CN106490611A - A kind of Radix Notoginseng flower composition and its preparation method and application - Google Patents
A kind of Radix Notoginseng flower composition and its preparation method and application Download PDFInfo
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- CN106490611A CN106490611A CN201610914256.2A CN201610914256A CN106490611A CN 106490611 A CN106490611 A CN 106490611A CN 201610914256 A CN201610914256 A CN 201610914256A CN 106490611 A CN106490611 A CN 106490611A
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- radix notoginseng
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- notoginseng flower
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/489—Sophora, e.g. necklacepod or mamani
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
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- Chemical & Material Sciences (AREA)
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of Radix Notoginseng flower composition and its preparation method and application, including following component：5 ~ 60 parts of flower of Radix Notoginseng, 5 ~ 60 parts of Fructus Lycii, 5 ~ 50 parts of Flos Chrysanthemi, 5 ~ 40 parts of Flos Sophorae, 0 ~ 30 part of Herba Lophatheri, 0 ~ 30 part of Folium Nelumbinis, 0 ~ 20 part of Radix Puerariae, 0 ~ 20 part of Semen Cassiae.Medicine, field of health care food are applied to according to the Radix Notoginseng flower composition obtained by formula.With flower of Radix Notoginseng as monarch drug, Fructus Lycii is ministerial drug to this Radix Notoginseng flower composition that the present invention is provided, and Flos Chrysanthemi, Flos Sophorae are adjuvant drug, and it is to make medicine to selectively add Herba Lophatheri, Folium Nelumbinis, Radix Puerariae, Semen Cassiae.Using plurality of Chinese, mutually compatibility is coordinated, ensure good taste and the safety of product, it is to avoid the pained abnormal smells from the patient of medicine, while this Radix Notoginseng flower composition has regulating lipoid and reducing blood pressure, flat liver improving eyesight, phencyclidine, can prevent and nurse one's health diseases of cardiovascular and cerebrovascular systems, adjust metabolism and physiological function, defying age, enhancing human body immunity power.
Description
Technical field
A kind of the present invention relates to field of health care food, more particularly to flower of Radix Notoginseng compositions field.
Background technology
Modern standard of living is improved constantly, and diet structure is but seriously unreasonable, excessively edible fine food, high protein,
High-fat food excess intake, coarse grain eats very few, and the people for suffering from hypertension, hyperlipidemia, diabetes etc. various " affluenza " is more next
More, the crowd for being in sub-health status is also being on the increase.
The health product of application flower of Radix Notoginseng and combinations thereof, food are less in the market, in certain market vacancy shape
State.Radix Notoginseng is certainly《Compendium of Materia Medica》Since including, the history of 500 years is had, Li Shizhen (1518-1593 A.D.) is said：" all state Fan Dong remote mountains of life Nandan County, Guangxi
In, it is suddenly and violently dry to adopt root, yellow black.Unity thing, shape is slightly like Pseudobulbus Bletillae (Rhizoma Bletillae)；The for example old Radix Rehmanniae of elder, has section.Taste micro-sweet and bitter, quite like Radix Ginseng
Taste ".《A Supplement to the Compendium of Materia Medica》Say：" ginseng qi-tonifying first, Radix Notoginseng enriches blood first, is the most precious person of Chinese medicine ".Flower of Radix Notoginseng
For the dry product of araliaceae ginseng plant's Radix Notoginseng inflorescence, it is arasaponin content highest part in Radix Notoginseng Herb, nature and flavor are sweet
Cool, with heat clearing away, suppressing the hyperactive liver, blood pressure lowering, improve myocardial oxygen delivery ability, enhancing human body immunity function.How to be applied to protect by flower of Radix Notoginseng
In health food, and its effect is played, become those skilled in the art and be badly in need of a difficult problem to be solved.
Content of the invention
For solving problem above, the present invention provides a kind of Radix Notoginseng flower composition, it is characterised in that including following component：Radix Notoginseng
Spend 5 ~ 60 parts, 5 ~ 60 parts of Fructus Lycii, 5 ~ 50 parts of Flos Chrysanthemi, 5 ~ 40 parts of Flos Sophorae, 0 ~ 30 part of Herba Lophatheri, 0 ~ 30 part of Folium Nelumbinis, 0 ~ 20 part of Radix Puerariae,
0 ~ 20 part of Semen Cassiae.
Preferably, the flower of Radix Notoginseng, Fructus Lycii, Flos Chrysanthemi, the mass parts of Flos Sophorae are respectively 40 parts, 40 parts, 20 parts and 10 parts.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Starting material with water or 60% ~ 80% ethanol solution are extracted, extracting solution is filtered, is concentrated；
（3）Extracting solution after by concentration is dried, that is, obtain the Radix Notoginseng flower composition.
Preferably, step（2）Described in starting material with water is extracted, by extracting solution filter, concentration specifically refer to, by original
After material soaks 1 hour, heating extraction 1 ~ 3 time, 0.5 ~ 2 hour every time, each amount of water was the 8 ~ 10 of the raw materials quality
Times, by extracting solution merging, filtration, cold preservation, standing, impurity is centrifuged off, is concentrated.
Preferably, step（2）Described raw material is extracted with 60% ~ 80% ethanol solution, by extracting solution filter, concentration tool
Body refers to, plus 60% by raw material ~ 80% alcohol solution dipping is after 1 hour, heating extraction 1 ~ 3 time, 0.5 ~ 2 hour every time, every time plus
60% ~ 80% ethanol solution quality is 6 ~ 8 times of the raw material, extracting solution is filtered, is merged, and stands, filters, and reclaims ethanol, dense
Contracting.
Preferably, the concentration of the ethanol solution is 70%.
Application of the Radix Notoginseng flower composition in medicine, health product or food is prepared.
Preferably, the medicine, health product are granule, tablet, pill, powder, oral liquid or capsule dosage form；Described
Food is alternative tea, beverage, cake or the confection of natural plant shape, graininess or powder.
Preferably, adding one or more in following adjuvant or additive to Radix Notoginseng flower composition：Acidity regulator, anti-
Knot agent, defoamer, binding agent, antioxidant, bleach, bulking agent, coloring agent, colour fixative, enzyme preparation, flavour enhancer, nutrition are strong
Agent, preservative, sweeting agent, thickening agent, spice, are applied to prepare food.
Preferably, adding one or more in following adjuvant to Radix Notoginseng flower composition：Dextrin, stevioside, Sorbitol,
Starch, Mannitol, sodium carboxymethyl cellulose, carboxymethyl starch sodium are prepared into granule, tablet, pill, powder, oral liquid or glue
Wafer dosage form, is applied to prepare medicine, health product；Its Central Plains powder is 1 with cyclodextrin ratios：0.3-1：1.5.
With flower of Radix Notoginseng as monarch, cool in nature, Return liver kidney channel, heat clearing away, suppressing the hyperactive liver drop this Radix Notoginseng flower composition that the present invention is provided
Pressure.With Fructus Lycii as minister, mild-natured enter Liver and kidney, nourishing the liver and kidney, replenishing vital essence to improve eyesight.With Flos Chrysanthemi, Flos Sophorae as assistant, cooling blood for hemostasis, liver heat removing are rushed down
Fire, plays dispersing the stagnated live-QI to relieve the stagnation of QI altogether, adjusts metabolism and physiological function.Herba Lophatheri, Folium Nelumbinis, Radix Puerariae, Semen Cassiae diuresis lipid-loweringing, suppressing the hyperactive liver are bright
Mesh, with it for making medicine, contributes to the normal performance of blood vessels function.Using plurality of Chinese, mutual compatibility is coordinated, and respectively takes the chief, pacifies
Complete effectively, it is ensured that the good taste of product and safety, it is to avoid the pained abnormal smells from the patient of medicine, while this Radix Notoginseng flower composition
There is regulating lipoid and reducing blood pressure, flat liver improving eyesight, phencyclidine can prevent and nurse one's healths diseases of cardiovascular and cerebrovascular systems, adjust metabolism with
Physiological function, defying age, enhancing human body immunity power.The present invention adopts pure natural raw material, raw material to be easy to get, have no toxic side effect.
Specific embodiment
Embodiment one
A kind of Radix Notoginseng flower composition includes following component：40 parts of flower of Radix Notoginseng, 40 parts of Fructus Lycii, 20 parts of Flos Chrysanthemi, 10 parts of Flos Sophorae.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Raw material was soaked after 1 hour, extraction 3 times is boiled, 1 hour every time, each amount of water was 8 times of the raw material
Amount, three extracting solution is merged, is filtered, and 2 DEG C ~ 8 DEG C cold preservations of filtrate stand 24 hours, are centrifuged off impurity with high speed centrifuge,
Relative density is concentrated into for 1.05 ~ 1.10（60 DEG C of surveys）Extractum, be spray-dried, obtain dry extract；
（3）Above-mentioned dry extract and dextrin, stevioside are taken according to 70：29：1 ratio mix homogeneously, by granule routine work
Skill, dry granulation make granule, packaging, sterilizing.
Embodiment two
A kind of Radix Notoginseng flower composition includes following component：40 parts of flower of Radix Notoginseng, 40 parts of Fructus Lycii, 20 parts of Flos Chrysanthemi, 10 parts of Flos Sophorae.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Raw material plus 70%（V/V）After alcohol solution dipping 1 hour, heating extraction 3 times 1 hour every time, adds 70% second every time
Alcoholic solution quality is 6 times of the raw material, extracting solution is filtered, is merged, and stands, filters, and heating recovery ethanol is to without alcohol taste, dense
Relative density is reduced to for 1.05 ~ 1.10（60 DEG C of surveys）Extractum, be spray-dried, obtain dry extract；
（3）Above-mentioned dry extract and dextrin, stevioside are taken according to 64：35：1 ratio mix homogeneously, by granule routine work
Skill, dry granulation make granule, packaging, sterilizing.
Embodiment three
A kind of Radix Notoginseng flower composition, it is characterised in that including following component：40 parts of flower of Radix Notoginseng, 40 parts of Fructus Lycii, 20 parts of Flos Chrysanthemi, Flos Sophorae
10 parts.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）Above-mentioned flower of Radix Notoginseng, Fructus Lycii, Flos Chrysanthemi, Flos Sophorae are picked respectively and picked, smash or is not smashed, dry；
（2）Flower of Radix Notoginseng, Fructus Lycii, Flos Chrysanthemi, Flos Sophorae are weighed by weight；
（3）Pack according to recipe quantity proportioning, sealing.
Be the alternative tea of natural plant shape according to the Radix Notoginseng flower composition obtained by formula, alternative tea is taken when drinking and is put into
In cup, 3～5 minutes are brewed with boiling water.
Example IV
A kind of Radix Notoginseng flower composition, it is characterised in that including following component：5 parts of flower of Radix Notoginseng, 7 parts of Fructus Lycii, 5 parts of Flos Chrysanthemi, Flos Sophorae 5
Part, 2 parts of Herba Lophatheri, 8 parts of Folium Nelumbinis.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Raw material plus 60%（V/V）After alcohol solution dipping 1 hour, heating extraction 3 times 1 hour every time, adds 60% second every time
Alcoholic solution amount is 8 times of the raw material, extracting solution is filtered, is merged, and stands, filters, and heating recovery ethanol is to without alcohol taste, concentration
It is 1.05 ~ 1.10 to relative density（60 DEG C of surveys）Extractum, be spray-dried, obtain dry extract；
（3）Above-mentioned dry extract and flour or rice flour or Semen Glycines powder are taken according to 1:10 ratio is weighed, and adds the mixing such as water, using normal
Rule method makes direct-edible cake after cooking.
Embodiment five
A kind of Radix Notoginseng flower composition, it is characterised in that including following component：25 parts of flower of Radix Notoginseng, 28 parts of Fructus Lycii, 15 parts of Flos Chrysanthemi, Flos Sophorae
10 parts, 20 parts of Folium Nelumbinis, 15 parts of Radix Puerariae, 13 parts of Semen Cassiae.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Raw material was soaked after 1 hour, heating extraction 2 times, 2 hours every time, each amount of water is the 10 of the raw material
Times, extracting solution will merge twice, relative density will be concentrated into for 1.15 ~ 1.25（60 DEG C of surveys）Extractum, add a certain amount of 95% second
Alcohol stands 24 ~ 48 hours, takes supernatant, be centrifuged with tubular type to the precipitate with ethanol solution that solution alcohol content is 60%, mix homogeneously, cold preservation
Machine is centrifuged off impurity, and heating recovery ethanol is extremely without alcohol taste, and is concentrated into relative density for 1.01 ~ 1.10（60 DEG C of surveys）Leaching
Cream；
（3）The conventional correctivess of the oral liquids such as a certain amount of Sorbitol, stevioside and other adjuvants is added in above-mentioned extractum, is mixed
Uniform, fine straining is closed, fill, sterilizing obtain final product oral liquid.
Embodiment six
A kind of Radix Notoginseng flower composition includes following component：60 parts of flower of Radix Notoginseng, 60 parts of Fructus Lycii, 50 parts of Flos Chrysanthemi, 40 parts of Flos Sophorae, Herba Lophatheri
30 parts, 30 parts of Folium Nelumbinis, 20 parts of Radix Puerariae, 20 parts of Semen Cassiae.
The preparation method of this Radix Notoginseng flower composition, comprises the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Raw material plus 80%（V/V）After alcohol solution dipping 1 hour, heating extraction 3 times 0.5 hour every time, plus 80% every time
Ethanol solution amount is 8 times of raw material amounts, extracting solution is filtered, is merged, and stands, filters, heating recovery ethanol to without alcohol taste,
Relative density is concentrated into for 1.05 ~ 1.15（60 DEG C of surveys）Extractum, be spray-dried, obtain dry extract；
（3）Take above-mentioned dry extract and starch, Mannitol, sodium carboxymethyl cellulose（CMC-Na）, carboxymethyl starch sodium（CMS-
Na）Deng adjuvant mix homogeneously according to a certain percentage, by granule, tablet or capsule common process, granule, tablet or glue is made
Capsule.
Pharmacological evaluation：Spontaneous hypertensive rat (SHR) 40 is taken, 4 groups are divided at random：Spontaneously hypertensive group, group 1
(giving the granule of embodiment 1), organizes 2 (giving the granule of embodiment 2), organizes 3 (giving the teabag of embodiment 3), each group
10, male and female half and half；Normal blood pressure rats (WKY) 10, male and female half and half.Dosage and method：WKY matched groups and SHR are empty
White group gives distilled water respectively, and group 1 gives the granule of embodiment 1, and group 2 gives the granule of embodiment 2, and group 3 gives to be implemented
The teabag of example 3；Every rat gives dosage for 10ml/ (kg d), daily 2 times, continuous 8 weeks；Testing index：Rat blood pressure
Measurement, non-invasive tail volume manometry totally 4 times (administration is first 1 time, administration 10 days 1 time, 1 month each 1 time, all at administration end
Extremely front 1 time), take after whole specimen centrifuges supernatant with radioimmunology and Nitrate reductase determine plasma A ngII, ET-1,
CGRP, NO, TXB2,6-keto-PGF1a content.As a result show, take in 3 groups of rats of the product of the present invention, its rat blood pressure is equal
There is decline, have significant difference (P with SHR blank groups<0.05), SHR blank groups blood pressure rises to compare with WKY groups has statistics to anticipate
Justice.
From upper data：
（1）Embodiment one, embodiment two, the product of embodiment three substantially can reduce blood pressure, while reducing blood plasma ET-1 water
Flat, as Level of Plasma ET-1 declines, also decline after NO content in plasma treatment, and to other vasoactive factors without obvious shadow
Ring.
（2）Embodiment one, embodiment two, embodiment three formula all identical, only preparation method is different, but three kinds of systems
Product prepared by Preparation Method all possesses identical effect.
Preferred embodiments of the present invention are these are only, therefore the scope of present invention enforcement can not be limited according to this, i.e., according to the present invention
Equivalence changes and decoration that description is made, should all belong in the range of present invention covering.
Claims (10)
1. a kind of Radix Notoginseng flower composition, it is characterised in that including following component：In terms of mass parts, 5 ~ 60 parts of flower of Radix Notoginseng, Fructus Lycii 5 ~
60 parts, 5 ~ 50 parts of Flos Chrysanthemi, 5 ~ 40 parts of Flos Sophorae, 0 ~ 30 part of Herba Lophatheri, 0 ~ 30 part of Folium Nelumbinis, 0 ~ 20 part of Radix Puerariae, 0 ~ 20 part of Semen Cassiae.
2. according to a kind of Radix Notoginseng flower composition described in claim 1, it is characterised in that the flower of Radix Notoginseng, Fructus Lycii, Flos Chrysanthemi, Chinese scholartree
Colored mass parts are respectively 40 parts, 40 parts, 20 parts and 10 parts.
3. the preparation method of Radix Notoginseng flower composition as claimed in claim 1 or 2, it is characterised in that comprise the following steps：
（1）According to each component raw material that formula weighs corresponding deal；
（2）Starting material with water or 60% ~ 80% ethanol solution are extracted, extracting solution is filtered, is concentrated；
（3）Extracting solution after by concentration is dried, that is, obtain the Radix Notoginseng flower composition.
4. the preparation method of Radix Notoginseng flower composition according to claim 3, it is characterised in that step（2）Described by starting material with water
Extracted, extracting solution filtration, concentration are specifically referred to, raw material was soaked after 1 hour, heating extraction 1 ~ 3 time, every time
0.5 ~ 2 hour, each amount of water was 8 ~ 10 times of the raw materials quality, and extracting solution merging, filtration, cold preservation, standing, centrifugation are removed
Decontamination, concentration.
5. according to the preparation method of Radix Notoginseng flower composition described in claim 3, it is characterised in that step（2）Described raw material is used
60% ~ 80% ethanol solution is extracted, and extracting solution filtration, concentration is specifically referred to, plus 60% ~ 80% alcohol solution dipping by raw material
After 1 hour, heating extraction 1 ~ 3 time, 0.5 ~ 2 hour every time, plus 60% every time ~ 80% ethanol solution quality is the 6 ~ 8 of the raw material
Times, extracting solution is filtered, is merged, stood, filter, reclaim ethanol, concentration.
6. the preparation method of Radix Notoginseng flower composition according to claim 5, it is characterised in that the concentration of the ethanol solution is
70%.
7. application of the Radix Notoginseng flower composition as claimed in claim 1 or 2 in medicine, health product or food is prepared.
8. application as claimed in claim 7, it is characterised in that the medicine, health product be granule, tablet, pill, dissipate
Agent, oral liquid or capsule dosage form；The food is the alternative tea of natural plant shape, graininess or powder, beverage, cake
Or confection.
9. application as claimed in claim 8, it is characterised in that add in following adjuvant or additive to Radix Notoginseng flower composition
One or more：Acidity regulator, anticaking agents, defoamer, binding agent, antioxidant, bleach, bulking agent, coloring agent, color fixative
Agent, enzyme preparation, flavour enhancer, nutrition enhancer, preservative, sweeting agent, thickening agent, spice, are applied to prepare food.
10. application as claimed in claim 8, it is characterised in that add the one kind or many in following adjuvant to Radix Notoginseng flower composition
Kind：Dextrin, stevioside, Sorbitol, starch, Mannitol, sodium carboxymethyl cellulose, carboxymethyl starch sodium be prepared into granule,
Tablet, pill, powder, oral liquid or capsule dosage form, are applied to prepare medicine, health product；Its Central Plains powder with cyclodextrin ratios is
1：0.3-1：1.5.
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