CN109846834A - The granule for having effects that the preparation method of clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and being prepared by this method - Google Patents
The granule for having effects that the preparation method of clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and being prepared by this method Download PDFInfo
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- CN109846834A CN109846834A CN201811556785.5A CN201811556785A CN109846834A CN 109846834 A CN109846834 A CN 109846834A CN 201811556785 A CN201811556785 A CN 201811556785A CN 109846834 A CN109846834 A CN 109846834A
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Abstract
The present invention relates to Chinese medicinal granule technical fields, disclose a kind of preparation method with clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and the granule prepared by this method.Method includes the following steps: (1) is by dry Manyflower Gueldenstaedtid Herb pulverizing medicinal materials；(2) powder obtained with hot-water soak step (1)；(3) it filters, obtained filter cake is mixed with ethanol water；(4) ultrasonic extraction 2-3 times；(5) it filters, filtrate decompression concentration；(6) concentrate is mixed with pharmaceutically acceptable auxiliary material；(7) it is freeze-dried, collects dried cream powder, crushed 80 meshes, be placed in mixing channel and mix；(8) gained Manyflower Gueldenstaedtid Herb cream powder is pelletized, whole grain.The Manyflower Gueldenstaedtid Herb granule active component content with higher prepared using method of the present invention, and particle size uniformity.
Description
Technical field
The present invention relates to Chinese medicinal granule technical fields, and in particular to one kind has effects that clearing heat and detoxicating and cool blood detumescence
Manyflower Gueldenstaedtid Herb granule preparation method and by this method prepare granule.
Background technique
Chinese medicinal granule is using traditional Chinese medicine medicine materical crude slice as raw material, by modern processing technique and pharmaceutical technology to medicinal material
Full ingredient the processing such as extract, separate, be concentrated, dry, pelletize and pack and obtain, without decocting, for be directly formulated with
The granule taken after mixing it with water.Chinese medicinal granule not only remained the effective component of the prepared slices of Chinese crude drugs, cures mainly and effect, but also had standard system
One, curative effect is stable, easy to carry and do not have the advantages of of medicine materical crude slice such as be easy to adjust, and is taken after mixing it with water, can be made with granule composition prescription
For the supplement of traditional Chinese herbal decoction and Chinese patent drug.
Manyflower Gueldenstaedtid Herb is pulse family Gueldenstaedtia verna platymiscium, and whole herb with root can be used as medicine, and main component includes daucosterol, cupreol
Deng there is the effect of clearing heat and detoxicating, cool blood detumescence, cure mainly carbuncle swells furunculosis, erysipelas, acute appendicitis, scrofula, venomous snake bite, jaundice, intestines
Inflammation, dysentery etc..However, there is presently no the reports about Manyflower Gueldenstaedtid Herb granule and its preparation process.
Summary of the invention
The purpose of the invention is to provide a kind of to have effects that clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule
Preparation method and by this method prepare granule.
Have effects that the clearing heat and detoxicating preparation method with the Manyflower Gueldenstaedtid Herb granule of cool blood detumescence the present invention provides a kind of,
Method includes the following steps:
(1) by dry Manyflower Gueldenstaedtid Herb pulverizing medicinal materials, obtaining granularity is 40-100 mesh powder；
(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume；
(3) it filters, obtained filter cake is mixed with the ethanol water of 15-20 times of volume of inventory；
(4) ultrasonic extraction 2-3 times；
(5) it filters, filtrate decompression is concentrated to the concentrate that relative density is 1.1-1.2；
(6) concentrate is mixed with pharmaceutically acceptable auxiliary material；
(7) it is freeze-dried, collects dried cream powder, crushed 80 meshes, be placed in mixing channel and mix；
(8) gained Manyflower Gueldenstaedtid Herb cream powder is pelletized, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain.
Preferably, the temperature of hot water is 40-60 DEG C, and the time of hot-water soak is 1-3 hours.
Preferably, for the ultrasonic frequency used during ultrasonic extraction for 50-125kHz, each extraction time is 30-60
Minute.
Preferably, the concentration of the ethanol water is 30-60 weight %.
Preferably, the auxiliary material is at least one of soluble starch, starch, lactose, sucrose and dextrin.
Preferably, the auxiliary material is the mixture of starch, lactose and dextrin.
Preferably, the weight ratio of starch, lactose and dextrin is 1:0.01-0.5:0.1-2.
The present invention also provides the Manyflower Gueldenstaedtid Herb granules prepared by the above method.
Preferably, the specification of the Manyflower Gueldenstaedtid Herb granule is equivalent to 5-15 grams of Manyflower Gueldenstaedtid Herb medicinal material for every 1-3 grams.
The beneficial effects of the present invention are:
(1) according to the method described in the present invention, can by Manyflower Gueldenstaedtid Herb medicinal material main active (such as daucosterol,
Cupreol) sufficiently extract, the active substances such as plant fiber can be effectively removed, improve drug stability, easily
It stores, is convenient to take.
(2) grain forming of the Manyflower Gueldenstaedtid Herb granule prepared according to the method described in the present invention is preferable, and particle size is equal
It is even.
(3) it is directly prepared using Manyflower Gueldenstaedtid Herb medicinal material as raw material in method of the present invention, it is easy to implement, it is easy to accomplish
Industrialization.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of Manyflower Gueldenstaedtid Herb granule of the present invention the following steps are included:
(1) by dry Manyflower Gueldenstaedtid Herb pulverizing medicinal materials, obtaining granularity is 40-100 mesh powder；
(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume；
(3) it filters, obtained filter cake is mixed with the ethanol water of 15-20 times of volume of inventory；
(4) ultrasonic extraction 2-3 times；
(5) it filters, filtrate decompression is concentrated to the concentrate that relative density is 1.1-1.2；
(6) concentrate is mixed with pharmaceutically acceptable auxiliary material；
(7) it is freeze-dried, collects dried cream powder, crushed 80 meshes, be placed in mixing channel and mix；
(8) gained Manyflower Gueldenstaedtid Herb cream powder is pelletized, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain.
In method of the present invention, it can adopt and Manyflower Gueldenstaedtid Herb medicinal material is dried with the conventional methods in the field, example
Such as, natural air drying, drying etc..
In method of the present invention, it is preferable that the temperature of hot water is 40-60 DEG C, and the time of hot-water soak is that 1-3 is small
When.
In method of the present invention, during hot-water soak, by volume, the inventory of hot water is Manyflower Gueldenstaedtid Herb medicine
2-5 times of material specifically, such as can be 2 times, 2.5 times, 3 times, 3.5 times, 4 times or 5 times.
In method of the present invention, by volume, the inventory of the ethanol water is the 15- of Manyflower Gueldenstaedtid Herb medicinal material
20 times, specifically, such as can be 15 times, 16 times, 17 times, 18 times, 19 times or 20 times.In method of the present invention, make
Manyflower Gueldenstaedtid Herb medicinal material feeds intake with the ethanol water according to such volume ratio, can sufficiently extract the Manyflower Gueldenstaedtid Herb medicine
Main active in material.
In the present invention, the concentration of the ethanol water can be 30-60 weight %, specifically, such as can be 30
Weight %, 35 weight %, 40 weight %, 45 weight %, 50 weight %, 55 weight % or 60 weight %.In the preferred case, institute
The concentration for stating ethanol water is 40-50 weight %.
In method of the present invention, it is preferable that the ultrasonic frequency used during ultrasonic extraction is 50-
125kHz, each extraction time are 30-60 minutes.In method of the present invention, make Manyflower Gueldenstaedtid Herb in the ethanol water
The time of middle ultrasonic extraction and frequency can sufficiently extract the main active in Manyflower Gueldenstaedtid Herb within above range, and
And active constituent can be prevented to be denaturalized, so that the Manyflower Gueldenstaedtid Herb granule of preparation has preferable drug effect.
In method of the present invention, the strainer filtering that can use this field routine is filtered twice.Specific
In embodiment, filtering strainer used twice may each be the stainless steel cloth that mesh size is 200 mesh.
In method of the present invention, it is preferable that the auxiliary material is soluble starch, starch, lactose, sucrose and dextrin
At least one of.It is further preferred that the auxiliary material is the mixing of starch, lactose and dextrin.When the auxiliary material is starch, cream
When the mixing of sugar and dextrin, the mixed weight ratio of three is preferably 1:0.01-0.5:0.1-2.
In method of the present invention, the feeding quantity of the auxiliary material makes the specification of Manyflower Gueldenstaedtid Herb granule be every 1-3
Gram it is equivalent to 5-15 grams of Manyflower Gueldenstaedtid Herb medicinal material.
In method of the present invention, the method for the granulation can be to make the Manyflower Gueldenstaedtid Herb cream powder sieving
Grain.
In method of the present invention, by making the particle obtained after granulation successively use 20 meshes and 50 mesh sieves,
The Manyflower Gueldenstaedtid Herb granule of particle size uniformity can be obtained.
The present invention also provides the Manyflower Gueldenstaedtid Herb granules prepared by the above method.
Preferably, the specification of the Manyflower Gueldenstaedtid Herb granule is equivalent to 5-15 grams of Manyflower Gueldenstaedtid Herb medicinal material for every 1-3 grams, specifically
Ground, every 1 gram of Manyflower Gueldenstaedtid Herb granule are equivalent to 5 grams of Manyflower Gueldenstaedtid Herb raw medicinal herbs, and every 2 grams of Manyflower Gueldenstaedtid Herb granules are equivalent to
10 grams of Manyflower Gueldenstaedtid Herb raw medicinal herbs, every 3 grams of Manyflower Gueldenstaedtid Herb granules are equivalent to 15 grams of Manyflower Gueldenstaedtid Herb raw medicinal herbs.
The present invention will be described in detail by way of examples below.
Embodiment 1
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 80 mesh, adds 3 times of inventory of (50 DEG C) of hot water immersions 2 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 18 times of inventory of ethanol water (concentration is 45 weight %)
Mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are extracted 45 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.15；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A1.
Embodiment 2
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 100 mesh, adds 4 times of inventory of (40 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 35 weights with 16 times of inventory of ethanol water
Measure %) mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are each to extract 45 minutes, with the stainless steel cloth of 200 mesh
Filtering, filtrate decompression are concentrated to the concentrate that relative density is 1.16；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A2.
Embodiment 3
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 50 mesh, adds 4 times of inventory of (60 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 17 times of inventory of ethanol water (concentration is 48 weight %)
Mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are extracted 45 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.12；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A3.
Embodiment 4
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 60 mesh, adds 2 times of inventory of (60 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 40 weights with 20 times of inventory of ethanol water
Measure %), ultrasonic extraction 2 times under the ultrasonic frequency of 125kHz are extracted 60 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.10；
(2) be added in concentrate 80g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A4.
Embodiment 5
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 80 mesh, adds 4 times of inventory of (50 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 35 weights with 18 times of inventory of ethanol water
Measure %), ultrasonic extraction 2 times under the ultrasonic frequency of 125kHz are extracted 60 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.12；
(2) be added in concentrate 80g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A5.
Embodiment 6
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 100 mesh, adds 4 times of inventory of (45 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 45 weights with 16 times of inventory of ethanol water
Measure %), ultrasonic extraction 2 times under the ultrasonic frequency of 125kHz are extracted 60 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.14；
(2) be added in concentrate 80g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A6.
Embodiment 7
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 100 mesh, adds 5 times of inventory of (40 DEG C) of hot water immersions 1 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 50 weights with 15 times of inventory of ethanol water
Measure %), ultrasonic extraction 3 times under the ultrasonic frequency of 50kHz are extracted 30 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.20；
(2) be added in concentrate 50g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A7.
Embodiment 8
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 80 mesh, adds 4 times of inventory of (50 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 38 weights with 18 times of inventory of ethanol water
Measure %), ultrasonic extraction 3 times under the ultrasonic frequency of 50kHz are extracted 30 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.18；
(2) be added in concentrate 50g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A8.
Embodiment 9
(1) the Manyflower Gueldenstaedtid Herb medicinal material for taking 1kg dry, is crushed to 50 mesh, adds 4 times of inventory of (60 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake, (concentration is 45 weights with 16 times of inventory of ethanol water
Measure %), ultrasonic extraction 3 times under the ultrasonic frequency of 50kHz are extracted 30 minutes, every time with the stainless steel cloth mistake of 200 mesh
Filter, filtrate decompression are concentrated to the concentrate that relative density is 1.16；
(2) be added in concentrate 50g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) Manyflower Gueldenstaedtid Herb cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb formula
Grain sample A9.
Embodiment 10
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that ethanol water in step (1)
Concentration is 20 weight %, so that Manyflower Gueldenstaedtid Herb granule sample A10 be made.
Embodiment 11
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that ethanol water in step (1)
Concentration is 70 weight %, so that Manyflower Gueldenstaedtid Herb granule sample A11 be made.
Comparative example 1
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that ethanol water in step (1)
Inventory is 10 times of Manyflower Gueldenstaedtid Herb medicinal material, so that Manyflower Gueldenstaedtid Herb granule sample D1 be made.
Comparative example 2
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that ethanol water in step (1)
Inventory is 25 times of Manyflower Gueldenstaedtid Herb medicinal material, so that Manyflower Gueldenstaedtid Herb granule sample D2 be made.
Comparative example 3
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that in step (1), directly by powder
Manyflower Gueldenstaedtid Herb medicinal material after broken is heated to 100 DEG C and decocts 3 hours, then filters, is concentrated, so that Manyflower Gueldenstaedtid Herb granule sample be made
D3。
Comparative example 4
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that not firm heat application water logging in step (1)
The step of bubble, so that Manyflower Gueldenstaedtid Herb granule sample D4 be made.
Comparative example 5
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that not firm Shih-chao's sound mentions in step (1)
The step of taking, so that Manyflower Gueldenstaedtid Herb granule sample D5 be made.
Comparative example 6
Manyflower Gueldenstaedtid Herb granule is prepared according to the method for embodiment 1, the difference is that the particle in step (3) after granulation
Without 20 meshes and 50 mesh sieves, so that Manyflower Gueldenstaedtid Herb granule sample D6 be made.
Test case
(1) daucosterol in the Manyflower Gueldenstaedtid Herb granule sample prepared to above-described embodiment and comparative example, cupreol
Content is detected, and detects the chromatographic column used as C18 chromatographic column.
(2) partial size of the Manyflower Gueldenstaedtid Herb granule sample of above-described embodiment and comparative example preparation is detected using particles distribution instrument
Distribution situation, and analytical calculation partial size is the granule number percentage U of the partial size within the scope of 0.25-0.35mm0.25-0.35。
As a result as shown in table 1 below.
Table 1
By the result of table 1 can be seen that using method of the present invention preparation Manyflower Gueldenstaedtid Herb granule have compared with
High active component content, and particle size uniformity.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (9)
1. a kind of preparation method with clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule, which is characterized in that packet
Include following steps:
(1) by dry Manyflower Gueldenstaedtid Herb pulverizing medicinal materials, obtaining granularity is 40-100 mesh powder；
(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume；
(3) it filters, obtained filter cake is mixed with the ethanol water of 15-20 times of volume of inventory；
(4) ultrasonic extraction 2-3 times；
(5) it filters, filtrate decompression is concentrated to the concentrate that relative density is 1.1-1.2；
(6) concentrate is mixed with pharmaceutically acceptable auxiliary material；
(7) it is freeze-dried, collects dried cream powder, crushed 80 meshes, be placed in mixing channel and mix；
(8) gained Manyflower Gueldenstaedtid Herb cream powder is pelletized, particle successively uses 20 meshes and 50 mesh sieves, obtains Manyflower Gueldenstaedtid Herb granule.
2. the time of hot-water soak is the method according to claim 1, wherein the temperature of hot water is 40-60 DEG C
1-3 hours.
3. the method according to claim 1, wherein the ultrasonic frequency used during ultrasonic extraction is 50-
125kHz, each extraction time are 30-60 minutes.
4. method described in any one of -3 according to claim 1, which is characterized in that the concentration of the ethanol water is
30-60 weight %.
5. the method according to claim 1, wherein the auxiliary material is soluble starch, starch, lactose, sucrose
At least one of with dextrin.
6. according to the method described in claim 5, it is characterized in that, the auxiliary material is the mixture of starch, lactose and dextrin.
7. according to the method described in claim 6, it is characterized in that, the weight ratio of starch, lactose and dextrin is 1:0.01-0.5:
0.1-2。
8. the Manyflower Gueldenstaedtid Herb granule of the preparation of the method as described in any one of claim 1-7.
9. Manyflower Gueldenstaedtid Herb granule according to claim 8, which is characterized in that the specification of the Manyflower Gueldenstaedtid Herb granule is
Every 1-3 grams is equivalent to 5-15 grams of Manyflower Gueldenstaedtid Herb medicinal material.
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| CN201811556785.5A CN109846834A (en) | 2018-12-19 | 2018-12-19 | The granule for having effects that the preparation method of clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and being prepared by this method |
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