CN109646406A - The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method - Google Patents
The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method Download PDFInfo
- Publication number
- CN109646406A CN109646406A CN201811541536.9A CN201811541536A CN109646406A CN 109646406 A CN109646406 A CN 109646406A CN 201811541536 A CN201811541536 A CN 201811541536A CN 109646406 A CN109646406 A CN 109646406A
- Authority
- CN
- China
- Prior art keywords
- river vehicle
- careless river
- granule
- careless
- vehicle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000008187 granular material Substances 0.000 title claims abstract description 58
- 238000000034 method Methods 0.000 title claims abstract description 50
- 238000002360 preparation method Methods 0.000 title claims abstract description 14
- 229940124584 antitussives Drugs 0.000 title claims abstract description 7
- 230000000694 effects Effects 0.000 title description 4
- 239000000463 material Substances 0.000 claims abstract description 37
- 238000002156 mixing Methods 0.000 claims abstract description 37
- 239000000843 powder Substances 0.000 claims abstract description 28
- 239000006071 cream Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 21
- 239000012141 concentrate Substances 0.000 claims abstract description 20
- XTLNYNMNUCLWEZ-UHFFFAOYSA-N ethanol;propan-2-one Chemical compound CCO.CC(C)=O XTLNYNMNUCLWEZ-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000001914 filtration Methods 0.000 claims abstract description 18
- 239000011259 mixed solution Substances 0.000 claims abstract description 17
- 239000002245 particle Substances 0.000 claims abstract description 17
- 238000002137 ultrasound extraction Methods 0.000 claims abstract description 14
- 230000006837 decompression Effects 0.000 claims abstract description 10
- 239000012065 filter cake Substances 0.000 claims abstract description 10
- 239000000706 filtrate Substances 0.000 claims abstract description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 24
- 229920002472 Starch Polymers 0.000 claims description 18
- 239000008107 starch Substances 0.000 claims description 18
- 235000019698 starch Nutrition 0.000 claims description 18
- 229920001353 Dextrin Polymers 0.000 claims description 15
- 239000004375 Dextrin Substances 0.000 claims description 15
- 235000019425 dextrin Nutrition 0.000 claims description 15
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 14
- 239000008101 lactose Substances 0.000 claims description 14
- 244000025254 Cannabis sativa Species 0.000 claims description 12
- 235000019441 ethanol Nutrition 0.000 claims description 12
- 239000000203 mixture Substances 0.000 claims description 8
- 238000001035 drying Methods 0.000 claims description 5
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- 238000000605 extraction Methods 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 230000008014 freezing Effects 0.000 claims 1
- 238000007710 freezing Methods 0.000 claims 1
- 235000020985 whole grains Nutrition 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 16
- 229910001220 stainless steel Inorganic materials 0.000 description 12
- 238000005469 granulation Methods 0.000 description 9
- 230000003179 granulation Effects 0.000 description 9
- 239000003814 drug Substances 0.000 description 8
- 238000004108 freeze drying Methods 0.000 description 7
- 238000007654 immersion Methods 0.000 description 6
- 150000002576 ketones Chemical class 0.000 description 6
- 238000007873 sieving Methods 0.000 description 6
- 239000000243 solution Substances 0.000 description 6
- 241000244987 Daiswa polyphylla Species 0.000 description 5
- 239000010935 stainless steel Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 3
- 235000008216 herbs Nutrition 0.000 description 3
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 3
- 229930182490 saponin Natural products 0.000 description 3
- 150000007949 saponins Chemical class 0.000 description 3
- 239000000047 product Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- DBGSRZSKGVSXRK-UHFFFAOYSA-N 1-[2-[5-[2-(2,3-dihydro-1H-inden-2-ylamino)pyrimidin-5-yl]-1,3,4-oxadiazol-2-yl]acetyl]-3,6-dihydro-2H-pyridine-4-carboxylic acid Chemical compound C1C(CC2=CC=CC=C12)NC1=NC=C(C=N1)C1=NN=C(O1)CC(=O)N1CCC(=CC1)C(=O)O DBGSRZSKGVSXRK-UHFFFAOYSA-N 0.000 description 1
- 206010003399 Arthropod bite Diseases 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 206010010904 Convulsion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 206010031252 Osteomyelitis Diseases 0.000 description 1
- 208000004078 Snake Bites Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 238000007605 air drying Methods 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000013116 chronic cough Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930182470 glycoside Natural products 0.000 description 1
- 150000002338 glycosides Chemical class 0.000 description 1
- 239000008202 granule composition Substances 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 201000007227 lymph node tuberculosis Diseases 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000008736 traumatic injury Effects 0.000 description 1
- 201000008827 tuberculosis Diseases 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to Chinese medicinal granule technical fields, disclose a kind of preparation method with the careless river vehicle granule of antiasthmatic-antitussive and the careless river vehicle granule prepared by this method.Method includes the following steps: (1) takes dry careless river vehicle medicinal material, crush；(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume, filtering, obtained filter cake is mixed with the ethanol-acetone mixed solution of 8-15 times of volume of inventory；(3) ultrasonic extraction 2-3 times, filtering, filtrate decompression are concentrated to the concentrate that relative density is 1.2-1.3；(4) concentrate is mixed with pharmaceutically acceptable auxiliary material, it is dry, dried cream powder is collected, crushed 80 meshes, sets mixing channel mixing；(5) careless river vehicle cream powder is taken, is pelletized, whole grain.The careless river vehicle granule active component content with higher prepared using method of the present invention, and particle size uniformity.
Description
Technical field
The present invention relates to Chinese medicinal granule technical fields, and in particular to a kind of careless river vehicle with antiasthmatic-antitussive is matched
The preparation method of square particle and the careless river vehicle granule prepared by this method.
Background technique
Chinese medicinal granule is using traditional Chinese medicine medicine materical crude slice as raw material, by modern processing technique and pharmaceutical technology to medicinal material
Full ingredient the processing such as extract, separate, be concentrated, dry, pelletize and pack and obtain, without decocting, for be directly formulated with
The granule taken after mixing it with water.Chinese medicinal granule not only remained the effective component of the prepared slices of Chinese crude drugs, cures mainly and effect, but also had standard system
One, curative effect is stable, easy to carry and do not have the advantages of of medicine materical crude slice such as be easy to adjust, and is taken after mixing it with water, can be made with granule composition prescription
For the supplement of traditional Chinese herbal decoction and Chinese patent drug.
Careless river vehicle also known as paris polyphylla, be herbaceos perennial, main product in main product Guangdong, Guangxi, Jiangxi, Fujian,
The ground such as Shaanxi, Sichuan, main component are paris polyphylla saponin, have internal heat anticance, swelling and pain relieving, heat-clearing arresting convulsion, antibechic flat
Asthma and other effects, cures mainly the diseases such as carbuncle swells tuberculosis chronic cough, traumatic injury, snakebite and bugbite, scrofula, osteomyelitis.However, not having also at present
About careless river vehicle granule and its report of preparation process.
Summary of the invention
The purpose of the invention is to provide a kind of preparation method with the careless river vehicle granule of antiasthmatic-antitussive
And the careless river vehicle granule prepared by this method.
The present invention provides a kind of preparation methods with the careless river vehicle granule of antiasthmatic-antitussive, including following step
It is rapid:
(1) dry careless river vehicle medicinal material is taken, is crushed, obtaining granularity is 40-100 mesh powder；
(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume, filtering, by obtained filter cake and inventory 8-
The ethanol-acetone mixed solution mixing of 15 times of volumes；
(3) ultrasonic extraction 2-3 times, filtering, filtrate decompression are concentrated to the concentrate that relative density is 1.2-1.3；
(4) concentrate is mixed with pharmaceutically acceptable auxiliary material, it is dry, dried cream powder is collected, crushed 80
Mesh sets mixing channel mixing；
(5) careless river vehicle cream powder is taken, is pelletized, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle granule.
Preferably, the temperature of hot water is 40-60 DEG C, and the time of hot-water soak is 1-3 hours.
Preferably, for the ultrasonic frequency used during ultrasonic extraction for 50-125kHz, each extraction time is 30-60
Minute.
Preferably, the volume ratio of ethyl alcohol and acetone is 10:5-10 in the ethanol-acetone mixed solution.
Preferably, in step (4), the method for the drying is freeze-drying.
Preferably, the auxiliary material is at least one of soluble starch, starch, lactose, sucrose and dextrin.
Preferably, the auxiliary material is the mixture of starch, lactose and dextrin.
Preferably, the weight ratio of starch, lactose and dextrin is 1:0.01-0.5:0.1-2.
The present invention also provides the careless river vehicle granules prepared by the above method.
Preferably, the specification of the careless river vehicle granule is equivalent to 5-15 grams of medicinal material of careless river vehicle for every 1-3 grams.
It according to the method described in the present invention, can be by main active (such as paris polyphylla soap in careless river vehicle medicinal material
Glycosides) sufficiently extract, the active substances such as plant fiber can be effectively removed, the stability of drug is improved, easily stores, clothes
With conveniently.
Moreover, the grain forming of the careless river vehicle granule prepared according to the method described in the present invention is preferable, particle size
Uniformly.
In addition, directly prepared using careless river vehicle medicinal material as raw material in method of the present invention, it is easy to implement, it is easy real
Now industrialize.
Specific embodiment
Detailed description of the preferred embodiments below.It should be understood that described herein specific
Embodiment is merely to illustrate and explain the present invention, and is not intended to restrict the invention.
The endpoint of disclosed range and any value are not limited to the accurate range or value herein, these ranges or
Value should be understood as comprising the value close to these ranges or value.For numberical range, between the endpoint value of each range, respectively
It can be combined with each other between the endpoint value of a range and individual point value, and individually between point value and obtain one or more
New numberical range, these numberical ranges should be considered as specific open herein.
The preparation method of grass river vehicle granule of the present invention the following steps are included:
(1) dry careless river vehicle medicinal material is taken, is crushed, obtaining granularity is 40-100 mesh powder；
(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume, filtering, by obtained filter cake and inventory 8-
The ethanol-acetone mixed solution mixing of 15 times of volumes；
(3) ultrasonic extraction 2-3 times, filtering, filtrate decompression are concentrated to the concentrate that relative density is 1.2-1.3；
(4) concentrate is mixed with pharmaceutically acceptable auxiliary material, it is dry, dried cream powder is collected, crushed 80
Mesh sets mixing channel mixing；
(5) careless river vehicle cream powder is taken, is pelletized, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle granule.
In method of the present invention, it can adopt and careless river vehicle medicinal material is dried with the conventional methods in the field, example
Such as, natural air drying, drying etc..
In method of the present invention, it is preferable that by the careless river vehicle pulverizing medicinal materials of the drying to granularity be 40-100
Purpose powdery.
In method of the present invention, it is preferable that the temperature of hot water is 40-60 DEG C, and the time of hot-water soak is that 1-3 is small
When.
In method of the present invention, during hot-water soak, by volume, the inventory of hot water is careless river vehicle medicine
2-5 times of material specifically, such as can be 2 times, 3 times, 4 times or 5 times.
In method of the present invention, by volume, the inventory of the ethanol-acetone mixed solution is careless river vehicle medicine
8-15 times of material specifically, such as can be 8 times, 9 times, 10 times, 11 times, 12 times, 13 times, 14 times or 15 times.In the present invention
In the method, careless river vehicle medicinal material is made to feed intake with the ethanol-acetone mixed solution according to such volume ratio, it can be with
Sufficiently extract the main active in the careless river vehicle medicinal material.
In the ethanol-acetone mixed solution, the volume ratio of ethyl alcohol and acetone can be 10:5-10, specifically, such as
It can be 10:5,10:6,10:7,10:8,10:9 or 10:10.
In method of the present invention, it is preferable that the ultrasonic frequency used during ultrasonic extraction is 50-
125kHz, each extraction time are 30-60 minutes.In method of the present invention, keep careless river vehicle mixed in the ethanol-acetone
The time of ultrasonic extraction and frequency are closed in solution within above range, can sufficiently extract chief active in careless river vehicle at
Point, and active constituent can be prevented to be denaturalized, so that the careless river vehicle granule of preparation has preferable drug effect.
In method of the present invention, the strainer filtering that can use this field routine is filtered twice.Specific
In embodiment, filtering strainer used twice may each be the stainless steel cloth that mesh size is 200 mesh.
In step (4), the method for the drying is preferably freeze-dried.
In method of the present invention, it is preferable that the auxiliary material is soluble starch, starch, lactose, sucrose and dextrin
At least one of.It is further preferred that the auxiliary material is the mixing of starch, lactose and dextrin.When the auxiliary material is starch, cream
When the mixing of sugar and dextrin, the mixed weight ratio of three is preferably 1:0.01-0.5:0.1-2.
In method of the present invention, the feeding quantity of the auxiliary material makes the specification of careless river vehicle granule be every 1-3
Gram it is equivalent to 5-15 grams of medicinal material of careless river vehicle.
In method of the present invention, the method for the granulation can be to make the careless river vehicle cream powder be sieved to be made
Grain.
In method of the present invention, by making the particle obtained after granulation successively use 20 meshes and 50 mesh sieves,
The careless river vehicle granule of particle size uniformity can be obtained.
The present invention also provides the careless river vehicle granules prepared by the above method.
Preferably, the specification of the careless river vehicle granule is equivalent to 5-15 grams of medicinal material of careless river vehicle for every 1-3 grams, specifically
Ground, the every 1 gram careless river vehicle granule are equivalent to careless 5 grams of river vehicle raw medicinal herbs, and the every 2 grams careless river vehicle granules are equivalent to
Careless 10 grams of river vehicle raw medicinal herbs, the every 3 grams careless river vehicle granules are equivalent to careless 15 grams of river vehicle raw medicinal herbs.
The present invention will be described in detail by way of examples below.
Embodiment 1
(1) the careless river vehicle medicinal material for taking 1kg dry, is crushed to 80 mesh, adds 3.5 times of inventory of (50 DEG C) of hot water immersions 2 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 12 times of inventory of ethanol-acetone mixed solution (ethyl alcohol: third
Ketone=10:8) mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are each to extract 45 minutes, with the stainless steel of 200 mesh
Silk screen filter, filtrate decompression are concentrated to the concentrate that relative density is 1.25；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) careless river vehicle cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle formula
Grain sample A1.
Embodiment 2
(1) the careless river vehicle medicinal material for taking 1kg dry, is crushed to 100 mesh, adds 4 times of inventory of (40 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 13 times of inventory of ethanol-acetone mixed solution (ethyl alcohol: third
Ketone=10:9) mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are each to extract 45 minutes, with the stainless steel of 200 mesh
Silk screen filter, filtrate decompression are concentrated to the concentrate that relative density is 1.22；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) careless river vehicle cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle formula
Grain sample A2.
Embodiment 3
(1) the careless river vehicle medicinal material for taking 1kg dry, is crushed to 50 mesh, adds 5 times of inventory of (60 DEG C) of hot water immersions 2 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 10 times of inventory of ethanol-acetone mixed solution (ethyl alcohol: third
Ketone=10:7) mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are each to extract 45 minutes, with the stainless steel of 200 mesh
Silk screen filter, filtrate decompression are concentrated to the concentrate that relative density is 1.24；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) careless river vehicle cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle formula
Grain sample A3.
Embodiment 4
(1) the careless river vehicle medicinal material for taking 1kg dry, is crushed to 100 mesh, adds 5 times of inventory of (45 DEG C) of hot water immersions 2 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 9 times of inventory of ethanol-acetone mixed solution (ethyl alcohol: third
Ketone=10:6) mixing, ultrasonic extraction 3 times under the ultrasonic frequency of 90kHz are each to extract 45 minutes, with the stainless steel of 200 mesh
Silk screen filter, filtrate decompression are concentrated to the concentrate that relative density is 1.28；
(2) be added in concentrate 100g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) careless river vehicle cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle formula
Grain sample A4.
Embodiment 5
(1) the careless river vehicle medicinal material for taking 1kg dry, is crushed to 60 mesh, adds 2 times of inventory of (40 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 15 times of inventory of ethanol-acetone mixed solution (ethyl alcohol: third
Ketone=10:5) mixing, ultrasonic extraction 2 times under the ultrasonic frequency of 125kHz are extracted 60 minutes every time, stainless with 200 purposes
Steel wire net filtration, filtrate decompression are concentrated to the concentrate that relative density is 1.2；
(2) be added in concentrate 80g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) careless river vehicle cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle formula
Grain sample A5.
Embodiment 6
(1) the careless river vehicle medicinal material for taking 1kg dry, is crushed to 100 mesh, adds 5 times of inventory of (60 DEG C) of hot water immersions 3 small
When, with the stainless steel wire net filtration of 200 mesh, by gained filter cake and 8 times of inventory of ethanol-acetone mixed solution (ethyl alcohol: third
Ketone=10:10), ultrasonic extraction 3 times under the ultrasonic frequency of 50kHz are extracted 30 minutes, every time with the stainless steel wire of 200 mesh
Net filtration, filtrate decompression are concentrated to the concentrate that relative density is 1.3；
(2) be added in concentrate 50g starch, lactose and dextrin mixture (three's weight ratio is 1:0.25:1) into
Row mixing, freeze-drying collect dried cream powder, crushed 80 meshes, set mixing channel mixing；
(3) careless river vehicle cream powder, sieving granulation are taken, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle formula
Grain sample A6.
Embodiment 7
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that ethanol-acetone mixes in step (1)
The ethyl alcohol of solution: acetone=10:3, so that grass river vehicle granule sample A7 be made.
Embodiment 8
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that ethanol-acetone mixes in step (1)
The ethyl alcohol of solution: acetone=10:12, so that grass river vehicle granule sample A8 be made.
Comparative example 1
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that ethanol-acetone mixes in step (1)
The inventory of solution is 5 times of careless river vehicle medicinal material, so that grass river vehicle granule sample D1 be made.
Comparative example 2
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that ethanol-acetone mixes in step (1)
The inventory of solution is 20 times of careless river vehicle medicinal material, so that grass river vehicle granule sample D2 be made.
Comparative example 3
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that replacing second with ethyl alcohol in step (1)
Alcohol-acetone mixed solution, so that grass river vehicle granule sample D3 be made.
Comparative example 4
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that replacing second with acetone in step (1)
Alcohol-acetone mixed solution, so that grass river vehicle granule sample D4 be made.
Comparative example 5
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that not firm heat application water logging in step (1)
The step of bubble, so that grass river vehicle granule sample D5 be made.
Comparative example 6
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that not firm Shih-chao's sound mentions in step (1)
The step of taking, so that grass river vehicle granule sample D6 be made.
Comparative example 7
Careless river vehicle granule is prepared according to the method for embodiment 1, the difference is that the particle in step (3) after granulation
Without 20 meshes and 50 mesh sieves, so that grass river vehicle granule sample D7 be made.
Test case
(1) the paris polyphylla saponin content in the careless river vehicle granule sample prepared to above-described embodiment and comparative example
It is detected, detects the chromatographic column used as C18 chromatographic column.
(2) partial size of the careless river vehicle granule sample of above-described embodiment and comparative example preparation is detected using particles distribution instrument
Distribution situation, and analytical calculation partial size is the granule number percentage U of the partial size within the scope of 0.25-0.35mm0.25-0.35。
As a result as shown in table 1 below.
Table 1
| Embodiment number | Paris polyphylla saponin content (mg/g) | U0.25-0.35 |
| Embodiment 1 | 45 | 93% |
| Embodiment 2 | 46 | 92% |
| Embodiment 3 | 43 | 90% |
| Embodiment 4 | 46 | 89% |
| Embodiment 5 | 57 | 94% |
| Embodiment 6 | 70 | 91% |
| Embodiment 7 | 31 | 89% |
| Embodiment 8 | 33 | 87% |
| Comparative example 1 | 27 | 88% |
| Comparative example 2 | 26 | 87% |
| Comparative example 3 | 23 | 85% |
| Comparative example 4 | 24 | 83% |
| Comparative example 5 | 22 | 85% |
| Comparative example 6 | 15 | 89% |
| Comparative example 7 | 45 | 25% |
By the result of table 1 can be seen that using method of the present invention preparation careless river vehicle granule have compared with
High active component content, and particle size uniformity.
The preferred embodiment of the present invention has been described above in detail, and still, the present invention is not limited thereto.In skill of the invention
In art conception range, can with various simple variants of the technical solution of the present invention are made, including each technical characteristic with it is any its
Its suitable method is combined, and it should also be regarded as the disclosure of the present invention for these simple variants and combination, is belonged to
Protection scope of the present invention.
Claims (10)
1. a kind of preparation method with the careless river vehicle granule of antiasthmatic-antitussive, which comprises the following steps:
(1) dry careless river vehicle medicinal material is taken, is crushed, obtaining granularity is 40-100 mesh powder；
(2) powder obtained with the hot-water soak step (1) of 2-5 times of volume, filtering, by obtained filter cake and 8-15 times of inventory
The ethanol-acetone mixed solution of volume mixes；
(3) ultrasonic extraction 2-3 times, filtering, filtrate decompression are concentrated to the concentrate that relative density is 1.2-1.3；
(4) concentrate is mixed with pharmaceutically acceptable auxiliary material, it is dry, dried cream powder is collected, crushed 80 meshes,
Set mixing channel mixing；
(5) careless river vehicle cream powder is taken, is pelletized, particle successively uses 20 meshes and 50 mesh sieves, obtains careless river vehicle granule.
2. the time of hot-water soak is the method according to claim 1, wherein the temperature of hot water is 40-60 DEG C
1-3 hours.
3. the method according to claim 1, wherein the ultrasonic frequency used during ultrasonic extraction is 50-
125kHz, each extraction time are 30-60 minutes.
4. method described in any one of -3 according to claim 1, which is characterized in that in the ethanol-acetone mixed solution
The volume ratio of ethyl alcohol and acetone is 10:5-10.
5. the method according to claim 1, wherein the method for the drying is that freezing is dry in step (4)
It is dry.
6. the method according to claim 1, wherein the auxiliary material is soluble starch, starch, lactose, sucrose
At least one of with dextrin.
7. according to the method described in claim 6, it is characterized in that, the auxiliary material is the mixture of starch, lactose and dextrin.
8. the method according to the description of claim 7 is characterized in that the weight ratio of starch, lactose and dextrin is 1:0.01-0.5:
0.1-2。
9. the careless river vehicle granule of the preparation of the method as described in any one of claim 1-8.
10. grass river according to claim 9 vehicle granule, which is characterized in that the specification of grass river vehicle granule
5-15 grams of medicinal material of careless river vehicle is equivalent to for every 1-3 grams.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811541536.9A CN109646406A (en) | 2018-12-17 | 2018-12-17 | The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811541536.9A CN109646406A (en) | 2018-12-17 | 2018-12-17 | The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN109646406A true CN109646406A (en) | 2019-04-19 |
Family
ID=66113251
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201811541536.9A Withdrawn CN109646406A (en) | 2018-12-17 | 2018-12-17 | The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN109646406A (en) |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903307A (en) * | 2006-08-01 | 2007-01-31 | 李华林 | Granule or powder preparation for anti-cold and febrifugal electuary, and its extraction method |
| CN101401897A (en) * | 2008-11-06 | 2009-04-08 | 云南白药集团股份有限公司 | Edulcoration purification process for rhizoma paris saponin extract solution |
| CN101543571A (en) * | 2008-03-24 | 2009-09-30 | 北京凯瑞创新医药科技有限公司 | Rhizoma paridis total aglycone sustained-release pellet as well as preparation method and application thereof |
| CN101601798A (en) * | 2009-07-01 | 2009-12-16 | 南京泽朗医药科技有限公司 | A kind of preparation method of paris polyphylla saponin |
| CN101912514A (en) * | 2010-07-27 | 2010-12-15 | 天津大学 | Paris rhizome total saponin capsules with anti-tumor effect and preparation method thereof |
| CN104623242A (en) * | 2015-01-09 | 2015-05-20 | 青岛市肿瘤医院 | Traditional Chinese medicine formula for treating lung cancer and preparation method of traditional Chinese medicine formula |
| CN106236971A (en) * | 2016-08-29 | 2016-12-21 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating chronic nephritis |
| WO2016204474A3 (en) * | 2015-06-18 | 2017-02-16 | 주식회사대성미생물연구소 | Veterinary composition for treating animal enteritis containing rifaximin crystalline forms |
-
2018
- 2018-12-17 CN CN201811541536.9A patent/CN109646406A/en not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903307A (en) * | 2006-08-01 | 2007-01-31 | 李华林 | Granule or powder preparation for anti-cold and febrifugal electuary, and its extraction method |
| CN101543571A (en) * | 2008-03-24 | 2009-09-30 | 北京凯瑞创新医药科技有限公司 | Rhizoma paridis total aglycone sustained-release pellet as well as preparation method and application thereof |
| CN101401897A (en) * | 2008-11-06 | 2009-04-08 | 云南白药集团股份有限公司 | Edulcoration purification process for rhizoma paris saponin extract solution |
| CN101601798A (en) * | 2009-07-01 | 2009-12-16 | 南京泽朗医药科技有限公司 | A kind of preparation method of paris polyphylla saponin |
| CN101912514A (en) * | 2010-07-27 | 2010-12-15 | 天津大学 | Paris rhizome total saponin capsules with anti-tumor effect and preparation method thereof |
| CN104623242A (en) * | 2015-01-09 | 2015-05-20 | 青岛市肿瘤医院 | Traditional Chinese medicine formula for treating lung cancer and preparation method of traditional Chinese medicine formula |
| WO2016204474A3 (en) * | 2015-06-18 | 2017-02-16 | 주식회사대성미생물연구소 | Veterinary composition for treating animal enteritis containing rifaximin crystalline forms |
| CN106236971A (en) * | 2016-08-29 | 2016-12-21 | 长沙佰顺生物科技有限公司 | A kind of Chinese medicine composition treating chronic nephritis |
Non-Patent Citations (1)
| Title |
|---|
| 陈清: "HPLC比较醇提重楼及其颗粒中重楼皂苷I，Ⅱ的含量", 《中国实验方剂学杂志》 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN113599363B (en) | Preparation method of Xinmaitong capsules | |
| CN1788783A (en) | Granule containing ginseng ,Siberian cocklebur ,lagehead atractylodes and its preparation method | |
| CN104069344A (en) | Traditional Chinese medicine composition for treating cancer and preparation and preparation method thereof | |
| CN107519293A (en) | A kind of benzydamine micropill and preparation method thereof | |
| CN109646406A (en) | The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method | |
| CN109528825A (en) | A kind of salvia bowleyana Dunn granule and preparation method thereof with activating microcirculation and removing stasis medicinal and menstruction regulating and pain relieving | |
| CN109528955A (en) | The Guizhou Province song granule for having effects that the preparation method of the Guizhou Province song granule of spleen benefiting and stimulating the appetite and clearing away summer-heat and eliminating dampness and being prepared by this method | |
| CN109528786A (en) | A kind of HERBA BUPLEURI granule and preparation method thereof | |
| CN107412462B (en) | Preparation method of Huanglong cough and asthma capsule | |
| CN109528795A (en) | A kind of hempleaf groundsel herb granule and preparation method thereof | |
| CN109528818A (en) | A kind of rabdosia lophanthide granule and preparation method thereof for treating acute icteric hepatitis | |
| CN109646407A (en) | For the preparation method of calm, cooling, decompression Cortex Cinnamomi granule and by the granule of this method preparation | |
| CN109568468A (en) | A kind of dye yam granule and preparation method thereof | |
| CN109646405A (en) | A kind of monkey mushroom granule and preparation method thereof | |
| CN109528835A (en) | A kind of trollflower granule and preparation method thereof | |
| CN111643594B (en) | Traditional Chinese medicine composition for treating opioid-related constipation, preparation method and application thereof | |
| CN109846834A (en) | The granule for having effects that the preparation method of clearing heat and detoxicating and cool blood detumescence Manyflower Gueldenstaedtid Herb granule and being prepared by this method | |
| CN109528801A (en) | A kind of Bai Yun Shen granule and preparation method thereof | |
| CN109528781A (en) | A kind of lichen granule and preparation method thereof | |
| CN109846829A (en) | One seed ginseng potato granule and preparation method thereof | |
| CN109846836A (en) | Wallich swallowwort root granule for treating the preparation method of the wallich swallowwort root granule of lumbago due to the kidney deficiency and being prepared by this method | |
| CN109602823A (en) | A kind of cayropteris incana granule and preparation method thereof | |
| WO2017101210A1 (en) | Gastritis treating traditional chinese medicine composition preparation method and preparation | |
| CN107095979B (en) | Traditional Chinese medicine composition suitable for treating hyperlipidemia, preparation method and application thereof | |
| CN109528809A (en) | A kind of clover granule and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| WW01 | Invention patent application withdrawn after publication | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20190419 |