CN104666643A - Compound plains coreopsis product, as well as preparation method and application thereof - Google Patents
Compound plains coreopsis product, as well as preparation method and application thereof Download PDFInfo
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Abstract
The invention relates to a compound plains coreopsis product, as well as a preparation method and application thereof. The compound plains coreopsis product is prepared into a medicament, a health product or food from raw materials such as 0.8 to 6 parts by weight of plains coreopsis, 0.8 to 6 parts by weight of ilex latifolia thumb, 0.5 to 4 parts by weight of ampelopsis grossedentata and 0.2 to 2 parts by weight of stevia rebaudiana, as well as other edible or medicinal auxiliaries, according to the method. The compound plains coreopsis product is applied to the symptoms of hypertension, hyperlipidemia, hyperglycemia and the like, and has the advantages of high stability, efficiency and safety and the like, good curative effects are achieved, and a preparation process is simple and suitable for industrial production.
Description
Technical field
The invention belongs to Chinese medicine, health product technology field, relate in particular to compound recipe snow chrysanthemum product and its preparation method and application.
Background technology
" three-hypers disease " refers to hypertension, hyperglycemia (diabetes) and hyperlipemia.They be modern society derive from " affluenza ", possible individualism, also may be interrelated.As: diabetes patient is easy to suffer from hypertension or hyperlipidemia simultaneously, and hyperlipidemia is the principal element of arteriosclerosis formation and development, and arteriosclerotic's blood vessel elasticity difference aggravation blood pressure raises.So occur any one in these three kinds of illness, the later stage all easily defines " three-hypers disease ".Along with the change of growth in the living standard and rhythm of life, be called as " three-hypers disease " (i.e. hypertension, hyperglycemia and the hyperlipidemia) of " affluenza ", become the commonly encountered diseases of more than 50 years old middle-aged and elderly people health, the number of cardiovascular and cerebrovascular disease is died from every year up to 1,500 ten thousand people in the whole world, occupies the various cause of the death the first.In the Chinese ten large causes of death, the mortality rate relevant to metabolic disease is just up to 35.7%, and the death toll relevant to " three-hypers " also accounts for 27% of total death toll.World Health Organization (WHO) once clearly proposed, and prevented the first line of defence of cardiovascular diseases from reducing " three-hypers " exactly and controlling " three-hypers ".
Flos Chrysanthemi is the dry capitulum of feverfew chrysanthemum Chrysanthemum morifolium Ramat., sweet, bitter, is slightly cold, has effect of loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.The kind of Flos Chrysanthemi is a lot, and different chrysanthemums has certain difference in medicinal efficacy, such as Flos Chrysanthemi heat-clearing and toxic substances removing, relaxing muscles and tendons to promote blood circulation, hepatoprotective improving eyesight, Flos Chrysanthemi liver heat removing and eyesight improving, Herba Tagetis Patulae wind-dispelling heat-dissipating, Herba Dendranthematis indici heat-clearing and toxic substances removing, Folium Stevlae Rebaudianae adjust blood pressure, blood fat reducing, blood sugar lowering, snow chrysanthemum removing toxic substances removing dampness etc.Therefore, select suitable Flos Chrysanthemi type, rational medical material of arranging in pairs or groups, for specific health purpose, just can reach the effect of getting twice the result with half the effort.
In prior art, Flos Chrysanthemi is utilized to have a lot as the report of health promoting product, wherein the pertinent literature of prevention and therapy hypertension, hyperlipidemia or hyperglycemia is quite a few, as patent CN201110451691.3 discloses a kind of compound health-care tea containing Ampelopsis grossedentata and preparation method thereof, be the leaf with Ampelopsis grossedentata, stem branch and Flos Chrysanthemi, Folium Mori, Folium Nelumbinis be prepared from jointly, but this invention mainly highlights the effect of Ampelopsis grossedentata tender leaf and stem branch, the consumption of its ZHONGJUHUA is little, and not indicate which kind of Flos Chrysanthemi be best medicinal ingredient; Patent application CN201410628445.4 discloses a kind of Folium Ilicis wine and preparation method thereof, utilize effect of wine blood circulation promoting and blood stasis dispelling, the medical materials such as collocation Folium Ilicis, Gegen tablets, Fructus Crataegi, Folium Stevlae Rebaudianae powder, Medulla Junci, Fructus Mume, reach the blood stasis dispelling that heals, the object of blood pressure lowering of invigorating blood circulation, the health wine of this invention is the another selection that consumer provides alcohol product; Patent application CN201310658985.2 Chinese medicine composition disclosing blood pressure lowering and preparation method thereof, said composition is made up of 12 kinds of medical materials such as Fructus Arctii, Herba Apocyni veneti, snow chrysanthemum, Folium Ilicis, Stigma Maydis, Herba Taxillis, this invention crude drug composition is complicated, and fails to obtain ideal effect in blood fat reducing, blood sugar lowering.
Although at present all have a lot for the Chinese and western drugs of hypertension, hyperlipidemia and hyperglycemia and health promoting product, report for work less to " three-hypers " is all medicable, the product wherein only utilizing snow chrysanthemum and other Chinese crude drugs to make is less simultaneously.Research worker of the present invention is to avenge chrysanthemum for eliminating the basic raw material of three-hypers, eat with the Flos Chrysanthemi of other kinds, Folium Camelliae sinensis and part medicine the medical material shared and carried out conscientious careful screening study, in the hope of bring for extensive patients all have in blood pressure lowering, blood fat reducing and blood sugar lowering safe and efficient, and dosage form is various, can for the product of different crowd.Have no the compositions or compound preparation that adopt snow chrysanthemum, Ampelopsis grossedentata, Folium Ilicis and Folium Stevlae Rebaudianae to make and the relevant report simultaneously reducing " three-hypers " thereof at present.
Summary of the invention
The object of this invention is to provide and a kind ofly form simple, active component utilization rate is high, product type is various compound recipe snow chrysanthemum product and preparation method thereof, and in preparation, there is blood pressure lowering, blood fat reducing and blood sugar lowering three and fall application in the medicine of function, health product or food.
The present invention is achieved in that
A kind of compound recipe snow chrysanthemum product, it is characterized in that, described product is made up of the raw material of following weight portion: snow chrysanthemum 0.8-6 part, Folium Ilicis 0.8-6 part, Ampelopsis grossedentata 0.5-4 part, Folium Stevlae Rebaudianae 0.2-2 part.
Further, the parts by weight of raw materials of described product is: snow chrysanthemum 1.5-3 part, Folium Ilicis 1.5-3 part, Ampelopsis grossedentata 1-2 part, Folium Stevlae Rebaudianae 0.5-1 part.
Aforesaid compound recipe snow chrysanthemum product can be medicine, health product or food.
Further, the dosage form of described medicine or health product is tablet, capsule, granule or oral liquid; The kind of described food is tea beverage, teabag.
The invention also discloses the preparation method of compound recipe snow chrysanthemum product.
Wherein, the preparation method of medicine or health product comprises the following steps:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 65%-100%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, spraying dry or directly add the snow chrysanthemum volatile oil extracted, adds pharmaceutic adjuvant, makes required tablet, capsule, granule, oral liquid.
Particularly, tablet is preparation like this:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of tablet total amount 15-20% in medicated powder after the drying, all the other are supplemented to full dose with pregelatinized Starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate with 8% starch slurry, dry, add the magnesium stearate of tablet total amount 0.5-1%, tabletting, to obtain final product.
Capsule is preparation like this:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of capsule total amount 12-15% in medicated powder after the drying, all the other are supplemented to full dose with corn starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate, dry, add the magnesium stearate of total amount 0.5-1%, encapsulated after mixing, to obtain final product.
Granule is preparation like this:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add snow chrysanthemum volatile oil, the dextrin collected in medicated powder after the drying, mixing, granulate, dry, granulate, packaging, obtains granule.
Oral liquid is preparation like this:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, add water to 50% of total amount, add the snow chrysanthemum volatile oil of collection, mixing, simple syrup adds to sugar content 15-20%, add 0.1% sodium benzoate, adding distil water is to full dose, and mixing, filters, embedding, obtains oral liquid.
Wherein, the preparation method of compound recipe snow chrysanthemum tea beverage comprises following steps:
1) will avenge chrysanthemum, leaf of Folium Stevlae Rebaudianae is pulverized, be alcohol reflux 1-3 time of 20%-50% by the concentration of 6-10 times amount, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merging is for subsequent use;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, for subsequent use;
3) by step 1 and 2 obtained extract solutions, add the chitosan of crude drug amount 1%, leave standstill 24 hours, filter, filtrate adds water, and stirs evenly, and adjust ph, to 4-5, adds the crystal sugar of beverage total amount 6-9%, the citric acid of 0.05-0.12%, aseptic filtration, filtrate subpackage, rolls lid, makes beverage.
Wherein the preparation method of compound recipe snow chrysanthemum bagged tea comprises following steps:
1) get the snow chrysanthemum of formula ratio, Folium Stevlae Rebaudianae, at 0-6 DEG C, vacuum drying is less than 5% to water content, is ground into fine powder, crosses 60 mesh sieves for subsequent use;
2) lectuce tea powder getting formula ratio 50%-70% is broken into the coarse powder that granularity is 0.2-0.3mm, the Ampelopsis grossedentata branch and leaf of all the other Folium Ilicis and formula ratio, add 6-10 times amount, concentration is 55%-75% alcoholic solution reflux, extract, 1-2 time, each 1-2 hour, merge extractive liquid, filter, concentrating and being formed in relative density at 55-60 DEG C is the extractum of 1.20-1.30;
3) open parch pot, adjustment temperature is 75-85 DEG C, and stirring rod speed is 80-120 rev/min, put into after Folium Ilicis coarse powder stir-fries 10-20 minute, add step 1) snow inulin and Folium Stevlae Rebaudianae powder, and step 2) obtained extract extractum, after abundant mixing, mixture is put into sterilizing, drying equipment, first high temperature sterilize, be then cooled to rapidly less than 80 DEG C, cold drying, cross 80 mesh sieve granulate, subpackage, to obtain final product.
Another object of the present invention is to provide aforesaid compound recipe snow chrysanthemum product to be had blood pressure lowering, blood sugar lowering and blood fat reducing three in preparation and falls application in functional product.
Compared with prior art, the present invention adopt raw material, effect and mechanism as follows:
Snow chrysanthemum: have another name called double-colored Coreopsis basalis, the Kunlun snow chrysanthemum, property is put down, sweet in the mouth.There is the function of heat-clearing and toxic substances removing, removing dampness.Originate in area, Middle West, western part of China is cultivated, due to growing environment pollute less, height above sea level, contain the mineral element to useful 18 seed amino acids, more than 30 kind of Flavonoid substances and the needed by human of human body, also have abundant organic acid, terpenes, vitamin, enzyme and polysaccharide, to hypertension, hyperlipidemia, hyperglycemia, coronary heart disease etc., there is special efficacy, obviously can reduce triglyceride and the cholesterol of serum, and have effect of sterilization, antiinflammatory, fat-reducing, preventing cold and chronic enteritis, also there is goodish opsonic action for insomnia.Wherein, general flavone content reaches 12%, considerably beyond other various chrysanthemum classes.
Folium Stevlae Rebaudianae: be a kind of perennial catananche, containing inulin glycosides in blade, its sugariness is 150 ~ 300 times of sucrose, is a kind of fabulous natural sweetener.And some disease can be treated, and as controlled diabetes, blood pressure lowering, also effective in cure to obesity, heart disease, children's worm tooth etc., and enhance metabolism, the effect of strong health.Leaf is containing stevioside (Stevioside), steviolbioside (Steviolbioside), stevioside A, B (rebaudisides A, B) isoreactivity composition and sweet ingredient.Pharmacological testing shows, its effective ingredient Stevia rebaudiana acid suppresses the synthesis of sugar and oxygen to absorb, and blood sugar level obviously declines; In addition also there is obvious vasodilative effect, therefore significant curative effect is had to adjustment blood pressure, vessel softening, reduction blood fat, blood sugar lowering, glucose in urine etc., and also there is antibacterial hemostasis, analgesia, fat-reducing and beauty, YIN nourishing and the production of body fluid promoting, help digest, promote effect of pancreas, spleen and stomach function and heat-clearing and toxic substances removing.
Ampelopsis grossedentata: have another name called Maoyanmei tea, Long Xucha, Ampelopsis grossedentata etc., formal name used at school Ampelopsis grossedentata.Be rich in 14 kinds of trace element such as 17 seed amino acids and potassium, calcium, ferrum, wherein effective ingredient dihydromyricetin, anthocyanidin, flavones content are very high, have sterilization antiinflammatory, heat-clearing and toxic substances removing, analgesia detumescence, lipid-lowering pressure-reducing hypoglycemic, the cough-relieving that wets one's whistle, improve the functions such as body immunity.The health-care effect aspect of Ampelopsis grossedentata, it three falls (fall blood is sticky, blood pressure lowering, blood sugar lowering), three anti-(antithrombotic, defying age, antitumor), three regulate the effect of (adjusting blood lipid, immunity moderation, adjustment the intestines and stomach) remarkable.
Folium Ilicis: Aquifoliaceae Ilex latifolia Thunb kind aiphyllium, is commonly called as tea fourth, Fu Dingcha, highland Lu's tea, is mainly distributed in southwest, sweet in the mouth, hardship, cold in nature, is a kind of traditional pure natural health-care beverage good merchantable brand of China.Containing 200 Multiple components such as Herba Lactucae formosanae Saponin, aminoacid, vitamin C, Polyphenols, flavonoid, caffeine, protein in Folium Ilicis, there is blood fat reducing, increase coronary artery blood flow, increase the effect such as blood supply of cardiac muscle, atherosclerosis, all have good preventive and therapeutic effect to symptoms such as the dizziness of Patients with Cardiovascular/Cerebrovascular Diseases, headache, uncomfortable in chest, weak, insomnias.Its delicate fragrance that becomes to sample tea has bitterness, then sweet cool, has clearing away heat and removing summer, eyesight-improving intelligence-developing, promoting the production of body fluid to quench thirst, diuresis heart tonifying, the cough-relieving that wets one's whistle, blood pressure lowering fat-reducing, presses down cancer anti-cancer, defying age, the multiple efficacies such as arteries and veins of invigorating blood circulation.
To sum up, the present invention utilizes the removing toxic substances of snow chrysanthemum, removing dampness, the obvious triglyceride of reduction serum and the effect of cholesterol, collocation Folium Stevlae Rebaudianae vessel softening, blood lipid-reducing blood sugar-decreasing, Ampelopsis grossedentata three falls, the health-care effect of three anti-, three conditions, and Folium Ilicis blood pressure lowering heart tonifying, anti-ageingly to invigorate blood circulation, each active component is collaborative, common potentiation mutually, can prevention and therapy hypertension, hyperlipidemia and hyperglycemia and related metabolic diseases thereof effectively.
The present invention will be described below to adopt test to come further:
Experiment 1, product of the present invention " three fall " effect test-recipe determination
1, test specimen
Test specimen: inventive samples: select tablet, capsule and granule that embodiment 1,3,4,10,11 is made, numbered samples 1-5;
Control sample 1: according to the extracting solution of patent application CN201310658985.2 embodiment 1 preparation, concentrating and being formed in relative density at 60 DEG C is the extractum of 1.20;
Control sample 2: the tablet prepared according to embodiment 1 formula and method for making, wherein not containing Folium Stevlae Rebaudianae;
Control sample 3: the tablet prepared according to embodiment 1 formula and method for making, is wherein replaced by Radix Puerariae by Ampelopsis grossedentata;
Control sample 4: the tablet prepared according to embodiment 1 formula and method for making, is wherein replaced by keemun black tea by Folium Ilicis.
2, test method
2.1 hypolipidemic pharmacological research
2.1.1 experimental animal
SD rat, body weight 180-220g, male and female half and half, cleaning grade standard, is divided into 12 groups at random: blank group, model group, DIAOXINXUE KANG group, sample 1-5 group, control sample 1-4 group, often organizes 10, sub-cage rearing.Except blank group, all the other are respectively organized rat and give high lipid food diet continuously after 14 days, and after randomly drawing the animal eyeball often organizing 30%, vascular plexus gets blood, detects the blood lipid levels such as T-CHOL (TC), triglyceride (TG).As a result, compare with blank group, high blood lipid model success rate reaches 99%, proves that modeling type is successful, after rejecting indivedual blood lipid level animal on the low side, carries out fat-reducing medicament experiment.
2.1.3 test method
After modeling, model group and blank group are normally fed, every day gavage normal saline 1ml, experimental group dosage is: DIAOXINXUE KANG group 30mgkg
-1; 1,4,5 groups, sample and comparative sample 2-4 group are all tablet, administration 0.15gkg
-1; 2 groups, sample is capsule, administration 0.1gkg
-1; 3 groups, sample is granule, administration 0.8gkg
-1; Comparative sample 1 group is extractum, and administration is equivalent to 7g crude drug kg
-1; Be equivalent to quantity 10 times.Porphyrize, mixing before above sample administration, dissolve with distilled water and make every 1ml containing above-mentioned dosage part.
Fed with high starts administration on the about the 15th day, tests each animal groups respectively through gavage oral administration, once a day 1ml, and successive administration is surrounding 28 days (after last administration, fasting be can't help drinking 8h) altogether.All animals is taken a blood sample through eye socket, gets serum, blood lipid level after detection administration.
2.2 blood sugar lowering pharmacological research
2.2.1 experimental animal: NIH mice, male, body weight 18.0-23.1g, cleaning grade standard.Get normal mouse tail vein injection alloxan (72mgkg
-1), predict serum level of glucose after 72h, select blood glucose value at 16mmolL
-1above person studies.Be divided into 12 groups at random: blank group, model group, sample 1-5 group, control sample 1-4 group, metformin hydrochloride (150mgkg
-1) group, often organize 10, sub-cage rearing.
2.2.2 test method
After modeling, model group and blank group are normally fed, every day gavage normal saline 1ml, experimental group dosage is: 1,4,5 groups, sample and comparative sample 2-4 group are all tablet, administration 0.15gkg
-1; 2 groups, sample is capsule, administration 0.1gkg
-1; 3 groups, sample is granule, administration 0.8gkg
-1; Comparative sample 1 group is extractum, is equivalent to 7g crude drug kg
-1; Be equivalent to quantity 10 times.Porphyrize, mixing before above sample administration, dissolve with distilled water and make every 1ml containing above-mentioned dosage part, 1ml once a day, continuous gastric infusion 7 days.1h after last administration, mouse orbit venous plexus measuring blood sugar of blood extracting level.
2.3 hypotensor pharmacological research
2.3.1 experimental animal: Wistar rat, male, body weight 250 ± 26.3g, is divided into 12 groups at random: matched group (potassium chloride), sample 1-5 group, control sample 1-4 group, Propranolol group, often organizes 10, sub-cage rearing.
2.3.2 test method: thorax artery myocardium vessel tension force organon
2.3.2.1 the preparation of thoracic aorta vascular ring is with stable:
Rat sacrificed by decapitation, opens breast and takes out thoracic aorta rapidly, is placed in and uses mist (95%O in advance
2and 5%CO
2) in the saturated K-H liquid of 4 DEG C, rinse to without bloodstain, remove fatty tissue and the connective tissue of periphery carefully, and be cut into the vascular ring that 2-3mm grows, vascular ring be placed in K-H liquid (the 37 DEG C of constant temperature, and continue to pass into 95%O filling 10ml
2and 5%CO
2mixed gas, pH=7.4) constant temperature sleeve bottle in, each root vascular ring two triangular forms hook runs through vascular ring tube chamber, and one end is fixed, and the other end is connected to tension pick-up, and tension variation is gathered and record by BL-420E biological functional system.Vascular ring adds rest tension about 2g, stablizes 90min, period every 15min K-H fluid exchange liquid of pre-temperature to 37 DEG C.After vascular ring complete stability, can formally test.
2.3.2.2 on the impact of the pre-shrunk vascular ring tension force of potassium chloride
After vascular ring is stable, with the KCl repetitive stimulation 3 times of 60mmol/L, bring out the maximum shrinkage amplitude of blood vessel, during continuous 3 same shrinkage amplitude difference <10% caused by stimulation, with this as 100% shrink tension.Trial drug is added respectively by table 3 dosage.
3, result
3.1 blood fat reducing result of the tests
Through statistics, lipid-lowering effect sees the following form 1.
Table 1 compound recipe snow chrysanthemum product lipid-lowering effect
* P<0.05 is compared with comparative sample group,
p<0.05 is compared with modeling group.
After the treatment of a course for the treatment of, sample sets and control sample group all reduce T-CHOL (TC), triglyceride (TG) level at varying level.But obviously can find out, inventive samples 1-3 and tablet, capsule and granule best results, apparently higher than DIAOXINXUE KANG group therapeutic effect, compound recipe of the present invention snow chrysanthemum product curative effect is described certainly; Compare with comparative sample 1-4 (namely lack medical material simply, or change medical material collocation), show to adopt prescription medical material of the present invention to combine, formula is reasonable; Sample 4 groups of therapeutic effect that low formula ratio is made are undesirable, sample 5 groups of curative effects zero difference compared with sample 1-3 group of high formula ratio, and the consumption of comprehensive medical material, safety and economy etc., therefore select formula amount ranges of the present invention.
3.2 blood sugar lowering result of the tests
Through statistics, effect sees the following form.
Table 2 compound recipe snow chrysanthemum product blood sugar decreasing effect
* P<0.05 is compared with comparative sample group,
p<0.05 is compared with modeling group.
After the treatment of 7d, sample sets and control sample group reduce the blood sugar level of model mice all in various degree, but can obviously find out, inventive samples 1-3 and tablet, capsule and granule best results, apparently higher than metformin hydrochloride group therapeutic effect, compound recipe of the present invention snow chrysanthemum product curative effect is described certainly; Compare with comparative sample 1-4 (namely lack medical material simply, or change medical material collocation), show to adopt prescription medical material of the present invention to combine, formula is reasonable; Sample 4 groups of therapeutic effect that low formula ratio is made are undesirable, sample 5 groups of curative effects zero difference compared with sample 1-3 group of high formula ratio, and the consumption of comprehensive medical material, safety and economy etc., therefore select formula amount ranges of the present invention.
3.3 blood pressure lowering result of the tests
Through statistics, the effect of blood pressure lowering sees the following form 3.
Table 3 compound recipe snow chrysanthemum product blood pressure lowering effect
Above result shows, sample sets and control sample group reduce the blood pressure level of model mice all in various degree, but can obviously find out, inventive samples 1-3 and tablet, capsule and granule best results, higher than Propranolol group therapeutic effect, compound recipe of the present invention snow chrysanthemum product curative effect is described certainly; Compare with comparative sample 1-4 (namely lack medical material simply, or change medical material collocation), show to adopt prescription medical material of the present invention to combine, formula is reasonable; Sample 4 groups of therapeutic effect that low formula ratio is made are undesirable, sample 5 groups of curative effects zero difference compared with sample 1-3 group of high formula ratio, and the consumption of comprehensive medical material, safety and economy etc., therefore select formula amount ranges of the present invention.
Experiment 2, Study on Preparation
1, the preparation of medicine or health product:
The volatile oil of snow chrysanthemum is first collected by the present invention, avoids the shortcoming that traditional method only utilizes the medicinal liquid after decoction; The method of low-concentration ethanol backflow is adopted to extract total flavones, the stevioside isoreactivity composition avenged in chrysanthemum and Folium Stevlae Rebaudianae, the method of soak by water extracts dihydromyricetin, total flavones, Total saponin and aminoacid etc. in Ampelopsis grossedentata, Folium Ilicis, active component is not only made to obtain sufficient extraction, and the method separately extracted can also reduce influencing each other between each composition, effective ingredient purity is improved, reduces introducing and the content of impurity; Adopt spray-dired method dry extract mastic, energy consumption is low, pollute little, moisture evaporation rapidly, drying time is short, economize the technique such as devaporation, pulverizing, and quality of item is good, stability is strong, dissolubility is high.
2, the preparation of teabag:
Snow chrysanthemum, Folium Stevlae Rebaudianae are first carried out vacuum drying by the present invention under cryogenic, effectively maintain effect of active constituents of medicine, and the former fragrance of Flos Chrysanthemi and mouthfeel; Part Folium Ilicis uses the former powder of parch, has both remained delicate fragrance and the glycol of tea, again due to by remainder and Ampelopsis grossedentata water extraction acquisition extract altogether, active component is fully used, also improves the stripping of teabag.The teabag obtained is made all to achieve extraordinary effect like this in color, effect etc.
The safety testing of experiment 3, product of the present invention
Get the sample A1-A9 that embodiment of the present invention 1-9 is obtained, according to people's consumption 10 times, the consumption of 20 times, 50 times, toxicological experiment research is carried out with mice, results of animal shows, people's consumption 10 times, 20 times time Mouse Weight without significant change, be a cup too low depressed, movable to reduce or other symptom occurs, and has slight lethargy phenomenon during people's consumption 50 times.Prove that product toxic and side effects of the present invention is little, be very beneficial for Clinical practice.
The stability test of experiment 4, product of the present invention
Get the sample A1-A9 that embodiment of the present invention 1-9 is obtained, temperature 40 DEG C ± 2 DEG C, under the condition of relative humidity 75% ± 5%, carry out accelerated stability test, once investigate in duration of test 1st month, 2 months, 3 months, 6 samplings at the end of month respectively; With character, moisture, effective active component content and health examination for index, check the stability of product.Result shows: product prepared by the present invention is stored under accelerated test condition, each investigation project is showed no exception, and moisture change controls within 5%, and active constituent content significant change does not occur yet, its health examination all meets expection regulation, shows that product quality of the present invention meets the requirements.
From above data, the product that the present invention utilizes the compositions such as snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata, Folium Ilicis to make, effectively can prevent " three-hypers " disease, through investigations such as curative effect, safety, product qualities, corresponding index reaches expection requirement all well, illustrate that recipe design of the present invention is reasonable, preparation method is simply controlled, has a good application prospect.
Detailed description of the invention
Explain the present invention further below in conjunction with embodiment and test example, but content of the present invention is not limited to the following stated.
Embodiment
Embodiment 1: tablet and preparation
Formula: snow chrysanthemum 2.5kg, Folium Ilicis 2.0kg, Ampelopsis grossedentata 1.5kg part, Folium Stevlae Rebaudianae 1kg
Method for making: 1) will inulin be avenged broken, for subsequent use with extraction by steam distillation volatile oil; Medicinal residues and leaf of Folium Stevlae Rebaudianae are the alcohol reflux 2 times of 30% by the concentration of 8 times amount, each 1 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.20;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 3 times of 8 times amount, each 2 hours, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.20;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of tablet total amount 15% in medicated powder after the drying, all the other are supplemented to full dose with pregelatinized Starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate with 8% starch slurry, dry, add the magnesium stearate of tablet total amount 1%, tabletting, obtains 1000, tablet.The heavy 0.5g of every sheet.
Usage and dosage: one time 2,2-3 time on the one.
Embodiment 2: tablet and preparation
Formula: snow chrysanthemum 2.0kg, Folium Ilicis 2.5kg, Ampelopsis grossedentata 0.5kg, Folium Stevlae Rebaudianae 0.5kg
Method for making: 1) will inulin be avenged broken, for subsequent use with extraction by steam distillation volatile oil; Medicinal residues and leaf of Folium Stevlae Rebaudianae are the alcohol reflux 2 times of 40% by the concentration of 8 times amount, each 1 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 60 DEG C be the extractum of 1.15;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 3 times of 8 times amount, each 2 hours, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 60 DEG C be the extractum of 1.10;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of tablet total amount 20% in medicated powder after the drying, all the other are supplemented to full dose with pregelatinized Starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate with 8% starch slurry, dry, add the magnesium stearate of tablet total amount 0.5%, tabletting, obtains 1000, tablet.
Embodiment 3: capsule and preparation
Formula: snow chrysanthemum 0.8kg, Folium Ilicis 0.8kg, Ampelopsis grossedentata 0.5kg, Folium Stevlae Rebaudianae 0.2kg
Method for making: 1) will inulin be avenged broken, for subsequent use with extraction by steam distillation volatile oil; Medicinal residues and leaf of Folium Stevlae Rebaudianae are the alcohol reflux 3 times of 20% by the concentration of 10 times amount, each 0.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55 DEG C be the extractum of 1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 2 times of 10 times amount, each 3 hours, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55 DEG C be the extractum of 1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of capsule total amount 12% in medicated powder after the drying, all the other are supplemented to full dose with corn starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate, dry, add the magnesium stearate of total amount 0.5-1%, encapsulated after mixing, obtain capsule 1000.Every dress 0.3g.
Usage and dosage: one time 2,2-3 time on the one.
Embodiment 4: granule and preparation
Formula: snow chrysanthemum 6kg, Folium Ilicis 6kg, Ampelopsis grossedentata 4kg, Folium Stevlae Rebaudianae 2kg
Method for making: 1) will inulin be avenged broken, for subsequent use with extraction by steam distillation volatile oil; Medicinal residues and leaf of Folium Stevlae Rebaudianae are the alcohol reflux 1.5 hours of 50% by the concentration of 6 times amount, extracting liquid filtering, and concentrated to be formed in relative density at 60 DEG C be the extractum of 1.25;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 4 times of 6 times amount, each 1 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 60 DEG C be the extractum of 1.20;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add snow chrysanthemum volatile oil, the dextrin collected in medicated powder after the drying and be supplemented to full dose, mixing, granulates, dry, granulate, packaging, obtains granule 1000 bags.Every packed 5g.
Usage and dosage: one time 1 bag, 2-3 time on the one.
Embodiment 5: oral liquid and preparation
Formula: snow chrysanthemum 1.5kg, Folium Ilicis 1.5kg, Ampelopsis grossedentata 1kg, Folium Stevlae Rebaudianae 0.5kg
Method for making: 1) will inulin be avenged broken, for subsequent use with extraction by steam distillation volatile oil; Medicinal residues and leaf of Folium Stevlae Rebaudianae are the alcohol reflux 2 times of 25% by the concentration of 9 times amount, each 1.5 hours, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 60 DEG C be the extractum of 1.15;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 4 times of 9 times amount, each 1 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 60 DEG C be the extractum of 1.25;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, add water to 50% of total amount, add the snow chrysanthemum volatile oil of collection, mixing, simple syrup adds to sugar content 15%, add 0.1% sodium benzoate, adding distil water is to full dose, and mixing, filters, embedding, obtains oral liquid 1000.Often prop up dress 10ml.
Usage and dosage a: 10ml, 2-3 time on the one.
Embodiment 6: tea beverage and preparation
Formula: snow chrysanthemum 4kg, Folium Ilicis 1.5kg, Ampelopsis grossedentata 1kg, Folium Stevlae Rebaudianae 0.5kg
Method for making: 1) will avenge chrysanthemum, leaf of Folium Stevlae Rebaudianae is pulverized is the alcohol reflux 3 times of 40% by the concentration of 6 times amount, each 0.5 hour, extracting liquid filtering, and filtrate merging is for subsequent use;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 2 times of 10 times amount, each 2 hours, extracting liquid filtering, filtrate merges, for subsequent use;
3) by step 1 and 2 obtained extract solutions, add the chitosan of crude drug amount 1%, leave standstill 24 hours, filter, filtrate adds water, and stirs evenly, and adjust ph, to 4-5, adds the crystal sugar of beverage total amount 6%, the citric acid of 0.05%, aseptic filtration, filtrate subpackage, rolls lid, makes beverage 1000 box.Every box-packed 150ml.
Usage and dosage: one time 1 bottle, 2-3 time on the one.
Embodiment 7: tea beverage and preparation
Formula: snow chrysanthemum 3kg, Folium Ilicis 3kg, Ampelopsis grossedentata 2kg, Folium Stevlae Rebaudianae 1kg
Method for making: 1) will avenge chrysanthemum, leaf of Folium Stevlae Rebaudianae is pulverized is the alcohol reflux 1.5 hours of 30% by the concentration of 10 times amount, and extracting liquid filtering is for subsequent use;
2) Ampelopsis grossedentata, Folium Ilicis is got, by the water boiling and extraction 4 times of 6 times amount, each 1 hour, extracting liquid filtering, filtrate merges, for subsequent use;
3) by step 1 and 2 obtained extract solutions, add the chitosan of crude drug amount 1%, leave standstill 24 hours, filter, filtrate adds water, and stirs evenly, and adjust ph, to 4-5, adds the crystal sugar of beverage total amount 9%, the citric acid of 0.12%, aseptic filtration, filtrate subpackage, rolls lid, makes beverage 1000 box.Every box-packed 150ml.
Embodiment 8: teabag and preparation
Formula: snow chrysanthemum 6kg, Folium Ilicis 3kg, Ampelopsis grossedentata 4kg, Folium Stevlae Rebaudianae 2kg
Method for making: 1) get the snow chrysanthemum of formula ratio, Folium Stevlae Rebaudianae, at 0 DEG C, vacuum drying is less than 5% to water content, is ground into fine powder, crosses 60 mesh sieves for subsequent use;
2) lectuce tea powder getting formula ratio 50% is broken into the coarse powder that granularity is 0.2-0.3mm, the Ampelopsis grossedentata branch and leaf of all the other Folium Ilicis and formula ratio, add 6 times amount, concentration is 85% alcoholic solution reflux, extract, 2 times, each 1 hour, merge extractive liquid, filter, concentrating and being formed in relative density at 55-60 DEG C is the extractum of 1.20-1.30;
3) open parch pot, regulate temperature to be 75 DEG C, stirring rod speed is 80 revs/min, put into after Folium Ilicis coarse powder stir-fries 10 minutes, add step 1) snow inulin and Folium Stevlae Rebaudianae powder, and step 2) obtained extract extractum, after abundant mixing, mixture is put into sterilizing, drying equipment, first high temperature sterilize, be then cooled to rapidly less than 80 DEG C, cold drying, cross 80 mesh sieve granulate, be distributed into 1000 bags, obtain final product.
Usage and dosage: each 1 bag, 2-3 time on the one.
Embodiment 9: teabag and preparation
Formula: snow chrysanthemum 3kg, Folium Ilicis 2kg, Ampelopsis grossedentata 0.5kg, Folium Stevlae Rebaudianae 0.5kg
Method for making: 1) get the snow chrysanthemum of formula ratio, Folium Stevlae Rebaudianae, at 6 DEG C, vacuum drying is less than 5% to water content, is ground into fine powder, crosses 60 mesh sieves for subsequent use;
2) lectuce tea powder getting formula ratio 70% is broken into the coarse powder that granularity is 0.2-0.3mm, the Ampelopsis grossedentata branch and leaf of all the other Folium Ilicis and formula ratio, add 10 times amount, concentration is 55% alcoholic solution reflux, extract, 2 hours, merge extractive liquid, filter, concentrating and being formed in relative density at 55-60 DEG C is the extractum of 1.20-1.30;
3) open parch pot, regulate temperature to be 85 DEG C, stirring rod speed is 120 revs/min, put into after Folium Ilicis coarse powder stir-fries 20 minutes, add step 1) snow inulin and Folium Stevlae Rebaudianae powder, and step 2) obtained extract extractum, after abundant mixing, mixture is put into sterilizing, drying equipment, first high temperature sterilize, be then cooled to rapidly less than 80 DEG C, cold drying, cross 80 mesh sieve granulate, be distributed into 1000 bags, obtain final product.
Embodiment 10: high formula ratio tablet
Formula: snow chrysanthemum 7kg, Folium Ilicis 7kg, Ampelopsis grossedentata 5kg, Folium Stevlae Rebaudianae 3kg
Method for making: with embodiment 1.
Embodiment 11: low formula ratio tablet
Formula: snow chrysanthemum 0.5kg, Folium Ilicis 0.5kg, Ampelopsis grossedentata 0.3kg, Folium Stevlae Rebaudianae 0.1kg
Method for making: with embodiment 1.
Claims (13)
1. a compound recipe snow chrysanthemum product, it is characterized in that, described product is made up of the raw material of following weight portion: snow chrysanthemum 0.8-6 part, Folium Ilicis 0.8-6 part, Ampelopsis grossedentata 0.5-4 part, Folium Stevlae Rebaudianae 0.2-2 part.
2. compound recipe snow chrysanthemum product as claimed in claim 1, it is characterized in that, the parts by weight of raw materials of described product is: snow chrysanthemum 1.5-3 part, Folium Ilicis 1.5-3 part, Ampelopsis grossedentata 1-2 part, Folium Stevlae Rebaudianae 0.5-1 part.
3. compound recipe snow chrysanthemum product as claimed in claim 1 or 2, it is characterized in that, described product is medicine, health product or food.
4. compound recipe snow chrysanthemum product as claimed in claim 3, it is characterized in that, the dosage form of described medicine or health product is tablet, capsule, granule or oral liquid.
5. compound recipe snow chrysanthemum product as claimed in claim 3, it is characterized in that, the kind of described food is tea beverage, teabag.
6. compound recipe snow chrysanthemum product as claimed in claim 4, it is characterized in that, the preparation method of described compound recipe snow chrysanthemum medicine or health product comprises the following steps:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 65%-100%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, spraying dry or directly add the snow chrysanthemum volatile oil extracted, adds pharmaceutic adjuvant, makes required tablet, capsule, granule, oral liquid.
7. compound recipe snow chrysanthemum product as claimed in claim 6, is characterized in that, the preparation method of described compound recipe snow chrysanthemum tablet is:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of tablet total amount 15-20% in medicated powder after the drying, all the other are supplemented to full dose with pregelatinized Starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate with 8% starch slurry, dry, add the magnesium stearate of tablet total amount 0.5-1%, tabletting, to obtain final product.
8. compound recipe snow chrysanthemum product as claimed in claim 6, is characterized in that, the preparation method of described compound recipe snow chrysanthemum capsule agent is:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add the microcrystalline Cellulose of capsule total amount 12-15% in medicated powder after the drying, all the other are supplemented to full dose with corn starch, add the snow chrysanthemum volatile oil collected, be mixed evenly, granulate, dry, add the magnesium stearate of total amount 0.5-1%, encapsulated after mixing, to obtain final product.
9. compound recipe snow chrysanthemum product as claimed in claim 6, is characterized in that, the preparation method of described compound recipe snow chrysanthemum granules agent is:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, carry out spraying dry, add snow chrysanthemum volatile oil, the dextrin collected in medicated powder after the drying, mixing, granulate, dry, granulate, packaging, obtains granule.
10. compound recipe snow chrysanthemum product as claimed in claim 6, is characterized in that, the preparation method of described compound recipe snow chrysanthemum oral liquid is:
1) inulin will be avenged broken, for subsequent use with extraction by steam distillation volatile oil; The concentration of medicinal residues and leaf of Folium Stevlae Rebaudianae 6-10 times amount is alcohol reflux 1-3 time of 20%-50%, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.15-1.30;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, and concentrated to be formed in relative density at 55-60 DEG C be the extractum of 1.10-1.30;
3) by the extract extractum of aforementioned obtained snow chrysanthemum, Folium Stevlae Rebaudianae, Ampelopsis grossedentata and Folium Ilicis, add water to 50% of total amount, add the snow chrysanthemum volatile oil of collection, mixing, simple syrup adds to sugar content 15-20%, add 0.1% sodium benzoate, adding distil water is to full dose, and mixing, filters, embedding, obtains oral liquid.
11. compound recipe snow chrysanthemum products as claimed in claim 5, is characterized in that, the preparation method of described compound recipe snow chrysanthemum tea beverage comprises following steps:
1) will avenge chrysanthemum, leaf of Folium Stevlae Rebaudianae is pulverized, be alcohol reflux 1-3 time of 20%-50% by the concentration of 6-10 times amount, each 0.5-1.5 hour, extracting liquid filtering, and filtrate merging is for subsequent use;
2) Ampelopsis grossedentata, Folium Ilicis is got, by water boiling and extraction 2-4 time of 6-10 times amount, each 1-3 hour, extracting liquid filtering, filtrate merges, for subsequent use;
3) by step 1 and 2 obtained extract solutions, add the chitosan of crude drug amount 1%, leave standstill 24 hours, filter, filtrate adds water, and stirs evenly, and adjust ph, to 4-5, adds the crystal sugar of beverage total amount 6-9%, the citric acid of 0.05-0.12%, aseptic filtration, filtrate subpackage, rolls lid, makes beverage.
12. compound recipe snow chrysanthemum products as claimed in claim 5, it is characterized in that, the preparation method of described compound recipe snow chrysanthemum bagged tea comprises following steps:
1) get the snow chrysanthemum of formula ratio, Folium Stevlae Rebaudianae, at 0-6 DEG C, vacuum drying is less than 5% to water content, is ground into fine powder, crosses 60 mesh sieves for subsequent use;
2) lectuce tea powder getting formula ratio 50%-70% is broken into the coarse powder that granularity is 0.2-0.3mm, the Ampelopsis grossedentata branch and leaf of all the other Folium Ilicis and formula ratio, add 6-10 times amount, concentration is 55%-75% alcoholic solution reflux, extract, 1-2 time, each 1-2 hour, merge extractive liquid, filter, concentrating and being formed in relative density at 55-60 DEG C is the extractum of 1.20-1.30;
3) open parch pot, adjustment temperature is 75-85 DEG C, and stirring rod speed is 80-120 rev/min, put into after Folium Ilicis coarse powder stir-fries 10-20 minute, add step 1) snow inulin and Folium Stevlae Rebaudianae powder, and step 2) obtained extract extractum, after abundant mixing, mixture is put into sterilizing, drying equipment, first high temperature sterilize, be then cooled to rapidly less than 80 DEG C, cold drying, cross 80 mesh sieve granulate, subpackage, to obtain final product.
Compound recipe snow chrysanthemum product described in 13. any one of claim 1-12 has blood pressure lowering, blood sugar lowering and blood fat reducing three in preparation and falls application in functional product.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105767303A (en) * | 2016-03-09 | 2016-07-20 | 贵州省生物研究所 | Lonicera hypoglauca tea drink and preparation method thereof |
| CN105901230A (en) * | 2016-04-27 | 2016-08-31 | 济南舒美生物科技有限公司 | Compound health tea with efficacy of hyperuricemia inhibition |
| CN106173060A (en) * | 2016-07-12 | 2016-12-07 | 董雪 | A kind of Folium Chrysanthemi health tea and preparation method thereof |
| CN106690317A (en) * | 2016-11-11 | 2017-05-24 | 贵州黔贵天赐大健康集团有限公司 | Radix salviae miltiorrhizae composition and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103493940A (en) * | 2013-10-16 | 2014-01-08 | 四川好医生攀西药业有限责任公司 | Sanvitalia and tartary buckwheat composition and method for manufacturing same |
| CN103891960A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Tea made of plain coreopsis and red dates |
| CN103891961A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Plains coreopsis and schizonepeta tea |
-
2015
- 2015-03-18 CN CN201510117985.0A patent/CN104666643B/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103493940A (en) * | 2013-10-16 | 2014-01-08 | 四川好医生攀西药业有限责任公司 | Sanvitalia and tartary buckwheat composition and method for manufacturing same |
| CN103891960A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Tea made of plain coreopsis and red dates |
| CN103891961A (en) * | 2014-04-14 | 2014-07-02 | 张掖市亚兰生物科技有限公司 | Plains coreopsis and schizonepeta tea |
Non-Patent Citations (2)
| Title |
|---|
| 刘纳: "《不时不食》", 30 November 2013 * |
| 张育松 等: "《茶叶与健康》", 30 September 2009 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105767303A (en) * | 2016-03-09 | 2016-07-20 | 贵州省生物研究所 | Lonicera hypoglauca tea drink and preparation method thereof |
| CN105901230A (en) * | 2016-04-27 | 2016-08-31 | 济南舒美生物科技有限公司 | Compound health tea with efficacy of hyperuricemia inhibition |
| CN106173060A (en) * | 2016-07-12 | 2016-12-07 | 董雪 | A kind of Folium Chrysanthemi health tea and preparation method thereof |
| CN106690317A (en) * | 2016-11-11 | 2017-05-24 | 贵州黔贵天赐大健康集团有限公司 | Radix salviae miltiorrhizae composition and preparation method thereof |
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| CN104666643B (en) | 2018-12-04 |
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