CN102641343A - Water-soluble tartary buckwheat general flavone extract and preparation method and application thereof - Google Patents
Water-soluble tartary buckwheat general flavone extract and preparation method and application thereof Download PDFInfo
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- CN102641343A CN102641343A CN2012101364379A CN201210136437A CN102641343A CN 102641343 A CN102641343 A CN 102641343A CN 2012101364379 A CN2012101364379 A CN 2012101364379A CN 201210136437 A CN201210136437 A CN 201210136437A CN 102641343 A CN102641343 A CN 102641343A
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- fagopyri tatarici
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Abstract
The invention discloses a preparation method of a water-soluble tartary buckwheat general flavone extract, which comprises the following steps: steaming, enzyme removing, water extracting, alcohol extracting, drying and the like. The preparation method is simple and high in extraction rate. Prepared general flavone extract can be completely solved in water to be utilized by a human body to give full play to the power effect to the largest extent. In addition, the water-soluble tartary buckwheat general flavone extract can serve as a raw material, and auxiliary materials or auxiliary components which are acceptable in pharmacy can be added into the extract to prepare tablet agents, capsules, soft capsules, oral liquid, dropping pills, nebulas, granules or injection liquid and other medicaments, so that the extract has huge medicinal value.
Description
Technical field
The present invention relates to food technology field, be specifically related to a kind of method for preparing of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone.
Background technology
Compendium of Material Medica record: the Radix Et Rhizoma Fagopyri Tatarici nature and flavor are bitter, flat, cold, " real the intestines and stomach, physical strength profiting, continuous spirit, sharp knowledge, it is dirty to practice the five internal organs dregs ", " the wide intestinal of sending down the abnormal ascending QI, mill is stagnant, and the heat that disappears swells wind bitterly.Traditional medicine and modern medicine confirm that all Radix Et Rhizoma Fagopyri Tatarici has blood sugar lowering, blood fat reducing, urine glucose lowering, anti-constipation, defying age, resisting fatigue, antioxidation, effect such as anticancer, is called " three fall food " and " 21 century human beings'health food " by the authoritative expert.These all with Radix Et Rhizoma Fagopyri Tatarici in the nutritional labelings such as bioflavonoids, vitamin, trace element and mineral that contain relevant.Flavone in the Radix Et Rhizoma Fagopyri Tatarici has biological effects such as heat-clearing and toxic substances removing, blood circulation promoting and blood stasis dispelling, microcirculation improvement, removing toxic substances and promoting tissue regeneration, hypoglycemic; Its main component is a 2-phenyl chromone compounds; Like Flavonoid substances such as rutin, Quercetin, kaempferol and morins; Wherein, rutin content is the highest, accounts for about 85% of general flavone content.Research shows that the content of content of total flavone and rutin has certain positive correlation, so the content of rutin can reflect content of total flavone effectively.
Scientific research and clinical trial prove: rutin can be used as medicine, like the compound rutin sheet; Can be used as health product again.Rutin has the effect of Citrin appearance, can reduce capillary permeability and fragility, microcirculation improvement; Promote hyperplasia and the effect of aspects such as prevent to stop blooding cell condensation and antiinflammatory, antiallergic, diuresis, spasmolytic, antitussive, blood fat reducing, anti peroxidation of lipid, defying age, anticancer antiviral.Therefore rutin also can be used as the important indicator of estimating Radix Et Rhizoma Fagopyri Tatarici and beverage quality thereof.
According to bibliographical information, contain a kind of rutin hydrolase in the Radix Et Rhizoma Fagopyri Tatarici, add at room temperature under the condition of water and can rutin be hydrolyzed to Quercetin, glucose and rhamnose.Quercetin is the aglycon of rutin, has the biological activity similar with rutin, have preferably eliminate the phlegm, cough-relieving, relieving asthma, antiinflammatory, antioxidation, antitumor action; Theoretically; Rutin content reduces in the Radix Et Rhizoma Fagopyri Tatarici, and the increase of quercetin content still makes Radix Et Rhizoma Fagopyri Tatarici have the physiological function of Flavonoid substances, but Quercetin is water-soluble hardly; Be difficult to when therefore the Radix Et Rhizoma Fagopyri Tatarici goods use water as solvent Quercetin is extracted, Flavonoid substances can't be by the human body utilization.
The Radix Et Rhizoma Fagopyri Tatarici goods of present stage are to adopt Radix Et Rhizoma Fagopyri Tatarici powder or Radix Et Rhizoma Fagopyri Tatarici directly to process mostly, and this method rutin in forming process is become Quercetin by enzymolysis, greatly reduces the utilization rate of effective ingredient in the Radix Et Rhizoma Fagopyri Tatarici finished product; Aspect drinking, more present Radix Et Rhizoma Fagopyri Tatarici goods adopt to soak and drink, and effective ingredient stripping is fully utilized by human body.
Summary of the invention
The technical problem that the present invention will solve is: the deficiency that is directed to prior art; A kind of method for preparing of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone is provided; This method steams the rutin hydrolase that knocks out in the Radix Et Rhizoma Fagopyri Tatarici through high temperature, carries out technologies such as water is put forward, alcohol extraction, drying again, makes that water solublity total flavones main component rutin is extracted effectively in the Radix Et Rhizoma Fagopyri Tatarici; Thereby make the water solublity extractive of general flavone, be convenient to human body absorbing this extract.
Another technical problem that the present invention will solve has provided the water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone that is got by method for preparing.
Another technical problem that the present invention will solve has provided the application of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone in medication preparation.
In order to reach the foregoing invention purpose, the technical scheme that the present invention adopts is: a kind of method for preparing of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone is provided, it is characterized in that, may further comprise the steps:
A, Radix Et Rhizoma Fagopyri Tatarici is steamed enzyme denaturing;
The water that adds 6～15 times of Radix Et Rhizoma Fagopyri Tatarici weight in b, the Radix Et Rhizoma Fagopyri Tatarici behind enzyme denaturing extracts 2～4 times at 70～100 ℃, and each extraction time is 30～120 minutes; Merge extractive liquid; Filter, filtrating is concentrated into relative density under 50～100 ℃ be 1.02～1.15, makes concentrated solution A;
C, to add volumetric concentration in the concentrated solution A be that the ethanol volumetric concentration reaches 60～90% in 90～98% ethanol to the solution, left standstill 6～48 hours at 0～20 ℃ then, filters, and makes filtrating;
D, with the filtrate recycling ethanol that step c makes, under 60～90 ℃, being concentrated into relative density then is 1.15～1.30, makes concentrated solution B; Concentrated solution B at 60～90 ℃ of drying under reduced pressure, is pulverized, make water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone.
In the steps A, the condition that steams enzyme denaturing is to steam 5～120 minutes down at 100～150 ℃, and the enzyme that is gone out is a rutin hydrolase.
The dosage form of said medicine can be tablet, capsule, soft capsule, oral liquid, drop pill, spray, granule or injection.
Said medicine is the granule of being processed by water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone, lactose and mannitol combination.
Said medicine is the tablet of being processed by water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone, starch, magnesium stearate and carboxymethyl starch sodium combination.
Said medicine is the oral liquid of being processed by water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone, water and potassium sorbate combination.
In sum; The method for preparing of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone provided by the invention is before total flavones extracts; At first Radix Et Rhizoma Fagopyri Tatarici is steamed the rutin hydrolase that knocks out wherein, the water solublity total flavones main component rutin in the Radix Et Rhizoma Fagopyri Tatarici is kept effectively, again the Radix Et Rhizoma Fagopyri Tatarici behind the enzyme denaturing is carried out under specific process conditions that water is carried, alcohol extraction; Drying etc., thus make the water solublity extractive of general flavone; This method for preparing is simple, and extraction ratio is high, and prepared extractive of general flavone can fully water-solublely be utilized by human body, farthest brings into play its effect.In addition; Water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone provided by the invention can be used as raw material; Add acceptable accessories or auxiliary element again and process medicaments such as tablet, capsule, soft capsule, oral liquid, drop pill, spray, granule or injection, have huge medical value.
The specific embodiment
Do below in conjunction with the specific embodiment specific embodiments of the invention and to describe in detail:
Embodiment 1
Take by weighing the Radix Et Rhizoma Fagopyri Tatarici 20kg that area, the Liangshan Mountain, Sichuan produces, 100 ℃ of normal pressures steamed 120 minutes, took out, and added 6 times of water gagings and extracted 2 times at 70 ℃, and each 30 minutes, merge extractive liquid, filtered, and filtrating is concentrated into relative density under 50 ℃ be 1.02, makes concentrated solution A; Add volumetric concentration in the concentrated solution A and be that the ethanol volumetric concentration reaches 60% in 90% ethanol to the solution, left standstill 6 hours at 4 ℃ then, filter, make filtrating; With filtrate recycling ethanol, under 60 ℃, being concentrated into relative density then is 1.15, makes concentrated solution B; Concentrated solution B at 60 ℃ of drying under reduced pressure, is pulverized, make the 0.96kg buff powder, be water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone; The employing colorimetry detects, and the water solublity general flavone content reaches 39%; The employing HPLC detects, and rutin content reaches 21.2%.
With adding 6kg lactose and 2kg mannitol in the above-mentioned water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone that makes, mixing adopts oscillating granulator to granulate through 24 eye mesh screens; Granule is put into hot air drier, and to be dried to water content at 80 ℃ be 5%, takes out, and puts coldly, sieves out the instant Radix Et Rhizoma Fagopyri Tatarici tea that qualified granule packaging becomes the 2g/ bag.
Embodiment 2
Take by weighing the Radix Et Rhizoma Fagopyri Tatarici 30kg that area, the Liangshan Mountain, Sichuan produces, 120 ℃ of normal pressures steamed 85 minutes, took out, and added 10 times of water gagings and extracted 3 times at 90 ℃, and each 75 minutes, merge extractive liquid, filtered, and filtrating is concentrated into relative density under 75 ℃ be 1.10, makes concentrated solution A; Add volumetric concentration in the concentrated solution A and be that the ethanol volumetric concentration reaches 70% in 95% ethanol to the solution, left standstill 24 hours at 10 ℃ then, filter, make filtrating; With filtrate recycling ethanol, under 75 ℃, being concentrated into relative density then is 1.23, makes concentrated solution B; Concentrated solution B at 80 ℃ of drying under reduced pressure, is pulverized, make the 1.39kg buff powder, be water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone; The employing colorimetry detects, and the water solublity general flavone content reaches 30%; The employing HPLC detects, and rutin content reaches 21.8%.
With adding 1.65kg starch, 0.1kg magnesium stearate, 0.15kg carboxymethyl starch sodium in the above-mentioned water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone that makes; Mixing; Granulate; Drying is pressed into 10000 tablets of extractive of general flavone tablets, and this tablet has hypoglycemic, microcirculation improvement, anti-bacteria and anti-virus, antioxidation, effect such as anticancer.
Embodiment 3
Take by weighing the Radix Et Rhizoma Fagopyri Tatarici 50kg that area, the Liangshan Mountain, Sichuan produces, 150 ℃ of normal pressures steamed 5 minutes, took out, and added 15 times of water gagings and extracted 4 times at 100 ℃, and each 120 minutes, merge extractive liquid, filtered, and filtrating is concentrated into relative density under 100 ℃ be 1.15, makes concentrated solution A; Add volumetric concentration in the concentrated solution A and be that the ethanol volumetric concentration reaches 90% in 98% ethanol to the solution, left standstill 48 hours at 20 ℃ then, filter, make filtrating; With filtrate recycling ethanol, under 90 ℃, being concentrated into relative density then is 1.30, makes concentrated solution B; Concentrated solution B at 90 ℃ of drying under reduced pressure, is pulverized, make the 2.73kg buff powder, be water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone; The employing colorimetry detects, and general flavone content reaches 33%; The employing HPLC detects, and rutin content reaches 23.0%.
With adding pure water 50L in the above-mentioned water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone that makes extract is dissolved; Add adjuvant potassium sorbate 0.5kg again; Mixing; Filter, be distributed into 5000 bottles of extractive of general flavone oral liquids, this oral liquid has hypoglycemic, microcirculation improvement, anti-bacteria and anti-virus, antioxidation, effect such as anticancer.
Though describe in detail, be not to be qualification to this patent protection domain in conjunction with the specific embodiment specific embodiments of the invention.In claims institute restricted portion, various modifications that those skilled in the art can make without creative work or adjustment still receive the protection of this patent.
Claims (8)
1. the method for preparing of a water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone is characterized in that, may further comprise the steps: a, Radix Et Rhizoma Fagopyri Tatarici is steamed enzyme denaturing;
The water that adds 6～15 times of Radix Et Rhizoma Fagopyri Tatarici weight in b, the Radix Et Rhizoma Fagopyri Tatarici behind enzyme denaturing extracts 2～4 times at 70～100 ℃, and each extraction time is 30～120 minutes; Merge extractive liquid; Filter, filtrating is concentrated into relative density under 50～100 ℃ be 1.02～1.15, makes concentrated solution A;
C, to add volumetric concentration in the concentrated solution A be that the ethanol volumetric concentration reaches 60～90% in 90～98% ethanol to the solution, left standstill 6～48 hours at 0～20 ℃ then, filters, and makes filtrating;
D, with the filtrate recycling ethanol that step c makes, under 60～90 ℃, being concentrated into relative density then is 1.15～1.30, makes concentrated solution B; Concentrated solution B at 60～90 ℃ of drying under reduced pressure, is pulverized, make water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone.
2. the method for preparing of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone according to claim 1 is characterized in that: in the steps A, the condition that steams enzyme denaturing is to steam 5～120 minutes down at 100～150 ℃, and the enzyme that is gone out is a rutin hydrolase.
3. the water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone that makes of each said method of claim 1-2.
4. the application of the described water solublity Radix Et Rhizoma Fagopyri Tatarici of claim 3 extractive of general flavone in medication preparation.
5. the application of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone according to claim 4 in medication preparation is characterized in that: the dosage form of said medicine can be tablet, capsule, soft capsule, oral liquid, drop pill, spray, granule or injection.
6. the application of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone according to claim 4 in medication preparation is characterized in that: said medicine is the granule of being processed by water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone, lactose and mannitol combination.
7. the application of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone according to claim 4 in medication preparation is characterized in that: said medicine is the tablet of being processed by water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone, starch, magnesium stearate and carboxymethyl starch sodium combination.
8. the application of water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone according to claim 4 in medication preparation is characterized in that: said medicine is the oral liquid of being processed by water solublity Radix Et Rhizoma Fagopyri Tatarici extractive of general flavone, water and potassium sorbate combination.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104126788A (en) * | 2013-04-30 | 2014-11-05 | 四川好医生攀西药业有限责任公司 | Health-caring food capable of improving hyperglycemia and hyperlipidemia and preparation method thereof |
| CN104126786A (en) * | 2013-04-30 | 2014-11-05 | 四川好医生攀西药业有限责任公司 | Health-caring product for improving hyperglycemia and hyperlipidemia and preparation method thereof |
| CN105795480A (en) * | 2016-04-08 | 2016-07-27 | 吉林鑫水科技开发有限公司 | Extraction and analysis method and application of flavone in buckwheat |
| CN106138240A (en) * | 2016-08-01 | 2016-11-23 | 四川农业大学 | A kind of extracting method of buckwheat total flavone |
| CN106309629A (en) * | 2016-08-24 | 2017-01-11 | 宁波枫叶杰科生物技术有限公司 | Herbal essence extract and and preparing method thereof |
| CN110558560A (en) * | 2019-07-25 | 2019-12-13 | 西乡县巴山荞园茶业有限公司 | Method for recycling bitter buckwheat soaking water and continuously recovering flavone |
| CN112293742A (en) * | 2020-11-02 | 2021-02-02 | 哈工大机器人南昌智能制造研究院 | Blood fat reducing tablet containing tartary buckwheat flavone and preparation method thereof |
| CN114129621A (en) * | 2021-11-11 | 2022-03-04 | 泸州品创科技有限公司 | Application of tartary buckwheat flavone in preparation of antibacterial or gastritis preventing and treating medicine or health-care product |
| CN114259047A (en) * | 2021-12-13 | 2022-04-01 | 山西农业大学山西功能食品研究院 | Tartary buckwheat polyphenol with dual activities of resisting oxidation and inhibiting cancer as well as preparation method and application thereof |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU904709A1 (en) * | 1979-04-10 | 1982-02-15 | Первый Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им. И.М.Сеченова | Rutin production method |
| KR20020015805A (en) * | 2000-08-23 | 2002-03-02 | 한수길 | Extracting process of highly purified natural rutin from buckwheat |
| CN1385428A (en) * | 2001-05-15 | 2002-12-18 | 四川创星苦荞开发有限责任公司 | Process for extracting tartary buckwheat biological flavone |
| CN1927857A (en) * | 2006-09-25 | 2007-03-14 | 奈曼旗国有资产发展投资经营公司 | Extraction and purification process of buckwheat sprout total flavone |
| CN101066299A (en) * | 2007-06-13 | 2007-11-07 | 薛九荣 | Extracting process and product of tartary buckwheat extract with rich tartary buckwheat flavone |
| CN102224865A (en) * | 2011-04-24 | 2011-10-26 | 甘肃长征药业科技有限公司 | Completely water-soluble bitter buckwheat tea and preparation technology thereof |
| CN102429062A (en) * | 2011-11-23 | 2012-05-02 | 耿福能 | Preparation method for highly nutritional pill-shaped bitter buckwheat tea |
-
2012
- 2012-05-05 CN CN2012101364379A patent/CN102641343A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SU904709A1 (en) * | 1979-04-10 | 1982-02-15 | Первый Московский Ордена Ленина И Ордена Трудового Красного Знамени Медицинский Институт Им. И.М.Сеченова | Rutin production method |
| KR20020015805A (en) * | 2000-08-23 | 2002-03-02 | 한수길 | Extracting process of highly purified natural rutin from buckwheat |
| CN1385428A (en) * | 2001-05-15 | 2002-12-18 | 四川创星苦荞开发有限责任公司 | Process for extracting tartary buckwheat biological flavone |
| CN1927857A (en) * | 2006-09-25 | 2007-03-14 | 奈曼旗国有资产发展投资经营公司 | Extraction and purification process of buckwheat sprout total flavone |
| CN101066299A (en) * | 2007-06-13 | 2007-11-07 | 薛九荣 | Extracting process and product of tartary buckwheat extract with rich tartary buckwheat flavone |
| CN102224865A (en) * | 2011-04-24 | 2011-10-26 | 甘肃长征药业科技有限公司 | Completely water-soluble bitter buckwheat tea and preparation technology thereof |
| CN102429062A (en) * | 2011-11-23 | 2012-05-02 | 耿福能 | Preparation method for highly nutritional pill-shaped bitter buckwheat tea |
Non-Patent Citations (1)
| Title |
|---|
| 周瑞雪，等: "苦荞黄酮类化合物的提取工艺", 《中药材》 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104126788A (en) * | 2013-04-30 | 2014-11-05 | 四川好医生攀西药业有限责任公司 | Health-caring food capable of improving hyperglycemia and hyperlipidemia and preparation method thereof |
| CN104126786A (en) * | 2013-04-30 | 2014-11-05 | 四川好医生攀西药业有限责任公司 | Health-caring product for improving hyperglycemia and hyperlipidemia and preparation method thereof |
| CN104126786B (en) * | 2013-04-30 | 2016-08-10 | 四川好医生攀西药业有限责任公司 | A kind of health product improving high glucose and high fat and preparation method thereof |
| CN105795480A (en) * | 2016-04-08 | 2016-07-27 | 吉林鑫水科技开发有限公司 | Extraction and analysis method and application of flavone in buckwheat |
| CN106138240A (en) * | 2016-08-01 | 2016-11-23 | 四川农业大学 | A kind of extracting method of buckwheat total flavone |
| CN106309629A (en) * | 2016-08-24 | 2017-01-11 | 宁波枫叶杰科生物技术有限公司 | Herbal essence extract and and preparing method thereof |
| CN110558560A (en) * | 2019-07-25 | 2019-12-13 | 西乡县巴山荞园茶业有限公司 | Method for recycling bitter buckwheat soaking water and continuously recovering flavone |
| CN112293742A (en) * | 2020-11-02 | 2021-02-02 | 哈工大机器人南昌智能制造研究院 | Blood fat reducing tablet containing tartary buckwheat flavone and preparation method thereof |
| CN114129621A (en) * | 2021-11-11 | 2022-03-04 | 泸州品创科技有限公司 | Application of tartary buckwheat flavone in preparation of antibacterial or gastritis preventing and treating medicine or health-care product |
| CN114259047A (en) * | 2021-12-13 | 2022-04-01 | 山西农业大学山西功能食品研究院 | Tartary buckwheat polyphenol with dual activities of resisting oxidation and inhibiting cancer as well as preparation method and application thereof |
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Application publication date: 20120822 |