S402, soaking sludge-shaped maca in 70% ethanol for 3-4 days to obtain a maca mixture; and (4) putting the soaked maca mixture into a spin dryer for spin-drying separation, and canning the effluent liquid.
And S403, standing the liquid in the tank for 3-5 hours, and filtering out supernatant liquid to obtain the maca extract.
As shown in fig. 5, in step S107 provided in the embodiment of the present invention, the preparation method of the polygonatum sibiricum extract includes:
s501, placing the processed rhizoma polygonati into a leaching device, adding 70% ethanol for reflux leaching to obtain a leaching solution.
S502, removing solid impurities in the leaching liquor to obtain clear liquid; and slowly heating the obtained clear liquid at the temperature of 40-60 ℃.
And S503, stopping heating after the ethanol is completely volatilized, and cooling to obtain the sealwort extract.
In step S109 provided in the embodiment of the present invention, the step of placing into a drying oven for drying specifically includes: and (3) putting the mould with the mixture into a drying box, setting the drying temperature to be 30-40 ℃ and the drying time to be 24-28 h.
The Chinese herbal medicine composition for treating senile dementia, which is provided by the embodiment of the invention, comprises, by mass, 4-7 parts of ginseng, 6-8 parts of wolfberry fruit, 3-4 parts of astragalus membranaceus, 4-5 parts of angelica sinensis, 6-8 parts of radix puerariae, 1-3 parts of epimedium herb, 4-6 parts of maca, 2-3 parts of rhizoma polygonati, 4-5 parts of red dates, 2-5 parts of Chinese yam and 1-2 parts of liquorice.
The invention is further described below in connection with pharmacological assays.
Ginseng is sweet and slightly bitter in taste, warm and mild in nature. It enters spleen, lung and heart meridians. Tonify qi, secure collapse, promote fluid production, induce tranquilization, and promote intelligence. The main indications are body deficiency and desire to loose, cold limbs and a little pulse, spleen deficiency and poor appetite, lung deficiency and cough, body fluid deficiency and thirst, internal heat and diabetes, deficiency with asthenia caused by chronic diseases, palpitation and insomnia, impotence and cold womb; heart failure, cardiogenic shock. Can be used for treating short breath, dyspnea, palpitation, amnesia, thirst, hyperhidrosis, anorexia, asthenia, acute and chronic diseases, and shock and collapse caused by blood loss. Tonify primordial qi, relieve depletion and promote fluid production, induce tranquilization. It is indicated for deficiency due to overstrain, poor appetite, lassitude, regurgitation, diarrhea, cough, dyspnea, spontaneous sweating, palpitation, amnesia, vertigo, headache, impotence, frequent micturition, diabetes, metrorrhagia, metrostaxis, chronic infantile convulsion, and deficiency of both qi and blood.
Fructus Lycii, also known as fructus Lycii and herba Polygoni Cymosi, is the mature seed of fructus Lycii, shrub of Solanaceae. The medlar has a long history of homology of medicine and food, is a rare Chinese medicinal material in China and abroad, is listed as a superior product in Shen nong's herbal classic, and is called as ' long-time taking, light weight, no aging, cold resistance and summer heat resistance '; has the functions of delaying senility and resisting senility, and is named as 'Charpy seed'. The medlar contains a plurality of amino acids and special nutrient components such as betaine, zeaxanthin, baccatin and the like, so that the medlar has very good health care effect.
Astragalus root, radix astragali is sweet in nature and taste, and is slightly warm. Meridian tropism: it enters lung, spleen, liver and kidney meridians. It is mainly indicated for chronic weakness, low speech and weak pulse because of deficiency.
The angelica has the main function of enriching the blood; promoting blood circulation; regulating menstruation and relieving pain; moistening dryness and smoothing intestine. The main symptoms are blood deficiency; menoxenia; amenorrhea; dysmenorrhea; the accumulation of symptoms; (ii) metrorrhagia and metrostaxis; abdominal pain due to deficiency-cold; flaccidity and paralysis; numbness of the skin; intestinal dryness and difficult defecation; severe dysentery with diarrhea; carbuncle, cellulitis, sore and ulcer; injury from falling.
The stem, leaf, flower, fruit and root of kudzu vine root can be used as medicine. The compendium of materia Medica is recorded as follows: ' Kudzuvine, sweet in nature, pungent, mild and nontoxic, is mainly used for treating: diabetes, fever, vomiting, various maladies, yin qi generation and toxicity elimination.
The epimedium herb is used for medicine. It can be used for treating sexual impotence, premature ejaculation, soreness of waist, skelalgia, numbness of limbs, hemiplegia, neurasthenia, amnesia, tinnitus, and blurred vision.
The maca is rich in high-unit nutrients and has the functions of nourishing and strengthening the body. The alkaloid components have antibacterial, antiviral, hemagglutination resisting, analgesic, antiinflammatory, antitumor and cardiovascular disease resisting effects, and can be used for treating immunologic hypofunction, climacteric syndrome, hysteromyoma, hyperplasia of mammary glands, chronic cardiovascular disease and cerebrovascular disease. With the continuous development of science, various factors such as serious environmental pollution, fast pace of life, overdrawing energy, high working pressure, bad living habits, gradual reduction of physical exercises and the like enable people in sub-health state in modern society to generally exist. The maca has comprehensive and balanced nutritional ingredients and unique active substances, and can effectively strengthen the immune system and improve the sub-health state.
Rhizoma polygonati is a traditional Chinese medicine for tonifying middle-jiao and qi, is taken for a long time to lose weight and prolong life without hunger, belongs to a medicine and food dual-purpose traditional Chinese medicine, and is safe to take. Some people say that the sealwort is the essence of loess; the book of republic of Pupuzzles says: xiren is named because it can obtain the qi of Kun soil and gain the essence of Tian Di.
As recorded in the book 'Benjing' of Chinese herbal medicine, the red dates have sweet and warm taste and warm property, enter spleen and stomach meridians, and have the functions of tonifying middle-jiao and Qi, nourishing blood and tranquilization and relieving drug properties; modern pharmacology finds that the red dates contain rich nutritional ingredients such as proteins, saccharides, organic acids, vitamin A, vitamin C, various trace calcium, amino acids and the like.
Chinese yam is sweet and neutral. Strengthen spleen and stomach, benefit lung and kidney, tonify deficiency and save. Treating anorexia, loose stool, asthenia, cough and asthma, frequent micturition, leukorrhagia, and diabetes; it can be used for treating spleen deficiency, anorexia, diarrhea, and loose stool.
Licorice root is indicated for heart-qi deficiency, palpitation, intermittent pulse, spleen-stomach qi deficiency, lassitude and hypodynamia. The former is usually combined with Gui Zhi, such as Gui Zhi gan Cao Tang and gan Cao Zhi Tang. The latter is often combined with Dang Shen and Bai Zhu, such as Sijun Zi Tang and Lian Zhong Wan.
The technical solution of the present invention is further described with reference to the following specific examples.
Example 1
Case one:
when the male is in 56 years old and language expression disorder and hypokinesia appear before one month, the family members cooperate to carry out hospital admission examination, the initial symptoms of the senile dementia are already obtained in the initial diagnosis, and the senile dementia is confirmed. After the medicine is taken for one month, the brain is clear, the thinking is clear, the speech expression is fluent, the physical symptoms at the early stage of the disease gradually disappear, and the curative effect is obvious.
Case two:
zhao, 89 years old, has suffered from senile dementia for more than three years, and the medicine is taken for nearly three years. However, memory is still progressively reduced, and life cannot be self-managed. After taking the medicine of the application for two months, the person gradually becomes aware of the medicine and can judge daily matters; after the medicine is continuously taken for one year, the patient has stable emotion, the times of anger, irritability and crying are obviously reduced, and the difficulty of caring the patient by family members is obviously reduced.
Example 2
Respectively removing impurities from Ginseng radix, fructus Lycii, radix astragali, radix Angelicae sinensis, radix Puerariae, herba Epimedii, maca, rhizoma Polygonati, fructus Jujubae, rhizoma Dioscoreae, and Glycyrrhrizae radix, cleaning, and air drying; mixing the above materials, and decocting to obtain decoction; concentrating to obtain the Chinese herbal medicine composition for treating senile dementia.
Example 3
Respectively removing impurities from Ginseng radix, fructus Lycii, radix astragali, radix Angelicae sinensis, radix Puerariae, herba Epimedii, maca, rhizoma Polygonati, fructus Jujubae, rhizoma Dioscoreae, and Glycyrrhrizae radix, cleaning, and air drying; respectively placing the processed radix astragali, radix Angelicae sinensis and radix Puerariae in a pulverizer, and performing ultramicro pulverization to obtain radix astragali powder, radix Angelicae sinensis powder and radix Puerariae powder; putting the processed red dates into a pot for frying, and stopping frying when the fragrance of the red dates is given out and the skins of the red dates begin to fall off in a granular manner; removing kernels of the fried red dates, and cutting pulp of the red dates into red date strips for later use; mixing the treated fructus Lycii, Glycyrrhrizae radix, and semen Ziziphi Spinosae prepared in the fourth step, placing in a decocting pan, adding water to submerge the materials, soaking for 6 hr, decocting, and filtering; adding the red date strips prepared in the step four into filter residues obtained by filtering, adding water, continuously decocting, keeping the temperature at 90-100 ℃, continuously heating for 2-3 hours, filtering decoction, and combining filtrates obtained in two times; carrying out reduced pressure concentration on the obtained filtrate to obtain a mixed concentrated solution; peeling the processed yam, cutting yam pulp into 1cm by 1cm yam dices, placing the yam dices in a dryer for drying until the water content is lower than 10%, and taking out; grinding the dried Chinese yam dices, and crushing to obtain Chinese yam fine powder; respectively using the processed epimedium, ginseng, maca and sealwort to prepare an epimedium extract, a ginseng extract, a maca extract and a sealwort extract; mixing radix astragali powder, radix Angelicae sinensis powder, and radix Puerariae powder, concentrating, and mixing herba Epimedii extract, Ginseng radix extract, Lepidium Meyenii Walp extract, and rhizoma Polygonati extract to obtain mixture; placing the mixture in a mould, and placing the mould in a drying box for drying; taking down the mold to obtain a sheet preparation, and carrying out aseptic packaging to obtain the Chinese herbal medicine composition for treating senile dementia.
Example 4
The efficacy of the herbal compositions for treating senile dementia prepared in examples 2 and 3 was measured, mainly the contents of ginseng extract, maca extract and impurities in the drugs, and the results were as follows:
measurement items | Content of Ginseng radix extract (μ g/g) | Maca extract (mu g/g) | Impurities in the medicine (mg/g) |
Example 2 | 0.31 | 0.42 | 12 |
Example 3 | 0.48 | 1.70 | 9 |
The above description is only for the purpose of illustrating the preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, and any modification, equivalent replacement, and improvement made by those skilled in the art within the technical scope of the present invention disclosed herein, which is within the spirit and principle of the present invention, should be covered by the present invention.
Claims (10)
1. The preparation method of the Chinese herbal medicine composition for treating the senile dementia is characterized by comprising the following steps of:
step one, respectively removing impurities from ginseng, medlar, astragalus mongholicus, angelica sinensis, radix puerariae, herba epimedii, maca, rhizoma polygonati, red dates, Chinese yam and liquorice, cleaning and airing;
step two, respectively placing the astragalus, the angelica and the radix puerariae processed in the step one into a grinder for superfine grinding to respectively obtain astragalus powder, angelica powder and radix puerariae powder;
step three, putting the red dates processed in the step one into a pot for frying, and stopping frying when the fragrance of the red dates is fried and the skins of the red dates begin to fall off in a granular manner; removing kernels of the fried red dates, and cutting pulp of the red dates into red date strips for later use;
step four, mixing the wolfberry fruits, the liquorice roots and the jujube kernels prepared in the step three after being processed in the step one, putting the mixture into a frying pan, adding water to immerse the medicinal materials for 6-8 hours, and then decocting and filtering the mixture;
step five, adding the red date strips prepared in the step three into the filter residue obtained by filtering in the step four, adding water, continuously decocting, keeping the temperature at 90-100 ℃, continuously heating for 2-3 hours, filtering decoction, and combining the two filtrates; carrying out reduced pressure concentration on the obtained filtrate to obtain a mixed concentrated solution;
sixthly, peeling the Chinese yam processed in the step one, cutting the Chinese yam pulp into Chinese yam dices with the thickness of 1cm by 1cm, placing the Chinese yam dices into a dryer for drying until the water content of the Chinese yam dices is lower than 10%, and taking out the Chinese yam dices; grinding the dried Chinese yam dices, and crushing to obtain Chinese yam fine powder;
step seven, rolling the whole herb of the epimedium herb to obtain epimedium herb slurry with coexisting solid and liquid; adding 70% ethanol with the mass 8-10 times of that of the epimedium herb slurry into an extraction device, heating and extracting for 4-6 hours, and concentrating until the relative density is 1.10-1.20 to obtain thick paste A;
step eight, diluting the thick paste A with water, then loading the diluted thick paste A to a macroporous adsorption resin column, eluting with distilled water and 85 v/v% ethanol in sequence, collecting 85 v/v% ethanol eluent, recovering ethanol, and concentrating until the relative density is 1.10-1.20 to obtain thick paste B;
step nine, after extraction is finished, diluting the thick paste B with water, and then performing DAC chromatographic separation and elution; collecting eluent of 28-40 min, and decompressing and concentrating the eluent to 1/3 of the volume of the initial mixed liquid; spray drying to obtain herba Epimedii extract granule;
step ten, cutting the ginseng into thick pieces with the thickness of 0.2-0.3 cm, and placing the thick pieces in an extraction device; adding ethanol into the leaching device for reflux leaching; filtering the leaching liquor after leaching, and filtering out solid impurities to obtain clear liquid;
step eleven, slowly heating the obtained clear liquid at 40-60 ℃, and stopping heating after the ethanol is completely volatilized to obtain a ginseng extracting solution; continuously heating the ginseng extract at 40-50 ℃, and evaporating water to dryness; fully drying the ginseng extract and filter residue obtained by filtering, grinding, and sieving by a 100-mesh sieve to obtain a ginseng extract;
step twelve, respectively preparing a maca extract and a polygonatum extract from the maca and the polygonatum processed in the step one; mixing the prepared astragalus powder, angelica powder, kudzu root powder, mixed concentrated solution, epimedium extract, ginseng extract, maca extract and sealwort extract to obtain a mixture;
step thirteen, placing the mixture prepared in the step twelve into a mould, and placing the mould into a drying box for drying; taking down the mould to obtain a sheet preparation, and carrying out aseptic packaging to obtain the Chinese herbal medicine composition for treating senile dementia.
2. The method for preparing a herbal composition for the treatment of Alzheimer's disease as claimed in claim 1, wherein in step two, the particle size of the radix astragali powder, radix Angelicae sinensis powder, and radix Puerariae powder is less than 20 μm.
3. The method of claim 1, wherein in step five, the decoction is carried out under the following conditions: heating at 80-85 ℃ for 10-20 min, heating at 150-160 ℃ for 30-35 min after water is boiled, and then cooling to 60 ℃ for heating for 2-4 h.
4. The method for preparing a herbal composition for the treatment of senile dementia as claimed in claim 1, wherein in the ninth step, said concentration under reduced pressure is specifically: setting the pressure to be 2.0-2.5 kPa, the temperature of the filtrate to be 70-75 ℃, and the concentration time to be 20-30 min, and carrying out reduced pressure concentration on the filtrate.
5. The method for preparing a herbal composition for the treatment of senile dementia as claimed in claim 1, wherein in the ninth step, the DAC column size is 250 x 600mm, the filler is C18, and the particle size is 10-15 μm.
6. The method for preparing a herbal composition for the treatment of senile dementia as claimed in claim 1, wherein in the ninth step, the flow rate of elution is 250-300 mL/min; the detection wavelength is 270-300 nm; the column pressure is 10-15 Mpa.
7. The method of preparing a herbal composition for the treatment of senile dementia according to claim 1, wherein the maca extract is prepared by:
(I) airing the treated maca until the maca is dry, wherein the water content is not more than 5%; crushing the aired maca into mud residue in a crusher;
(II) soaking the sludge-shaped maca in 70% ethanol for 3-4 days to obtain a maca mixture;
(III) putting the soaked maca mixture into a spin dryer for spin-drying separation, and canning the effluent liquid;
(IV) standing the liquid in the tank for 3-5 h, and filtering out the supernatant to obtain the maca extract.
8. The method for preparing a herbal composition for the treatment of senile dementia as set forth in claim 1, wherein in the twelfth step, the polygonatum sibiricum extract is prepared by:
(1) putting the treated rhizoma polygonati into a leaching device, adding 70% ethanol for reflux leaching to obtain a leaching solution;
(2) removing solid impurities in the leaching liquor to obtain clear liquid;
(3) slowly heating the obtained clear liquid at the temperature of 40-60 ℃;
(4) stopping heating after the ethanol is completely volatilized, and cooling to obtain the rhizoma polygonati extract.
9. The method for preparing a herbal composition for treating senile dementia according to claim 1, wherein in the thirteen steps, the step of drying in a drying oven comprises: and (3) putting the mould with the mixture into a drying box, setting the drying temperature to be 30-40 ℃ and the drying time to be 24-28 h.
10. The Chinese herbal medicine composition for treating senile dementia, which is prepared by the preparation method of the Chinese herbal medicine composition for treating senile dementia according to any one of claims 1 to 9, is characterized by comprising, by mass, 4-7 parts of ginseng, 6-8 parts of wolfberry fruit, 3-4 parts of astragalus membranaceus, 4-5 parts of angelica sinensis, 6-8 parts of radix puerariae, 1-3 parts of herba epimedii, 4-6 parts of maca, 2-3 parts of rhizoma polygonati, 4-5 parts of red dates, 2-5 parts of Chinese yam and 1-2 parts of liquorice.
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