CN103182024A - Medicine for treating wind-heat type common cold and preparation method thereof - Google Patents
Medicine for treating wind-heat type common cold and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a medicine for treating wind-heat type common cold. The medicine is prepared from the following ingredients by weight: 33.1-38.2 parts of gypsum, 8.6-10.6 parts of honeysuckle, 9.1-10.0 parts of scutellaria baicalensis, 4.9-6.6 parts of rehmannia, 4.0-5.7 parts of fructus forsythiae, 4.2-5.4 parts of jasmine, 4.0-5.7 parts of herba violae, 7.1-8.1 parts of radix scrophulariae, 4.0-5.7 parts of radix gentianae, 4.2-5.4 parts of radix isatidis, 3.3-4.4 parts of rhizome anemarrhenae and 3.5-4.2 parts of radix ophiopogonis. The medicine is simple and reasonable in composition, and has the functions of clearing away heat and toxic materials, dispelling wind and relieving exterior syndrome, cooling blood and promoting eruption, nourishing yin and moisturizing lung, and cooling down to relieve restlessness. The invention further discloses a preparation method of the medicine, which comprises the following steps: taking the gypsum with the weight part to prepare gypsum extracting solution, and concentrating the solution, drying the rest of ingredients according to the mass percent, and crushing the ingredients into coarse powder of 250-850um or 10-50mesh, mixing uniformly, placing the mixture into a supersonic extractor, adding 70% ethanol to extract so as to obtain the intermediate extracting liquid with effective components, placing the intermediate extracting liquid with effective components still for 48-72h, taking and filtering supernatant, recycling ethanol, and mixing the filtered solution with the gypsum concentrate to obtain the concentrated extract with effective components.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, what relate generally to is a kind of medicine for the treatment of anemopyretic cold and preparation method thereof.
Background technology
Flu is the upper respiratory tract infection that is caused by multiple virus, is commonly called as " cold ", is equal generable common actute infection respiratory tract diseases of the four seasons, and self-healing property is arranged.Flu is divided into common cold and influenza clinically again.Many with following one or more symptoms during morbidity, as part and General Symptomies such as nasal obstruction, watery nasal discharge, sneeze, cough, pharyngeal discomfort and fear of cold, low grade fever, the general course of disease did not wait in 5 to 10 days; If occur together lower respiratory infection, the course of disease can extend to 7 to 15 days.
It is sporadic that the common cold case distributes, do not cause popular, the normal bacterial infection that easily merges.Winter-spring season is seen at most, can betide any age, and is the highest with children's's sickness rate, often is sporadic.Influenza is the acute respiratory infectious disease that is caused by influenza virus, and its infectiousness is big, and the easy variation of this virus easily causes and breaks out and be very popular.
Acute upper respiratory tract infection has 70%-80% to be caused by virus approximately, mainly contains influenza virus (first, second, third), parainfluenza virus, respiratory syncytial virus, adenovirus, rhinovirus, echovirus, Coxsackie virus, Measles virus, rubella virus.Bacterial infection can directly or after viral infection take place, and for seeing, is hemophilus influenza, streptococcus pneumoniae and staphylococcus etc. with Hemolytic streptococcus secondly more; Accidental gram negative bacilli.Its infection mainly show as rhinitis, pharyngolaryngitis or tonsillitis.As risk factors such as suffering from cold, drench with rain, be overtired, when whole body or respiratory tract local defense function were reduced, former virus or the antibacterial that has been present in upper respiratory tract or has invaded from the external world can breed rapidly, causes morbidity.
Doctor trained in Western medicine is divided into 5 kinds of different types according to the difference of the cause of disease, clinical manifestation with flu: common cold, viral pharyngitis, laryngitis and bronchitis, herpangina, pharyngoconjunctival fever, bacterial pharyngotonsillitis.Western medical treatment adopt comprise lie up, general treatment such as polydipsia water, and symptomatic treatment: high hot irritated person can give analgesic tranquilizer, and laryngopharyngitis is obvious, or dry cough is when heavier, atomization inspiration treatment etc.; For merging comparatively serious bacterial infection person, give antibacterials and antiviral therapy, but Respirovirus still there is not the specially good effect antiviral drugs at present.
Adopt the principle treatment upper respiratory tract infection curative effect of tcm treatment according to syndrome differentiation original.The traditional Chinese medical science is divided into four types of wind-chill cold, common cold due to wind heat, summer-wet type common cold and influenzas (influenza) according to the principle of determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs with flu.For common cold due to wind heat, disease sees that the heavy aversion to cold of heating is light, and headache has antiperspirant, and is thirsty, dry pharynx and pain, and cough, it is yellow thick to cough up phlegm, oliguria with reddish urine, yellow and thin fur, the floating and rapid pulse person controls the method that expels the heat-evil with relieving the exterior syndrome with drugs of pungent in flavor and cool in nature, lung qi dispersing; Stick up detoxifying pills etc. as SUNJU GANMAO PIAN or antitoxic bolus of honeysuckle flower and forsythia, tablet of antelope horn for common cold, antelope.
In the medicine of numerous kinds for the treatment of flu, because Chinese patent medicine has little, the eutherapeutic characteristics of side effect, so welcome by numerous medical workers and patient.
Summary of the invention
One of purpose of the present invention is to provide a kind of Chinese patent medicine for the treatment of common cold due to wind heat, and this medicine prescription is concisely reasonable, has heat-clearing and toxic substances removing, dispelling wind to relieve the exterior syndrome, removing heat from blood rash, nourishing YIN and moistening the lung, the effect of analgesic relieving restlessness.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese patent medicine of common cold due to wind heat.
The invention is for realizing one of goal of the invention, by the following technical solutions:
The Chinese patent medicine for the treatment of common cold due to wind heat of the present invention, made by following each component by weight:
Gypsum Fibrosum 33.1-38.2, Flos Lonicerae 8.6-10.6, Radix Scutellariae 9.1-10.0, Radix Rehmanniae 4.9-6.6, Fructus Forsythiae 4.0-5.7, Fructus Gardeniae 4.2-5.4, Herba Violae 4.0-5.7, Radix Scrophulariae 7.1-8.1, Radix Gentianae 4.0-5.7, Radix Isatidis 4.2-5.4, Rhizoma Anemarrhenae 3.3-4.4, Radix Ophiopogonis 3.5-4.2.
Further, each component by weight is preferably:
Gypsum Fibrosum 34.2-37.2, Flos Lonicerae 9.1-10.1, Radix Scutellariae 9.4-9.8, Radix Rehmanniae 5.3-6.2, Fructus Forsythiae 4.4-5.2, Fructus Gardeniae 4.5-5.1, Herba Violae 4.4-5.2, Radix Scrophulariae 7.4-7.9, Radix Gentianae 4.4-5.2, Radix Isatidis 4.5-5.1, Rhizoma Anemarrhenae 3.6-4.2, Radix Ophiopogonis 3.7-4.0.
Further, each component by weight is more preferably:
Gypsum Fibrosum 35.3-36.3, Flos Lonicerae 9.3-9.8, Radix Scutellariae 9.4-9.7, Radix Rehmanniae 5.6-5.9, Fructus Forsythiae 4.6-5.0, Fructus Gardeniae 4.7-4.9, Herba Violae 4.6-5.0, Radix Scrophulariae 7.6-7.8, Radix Gentianae 4.6-5.0, Radix Isatidis 4.7-4.9, Rhizoma Anemarrhenae 3.8-4.0, Radix Ophiopogonis 3.8-3.9.
The preparation method of the Chinese patent medicine of the treatment common cold due to wind heat of the invention:
Get the Gypsum Fibrosum of above-mentioned weight portion, the step of preparation Gypsum Fibrosum extracting solution simmer down to Gypsum Fibrosum concentrated solution; To remain each components in mass portion, dry, make the step of coarse powder 250-850um or 24 orders-65 order, mixing; Each component of residue of mixing is put into the supersound extraction device, add 70% ethanol extraction, obtain the step of the middle extracting solution of effective ingredient; Extracting solution in the middle of the effective ingredient was left standstill 48-72 hour, incline and get supernatant, filter, reclaim ethanol, mix the step that obtains the effective ingredient concentrated extract with the Gypsum Fibrosum concentrated solution.
Further, when extracting solution prepares in the middle of the effective ingredient, comprise the adding 70% soak with ethanol 30-60 that each component total weight parts 5-7 doubly measures except Gypsum Fibrosum minute, continue adding 70% ethanol and doubly measure to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the step of the middle extracting solution one of effective ingredient.
Further, when extracting solution prepares in the middle of the effective ingredient, also comprise adding 70% ethanol that each component total weight parts 5-7 doubly measures except Gypsum Fibrosum again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the step of the middle extracting solution two of effective ingredient.
Further, when the Gypsum Fibrosum concentrated solution prepares, be included in the extraction equipment and add the purified water that 8-10 doubly measures the Gypsum Fibrosum weight portion and decocted 1.0-1.5 hour, collect the step of Gypsum Fibrosum extracting solution one.
Further, when the Gypsum Fibrosum concentrated solution prepares, also be included in the extraction equipment and add the purified water that 4-6 doubly measures the Gypsum Fibrosum weight portion and decocted 0.5-1.0 hour, collect the step of Gypsum Fibrosum extracting solution two.
Further, also comprise the step of the effective ingredient concentrated extract being made oral liquid, pill, tablet, granule dosage form.
The characteristic of each component of making medicine of the present invention is as follows:
Gypsum Fibrosum: effect expelling pathogenic factors from muscles for clearing heat, relieving restlessness quench the thirst, heat-clearing and toxic substances removing, pathogenic fire purging.Cure mainly the calentura high fever and do not move back, vexed coma, delirium is gone mad, thirsty and dry pharynx, the lung-heat dyspnea with rapid respiration, the heatstroke spontaneous perspiration, stomach-fire headache, toothache, hyperactivity of toxic heat is sent out the speckle dermexanthesis, aphtha of the mouth and tongue.Forge deposited promoting tissue regeneration and ulcer healing.The external treatment ulcer sores is burst and is not closed up the burning hot wound of soup.The main hydrous calcium sulfate (CaSO42H2O) that contains.Pharmacological action antipyretic and anti-inflammatory, sedation and analgesia.
Flos Lonicerae: sweet, cold, hot, fragrant; Heat-clearing and toxic substances removing, wind-heat dissipating.Contain compositions such as cyclohexanhexanol, flavonoid, inositol, Saponin and tannin, comprise chlorogenic acid, isochlorogenic acid, luteolin etc. and based on the volatile oil of the pure and mild linalool of Flos Lonicerae.Flos Lonicerae all has stronger inhibitory action to various pathogens such as staphylococcus aureus, dysentery bacteriums, multiple pathogenic microorganisms such as leptospira, influenza virus and pathogenic moulds also there is inhibitory action, also has effects such as tangible antiinflammatory and refrigeration function and excited maincenter, enhancing immune function.Be usually used in the carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease heating.
Radix Scrophulariae: sweet in the mouth, hardship, salty; Return lung, stomach, kidney channel.The function clearing away heat and cooling blood, detoxifcation YIN nourishing, eliminating stagnation sore-throat relieving.The main compositions such as alkaloid, saccharide, sterol, aminoacid, fatty acid, volatile oil, carotene and retinoid that contain.Have antibiotic, blood sugar lowering, calmness, blood pressure lowering, heart tonifying, blood vessel dilating effect.The maculae caused by violent heat pathogen that are used for, constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion scrofula, carbuncle sore tumefacting virus are hindered in consumption of YIN caused by febrile disease, pharyngalgia excessive thirst, Tianjin more.
Radix Rehmanniae: sweet, cold; GUIXIN, liver, kidney, clearing away heat and cooling blood, yin nourishing is promoted the production of body fluid.Chemical constituent wherein again based on iridoid glycosides (content of catalpol is the highest), also contains saccharide, several amino acids, inorganic elements and other organic principles etc. based on glycoside.Have effects such as blood sugar lowering, hemostasis, anticoagulation, anti inflammatory immunity, anti-hepatic injury, be used for calentura crimson tongue excessive thirst more, yin asthenia generating intrinsic heat, the hectic fever due to YIN-deficiency consumptive fever, is quenched one's thirst at interior-heat, spits blood, and epistaxis is sent out the speckle dermexanthesis.
Fructus Forsythiae: bitter in the mouth, be slightly cold; Return lung, the heart, small intestine meridian.Heat-clearing and toxic substances removing, dispersing swelling and dissipating binds.Be used for carbuncle, scrofula, acute mastitis, erysipelas, anemopyretic cold, epidemic febrile disease is from the beginning of, warm joining the army, high hot excessive thirst, coma is sent out speckle, the pyretic stranguria urine retention.Chemical constituent has forsythol, Fructus Forsythiae phenols, oleanolic acid, betulic acid, ursolic acid, pinoresinol, sterol compound, still contains multiple hydro carbons, aldoketones, alcohol ester ethers volatile ingredient.That pharmacological action has is antibiotic, pharmacological action such as is told, protects the liver at by antiinflammatory, heart tonifying, analgesic, diuresis, town.
Fructus Gardeniae: bitter, cold; GUIXIN, liver, lung, stomach warp.Pathogenic fire purging relieving restlessness, clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body.Be used for that calentura is vexed, liver-fire conjunctival congestion, headache, jaundice due to damp-heat, stranguria, dysentery hematuria, aphtha of the mouth and tongue, sore swollen toxin, sprain and swell and ache.Contain flavonoid gardenin, triterpenoid compound crocin etc.; Also contain iridoid glycosides gardenoside, gardenoside etc. in addition, still contain D-mannitol, cupreol, nonacosane, ursolic acid.Function of gallbladder promoting is arranged, the effect that improves body resistance against diseases, the function of improving liver and gastronintestinal system and alleviate pancreatitis, calmness, resisting pathogenic microbes, reduction myocardial contraction, blood pressure lowering, anastalsis, diarrhea inducing, analgesia, antiinflammatory and treatment soft tissue injury is arranged.
Herba Violae: bitter in the mouth, suffering, cold; GUIXIN, Liver Channel.Has heat-clearing and toxic substances removing, the effect of removing heat from blood detumescence.Cure mainly furuncle carbuncle, mumps, scrofula, erysipelas, acute mastitis, acute appendicitis, damp and hot and dysentery, jaundice, conjunctival congestion and swelling pain, sore throat, diseases such as traumatic injury, carbuncle, venom are controlled in external application.Chemical constituent has the esters of glycoside, flavonoid, wax, cerinic acid and unsaturated acids etc.Effects such as antibiotic, antiviral, antiendotoxin, detumescence, antiinflammatory are arranged.
Radix Scutellariae: nature and flavor hardship, cold; Return warps such as lung, gallbladder, spleen, stomach.Heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.Be used for hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, the cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.Main effective ingredient is flavone compound.Anti-bacteria and anti-virus, antiinflammatory antiallergic action arranged, regulate immunologic function, analgesic, calm, blood pressure lowering blood fat reducing, anticoagulant and antiplatelet aggregation, protect the liver, function of gallbladder promoting, antioxidation etc.
Radix Gentianae: bitter in the mouth is cold in nature, returns liver, gallbladder, urinary bladder channel.Be used for dampness-heat in the liver and gallbladder, dizziness and red eyes, Hiccough and deaf, the ear pain that swells, hypochondriac pain bitter taste, the puckery pain of dark coloured urine, damp-heat vaginal discharge.Feeling of fullness in the head headache, conjunctival congestion and swelling pain, the deaf ear that is used for jaundice due to damp-heat, urine leaching pain, swelling of the vulva pudendal pruritus, damp-heat vaginal discharge, liver and gall excess-fire swells, hypochondriac pain bitter taste, calentura, convulsion with spasms.Root contains secoiridoid glycosides bitter principle gentiopicrin, swertiamarin etc.Resisting pathogenic microbes, antiinflammatory, analgesic, analgesia, calmness, stomach invigorating arranged, protect the liver, effect such as function of gallbladder promoting, blood pressure lowering, blood sugar lowering, enhancing immunity.The liver heat removing gallbladder, dampness removing heat.
Radix Isatidis: bitter in the mouth, cold in nature; GUIXIN, stomach, liver, gallbladder meridian.The function heat-clearing and toxic substances removing, the removing heat from blood sore-throat relieving.Cure mainly the disease due to the warm poison, send out speckle etc. as influenza, upper respiratory tract infection, epidemic encephalitis, parotitis, acute enteritis, bacillary dysentery, hepatitis, facial erysipelas, calentura.Main component has indigo glycoside, isatin, indigo, Isatan B, uridnine, uracil, hypoxanthine etc., also contain vegetable protein, resin-like thing, saccharide, sinigrin, several amino acids and trace element, still contain the compositions such as antibacterial substance of anti-Grain-positive and negative bacteria.Have effects such as antibiotic, antiviral, anti-leptospira, antitumor, detoxifcation, enhancing immunologic function.
The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold; Return lung, stomach, kidney channel.The function clearing away heat-fire promotes the production of body fluid and moisturizes.Be used for fever caused by exogenous pathogenic factors, high hot excessive thirst, lung-heat type cough, osteopyrexia and fever, interior-heat is quenched one's thirst, the dryness of the intestine constipation.Main component has zhimusaponin (6 kinds), flavonoid (Mengiferin, isomangiferin etc.), alkaloids, organic acid, anemaran, multiple metallic element and lymphatic temperament, reducing sugar etc.Have resisting pathogenic microbes, suppress Na(+), K(+)-atpase activity, the sympathetic-adrenal gland's function of influence, effects such as hypoglycemic activity, refrigeration function, antitumor.
Radix Ophiopogonis: sweet in the mouth, little hardship; Cool in nature; GUIXIN, lung, stomach warp.Nourishing YIN and moistening the lung, reinforcing stomach reg fluid, relieving restlessness clears away heart-fire.Be used for diseases such as consumption of body fluid caused by febrile disease, restlessness and thirst, dry pharynx lung-heat, constipation with dry stool.Chemical constituent has and contains multiple steroid saponin, flavone compound, cupreol, aminoacid, volume glucose and 28 kinds of inorganic elementss of glycoside.Can improve immunologic function; Various bacteria there is inhibitory action; Can strengthen the pituitary adrenal system function, improve the organism adaptation ability; Arrhythmia and the peripheral vascular effect of expansion are arranged; Can improve hypoxia-bearing capability; Hypoglycemic activity is arranged.
This side forms, and is scientific and reasonable.Gypsum Fibrosum is sweet in flavor and cold in property in the side, clearing away heat-fire, and relieving restlessness is quenched the thirst, and brings down a fever to reach table, the kind edema caused by disorder of QI pathogenic heat of separating; The Flos Lonicerae heat-clearing and toxic substances removing, the clear purte the white of Radix Scutellariae is monarch drug altogether; Fructus Forsythiae, Fructus Gardeniae are detoxified diathermanous, are ministerial drug altogether; Radix Isatidis, Radix Gentianae clearing away heat and cooling blood, resolving toxin and disinhibiting the throat, the Herba Violae removing pathogenic heat from blood and toxic substance from the body, clearing heat for detumescence, the Radix Rehmanniae, Radix Scrophulariae clearing away heat and cooling blood, the detoxifcation yin nourishing, the Rhizoma Anemarrhenae, Radix Ophiopogonis nourishing YIN and moistening the lung, analgesic relieving restlessness is all assistant and makes.All medicines share, and play heat-clearing and toxic substances removing altogether, dispelling wind to relieve the exterior syndrome, removing heat from blood rash, nourishing YIN and moistening the lung, the merit of analgesic relieving restlessness.
The ultrasonic extraction that adopts in the preparation method of the present invention is special roles such as the accelerated particle motion that utilizes ultrasound wave to produce, cavitation effect, vibration homogenize, be used for the extraction of material effective ingredient, the new extractive technique that ingredient is extracted quickly and efficiently.
Adopt this extractive technique to prepare medicine of the present invention, obvious with the traditional handicraft comparative advantages:
1, extraction efficiency height: the unique physical characteristic of ultrasound wave can be impelled plant cell tissue's breaking cellular wall or distortion, makes the Chinese medicine extracts active ingredients more abundant, and extraction ratio significantly improves than traditional handicraft and reaches 50-500%.
2, extraction time is short: the intensified by ultrasonic wave Chinese medicine extraction can obtain the optimum extraction rate at 24-40 minute usually, and extraction time shortens more than 2/3 than traditional method, and medical material raw material treating capacity is big.
3, the extraction temperature is low: the optimum temperature of supersound extraction Chinese crude drug has protective effect at 40-60 ℃ to effective ingredient in the medical material of case of thermal instability, facile hydrolysis or oxidation, and is simultaneously energy-saving and cost-reducing greatly.
4, wide adaptability: the supersound extraction Chinese crude drug is not subjected to the restriction of compositional polarity, molecular weight size, is applicable to the extraction of most kind Chinese crude drugs and each constituents, and is applicable to multiple solvent.
5, extraction medicinal liquid impurity is few, and effective ingredient is easy to separate, purification.
6, extraction process operating cost is low, and overall economic efficiency is remarkable.
7, operation is simple, plant maintenance, easy maintenance.
Pharmacological research:
Pharmacological research has confirmed that medicine of the present invention has following pharmacological action at present:
1, bacteriostasis: (plate punch method extracorporeal bacteria inhibitor test sees Table 1)
The external fungistatic effect laboratory test results of table 1 the present invention: (pharmacological evaluation)
Show with the external inhibition zone result of the test (table 1) of plate punch method experimental observation medicine of the present invention to 7 kinds of pathogenic bacterium: medicine of the present invention and main component Fructus Forsythiae, Radix Scutellariae etc. have the obvious suppression effect to common antibacterial.Especially stronger to the effect of upper respiratory tract infection common bacteria, but adopt the finished product of traditional aqueous extraction-alcohol precipitation technology poor slightly not as medicine of the present invention (supersound extraction) bacteriostasis.
2, refrigeration function: get this product by 10ml/kg perfusion fever model rat, observe the rat sign.
The result shows: experimental rat body temperature descends obviously, shows that this product has the better solutions heat effect.
3, acute toxicity test: adopt medicine condensed water decoct of the present invention (1:4) to gavage mice, by every day 2 times, each 30ml/kg.The mice activity has decline slightly after the administration.4hr after the drug withdrawal, transference cure.The back is observed after gavaging 7 continuously.
The result shows: experiment mice is strong depositing all, and untoward reaction is not seen in the no abnormal variation of conscience spleen lung kidney.
Clinical observation
Drug therapy common cold due to wind heat 300 examples of the present invention and contrast treatment 150 examples.
Data, method and discussion
1, physical data
1,1 case source: 300 examples, male's 150 examples wherein, women's 150 examples, 1-70 years old ages, the course of disease 3-10 days, average 6 days.
1,2 selections of falling ill
1,2,1 diagnostic criteria: formulate with reference to " traditional Chinese medical science common disease conventional treatment " (1998).
Diagnosis basis:
1,2,1,1 body temperature does not move back more than lasting a few hours more than 37 ℃, after body temperature descends, raises gradually again.
1,2,1,2 fevers with aversion to cold, shiver with cold, thirst and liking drink, red tongue with yellow fur, rapid pulse.
1,2,1,3 high fevers, cough or dyspnea with rapid and short breath, chest pain, thirsty.
1,2,2 include the case standard in: Western medicine diagnose is flu or influenza, and Chinese medical discrimination belongs to lung-heat disease person, and severity extent belongs to light, moderate person, 1-70 years old ages, male or female, the course of disease＜10 day.
1,2,3 get rid of the case standard:
1, the dialectical genus wind-cold type of 2,3,1 Chinese medicine, summer-wet type common cold.
1,2,3,2 gestation and newborn phase women, the psychotic.
1,2,3,3 merge to have the inclination, body, liver function and the serious primary disease person of hemopoietic system.
1,2,3,4 allergic constitutions or to multiple drug allergy person.
1,2,3,5 used other medicine person.
1,2,3,6 state of an illness severes, merge other disorders person.
2, Therapeutic Method:
Consumption: a 20ml～40ml, 3 times on the one.
Usage: oral.
The course for the treatment of: 6 days.
3, observation index:
3,1 curative effect determinate standard
3,1,1 recovery from illness: treat 3 days normal with interior temperature recovery, clinical symptoms, Signs disappear or basic disappearance.
3,1,2 produce effects: treat 3 days normal substantially with interior body temperature, clinical symptoms, Signs are obviously improved.
3,1,3 take a turn for the better: treated 3, body temperature does not descend, and clinical symptoms, Signs are obviously improved.
3,1,4 is invalid: treated 3, body temperature does not descend or raises, and clinical symptoms, Signs do not have improvement.
3,2 health giving quality observation indexs:
3,2,1 coughing and wheezing is eliminated and is alleviated no change
3,2,2 fevers with aversion to cold are eliminated and are alleviated no change
3, the thirsty elimination of 2,3 pharyngalgia alleviates no change
3,2, the 4 yellow thick eliminations of coughing up phlegm alleviate no change
4.1 clinical treatment curative effect: see Table 2.
Table 2 clinical treatment curative effect (%)
From clinical control therapeutic outcome (table 2) as can be seen, medicine of the present invention is 91.0% for the treatment total effective rate of common cold due to wind heat.Wherein, cure rate 56.0.0%, improvement rate 35.0%, inefficiency 9.0%, general curative effect is remarkable.
4.2 clinical control treatment curative effect: see Table 3.
Table 3 clinical control treatment (%)
From clinical control therapeutic outcome (table 3) as can be seen, contrast other treatment common cold due to wind heat medicine, curative effect of medication of the present invention is more remarkable.Wherein, the treatment group is taken medicine of the present invention, and matched group 1 is taken SUNJU GANMAO PIAN, and matched group 2 is taken antitoxic bolus of honeysuckle flower and forsythia.
4.3 untoward reaction: do not see obvious side reaction in the therapeutic process.
4.4 conclusion:
Clinical experiment shows that medicine of the present invention consumes the impairment of YIN branch for because of YIN-deficiency of the lung and kidney, pharyngeal mistake is supported, or the evil diseases such as the laryngopharynx swelling and pain that causes in pharynx, the hoarseness of crying out, thirsty expectorant Huang that stagnate, and especially the heating weight aversion to cold to the common cold due to wind heat due to hyperactivity of toxic heat is light, headache has antiperspirant, and is thirsty, dry pharynx and pain, cough, it is yellow thick to cough up phlegm; oliguria with reddish urine, yellow and thin fur, the treatment of diseases such as floating and rapid pulse; determined curative effect, treating both the principal and secondary aspects of a disease, no side effects and untoward reaction.By clinical observation, follow up a case by regular visits to feedback, add up to efficient and reach more than 90%.
The case case
1, patient's conscious nasal obstruction, watery nasal discharge before 3 days, the anti-cold medicine poor effect is obeyed in slight cough certainly, feels fear of cold in nearly 1 day, heating, sweating is not smooth, dizzy distending pain, 37.7 ℃ of body temperature are satisfied and are come the court to go to a doctor.Check: the patient is refreshing clear, looks into the bottleneck throat redness, tonsil (-); Two pulmonary respiration sounds are clear, and cardiac auscultation is no abnormal, and the abdomen inspection is no abnormal.Hemogram WBC is normal, and L is high slightly.Surplus (-).
Diagnosis: flu.
Treatment: oral drug mixture of the present invention: 30ml/tid/ every day.
Two examine (on May 15th, 2010)
2, patient: Jiang, man, 32 years old.First visit (on August 2nd, 2011)
Patient's readme: conscious nasal obstruction, watery nasal discharge a few days ago, slight cough, cough, sometimes hot and sometimes cold, xerostomia is had sore throat, and is off one's feed.Dizzy distending pain, 38.2 ℃ of body temperature.Check: the patient is refreshing clear, looks into the bottleneck throat redness, tonsil (+); Two pulmonary respiration sounds are clear, and cardiac auscultation is no abnormal, and the abdomen inspection is no abnormal.Hemogram WBC is high slightly, and L is high slightly.Surplus (-).
Diagnosis: flu.
Treatment: oral drug mixture of the present invention: 40ml/tid/ every day.
Two examine (on August 5th, 2011)
All symptom complete obiterations of patient.
3, patient: Cai, woman, 6 years old.First visit (on October 17th, 2009)
Heating, micro evil wind, sweating is not smooth, dizzy distending pain, how red complexion is, and the red order of order expands, the little thist with desire to drink of xerostomia, cough, the thick Huang of expectorant is coughed up and is told not wellly, and it is mute to cough loud, high-pitched sound, dry pharynx, congestion and swelling pain, nasal obstruction, stream turbid nasal discharge, the little Huang of tongue fur, floating and rapid pulse, 38.2 ℃ of body temperature.Check: the patient is refreshing clear, looks into the bottleneck throat redness, tonsil (+); Two pulmonary respiration sounds are clear, and cardiac auscultation is no abnormal, and the abdomen inspection is no abnormal.Hemogram WBC is high slightly, and L is high slightly.Surplus (-).
Treatment: oral drug mixture of the present invention: 15ml/tid/ every day.
Two examine (on October 20th, 2009)
All symptom complete obiterations of patient.
Description of drawings
Fig. 1 is the invention pharmaceutical preparation schematic flow sheet;
The specific embodiment
Embodiment one
In the present embodiment, the medicine for the treatment of common cold due to wind heat is made by the each component of following weight portion:
Gypsum Fibrosum 36.3, Flos Lonicerae 9.3, Radix Scutellariae 9.7, Radix Rehmanniae 5.6, Fructus Forsythiae 4.6, Fructus Gardeniae 4.9, Herba Violae 4.6, Radix Scrophulariae 7.8, Radix Gentianae 4.6, Radix Isatidis 4.9, the Rhizoma Anemarrhenae 3.8, Radix Ophiopogonis 3.9.
Embodiment two
In the present embodiment, the medicine for the treatment of common cold due to wind heat is made by the each component of following weight portion:
Gypsum Fibrosum 35.3, Flos Lonicerae 9.8, Radix Scutellariae 9.4, Radix Rehmanniae 5.9, Fructus Forsythiae 5.0, Fructus Gardeniae 4.7, Herba Violae 5.0, Radix Scrophulariae 7.6, Radix Gentianae 5.0, Radix Isatidis 4.7, the Rhizoma Anemarrhenae 4.0, Radix Ophiopogonis 3.8.
Embodiment three
In the present embodiment, the medicine for the treatment of common cold due to wind heat is made by the each component of following weight portion:
Gypsum Fibrosum 50.0, Flos Lonicerae 13.4, Radix Scutellariae 13.4, Radix Rehmanniae 8.0, Fructus Forsythiae 3.7, Fructus Gardeniae 6.7, Herba Violae 6.7, Radix Scrophulariae 10.7, Radix Gentianae 3.7, Radix Isatidis 6.7, the Rhizoma Anemarrhenae 5.4, Radix Ophiopogonis 5.4.
Above-described embodiment 1-3 in conjunction with Fig. 1, is example with preparation mixture dosage form, and preparation method is:
Get Gypsum Fibrosum by the prescription mass parts, put into multi-functional extractor through pre-treatment, in multi-functional extractor, add the purified water that 8-10 doubly measures the Gypsum Fibrosum weight portion, decocted 1.0-1.5 hour, collect Gypsum Fibrosum extracting solution one; Add 4-6 again and doubly measure the purified water of Gypsum Fibrosum weight portion, decocted 0.5-1.0 hour, collect Gypsum Fibrosum extracting solution two; Merge the Gypsum Fibrosum extracting solution twice, concentrate, make Gypsum Fibrosum concentrated solution (1:1), 2-8 ° of storage.With the oven dry of all the other components, make coarse powder 250-850um or 24 orders-65 order, mixing, put into the supersound extraction device, added 70% soak with ethanol 30-60 minute that above-mentioned component weight portion 5-7 doubly measures, continue adding 70% ethanol doubly measures to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the middle extracting solution one of effective ingredient; Add 70% ethanol that above-mentioned component weight portion 5-7 doubly measures again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the middle extracting solution two of effective ingredient; Merge extracted twice liquid, low temperature 2-8 ℃ storage was left standstill 48-72 hour, inclined and got supernatant, filtered, and reclaimed ethanol; Add the Gypsum Fibrosum extracting solution, make the effective ingredient concentrated extract.The purified water that adding≤3-4 doubly measures in the effective ingredient concentrated extract forms water precipitating liquid; Mixing left standstill 24-36 hour, inclined and got supernatant, filtered, and formed the water precipitating supernatant; The continuous purified water that adds is regulated pH value to 4.0-6.0 to nearly full dose, standardize solution, and fill namely gets the mixture finished product; Character is pitchy liquid, and color and luster is bright, and mouthfeel is limpid, bitter in the mouth.
Need at concrete treatment, also the effective ingredient concentrated extract can be made oral liquid or other solid dosage formss, as pill, tablet, granule etc., so that take and carry.
The preparation technology of medicine of the present invention is final definite through studying, put into practice demonstration for many years repeatedly.Take water to put forward the technology of Gypsum Fibrosum, 70% ethanol ultrasonic extraction Chinese crude drug; characteristics such as have the extraction efficiency height, the time is short, temperature is low (being beneficial to the protection of thermally labile effective ingredient), wide adaptability, impurity are few; and energy-conservation joint consumption, simple to operate, safety, equipment use, maintenance, easy maintenance.
Claims (9)
1. medicine for the treatment of anemopyretic cold is characterized in that: made by following each component by weight:
Gypsum Fibrosum 33.1-38.2, Flos Lonicerae 8.6-10.6, Radix Scutellariae 9.1-10.0, Radix Rehmanniae 4.9-6.6, Fructus Forsythiae 4.0-5.7, Fructus Gardeniae 4.2-5.4, Herba Violae 4.0-5.7, Radix Scrophulariae 7.1-8.1, Radix Gentianae 4.0-5.7, Radix Isatidis 4.2-5.4, Rhizoma Anemarrhenae 3.3-4.4, Radix Ophiopogonis 3.5-4.2.
2. the medicine for the treatment of anemopyretic cold according to claim 1, it is characterized in that: each component by weight is preferably:
Gypsum Fibrosum 34.2-37.2, Flos Lonicerae 9.1-10.1, Radix Scutellariae 9.4-9.8, Radix Rehmanniae 5.3-6.2, Fructus Forsythiae 4.4-5.2, Fructus Gardeniae 4.5-5.1, Herba Violae 4.4-5.2, Radix Scrophulariae 7.4-7.9, Radix Gentianae 4.4-5.2, Radix Isatidis 4.5-5.1, Rhizoma Anemarrhenae 3.6-4.2, Radix Ophiopogonis 3.7-4.0.
3. the medicine for the treatment of anemopyretic cold according to claim 1 is characterized in that: each component by weight more preferably:
Gypsum Fibrosum 35.3-36.3, Flos Lonicerae 9.3-9.8, Radix Scutellariae 9.4-9.7, Radix Rehmanniae 5.6-5.9, Fructus Forsythiae 4.6-5.0, Fructus Gardeniae 4.7-4.9, Herba Violae 4.6-5.0, Radix Scrophulariae 7.6-7.8, Radix Gentianae 4.6-5.0, Radix Isatidis 4.7-4.9, Rhizoma Anemarrhenae 3.8-4.0, Radix Ophiopogonis 3.8-3.9.
4. prepare the preparation method of the medicine of the described treatment anemopyretic cold of claim 1-3, it is characterized in that:
Get the Gypsum Fibrosum of above-mentioned weight portion, the step of preparation Gypsum Fibrosum extracting solution simmer down to Gypsum Fibrosum concentrated solution; To remain each components in mass portion, dry, make the step of coarse powder 250-850um or 10 orders-50 order, mixing; Each component of residue of mixing is put into the supersound extraction device, add 70% ethanol extraction, obtain the step of the middle extracting solution of effective ingredient; Extracting solution in the middle of the effective ingredient was left standstill 48-72 hour, incline and get supernatant, filter, reclaim ethanol, mix the step that obtains the effective ingredient concentrated extract with the Gypsum Fibrosum concentrated solution.
5. the preparation method of the medicine for the treatment of anemopyretic cold according to claim 4, it is characterized in that: when extracting solution prepares in the middle of the effective ingredient, comprise the adding 70% soak with ethanol 30-60 that each component total weight parts 5-7 doubly measures except Gypsum Fibrosum minute, continue adding 70% ethanol doubly measures to 8-10, extracted 1.0-1.5 hour down at 45-55 ℃, collect the step of the middle extracting solution one of effective ingredient.
6. the preparation method of the medicine for the treatment of anemopyretic cold according to claim 4, it is characterized in that: when extracting solution prepares in the middle of the effective ingredient, also comprise and add 70% ethanol that each component total weight parts 5-7 doubly measures except Gypsum Fibrosum again, extracted 0.5-1.0 hour down at 45-55 ℃, collect the step of the middle extracting solution two of effective ingredient.
7. the preparation method of the medicine for the treatment of anemopyretic cold according to claim 4, it is characterized in that: when the Gypsum Fibrosum concentrated solution prepares, be included in the extraction equipment and add the purified water that 8-10 doubly measures the Gypsum Fibrosum weight portion and decocted 1.0-1.5 hour, collect the step of Gypsum Fibrosum extracting solution one.
8. the preparation method of the medicine for the treatment of anemopyretic cold according to claim 4, it is characterized in that: when the Gypsum Fibrosum concentrated solution prepares, also be included in the extraction equipment and add the purified water that 4-6 doubly measures the Gypsum Fibrosum weight portion and decocted 0.5-1.0 hour, collect the step of Gypsum Fibrosum extracting solution two.
9. the preparation method of the medicine for the treatment of anemopyretic cold according to claim 4 is characterized in that: also comprise the step of the effective ingredient concentrated extract being made oral liquid, pill, tablet, granule dosage form.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041668A (en) * | 2014-07-01 | 2014-09-17 | 孙丽君 | Dog food capable of preventing canine distemper and preparation method thereof |
| CN105169012A (en) * | 2015-08-28 | 2015-12-23 | 徐州天意动物药业有限公司 | Antivirus traditional Chinese medicine composition for livestock and poultry, fermented traditional Chinese medicine and preparation method and application |
| CN106975020A (en) * | 2016-11-28 | 2017-07-25 | 李元英 | A kind of Chinese medicine preparation for treating flu |
| CN109846834A (en) * | 2018-12-19 | 2019-06-07 | 江西赣隆药业有限公司 | The granule for having effects that the preparation method of clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and being prepared by this method |
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| CN1077640A (en) * | 1993-01-01 | 1993-10-27 | 河南省医学科学研究所 | High-concentration antipyretic-detoxicant preparation and preparation method thereof |
| CN101628077A (en) * | 2009-08-20 | 2010-01-20 | 河南太龙药业股份有限公司 | Preparation method of concentrated type heat-clearing and detoxicating oral liquid |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1077640A (en) * | 1993-01-01 | 1993-10-27 | 河南省医学科学研究所 | High-concentration antipyretic-detoxicant preparation and preparation method thereof |
| CN101628077A (en) * | 2009-08-20 | 2010-01-20 | 河南太龙药业股份有限公司 | Preparation method of concentrated type heat-clearing and detoxicating oral liquid |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104041668A (en) * | 2014-07-01 | 2014-09-17 | 孙丽君 | Dog food capable of preventing canine distemper and preparation method thereof |
| CN105169012A (en) * | 2015-08-28 | 2015-12-23 | 徐州天意动物药业有限公司 | Antivirus traditional Chinese medicine composition for livestock and poultry, fermented traditional Chinese medicine and preparation method and application |
| CN106975020A (en) * | 2016-11-28 | 2017-07-25 | 李元英 | A kind of Chinese medicine preparation for treating flu |
| CN109846834A (en) * | 2018-12-19 | 2019-06-07 | 江西赣隆药业有限公司 | The granule for having effects that the preparation method of clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and being prepared by this method |
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Application publication date: 20130703 |