CN103933485A - Traditional Chinese medicine composition for repelling dog odour and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition for repelling dog odour and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for repelling dog odour and a preparation method thereof. The traditional Chinese medicine composition disclosed by the invention comprises the following raw medicinal materials: poria cocos, exocarpium citri rubrum, emblic leafflower fruit, felwort, sticky rice, kamuning, curcuma zedoary, radix angelicae, sandalwood, mint, borneol, juice of Japanese raisin tree, liquorice, red-knees herb and usnea longissima. By utilizing traditional Chinese medicine theories in China, the traditional Chinese medicine composition disclosed by the invention is mainly used for dehumidifying, dredging orifices, removing dirt and eliminating odour and has the advantages of being good in effect, high in safety, free from toxic and side effects and low in cost for repelling dog odour.
Description
Technical field
The present invention relates to a kind of medicine for animal taking plant or animal as source, particularly a kind of for driving Chinese medicine composition that dog is smelly and preparation method thereof.
Background technology
Pet dog has become a requisite part in people's life at present, but pet dog itself just has specific body odour, if have parasite as flea, acarid etc., will cause dermatosis, cause body odor, some parasites or dirt are ensconced in pet hair and are difficult to clean, and house pet fond of play always can make very dirty health, and stink is more serious.Although there are house pet perfume or deodorizer to cover at present, or the medicine for the treatment of pet skin disease, great majority formula is comprehensive formula, quality is unstable, in use lacks scientific guidance, has very large blindness, DeGrain, can not meet the requirement of the clean and deodorization of pet owner.The compatibility of Chinese herbal medicine is rigorous, and treatment dog is antibacterial smelly time, Promote immunity power, prevent disease.
Summary of the invention
Technical problem to be solved by this invention is, provides a kind of for driving Chinese medicine composition that dog is smelly and preparation method thereof, and this Chinese medicine composition is sensible to dehumidify, keep away dirty deodorization as main, and for driving, dog is smelly has an advantage effective, safe, that have no side effect.
In order to solve the problems of the technologies described above, the invention provides a kind of for driving the Chinese medicine composition that dog is smelly, wherein, described Chinese medicine composition comprises following raw medicinal material: Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae, Lignum Santali Albi, Herba Menthae, Borneolum Syntheticum, Sucus Hoveniae, Radix Glycyrrhizae, Herba polygoni hydropiperis and ceiling grass.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Poria 10-25 weight portion, Exocarpium Citri Rubrum 10-20 weight portion, Fructus Phyllanthi 10-20 weight portion, Radix Gentianae 10-20 weight portion, Oryza glutinosa 10-20 weight portion, Folium Et Cacumen Murrayae 15-25 weight portion, Rhizoma Curcumae 10-20 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Lignum Santali Albi 15-25 weight portion, Herba Menthae 10-20 weight portion, Borneolum Syntheticum 10-15 weight portion, Sucus Hoveniae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Herba polygoni hydropiperis 10-26 weight portion and ceiling grass 10-18 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Poria 14-22 weight portion, Exocarpium Citri Rubrum 13-18 weight portion, Fructus Phyllanthi 10-15 weight portion, Radix Gentianae 15-20 weight portion, Oryza glutinosa 15-20 weight portion, Folium Et Cacumen Murrayae 17-22 weight portion, Rhizoma Curcumae 13-17 weight portion, Radix Angelicae Dahuricae 13-17 weight portion, Lignum Santali Albi 18-22 weight portion, Herba Menthae 14-18 weight portion, Borneolum Syntheticum 12-15 weight portion, Sucus Hoveniae 12-18 weight portion, Radix Glycyrrhizae 13-20 weight portion, Herba polygoni hydropiperis 15-23 weight portion and ceiling grass 12-15 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can be preferably again: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions and ceiling grass 13 weight portions.
Described Chinese medicine composition also comprises: Flos Lonicerae, Herba Meliloti Suaveolentis, Herba Ocimi (Herba Ocimi Pilosi) and Radix Puerariae.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Poria 10-25 weight portion, Exocarpium Citri Rubrum 10-20 weight portion, Fructus Phyllanthi 10-20 weight portion, Radix Gentianae 10-20 weight portion, Oryza glutinosa 10-20 weight portion, Folium Et Cacumen Murrayae 15-25 weight portion, Rhizoma Curcumae 10-20 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Lignum Santali Albi 15-25 weight portion, Herba Menthae 10-20 weight portion, Borneolum Syntheticum 10-15 weight portion, Sucus Hoveniae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Herba polygoni hydropiperis 10-26 weight portion, ceiling grass 10-18 weight portion, Flos Lonicerae 10-20 weight portion, Herba Meliloti Suaveolentis 10-20 weight portion, Herba Ocimi (Herba Ocimi Pilosi) 10-20 weight portion and Radix Puerariae 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions, ceiling grass 13 weight portions, Flos Lonicerae 15 weight portions, Herba Meliloti Suaveolentis 18 weight portions, Herba Ocimi (Herba Ocimi Pilosi) 14 weight portions and Radix Puerariae 16 weight portions.
In order better to realize foregoing invention object, the invention provides that a kind of the dosage form of described Chinese medicine composition is powder for driving the preparation method of the Chinese medicine composition that dog is smelly, described preparation method comprises the following steps:
The first step, Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae and Lignum Santali Albi are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, in proportion by the raw medicinal material except Herba Menthae and Borneolum Syntheticum in surplus stock medical material, mix, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, by Herba Menthae and Borneolum Syntheticum extraction by steam distillation, obtains crystal;
The 5th step, the crystal that the powder that the first step, second step and the 3rd step are obtained and the 4th step obtain mixes, and is screened into subsequently 80～120 object fine powder things, and the fine powder thing of acquisition is dropped in mixing and blending machine and stirred, and obtains described Chinese powder medicine.
The invention has the beneficial effects as follows: Chinese medicine composition of the present invention, utilize the traditional theory of Chinese medical science of China, sensible to dehumidify, keep away dirty deodorization as main, for drive dog smelly have effective, safe, have no side effect, cheap advantage.
Detailed description of the invention
The invention provides a kind of for driving the Chinese medicine composition that dog is smelly, wherein, comprise following raw medicinal material: Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae, Lignum Santali Albi, Herba Menthae, Borneolum Syntheticum, Sucus Hoveniae, Radix Glycyrrhizae, Herba polygoni hydropiperis and ceiling grass; Preferably, Chinese medicine composition also comprises: Flos Lonicerae, Herba Meliloti Suaveolentis, Herba Ocimi (Herba Ocimi Pilosi) and Radix Puerariae.
Wherein, the pharmacology of above-mentioned raw materials medical material is as follows:
Poria: sweet, light, flat.GUIXIN, lung, spleen, kidney channel.Function promoting diuresis to eliminate damp pathogen, spleen invigorating mind calming.For edema oliguria, phlegm retention vertigo and palpitation, insufficiency of the spleen lack of appetite, have loose bowels in loose stool, irritability, palpitation with fear insomnia.Eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, palpitation with fear, forgetful." herbal classic " carries it: " the contrary gas of the main breast side of body, melancholy is angerd frightened heresy and probably throbbed with fear, knot pain under the heart, cold and heat stuffy sensation with restlessness, cough with dyspnea, mouthful burnt dry tongue, diuresis." " not Lu ": " and only quench one's thirst, like to sleep, large abdomen, drenches drop, the disease due to obstruction of QI of middle-JIAO expectorant water, and edema is drenched knot.Open breast internal organs, adjust visceral-qi, cut down kidney heresy, long cloudy, physical strength profiting, during guarantor god keeps." " property of medicine opinion ": " appetizing, preventing or arresting vomiting is contrary, kind tranquilizing mind.Main consumptive lung disease expectorant is stopped up.Control pediatric epilepsy scared, trusted subordinate's distension, married woman's pyretic stranguria.”
Exocarpium Citri Rubrum: pungent, bitter, temperature.Return lung, spleen channel.Function cures mainly: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
Fructus Phyllanthi: be Tibetan's conventional crude drugs.For the dry mature fruit of Euphorbiaceae phyllanthus emblica platymiscium Fructus Phyllanthi Phyllanthus emblica L..Winter to time spring gathers when fruit maturation, removes impurity, dry.Really: clearing away heat and cooling blood, promoting digestion and invigorating the stomach, the cough-relieving of promoting the production of body fluid.For heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia." national Chinese herbal medicine compilation " root: for hypertension, stomachache, enteritis, tuberculous lymphadenitis.Leaf: damp eliminating diuresis.For edema, skin eczema.Used in the present invention is exactly the fruit of Fructus Phyllanthi.Fructus Phyllanthi is the fruit of Euphorbiaceae phyllanthus plant Fructus Phyllanthi (Phyllanthus emblica L), and Fructus Phyllanthi fruit sour in the mouth is micro-puckery, clearing away heat and cooling blood, digestion-promoting spleen-invigorating, promoting the production of body fluid to quench thirst.Cure mainly heat in blood blood stasis, dyspepsia, abdominal distention, cough, laryngalgia, xerostomia and vitamin C deficiency disease.In Tibetan medicine, Fructus Phyllanthi cures mainly Baconic's disease, red bar disease, disorders of blood, hypertension etc.Research in recent years result shows, Fructus Phyllanthi has antiinflammatory, antioxidation, and defying age, the effect such as protects the liver.
Radix Gentianae: hardship, cold.Return liver, gallbladder meridian.Function cures mainly: heat clearing and damp drying, eliminating pathogen in the liver gallbladder fire.For jaundice due to damp-heat, swelling of the vulva pudendal pruritus, leukorrhagia, persistent erection of the penis, eczema pruritus, conjunctival congestion, deafness, hypochondriac pain, bitter taste, convulsion with spasms.
Oryza glutinosa: sweet, temperature.Cure mainly invigorating the spleen and replenishing QI, control the frequent micturition of quenching one's thirst, spontaneous perspiration, just lets out.For insufficiency of the spleen lack of appetite, weak loose stool, woman hysteria.Immunosuppressive action: the ethanol extract of Fructus Jujubae with every days 100 mg to rat oral gavage, show Fructus Jujubae there is same immunosuppressive action with azathioprine, can suppress the generation of antibody to atopic diseases.Fructus Jujubae ethanol extract may have inhibitory action to rat reactive antibody, and non-reacted antibody is not produced to inhibitory action.The two glucoside A of flavone in Fructus Jujubae, pharmacological evaluation proves to have calmness, hypnosis and hypotensive effect, Fructus Jujubae to have the effect that increases cAMP in leukocyte.Fructus Jujubae decoct can reduce the damage of CCl4 to liver.
Folium Et Cacumen Murrayae: pungent, micro-hardship, temperature.Function cures mainly: promoting the circulation of QI to relieve pain, promoting blood circulation to remove blood stasis.For stomachache, rheumatic arthralgia; External treatment toothache, tumbling and swelling, worm venom.
Rhizoma Curcumae: pungent, bitter, temperature.Return liver, spleen channel.Function cures mainly: circulation of qi promoting removing blood stasis, removing food stagnancy pain relieving.For Dan abdominal mass mass in the abdomen, blood stasis amenorrhea, food stagnation distending pain; Early cervical carcinoma.
The Radix Angelicae Dahuricae: warm in nature, acrid in the mouth function cures mainly wind-damp dispelling, the evacuation of pus of invigorating blood circulation, granulation promoting pain relieving.For headache, toothache, nasal sinusitis, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus.Antipyretic effect: the hot animal model of height causing in White Rabbit back with peptone subcutaneous injection, the 1g Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 15g/kg, have obvious refrigeration function.The mouse stomach Radix Angelicae Dahuricae or Radix angelicae dahuricae decoct 8g/kg, obviously reduce the mouse writhing number of times due to lumbar injection 1% acetic acid (0.l/kg), and effect is similar with aminophenazone 8mg/kg, P<0.001.Woolfe-Macdonald method test, the front threshold of pain of administration person in 30 minutes, gavage awards the Radix Angelicae Dahuricae or Radix angelicae dahuricae 8g/kg, and after administration 60 minutes, the Radix Angelicae Dahuricae and the anti-Radix Angelicae Dahuricae obviously improved pain threshold, with relatively P<0.001 and 0.01 of normal saline group." property of medicine opinion ": control the twinge of trusted subordinate's blood, exorcising, main woman's metrorrhagia and vomiting, improving eyesight, arresting lacrimation go out, and treat married woman's drop blood, waist stomachache; Can lose pus.
Lignum Santali Albi: pungent, temperature.Return spleen, stomach, the heart, lung meridian.Function cures mainly: circulation of qi promoting warming middle-JIAO, appetizing pain relieving.For QI stagnated by cold, chest pain, stomachache, stomachache lack of appetite; Coronary heart disease, angina pectoris.
Herba Menthae: be one of Chinese conventional Chinese medicine.It is pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, the dental bed disease such as swell and ache.Place with can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc.All herbal medicine, pungent, cool.Return lung, Liver Channel, there is the wind heat of dispersing, clearing throat, rash removing toxic substances, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to that cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, the disease such as colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.
Borneolum Syntheticum: for conjunctival congestion and swelling pain, sore throat aphtha.Borneolum Syntheticum bitter cold, has the merit of clearing away heat to alleviate pain, detumescence, is department of eye common medicine.Treatment laryngopharynx swelling and pain, aphtha of the mouth and tongue, normal and Borax, Cinnabaris, Matrii Sulfas Exsiccatus grind to the powder altogether, blow deposited affected part, as BINGPENG SAN.Treatment acute pharyngitis due to wind-heat, swells and ache for skin infection, after bursting, does not hold back.This product also has heat-clearing and toxic substances removing, erosion prevention and muscle growing effect.It is the good medicine good merchantable brand of external curing oral ulcer.
Sucus Hoveniae: sweet; Flat.Return lung meridian.Function cures mainly: ward off dirty deodorization.Main bromhidrosis.
Radix Glycyrrhizae: property is flat, and sweet in the mouth, returns 12 warps.Invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, gastral cavity abdomen, the anxious pain of extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strongly have removing toxic substances, eliminate the phlegm, pain relieving, spasmolytic be so that the pharmacological action such as anticancer, Radix Glycyrrhizae has blood fat reducing, antioxidative effect.
Herba polygoni hydropiperis: pungent, temperature.Function cures mainly: expelling wind and removing dampness, eliminating stasis to stop pain, removing toxic substances and promoting subsidence of swelling, killing parasites for relieving itching.For dysentery, gastroenteritis, diarrhoea, rheumatic arthritis, treating swelling and pain by traumatic injury, dysfunctional uterine hemorrhage; Venom is controlled in external, skin eczema.
Ceiling grass: pungent; Property is put down.Return lung; Spleen channel.Function cures mainly: expelling wind and removing dampness; Promoting blood circulation and detumescence; Removing toxic substances hemostasis.Main Common Cold; Have loose bowels; Dysentery; Rheumatic ostalgia; Traumatic injury; Fracture; Carbuncle pyogenic infections from tumour or sore; Anal fistula; Venom; Spit blood; Epistaxis; Traumatic hemorrhage.
Flos Lonicerae: the loose poison of heat clearing away, Compendium of Material Medica is carried " Flos Lonicerae, is good at removing toxic substances, therefore control carbuncle, toxic swelling, skin ulcer tinea ... ".Since ancient times, Flos Lonicerae is usually used in heat-clearing and toxic substances removing, the heating for the treatment of epidemic febrile disease, toxic-heat and blood stasis, the diseases such as carbuncle and ulcer.Modern pharmacological research shows, that Flos Lonicerae has is antibacterial, antiviral, antiinflammatory, antipyretic, regulate the effect traditional Chinese medical science such as immunity to think, Flos Lonicerae is cold in nature, sweet in the mouth, gas are put down, and has effect of heat-clearing and toxic substances removing, can treat the disease such as pyretic toxicity abscess, carbuncle furuncle.And have the loose effect of a surname concurrently.Flos Lonicerae antipyretic and antidote functions is quite strong.Flos Lonicerae can delay the pathological changes effect of Respirovirus to cell, is the representative medicine of heat-clearing and toxic substances removing, and pyretic toxicity essence is except containing multiple pathogenic microorganism, and microbial toxin also accounts for critical positions.Flos Lonicerae preparation lumbar injection can obviously reduce the leukocyte count of rabbit due to the endotoxin of bacillus pyocyaneus and decline, and deviation to the left phenomenon etc. has obvious antagonism.Poisoning symptom and death that Flos Lonicerae compatibility Radix Scutellariae is prepared into preparation and can obviously alleviates bacillus pyocyaneus endotoxin caused rabbit.
Herba Meliloti Suaveolentis: another name: Herba medicaginis falcatae, Kochia scoparia, Herba boeae clarkeanae, Ocimum basilicum L. var. pilosum, wild peanut, Caput Gallus domesticus flowers and plants, chicken lousewort, Herba Meliloti officinalis, smelly Herba Medicaginis, the grass that relieves internal heat, fragrant horse material, Rhizoma aspidistrae luridae grass.Pungent; Sweet; Micro-hardship; Cool in nature.Return liver; Spleen; Stomach warp.Function cures mainly: clearing away summer-heat and eliminating dampness; Stomach invigorating and in.Main heat-damp in summer breast is vexed; Feeling of fullness in the head headache; Dysentery; Malaria; Stranguria; Leukorrhagia; Aphtha; Halitosis; Skin infection; Eczema; Scabies; Lymphoid tuberculosis.
Herba Ocimi (Herba Ocimi Pilosi): pungent, temperature.Function cures mainly: relieving the exterior syndrome by diaphoresis, expelling wind and removing dampness, eliminating stasis to stop pain.For anemofrigid cold, headache, pipe abdomen fullness, dyspepsia, stomachache, enteritis, diarrhea, treating swelling and pain by traumatic injury, rheumatic arthritis; Venom is controlled in external, eczema, dermatitis.
Radix Puerariae: sweet, pungent, cool.Return spleen, stomach warp.Function cures mainly: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, and rash, yang invigorating antidiarrheal.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels; Hypertension neck pain.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Poria 10-25 weight portion, Exocarpium Citri Rubrum 10-20 weight portion, Fructus Phyllanthi 10-20 weight portion, Radix Gentianae 10-20 weight portion, Oryza glutinosa 10-20 weight portion, Folium Et Cacumen Murrayae 15-25 weight portion, Rhizoma Curcumae 10-20 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Lignum Santali Albi 15-25 weight portion, Herba Menthae 10-20 weight portion, Borneolum Syntheticum 10-15 weight portion, Sucus Hoveniae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Herba polygoni hydropiperis 10-26 weight portion and ceiling grass 10-18 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Poria 14-22 weight portion, Exocarpium Citri Rubrum 13-18 weight portion, Fructus Phyllanthi 10-15 weight portion, Radix Gentianae 15-20 weight portion, Oryza glutinosa 15-20 weight portion, Folium Et Cacumen Murrayae 17-22 weight portion, Rhizoma Curcumae 13-17 weight portion, Radix Angelicae Dahuricae 13-17 weight portion, Lignum Santali Albi 18-22 weight portion, Herba Menthae 14-18 weight portion, Borneolum Syntheticum 12-15 weight portion, Sucus Hoveniae 12-18 weight portion, Radix Glycyrrhizae 13-20 weight portion, Herba polygoni hydropiperis 15-23 weight portion and ceiling grass 12-15 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can be preferably again: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions and ceiling grass 13 weight portions.
In described Chinese medicine composition, the parts by weight of each raw medicinal material are preferably: Poria 10-25 weight portion, Exocarpium Citri Rubrum 10-20 weight portion, Fructus Phyllanthi 10-20 weight portion, Radix Gentianae 10-20 weight portion, Oryza glutinosa 10-20 weight portion, Folium Et Cacumen Murrayae 15-25 weight portion, Rhizoma Curcumae 10-20 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Lignum Santali Albi 15-25 weight portion, Herba Menthae 10-20 weight portion, Borneolum Syntheticum 10-15 weight portion, Sucus Hoveniae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Herba polygoni hydropiperis 10-26 weight portion, ceiling grass 10-18 weight portion, Flos Lonicerae 10-20 weight portion, Herba Meliloti Suaveolentis 10-20 weight portion, Herba Ocimi (Herba Ocimi Pilosi) 10-20 weight portion and Radix Puerariae 10-20 weight portion.
In described Chinese medicine composition, the parts by weight of each raw medicinal material can also be preferably: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions, ceiling grass 13 weight portions, Flos Lonicerae 15 weight portions, Herba Meliloti Suaveolentis 18 weight portions, Herba Ocimi (Herba Ocimi Pilosi) 14 weight portions and Radix Puerariae 16 weight portions.
The preparation method of described Chinese medicine composition comprises the following steps:
The first step, Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae and Lignum Santali Albi are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, in proportion by the raw medicinal material except Herba Menthae and Borneolum Syntheticum in surplus stock medical material, mix, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, by Herba Menthae and Borneolum Syntheticum extraction by steam distillation, obtains crystal;
The 5th step, the crystal that the powder that the first step, second step and the 3rd step are obtained and the 4th step obtain mixes, and is screened into subsequently 80～120 object fine powder things, and the fine powder thing of acquisition is dropped in mixing and blending machine and stirred, and obtains described Chinese powder medicine.
Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.
Embodiment 1 powder 1
It is a kind of for driving the Chinese medicine composition that dog is smelly that the embodiment of the present invention provides, and the parts by weight of its each raw medicinal material are: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions and ceiling grass 13 weight portions.
The preparation method of Chinese medicine composition comprises the following steps:
The first step, Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae and Lignum Santali Albi are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 4 times of mixture quality obtaining be 90%, reflux was extracted after 3 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 90% of 2 times of the mixture quality obtaining again, and reflux was extracted after 1.5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, in proportion by the raw medicinal material except Herba Menthae and Borneolum Syntheticum in surplus stock medical material, mix, add the ethanol with respect to the determining alcohol 90% of 3 times of the mixture quality obtaining, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C, relative density is 1.22, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 3 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water dissolution of 1 times with respect to the mixture quality obtaining again, and heating decocts 1.5 hours again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, by Herba Menthae and Borneolum Syntheticum extraction by steam distillation, obtains crystal;
The 5th step, the crystal that the powder that the first step, second step and the 3rd step are obtained and the 4th step obtain mixes, and is screened into subsequently 100 object fine powder things, and the fine powder thing of acquisition is dropped in mixing and blending machine and stirred, and obtains described Chinese powder medicine.
Embodiment 2 powders 2
It is a kind of for driving the Chinese medicine composition that dog is smelly that the embodiment of the present invention provides, the parts by weight of its each raw medicinal material are: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions, ceiling grass 13 weight portions, Flos Lonicerae 15 weight portions, Herba Meliloti Suaveolentis 18 weight portions, Herba Ocimi (Herba Ocimi Pilosi) 14 weight portions and Radix Puerariae 16 weight portions.
The preparation method of Chinese medicine composition comprises the following steps:
The first step, Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae and Lignum Santali Albi are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 5 times of mixture quality obtaining be 90%, reflux was extracted after 3 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 90% of 1 times of the mixture quality obtaining again, and reflux was extracted after 1.5 hours, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.8g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, in proportion by the raw medicinal material except Herba Menthae and Borneolum Syntheticum in surplus stock medical material, mix, add the ethanol with respect to the determining alcohol 90% of 3 times of the mixture quality obtaining, heating and refluxing extraction 2 times, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 65 DEG C, relative density is 1.20, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2 times with respect to the mixture quality obtaining, and heating decocts 3 hours, filters; Filtering residue is used to the water dissolution of 2 times with respect to the mixture quality obtaining again, and heating decocts 2 hours again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, by Herba Menthae and Borneolum Syntheticum extraction by steam distillation, obtains crystal;
The 5th step, the crystal that the powder that the first step, second step and the 3rd step are obtained and the 4th step obtain mixes, and is screened into subsequently 80～120 object fine powder things, and the fine powder thing of acquisition is dropped in mixing and blending machine and stirred, and obtains described Chinese powder medicine.
Toxicity test
Acute toxicity test: 60 of application NIH mices, SPF level, male and female half and half, body weight 17～24g, carries out acute toxicity test.Mice is divided into two groups at random, and 20 every group, i.e. matched group and administration group, fasting 12 hours before experiment; Powder prepared by embodiments of the invention 2 is dissolved in water, (concentration is 5.74g crude drug/ml, maximum concentration) gavage, gavage volume is that 5ml/kg(is that single-dose dosage is 28.7 crude drugs/kg), matched group gives equivalent normal saline, administration in a day 2 times, delivery time 6 hours, Continuous Observation 14 days after administration, and record mice toxic reaction and death toll.Experimental result shows: with matched group comparison, after administration, mice has no notable difference, experiment Continuous Observation 14 days, and mice overall health of patients, diet, drinking-water, body weight gain are all normal.Therefore Chinese medicine composition acute toxicity of the present invention is low, clinical drug safety.
Long term toxicity test: by the powder of the embodiment of the present invention 2 to mice by 6.43,15.72 and 16 weeks (1.0ml/100g body weight of 36.41g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine composition of the present invention to mice, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and Organs of Mice is all without obviously changing.Illustrate that toxicity is little after Chinese medicine composition of the present invention is to mice long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.
Acute dermal toxicity test: according to Ministry of Public Health " cosmetics health specification " (2002) Part II " acute dermal toxicity test " test method(s) of once limiting the quantity, 20 of SD rats, male and female half and half, body weight 90g～180g, the powder that the embodiment of the present invention 1 is obtained, add 400g rubber, 400g Colophonium to make coating, one time percutaneous is smeared 5000mg/kg body weight dosage, observe 15 days, do not find obvious poisoning symptom, nothing death, animal gross anatomy no abnormality seen, judges that these product are to the nontoxic level in the true border of rat acute percutaneous toxicity.
Acute skin irritation test: according to 6.3 joints in Ministry of Public Health " cosmetics health specification " (2002) Part II " skin irritation/corrosion test ", male 4 of Japan large ear rabbit, body weight 2kg～3kg, according to the method for above-mentioned " acute dermal toxicity test ", the powder of the embodiment of the present invention 2 is prepared to coating, then getting 0.5g directly spreads upon on the skin of animal left side (opposite side in contrast), adopt blocking test, 4 hours application time, after off-test, use the residual tested material of warm water washing, 1h after removing tested material, 24h, 48h and 72h observe respectively the dermoreaction of the tested district of animal and check plot, top average is " 0 ", judge that these product are to animal skin nonirritant.
The Chinese medicine composition composition powders of embodiment of the present invention 1-2 is used for driving dog when smelly, and powder is dissolved in water according to percentage by weight 1:50-150, have a bath for pet dog, and 1-2 time weekly, use continuously 1-2 week, can drive dog smelly; The first use of suggestion or stink are strong, prepare bathing solution according to the proportioning of 1:50, and 2 times weekly, use continuously after two weeks, use the proportioning of 1:150 instead and prepare bathing solution, every two weeks 1-2 time.
Application test and effect: in August, 2012 Jinan City, Shandong Province pet dog cultivation base, due to weather agitation, mosquito louse is more, and can not have a bath in time, as flea, the parasites such as acarid are more, have at least 37 Papillon healths obviously smelly, select wherein 36 Papillons that stink is strong, be divided at random three groups, for embodiment group 1, embodiment group 2 and matched group, use respectively the solution of the powder 1 that adds the embodiment of the present invention 1, the solution and the clear water that add the powder 2 of embodiment 2 carry out bathing, twice weekly, use two weeks continuously, Continuous Observation one week after last bathing, be divided into according to abnormal flavour degree difference: there is no abnormal flavour, abnormal flavour is lighter, abnormal flavour is strong.Wherein, the bathing solution of embodiment group 1 is dissolved in powder 1 in clear water according to the ratio of 1:100, and the bathing solution of embodiment group 2 is dissolved in powder 2 in clear water according to the ratio of 1:100; Statistical result is as follows: 12 Papillons in embodiment group 1, and 2 abnormal flavour are lighter, and 10 do not have abnormal flavour; 12 Papillons of embodiment group 2 all do not have abnormal flavour substantially, and in 12 Papillons of matched group, 2 Papillon abnormal flavour are lighter, and other 10 Papillon stinks are strong.In embodiment group 1 and embodiment group 2, there is no the Papillon of abnormal flavour, continue to use respectively powder 1 and powder 2 bathings, all prepare bathing solution according to the proportioning of 1:150, every two weeks 1 time, use continuously 5 months, all can keep clean free from extraneous odour.
The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.
Claims (8)
1. for driving the Chinese medicine composition that dog is smelly, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae, Lignum Santali Albi, Herba Menthae, Borneolum Syntheticum, Sucus Hoveniae, Radix Glycyrrhizae, Herba polygoni hydropiperis and ceiling grass.
2. according to claim 1 for driving the Chinese medicine composition that dog is smelly, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Poria 10-25 weight portion, Exocarpium Citri Rubrum 10-20 weight portion, Fructus Phyllanthi 10-20 weight portion, Radix Gentianae 10-20 weight portion, Oryza glutinosa 10-20 weight portion, Folium Et Cacumen Murrayae 15-25 weight portion, Rhizoma Curcumae 10-20 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Lignum Santali Albi 15-25 weight portion, Herba Menthae 10-20 weight portion, Borneolum Syntheticum 10-15 weight portion, Sucus Hoveniae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Herba polygoni hydropiperis 10-26 weight portion and ceiling grass 10-18 weight portion.
3. according to claim 1 and 2 for driving the Chinese medicine composition that dog is smelly, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Poria 14-22 weight portion, Exocarpium Citri Rubrum 13-18 weight portion, Fructus Phyllanthi 10-15 weight portion, Radix Gentianae 15-20 weight portion, Oryza glutinosa 15-20 weight portion, Folium Et Cacumen Murrayae 17-22 weight portion, Rhizoma Curcumae 13-17 weight portion, Radix Angelicae Dahuricae 13-17 weight portion, Lignum Santali Albi 18-22 weight portion, Herba Menthae 14-18 weight portion, Borneolum Syntheticum 12-15 weight portion, Sucus Hoveniae 12-18 weight portion, Radix Glycyrrhizae 13-20 weight portion, Herba polygoni hydropiperis 15-23 weight portion and ceiling grass 12-15 weight portion.
According to described in claim 1-3 any one for driving the Chinese medicine composition that dog is smelly, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions and ceiling grass 13 weight portions.
According to described in claim 1-4 any one for driving the Chinese medicine composition that dog is smelly, it is characterized in that, described Chinese medicine composition also comprises: Flos Lonicerae, Herba Meliloti Suaveolentis, Herba Ocimi (Herba Ocimi Pilosi) and Radix Puerariae.
According to described in claim 1-5 any one for driving the Chinese medicine composition that dog is smelly, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Poria 10-25 weight portion, Exocarpium Citri Rubrum 10-20 weight portion, Fructus Phyllanthi 10-20 weight portion, Radix Gentianae 10-20 weight portion, Oryza glutinosa 10-20 weight portion, Folium Et Cacumen Murrayae 15-25 weight portion, Rhizoma Curcumae 10-20 weight portion, Radix Angelicae Dahuricae 10-20 weight portion, Lignum Santali Albi 15-25 weight portion, Herba Menthae 10-20 weight portion, Borneolum Syntheticum 10-15 weight portion, Sucus Hoveniae 10-20 weight portion, Radix Glycyrrhizae 10-20 weight portion, Herba polygoni hydropiperis 10-26 weight portion, ceiling grass 10-18 weight portion, Flos Lonicerae 10-20 weight portion, Herba Meliloti Suaveolentis 10-20 weight portion, Herba Ocimi (Herba Ocimi Pilosi) 10-20 weight portion and Radix Puerariae 10-20 weight portion.
According to described in claim 1-6 any one for driving the Chinese medicine composition that dog is smelly, it is characterized in that, in described Chinese medicine composition, the parts by weight of each raw medicinal material are: Poria 18 weight portions, Exocarpium Citri Rubrum 14 weight portions, Fructus Phyllanthi 13 weight portions, Radix Gentianae 18 weight portions, Oryza glutinosa 17 weight portions, Folium Et Cacumen Murrayae 19 weight portions, Rhizoma Curcumae 15 weight portions, the Radix Angelicae Dahuricae 15 weight portions, Lignum Santali Albi 20 weight portions, Herba Menthae 16 weight portions, Borneolum Syntheticum 14 weight portions, Sucus Hoveniae 15 weight portions, Radix Glycyrrhizae 17 weight portions, Herba polygoni hydropiperis 19 weight portions, ceiling grass 13 weight portions, Flos Lonicerae 15 weight portions, Herba Meliloti Suaveolentis 18 weight portions, Herba Ocimi (Herba Ocimi Pilosi) 14 weight portions and Radix Puerariae 16 weight portions.
According to described in claim 1-6 any one for driving the preparation method of the Chinese medicine composition that dog is smelly, it is characterized in that, the dosage form of described Chinese medicine composition is powder, described preparation method comprises the following steps:
The first step, Poria, Exocarpium Citri Rubrum, Fructus Phyllanthi, Radix Gentianae, Oryza glutinosa, Folium Et Cacumen Murrayae, Rhizoma Curcumae, the Radix Angelicae Dahuricae and Lignum Santali Albi are mixed in described ratio, the dissolve with ethanol that to use with respect to the determining alcohol of 3～5 times of mixture quality obtaining be 85%～95%, reflux was extracted after 2～4 hours, filter, obtain the first filtrate; Filtering residue is used to the dissolve with ethanol with respect to the determining alcohol 85%～95% of 1～2 times of the mixture quality obtaining again, and reflux was extracted after 1～2 hour, filtered, and obtained the second filtrate; Merge the first filtrate and the second filtrate, decompression recycling ethanol to be concentrated into liquor strength be 0.7～0.9g crude drug/mL, the macroporous adsorptive resins eluting that is 5L through volume, first use deionized water or the distilled water eluting of 5 times of resin column volumes, be 90%～95% ethanol elution with the determining alcohol of 3 times of resin column volumes again, collect ethanol elution, concentrating under reduced pressure is removed ethanol, is dried and is ground into powder;
Second step, in proportion by the raw medicinal material except Herba Menthae and Borneolum Syntheticum in surplus stock medical material, mix, add the ethanol with respect to the determining alcohol 85%～95% of 2～4 times of the mixture quality obtaining, heating and refluxing extraction 1～2 time, extracting solution merges, with the centrifugal remove impurity of tube centrifuge, the mastic that when extracting solution after remove impurity is evaporated to 60 DEG C under the condition of 60 DEG C～70 DEG C, relative density is 1.20～1.23, is dried to powder by the mastic after concentrated with spray dryer;
The 3rd step, mixes surplus stock medical material in described ratio, add the water dissolution of 2～4 times with respect to the mixture quality obtaining, and heating decocts 2～4 hours, filters; Filtering residue is used to the water dissolution of 1～2 times with respect to the mixture quality obtaining again, and heating decocts 1～2 hour again, filters; Merge the filtrate of twice, concentrating under reduced pressure is removed moisture, is dried and is ground into powder;
The 4th step, by Herba Menthae and Borneolum Syntheticum extraction by steam distillation, obtains crystal;
The 5th step, the crystal that the powder that the first step, second step and the 3rd step are obtained and the 4th step obtain mixes, and is screened into subsequently 80～120 object fine powder things, and the fine powder thing of acquisition is dropped in mixing and blending machine and stirred, and obtains described Chinese powder medicine.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106283619A (en) * | 2016-08-23 | 2017-01-04 | 南通康华化工有限公司 | A kind of clothing deodorizer |
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| CN102102053A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Perfumed soap for dog |
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| CN1460500A (en) * | 2003-06-13 | 2003-12-10 | 崔延堂 | Fragrance body health-care product |
| CN101167685A (en) * | 2006-10-29 | 2008-04-30 | 刘长弟 | Pet peculiar smell deodorizing agent |
| CN101473906A (en) * | 2009-01-20 | 2009-07-08 | 天津市伯曼宠物饲料有限公司 | Nutritive composition for reducing production of bad odour from pet |
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