CN104126786B - A kind of health product improving high glucose and high fat and preparation method thereof - Google Patents
A kind of health product improving high glucose and high fat and preparation method thereof Download PDFInfo
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- CN104126786B CN104126786B CN201310155216.0A CN201310155216A CN104126786B CN 104126786 B CN104126786 B CN 104126786B CN 201310155216 A CN201310155216 A CN 201310155216A CN 104126786 B CN104126786 B CN 104126786B
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- Prior art keywords
- extract
- tartary buckwheat
- fructus mori
- colouring agent
- red colouring
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- 230000036541 health Effects 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 title claims abstract description 6
- 239000008103 glucose Substances 0.000 title claims abstract description 6
- 239000000284 extract Substances 0.000 claims abstract description 78
- 239000000843 powder Substances 0.000 claims abstract description 49
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 48
- 244000130270 Fagopyrum tataricum Species 0.000 claims abstract description 40
- 235000014693 Fagopyrum tataricum Nutrition 0.000 claims abstract description 40
- 238000004040 coloring Methods 0.000 claims abstract description 35
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- 238000002156 mixing Methods 0.000 claims abstract description 15
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- 239000000706 filtrate Substances 0.000 claims description 18
- 238000000034 method Methods 0.000 claims description 15
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 6
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- 230000000694 effects Effects 0.000 abstract description 9
- PCZOHLXUXFIOCF-UHFFFAOYSA-N Monacolin X Natural products C12C(OC(=O)C(C)CC)CC(C)C=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 PCZOHLXUXFIOCF-UHFFFAOYSA-N 0.000 abstract description 7
- PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract description 7
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- 239000002671 adjuvant Substances 0.000 abstract description 2
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- 150000001413 amino acids Chemical class 0.000 abstract 1
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- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
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- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Mycology (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a kind of height fat health product sugared, high improving diabetics and preparation method thereof, it includes steps such as Hongqu powder (red colouring agent), tartary buckwheat extract, the mixing of Fructus Mori extract, dry, pulverizing；Preparation method of the present invention is simple, in formula, in the lovastatin in Hongqu powder (red colouring agent), tartary buckwheat extract, the composition such as the deoxynojirimycin in total flavones, Fructus Mori and several amino acids can suppress or reduce blood glucose, blood fat, this formula, by three kinds of raw material use in conjunction, enhances effect of blood sugar lowering, blood fat reducing.It addition, the Hongqu powder (red colouring agent) of present invention offer, tartary buckwheat extract, Fructus Mori extract mixtures can add pharmaceutically acceptable adjuvant as raw material or auxiliary element makes tablet, capsule, granule or granular tea etc., there is huge medicinal, health care and be worth.
Description
Technical field
The present invention relates to technical field of health care food, be specifically related to a kind of height fat health care formula sugared, high improving patient and
Preparation method.
Background technology
Compendium of Material Medica is recorded: Radix Et Rhizoma Fagopyri Tatarici nature and flavor are bitter, flat, cold, and " real the intestines and stomach, physical strength profiting, continuous spirit, profit knowledge, can practice five
Dirty dregs is dirty ", " sending down the abnormal ascending QI width intestinal, mill is stagnant, the heat that disappears swollen wind pain.Traditional medicine and modern medicine all confirm Radix Et Rhizoma Fagopyri Tatarici have blood sugar lowering,
Blood fat reducing, urine glucose lowering, anti-constipation, defying age, resisting fatigue, antioxidation, the effect such as anticancer, be referred to as " three fall food " by authoritative expert
" health food of the 21 century mankind ".These all with Radix Et Rhizoma Fagopyri Tatarici in contain bioflavonoids, vitamin, trace element and
The nutritional labelings such as mineral are relevant.Flavone in Radix Et Rhizoma Fagopyri Tatarici has heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, improves microcirculation, removing toxic substances and promoting tissue regeneration etc.
Biological effect, therefore total flavones can also be as the important indicator evaluating Radix Et Rhizoma Fagopyri Tatarici and products thereof quality.
The Compendium of Material Medica of bright Li Shizhen (1518-1593 A.D.) and " the little knowledge of physics " of FANG Yi-zhi are all related to the record of Monas cuspurpureus Went manufacture method.
Described in Compendium of Material Medica: Monas cuspurpureus Went cures mainly to help digestion and invigorates blood circulation, spleen and stomach dry, control dysentery with red and white feces, Xia Shuigu.Wine brewing, removing blood stasis row medicine gesture, kill
Epidemic pathogenic factors from mountains, controls to beat and flutters trauma.
Modern study finds that it has potent component for reducing blood fat Monacolin K (i.e. Lovastatin, lovastatin).Red
Song is inoculated in, by Monascus fungus, the rice fermentation cooked and forms, and our province is the main product ground of China's Monas cuspurpureus Went, with Gutian Monas cuspurpureus Went is
Write.Monascus has 6 kinds, traditionally hyoscine be mostly Mauve aspergillar (Monascus purpureus Went).
Fructus Mori are the dry fruit ear of moraceae plants Mulberry Morus albaL., have another name called sorosis, and before more than 2,000 years, Fructus Mori are
It it is the hired tonic of Chinese emperors." Bencao Jingshu " is mentioned: " Fructus Mori, sweet cold benefit blood heat extraction, the medicine of tonifying YIN of enriching blood for removing heat from blood ".
And Compendium of Material Medica meaning " is smash juice drink, is solved alcohol intoxication;Wine brewing clothes, diuretic gas, detumescence ".The growing environment special because of mulberry makes sorosis
There is spontaneous growth, without the feature of any pollution, so Fructus Mori are otherwise known as " holy fruit among the people ".
Due to rhythm of life accelerate, dietary habit bad, suffer from hyperglycemia, the number of hyperlipidemia has the trend of growth, and
Present rural area and low age crowd's sickness rate have greatly improved relatively former years, prolonged administration of drugs, can make people produce drug resistance and
More toxic and side effects, therefore needs on market a kind of to reduce blood glucose, blood fat, being conveniently easy to get of blood pressure, low cost, secondary make
The health food having both with little food and medicine.
Summary of the invention
The goal of the invention of the present invention is to provide a kind of height fat health care formula sugared, high improving diabetics and preparation side
Method, the method by Hongqu powder (red colouring agent), tartary buckwheat extract and Fructus Mori extract being mixed, being vacuum dried, the step such as pulverizing, former by three kinds
Material use in conjunction, enhances effect of blood sugar lowering, blood fat reducing.
Present invention also offers the mixture of the Hongqu powder (red colouring agent), tartary buckwheat extract and the Fructus Mori that are prepared by said method, by
Tartary buckwheat extract 1～5 parts and Hongqu powder (red colouring agent) 1～3 parts and Fructus Mori extract 0.1～5 parts of compositions.
The invention provides the application in medicine, health product preparation of the mixture of Hongqu powder (red colouring agent), tartary buckwheat extract and Fructus Mori.
In order to reach foregoing invention purpose, the technical solution used in the present invention is: provides a kind of and improves diabetics
The preparation method of high fat health care formula sugared, high, is characterized in that, comprise the following steps:
A, carry out steaming enzyme denaturing by Radix Et Rhizoma Fagopyri Tatarici；
B, Radix Et Rhizoma Fagopyri Tatarici after enzyme denaturing add the water of 6～15 times of Radix Et Rhizoma Fagopyri Tatarici weight, extract 2～4 times at 70～100 DEG C,
Extraction time is 30～120 minutes every time, united extraction liquid, filters, and filtrate is concentrated into relative density at 50～100 DEG C and is
1.02～1.15, prepare concentrated solution A；
C, toward concentrated solution A adds volumetric concentration be 90～98% ethanol to ethanol volumetric concentration in solution reach 60～
90%, then stand 6～48 hours at 0～20 DEG C, filter, prepare filtrate；
D, by step c prepare filtrate recycling ethanol, be then concentrated at 60～90 DEG C relative density be 1.15～
1.30, prepare concentrated solution；By concentrated solution at 60～90 DEG C of drying under reduced pressure, pulverize, prepare water-soluble tartary buckwheat general flavone extract；
E, tartary buckwheat extract is mixed in proportion with Hongqu powder (red colouring agent)；
F, take the mixed powder of tartary buckwheat extract and Hongqu powder (red colouring agent), add Fructus Mori extract, mix homogeneously, be then prepared as being dried
Thing；
G, step f is obtained dried object pulverize, prepare Hongqu powder (red colouring agent), tartary buckwheat extract, the mixture of Fructus Mori.
The preparation method of Fructus Mori extract is to take mulberry fruit to add 2-8 times of water, extracts, adds 70%-90% ethanol, and it is heavy to filter
Forming sediment, filtrate is spray-dried after concentrating or high speed centrifugation drying machine is dried.
The described enzyme denaturing that steams, uses 0.4-0.6MP high steam to steam 30-120 minute.
Described medicine, the dosage form of health product can be tablet, capsule, granule or granular tea.
Described medicine is combined, by Hongqu powder (red colouring agent), tartary buckwheat extract and the mixture of Fructus Mori, starch and dextrin, the granule made
Agent.
Described medicine is by Hongqu powder (red colouring agent), tartary buckwheat extract and the mixture of Fructus Mori, dextrin, magnesium stearate and carboxymethyl starch
Sodium combines the tablet made.
Described medicine is combined, by Hongqu powder (red colouring agent), tartary buckwheat extract and the mixed powder of Fructus Mori, maltodextrin, the capsule made.
Described health product are combined, by Hongqu powder (red colouring agent), tartary buckwheat extract and the mixture of Fructus Mori, Radix Et Rhizoma Fagopyri Tatarici powder, the granular tea made.
In sum, the preparation method of a kind of height fat health care formula sugared, high improving diabetics that the present invention provides,
The method by Hongqu powder (red colouring agent), tartary buckwheat extract and Fructus Mori extract being mixed, being vacuum dried, the step such as pulverizing, by three kinds of raw materials
Use in conjunction, enhances effect of blood sugar lowering, blood fat reducing.Mixing of Hongqu powder (red colouring agent), tartary buckwheat extract and the Fructus Mori extract that the present invention provides
Compound can add pharmaceutically acceptable adjuvant as raw material or auxiliary element make tablet, capsule, granule or granular tea
Deng, medicinal, the health care with preferable blood sugar lowering, blood fat reducing and blood pressure lowering, and instant edible, peace is proved by test
Good perfection, life-time service has no side effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the detailed description of the invention of the present invention is described in detail, although combine and be embodied as
The detailed description of the invention of the present invention is described in detail by example, but is not the restriction to this patent protection domain.In power
In profit claim limited range, various amendments that those skilled in the art can make without creative work or adjustment
Still it is protected by this patent.
Embodiment 1
Weighing the Radix Et Rhizoma Fagopyri Tatarici 20kg that Sichuan Liangshan Mountain Areas produces, 120 DEG C of high pressure steam 120 minutes, take out, add 6 times amount water and exist
70 DEG C are extracted 2 times, and each 30 minutes, united extraction liquid, filtration, it was 1.02 that filtrate is concentrated into relative density at 50 DEG C, prepares
Concentrated solution A；In concentrated solution A, add the ethanol that volumetric concentration is 90% reach 60% to ethanol volumetric concentration in solution, then at 4 DEG C
Stand 6 hours, filter, prepare filtrate；By filtrate recycling ethanol, being then concentrated into relative density at 60 DEG C is 1.15, prepares
Concentrated solution B；By concentrated solution B at 60 DEG C of drying under reduced pressure, pulverize, prepare 0.96kg buff powder, be water-soluble tartary buckwheat total
Flavone extract；Using colorimetric determination, water solublity general flavone content reaches 39%；Employing high performance liquid chromatography detects, and rutin contains
Amount reaches 21.2%.The preparation method of Fructus Mori extract is to take Fructus Mori dry fruit to add 4 times of water, heating extraction 2 times, filters, and filtrate adds
70% ethanol, filters precipitation, and filtrate is spray dried to dry powder after concentrating.
Weigh tartary buckwheat extract 0.25kg, add 0.75kg Hongqu powder (red colouring agent) (buying from Rong Kang bio tech ltd, Shaanxi)
Mix homogeneously, then mix homogeneously with the Fructus Mori extract of 0.25kg, it is vacuum dried 6 hours at 80 DEG C, takes out, control ambient humidity
When 50%, pulverize, prepare 1.56kg aubergine powder, be Hongqu powder (red colouring agent), tartary buckwheat extract and the mixture of Fructus Mori extract；
Using colorimetric determination, general flavone content reaches 6.4%；Employing high performance liquid chromatography detects, and lovastatin content reaches 0.96%.
The mixture of above-mentioned prepared Hongqu powder (red colouring agent), tartary buckwheat extract and Fructus Mori extract will add 8kg starch and 2kg paste
Essence, mixing, use oscillating granulator to be pelletized by 16 eye mesh screens；Granule is put in hot air drier and be dried to containing at 80 DEG C
The water yield is 5%, takes out, lets cool, screen out qualified granule packaging and become 8g/ bag.
Embodiment 2
Take 150KG Radix Et Rhizoma Fagopyri Tatarici high steam enzyme denaturing, boiling three times, extract every time and be separately added into positive sky, Beijing Cheng Cheng
Clear Technology Co., Ltd. ZTC 1+1 clarifier pretreating agent A(presses the 2 ‰ of crude drug), filter, filtrate reduced in volume is to crude drug content
For 2.0g crude drug/ml, concentrated solution is heated to temperature and rises to about 60 DEG C, adds ZTC 1+1 clarifier pretreating agent B(Yu ZTC 1
+ 1 clarifier pretreating agent A equivalent) mixing, insulation 6h boils 20min, is cooled to the ZTC 1+1 clarifier of about 80 DEG C of additions 4%
III B component, mixing, it is incubated 30min, adds clarifier III component A of 2%, mixing, heated and boiled 1 hour.Letting cool, room temperature stands
Overnight.Filter paper filtering (or high speed centrifugation), filtrate reduced in volume, it is dried under vacuum to dry extract, beats powder, both obtain tartary buckwheat extract.
Remarks: the detection of general flavone content is with reference to the mensuration of general flavone content in NYT 1295-2007 Semen Fagopyri Esculenti and goods thereof.
In sum, Radix Et Rhizoma Fagopyri Tatarici is after clarifier technique, and paste-forming rate, the total flavones rate of transform are all improved.And it is right
Finished product character is without impact.
Weigh tartary buckwheat extract 0.75kg, add 0.75kg Hongqu powder (red colouring agent) (buying from Rong Kang bio tech ltd, Shaanxi)
Mix homogeneously, then mix homogeneously with the Fructus Mori extract of 0.5kg, it is vacuum dried 3 hours at 70 DEG C, takes out, control ambient humidity
When 60%, pulverize, prepare 1.74kg aubergine powder, be Hongqu powder (red colouring agent), tartary buckwheat extract and the mixture of Fructus Mori extract；
Using colorimetric determination, general flavone content reaches 17%；Employing high performance liquid chromatography detects, and lovastatin content reaches 0.86%.
By in the mixture of above-mentioned prepared Hongqu powder (red colouring agent), tartary buckwheat extract and Fructus Mori extract add 1.01kg dextrin,
0.1kg magnesium stearate, 0.15kg carboxymethyl starch sodium, mixing, pelletize, be dried, be pressed into 10000.
Embodiment 3
Take 150KG Radix Et Rhizoma Fagopyri Tatarici high steam enzyme denaturing, boiling three times, extract every time and be separately added into positive sky, Beijing Cheng Cheng
Clear Technology Co., Ltd. ZTC 1+1 clarifier pretreating agent A(presses the 2 ‰ of crude drug), filter, filtrate reduced in volume is to crude drug content
For 0.5g crude drug/ml, concentrated solution is heated to temperature and rises to about 60 DEG C, adds ZTC 1+1 clarifier pretreating agent B(Yu ZTC 1
+ 1 clarifier pretreating agent A equivalent) mixing, insulation 4h boils 20min, is cooled to the ZTC 1+1 clarifier of about 80 DEG C of additions 4%
III B component, mixing, it is incubated 30min, adds clarifier III component A of 2%, mixing, heated and boiled 1 hour.Letting cool, room temperature stands
Overnight.Filter paper filtering (or high speed centrifugation), filtrate reduced in volume, it is dried under vacuum to dry extract, beats powder, both obtain tartary buckwheat extract.
Weigh tartary buckwheat extract 1kg, add 0.25kg Hongqu powder (red colouring agent) (buying from Rong Kang bio tech ltd, Shaanxi) and mix
Close uniformly, then mix homogeneously with the Fructus Mori extract of 0.14kg, be vacuum dried 2 hours at 60 DEG C, take out, control ambient humidity and exist
When 45%, pulverize, prepare 1.32kg aubergine powder, be Hongqu powder (red colouring agent), tartary buckwheat extract and the mixture of Fructus Mori extract；Adopt
With colorimetric determination, general flavone content reaches 30%；Employing high performance liquid chromatography detects, and lovastatin content reaches 0.38%.
The mixture of above-mentioned prepared Hongqu powder (red colouring agent), tartary buckwheat extract and Fructus Mori extract will add the Radix Et Rhizoma Fagopyri Tatarici powder of 2.2kg,
Mixing, pelletizes, and 60 DEG C are dried to water content is 5%, and 180 DEG C are toasted 1 hour, take out, let cool, screen out qualified granule packaging
Become the granular health tea of 8g/ bag.
Embodiment 4
This research with rat for experimentation object, with reference to Ministry of Public Health issue " function of health food assessment process with
The method of inspection " method of auxiliary lipid-lowering function experiment regulation, verify further the auxiliary effect for reducing blood fat of this compound preparation.
1 material
1.1 medicines and reagent Radix Et Rhizoma Fagopyri Tatarici Monas cuspurpureus Went Fructus Mori granule (preparing according to embodiment 2 method), human body recommended dose is
16g/d(8g/ bag, every day 2 bags).XUEZHIKANG JIAONANG (Beijing WBL Peking University Biotech Co., Ltd；Specification: 0.3g/ grain),
Human body recommended dose is 1.2g/d.Serum TC, TG test kit (Shanghai revive the Long March medical science company limited)；High density
(David Weightman biotechnology (Nanjing) has for lipoproteins-C (HDL-C), LDL-C (LDL-C) test kit
Limit company).
1.2 key instrument SELECTRA-E full automatic biochemical apparatus (Holland's prestige figure), Microcl17 microcentrifuge
(U.S. Thermo), XHF-D interior cut refiner (NingBo XinZhi Biology Science Co., Ltd), KQY79-1 magnetic
Power heating stirrer (Ke Xi Instrument Ltd. of Jintan City), LP123 electronic balance, JY10001 electronic balance.
1.3 Experimental Animals Male SD rats, body weight 178～205g, is 20～23 DEG C, relative humidity in temperature
It is that the barrier system of 40%～60% is raised.
2 methods
After 60 SD male rats of 2.1 packets and administration feed 5d with normal diet adaptability, weigh, take tail
Blood, surveys serum TC, the basic value of TG, HDL-C, is then randomly divided into 6 groups according to basis TC level: negative control group,
Model group, XUEZHIKANG JIAONANG group, positive controls (prepare Radix Et Rhizoma Fagopyri Tatarici Monas cuspurpureus Went granule according to embodiment 2 method, tartary buckwheat extract and red
The ratio of bent powder is 1:3) and according to the Radix Et Rhizoma Fagopyri Tatarici Monas cuspurpureus Went Fructus Mori granule of embodiment 2 and 3 preparation, often group 10.Negative control group is fed
Raise normal diet, remaining respectively organize feed high lipid food (68.8% normal diet, 1% cholesterol, 10% yolk powder, 10% Adeps Sus domestica, 10%
Sucrose and 0.2% cholate), continuous 30d.Being administered 1 time in every morning, during experiment, each group rat freely ingests, drinks water.
After 2.2 Indexs measure feed 30d continuously, weigh, take big rathole blood system do not detect serum TC, TG, HDL-C,
LDL-C content.
The 2.3 all data of data analysis all use SPSS 15.0 software to carry out statistical procedures, and data mean ±
Standard deviation (x ± s) represents.Measurement data first uses homogeneity test of variance, and P ＞ 0.05 selects t to check, P≤0.05
Select correction t inspection.P ＜ 0.05 is that difference is statistically significant.
3 results
Rat body weight is affected in experimentation by 3.1, Normal group, model control group, positive controls and each reality
Executing example group rat fur glossy, flexibly, appetite and stool are normal in action.Before and after each group rat experiment, body weight and weightening finish are shown in Table
1。
From table 1, before experiment, negative control group, positive controls and each dosage group are compared with model control group, body
Heavily there was no significant difference.Experiment end, negative control group body weight and weight gain are significantly lower than model control group (P ＜ 0.01).
Table 1
3.2 impact experiment end blood sampling mensuration serum TG, TC, HDL-C and LDL-C content on rat fat, real
Test and the results are shown in Table 2, table 3, table 4.
Table 2
From table 2, the T-CHOL of experiment end negative control group, positive controls and embodiment group is significantly lower than mould
Type matched group, and there is significant difference, embodiment group T-CHOL is less than positive controls, has significant difference.
Table 3
From table 3, the triglyceride of experiment end negative control group, positive controls and embodiment group is significantly lower than mould
Type matched group, and there is significant difference.Embodiment group T-CHOL is less than positive controls, has significant difference.
Table 4
Be can see that by table 4, the HDL-C testing last each dosage group compares with model control group, all
There was no significant difference, negative control group, positive controls, the low-density lipoprotein cholesterol of embodiment group are significantly lower than model pair
According to group, and there is significant difference.Experimental data prompting Radix Et Rhizoma Fagopyri Tatarici Monas cuspurpureus Went Fructus Mori granule has significant effect for reducing blood fat, and its effect is excellent
In Radix Et Rhizoma Fagopyri Tatarici Monas cuspurpureus Went granule.
From above-mentioned experiment it can be seen that the product that the present invention provides can well reduce blood pressure and blood lipoid, and the side of preparation
Method uniqueness can well retain the effect of the effective ingredient of Radix Et Rhizoma Fagopyri Tatarici, Monas cuspurpureus Went and Fructus Mori, and simple and easy to do, and cost is relatively low, work
Industry waste water and gas is few.
Claims (5)
1. the health product improving high glucose and high fat, it is characterised in that described health product are to be carried by the Radix Et Rhizoma Fagopyri Tatarici that weight portion is 3 parts
Take thing, the Hongqu powder (red colouring agent) of 3 parts and the Fructus Mori extract composition of 2 parts, described health product are realized by below scheme:
A, by Radix Et Rhizoma Fagopyri Tatarici high steam enzyme denaturing, boiling 3 times, extract 2 ‰ addition positive skies, Beijing one-tenth press crude drug respectively every time
Clarification technique company limited ZTC1+1 clarifier pretreating agent A, filters, and filtrate reduced in volume to crude drug content is 2.0g/ml, dense
Contracting liquid is heated to 60 DEG C, adds the pretreating agent B mixing with ZTC1+1 clarifier pretreating agent A equivalent, and insulation 6h boils
20min, is cooled to ZTC1+1 III B component of 80 DEG C of additions 4%, mixing, is incubated 30min, adds ZTC1+1 III component A of 2%, mixed
Even, heated and boiled 1 hour, let cool, room temperature stands overnight, filter paper filtering or high speed centrifugation, and filtrate reduced in volume is dried under vacuum to
Dry extract, beats powder, has both obtained tartary buckwheat extract；
B, tartary buckwheat extract is mixed in proportion with Hongqu powder (red colouring agent)；
C, take the mixed powder of tartary buckwheat extract and Hongqu powder (red colouring agent), add Fructus Mori extract, mix homogeneously is little 70 DEG C of vacuum drying 3
Time, then it is prepared as dried object；
D, step c is obtained dried object pulverize when ambient humidity 60%, prepare Hongqu powder (red colouring agent), tartary buckwheat extract, Fructus Mori extract
Compositions.
2. the health product improving high glucose and high fat, it is characterised in that described health product are to be carried by the Radix Et Rhizoma Fagopyri Tatarici that weight portion is 4 parts
Take thing, the Hongqu powder (red colouring agent) of 1 part and the Fructus Mori extract composition of 0.56 part, described health product are realized by below scheme:
A, by Radix Et Rhizoma Fagopyri Tatarici high steam enzyme denaturing, boiling 3 times, extract 2 ‰ addition positive skies, Beijing one-tenth press crude drug respectively every time
Clarification technique company limited ZTC1+1 clarifier pretreating agent A, filters, and filtrate reduced in volume to crude drug content is 0.5g/ml, dense
Contracting liquid is heated to 60 DEG C, adds the pretreating agent B mixing with ZTC1+1 clarifier pretreating agent A equivalent, and insulation 4h boils
20min, is cooled to ZTC1+1 III B component of 80 DEG C of additions 4%, mixing, is incubated 30min, adds ZTC1+1 III component A of 2%, mixed
Even, heated and boiled 1 hour, let cool, room temperature stands overnight, filter paper filtering or high speed centrifugation, and filtrate reduced in volume is dried under vacuum to
Dry extract, beats powder, has both obtained tartary buckwheat extract；
B, tartary buckwheat extract is mixed in proportion with Hongqu powder (red colouring agent)；
C, take the mixed powder of tartary buckwheat extract and Hongqu powder (red colouring agent), add Fructus Mori extract, mix homogeneously is little 60 DEG C of vacuum drying 2
Time, then it is prepared as dried object；
D, step c is obtained dried object pulverize when ambient humidity 45%, prepare Hongqu powder (red colouring agent), tartary buckwheat extract, Fructus Mori extract
Compositions.
Health product the most according to claim 1 and 2, it is characterised in that the preparation side of the Fructus Mori extract described in step c
Method is to take mulberry fruit to add 2-8 times of water, extracts, adds 70%-90% ethanol, filters precipitation, and filtrate is dried after concentrating, drying means
For be spray-dried or high speed centrifugation is dried or lyophilization.
Health product the most according to claim 1, it is characterised in that the dosage form of described health product is tablet, described tablet
Composition weight portion is Hongqu powder (red colouring agent) 3 parts, tartary buckwheat extract 3 parts, Fructus Mori extract 2 parts, 4.04 parts of dextrin, magnesium stearate 0.4 part, carboxylic
0.6 part of methyl starch sodium.
Health product the most according to claim 2, it is characterised in that the dosage form of described health product is granular tea, described
The composition weight portion of grain tea is Hongqu powder (red colouring agent) 1 part, tartary buckwheat extract 4 parts, Fructus Mori extract 0.56 part, Radix Et Rhizoma Fagopyri Tatarici powder 8.8 parts.
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| CN102641343A (en) * | 2012-05-05 | 2012-08-22 | 耿福能 | Water-soluble tartary buckwheat general flavone extract and preparation method and application thereof |
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| CN101380398A (en) * | 2008-09-09 | 2009-03-11 | 毛晓敏 | Composition for prevention and treatment of cardio-cerebrolvascular disease |
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