CN107496567B - Traditional Chinese medicine preparation for treating diabetic foot disease and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for treating diabetic foot disease and preparation method thereof Download PDFInfo
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Abstract
A traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 8-12 parts of phellodendron, 2-6 parts of coptis chinensis, 7-15 parts of scutellaria baicalensis, 22-40 parts of fructus forsythiae, 12-26 parts of siegesbeckia orientalis, 15-25 parts of sedum sarmentosum, 27-34 parts of astragalus membranaceus and 14-25 parts of oriental wormwood. The invention aims to provide a traditional Chinese medicine preparation for treating diabetic foot, which has the advantages of strong pertinence, good safety, obvious curative effect and small toxic and side effects on the body of a patient.
Description
Technical Field
The invention belongs to the technical field of medical products, and particularly relates to a traditional Chinese medicine preparation for treating diabetic foot diseases and a preparation method thereof.
Background
Diabetes is a group of metabolic diseases characterized by hyperglycemia, and is one of epidemic diseases with high morbidity and serious harm in China. In diabetes, hyperglycemia occurring in a long time leads to chronic damage and dysfunction of various tissues, particularly eyes, kidneys, heart, blood vessels and nerves, and various diabetic complications are caused.
The diabetic foot refers to the disease state that the protective function of the lower limb of the foot of a diabetic patient is reduced due to neuropathy, and the microcirculation is disturbed due to insufficient arterial perfusion caused by macrovascular and microvascular lesions to generate ulcer and gangrene. The incidence rate of the traditional Chinese medicine is 15-20%, the traditional Chinese medicine is common in middle-aged and elderly people with long diabetes history and poor long-term blood sugar control, and the traditional Chinese medicine is one of the most common and serious complications of diabetes. Diabetic foot is characterized by numbness, coolness, decreased sensory ability, easy injury, difficult healing of superficial wound, etc. in the early stage, and is often easy to ignore. Once a wound, ulcer and infection of the foot or lower limb of a patient occur, if the wound, ulcer and infection is not treated in time, the wound is difficult to heal, a small wound can be not healed for a long time, the wound range is rapidly expanded and even necrotizes, the limb has to be amputated finally, and the infection can be induced to die. Causing great pain to patients and adding huge economic burden.
At present, western medicine mainly controls blood sugar, blood fat and blood pressure, improves blood circulation and peripheral neuropathy, uses antibiotic anti-infection treatment, and changes the dressing of ulcer wound surfaces. All are conservative symptomatic treatments, and the western medicine has limited treatment effect, single function and long service cycle, and is often required to be taken for life. The chemical medicine can also generate strong stimulation to the body, has large toxic and side effects, is easy to rebound, has poor safety and drug resistance, and increases the economic burden of patients.
With the progress of society, more and more people aim at the natural traditional Chinese medicine type safe medicine without toxic and side effects for treating diseases. The traditional Chinese medicine considers that the diabetic foot belongs to the field of gangrene in traditional Chinese medicine, and is mainly caused by deficiency of both qi and yin, obstruction of collaterals by blood stasis and failure of qi and blood to reach four limbs. Therefore, in order to better treat the diabetic foot and relieve the pain, the development and development of the traditional Chinese medicine composition prepared from natural traditional Chinese medicines, which has strong pertinence and timeliness, small toxic and side effects, good safety and obvious curative effect, is really necessary for the recovery of the diabetic foot.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine preparation for treating diabetic foot, which has the advantages of strong pertinence, good safety, obvious curative effect and small toxic and side effects on the body of a patient.
The technical scheme adopted by the invention for realizing the aim is as follows: a traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 8-12 parts of phellodendron, 2-6 parts of coptis chinensis, 7-15 parts of scutellaria baicalensis, 22-40 parts of fructus forsythiae, 12-26 parts of siegesbeckia orientalis, 15-25 parts of sedum sarmentosum, 27-34 parts of astragalus membranaceus and 14-25 parts of oriental wormwood.
A traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 10 parts of phellodendron, 5 parts of coptis chinensis, 10 parts of scutellaria baicalensis, 30 parts of forsythia, 20 parts of siegesbeckia orientalis, 20 parts of sedum sarmentosum, 30 parts of astragalus membranaceus and 20 parts of oriental wormwood.
A traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 9 parts of phellodendron, 3 parts of coptis, 12 parts of scutellaria, 40 parts of forsythia, 15 parts of siegesbeckia, 25 parts of sedum sarmentosum, 27 parts of astragalus and 22 parts of oriental wormwood.
A Chinese medicinal preparation for treating diabetic foot disease can be prepared into decoction, powder or capsule.
A Chinese medicinal preparation for treating diabetic foot diseases, wherein the decoction is prepared by the following steps:
step one, taking cortex phellodendri, coptis chinensis, scutellaria baicalensis, fructus forsythiae, herba siegesbeckiae, sedum sarmentosum, radix astragali and herba artemisiae capillaris according to the parts by weight of the raw materials, putting the cortex phellodendri, the coptis chinensis, the scutellaria baicalensis, the fructus forsythiae, the herba siegesbeckiae, the herba sarmentosi, the radix astragali and the herba artemisiae scopariae into a cooking container, adding 1000 parts of 500-;
step two, adding 500 parts of 300-;
and step three, uniformly mixing the filtrate a prepared in the step one and the filtrate b prepared in the step two to obtain the traditional Chinese medicine decoction.
In the first step, before the raw materials are boiled with water, the method further comprises a step of crushing the raw materials to 200-.
In the second step, the filter residue a is added with water and then is boiled, and the method also comprises the step of adding saccharifying enzyme and cellulose into the mixture of the filter residue a and the water and carrying out enzymolysis for 2-3h at the temperature of 45-55 ℃.
In the enzymolysis step, the addition amount of the saccharifying enzyme and the cellulase is 10-20U saccharifying enzyme added into each gram of filter residue a; 15-25U cellulase.
A traditional Chinese medicine preparation for treating diabetic foot diseases, the preparation method of the powder, comprises the following steps: according to the weight parts of the raw materials, the phellodendron, the coptis chinensis, the scutellaria baicalensis, the forsythia, the siegesbeckia orientalis, the sedum sarmentosum, the astragalus mongholicus and the oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes and uniformly mixed to obtain the traditional Chinese medicine powder.
A traditional Chinese medicine preparation for treating diabetic foot diseases, the preparation method of the capsule, comprises the following steps: according to the weight parts of the raw materials, phellodendron, coptis chinensis, scutellaria baicalensis, forsythia suspensa, siegesbeckia orientalis, sedum sarmentosum, astragalus mongholicus and oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes, uniformly mixed and filled into No. 1 capsules to obtain the traditional Chinese medicine capsules.
The invention has the advantages of
1. The traditional Chinese medicine preparation for treating diabetic foot provided by the invention is selected based on the understanding of traditional Chinese medicine on the pathogenesis of diabetic foot disease and the research on the pharmacological functions of various traditional Chinese medicines by combining with years of clinical experience and repeated adjustment. The Chinese medicinal preparation is prepared by uniquely selecting eight Chinese medicaments as raw materials, scientifically matching the Chinese medicaments, realizing the synergistic effect of the raw materials, complementing the advantages and bringing out the best in each other, and fundamentally improving and radically treating the diabetic foot. The astragalus and the forsythia which detoxify and dissipate stagnation are used as monarch drugs in the formula, and the functions of counteracting and tonifying, tonifying qi and strengthening exterior, expelling toxin, clearing heat and removing toxicity, and removing stasis and dissipating stagnation are achieved; cortex phellodendri, coptis chinensis, scutellaria baicalensis, herba artemisiae scopariae and sedum sarmentosum are taken as ministerial drugs, and the effects of clearing heat, eliminating dampness and detoxifying are achieved; the herba siegesbeckiae is used as adjuvant drug, and has the effects of dispelling pathogenic wind, removing dampness, clearing heat, dredging meridian passage and harmonizing the drugs. The medicines are compatible according to monarch, minister, assistant and guide medicines, all the medicines have synergistic effect, and the finished traditional Chinese medicine preparation has strong pertinence, good absorption degree, short treatment period and obvious drug effect, and has the curative effects of promoting blood circulation to remove blood stasis, removing blood stasis and resolving masses, diminishing inflammation and sterilizing, promoting qi circulation and expelling toxin and the like. Can rapidly eliminate red swelling, reduce wound surface, and relieve pain. The traditional Chinese medicine preparation has the advantages of overall pathogenic factor elimination and body resistance strengthening, reasonable formula and mild medication, and can fundamentally cure the diabetic foot disease and recover the foot function.
2. The traditional Chinese medicine preparation for treating diabetic foot disclosed by the invention can play a role to the greatest extent under the coordination and synergistic coordination based on the conditioning of the whole physical condition of a patient and based on the interaction between common traditional Chinese medicine component formulas. Clinical researches show that the traditional Chinese medicine preparation has an obvious effect of treating diabetic foot, local red swelling and hot pain symptoms of a patient gradually disappear after the traditional Chinese medicine preparation is taken, purulent secretion is obviously reduced, the area of a wound surface is continuously reduced, and the cure rate is over 75 percent after the traditional Chinese medicine preparation is matched with treatment of course medication. The effective rate of the medicine reaches more than 94 percent, and the medicine takes effect quickly. Meanwhile, the Chinese medicinal preparation is green and natural in raw materials, so the Chinese medicinal preparation has small toxic or side effect, good safety and reliability, no obvious adverse reaction even if the Chinese medicinal preparation is used for a long time, and relapse prevention is avoided after the Chinese medicinal preparation is stopped.
3. The traditional Chinese medicine preparation for treating diabetic foot is provided with the step of performing microwave treatment on the crushed raw material medicine in the preparation process of the decoction, and the microwave treatment can burst the surface layer of the material, change the mechanism structure, have loose and porous properties, and facilitate the raw material medicine powder to more fully activate and release the effective pharmacological components in the raw material medicine powder in the subsequent steps of boiling, enzymolysis and the like, so that the functional effect is more obvious.
4. The method comprises the steps of carrying out enzymolysis treatment on the filter residue after boiling and filtering, and through the enzymolysis treatment, under the synergistic action of saccharifying enzyme and cellulase in the solution, the structures such as cell walls of the raw material medicines can be damaged, so that the effective pharmacological ingredients in the cell structures are fully released, and polysaccharide substances in the cell structures are hydrolyzed into monosaccharide which is easy to absorb and released into the filtrate in a free state, so that the extraction and effective utilization rate of the raw material medicines are improved, and the effective pharmacological ingredients are absorbed by a human body.
Detailed Description
A traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 8-12 parts of phellodendron, 2-6 parts of coptis chinensis, 7-15 parts of scutellaria baicalensis, 22-40 parts of fructus forsythiae, 12-26 parts of siegesbeckia orientalis, 15-25 parts of sedum sarmentosum, 27-34 parts of astragalus membranaceus and 14-25 parts of oriental wormwood.
Preferably, the traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 10 parts of phellodendron, 5 parts of coptis chinensis, 10 parts of scutellaria baicalensis, 30 parts of forsythia, 20 parts of siegesbeckia orientalis, 20 parts of sedum sarmentosum, 30 parts of astragalus membranaceus and 20 parts of oriental wormwood.
Preferably, the traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 9 parts of phellodendron, 3 parts of coptis, 12 parts of scutellaria, 40 parts of forsythia, 15 parts of siegesbeckia, 25 parts of sedum sarmentosum, 27 parts of astragalus and 22 parts of oriental wormwood.
A Chinese medicinal preparation for treating diabetic foot disease can be prepared into decoction, powder or capsule.
A Chinese medicinal preparation for treating diabetic foot diseases, wherein the decoction is prepared by the following steps:
step one, taking cortex phellodendri, coptis chinensis, scutellaria baicalensis, fructus forsythiae, herba siegesbeckiae, sedum sarmentosum, radix astragali and herba artemisiae capillaris according to the parts by weight of the raw materials, putting the cortex phellodendri, the coptis chinensis, the scutellaria baicalensis, the fructus forsythiae, the herba siegesbeckiae, the herba sarmentosi, the radix astragali and the herba artemisiae scopariae into a cooking container, adding 1000 parts of 500-;
step two, adding 500 parts of 300-;
and step three, uniformly mixing the filtrate a prepared in the step one and the filtrate b prepared in the step two to obtain the traditional Chinese medicine decoction.
In the first step, before the raw materials are boiled with water, the method further comprises a step of crushing the raw materials to 200-.
In the second step, the filter residue a is added with water and then is boiled, and the method also comprises the step of adding saccharifying enzyme and cellulose into the mixture of the filter residue a and the water and carrying out enzymolysis for 2-3h at the temperature of 45-55 ℃.
In the enzymolysis step, the addition amount of the saccharifying enzyme and the cellulase is 10-20U saccharifying enzyme added into each gram of filter residue a; 15-25U cellulase.
A traditional Chinese medicine preparation for treating diabetic foot diseases, the preparation method of the powder, comprises the following steps: according to the weight parts of the raw materials, the phellodendron, the coptis chinensis, the scutellaria baicalensis, the forsythia, the siegesbeckia orientalis, the sedum sarmentosum, the astragalus mongholicus and the oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes and uniformly mixed to obtain the traditional Chinese medicine powder.
A traditional Chinese medicine preparation for treating diabetic foot diseases, the preparation method of the capsule, comprises the following steps: according to the weight parts of the raw materials, phellodendron, coptis chinensis, scutellaria baicalensis, forsythia suspensa, siegesbeckia orientalis, sedum sarmentosum, astragalus mongholicus and oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes, uniformly mixed and filled into No. 1 capsules to obtain the traditional Chinese medicine capsules.
According to the formula of the traditional Chinese medicine preparation, the astragalus and the fructus forsythiae are used as monarch drugs, the golden cypress, the coptis chinensis, the scutellaria baicalensis, the herba artemisiae scopariae and the sedum sarmentosum are used as ministerial drugs, the siegesbeckia herba is used as an assistant and guide drug, and the monarch, the assistant and guide have synergistic effects, so that the traditional Chinese medicine preparation has a good curative effect of radically treating the diabetic foot disease.
Wherein Huang Qi is sweet in nature and slightly warm. It enters lung, spleen, liver and kidney meridians. Has the effects of invigorating qi, consolidating superficial resistance, inducing diuresis, expelling toxin, expelling pus, healing sore, promoting granulation, inducing diuresis, and relieving swelling, and can significantly improve immunity.
Lian Qiao, with cool nature and bitter taste, enters heart, liver and gallbladder meridians. Has the effects of clearing away heat and toxic materials, eliminating stagnation, relieving swelling, removing blood stasis, and resolving hard mass.
Huang Bai is bitter in taste and cold in nature. It enters kidney meridian, bladder meridian and large intestine meridian. Has effects in purging pathogenic fire, eliminating dampness, clearing away heat and toxic materials, eliminating sore, relieving pain, inhibiting bacteria, and relieving inflammation.
Huang Lian is bitter in taste and cold in nature. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. Has effects of removing toxic substance, treating sore, clearing heat, eliminating dampness, relieving exterior syndrome, and purging pathogenic fire. Also has significant anti-inflammatory and antidotal effects.
Baikal skullcap root, bitter in taste and cold in nature. It enters lung, gallbladder, spleen, large intestine and small intestine meridians. Has effects in clearing away heat, eliminating dampness, purging pathogenic fire, removing toxic materials, stopping bleeding, and lowering blood pressure.
Yin Chen is bitter in taste, pungent in flavor and slightly cold in nature. It is entered into spleen, stomach, liver and gallbladder meridians. Has effects in clearing away heat, promoting diuresis, removing jaundice, relieving constipation, promoting urination, relieving fever, protecting liver, promoting bile flow, removing toxic materials, inhibiting bacteria, and improving blood flow microcirculation.
Sedum sarmentosum Bunge is sweet in taste and cool in nature. Has the functions of eliminating dampness, eliminating jaundice, clearing away heat and toxic material.
Siegesbeckiae herba has effects of dispelling cold, eliminating dampness, clearing away heat and toxic materials, dredging meridian passage, resisting bacteria and malaria.
The eight traditional Chinese medicines are green and natural in material selection, so the medicine has small toxic and side effect, low cost, high cure rate, strong drug effect, no pollution in production, good safety and reliability, no adverse reaction such as drug dependence and the like even if the medicine is used for a long time, and no relapse is easy to occur after the medicine is stopped. The preparation method of the medicine is simple and easy to control, has low cost and is worth popularizing.
Example 1:
the traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 10 parts of phellodendron, 5 parts of coptis chinensis, 10 parts of scutellaria baicalensis, 30 parts of forsythia, 20 parts of siegesbeckia orientalis, 20 parts of sedum sarmentosum, 30 parts of astragalus membranaceus and 20 parts of oriental wormwood.
A method for preparing a Chinese medicinal decoction for treating diabetic foot diseases comprises the following steps:
step one, taking cortex phellodendri, coptis chinensis, scutellaria baicalensis, fructus forsythiae, herba siegesbeckiae, sedum sarmentosum, radix astragali and herba artemisiae scopariae according to the parts by weight of the raw materials, crushing the raw materials to 200 meshes, then putting the raw materials into a microwave dryer, carrying out microwave treatment for 200s under 600W microwave power, then transferring the raw materials into a cooking container, adding 500 parts of water, boiling the raw materials for 30min under normal pressure, and then filtering to obtain filtrate a and filter residue a for later use;
step two, adding 400 parts of water into the filter residue a obtained in the step one, then adding 15U of saccharifying enzyme and 20U of cellulase into the mixture of the filter residue a and the water according to the proportion of adding 15U of saccharifying enzyme and 20U of cellulase into each gram of filter residue a, carrying out enzymolysis for 3 hours at the temperature of 50 ℃, then boiling for 40 minutes at normal pressure, and carrying out filtration treatment to obtain filtrate b and filter residue b for later use;
and step three, uniformly mixing the filtrate a prepared in the step one and the filtrate b prepared in the step two to obtain the traditional Chinese medicine decoction.
Example 2:
the traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 9 parts of phellodendron, 3 parts of coptis, 12 parts of scutellaria, 40 parts of forsythia, 15 parts of siegesbeckia, 25 parts of sedum sarmentosum, 27 parts of astragalus and 22 parts of oriental wormwood.
A preparation method of a traditional Chinese medicine preparation powder for treating diabetic foot diseases comprises the following steps: according to the weight parts of the raw materials, the phellodendron, the coptis chinensis, the scutellaria baicalensis, the forsythia, the siegesbeckia orientalis, the sedum sarmentosum, the astragalus mongholicus and the oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes and uniformly mixed to obtain the traditional Chinese medicine powder.
Example 3:
the traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 8 parts of phellodendron, 6 parts of coptis chinensis, 15 parts of scutellaria baicalensis, 22 parts of fructus forsythiae, 12 parts of siegesbeckia orientalis, 15 parts of sedum sarmentosum, 34 parts of astragalus mongholicus and 14 parts of oriental wormwood.
A traditional Chinese medicine preparation for treating diabetic foot diseases, the preparation method of the capsule, comprises the following steps: according to the weight parts of the raw materials, phellodendron, coptis chinensis, scutellaria baicalensis, forsythia suspensa, siegesbeckia orientalis, sedum sarmentosum, astragalus mongholicus and oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes, uniformly mixed and filled into No. 1 capsules to obtain the traditional Chinese medicine capsules.
Example 4:
the traditional Chinese medicine preparation for treating diabetic foot diseases is prepared from the following raw materials in parts by weight: 12 parts of phellodendron, 2 parts of coptis chinensis, 7 parts of scutellaria baicalensis, 40 parts of fructus forsythiae, 26 parts of siegesbeckia orientalis, 20 parts of sedum sarmentosum, 30 parts of astragalus mongholicus and 25 parts of oriental wormwood.
A method for preparing a Chinese medicinal decoction for treating diabetic foot diseases comprises the following steps:
step one, taking cortex phellodendri, coptis chinensis, scutellaria baicalensis, fructus forsythiae, herba siegesbeckiae, sedum sarmentosum, radix astragali and herba artemisiae scopariae according to the parts by weight of the raw materials, crushing the raw materials to 300 meshes, then putting the raw materials into a microwave dryer, carrying out microwave treatment for 150s under the microwave power of 900W, then transferring the raw materials into a cooking container, adding 1000 parts of water, boiling the raw materials for 40min at normal pressure, and then filtering the raw materials to obtain filtrate a and filter residue a for later use;
step two, adding 500 parts of water into the filter residue a obtained in the step one, then adding saccharifying enzyme and cellulase into a mixture of the filter residue a and the water according to the proportion of adding 20U saccharifying enzyme and 15U cellulase into each gram of the filter residue a, carrying out enzymolysis for 2 hours at the temperature of 55 ℃, then boiling for 40 minutes at normal pressure, and carrying out filtration treatment to obtain filtrate b and filter residue b for later use;
and step three, uniformly mixing the filtrate a prepared in the step one and the filtrate b prepared in the step two to obtain the traditional Chinese medicine decoction.
Clinical trial
In order to better verify the curative effect of the traditional Chinese medicine preparation, the traditional Chinese medicine preparation for treating diabetic foot disease, which is prepared by adopting the raw material proportioning in the embodiment of the invention, is subjected to clinical observation and research to further illustrate the curative effect of the traditional Chinese medicine preparation for treating diabetic foot disease.
Clinical data:
1. subject: a total of 150 patients diagnosed with diabetic foot disease; the age distribution is 18-80 years old;
2. the treatment method comprises the following steps: taking the traditional Chinese medicine preparation decoction or capsule used by the invention; the decoction is taken by oral administration once in the morning and at night every day, 200 mL of the decoction is taken each time, and 30 days is a course of treatment; the capsule is administered 6 granules each time 3 times a day with warm water for 30 days as a treatment course.
3. Treatment evaluation criteria:
firstly, effect is shown: the symptoms of local red swelling and hot pain disappear, purulent secretion is obviously reduced, and the area of the wound surface is reduced by more than 50 percent.
Secondly, effectively: the symptoms of local red swelling and hot pain are reduced, purulent secretion is reduced, and the area of the wound surface is reduced by less than 50%.
③, invalid: the wound surface and its periphery are not obviously changed.
4. The treatment effect is as follows: the treatment efficiency of 150 patients treated by the invention is up to 94.6% and the significant efficiency is up to 76% in 114 cases, 28 cases and 8 cases of effective and ineffective patients. The results show that the traditional Chinese medicine formula disclosed by the invention is reasonable in formula and has a remarkable curative effect on treating diabetic foot diseases.
5. Clinical treatment typical cases:
case 1
Wu Yi, male, 79 years old, Fumin Dai Jie, Ru Zhou, suffered from diabetes for 7 years, and had ulceration of the right foot for 4 months. Red and swollen right foot, high local skin temperature, deficient second and third toes, exposed stump, unclear border and massive exudation of purulent substances; the bottom of the foot can be seen with 7 × 4cm and 5 × 3cm skin ulceration openings, the boundary is clear, the tendon can be seen to be exposed, and a small amount of purulent substances can seep out; the inner sides of the dorsum of the foot and the root of the big toe are respectively provided with a skin ulceration, the boundaries are unclear, and a small amount of purulent substances seep out. The skin of the lower limbs is thin, vellus hairs are detached, bilateral dorsal artery pulsation is weakened, ankle reflex of the lower limbs is normal, and acupuncture pain sensation, vibration sensation, pressure sensation and temperature sensation are slightly reduced. The diagnosis is diabetic foot disease grade 4. The oral hypoglycemic drug is used for controlling the blood sugar to reach the standard, and is matched with the conventional local debridement and the physiological saline wet dressing to resist infection conventionally. When the traditional Chinese medicine capsule for treating diabetic foot diseases is taken, the size of the capsule is No. 1, 6 capsules are taken each time and 3 times a day, the capsule is taken with warm water, 1 month of continuous treatment is achieved, purulent secretion is obviously reduced, granulation tissues grow greatly, and the wound surface is reduced by 62%.
Case 2
When a certain person is a woman in 61 years old and a person in village in villages, scorch, ruzhou, suffers from diabetes for 3 years, the right foot is red, swollen and hot, the right foot is 20 days, the hallux valgus of the right foot is 10 days, the middle edema of the right foot, the top skin of the thumb of the right foot is black and atrophied, the inner side of the ulcer surface of 3 multiplied by 6cm can be seen, a large amount of necrotic tissues remain, and foul odor is volatilized. Diabetic foot disease was diagnosed as grade 4. Insulin and oral hypoglycemic drugs are used for controlling blood sugar to reach the standard, and the insulin and the oral hypoglycemic drugs are matched with local conventional debridement and physiological saline wet dressing to achieve conventional anti-infection. When the traditional Chinese medicine decoction for treating diabetic foot diseases is taken, 250 milliliters of decoction is taken each time, the decoction is taken warmly 2 times a day, 2 months of continuous treatment are carried out, purulent secretion is obviously reduced, swelling and heat pain of feet disappear, the ulcer surface is reduced by 57 percent in 2 months, and the foot ulcer is healed in 4 months.
The above description is only exemplary of the present invention and should not be taken as limiting, and any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine preparation for treating diabetic foot diseases is characterized by being prepared from the following raw materials in parts by weight: 8-12 parts of phellodendron, 2-6 parts of coptis chinensis, 7-15 parts of scutellaria baicalensis, 22-40 parts of fructus forsythiae, 12-26 parts of siegesbeckia orientalis, 15-25 parts of sedum sarmentosum, 27-34 parts of astragalus membranaceus and 14-25 parts of oriental wormwood.
2. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of phellodendron, 5 parts of coptis chinensis, 10 parts of scutellaria baicalensis, 30 parts of forsythia, 20 parts of siegesbeckia orientalis, 20 parts of sedum sarmentosum, 30 parts of astragalus membranaceus and 20 parts of oriental wormwood.
3. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 1, which is prepared from the following raw materials in parts by weight: 9 parts of phellodendron, 3 parts of coptis, 12 parts of scutellaria, 40 parts of forsythia, 15 parts of siegesbeckia, 25 parts of sedum sarmentosum, 27 parts of astragalus and 22 parts of oriental wormwood.
4. The Chinese medicinal preparation for treating diabetic foot disease according to any one of claims 1 to 3, which is characterized in that: can be made into decoction, powder or capsule.
5. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 4, wherein the preparation method of the decoction comprises the following steps:
step one, taking cortex phellodendri, coptis chinensis, scutellaria baicalensis, fructus forsythiae, herba siegesbeckiae, sedum sarmentosum, radix astragali and herba artemisiae capillaris according to the parts by weight of the raw materials, putting the cortex phellodendri, the coptis chinensis, the scutellaria baicalensis, the fructus forsythiae, the herba siegesbeckiae, the herba sarmentosi, the radix astragali and the herba artemisiae scopariae into a cooking container, adding 1000 parts of 500-;
step two, adding 500 parts of 300-;
and step three, uniformly mixing the filtrate a prepared in the step one and the filtrate b prepared in the step two to obtain the traditional Chinese medicine decoction.
6. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 5, characterized in that: in the first step, before the raw materials are boiled with water, the method further comprises a step of crushing the raw materials to 200-.
7. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 5, characterized in that: in the second step, the filter residue a is added with water and then is boiled, and the method also comprises the step of adding saccharifying enzyme and cellulose into the mixture of the filter residue a and the water and carrying out enzymolysis for 2-3h at the temperature of 45-55 ℃.
8. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 7, characterized in that: in the enzymolysis step, the addition amount of the saccharifying enzyme and the cellulase is 10-20U saccharifying enzyme added into each gram of filter residue a; 15-25U cellulase.
9. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 4, wherein the preparation method of the powder comprises the following steps: according to the weight parts of the raw materials, the phellodendron, the coptis chinensis, the scutellaria baicalensis, the forsythia, the siegesbeckia orientalis, the sedum sarmentosum, the astragalus mongholicus and the oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes and uniformly mixed to obtain the traditional Chinese medicine powder.
10. The traditional Chinese medicine preparation for treating diabetic foot disease according to claim 4, wherein the preparation method of the capsule comprises the following steps: according to the weight parts of the raw materials, phellodendron, coptis chinensis, scutellaria baicalensis, forsythia suspensa, siegesbeckia orientalis, sedum sarmentosum, astragalus mongholicus and oriental wormwood are respectively dried, crushed to the particle size of 100-200 meshes, uniformly mixed and filled into No. 1 capsules to obtain the traditional Chinese medicine capsules.
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