CN113456774A

CN113456774A - Composition for dispelling effects of alcohol and protecting liver and preparation method thereof

Info

Publication number: CN113456774A
Application number: CN202110909082.1A
Authority: CN
Inventors: 郑涵; 杨继广; 席宾; 李朝阳; 刘春颖
Original assignee: Flower Of Life Beijing Health Management Co ltd
Current assignee: Flower Of Life Beijing Health Management Co ltd
Priority date: 2021-08-09
Filing date: 2021-08-09
Publication date: 2021-10-01

Abstract

The invention belongs to the technical field of anti-alcoholism Chinese herbal medicines, and discloses an anti-alcoholism and liver-protecting composition and a preparation method thereof. The composition takes fructus Alpinae Oxyphyllae as monarch drug, has warm property and spleen and kidney meridians regulating effect, and can be used for regulating incoordination between spleen and stomach caused by alcohol, warming spleen and kidney, reducing emesis, and further reducing gastric acid secretion; the kudzuvine root and the hovenia dulcis are used as ministerial drugs, which belong to the drugs with sweet taste, and have the effects of relieving alcoholism, quenching thirst due to yin deficiency, and diarrhea due to spleen deficiency, protecting and nourishing the liver, and preventing alcoholism; herba Lophatheri has effects of clearing heat and fire, promoting fluid production of fructus Canarii albi to quench thirst, regulating middle warmer and invigorating spleen with pericarpium Citri Tangerinae, dispersing stagnated liver qi and dispelling pathogenic fire with fructus Citri Sarcodactylis and semen Pruni, and Perillae herba has effects of accelerating gastrointestinal digestion and promoting metabolism; the Chinese herbal medicines are used as adjuvant medicines, mainly regulate the three meridians of spleen, stomach and liver, and play the roles of dredging the triple energizer, promoting the dispelling of melancholy, expelling liver toxin, protecting intestines and stomach, dispelling the effects of alcohol and protecting liver.The preparation method adopts stir-frying and pulverizing, helps to extract effective components in subsequent decoction, realizes maximum degree of drug effect fusion, ensures drug effect, has no toxic and side effects, and meets the requirement that the content of effective components is lower than that of mouse gavage LD₅₀And (4) standard amount.

Description

Composition for dispelling effects of alcohol and protecting liver and preparation method thereof

Technical Field

The invention belongs to the technical field of anti-alcoholism Chinese herbal medicines, and particularly relates to an anti-alcoholism and liver-protecting composition and a preparation method thereof.

Background

The wine culture of China has the characteristics of durability, and the wine can not be drunk by wedding, funeral and celebration, even friends and negotiations, so that the wine can be drunk for feast and can not be drunk for banquet. However, there are increasing cases of intoxication and liver damage caused by the same, and diseases such as cerebral nerve degeneration, cardiovascular disease, and liver cirrhosis are positively correlated with drinking. However, because of the Yuan history of liquor culture in China, people cannot completely deal with liquor, so that the research on the health-care food with the functions of dispelling the effects of alcohol and protecting the liver is very necessary to protect the health of human bodies.

After drinking, one quarter of the alcohol is absorbed directly by the stomach, which causes the capillary vessel of the stomach wall to dilate, causing satiety, and meanwhile, affecting the normal peristalsis of the stomach, resulting in vomiting. In addition, alcohol catabolism in the human body is mainly dependent on the enzymatic and circulatory systems of the liver. When the liver is not smooth, people have intoxication symptoms such as nausea, vomiting and coma after drinking. Intoxication can also occur if excessive or too fast drinking exceeds the ability of the liver to self-decompose.

In recent years, there have been many reports and products on medical and health foods, beverages and medicines for alleviating hangover: the related patents disclose that Chinese magnoliavine fruit, dried orange peel, ginger, dark plum fruit, bitter apricot seed, tuckahoe and mulberry leaf are adopted to prepare a traditional Chinese medicine formula for relieving alcoholism and protecting liver; related patent publications application a tabletted candy formulated with artichoke extract, hovenia dulcis thunb extract, white hyacinth bean, kudzu root, sorbitol, ascorbic acid, mannitol and magnesium stearate. However, the anti-inebriation products with different formulas have greatly different effects, the content of active substances of some traditional Chinese medicine components is low, the good anti-inebriation and liver protection effects cannot be achieved, and even traditional Chinese medicines with definite hepatotoxicity are used as the components.

Most products on the market have the defects of more indications, wide treatment range, undefined curative effect, weak pertinence and the like. And a part of products are hangover-alleviating and liver-protecting tea, theophylline in the tea can cause undecomposed acetaldehyde to enter the kidney too early and too fast, and the acetaldehyde has a great stimulation effect on the kidney, so that the product dosage form is also a part of hangover-alleviating and liver-protecting products.

According to traditional Chinese medicine, wine is hot in qi and wet in nature. The Huangdi's classic has a record of the pathogenesis of excessive drinking, and the plain questions, ancient Tianzhen treatises on cloud: "it is half a hundred times weaker because it takes alcohol as the plasma and goes into the house to exhaust its essence … …. It is also superficial in onset, or vomiting, spontaneous sweating, sores, scabies, rosacea, diarrhea, or cardialgia and splenalgia, and it may also disperse; it is also deeply ill for a long time, or it is diabetes, deep carbuncle, consumptive lung disease, anal fistula, tympanites, jaundice, blindness, asthma, chronic cough, epistaxis, epilepsy, and intractable disease, and is not easy to treat unless it is high-minded.

Based on the above, the anti-alcohol and liver-protecting preparation which is based on the mechanism of alcohol-damaged liver, spleen and stomach, protects liver, spleen and stomach, accelerates alcohol metabolism and relieves discomfort after drinking on the premise of ensuring that the body does not suffer from alcoholism becomes a problem which is in urgent need of research

Disclosure of Invention

In order to solve the problems in the prior art, the invention aims to provide a composition for relieving alcoholism and protecting liver and a preparation method thereof.

The technical scheme adopted by the invention is as follows: the composition is mainly prepared from the following raw materials in parts by mass:

6-9 parts of lophatherum gracile, 4.5-9 parts of Chinese olive, 3-10 parts of orange peel, 3-9 parts of fructus alpiniae oxyphyllae, 3-10 parts of fingered citron, 3-10 parts of bunge cherry seed, 5-10 parts of purple perilla, 9-15 parts of root of kudzu vine and 9-15 parts of hovenia dulcis.

Lophatherum gracile, the name of Chinese medicine. Is dried stem and leaf of Lophatherum gracile Brongn of Lophatherum of Gramineae. Has effects of clearing heat-fire, relieving restlessness, and promoting urination. It can be used for treating fever, polydipsia, aphtha, dark urine, pyretic stranguria, and odynuria. Sweet and light taste, cold in nature; it enters heart, stomach and small intestine meridians. The product contains triterpenes such as arundoin, imperatorin, taraxasterol, and steroids such as beta-sitosterol, stigmasterol, campesterol, taraxasterol, etc. The product has antipyretic effect; it has diuretic effectThe output of chloride in urine is stronger when the urine is weaker; the crude extract has anti-tumor effect; the decoction has inhibitory effect on Staphylococcus aureus and hemolytic streptococcus. In addition, it also has blood sugar increasing effect. Lophatherum gracile LD for mice₅₀It was 64.5 g/kg.

Chinese medicine name of Chinese olive. Is dried mature fruit of Canarium album Raeusch of Terminalia of Combretaceae. Has the effects of clearing away heat and toxic materials, relieving sore throat and promoting fluid production. Can be used for treating swelling and pain of throat, cough, polydipsia, fish and crab poisoning. Sweet and sour in taste and mild in nature; it enters lung and stomach meridians. Chemical components: the fruit of the product contains protein, fat, carbohydrate, calcium, phosphorus, iron, ascorbic acid, etc.; the seed contains volatile oil and resinol. The pharmacological action is as follows: the Chinese olive extract has protective effect on hepatosis caused by the galactose amine; can also relieve the damage of carbon tetrachloride to liver. It can excite salivary glands to increase salivary secretion, so it is helpful for digestion. Compendium of materia Medica: "Shengjinye" can stop polydipsia and treat sore throat. When the throat juice is chewed, all fish and turtle toxins can be removed. ".

Orange peel, named as traditional Chinese medicine. Also known as pericarpium Citri Tangerinae, mature pericarp of Rutaceae plant fructus Citri Tangerinae and its cultivar. Compendium (compendium): orange peel, bitter in flavor and purging in property can dry, pungent in flavor and dispersing in property and warm in property. For all kinds of diseases, it is always used to regulate qi and dry dampness, tonics are used to tonify qi, purgatives are used to purge qi, ascending qi and descending qi. The spleen is the mother of original qi and the lung is the key of qi absorption, so orange peel is the key of qi of the two meridians, but it can tonify and purge ascending and descending along with it. "nature and taste: warm in nature, pungent and bitter in flavor. Meridian tropism: enter spleen, stomach and lung meridians. The main treatment effects are as follows: regulate qi-flowing for strengthening spleen, regulate middle energizer, dry dampness and resolve phlegm. It can be used for treating abdominal distention, pain, and dyspepsia due to qi stagnation of spleen and stomach. Chest oppression, abdominal distension, poor appetite and loose stool due to damp-turbidity obstruction. Cough and dyspnea due to phlegm-dampness obstructing the lung. Can be used for treating fullness in chest and abdomen, anorexia, vomiting, diarrhea, cough, and excessive phlegm. Chenpi is warm in nature and can nourish spleen, pungent in nature and bitter in nature can invigorate spleen. Because Chen Pi governs qi movement of spleen and stomach, spleen and stomach are in the middle energizer and qi of middle energizer passes through, qi of triple energizer also surges. The triple energizer is the organ of profanity and governs dampness to pass water.

Fructus Alpinae Oxyphyllae, named as Chinese medicine. Is fruit of Alpinia oxyphylla Miq. of Alpinia of Zingiberaceae. Has effects of warming spleen, relieving diarrhea, arresting salivation, warming kidney, reducing urination, and stopping nocturnal emission. Can be used for treating deficiency cold of spleen and stomach, emesis, diarrhea, abdominal psychroalgia, excessive saliva, enuresis due to kidney deficiency, pollakisuria, spermatorrhea, and whitish and turbid urine. Pungent taste and warm nature; it enters spleen and kidney meridians. Chemical components: contains dibenzo-p-phenylene, sesquiterpenoids and volatile oil. The pharmacological action is as follows: 1. effects on the cardiovascular system: the methanol extract of Alpinia oxyphylla has the effect of enhancing the contractile activity of the left atrium, thereby having the cardiotonic effect. The methanol extract of fructus Alpinae Oxyphyllae has calcium antagonistic effect and can be used for treating large blood vessel contraction, but has no influence on contraction caused by norepinephrine. 2. Effects on the digestive system: the aqueous extract and ethanol extract of fructus Alpinae Oxyphyllae have effects of inhibiting ileum contraction. 3. Effects on the reproductive system: the methanol extract of Alpinia oxyphylla can inhibit the activity of prostaglandin synthetase. 4. Effect of enhancing energy metabolism: the compound preparation of fructus alpiniae oxyphyllae, named Yizhi syrup, can improve energy metabolism. 5. In addition, fructus Alpinae Oxyphyllae also has anticancer, antiaging, and memory improving effects.

Fingered citron, the name of traditional Chinese medicine. Is dried fruit of Citrus medica L.var.sarcodactylis Swingle belonging to Citrus of Rutaceae. Has the effects of soothing liver-qi stagnation, regulating qi, regulating the middle warmer, eliminating dampness and phlegm. Is mainly used for treating liver depression and qi stagnation, chest and hypochondrium distending pain caused by liver-stomach disharmony, abdominal fullness and distention, abdominal distending pain caused by spleen-stomach qi stagnation, nausea, poor appetite, cough with profuse sputum for a long time, and chest pain caused by falsework. Pungent, bitter and sour taste, warm in nature; it enters liver, spleen and stomach meridians. Chemical components: contains volatile oil, flavonoids, polysaccharides, and coumarins. The main components include bergapten, lemon lactone, hesperidin, buciloside (diosmin), etc. The pharmacological action is as follows: 1. effects on the central nervous system: the ethanol extract of the fingered citron is injected into the abdominal cavity of a mouse, the spontaneous activity is obviously reduced, the sleep time of pentobarbital sodium of the mouse can be obviously prolonged, and the death time of strychnine convulsion of the mouse can be prolonged. 2. Impact on the respiratory system: the fructus Citri Sarcodactylis decoction can resist in vitro tracheal contraction of guinea pig caused by histamine. The limonolide separated from fructus Citri Sarcodactylis has effect in resisting guinea pig in vitro trachea contraction caused by histamine. 3. Effects on the cardiovascular system: the alcohol extract of fingered citron can obviously increase the coronary flow of the isolated heart of the guinea pig and improve the hypoxia tolerance of the mouse, and also has the protection effect on the myocardial ischemia of the rat caused by the hypophysin. It can be used for preventing arrhythmia induced by chloroform-epinephrine. The alcohol extract has certain heart inhibiting and blood pressure lowering effects in anesthetized cats by intravenous injection. 4. Effects on the digestive tract: the finger citron alcohol extract has obvious inhibiting effect on in vitro intestinal tracts of rats and rabbits, and in vivo intestinal tracts of anesthetized cats and rabbits. 5. In addition, fingered citron has certain anti-inflammatory, antiviral, anticoagulant and hemostatic effects.

Bunge cherry seed, the name of traditional Chinese medicine. Is seed of Prunus humilis Bunge, Prunus japonica Thunb, Prunus japonica Lindl, Prunus ulmaria Bungriffith Lindl, and Prunus pedunculata Maxim of Prunus of Rosaceae. Has effects of loosening bowel to relieve constipation, descending qi, promoting urination and relieving swelling. It can be used for treating constipation due to intestinal dryness, edema, and edema of loempe. Pungent, bitter, sweet and neutral in flavor; it enters spleen, large and small intestine meridians. Chemical components: 1. the Chinese dwarf cherry: the seed contains amygdalin, bungeanin A, B, and 2 protein components IR-A and IR-B are also isolated. The fresh fruit contains rose-glycoside A, B, i.e. bunge cherry seed glycoside A, B, and further contains ursolic acid, vanillic acid, protocatechuic acid, afzel glycoside, resurrection lily rhizome glycoside, and rose glycoside A. 2. European plum: the seeds contain amygdalin, bunge cherry seed glycoside A, B. 3. The long-stem bunge cherry: the seeds contain amygdalin, bunge cherry seed glycoside A, B. 4. Leaf of hairy Prunus humilis: the seeds contain amygdalin, bunge cherry seed glycoside A, B. The pharmacological action is as follows: 1. action on digestive system: semen Pruni has effects of moistening intestine and promoting small intestine peristalsis. 2. Other functions are as follows: semen Pruni has antiinflammatory, analgesic, antitussive and expectorant effects.

Purple perilla, name of traditional Chinese medicine. Is stem and leaf of Perilla Perillarietescens (L.) Britt. of Perilla of Labiatae. Its leaves are called perilla leaves, and its stems are called perilla stems. Has effects of relieving exterior syndrome, dispelling cold, promoting qi circulation, relieving epigastric distention, preventing miscarriage, and relieving fish and crab toxin. It can be used for treating wind-cold type common cold, qi stagnation of spleen and stomach, chest distress, emesis, fetal qi adverse rising, threatened abortion, seven emotions stagnation, phlegm stagnation, and syphilis, abdominal pain, emesis, and diarrhea due to poisoning of fish and crab. Pungent and spicy taste, slight heat in property; entering the cold channel. Contains volatile oil, which mainly contains perillaldehyde, levolimonene and a small amount of alpha-pinene. 1. Bacteriostasis: has different degrees of inhibition effects on staphylococcus, streptococcus, typhoid bacteria, large intestine bacteria, dysentery bacteria, diphtheria bacillus, meningococcus, catacoccus, influenza virus and candida albicans. Can inhibit growth of filamentous fungi on skin. 2. The antipyretic effect is as follows: it can dilate skin blood vessel, stimulate sweat gland secretion and relieve fever. 3. Effects on the central nervous system: the water extract and perillaldehyde can prolong sleep time of barbiturate in male mouse, and has effects of inhibiting upper larynx nerve reflex of cat, and inhibiting excitability membrane of snail nerve cell and frog sciatic nerve fiber. The aqueous extract can inhibit the exercise capacity of rats. Perillaldehyde has tranquilizing effect. 4. Impact on the respiratory system: can reduce bronchial secretion, relieve bronchospasm, and has significant effect of relieving cough caused by acrolein or citric acid, and mouse phenol red test shows positive effect, so it can be proved that Perillae herba has effects of eliminating phlegm, relieving cough and relieving asthma. 5. Effects on the digestive system: can promote secretion of digestive juice and increase gastrointestinal motility. 6. Effects on the reproductive system: can inhibit uterine contraction and prevent miscarriage. 7. Effects on metabolism: on the premise of feeding nitrogen foods with equal calorie and the like, the weight, the liver weight, the plasma cholesterol, the liver cholesterol, the blood sugar and the acid phosphate activity of the rabbits fed with perilla oil are increased to different degrees compared with those of the control group. 8. Hemostasis effect: the Perillae herba can shorten blood coagulation time, blood plasma recalcification time and thrombin activating time.

Kudzu root, name of Chinese traditional medicine. Is dried root of Ohwi of Pueraria lobata (Willd.) Ohwi of Pueraria of Leguminosae. Has the effects of expelling pathogenic factors from muscles, relieving fever, promoting eruption, promoting salivation, quenching thirst, invigorating yang, and relieving diarrhea. It can be used for treating fever, stiffness and pain of neck and back, measles without adequate eruption, thirst due to fever, diabetes due to yin deficiency, dysentery due to heat-purging, and diarrhea due to spleen deficiency. Nature, flavor and meridian tropism: sweet and pungent in flavor and cool in nature; it enters spleen and stomach meridians.

Hovenia dulcis Thunb, named as traditional Chinese medicine. Is prepared from Hovenia adulcisco Thunb of Hovenia of Rhamnaceae by using bark and seed as raw materials. Has the following components: clear heat and induce diuresis, relieve cough and restlessness, and relieve alcoholism. Bark: promote blood circulation, relax muscles and tendons and remove toxicity. Fruit stem: invigorate stomach and nourish blood. The main curing seeds: can be used for treating fever, polydipsia, singultus, emesis, dysuresia, and alcoholism. Bark: can be used for treating gastrocnemius spasm, food stagnation, and hammer poisoning. Fruit stem: steaming and soaking in wine for nourishing and tonifying blood. Nature, flavor and meridian tropism: sweet in flavor and neutral in nature. The main treatment is as follows: 1. a step of: can be used for treating fever, polydipsia, singultus, emesis, dysuresia, and alcoholism. 2. Bark: can be used for treating gastrocnemius spasm, food stagnation, and hammer poisoning. 3. Fruit stem: steaming and soaking in wine for nourishing and tonifying blood.

Preferably, the composition is mainly prepared from the following raw materials in parts by mass:

6.5-8.5 parts of lophatherum gracile, 5-8 parts of Chinese olive, 5-8 parts of orange peel, 4-8 parts of fructus alpiniae oxyphyllae, 5-8 parts of fingered citron, 5-8 parts of bunge cherry seed, 7-9 parts of purple perilla, 10-14 parts of radix puerariae and 10-14 parts of hovenia dulcis thunb.

8 parts of lophatherum gracile, 7 parts of Chinese olive, 6 parts of orange peel, 5 parts of fructus alpiniae oxyphyllae, 6 parts of fingered citron, 6 parts of bunge cherry seed, 8 parts of purple perilla, 12 parts of radix puerariae and 12 parts of hovenia dulcis thunb.

A method for preparing a composition for relieving hangover and protecting liver comprises selecting fructus Canarii albi, fructus Alpinae Oxyphyllae, fructus Citri Sarcodactylis, semen Pruni, radix Puerariae and Japanese raisin Tree according to corresponding proportion, mixing, parching in an iron pan, coarse pulverizing, adding folium Bambusae, pericarpium Citri Tangerinae, Perillae herba and solvent, decocting, and filtering to remove residue to obtain the final product.

Preferably, when the stir-frying is carried out in an iron pan, the stir-frying temperature is 110-;

the frying time is 3-10 minutes.

Preferably, the particle size after coarse crushing is 80-100 meshes.

Preferably, the solvent is water.

Preferably, the mass ratio of the total mass of the Chinese olive, the fructus alpiniae oxyphyllae, the fingered citron, the bunge cherry seed, the root of kudzu vine, the hovenia dulcis, the lophatherum gracile, the orange peel and the perilla to the solvent is 1: 10-15.

Preferably, the decoction temperature is 90-100 ℃;

the decoction time is 40-85 minutes.

Preferably, the finished product is an oral preparation.

The invention has the beneficial effects that:

the invention provides a composition for relieving alcoholism and protecting liver, which takes sharpleaf galangal fruit as a monarch drug, has warm property and spleen and kidney meridians, is firstly used for adjusting the problem of incoordination between the spleen and the stomach caused by alcohol, warms the spleen and the kidney, reduces vomiting and further reduces the secretion of gastric acid; the kudzuvine root and the hovenia dulcis thunb are used as ministerial drugs, belong to the taste sweet drugs, and are used for relieving alcoholism, quenching thirst due to yin deficiency and diarrhea due to spleen deficiency, so as to achieve the effects of protecting and nourishing the liver and preventing alcoholism; herba Lophatheri has effects of clearing heat and fire, promoting fluid production of fructus Canarii albi to quench thirst, regulating middle warmer and invigorating spleen with pericarpium Citri Tangerinae, dispersing stagnated liver qi and dispelling pathogenic fire with fructus Citri Sarcodactylis and semen Pruni, and Perillae herba has effects of accelerating gastrointestinal digestion and promoting metabolism; lophatherum gracile, Chinese olive, orange peel, fingered citron, bunge cherry seed and purple perilla are used as adjuvant drugs, mainly regulate the three channels of spleen, stomach and liver, and play a role in activating triple warmer, promoting depression, expelling liver toxin, protecting intestines and stomach, and further completing the functions of dispelling the effects of alcohol and protecting liver.

In the preparation method, the Chinese olive, the fructus alpiniae oxyphyllae, the fingered citron, the bunge cherry seed, the root of kudzu vine and the hovenia dulcis are fried in a high-temperature mode, and are crushed, so that the method is favorable for improving the precipitation rate of effective components in the subsequent decoction process and realizing the maximum degree of drug effect fusion of the effective components with the lophatherum gracile, the orange peel and the purple perilla, the drug effect is ensured, no toxic or side effect is caused, and the finished product meets the condition that the content of the effective components is lower than that of mouse gastric perfusion LD (laser diode)₅₀And (4) standard amount.

Detailed Description

The present invention is further illustrated below with reference to specific examples. It will be appreciated by those skilled in the art that the following examples, which are set forth to illustrate the present invention, are intended to be part of the present invention, but not to be construed as limiting the scope of the present invention. The reagents used are all conventional products which are commercially available.

Example 1:

a preparation method of a composition for relieving alcoholism and protecting liver comprises the steps of selecting 4.5g of Chinese olive, 3 g of sharpleaf galangal fruit, 3 g of finger citron, 3 g of bunge cherry seed, 9 g of kudzuvine root and 9 g of hovenia dulcis thunb according to corresponding proportions, mixing, frying for 10 minutes at 110 ℃ in an iron pan, screening by a 80-mesh screen after coarse crushing, adding 6 g of lophatherum gracile, 3 g of orange peel, 5g of perilla and 682.5 g of water, decocting for 85 minutes at 90 ℃, and filtering residues to obtain a finished product.

When above-mentioned filtering residue, optional traditional chinese medicine filtration equipment, the filter equipment who chooses for use includes microporous membrane filter, stainless steel, the pattern: tubular, manufacturer: sitepu filtration equipment, Inc., New county. The selection of the filtering device is not limited to the above, and all devices which can complete the corresponding filtering work and have no influence on raw materials belong to the protection scope of the invention.

In the actual operation process of all the embodiments, the crusher used in the coarse crushing is a small-sized flow crusher, and the type is as follows: FS-6D, manufacturer: and a manufacturer of the Jinan flying mechanical equipment source. The selection of the type of the pulverizer and the selection of manufacturers can be set according to the actual environment and the actual requirements in the specific implementation process. All the raw materials can be crushed, and the components of the crushed materials are consistent with those of the finished products obtained in the above embodiments after being filtered and sieved, and the method belongs to the protection scope of the invention.

Example 2:

a preparation method of a composition for relieving alcoholism and protecting liver comprises the steps of selecting 9 g of Chinese olive, 9 g of sharpleaf galangal fruit, 10 g of finger citron, 10 g of bunge cherry seed, 15 g of kudzuvine root and 15 g of hovenia dulcis thunb according to corresponding proportions, mixing, frying for 3 minutes at 130 ℃ in an iron pan, sieving by a 100-mesh sieve after coarse crushing, adding 9 g of lophatherum gracile, 10 g of orange peel, 10 g of purple perilla and 970 g of water for decocting, decocting for 40 minutes at 100 ℃, and filtering residues to obtain a finished product.

Example 3:

a preparation method of a composition for relieving alcoholism and protecting liver comprises the steps of selecting 5g of Chinese olive, 4 g of sharpleaf galangal fruit, 5g of finger citron, 5g of bunge cherry seed, 10 g of kudzuvine root and 10 g of hovenia dulcis thunb according to corresponding proportions, mixing, frying for 10 minutes at 110 ℃ in an iron pan, sieving by a 80-mesh sieve after coarse crushing, adding 6.5 g of lophatherum gracile, 5g of orange peel, 7 g of perilla and 862.5 g of water, decocting for 85 minutes at 90 ℃, and filtering residues to obtain a finished product.

Example 4:

a preparation method of a composition for relieving alcoholism and protecting liver comprises the steps of selecting 8 g of Chinese olive, 8 g of sharpleaf galangal fruit, 8 g of finger citron, 8 g of bunge cherry seed, 14 g of kudzuvine root and 14 g of hovenia dulcis thunb according to corresponding proportions, mixing, frying for 3 minutes at 130 ℃ in an iron pan, sieving by a 100-mesh sieve after coarse crushing, adding 8.5 g of lophatherum gracile, 8 g of orange peel, 9 g of perilla and 855 g of water for decoction, decocting for 40 minutes at 100 ℃, and filtering residues to obtain a finished product.

Example 5:

a preparation method of a composition for relieving alcoholism and protecting liver comprises the steps of selecting 7 g of Chinese olive, 5g of sharpleaf galangal fruit, 6 g of fingered citron, 6 g of bunge cherry seed, 12 g of kudzuvine root and 12 g of hovenia dulcis thunb according to corresponding proportions, mixing, frying for 3 minutes at 130 ℃ in an iron pan, sieving by a 100-mesh sieve after coarse crushing, adding 8 g of lophatherum gracile, 6 g of orange peel, 8 g of purple perilla and 1050 g of water for decoction, decocting for 40 minutes at 100 ℃, and filtering residues to obtain a finished product.

The administration mode is as follows: the oral liquid preparation is 25mL per bottle, and the dosage per time is not more than 75 mL.

The present invention is not limited to the above alternative embodiments, and any other products in various forms can be obtained by the present invention, and the present invention is within the protection scope of the present invention. The above embodiments should not be construed as limiting the scope of the present invention, and it will be understood by those skilled in the art that modifications may be made to the technical solutions described in the above embodiments, or equivalent substitutions may be made to some or all of the technical features thereof, without departing from the scope of the present invention, and at the same time, such modifications or substitutions may not make the essence of the corresponding technical solutions depart from the scope of the embodiments of the present invention.

Claims

1. The composition for relieving alcoholism and protecting liver is characterized by being prepared from the following raw materials in parts by mass:

2. The composition for relieving alcoholism and protecting liver according to claim 1, wherein the composition is prepared from the following raw materials in parts by mass:

3. The composition for relieving alcoholism and protecting liver according to claim 2, wherein the composition is prepared from the following raw materials in parts by mass:

4. A method for preparing the composition for alleviating hangover and protecting liver as claimed in any one of claims 1 to 3, which comprises selecting and mixing the olive, the alpinia oxyphylla, the fingered citron, the bunge cherry seed, the kudzuvine root and the hovenia dulcis thunb according to the corresponding proportion, frying in an iron pan, crushing coarsely, adding the lophatherum gracile, the orange peel, the perilla frutescens and the solvent for decoction, and filtering the residue to obtain the finished product.

5. The method for preparing a composition for alleviating hangover and protecting liver as claimed in claim 4, wherein the frying temperature is 110 ℃ and 130 ℃ when frying in an iron pan;

the frying time is 3-10 minutes.

6. The method for preparing the composition for relieving or neutralizing the effect of alcohol and protecting the liver according to claim 5, wherein the particle size of the coarsely crushed composition is 80-100 meshes.

7. The preparation method of the composition for relieving alcoholism and protecting liver as claimed in claim 4, wherein the solvent is water.

8. The preparation method of the composition for relieving alcoholism and protecting liver according to claim 4, wherein the mass ratio of the total mass of the Chinese olive, the fructus alpiniae oxyphyllae, the finger citron, the bunge cherry seed, the root of kudzu vine, the hovenia dulcis, the lophatherum gracile, the orange peel and the perilla to the solvent is 1: 10-15.

9. The preparation method of the composition for relieving alcoholism and protecting liver as claimed in claim 4, wherein the decocting temperature is 90-100 ℃;

the decoction time is 40-85 minutes.

10. The preparation method of the composition for relieving alcoholism and protecting liver as claimed in claim 4, wherein the finished product is an oral preparation.