CN104623242A - Traditional Chinese medicine formula for treating lung cancer and preparation method of traditional Chinese medicine formula - Google Patents
Traditional Chinese medicine formula for treating lung cancer and preparation method of traditional Chinese medicine formula Download PDFInfo
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- CN104623242A CN104623242A CN201510011951.3A CN201510011951A CN104623242A CN 104623242 A CN104623242 A CN 104623242A CN 201510011951 A CN201510011951 A CN 201510011951A CN 104623242 A CN104623242 A CN 104623242A
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Abstract
The invention belongs to the technical field of the traditional Chinese medicines, and particularly relates to a traditional Chinese medicine formula for treating a lung cancer and a preparation method of the traditional Chinese medicine formula. The traditional Chinese medicine is prepared from the following traditional Chinese medicinal materials in parts by weight: 5-10 parts of paris polyphylla, 5-8 parts of sculellaria barbata, 5-8 parts of gynostemma pentaphyllum, 3-8 parts of cephalotaxus oliveri, 1-2 parts of grass fritillaria, 3-8 parts of coriaceousleaf actinidia fruit, 3-8 parts of macaranga tanarius, 3-5 parts of oldenlandia diffusa, 3-8 parts of tangerine pith, 3-5 parts of lily, 3-5 parts of fritillaria, 3-5 parts of asparagus cochinchinensis, 3-5 parts of ginkgo nut, 3-5 parts of folium agaves america nae, 3-8 parts of poria cocos, 3-8 parts of rhodiola rosea and 3-8 parts of gynostemma pentaphylla; and the preparation method is preparing granules. According to the traditional Chinese medicine formula, through the efficacies of the traditional Chinese medicine for supporting the healthy energy, clearing away heat and toxic materials, reducing phlegm and resolving masses, under the assist of the medicines with the effects of tonifying deficiency and tonifying qi, tumor breeding is inhibited; tumor diffusion transfer is controlled; the immunity is enhanced; the paint of patients is relieved; and the life of the patients is saved.
Description
Technical field
The invention belongs to field of traditional Chinese medicine technology, particularly a kind of Chinese medicine formula for the treatment of pulmonary carcinoma and preparation method thereof.
Background technology
It is the fastest that pulmonary carcinoma is that M & M increases, to one of population health and the maximum malignant tumor of life threat.The many countries of immediate and mid-term all report that the M & M of pulmonary carcinoma all obviously increases, and male lung cancer M & M all accounts for first of all malignant tumor, and women's sickness rate accounts for second, and mortality rate accounts for second.The cause of disease of pulmonary carcinoma is still not exclusively clear and definite so far, and great mass of data shows, long-term a large amount of smoking and pulmonary carcinoma have very close relationship.Existing research proves: the probability that long-term a large amount of smoker suffers from pulmonary carcinoma is 10 ~ 20 times of non-smoker, and the age starting smoking is less, and the probability of suffering from pulmonary carcinoma is higher.
Chemotherapy is the primary treatments of pulmonary carcinoma, and the pulmonary carcinoma of more than 90% needs to accept chemotherapeutic treatment.But chemotherapy effectively can hinder cancerous cell, can normal cell be killed and wounded and cause the immunologic function of patient suppressed again simultaneously, occur more complication, bring very big damage to patient body.Chinese patent (CN103041291A) discloses a kind of Chinese medicine for the treatment of pulmonary carcinoma, has the stable state of an illness to patients with lung cancer, improves the effect of symptom, but lacks clinical data support, and effect needs to be investigated, and actual popularization has certain restriction.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicine formula for the treatment of pulmonary carcinoma and preparation method thereof, by the effect of the strengthening the body resistance of Chinese medicine, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, auxiliary with the medicine of tonify deficiency QI invigorating, Tumor suppression is bred, control tumor diffusion transfer, enhancing immunity, alleviates patient's misery, saves patients ' lives.
The invention provides a kind of Chinese medicine formula for the treatment of pulmonary carcinoma, formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Paridis 5 ~ 10 parts, Herba Scutellariae Barbatae 5 ~ 8 parts, Herba Gynostemmatis 5 ~ 8 parts, Cephalotaxus oliveri 3 ~ 8 parts, Bulbus Iphigeniae Indicae 1 ~ 2 part, Herba Actinidiae coriacea 3 ~ 8 parts, Macaranga tanarius 3 ~ 8 parts, Herba Hedyotidis Diffusae 3 ~ 5 parts, Vascular aurantii 3 ~ 8 parts, Flos Lilii viriduli 3 ~ 5 parts, Bulbus Fritillariae Cirrhosae 3 ~ 5 parts, Radix Asparagi 3 ~ 5 parts, ginkgo nut 3 ~ 5 parts, Folium Agaves variegatae 3 ~ 5 parts, 3 ~ 8 parts, Poria, Radix Rhodiolae 3 ~ 8 parts, Herb Gynostemmae Pentaphylli 3 ~ 8 parts.
More preferably formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Paridis 8 parts, Herba Scutellariae Barbatae 6 parts, Herba Gynostemmatis 6 parts, Cephalotaxus oliveri 6 parts, Bulbus Iphigeniae Indicae 1 part, Herba Actinidiae coriacea 5 parts, Macaranga tanarius 5 parts, Herba Hedyotidis Diffusae 4 parts, Vascular aurantii 5 parts, Flos Lilii viriduli 4 parts, Bulbus Fritillariae Cirrhosae 4 parts, Radix Asparagi 4 parts, ginkgo nut 4 parts, Folium Agaves variegatae 4 parts, 6 parts, Poria, Radix Rhodiolae 5 parts, Herb Gynostemmae Pentaphylli 6 parts.
Preparation method step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, extracted twice liquid filters after merging, and is concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Pharmacology analysis:
Rhizoma Paridis: hardship is slightly cold mild toxicity, enters Liver Channel.Function heat-clearing and toxic substances removing, reducing swelling and alleviating pain, relieve dizziness, high fever, infantile convulsions, epilepsy, etc. and determine convulsion; Cure mainly digestive tract carcinoma, pulmonary carcinoma, the cerebral tumor and malignant lymphoma, the clinical stagnant malignant lymphoma of pyretic toxicity harmony, pulmonary carcinoma, nasopharyngeal carcinoma, the cerebral tumor and the digestive system tumor of being used for is as gastric cancer, the esophageal carcinoma, hepatocarcinoma etc.
Herba Scutellariae Barbatae: pungent, flat.There is heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, reducing swelling and alleviating pain, anticancer effect; Appendicitis curing, hepatitis, stomachache, early hepatocarcinoma, pulmonary carcinoma, cervical cancer, mastitis etc.; External is controlled pain furuncle and is treated, the diseases such as treating swelling and pain by traumatic injury.
Herba Gynostemmatis: bitter in the mouth, micro-sweet, cool in nature.Effect replenishing QI to invigorate the spleen, preventing phlegm from forming and stopping coughing, heat-clearing and toxic substances removing; There is blood fat reducing, blood sugar lowering, antitumor, defying age, the liver protecting and strengthen the effects such as body immune function.Be mainly used in the propagation of the cancerous cell such as Hepatoma therapy, pulmonary carcinoma, uterus carcinoma, skin carcinoma, have obvious inhibitory action.
Cephalotaxus oliveri: nature and flavor are bitter, puckery, cold.Cure mainly hematological system tumor and some other malignant solid tumor.
Bulbus Iphigeniae Indicae: bitter, temperature, poisonous.Cold expelling, relievings asthma, relieving cough and resolving phlegm, analgesia, anticancer; Control tracheitis, asthma, breast carcinoma, nasopharyngeal carcinoma.
Herba Actinidiae coriacea: sour and astringent, warm in nature.Effect curing oncoma.
Macaranga tanarius: cure mainly constipation, malignant tumor, nervous system and cardiovascular system diseases.
Herba Hedyotidis Diffusae: bitter in the mouth, light, cold in nature; Primary efficacy is heat-clearing and toxic substances removing, medicinal powder for relieving pain knot, promoting urination to remove dampness; Cure mainly dyspnea and cough due to lung-heat, laryngopharynx swelling and pain, acute appendicitis, furuncle and phyma skin infection, venom, the puckery pain of pyretic stranguria, edema, dysentery, enteritis, jaundice due to damp-heat, be good at the multiple cancerous protuberance for the treatment of.
Vascular aurantii: bitter in the mouth, sweet, property is put down.Return spleen, lung meridian; Effect dredging collateral, preventing phlegm from forming and stopping coughing; For cough with copious phlegm, the breast side of body is had a pain.
Flos Lilii viriduli: bitter in the mouth, cold nature.Enter the heart, lung meridian.Nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.There is nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN, as all sorts of flowers cream.Control chronic cough of deficiency lung, chronic cough is spat blood, as baihe gujin decoction.Have clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep etc.
Bulbus Fritillariae Cirrhosae: this product bitter in the mouth, cold nature, returns lung meridian, has the merit of clearing heat, eliminating phlegm, relieving cough, can be used for treatment expectorant heat syndrome cough and breathes heavily, yellow thick card of coughing up phlegm; To hold concurrently again sugariness, therefore kind nourishing the lung to arrest cough, treatment lung has the card that scorching cough expectorant is few and sticky, and the deficiency syndrome such as deficiency of YIN cough caused by dryness chronic cough; Also have the merit of eliminating stagnation dissipating depression of QI, the uncomfortable in chest vexed card for the treatment of caused by combination of phlegm and heat, and the disease such as scrofula sucutaneous nodule.
Radix Asparagi: cold in nature, sweet in the mouth, micro-hardship.There is replenishing YIN and removing heat, effect of lung moistening nourishing kidney.For the disease such as control fever due to yin deficiency, lung abscess, quench one's thirst.There is hemocytes increasing, strengthen the effect of reticuloendothelial system phagocytic function and prolongation antibody life period.
Ginkgo nut: the flat sweet in the mouth of property is pained, enter lung kidney channel, gas of astringing the lung, relieving asthma and cough, eliminate the phlegm, cough-relieving, lung moistening, the effect such as Dingchuan.
Folium Agaves variegatae: property is put down, sweet in the mouth, micro-pungent.Effect nourishing the lung to arrest cough, cooling blood for hemostasis, heat-clearing and toxic substances removing.
Poria: there is antioxidation, anti-aging, increase immunity, improve the effect of brain cell activity.Poria has stronger diuresis, can treat nephritis, heart failure edema.Also have sedation in addition, effective to neurasthenia.Lightly seasoned property is put down, kind benefiting QI and nourishing blood, and mind tranquilizing and the heart calming, relieves internal heat anticancer; Mild in medicine property and, dampness removing and do not hinder healthy energy, contained pachymic acid has the effect of enhancing immunity, antitumor and calmness, blood sugar lowering etc.; Can be relaxed gastrointestinal smooth muscle, the effects such as gastric acid secretion inhibiting, prevents hepatic necrosis, antibacterial.
Radix Rhodiolae: can QI invigorating lung heat clearing, Fructus Alpiniae Oxyphyllae is nourished heart, and sweetness and bitterness is put down.Return lung heart channel.Benefiting QI for activating blood circulation, promotes blood circulation and relievings asthma.For blood stasis due to qi deficiency, obstruction of qi in the chest and cardialgia, apoplectic hemiplegia, asthenia is panted.
Herb Gynostemmae Pentaphylli: sweet in the mouth, hardship, cold nature.Return lung meridian, spleen channel, kidney channel.Energy QI invigorating, calms the nerves, blood pressure lowering, heat-clearing and toxic substances removing, eliminating phlegm and stopping cough.
Chinese medicine of the present invention, by the effect of the strengthening the body resistance of Chinese medicine, heat-clearing and toxic substances removing, dissipating phlegm and resolving masses, auxiliary with the medicine of tonify deficiency QI invigorating, Tumor suppression is bred, and control tumor diffusion transfer, enhancing immunity, alleviates patient's misery, saves patients ' lives.
Outcome measure:
1.1 physical data
The present invention carries out clinical observation treatment to 118 routine patients with lung cancer, wherein age reckling 23 years old, the maximum 76 years old, 52 years old mean age; Man 63 example, female 55 example.
1.2 Therapeutic Method
Therapeutic Method: patient takes granule of the present invention, 3 times on the one, serve on 1 month.
1.3 efficacy assessment standard
Clinical disease criterion of therapeutical effect by cough, cough up phlegm, expectorant blood, uncomfortable in chest, chest pain, the common sympton such as out of breath, heating by light, in, be heavily divided into 3 grades, be designated as 2,4,6 points respectively, carrying out accumulation before the treatment afterwards contrasts, by integration than method Estimating curative effect.
Effective: after treatment, symptom and sign integrated value declines >=2/3;
Effective: after treatment, symptom and sign integrated value declines >=1/3, but < 2/3;
Invalid: not reach effective standard person.
1.4 therapeutic effect:
Effective 93 examples, account for 78.8%, and effective 24 examples, account for 20.3%, and invalid 1 example, accounts for 0.9%, total effective rate 99.1%.
1.5 model cases:
Case 1: Cui so-and-so, man, 76 years old.Patient because of dry cough, become thin, at hospital admission, make a definite diagnosis " pulmonary carcinoma " through CT examination, chemotherapy 3 times, patient's nausea and vomiting, weak, spirit poor, stopping chemotherapy, give Chinese medicine of the present invention and treat, effective after January, clinical symptom disappearance, follows up a case by regular visits to half a year without recurrence.
Case 2: stone so-and-so, female, 68 years old.Patient's cough, uncomfortable in chest, dyspnea, spit the band blood streak, lean body mass two months, go to see a doctor, CT examination is diagnosed as: right lung central type carcinoma of lung, is adenosquamous carcinoma through bronchoscope pathological diagnosis, carry out doctor trained in Western medicine radiation and chemotherapy effect undesirable, transfer Chinese traditional treatment to.When coming, patient coughs seriously, the amount of spitting is large, health is obviously become thin, right chest pain pain is serious, inappetence, pale tongue, and tongue is thick, thready and weak pulse in vain, gives Chinese medicine of the present invention and treats, and after January effectively, clinical symptom disappearance, follows up a case by regular visits to half a year without recurrence.
Detailed description of the invention
Embodiment 1:
Treat a Chinese medicine formula for pulmonary carcinoma, formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Paridis 8 parts, Herba Scutellariae Barbatae 6 parts, Herba Gynostemmatis 6 parts, Cephalotaxus oliveri 6 parts, Bulbus Iphigeniae Indicae 1 part, Herba Actinidiae coriacea 5 parts, Macaranga tanarius 5 parts, Herba Hedyotidis Diffusae 4 parts, Vascular aurantii 5 parts, Flos Lilii viriduli 4 parts, Bulbus Fritillariae Cirrhosae 4 parts, Radix Asparagi 4 parts, ginkgo nut 4 parts, Folium Agaves variegatae 4 parts, 6 parts, Poria, Radix Rhodiolae 5 parts, Herb Gynostemmae Pentaphylli 6 parts.
Preparation method step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, extracted twice liquid filters after merging, and is concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Embodiment 2:
Treat a Chinese medicine formula for pulmonary carcinoma, formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Paridis 5 parts, Herba Scutellariae Barbatae 8 parts, Herba Gynostemmatis 5 parts, Cephalotaxus oliveri 8 parts, Bulbus Iphigeniae Indicae 1 part, Herba Actinidiae coriacea 8 parts, Macaranga tanarius 3 parts, Herba Hedyotidis Diffusae 5 parts, Vascular aurantii 3 parts, Flos Lilii viriduli 5 parts, Bulbus Fritillariae Cirrhosae 3 parts, Radix Asparagi 5 parts, ginkgo nut 3 parts, Folium Agaves variegatae 5 parts, 3 parts, Poria, Radix Rhodiolae 8 parts, Herb Gynostemmae Pentaphylli 3 parts.
Preparation method step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, extracted twice liquid filters after merging, and is concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Embodiment 3:
Treat a Chinese medicine formula for pulmonary carcinoma, formulated by the raw material of Chinese medicine of following parts by weight: Rhizoma Paridis 10 parts, Herba Scutellariae Barbatae 5 parts, Herba Gynostemmatis 8 parts, Cephalotaxus oliveri 3 parts, Bulbus Iphigeniae Indicae 2 parts, Herba Actinidiae coriacea 3 parts, Macaranga tanarius 8 parts, Herba Hedyotidis Diffusae 3 parts, Vascular aurantii 8 parts, Flos Lilii viriduli 3 parts, Bulbus Fritillariae Cirrhosae 5 parts, Radix Asparagi 3 parts, ginkgo nut 5 parts, Folium Agaves variegatae 3 parts, 8 parts, Poria, Radix Rhodiolae 3 parts, Herb Gynostemmae Pentaphylli 8 parts.
Preparation method step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, extracted twice liquid filters after merging, and is concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
Below the present invention be described in detail, the above, be only the preferred embodiment of the present invention, when not limiting the scope of the present invention, namely allly does impartial change according to the application's scope and modify, all should still belong in covering scope of the present invention.
Claims (3)
1. treat a Chinese medicine formula for pulmonary carcinoma, it is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Rhizoma Paridis 5 ~ 10 parts, Herba Scutellariae Barbatae 5 ~ 8 parts, Herba Gynostemmatis 5 ~ 8 parts, Cephalotaxus oliveri 3 ~ 8 parts, Bulbus Iphigeniae Indicae 1 ~ 2 part, Herba Actinidiae coriacea 3 ~ 8 parts, Macaranga tanarius 3 ~ 8 parts, Herba Hedyotidis Diffusae 3 ~ 5 parts, Vascular aurantii 3 ~ 8 parts, Flos Lilii viriduli 3 ~ 5 parts, Bulbus Fritillariae Cirrhosae 3 ~ 5 parts, Radix Asparagi 3 ~ 5 parts, ginkgo nut 3 ~ 5 parts, Folium Agaves variegatae 3 ~ 5 parts, 3 ~ 8 parts, Poria, Radix Rhodiolae 3 ~ 8 parts, Herb Gynostemmae Pentaphylli 3 ~ 8 parts.
2. a kind of Chinese medicine formula for the treatment of pulmonary carcinoma as claimed in claim 1, is characterized in that by the raw material of Chinese medicine of following parts by weight formulated: Rhizoma Paridis 8 parts, Herba Scutellariae Barbatae 6 parts, Herba Gynostemmatis 6 parts, Cephalotaxus oliveri 6 parts, Bulbus Iphigeniae Indicae 1 part, Herba Actinidiae coriacea 5 parts, Macaranga tanarius 5 parts, Herba Hedyotidis Diffusae 4 parts, Vascular aurantii 5 parts, Flos Lilii viriduli 4 parts, Bulbus Fritillariae Cirrhosae 4 parts, Radix Asparagi 4 parts, ginkgo nut 4 parts, Folium Agaves variegatae 4 parts, 6 parts, Poria, Radix Rhodiolae 5 parts, Herb Gynostemmae Pentaphylli 6 parts.
3. the preparation method of the Chinese medicine formula of a treatment pulmonary carcinoma according to claim 1, it is characterized in that step is as follows: choose each component of medicine in proportion, grind to form smalls, mix homogeneously, 65% alcohol heating reflux mixture being added 8 times extracts 45 minutes, and alcohol heating reflux remainder being added again 6 times 65% extracts 30 minutes, filters after extracted twice liquid merges, be concentrated into the clear paste that density is 1.50, for subsequent use; In clear paste, add dextrin, sucrose packs after making granule.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012653A (en) * | 2015-08-21 | 2015-11-04 | 王璐 | Veterinary medicine for treating pneumonia of domestic animals |
| CN109646406A (en) * | 2018-12-17 | 2019-04-19 | 江西赣隆药业有限公司 | The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method |
| IT201800003398A1 (en) * | 2018-03-09 | 2019-09-09 | Aboca Spa Societa Agricola | NEW ACTIVE INGREDIENTS FOR THE TREATMENT OF CANCER |
-
2015
- 2015-01-09 CN CN201510011951.3A patent/CN104623242A/en active Pending
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105012653A (en) * | 2015-08-21 | 2015-11-04 | 王璐 | Veterinary medicine for treating pneumonia of domestic animals |
| IT201800003398A1 (en) * | 2018-03-09 | 2019-09-09 | Aboca Spa Societa Agricola | NEW ACTIVE INGREDIENTS FOR THE TREATMENT OF CANCER |
| CN109646406A (en) * | 2018-12-17 | 2019-04-19 | 江西赣隆药业有限公司 | The careless river vehicle granule for having effects that the preparation method of the careless river vehicle granule of antiasthmatic-antitussive and being prepared by this method |
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Application publication date: 20150520 |