CN107115460A - David's-harp compound granules and preparation method thereof - Google Patents
David's-harp compound granules and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/482—Cassia, e.g. golden shower tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/734—Crataegus (hawthorn)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
A kind of David's-harp compound granules, it is made up of David's-harp, lotus leaf, the fruit of Chinese wolfberry, hawthorn, cassia seed ratio by weight, is mixed through water extraction and alcohol extracting.Present invention employs the unique concocting method of David's-harp medicinal material 4321 and the crushing of compound classification of medicinal material, functional component classification extractive technique, compound extract yield and functional component content are high, and Antilipemic health effect is particularly evident.Show through third party small white mouse lipid-loweringing experiment, David's-harp compound granules have identical lipid-lowering effect with Chinese medicine Jiangzhi Ling, Western medicine Simvastatin, serum cholesterol, serum levels of triglyceride and serum LDL cholesterol level can be significantly reduced, while serum High Density Lipoprotein Cholesterol level can be improved.The product has effects that nourishing liver and kidney, reduction blood fat, and Product quality and safety is reliable, has no side effect, can take in right amount for a long time.
Description
Technical field
The present invention relates to food processing technology field, more particularly to a kind of David's-harp compound granules and preparation method thereof.
Background technology
The dry rhizome of high liliaceous plant David's-harp (Polygonatum cyrtonema Hua.) is that Chinese medicine is yellow
One of former plant of essence.Chinese medicinal material merchandising is recorded, and David's-harp is the fine work of sealwort.Traditional Chinese Medicine thinks, sealwort is sweet,
Mild-natured, returns spleen, lung, kidney channel with tonifying Qi, moistening lung, invigorating the spleen, strong kidney, black hair, fill out the functions such as marrow, defaecation, are strengthening by means of tonics medicine.
Modern scientific research shows that sealwort principle active component is polysaccharide, steroid saponin, flavones, alkaloid etc., is made with anti-aging
Harden, improve and improve memory with, hypoglycemic, reducing blood lipid, anti-dynamic athero- arteries and veins, it is antitumor, antiviral.Sealwort and its preparation are available
In treatment coronary heart disease, hyperlipemia, diabetes, low blood pressure, drug poisoning deafness, leukopenia, chronic glomerulus kidney
The various disease conditions such as inflammation, chronic bronchitis, ishemic stroke.
At present, the domestic patent of invention on sealwort is concentrated mainly on health liquor, tissue-cultured seedling, blood lipid-reducing blood sugar-decreasing composition, drink
Material etc..Such as, patent of invention " Chinese medicine composition of blood lipid-reducing blood sugar-decreasing and its application " (201410227770X), its formula is：The sophora bud 25
6~8 parts of~35 parts, 10~20 parts of STEVIA REBAUDIANA, 5~15 parts of sealwort and Cassia occidentalis.The country is not also using reducing blood lipid as major function
David's-harp compound granules product and preparation method.
The content of the invention
To solve the problem of above-mentioned prior art is present, the present invention provides one kind with David's-harp, lotus leaf, hawthorn, Cassia
The food granules that son, matrimony vine five tastes integration of drinking and medicinal herbs medicinal material compound dry extract are made.The electuary is using exclusive formula, medicinal material processing side
Method, high efficiency compound extract extractive technique, are formed, the main work(with reducing blood lipid and filling liver kidney through modern production process is refined
Effect.
The present invention solves the technical scheme that its technical problem is used：This David's-harp compound granules, it is by following original
Material proportioning is made：Fresh 8 parts~36 parts of David's-harp, 1.5 parts~8 parts of lotus leaf, 1.5 parts~5 parts of the fruit of Chinese wolfberry, hawthorn 3 parts~9
Part, 1 part~3 parts of cassia seed, wherein fresh David's-harp turns into dry David's-harp after processing, fresh David's-harp spends more Huang with dry
The ratio of essence is 3.5~5.5:1, lotus leaf: dry David's-harp=1: 1~1.5, cassia seed: hawthorn=1: 2~3.
2nd, David's-harp compound granules according to claim 1, it is made up of following raw materials according proportioning：David's-harp
24 parts, 6 parts of lotus leaf, 3 parts of the fruit of Chinese wolfberry, 6 parts of hawthorn, 2 parts of cassia seed, wherein fresh David's-harp turns into after processing dry spends more Huang
The ratio of essence, fresh David's-harp and dry David's-harp is 4:1, lotus leaf: dry David's-harp=1: 1, cassia seed: hawthorn=1:
3。。
The preparation method of above-mentioned David's-harp compound granules, comprises the following steps：
The first step, medicinal material select, by medicinal material weight ratio weigh respectively David's-harp, lotus leaf, cassia seed, the fruit of Chinese wolfberry,
Hawthorn, David's-harp selects new fresh quench stem, it is desirable to which rhizome is sturdy, section is faint yellow, eat sweetness raw is more than without bitter taste, single fresh weight
50g, lotus leaf, cassia seed, the fruit of Chinese wolfberry, hawthorn select to meet the dry medicinal material of NF standard；
Second step, David's-harp processes, and using 4321 concocting methods, first cleans David's-harp rhizome, is cut into length
Spend for the block of 2~3 centimeter lengths, then David's-harp rhizome is placed in 80~100kpa of operating pressure pressure cooker for the first time plus
Heat 4 hours of wet steaming, heat in 50 DEG C~60 DEG C environment is placed in after taking-up and is dried 50~60 minutes, while pressure cooker continues to heat water
Be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；Second of 3 hour of wet steaming under identical operating pressure, it is placed in 50
DEG C~60 DEG C of environment in dry 50~60 minutes, while pressure cooker continue heat water is condensed into the ring that medicinal extract shape is stored in 0~5 DEG C
Border is standby；Third time 2 hours of wet steaming under identical operating pressure, be placed in after taking-up in 50 DEG C~60 DEG C environment heat dry 50~
60 minutes, at the same pressure cooker continue heat by water be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；4th time identical
Operating pressure under 1 hour of wet steaming, pour into the pot for holding sealwort water after the airing of rhizome surface, heat while stirring, until
Moisture content evaporating completely in pot, rhizome dry tack free, taking-up, which is placed in 50 DEG C~60 DEG C environment, dries 8~12 hours, wherein sealwort water
It is to weigh drinking water in the ratio of David's-harp dry rhizome weight 1~5%, the medicinal extract of first time to third time is poured into water
Mix thoroughly obtained；
3rd step, medicinal material drying, the David's-harp polyoses content ＞ 30% after processing, water content≤8%, lotus leaf, Cassia
Son, the fruit of Chinese wolfberry, hawthorn quality press NF, water content≤8%；
4th step, medicinal material flour, five kinds of medicinal materials be divided into two classes crush, first kind medicinal material be David's-harp and the fruit of Chinese wolfberry,
Co-grinding is into 0.1~1mm of particle diameter coarse powder, and Equations of The Second Kind medicinal material is lotus leaf, cassia seed, hawthorn, is first cut into before lotus leaf mixing wide by 2
~3 centimetres, long 10~20 centimetres bar shaped fragment, coarse powder of the co-grinding into 0.1~1mm of particle diameter；
The David's-harp of first kind medicinal material and the fruit of Chinese wolfberry are carried out Polyose extraction, method is as follows by the 5th step, water extraction polysaccharide：
A1, medicinal material is decocted：David's-harp and matrimony vine are mixed into coarse powder to immerse in the drinking water of 8~10 times of its weight, soaked
15~30 minutes, 110~180 DEG C of high-temperature boilings under reflux technique, then boiled 120~180 minutes with 90~100 DEG C of temperature, collect
Water extract；
A2, medical filtration, water extract is made decoction be separated with the dregs of a decoction, is obtained water using filtering accuracy≤0.1mm filters filtering
Carry decoction；
A3, decoction concentration, water extraction decoction is boiled at a temperature of 110~180 DEG C, and glue is cooked at a temperature of 90~100 DEG C,
The water extracted immersing paste is obtained, the low temperature drying environment for being stored in 0~5 DEG C is standby；
(6) ferment carries Nuciferine, the dry medicinal material lotus leaf of Equations of The Second Kind medicinal material, cassia seed, hawthorn is extracted, method is as follows：
B1, medicinal material is decocted：By lotus leaf, cassia seed, hawthorn mix coarse powder immerse 8~10 times of its weight, concentration for 75~
In 95% ethanol, soak 15~30 minutes, 78~100 DEG C of temperature extractions 120~180 minutes under reflux technique are collected ferment and carried
Thing；
B2, medical filtration, ferment extract is made decoction be separated with the dregs of a decoction, is obtained ferment using filtering accuracy≤0.1mm filters filtering
Carry decoction；
B3, decoction concentration, ferment carries decoction and is cooked into glue at a temperature of 80~100 DEG C, obtains alcohol-extracted extract, be hidden in 0~5 DEG C
Low temperature drying environment is standby；
7th step, medicinal extract combination drying：Water extraction immersion cream and alcohol extracting immersion cream are taken out, mixing, plus its weight 1~10%
Drinking water, after stirring, be placed in 50~70 DEG C of insulating boxs and dry to constant weight, then be ground into diameter 180um
Dry extract, vacuum packaging, sealing storage, obtain David's-harp compound granules.
In the present invention, David's-harp processes in step 2, also referred to as 4321 concocting methods, when referring to wet steaming
Between, it can repeatedly be quenched by the step and refine David's-harp, at utmost remain the Siberian solomonseal rhizome polysaccharide content in David's-harp medicinal material,
The present invention is according to the tcm health preserving theory that Diet cures more than the doctors, and five kinds of medicinal materials needed for medicinal material formula are all as defined in health ministry
" integration of drinking and medicinal herbs " Chinese medicine, and medicinal material collocation and ratio control reasonable, science, have given full play to nourishing liver and kidney, reduction blood fat
Effect, Antilipemic health effect is particularly evident, and the present invention uses David's-harp for the 4321 unique concocting methods and medicine of main ingredient
Material classification is crushed, functional component classification extractive technique, and compound extract interest rate and functional component content are high, are dropped through third party small white mouse
Fat tests table, and David's-harp compound granules have identical lipid-lowering effect with Chinese medicine Jiangzhi Ling, Western medicine Simvastatin, can significantly dropped
Low serum cholesterol, serum levels of triglyceride and serum LDL cholesterol level, while serum high-density fat can be improved
Protein cholesterol level.Product quality and safety reliably has no side effect, and can take in right amount for a long time, reflux technique refers to extraction field
Interior reflux technique.
In the present invention, David's-harp and lotus leaf are all monarch drug in a prescription, in order to play effect of its kidney tonifying and reducing blood lipid, are aided with mountain
Short, bristly hair or beard, three kinds of adjuvants of cassia seed and matrimony vine.David's-harp has effects that yin-nourishing, tonifying Qi, kidney-nourishing, and lotus leaf has the administration's dampness elimination that disappears, liter
The clear sun of hair, the effect of cooling blood and hemostasis, recent studies confirms that Siberian solomonseal rhizome polysaccharide and Nuciferine have preferable reducing blood lipid, norcholesterol
With the effect of fat-reducing.The fruit of Chinese wolfberry strengthens the effect that monarch drug in a prescription is nourishing liver and kidney, nourish the liver to improve visual acuity；Science is matched somebody with somebody in proportion for cassia seed and hawthorn
5, effect of monarch drug in a prescription reducing blood lipid, kidney-nourishing, stomach invigorating is improved, while having in formula except wet, wind-damp dispelling the lotus leaf of administration and Cassia
Son, overcome again David's-harp grow it is greasy help wet disadvantage, after their mutual compatibilities, liver-kidney tonifying, effect of nourishing blood for improving eyesight are highlighted,
High fat of blood and graying of hair phenomenon caused by reduction kidney deficiency and liver can be significantly improved.
The hyperlipemic patients of Lishui eight voluntarily take compound Polygonatum electuary 30 days, compound are taken before sleeping daily yellow
15 grams of fine agent, continuously takes 30 days, compared with before taking, and all patient's cholesterol and glycerine have obvious reduction, the range of decrease
50.3~35.6%.
Research report ZYS20170110~0503 that Zhejiang Research Institute of Traditional Chinese Medicine Co., Ltd. provides, with Chinese medicine Jiangzhi Ling
Be positive control with Western medicine Simvastatin, investigate compound David's-harp electuary 30g crude drugs/kg, 15g crude drug/kg and 7.5g crude drugs/
Kg dosage is low to high blood lipid model rat blood serum cholesterol, serum levels of triglyceride, serum High Density Lipoprotein Cholesterol and serum
The influence of density lipoprotein-cholesterol level.As a result show, compound David's-harp electuary 30g crude drugs/kg, 15g crude drug/kg can show
Reduction serum cholesterol, serum levels of triglyceride and serum LDL cholesterol level are write, while it is highly dense to improve serum
Spend lipoprotein cholesterol level.Compound David's-harp electuary has notable lipid-lowering effect.
The each group rat blood serum cholesterol of table 1 is compared (LSD inspections) with model group
The each group rat blood serum triglyceride of table 2 is compared (LSD inspections) with model group
The each group rat blood serum hdl level of table 3 is compared (LSD inspections) with model group
The each group rat blood serum low-density lipoprotein white level of table 4 is compared (LSD inspections) with model group
The invention has the advantages that：
First, the present invention is according to the tcm health preserving theory that Diet cures more than the doctors, and five kinds of medicinal materials needed for medicinal material formula are all country
Integration of drinking and medicinal herbs Chinese medicine as defined in the Ministry of Public Health, and medicinal material collocation and ratio control rationally, science, given full play to it is nourishing liver and kidney,
Effect of blood fat is reduced, Product quality and safety is reliable, has no side effect；
2nd, the present invention uses David's-harp for the 4321 unique concocting methods and classification of medicinal material crushing, effect of main ingredient
Compositional classification is extracted, and compound extract interest rate and functional component content are high, it is ensured that the quality of David's-harp compound granules and health care
Effect；
3rd, David's-harp compound granules of the present invention through the lipid-loweringing of third party small white mouse test, with Chinese medicine Jiangzhi Ling and west
Medicine Simvastatin identical lipid-lowering effect, can significantly reduce serum cholesterol, serum levels of triglyceride and serum low-density LP
Cholesterol levels, while serum High Density Lipoprotein Cholesterol level can be improved, substantially, Product quality and safety is reliable for lipid-lowering effect
Have no side effect, can take in right amount for a long time.
Embodiment
The invention will be further described below：
Embodiment one：
This David's-harp compound granules, it is made up of following raw materials according proportioning：The fresh ㎏ of David's-harp 8, the ㎏ of lotus leaf 2,
The ㎏ of the fruit of Chinese wolfberry 1.5, the ㎏ of hawthorn 3, the ㎏ of cassia seed 1, wherein fresh David's-harp turns into dry David's-harp after processing, it is fresh to spend more Huang
The smart ratio with dry David's-harp is 4:1, lotus leaf: dry David's-harp=1: 1, cassia seed: hawthorn=1: 3.
The preparation method of above-mentioned David's-harp compound granules, comprises the following steps：
The first step, medicinal material select, by medicinal material weight ratio weigh respectively David's-harp, lotus leaf, cassia seed, the fruit of Chinese wolfberry,
Hawthorn, David's-harp selects new fresh quench stem, it is desirable to which rhizome is sturdy, section is faint yellow, eat sweetness raw is more than without bitter taste, single fresh weight
50g, lotus leaf, cassia seed, the fruit of Chinese wolfberry, hawthorn select to meet the dry medicinal material of NF standard；
Second step, David's-harp processes, and using 4321 concocting methods, first cleans David's-harp rhizome, is cut into length
Spend for the block of 2~3 centimeter lengths, then David's-harp rhizome is placed in 80~100kpa of operating pressure pressure cooker for the first time plus
Heat 4 hours of wet steaming, heat in 50 DEG C~60 DEG C environment is placed in after taking-up and is dried 50~60 minutes, while pressure cooker continues to heat water
Be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；Second of 3 hour of wet steaming under identical operating pressure, it is placed in 50
DEG C~60 DEG C of environment in dry 50~60 minutes, while pressure cooker continue heat water is condensed into the ring that medicinal extract shape is stored in 0~5 DEG C
Border is standby；Third time 2 hours of wet steaming under identical operating pressure, be placed in after taking-up in 50 DEG C~60 DEG C environment heat dry 50~
60 minutes, at the same pressure cooker continue heat by water be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；4th time identical
Operating pressure under 1 hour of wet steaming, pour into the pot for holding sealwort water after the airing of rhizome surface, heat while stirring, until
Moisture content evaporating completely in pot, rhizome dry tack free, taking-up, which is placed in 50 DEG C~60 DEG C environment, dries 8~12 hours, wherein sealwort water
It is to weigh drinking water in the ratio of David's-harp dry rhizome weight 1~5%, the medicinal extract of first time to third time is poured into water
Mix thoroughly obtained；
3rd step, medicinal material drying, the David's-harp polyoses content ＞ 30% after processing, water content≤8%, lotus leaf, Cassia
Son, the fruit of Chinese wolfberry, hawthorn quality press NF, water content≤8%；
4th step, medicinal material flour, five kinds of medicinal materials be divided into two classes crush, first kind medicinal material be David's-harp and the fruit of Chinese wolfberry,
Co-grinding is into 0.1~1mm of particle diameter coarse powder, and Equations of The Second Kind medicinal material is lotus leaf, cassia seed, hawthorn, is first cut into before lotus leaf mixing wide by 2
~3 centimetres, long 10~20 centimetres bar shaped fragment, coarse powder of the co-grinding into 0.1~1mm of particle diameter；
The David's-harp of first kind medicinal material and the fruit of Chinese wolfberry are carried out Polyose extraction, method is as follows by the 5th step, water extraction polysaccharide：
A1, medicinal material is decocted：David's-harp and matrimony vine are mixed into coarse powder to immerse in the drinking water of 8~10 times of its weight, soaked
15~30 minutes, 110~180 DEG C of high-temperature boilings under reflux technique, then boiled 120~180 minutes with 90~100 DEG C of temperature, collect
Water extract；
A2, medical filtration, water extract is made decoction be separated with the dregs of a decoction, is obtained water using filtering accuracy≤0.1mm filters filtering
Carry decoction；
A3, decoction concentration, water extraction decoction is boiled at a temperature of 110~180 DEG C, and glue is cooked at a temperature of 90~100 DEG C,
The water extracted immersing paste is obtained, the low temperature drying environment for being stored in 0~5 DEG C is standby；
(6) ferment carries Nuciferine, the dry medicinal material lotus leaf of Equations of The Second Kind medicinal material, cassia seed, hawthorn is extracted, method is as follows：
B1, medicinal material is decocted：By lotus leaf, cassia seed, hawthorn mix coarse powder immerse 8~10 times of its weight, concentration for 75~
In 95% ethanol, soak 15~30 minutes, 78~100 DEG C of temperature extractions 120~180 minutes under reflux technique are collected ferment and carried
Thing；
B2, medical filtration, ferment extract is made decoction be separated with the dregs of a decoction, is obtained ferment using filtering accuracy≤0.1mm filters filtering
Carry decoction；
B3, decoction concentration, ferment carries decoction and is cooked into glue at a temperature of 80~100 DEG C, obtains alcohol-extracted extract, be hidden in 0~5 DEG C
Low temperature drying environment is standby；
7th step, medicinal extract combination drying：By water extraction immersion cream and the taking-up of alcohol extracting immersion cream, the drink of mixing, plus its weight 1%
With water, after stirring, it is placed in 50~70 DEG C of insulating boxs and dries to constant weight, then is ground into the dry of diameter 180um
Extract powder, vacuum packaging, sealing storage obtains David's-harp compound granules.
Embodiment two：
This David's-harp compound granules, it is made up of following raw materials according proportioning：The fresh ㎏ of David's-harp 24, the ㎏ of lotus leaf 6,
The ㎏ of the fruit of Chinese wolfberry 3, the ㎏ of hawthorn 6, the ㎏ of cassia seed 2, wherein fresh David's-harp turns into dry David's-harp, fresh David's-harp after processing
Ratio with dry David's-harp is 4:1, lotus leaf: dry David's-harp=1: 1, cassia seed: hawthorn=1: 3.
The preparation method of above-mentioned David's-harp compound granules, comprises the following steps：
The first step, medicinal material select, by medicinal material weight ratio weigh respectively David's-harp, lotus leaf, cassia seed, the fruit of Chinese wolfberry,
Hawthorn, David's-harp selects new fresh quench stem, it is desirable to which rhizome is sturdy, section is faint yellow, eat sweetness raw is more than without bitter taste, single fresh weight
50g, lotus leaf, cassia seed, the fruit of Chinese wolfberry, hawthorn select to meet the dry medicinal material of NF standard；
Second step, David's-harp processes, and using 4321 concocting methods, first cleans David's-harp rhizome, is cut into length
Spend for the block of 2~3 centimeter lengths, then David's-harp rhizome is placed in 80~100kpa of operating pressure pressure cooker for the first time plus
Heat 4 hours of wet steaming, heat in 50 DEG C~60 DEG C environment is placed in after taking-up and is dried 50~60 minutes, while pressure cooker continues to heat water
Be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；Second of 3 hour of wet steaming under identical operating pressure, it is placed in 50
DEG C~60 DEG C of environment in dry 50~60 minutes, while pressure cooker continue heat water is condensed into the ring that medicinal extract shape is stored in 0~5 DEG C
Border is standby；Third time 2 hours of wet steaming under identical operating pressure, be placed in after taking-up in 50 DEG C~60 DEG C environment heat dry 50~
60 minutes, at the same pressure cooker continue heat by water be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；4th time identical
Operating pressure under 1 hour of wet steaming, pour into the pot for holding sealwort water after the airing of rhizome surface, heat while stirring, until
Moisture content evaporating completely in pot, rhizome dry tack free, taking-up, which is placed in 50 DEG C~60 DEG C environment, dries 8~12 hours, wherein sealwort water
It is to weigh drinking water in the ratio of David's-harp dry rhizome weight 1~5%, the medicinal extract of first time to third time is poured into water
Mix thoroughly obtained；
3rd step, medicinal material drying, the David's-harp polyoses content ＞ 30% after processing, water content≤8%, lotus leaf, Cassia
Son, the fruit of Chinese wolfberry, hawthorn quality press NF, water content≤8%；
4th step, medicinal material flour, five kinds of medicinal materials be divided into two classes crush, first kind medicinal material be David's-harp and the fruit of Chinese wolfberry,
Co-grinding is into 0.1~1mm of particle diameter coarse powder, and Equations of The Second Kind medicinal material is lotus leaf, cassia seed, hawthorn, is first cut into before lotus leaf mixing wide by 2
~3 centimetres, long 10~20 centimetres bar shaped fragment, coarse powder of the co-grinding into 0.1~1mm of particle diameter；
The David's-harp of first kind medicinal material and the fruit of Chinese wolfberry are carried out Polyose extraction, method is as follows by the 5th step, water extraction polysaccharide：
A1, medicinal material is decocted：David's-harp and matrimony vine are mixed into coarse powder to immerse in the drinking water of 8~10 times of its weight, soaked
15~30 minutes, 110~180 DEG C of high-temperature boilings under reflux technique, then boiled 120~180 minutes with 90~100 DEG C of temperature, collect
Water extract；
A2, medical filtration, water extract is made decoction be separated with the dregs of a decoction, is obtained water using filtering accuracy≤0.1mm filters filtering
Carry decoction；
A3, decoction concentration, water extraction decoction is boiled at a temperature of 110~180 DEG C, and glue is cooked at a temperature of 90~100 DEG C,
The water extracted immersing paste is obtained, the low temperature drying environment for being stored in 0~5 DEG C is standby；
(6) ferment carries Nuciferine, the dry medicinal material lotus leaf of Equations of The Second Kind medicinal material, cassia seed, hawthorn is extracted, method is as follows：
B1, medicinal material is decocted：By lotus leaf, cassia seed, hawthorn mix coarse powder immerse 8~10 times of its weight, concentration for 75~
In 95% ethanol, soak 15~30 minutes, 78~100 DEG C of temperature extractions 120~180 minutes under reflux technique are collected ferment and carried
Thing；
B2, medical filtration, ferment extract is made decoction be separated with the dregs of a decoction, is obtained ferment using filtering accuracy≤0.1mm filters filtering
Carry decoction；
B3, decoction concentration, ferment carries decoction and is cooked into glue at a temperature of 80~100 DEG C, obtains alcohol-extracted extract, be hidden in 0~5 DEG C
Low temperature drying environment is standby；
7th step, medicinal extract combination drying：By water extraction immersion cream and the taking-up of alcohol extracting immersion cream, the drink of mixing, plus its weight 5%
With water, after stirring, it is placed in 50~70 DEG C of insulating boxs and dries to constant weight, then is ground into the dry of diameter 180um
Extract powder, vacuum packaging, sealing storage obtains David's-harp compound granules.
Embodiment three：
This David's-harp compound granules, it is made up of following raw materials according proportioning：The fresh ㎏ of David's-harp 35, the ㎏ of lotus leaf 7,
The ㎏ of the fruit of Chinese wolfberry 5, the ㎏ of hawthorn 4, the ㎏ of cassia seed 2, wherein fresh David's-harp turns into dry David's-harp, fresh David's-harp after processing
Ratio with dry David's-harp is 5:1, lotus leaf: dry David's-harp=1: 1, cassia seed: hawthorn=1: 2.
The preparation method of above-mentioned David's-harp compound granules, comprises the following steps：
The first step, medicinal material select, by medicinal material weight ratio weigh respectively David's-harp, lotus leaf, cassia seed, the fruit of Chinese wolfberry,
Hawthorn, David's-harp selects new fresh quench stem, it is desirable to which rhizome is sturdy, section is faint yellow, eat sweetness raw is more than without bitter taste, single fresh weight
50g, lotus leaf, cassia seed, the fruit of Chinese wolfberry, hawthorn select to meet the dry medicinal material of NF standard；
Second step, David's-harp processes, and using 4321 concocting methods, first cleans David's-harp rhizome, is cut into length
Spend for the block of 2~3 centimeter lengths, then David's-harp rhizome is placed in 80~100kpa of operating pressure pressure cooker for the first time plus
Heat 4 hours of wet steaming, heat in 50 DEG C~60 DEG C environment is placed in after taking-up and is dried 50~60 minutes, while pressure cooker continues to heat water
Be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；Second of 3 hour of wet steaming under identical operating pressure, it is placed in 50
DEG C~60 DEG C of environment in dry 50~60 minutes, while pressure cooker continue heat water is condensed into the ring that medicinal extract shape is stored in 0~5 DEG C
Border is standby；Third time 2 hours of wet steaming under identical operating pressure, be placed in after taking-up in 50 DEG C~60 DEG C environment heat dry 50~
60 minutes, at the same pressure cooker continue heat by water be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；4th time identical
Operating pressure under 1 hour of wet steaming, pour into the pot for holding sealwort water after the airing of rhizome surface, heat while stirring, until
Moisture content evaporating completely in pot, rhizome dry tack free, taking-up, which is placed in 50 DEG C~60 DEG C environment, dries 8~12 hours, wherein sealwort water
It is to weigh drinking water in the ratio of David's-harp dry rhizome weight 1~5%, the medicinal extract of first time to third time is poured into water
Mix thoroughly obtained；
3rd step, medicinal material drying, the David's-harp polyoses content ＞ 30% after processing, water content≤8%, lotus leaf, Cassia
Son, the fruit of Chinese wolfberry, hawthorn quality press NF, water content≤8%；
4th step, medicinal material flour, five kinds of medicinal materials be divided into two classes crush, first kind medicinal material be David's-harp and the fruit of Chinese wolfberry,
Co-grinding is into 0.1~1mm of particle diameter coarse powder, and Equations of The Second Kind medicinal material is lotus leaf, cassia seed, hawthorn, is first cut into before lotus leaf mixing wide by 2
~3 centimetres, long 10~20 centimetres bar shaped fragment, coarse powder of the co-grinding into 0.1~1mm of particle diameter；
The David's-harp of first kind medicinal material and the fruit of Chinese wolfberry are carried out Polyose extraction, method is as follows by the 5th step, water extraction polysaccharide：
A1, medicinal material is decocted：David's-harp and matrimony vine are mixed into coarse powder to immerse in the drinking water of 8~10 times of its weight, soaked
15~30 minutes, 110~180 DEG C of high-temperature boilings under reflux technique, then boiled 120~180 minutes with 90~100 DEG C of temperature, collect
Water extract；
A2, medical filtration, water extract is made decoction be separated with the dregs of a decoction, is obtained water using filtering accuracy≤0.1mm filters filtering
Carry decoction；
A3, decoction concentration, water extraction decoction is boiled at a temperature of 110~180 DEG C, and glue is cooked at a temperature of 90~100 DEG C,
The water extracted immersing paste is obtained, the low temperature drying environment for being stored in 0~5 DEG C is standby；
(6) ferment carries Nuciferine, the dry medicinal material lotus leaf of Equations of The Second Kind medicinal material, cassia seed, hawthorn is extracted, method is as follows：
B1, medicinal material is decocted：By lotus leaf, cassia seed, hawthorn mix coarse powder immerse 8~10 times of its weight, concentration for 75~
In 95% ethanol, soak 15~30 minutes, 78~100 DEG C of temperature extractions 120~180 minutes under reflux technique are collected ferment and carried
Thing；
B2, medical filtration, ferment extract is made decoction be separated with the dregs of a decoction, is obtained ferment using filtering accuracy≤0.1mm filters filtering
Carry decoction；
B3, decoction concentration, ferment carries decoction and is cooked into glue at a temperature of 80~100 DEG C, obtains alcohol-extracted extract, be hidden in 0~5 DEG C
Low temperature drying environment is standby；
7th step, medicinal extract combination drying：Water extraction immersion cream and alcohol extracting immersion cream are taken out, mixing, plus its weight 10%
Drinking water, after stirring, is placed in 50~70 DEG C of insulating boxs and dries to constant weight, then be ground into diameter 180um's
Dry extract, vacuum packaging, sealing storage obtains David's-harp compound granules.
The characteristics of embodiment of the present invention is：
First, the present invention is according to the tcm health preserving theory that Diet cures more than the doctors, and five kinds of medicinal materials needed for medicinal material formula are all country
Integration of drinking and medicinal herbs Chinese medicine as defined in the Ministry of Public Health, and medicinal material collocation and ratio control rationally, science, given full play to it is nourishing liver and kidney,
Effect of blood fat is reduced, Product quality and safety is reliable, has no side effect；
2nd, the present invention uses David's-harp for the 4321 unique concocting methods and classification of medicinal material crushing, effect of main ingredient
Compositional classification extractive technique, compound extract yield and functional component content are high, it is ensured that David's-harp compound granules quality and guarantor
Strong effect；
3rd, David's-harp compound granules of the present invention through the lipid-loweringing of third party small white mouse test, with Chinese medicine Jiangzhi Ling and west
Medicine Simvastatin identical lipid-lowering effect, can significantly reduce serum cholesterol, serum levels of triglyceride and serum low-density LP
Cholesterol levels, while serum High Density Lipoprotein Cholesterol level can be improved, lipid-lowering effect substantially, can be taken in right amount for a long time.
Although the present invention is described by reference to preferred embodiment, those skilled in the art should
Work as understanding, in the range of claims, various change in form and details can be made.
Claims (3)
1. a kind of David's-harp compound granules, it is characterised in that it is made up of following raw materials according proportioning：Fresh 8 parts of David's-harp
~36 parts, 1.5 parts~8 parts of lotus leaf, 1.5 parts~5 parts of the fruit of Chinese wolfberry, 3 parts~9 parts of hawthorn, 1 part~3 parts of cassia seed, wherein fresh many
As dry David's-harp after flower sealwort processing, the ratio of fresh David's-harp and dry David's-harp is 3.5~5.5:1, lotus leaf: dry
David's-harp=1: 1~1.5, cassia seed: hawthorn=1: 2~3.
2. David's-harp compound granules according to claim 1, it is characterised in that it is made up of following raw materials according proportioning：
24 parts of David's-harp, 6 parts of lotus leaf, 3 parts of the fruit of Chinese wolfberry, 6 parts of hawthorn, 2 parts of cassia seed, wherein fresh David's-harp turns into dry after processing
The ratio of David's-harp, fresh David's-harp and dry David's-harp is 4:1, lotus leaf: dry David's-harp=1: 1, cassia seed: hawthorn
=1: 3.
3. the preparation method of David's-harp compound granules according to claim 1 or 2, it is characterised in that including following step
Suddenly：
(1) medicinal material is selected, and is weighed David's-harp, lotus leaf, cassia seed, the fruit of Chinese wolfberry, hawthorn respectively by medicinal material part by weight, is spent more Huang
It is selected to select new fresh quench stem, it is desirable to rhizome is sturdy, section is faint yellow, eat raw it is sweet be more than 50g without bitter taste, single fresh weight, lotus leaf, certainly
Pine torch, the fruit of Chinese wolfberry, hawthorn select to meet the dry medicinal material of NF standard；
(2) David's-harp processes, and using " 4321 " concocting method, first cleans David's-harp rhizome, be cut into length for 2~
David's-harp rhizome, is then placed in 80~100kpa of operating pressure pressure cooker and heats wet steaming 4 by the block of 3 centimeter lengths for the first time
Heat in 50 DEG C~60 DEG C environment is placed in after individual hour, taking-up to dry 50~60 minutes, is condensed into water while pressure cooker continues to heat
The environment that medicinal extract shape is stored in 0~5 DEG C is standby；Second of 3 hour of wet steaming under identical operating pressure, it is placed in 50 DEG C~60
Dried 50~60 minutes in DEG C environment, at the same pressure cooker continue to heat by water be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby
With；Third time 2 hours of wet steaming under identical operating pressure, heat in 50 DEG C~60 DEG C environment is placed in after taking-up and dries 50~60 points
Clock, at the same pressure cooker continue heat by water be condensed into medicinal extract shape be stored in 0~5 DEG C environment it is standby；4th time in identical work
It is wet under pressure to steam 1 hour, pour into the pot for holding sealwort water, heat while stirring after the rhizome surface airing such as taking-up, until
Moisture content evaporating completely in pot, rhizome dry tack free, taking-up, which is placed in 50 DEG C~60 DEG C environment, dries 8~12 hours, wherein sealwort water
It is to weigh drinking water in the ratio of David's-harp dry rhizome weight 1~5%, the medicinal extract of first time to third time is poured into water
Mix thoroughly obtained；
(3) medicinal material is dried, the David's-harp polyoses content ＞ 30% after processing, water content≤8%, lotus leaf, cassia seed, matrimony vine
Son, hawthorn quality press NF, water content≤8%；
(4) five kinds of medicinal materials, are divided into two classes and crushed, first kind medicinal material is David's-harp and the fruit of Chinese wolfberry, co-grinding by medicinal material flour
Into 0.1~1mm of particle diameter coarse powder, Equations of The Second Kind medicinal material is lotus leaf, cassia seed, hawthorn, be first cut into before lotus leaf mixing it is wide 2~3 centimetres,
Long 10~20 centimetres bar shaped fragment, coarse powder of the co-grinding into 0.1~1mm of particle diameter；
(5) water extraction polysaccharide, carries out Polyose extraction, method is as follows by the David's-harp of first kind medicinal material and the fruit of Chinese wolfberry：
A1, medicinal material is decocted：David's-harp and matrimony vine are mixed into coarse powder to immerse in the drinking water of 8~10 times of its weight, immersion 15~
30 minutes, 110~180 DEG C of high-temperature boilings under reflux technique, then boiled 120~180 minutes with 90~100 DEG C of temperature, collect water extraction
Thing；
A2, medical filtration, water extract is made decoction be separated with the dregs of a decoction, is obtained water extraction medicine using filtering accuracy≤0.1mm filters filtering
Liquid；
A3, decoction concentration, water extraction decoction boils at a temperature of 110~180 DEG C, is cooked into glue at a temperature of 90~100 DEG C, obtains water
Extracted extract, the low temperature drying environment for being stored in 0~5 DEG C is standby；
(6) ferment carries Nuciferine, the dry medicinal material lotus leaf of Equations of The Second Kind medicinal material, cassia seed, hawthorn is extracted, method is as follows：
B1, medicinal material is decocted：It is 75~95% that lotus leaf, cassia seed, hawthorn, which are mixed coarse powder to immerse 8~10 times of its weight, concentration,
In ethanol, soak 15~30 minutes, 78~100 DEG C of temperature extractions 120~180 minutes under reflux technique collect ferment extract；
B2, medical filtration, ferment extract is made decoction be separated with the dregs of a decoction, is obtained ferment and carry medicine using filtering accuracy≤0.1mm filters filtering
Liquid；
B3, decoction concentration, ferment carries decoction and is cooked into glue at a temperature of 80~100 DEG C, obtains alcohol-extracted extract, be hidden in 0~5 DEG C of low temperature
Dry environment is standby；
(7) medicinal extract combination drying：Water extraction immersion cream and alcohol extracting immersion cream are taken out, mixing, plus its weight 1~10% is drunk
Water, after stirring, is placed in 50~70 DEG C of insulating boxs and dries to constant weight, then be ground into diameter 180um dry leaching
Cream powder, vacuum packaging, sealing storage obtains David's-harp compound granules.
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