CN104510784A - Insomnia treatment traditional Chinese medicine composition - Google Patents
Insomnia treatment traditional Chinese medicine composition Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
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Abstract
The invention belongs to the technical field of traditional Chinese medicines, and discloses an insomnia treatment traditional Chinese medicine composition mainly composed of the following Chinese herbal medicines: nacre mother of pearl, tuber fleeceflower stem, ligustrum lucidum, yerbadetajo herb, pseudostellaria root, prepared fleece flower root and frankincense. The insomnia treatment traditional Chinese medicine composition is reasonable in compatibility, streamline in administration, very good in curative effect on insomnia caused by different treatment traditional Chinese syndrome types and different diseases, may not produce drug resistance due to continuous administration, and has the characteristics of rapid effects, remarkable curative effects and radical treatment.
Description
Technical field
The invention belongs to technical field of Chinese medicines, relate to Chinese medicine composition of a kind of Cure for insomnia and preparation method thereof.
Background technology
Insomnia, refers to often can not obtain normal sleep.The lighter's difficulty falling asleep, or sleep and disintoxicated, sometimes sleeping and sometimes waking, wake up after can not fall asleep again; Severe one is lain awake all night, and is clinical commonly encountered diseases, frequently-occurring disease.Chinese medicine is referred to as " being insomnia ", " must not crouch ", " insomnia ", " unable to close the eyes " etc.
The Chinese medicine of existing Cure for insomnia mainly contains: mixture of calming the nerves, ANSHEN BUXIN WAN, Anshen Bunao sheet, tranquilizing and blood nourishing ball etc., and because curative effect is remarkable, the course for the treatment of is long, has now used less.
The patient of current insomnia adopts medical treatment mostly, and it is rapid-action, successful, and for extensive patients accepts, right western medicine insomnia, side effect is large, and drug dependence is strong, easily produces tolerance.
Summary of the invention
In order to make up the deficiencies in the prior art, the Chinese medicine composition of the Cure for insomnia that the present invention is not easily recurred after supplying a kind of rapid-action, short treating period, healing.
The technical solution used in the present invention is as follows:
A Chinese medicine composition for Cure for insomnia, is prepared from primarily of Chinese crude drug:
Concha Margaritifera, Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum.
Preferably, the present invention controls the Chinese medicine composition of insomnia, is prepared from by the Chinese crude drug of following weight portion:
Concha Margaritifera 20-40, Caulis Polygoni Multiflori 20-40, Fructus Ligustri Lucidi 10-20, Herba Ecliptae 10-20, Radix Pseudostellariae 5-10, Radix Polygoni Multiflori Preparata 5-10, Olibanum 2-10.
As optimal technical scheme of the present invention, the Chinese medicine composition of Cure for insomnia of the present invention, is prepared from by the Chinese crude drug of following weight portion: Concha Margaritifera 30, Caulis Polygoni Multiflori 28, Fructus Ligustri Lucidi 15, Herba Ecliptae 20, Radix Pseudostellariae 6, Radix Polygoni Multiflori Preparata 6, Olibanum 6.
The Chinese medicine composition of aforesaid Cure for insomnia, can be prepared into any one oral formulations clinically.
Aforesaid oral formulations is preferably: powder, tablet, granule, capsule, microcapsule, pill, drop pill, oral liquid, soft capsule, syrup, dispersant, thin membrane coated tablet or effervescent tablet.
The preparation method of aforesaid oral formulations comprises the following steps:
Steps A: take Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae three taste medical material by above-mentioned formula, be ground into coarse powder, extract 2 times with 8-10 times amount 60-75% alcohol heating reflux, each 1-2 hour, obtains extracting solution, filters, and concentrating under reduced pressure obtains clear paste after reclaiming ethanol;
Step B: by steps A gained clear paste, under the condition of 50-70 DEG C, decompression drying, gets dry extract, cross 80-120 mesh sieve after pulverizing, get dry extract powder;
Step C: take Concha Margaritifera, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum four Chinese medicine material by above-mentioned formula, dry, pulverized 80-120 mesh sieve, obtain powder;
Step D: by step B gained dried cream powder and step C gained powder mix homogeneously, add conventional adjuvant and be prepared into oral formulations.
In steps A, Extracting temperature is 80 DEG C-90 DEG C.
In step B, described clear paste, the relative density recorded 20 DEG C time is 1.2.
Fang Zhong:
Concha Margaritifera: nature and flavor is salty, cold.Gui Jing, returns liver, heart channel.Function cures mainly, suppressing the hyperactive liver and subsiding YANG, arresting convulsion improving eyesight.Dizzy for having a headache, irritated insomnia, liver-heat conjunctival congestion, deficiency of the liver blurred vision.
Fructus Ligustri Lucidi: nature and flavor are sweet; Bitter; Cool in nature.Return liver; Kidney channel.Function cures mainly, liver and kidney tonifying; Clearind deficient heat; Improving eyesight.Main Light-headedness; Soreness of the waist and knees; Seminal emission; Tinnitus; Early whitening of beard and hair, osteopyrexia and fever.
Caulis Polygoni Multiflori: nature and flavor are sweet; Micro-hardship; Property is put down.GUIXIN; Liver Channel.Function cures mainly, tranquilizing by nourishing the heart; Dispel the wind; Dredging collateral.Main insomnia; Dreaminess; Blood deficiency general pain; Numbness of the skin; Rheumatic arthralgia; Rubella pruritus.
Herba Ecliptae: nature and flavor are sweet, sour, cold.Return kidney, Liver Channel.Function cures mainly, nourishing the liver and kidney, cooling blood for hemostasis.For odontoseisis, early whitening of beard and hair, vertigo and tinnitus, soreness of the waist and knees, YinXuXueRe, haematemesis, epistaxis, hematuria, dysentery, metrostaxis, traumatic hemorrhage.
Radix Pseudostellariae: sweet, the micro-hardship of nature and flavor is flat.Return spleen, lung meridian.Function cures mainly, replenishing QI to invigorate the spleen, promoting the production of body fluid for nourishing the lung.Tired for insufficiency of the spleen body, inappetence, weak after being ill, deficiency of both vital energy and Yin, spontaneous perspiration is thirsty, dryness of the lung dry cough.
Radix Polygoni Multiflori Preparata: nature and flavor are bitter, sweet, puckery, temperature.Return liver, the heart, kidney channel.Function cures mainly, removing toxic substances, eliminating carbuncle, loosening bowel to relieve constipation.For scrofula carbuncle sore, rubella pruritus, dryness of the intestine constipation; Hyperlipidemia.
Olibanum: nature and flavor are pungent; Bitter; Tepor, GUIXIN; Liver; Spleen channel.Function cures mainly, blood-activating and qi-promoting; Inducing menstruation to relieve menalgia; Detumescence and promoting granulation.Main trusted subordinate's pain; Rheumatic arthralgia; Amenorrhea dysmenorrhea; Traumatic injury stasis of blood pain; Swollen ulcer drug; Intestinal carbuncle; The sore being festered and unhealed
Concha Margaritifera in present composition side, Fructus Ligustri Lucidi are calmed the nerves arresting convulsion, nourishing the liver and kidney; Be aided with Caulis Polygoni Multiflori, Herba Ecliptae clearing away heart-fire for tranquillization, dispelling wind and removing obstruction in the collateral, help with Radix Pseudostellariae, Radix Polygoni Multiflori Preparata YIN nourishing and QI supplementing, Olibanum is invigorated blood circulation, and runs all medicines.All medicines with the use of can tranquilizing by nourishing the heart, nourishing the liver and kidney.Beneficial effect of the present invention: the present invention is according to Basic Theories of Chinese Medicine, verify through long-term clinical application, compatibility of the present invention is reasonable, medication is simplified, all there is good curative effect to the insomnia caused by different TCM Syndrome Type and various disease, and do not produce drug resistance because of successive administration, have rapid-action, evident in efficacy, the feature of digging up the roots of curing the disease.
detailed description of the invention:
eXAMPLE l
The Chinese medicine composition of Cure for insomnia of the present invention, is prepared from by the Chinese crude drug of following weight portion: Concha Margaritifera 30, Caulis Polygoni Multiflori 28, Fructus Ligustri Lucidi 15, Herba Ecliptae 20, Radix Pseudostellariae 6, Radix Polygoni Multiflori Preparata 6, Olibanum 6.
Preparation method is as follows:
Steps A: take Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae three taste medical material by above-mentioned formula, be ground into coarse powder, extract 2 times with 9 times amount 70% alcohol heating reflux, each 1.5 hours, obtain extracting solution, filter, concentrating under reduced pressure obtains clear paste, described clear paste after reclaiming ethanol, the relative density recorded 20 DEG C time is 1.2, and described reflux, extract, temperature is 80 DEG C;
Step B: by steps A gained clear paste, under the condition of 60 DEG C, decompression drying, gets dry extract, cross 80 mesh sieves after pulverizing, get dry extract powder;
Step C: take Concha Margaritifera, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum four Chinese medicine material by above-mentioned formula, dry, pulverized 80 mesh sieves, obtain powder;
Step D: by step B gained dried cream powder and step C gained powder mix homogeneously, add conventional adjuvant and be prepared into capsule, every containing crude drug 0.6g.
embodiment 2
The Chinese medicine composition of Cure for insomnia of the present invention, is prepared from by the Chinese crude drug of following weight portion: Concha Margaritifera 30, Caulis Polygoni Multiflori 24, Fructus Ligustri Lucidi 20, Herba Ecliptae 10, Radix Pseudostellariae 10, Radix Polygoni Multiflori Preparata 10, Olibanum 10.
Preparation method is as follows:
Steps A: take Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae three taste medical material by above-mentioned formula, be ground into coarse powder, extract 2 times with 10 times amount 75% alcohol heating reflux, each 1.5 hours, obtain extracting solution, filter, concentrating under reduced pressure obtains clear paste, described clear paste after reclaiming ethanol, the relative density recorded 20 DEG C time is 1.2, and described reflux, extract, temperature is 85 DEG C;
Step B: by steps A gained clear paste, under the condition of 50 DEG C, decompression drying, gets dry extract, cross 80 mesh sieves after pulverizing, get dry extract powder;
Step C: take Concha Margaritifera, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum four Chinese medicine material by above-mentioned formula, dry, pulverized 80 mesh sieves, obtain powder;
Step D: by step B gained dried cream powder and step C gained powder mix homogeneously, add conventional adjuvant and be prepared into tablet, every sheet is containing crude drug 0.4g.
embodiment 3
The Chinese medicine composition of Cure for insomnia of the present invention, is prepared from by the Chinese crude drug of following weight portion: Concha Margaritifera 40, Caulis Polygoni Multiflori 40, Fructus Ligustri Lucidi 20, Herba Ecliptae 18, Radix Pseudostellariae 10, Radix Polygoni Multiflori Preparata 6, Olibanum 6.
Preparation method is as follows:
Steps A: take Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae three taste medical material by above-mentioned formula, be ground into coarse powder, extract 2 times with 8 times amount 70% alcohol heating reflux, each 1.5 hours, obtain extracting solution, filter, concentrating under reduced pressure obtains clear paste, described clear paste after reclaiming ethanol, the relative density recorded 20 DEG C time is 1.2, and described reflux, extract, temperature is 90 DEG C;
Step B: by steps A gained clear paste, under the condition of 70 DEG C, decompression drying, gets dry extract, cross 80 mesh sieves after pulverizing, get dry extract powder;
Step C: take Concha Margaritifera, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum four Chinese medicine material by above-mentioned formula, dry, pulverized 80 mesh sieves, obtain powder;
Step D: by step B gained dried cream powder and step C gained powder mix homogeneously, add conventional adjuvant and be prepared into granule agent, every bag containing crude drug 2.4g.
embodiment 4
The Chinese medicine composition of Cure for insomnia of the present invention, is prepared from by the Chinese crude drug of following weight portion: Concha Margaritifera 20, Caulis Polygoni Multiflori 20, Fructus Ligustri Lucidi 10, Herba Ecliptae 10, Radix Pseudostellariae 5, Radix Polygoni Multiflori Preparata 6, Olibanum 6.
Preparation method is as follows:
Steps A: take Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae three taste medical material by above-mentioned formula, be ground into coarse powder, extract 2 times with 9 times amount 75% alcohol heating reflux, each 1.5 hours, obtain extracting solution, filter, concentrating under reduced pressure obtains clear paste, described clear paste after reclaiming ethanol, the relative density recorded 20 DEG C time is 1.2, and described reflux, extract, temperature is 80 DEG C;
Step B: by steps A gained clear paste, under the condition of 65 DEG C, decompression drying, gets dry extract, cross 80 mesh sieves after pulverizing, get dry extract powder;
Step C: take Concha Margaritifera, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum four Chinese medicine material by above-mentioned formula, dry, pulverized 80 mesh sieves, obtain powder;
Step D: by step B gained dried cream powder and step C gained powder mix homogeneously, add conventional adjuvant and be prepared into pill, every containing crude drug 2g.
beneficial effect of the present invention is set forth in the 98 routine clinical summary reports that logical inventor place out-patient department Neurology Department adopts Drug therapy of the present invention to have a sleepless night below further.
general clinical data:
The frequent insomnia and dreamful sleep of 98 routine patient selected, the length of one's sleep is short, and average length of one's sleep, 2-3 hour, had difficulty in going to sleep after waking up, age 21-63 year, average 41 years old.The course of disease with 30 days-2 years for object of study.
tcm diagnosis standard:
" Chinese medical disease Standardization of diagnosis and curative effect " middle deficiency syndrome that diagnostic criteria is formulated with reference to State Administration of Traditional Chinese Medicine, the diagnostic criteria of excess syndrome institute induced insomnia are drafted.All diseases see the lighter's difficulty of falling asleep or sleep but easy to wake, and be insomnia after waking up, severe one is lain awake all night, and with headache and dizziness, palpitation and amnesia, the diseases such as dreaminess are main clinical manifestation person.
medicine and Therapeutic Method:
All treatment patients cut out any medicine with soporific function in first 3 days, give capsule prepared by optimizing prescriptions of the present invention, every day 3 times, each 6; Within 7 days, be a course for the treatment of, took for 4 courses for the treatment of continuously
curative effect determinate standard:
Diagnostic criteria is by the standard envisages of " guideline of clinical investigations of new Chinese medicine Cure for insomnia " in " new Chinese medicine guideline of clinical investigations ".
Recovery from illness: fall asleep smoothly, recover the length of one's sleep normal, or the length of one's sleep is at more than 6hr, sleeps deep, its clinical symptoms disappears substantially.
Effective: sleep is clearly better, and the length of one's sleep increases more than 3hr, Depth of sleep increases, and clinical symptoms makes moderate progress.
Effective: symptom alleviates, the length of one's sleep, comparatively front increase was less than 3hr.
Invalid: after treatment, insomnia is not improved or instead adds severe one, and clinical symptoms is also not improved.
therapeutic outcome:
In 98 routine patients, clinical recovery is 60 examples (61.2%), and effective is 22 examples (22.4%), effective 14 examples (14.3%), invalid 2(2.0%), total effective rate reaches 98.0%.All healing follow-up of patients have no recurrence half a year.There are no any toxicity or gastrointestinal upset in therapeutic process.
model case
1. Wu, female, 29 years old, long-term operating pressure and daily schedule irregularly caused serious insomnia, can not sleep soundly after sleep, the length of one's sleep of every day, every day had dizzy spells generally at 3 hours, once used a variety of western medicine, form drug dependence, and using dosage was increasing.After giving medicine of the present invention 4 course of therapy, sleep quality significantly improves, and is increased to 7 hours during sleep, full of vitality.Follow up a case by regular visits to six months, without recurrence.
2. Zhang, man, 40 years old, half a year, cause was working principle, upset, and caused insomnia, and average 2-3 hour existing length of one's sleep every day, poliosis increases, and temper is deteriorated, and often has a headache, forgets things.After giving medicine of the present invention 4 course of therapy, sleep quality significantly improves, and is increased to 6 hours during sleep, full of vitality, and irritated emotion is eased.Follow up a case by regular visits to six months, without recurrence.
3. Wang, man, 38 years old, suffer from insomnia 1 year, cardinal symptom was difficulty falling asleep, and the length of one's sleep is short, and repeatedly, timidity and palpitation, easily shies when anything crops up in bad dream; After giving medicine of the present invention 4 course of therapy, sleep quality significantly improves, and is increased to more than 6 hours, clinical symptom disappearance during sleep.Follow up a case by regular visits to six months, without recurrence.
4. Lee, female, 32 years old, suffer from insomnia 1 year, cardinal symptom was difficulty falling asleep, dreaminess, Yi Xing, palpitation and amnesia, had a dizzy spell, its dim complexion, lethargy, depressed emotions.After giving medicine of the present invention 4 course of therapy, sleep quality significantly improves, and is increased to more than 6 hours, clinical symptom disappearance during sleep.Follow up a case by regular visits to six months, without recurrence.
Claims (8)
1. a Chinese medicine composition for Cure for insomnia, is characterized in that, is prepared from by following Chinese crude drug: Concha Margaritifera, Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum.
2. Chinese medicine composition according to claim 1, is characterized in that, be prepared from by the Chinese crude drug of following weight portion:
Concha Margaritifera 20-40, Caulis Polygoni Multiflori 20-40, Fructus Ligustri Lucidi 10-20, Herba Ecliptae 10-20, Radix Pseudostellariae 5-10, Radix Polygoni Multiflori Preparata 5-10, Olibanum 2-10.
3. Chinese medicine composition according to claim 1, is characterized in that, be prepared from by the Chinese crude drug of following weight portion: Concha Margaritifera 30, Caulis Polygoni Multiflori 28, Fructus Ligustri Lucidi 15, Herba Ecliptae 20, Radix Pseudostellariae 6, Radix Polygoni Multiflori Preparata 6, Olibanum 6.
4. Chinese medicine composition according to claim 1, is characterized in that, described Chinese medicine composition, can be prepared into any one oral formulations clinically.
5. Chinese medicine composition according to claim 4, it is characterized in that, described oral formulations is: powder, tablet, granule, capsule, microcapsule, pill, drop pill, oral liquid, soft capsule, syrup, dispersant, thin membrane coated tablet or effervescent tablet.
6. Chinese medicine composition according to claim 4, it is characterized in that, the preparation method of described oral formulations comprises the following steps:
Steps A: take Caulis Polygoni Multiflori, Fructus Ligustri Lucidi, Herba Ecliptae three taste medical material by above-mentioned formula, be ground into coarse powder, extract 2 times with 8-10 times amount 60-75% alcohol heating reflux, each 1-2 hour, obtains extracting solution, filters, and concentrating under reduced pressure obtains clear paste after reclaiming ethanol;
Step B: by steps A gained clear paste, under the condition of 50-70 DEG C, decompression drying, gets dry extract, cross 80-120 mesh sieve after pulverizing, get dry extract powder;
Step C: take Concha Margaritifera, Radix Pseudostellariae, Radix Polygoni Multiflori Preparata, Olibanum four Chinese medicine material by above-mentioned formula, dry, pulverized 80-120 mesh sieve, obtain powder;
Step D: by step B gained dried cream powder and step C gained powder mix homogeneously, add conventional adjuvant and be prepared into oral formulations.
7. Chinese medicine composition according to claim 6, it is characterized in that, in the preparation method steps A of described oral formulations, Extracting temperature is 80 DEG C-90 DEG C.
8. Chinese medicine composition according to claim 6, it is characterized in that, in the preparation method step B of described oral formulations, described clear paste, the relative density recorded 20 DEG C time is 1.2.
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| CN112316091A (en) * | 2020-10-20 | 2021-02-05 | 河北省中医院 | A kind of traditional Chinese medicine composition for treating insomnia and its foot bath solid preparation |
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| CN103721027A (en) * | 2013-12-26 | 2014-04-16 | 青岛永通电梯工程有限公司 | Traditional Chinese medicine composition helpful for sleep improvement |
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| CN103721027A (en) * | 2013-12-26 | 2014-04-16 | 青岛永通电梯工程有限公司 | Traditional Chinese medicine composition helpful for sleep improvement |
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| CN112316091A (en) * | 2020-10-20 | 2021-02-05 | 河北省中医院 | A kind of traditional Chinese medicine composition for treating insomnia and its foot bath solid preparation |
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Application publication date: 20150415 |