CN103784821B

CN103784821B - A kind of Chinese medicine composition treating diabetic foot

Info

Publication number: CN103784821B
Application number: CN201210431115.7A
Authority: CN
Inventors: 厉岩
Original assignee: Individual
Current assignee: Individual
Priority date: 2012-11-02
Filing date: 2012-11-02
Publication date: 2016-06-01
Anticipated expiration: 2032-11-02
Also published as: CN103784821A

Abstract

The present invention discloses a kind of Chinese medicine composition treating diabetic foot, belong to Chinese medicine composition, it is made up according to certain weight proportion of the red sage root, Semen Persicae (parched), Ligusticum wallichii, the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Spine of Chinese Honeylocust, Stem of Sargentgloryvine, radix scrophulariae, Radix Rehmanniae, the root of herbaceous peony, leech, Rhizoma Atractylodis (parched), the radix paeoniae rubrathe, Rhizome of Glabrous Greenbrier, Radix Glycyrrhizae, the present invention has that good effect, the course for the treatment of be short, curative ratio height, cost is low, is worth promoting clinically.

Description

A kind of Chinese medicine composition treating diabetic foot

Technical field

The present invention relates to a kind of Chinese medicine composition, it is specifically related to a kind of Chinese medicine composition treating diabetic foot.

Background technology

Diabetic foot refers to that diabetic subject causes the destruction of lower limb infection, ulceration and (or) deep tissue due to diabetic angiopathy and (or) the neural factor such as pathology and infection. Diabetic foot often shows as xerosis cutis on pin, poor flexibility, and color of the leather is dimmed, numb limbs and tense tendons, perceptual difference, engender shouting pain, skelagia after long-time walking, when progressively developing into rest also bitterly, arteriopalmus weakens or disappears, serious caused skin ulceration, infection suppurates, even downright bad. Treatment diabetic foot, to put prevention first, avoids foot to damage as possible, and common general treatment means is: strict glycemic control, eliminates the Hazard Factor causing blood vessel pathology, such as hypertension, and hyperlipidemia etc. At present diabetic foot many uses microbiotic is treated, but the antibiotic therapy cycle is long, toxic side effect; Also there is the Chinese medicine for this disease, but Chinese medicine formula is complicated and onset is slow.

Summary of the invention

It is an object of the invention to the deficiency in order to solve in above-mentioned technology, it is provided that good effect, the course for the treatment of be short, curative ratio height, a kind of Chinese medicine composition treating glycosuria foot that cost is low.

The present invention selects the red sage root, Semen Persicae (parched), Ligusticum wallichii, the Radix Astragali, Radix Codonopsis, Rhizoma Atractylodis Macrocephalae (parched), Spine of Chinese Honeylocust, Stem of Sargentgloryvine, radix scrophulariae, Radix Rehmanniae, the root of herbaceous peony, leech, Rhizoma Atractylodis (parched), the radix paeoniae rubrathe, Rhizome of Glabrous Greenbrier, Radix Glycyrrhizae to combine, each efficacy of drugs is made to produce synergy, have dredging the meridian, invigorating blood circulation is become silted up, effect of clearing heat and detoxicating, swelling and pain relieving, logical qi and blood circulation promotion, promoting regeneration of tissue for astringency such that it is able to effectively treat diabetic foot.

Wherein each raw material effect in formula:

The red sage root: be the dry root and rhizome of the dicotyledons Labiatae salvia red sage root. Bitter, slightly warm in nature. Enter the heart, Liver Channel. Having promoting blood circulation to remove blood stasis, pain relieving disappears carbuncle, effect of nourishing blood to tranquillize the mind. For improving microcirculation, promote reparation and the regeneration of tissue, alleviate local extravasated blood, improve blood circulation, shorten healing time.

Semen Persicae (parched): be the dry mature seed of rosaceous plant peach or mountain peach. Bitter, sweet, property is put down. The thoughts of returning home, liver, large intestine channel. The effect with promoting blood circulation to remove blood stasis, for vasodilator, suppresses blood coagulation and haemolysis, improves blood flow retardance, blood obstacle.

Ligusticum wallichii: be the rhizome of samphire Ligusticum wallichii. Taste is pungent, warm in nature. Return liver, courage, pericardium warp. There is promoting blood circulation to remove blood stasis, activating QI to alleviate the depression, effect of wind-expelling pain-stopping.

The Radix Astragali: be the root of leguminous plants Radix Astagali or Radix Astragali. Taste is sweet, slightly warm in nature. Return lung, spleen, liver, kidney channel. Having holder sore myogenic, inducing diuresis to remove edema, effect of expelling pus and toxin by strengthening QI, the astragalus polysaccharides in the Radix Astragali can also be used for strengthening immunity.

Radix Codonopsis: be the root of Campanulaceae Radix Codonopsis, element flower Radix Codonopsis, radix codonpsis tangshen, pipe flower Radix Codonopsis, C. subglobosa, C. canescens. Taste is sweet, and property is put down, micro-acid. Return spleen, lung channel. The effect with nourishing blood to promote the production of body fluid, for suppressing thrombus in vivo to be formed, reduces hyperlipidaemia, and expansion surrounding blood vessel reduces blood pressure.

Rhizoma Atractylodis Macrocephalae (parched): be the rhizome of the feverfew bighead atractylodes rhizome. Bitter, sweet, warm in nature. Return spleen, stomach warp. There is eliminating dampness Li Shui, effect of strengthening superficial resistance to stop perspiration, for hypoglycemic, extend the clotting time, anticoagulant.

Spine of Chinese Honeylocust: be the quil of leguminous plants Chinese honey locust. Taste is pungent, warm in nature. Return lung, Liver Channel. There is promoting blood circulation by removing wind, effect of detumescence and apocenosis.

Stem of Sargentgloryvine: be the stem of plants of Lardizabalaceae Stem of Sargentgloryvine. Bitter, property is put down. Enter liver, large intestine channel. There is dispersing swelling and dissipating binds, effect of vital energy regualting and blood circulation-promoting.

Radix scrophulariae: be the dry root of dicotyledons scrophulariaceae radix scrophulariae. Taste is sweet, bitter, salty; Cold nature. Return lung, stomach, kidney channel. The effect with clearing heat and cooling blood, for expanding lower limb vascular.

Radix Rehmanniae: be the root of dicotyledons medicine scrophulariaceae rehmannia glutinosa plant or bosom celebrating glutinous rehmannia. Taste sweetness and bitterness, cool in nature. Enter the heart, liver, kidney channel. The effect with clearing heat and cooling blood, for promoting blood coagulation, reduce blood sugar.

The root of herbaceous peony: be the root of dicotyledons medicine ranunculaceae plant Chinese herbaceous peony (cultivar). Bitter acid, cool in nature. Enter liver, the spleen channel. There is pain relieving of nourishing blood, clear and coherent blood vessels, effect of subduing inflammation.

Leech: be the dry entirety of leech section animal leech, leech or willow leaf leech. Taste is salty, bitter, and property is put down, nontoxic. Return Liver Channel. The effect with hemostasis of dispelling, for inhibition thrombosis.

Rhizoma Atractylodis (parched): being the dry rhizome of feverfew thatch rhizoma atractylodis or Atractylis chinensis, taste is pungent, bitter, warm in nature. Return spleen, stomach, Liver Channel. There is loose swollen effect of dispeling the wind.

The radix paeoniae rubrathe: be the dry root of the ranunculaceae plant radix paeoniae rubrathe or the river radix paeoniae rubrathe. Bitter, cold nature. Return Liver Channel. The effect with row stasis of blood pain relieving, the detumescence of cool blood, for inhibition thrombosis and platelet aggregation.

Rhizome of Glabrous Greenbrier: be the dry rhizome of dicotyledons medicine liliaceous plant smilacis glabra. Taste is sweet light, and property is put down. Return liver, stomach, the spleen channel. There is effect of clearing damp removing toxic substances.

Radix Glycyrrhizae: be the dry root and rhizome of glycyrrhizic legume, glycyrrhiza inflate bat or glycyrrhiza glabra. Taste is sweet, and property is put down. The thoughts of returning home, lung, spleen, stomach warp. Have clearing heat and detoxicating, alleviate effect of toxicity.

Medicine material consumption of the present invention is groped to sum up in a large number through contriver and is drawn, each raw material dosage is for all to have good curative effect in following weight parts scope: red sage root 15-25 part, Semen Persicae (parched) 7-17 part, Ligusticum wallichii 7-17 part, Radix Astragali 40-60 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 15-25 part, Spine of Chinese Honeylocust 20-28 part, Stem of Sargentgloryvine 20-28 part, radix scrophulariae 10-20 part, Radix Rehmanniae 15-25 part, root of herbaceous peony 10-20 part, leech 5-15 part, Rhizoma Atractylodis (parched) 10-20 part, radix paeoniae rubrathe 10-20 part, Rhizome of Glabrous Greenbrier 15-25 part, Radix Glycyrrhizae 5-13 part.

Its optimum weight proportioning component: the red sage root 20 parts, Semen Persicae (parched) 12 parts, Ligusticum wallichii 12 parts, the Radix Astragali 50 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Spine of Chinese Honeylocust 24 parts, Stem of Sargentgloryvine 24 parts, radix scrophulariae 15 parts, Radix Rehmanniae 20 parts, the root of herbaceous peony 15 parts, leech 10 parts, Rhizoma Atractylodis (parched) 15 parts, the radix paeoniae rubrathe 15 parts, Rhizome of Glabrous Greenbrier 20 parts, Radix Glycyrrhizae 9 parts.

Medicine of the present invention can adopt the ordinary method of Chinese medicine preparation to be prepared into powder. Specifically these bulk drug grinding powders can be mixed and make powder, put into hot water or directly water decoct into decoction bubble pin.

Medicine of the present invention has dredging the meridian, invigorating blood circulation is become silted up, effect of clearing heat and detoxicating, swelling and pain relieving, logical qi and blood circulation promotion, promoting regeneration of tissue for astringency, and good effect, curative ratio height, cost is low. Through 100 example system clinical observations, experimental result add up, symptom relatively the lighter only use a course for the treatment of of the present invention, always have efficiency 92%, symptom relatively severe one use two courses for the treatment of, always have efficiency 97%.

Embodiment

Embodiment one, the red sage root 15 parts, Semen Persicae (parched) 7 parts, Ligusticum wallichii 7 parts, the Radix Astragali 40 parts, Radix Codonopsis 10 parts, Rhizoma Atractylodis Macrocephalae (parched) 15 parts, Spine of Chinese Honeylocust 20 parts, Stem of Sargentgloryvine 20 parts, radix scrophulariae 10 parts, Radix Rehmanniae 15 parts, the root of herbaceous peony 10 parts, leech 5 parts, Rhizoma Atractylodis (parched) 10 parts, the radix paeoniae rubrathe 10 parts, Rhizome of Glabrous Greenbrier 15 parts, Radix Glycyrrhizae 5 parts.

Embodiment two, the red sage root 20 parts, Semen Persicae (parched) 12 parts, Ligusticum wallichii 12 parts, the Radix Astragali 50 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Spine of Chinese Honeylocust 24 parts, Stem of Sargentgloryvine 24 parts, radix scrophulariae 15 parts, Radix Rehmanniae 20 parts, the root of herbaceous peony 15 parts, leech 10 parts, Rhizoma Atractylodis (parched) 15 parts, the radix paeoniae rubrathe 15 parts, Rhizome of Glabrous Greenbrier 20 parts, Radix Glycyrrhizae 9 parts.

Embodiment three, the red sage root 25 parts, Semen Persicae (parched) 17 parts, Ligusticum wallichii 17 parts, the Radix Astragali 60 parts, Radix Codonopsis 20 parts, Rhizoma Atractylodis Macrocephalae (parched) 25 parts, Spine of Chinese Honeylocust 28 parts, Stem of Sargentgloryvine 28 parts, radix scrophulariae 20 parts, Radix Rehmanniae 25 parts, the root of herbaceous peony 20 parts, leech 15 parts, Rhizoma Atractylodis (parched) 20 parts, the radix paeoniae rubrathe 20 parts, Rhizome of Glabrous Greenbrier 25 parts, Radix Glycyrrhizae 13 parts.

Here is the clinical statistics data that patient uses medicine of the present invention:

One, physical data

Accept outpatient service patient totally 100 example for medical treatment, the wherein male sex 64 example, women 36 example, M-F 1.8:1,58 years old mean age.

Two, Case definition

Tcm diagnosis standard is with reference to " guideline of clinical investigations of traditional Chinese medical science new drug treatment diabetes ". Diabetic foot Chinese medical discrimination somatotype:

Clinical manifestation: acromelic gangrene, color is turned black, and surface of a wound exudate is less, and limbs are sent out cool to be afraid of cold, and pain numbness is insensitive, ochrodermia, thin white fur of tongue, and tongue is dark red, and deep-thready pulse is weak.

Three, using method:

Powder is put in tub or enamel basin, puts into lavipeditum 20��30 minutes when hot water is cooled to 37 DEG C ~ 39 DEG C after cleaning by warm water by patient with diabetic feet, can constantly convert and add boiling water and increase to temperature required when water is cool, and bubble future trouble foot dries naturally, every day twice, each one dose. 30 days course for the treatment of.

The scope of application: the present invention is mainly suitable for the decubation that diabetic foot has controlled by the 1-3 level in grading Wagner staging and more than 3 grades acute infections.

Taboo item: (1) should not steep pin after meal half an hour, the bubble pin time is no more than half an hour.

(2) foot has infection or hemorrhage situation, will forbid bubble pin.

Four, efficacy assessment standard

Criterion of therapeutical effect is with reference to " diagnosis and treatment of diabetic foot and related complication ".

Cure: the gangrene surface of a wound heals completely, has formed crust or scar.

Taking a turn for the better: gangrene merocrine secretion thing obviously reduces, gangrene, necrotic tissue major part come off or part granulation new life, and the surface of a wound significantly reduces.

Invalid: the gangrene surface of a wound is without obviously reducing, and secretory product is without obvious minimizing, and gangrene local is without noticeable change or deterioration.

Five, treatment result statistics

Wherein: always have efficiency=curative ratio+improvement rate

Model case and curative effect:

Case one, patient Liu, female, 56 years old, before 2 years, urine sugar was positive, oral antidiabetic drug, and before year, during lower limb lifting, pedal skin is pale, and then in red-purple when lower limb are sagging, foot is sent out cool, and pulsation of foot dorsal artery weakens, and outpatient service is made a definite diagnosis as diabetic foot. Through patient with being intended to coordinate when continuing medicine for oral administration external application bubble course for the treatment of of pin, clinical symptom completely dissolve, does not recur again.

Case two, patient Song, man, 62 years old, suffers from diabetes 7 years. Recently, often there is numb shouting pain, meets that cold pain increases the weight of in both feet toe, blackening in toenail, and xerosis cutis, poor flexibility on pin, color of the leather is dimmed, numb limbs and tense tendons, perceptual difference, long-time walking skelagia symptom afterwards. Coordinate external application bubble two courses for the treatment of of pin when continuing medicine for oral administration, toe erythrosis moistens, and clinical symptom completely dissolve, does not recur again.

Case three, patient Zhu, man, 68 years old, suffers from diabetes 10 years, medication treatment 7 years, often feels that four limbs are sent out cool, numb, steps on cotton sense, lower limbs edema, itch, shouting pain on foot. Coordinate external application bubble course for the treatment of of pin when continuing medicine for oral administration, symptom is obviously improved, and continues a course for the treatment of of external application, and clinical symptom completely dissolve, does not recur again.

Claims

1. treat the Chinese medicine composition of diabetic foot for one kind, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight part: red sage root 15-25 part, Semen Persicae (parched) 7-17 part, Ligusticum wallichii 7-17 part, Radix Astragali 40-60 part, Radix Codonopsis 10-20 part, Rhizoma Atractylodis Macrocephalae (parched) 15-25 part, Spine of Chinese Honeylocust 20-28 part, Stem of Sargentgloryvine 20-28 part, radix scrophulariae 10-20 part, Radix Rehmanniae 15-25 part, root of herbaceous peony 10-20 part, leech 5-15 part, Rhizoma Atractylodis (parched) 10-20 part, radix paeoniae rubrathe 10-20 part, Rhizome of Glabrous Greenbrier 15-25 part, Radix Glycyrrhizae 5-13 part.

2. the Chinese medicine composition for the treatment of diabetic foot according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the medicine of following weight part: the red sage root 20 parts, Semen Persicae (parched) 12 parts, Ligusticum wallichii 12 parts, the Radix Astragali 50 parts, Radix Codonopsis 15 parts, Rhizoma Atractylodis Macrocephalae (parched) 20 parts, Spine of Chinese Honeylocust 24 parts, Stem of Sargentgloryvine 24 parts, radix scrophulariae 15 parts, Radix Rehmanniae 20 parts, the root of herbaceous peony 15 parts, leech 10 parts, Rhizoma Atractylodis (parched) 15 parts, the radix paeoniae rubrathe 15 parts, Rhizome of Glabrous Greenbrier 20 parts, Radix Glycyrrhizae 9 parts.