CN101167875B - Traditional Chinese medicinal preparation for treating diabetes and its preparing process - Google Patents
Traditional Chinese medicinal preparation for treating diabetes and its preparing process Download PDFInfo
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- CN101167875B CN101167875B CN2007101564124A CN200710156412A CN101167875B CN 101167875 B CN101167875 B CN 101167875B CN 2007101564124 A CN2007101564124 A CN 2007101564124A CN 200710156412 A CN200710156412 A CN 200710156412A CN 101167875 B CN101167875 B CN 101167875B
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Abstract
The invention discloses a traditional Chinese medicine medicament for curing diabetic foot, and process for preparation. The invention comprises the following steps, 1) getting anoelica sinensis, and the anoelica sinensis is disintegrated into coarse powder in 5 to 20 orders, 4 to 10 times amount of 50 percent to 80 percent of grain alcohol is used as fluxing agent to percolate, and grain alcohole percolating liquid is gathered. 2) astragalus root, scrophularia root, cyathula root, red peony root, and honeysuckle flower are got to be added with water to decoct 2 times or 3 times, 1 hour or 2 hours each time, and which are combined with water to extract liquid, and the liquid stands for 24 hours to 48 hours, supernatant fluid is got to filter, and the filter liquor is compressed to concrete whose relative density is 1.20 to 1.25 (60 DEG C which is measured), the grain alcohol is added to lead alcohol concentration to reach 40 percent to 70 percent, and the concrete is refrigerated for 24 hours to 48 hours, and the concrete is filtered, the filter liquor and the alcohol percolating liquor are combined, and the grain alcohol is decompressed and recovered to concrete whose relative density is 1.16 to 1.30 (60 DEG C which is measured). 3) Getting the upper concrete, and granula, capsules, and tablets are made by adding findings into the concrete. The invention has the efficacies ofsupplementing Qi and nourishing Yin, and unblocking collaterals and relieving toxin. The drug for curing diabetic foot has the advantages of strong pertinence, better curative effect, small side effect, and excellent security.
Description
Technical field
The present invention relates to a kind of treatment diabetic foot Chinese medicine preparation and preparation method thereof.
Background technology
Diabetic foot claims diabetic acromelic gangrene, diabetic arterial occlusive disease again, belongs to that the traditional Chinese medical science " is quenched one's thirst ", the category of " necrosis ", and good sending out in limb end seen with lower limb more, shows as acrodynia, infection, ulcer, gangrene.It is one of diabetes severe complications, also is the diabetics lethal major reason that disables.In about 1.5 hundred million diabeticss in the whole world, will ulcer of foot or gangrene take place in a certain period of its life more than 15%.The amputation rate of diabetics is 15 times of ND.It is reported that domestic diabetic foot is occupied 12.4% of institute's diabetics, amputation rate is 7.3%, causes huge economy and burden on society, and is therefore very important to the prevention and the treatment of primary disease.Clinical practice in recent years shows that the Chinese medicine prevention diabetic foot has bigger advantage.
Summary of the invention
The purpose of this invention is to provide a kind of treatment diabetic foot Chinese medicine preparation and preparation method thereof.
Treatment diabetic foot Chinese medicine preparation prescription is: the Radix Astragali 6～10g, Radix Angelicae Sinensis 3～7g, Radix Scrophulariae 3～9g, Radix Cyathulae 6～10g, Radix Paeoniae Rubra 6～10g, Flos Lonicerae 6～10g, Radix Clematidis 3～7g.
Described Chinese medicine preparation is granule or capsule or tablet.
The preparation method of treatment diabetic foot Chinese medicine preparation may further comprise the steps:
1) getting Radix Angelicae Sinensis 3～7g, be ground into 5～20 purpose coarse powder, is that 50～80% ethanol carry out percolation with 4～10 times of mass percent concentrations, collects ethanol percolation liquid, standby;
2) get the Radix Astragali 6～10g, Radix Scrophulariae 3～9g, Radix Cyathulae 6～10g, Radix Paeoniae Rubra 6～10g, Flos Lonicerae 6～10g, Radix Clematidis 3～7g add 6～10 times of water gagings and decoct 2～3 times, each 1～2 hour, merge the water extract, left standstill 24～48 hours, get supernatant liquid filtering, filtrate is concentrated into the extractum of relative density 1.20～1.25, adding mass percent concentration and be 90～95% ethanol makes extractum contain the alcohol amount to reach 40～60%, cold preservation 24～48 hours, filter, merging filtrate and ethanol extract, decompression recycling ethanol is to the extractum of relative density 1.16～1.30, and is standby;
3) get above-mentioned extractum, adding the adjuvant total amount is the lactose and the dextrin of 1～2 times of extractum amount, adopts the boiling granulating method to make granule, makes granule; Or with the extractum vacuum drying, pulverize, add the starch mixing of mass percent 8%～12% dried cream powder amount, encapsulated, make capsule; Or with the extractum vacuum drying, pulverize, adding the adjuvant total amount is lactose, carboxymethyl starch sodium, microcrystalline Cellulose and the medicinal magnesium stearate of mass percent 8%～12% dried cream powder amount, tabletting makes tablet.
The mass percent of described lactose, carboxymethyl starch sodium, microcrystalline Cellulose, medicinal magnesium stearate is 2%～4% lactose, 3%～5% carboxymethyl starch sodium, 2%～3% microcrystalline Cellulose, 0.5%～1% medicinal magnesium stearate.
The present invention has supplementing QI and nourishing YIN, the effect of collateral dredging detoxifcation.This drug treatment of diabetic foot is with strong points, and curative effect is better, and side effect is little, and safety is good.
The specific embodiment
Reasonable recipe of the present invention, rigorous and scientific is effective Chinese medicine preparation.Radix Astragali tonifying Qi and lifting yang in the prescription, benefit is defended consolidating superficial resistance, promoting pus discharge and tissue regeneration strengthening; Chinese angelica blood supplementing is invigorated blood circulation, eliminating stasis to stop pain; Two medicines are harmonious, and QI invigorating and blood producing power is strong.Both all have effects such as microcirculation improvement, anticoagulant, antithrombotic simultaneously.The Radix Scrophulariae bitter but sweet flavor is salty, and is cold in nature, has clearing away heat and cooling blood, nourishing YIN to lower pathogenic fire, and the effect of detoxicating and resolving stagnation of pathogens, Radix Paeoniae Rubra is for letting out the diffusing product of row clearly, and being apt to relieve inflammation or internal heat, removing heat from blood is apt to blood circulation promoting and blood stasis dispelling and pain relieving again except that blood system is hot and suffocating.Flos Lonicerae is the product of removing summer-heat evacuation, and both kind removing summer-heat temperature again can dispelling wind and heat pathogens.The Radix Clematidis wind-damp dispelling, the meridian dredging is the key medicine of treatment anemofrigid-damp arthralgia numb limbs and tense tendons.The Radix Cyathulae blood circulation and removing stasis, easing joint movement, conducting blood to flow downwards.All medicine compatibilities are played supplementing QI and nourishing YIN altogether, the effect of collateral dredging detoxifcation.
The invention will be further described below by embodiment and toxicology and pharmacology experimental result.
Embodiment 1
Get Radix Angelicae Sinensis 330g, be ground into 10 purpose coarse powder, carry out percolation, collect ethanol percolation liquid with 8 times of amount 70% ethanol, standby; Other gets Radix Astragali 550g, Radix Scrophulariae 440g, Radix Cyathulae 550g, Radix Paeoniae Rubra 550g, Flos Lonicerae 550g, Radix Clematidis 330g adds 8 times of water gagings and decocts 2 times, each 1.5 hours, merge the water extract, left standstill 24 hours, get supernatant liquid filtering, filtrate is concentrated into the extractum of relative density 1.25 (60 ℃ of surveys), adding ethanol makes and contains alcohol amount and reach 50%, cold preservation 24 hours filters merging filtrate and ethanol extract, decompression recycling ethanol is to the extractum of relative density 1.16 (60 ℃ of surveys), add lactose 500g, dextrin 100g adopts the boiling granulating legal system to get granule, check, and packing promptly gets granule of the present invention.
Embodiment 2
Get Radix Angelicae Sinensis 210g and be ground into 10 purpose coarse powder, carry out percolation, collect ethanol percolation liquid with 8 times of amount 70% ethanol, standby; Other gets Radix Astragali 350g, Radix Scrophulariae 280g, Radix Cyathulae 350g, Radix Paeoniae Rubra 350g, Flos Lonicerae 350g, Radix Clematidis 210g adds 8 times of water gagings and decocts 2 times, each 1.5 hours, merge the water extract, left standstill 24 hours, get supernatant liquid filtering, filtrate is concentrated into the extractum of relative density 1.25 (60 ℃ of surveys), adds ethanol and makes and contain alcohol amount and reach 50%, cold preservation 24 hours, filter, merging filtrate and ethanol extract, decompression recycling ethanol is to the extractum of relative density 1.30 (60 ℃ of surveys), vacuum drying, pulverize, add the starch mixing of 10% dried cream powder amount, encapsulated, make 1000, promptly get capsule of the present invention.
Embodiment 3
Get Radix Angelicae Sinensis 210g and add heating and refluxing extraction 2 times in 8 times of amount 70% ethanol, each 1.5 hours, merge ethanol extract, standby; Other gets Radix Astragali 350g, Radix Scrophulariae 280g, Radix Cyathulae 350g, Radix Paeoniae Rubra 350g, Flos Lonicerae 350g, Radix Clematidis 210g adds 8 times of water gagings and decocts 2 times, each 1.5 hours, merge the water extract, left standstill 24 hours, get supernatant liquid filtering, filtrate is concentrated into the extractum of relative density 1.25 (60 ℃ of surveys), adds ethanol and makes and contain alcohol amount and reach 50%, cold preservation 24 hours, filter, merging filtrate and ethanol extract, decompression recycling ethanol is to the extractum of relative density 1.30 (60 ℃ of surveys), vacuum drying, pulverize, the lactose that adds 3% dried cream powder amount, 6% carboxymethyl starch sodium, 3% microcrystalline Cellulose, 0.5% medicinal magnesium stearate mixing tabletting is made 1000, promptly gets tablet of the present invention.
Toxicity and pharmacodynamics test
The present invention is to provide a kind of Chinese medicine preparation for the treatment of diabetic foot, for proving its therapeutic effect and safety, the granule that the method that the inventor uses to be provided in the foregoing description prepares has carried out toxicity and pharmacodynamics test, and result of study is as follows:
One, animal acute toxicity test data
Acute toxicity test in mice studies show that, irritates stomach (ig) the maximum granule of the present invention of limiting the quantity of, and do not see in seven days that mice has abnormal response, and promptly single-dose is difficult to measure the oral LD of granule mice of the present invention
50Granule of the present invention is peroral administration mtd test result show: mice is pressed (Cmax, maximum volume) behind 200g crude drug/kg gastric infusion, does not all have tangible toxic reaction,, no dead mouses in two weeks, in dissecting inspection do not see yet any unusually.
Two, function cures mainly relevant Pharmacodynamic test of active extract
Medicine of the present invention have set upright invigorate blood circulation, the effect of dispelling toxins and dredging collaterals, the treatment healthy energy loss of quenching one's thirst, phlegm-turbidity and blood stasis blood retardance meridians, the card that malicious heresy is made a bet, effectively Prevention and treatment for diabetic foot.Cause mice diabetic foot model with alloxan, with high, normal, basic three the dosage gastric infusions of granule of the present invention.The result shows: this product is obviously improved the mental status of diabetic mice, and the model mice blood sugar level after this product treated for 2 weeks is starkly lower than matched group simultaneously; Model mice serum fructosamine after 5 weeks of administration also significantly is lower than model group.In addition, experiment shows that this product also has certain effect for reducing fat.This product does not have obvious influence to the blood glucose of normal mouse simultaneously.
Claims (4)
1. a Chinese medicine preparation for the treatment of diabetic foot is characterized in that consisting of of its crude drug: the Radix Astragali 6～10g, Radix Angelicae Sinensis 3～7g, Radix Scrophulariae 3～9g, Radix Cyathulae 6～10g, Radix Paeoniae Rubra 6～10g, Flos Lonicerae 6～10g, Radix Clematidis 3～7g.
2. a kind of Chinese medicine preparation for the treatment of diabetic foot according to claim 1 is characterized in that described Chinese medicine preparation is granule or capsule or tablet.
3. preparation method for the treatment of the Chinese medicine preparation of diabetic foot according to claim 1 may further comprise the steps:
1) getting Radix Angelicae Sinensis 3～7g, be ground into 5～20 purpose coarse powder, is that 50～80% ethanol carry out percolation with 4～10 times of mass percent concentrations, collects ethanol percolation liquid, standby;
2) get the Radix Astragali 6～10g, Radix Scrophulariae 3～9g, Radix Cyathulae 6～10g, Radix Paeoniae Rubra 6～10g, Flos Lonicerae 6～10g, Radix Clematidis 3～7g add 6～10 times of water gagings and decoct 2～3 times, each 1～2 hour, merge the water extract, left standstill 24～48 hours, get supernatant liquid filtering, filtrate is concentrated into the extractum of relative density 1.20～1.25, adding mass percent concentration and be 90～95% ethanol makes extractum contain the alcohol amount to reach 40～60%, cold preservation 24～48 hours, filter, merging filtrate and ethanol extract, decompression recycling ethanol is to the extractum of relative density 1.16～1.30, and is standby;
3) get above-mentioned extractum, adding the adjuvant total amount is the lactose and the dextrin of 1～2 times of extractum amount, adopts the boiling granulating method to make granule, makes granule; Or with the extractum vacuum drying, pulverize, add the starch mixing of mass percent 8%～12% dried cream powder amount, encapsulated, make capsule; Or with the extractum vacuum drying, pulverize, adding the adjuvant total amount is lactose, carboxymethyl starch sodium, microcrystalline Cellulose and the medicinal magnesium stearate of mass percent 8%～12% dried cream powder amount, tabletting makes tablet.
4. a kind of preparation method for the treatment of the Chinese medicine preparation of diabetic foot according to claim 3, the mass percent that it is characterized in that described lactose, carboxymethyl starch sodium, microcrystalline Cellulose, medicinal magnesium stearate are 2%～4% lactose, 3%～5% carboxymethyl starch sodium, 2%～3% microcrystalline Cellulose, 0.5%～1% medicinal magnesium stearate.
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| CN2007101564124A CN101167875B (en) | 2007-10-25 | 2007-10-25 | Traditional Chinese medicinal preparation for treating diabetes and its preparing process |
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| CN2007101564124A CN101167875B (en) | 2007-10-25 | 2007-10-25 | Traditional Chinese medicinal preparation for treating diabetes and its preparing process |
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| CN101167875A CN101167875A (en) | 2008-04-30 |
| CN101167875B true CN101167875B (en) | 2011-04-13 |
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Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102319327B (en) * | 2011-10-11 | 2013-03-20 | 张俊瑕 | Traditional Chinese medicine for internally and externally treating diabetic foot |
| CN103784821B (en) * | 2012-11-02 | 2016-06-01 | 厉岩 | A kind of Chinese medicine composition treating diabetic foot |
| CN104095915A (en) * | 2014-08-06 | 2014-10-15 | 成都医路康医学技术服务有限公司 | Traditional Chinese medicine composition for treating diabetic foot |
| CN104352585A (en) * | 2014-11-11 | 2015-02-18 | 成都医路康医学技术服务有限公司 | Scorpion-containing traditional Chinese medicine composition for treating diabetic foot |
| JP7158831B2 (en) * | 2017-06-30 | 2022-10-24 | 小林製薬株式会社 | Tablet containing goshitsu processed material |
| CN107602351A (en) * | 2017-08-30 | 2018-01-19 | 芜湖杨燕制药有限公司 | Ethanol recovery process in a kind of traditional Chinese medicine diacolation process |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1907394A (en) * | 2005-08-03 | 2007-02-07 | 张成琼 | Medicine for treating diabetes foot |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1907394A (en) * | 2005-08-03 | 2007-02-07 | 张成琼 | Medicine for treating diabetes foot |
Non-Patent Citations (2)
| Title |
|---|
| 宋小梅等.中药内外兼治治疗糖尿病足38例.疑难病杂志4 2.2005,4(2),105-106. |
| 宋小梅等.中药内外兼治治疗糖尿病足38例.疑难病杂志4 2.2005,4(2),105-106. * |
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