CN103830562A - Medicament composition for treating freckle and preparation method thereof - Google Patents

Abstract

The invention discloses a medicament composition for treating freckle and a preparation method of the medicament composition. The medicament composition is mainly prepared into an internal-use medicine from medicines such as radix polygonati officinalis, cimicifuga foetida, radix angelicae, saposhnikovia divaricata, the root of kudzu vine, astragalus membranaceus, ginseng, rhizoma atractylodis, ligusticum and angelica sinensis according to a certain weight ratio, and the medicament composition is further prepared into an external-use ointment from medicines such as rhizoma bletillae, holy basil, resurrection lily rhizome, leonurus and the seed of Chinese dodder. The medicament composition disclosed by the invention has the functions of nourishing yin, tonifying liver, removing toxicity, generating muscles, dispelling damp and detoxifying, and can take effect quickly, good in curative effect and free of side effect when being used for treating freckle.

Description

A kind of pharmaceutical composition for the treatment of freckle and preparation method thereof

Technical field

The present invention relates to a kind of pharmaceutical composition for the treatment of freckle and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Freckle is the yellowish-brown point-like pigmentation spots occurring on skin of face, is chromosome dominant inheritance.Skin lesion can be brought out and increase the weight of to Exposure to Sunlight.Because current Western medicine cannot effectively be treated freckle, there is great demand to the Chinese medicine of rapid, effective treatment freckle in people therefore, up to now, also do not find about relevant report of the present invention.

Summary of the invention

The inventor, according to the research of theory of Chinese medical science and the checking repeatedly of clinical trial, has finally found the medicine of effective treatment freckle, thereby has completed the present invention.

Object of the present invention is just to provide a kind of Chinese medicine composition of more effective treatment freckle.

Another object of the present invention has just been to provide the preparation method of this Chinese medicine composition.

Medicine of the present invention is to select endo-medicine Rhizoma Polygonati Odorati, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Puerariae, the Radix Astragali, Radix Ginseng, Rhizoma Atractylodis, Rhizoma Ligustici, Radix Angelicae Sinensis, Flos Carthami, Radix Rhodiolae, Fructus Lycii, Semen Euryales, Fructus Citri Limoniae juice, vitamin E; External used medicine Pseudobulbus Bletillae (Rhizoma Bletillae), Herba Lysimachiae foenum-graeci, Rhizoma Kaempferiae, Herba Leonuri, Semen Cuscutae, Flos Hierochloes adoratae, Radix Asparagi, Mel, fresh tomato juice medicine combine preparation, make each efficacy of drugs produce synergism these drug regimens, thereby can effectively treat freckle.Wherein endo-medicine selects Rhizoma Polygonati Odorati to be because its nature and flavor are sweet, flat, enters lung, and stomach warp, has yin nourishing, moisturize, and relieving restlessness, the function of quenching the thirst, controls calentura sun wound, cough, excessive thirst, deficient fever, rapid digestion of food is easily hungry, frequent micturition.Select Rhizoma Cimicifugae to be because the sweet pungent micro-hardship of its nature and flavor is cool, enter lung, spleen, stomach warp, have yang invigorating, deliver rash, the function of removing toxic substances, controls seasonal epidemic pathogens epidemic disease labor, headache cold and heat, and laryngalgia, aphtha scar, macule is not saturating, sinking of QI of middle-JIAO, chronic diarrhea chronic dysentery, proctoptosis, women's metrorrhagia and leukorrhagia, uterus tenesmus, carbuncle sore tumefacting virus.Select the Radix Angelicae Dahuricae to be because its nature and flavor are pungent, temperature, enters lung, spleen, stomach warp, dispel the wind, and dampness, detumescence, the function of pain relieving, controls headache, supraorbital bone pain, toothache, nasal sinusitis, cold-damp stomachache, hemorrhoidal hamorrhage anal fistula, leucorrhea with red and white discharge, ulcer sores, skin pruritus due to dryness, scabies.Selecting Radix Saposhnikoviae is that temperature, enters bladder, lung, spleen channel, delivers because of its property acrid-sweet flavor, dispels the wind, and victory is wet, and the function of pain relieving, controls affection of exogenous wind-cold, and headache is dizzy, stiffness of the nape, and anemofrigid-damp arthralgia, joint is ached, and extremity contraction is anxious, tetanus.Select Radix Puerariae to be because its nature and flavor are sweet pungent, flat, enter spleen, stomach warp, there is yang invigorating expelling pathogenic factors from muscles, rash antidiarrheal, the function that relieving restlessness is only drunk, cures the wound cold, cures the wound cold, warm headache stiffness of the nape, dysphoria with smothery sensation is quenched one's thirst, has loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deafness.Select the Radix Astragali to be because its nature and flavor are sweet, tepor, enters lung, spleen channel, raw with the useful consolidating superficial resistance of defending, inducing diuresis to remove edema, and poison holding, the function of granulation promoting, controls spontaneous perspiration, night sweat, arthralgia due to stagnation of blood, edema, carbuncle is not burst or is burst and hold back for a long time; Process by the function that has invigorating middle warmer benefit, control internal injury overstrain, diarrhea due to hypofunction of the spleen, proctoptosis, deficiency of vital energy blood prostration, the disease of metrorrhagia and leukorrhagia and all weakness of QI blood deficiency.Select Radix Ginseng to be because its nature and flavor are sweet micro-sweet, temperature, enters spleen, lung meridian, has strongly invigorating primordial QI, Gu promote the production of body fluid de-, the function of calming the nerves, controls impairment caused by overstrain deficient, lack of appetite, asthenia, food is told in regurgitation, stool lingering diarrhea, empty cough with asthma is short, spontaneous perspiration sudden collapse, palpitation with fear, forgetful, dizziness and headache, sexual impotence, frequent micturition, quenches one's thirst, woman uterine bleeding, children's's intermittent infantile convulsion and prolonged deficiency are not multiple, the disease of all qi-blood-body fluid deficiencies.Select Rhizoma Atractylodis to be because its nature and flavor are arduous, temperature, enters spleen, stomach warp, has spleen invigorating, dampness, and resolving depression, wards off dirty function, control the wet tired spleen of containing, asthenia drowsiness, gastral cavity painful abdominal mass abdominal distention, inappetence, vomiting, has loose bowels, dysentery, malaria, phlegm retention, edema, seasonal epidemic pathogens flu, anemofrigid-damp arthralgia, flaccidity of the lower limbs, nyctalopia.Select Rhizoma Ligustici to be because its nature and flavor are pungent, temperature, returns urinary bladder channel, has cold expelling to dispel the wind, the function of removing damp and stopping pain, and for anemofrigid cold, top, mountain peak pain.Select Radix Angelicae Sinensis to be because its nature and flavor sweet, acrid, warm enters the heart, liver, spleen channel, have benefiting blood and regulating blood circulation, menstruction regulating and pain relieving, the function of moisturizing laxation, control menoxenia, amenorrhea stomachache ， mass in the abdomen knot is poly-, metrorrhagia, and headache due to deficiency of blood, dizzy, flaccidity syndrome and arthralgia syndrome, dryness of the intestine difficulty just, heavy after bloody dysentery, ulcer sores, incised wound, injury from falling down.Select Flos Carthami to be because its nature and flavor are pungent, temperature, enters the heart, Liver Channel, has promoting blood circulation to restore menstrual flow, and the function of blood stasis removing pain relieving is controlled amenorrhea ， mass in the abdomen, difficult labour, and stillborn fetus, disease that postpartum lochia can't go, blood stasis is had a pain, carbuncle, injury from falling down.Select Radix Rhodiolae to be because it is cold in nature, bitter and puckery flavor, has the function of promoting blood circulation and hemostasis, controls hemoptysis, spitting of blood, pneumonia cough, women leucorrhea.Select Fructus Lycii to be because its nature and flavor are sweet, flat, there is nourishing kidney, lung moistening, tonifying liver, the function of improving eyesight, controls hepatic and renal YIN deficiency, and soreness of the waist and knees is had a dizzy spell, the many tear of blurred vision, cough due to consumptive disease, quenches one's thirst, and loses clear.Select Semen Euryales to be because its property sweet-puckery flavor is flat, enter spleen, kidney channel, have reinforcing the kindey to control nocturnal emission, spleen reinforcing stopping leak, controls seminal emission, stranguria with turbid discharge, leukorrhagia, incontinence of urine, loose stool and diarrhea.Select Fructus Citri Limoniae juice to be because Fructus Citri Limoniae juice contains saccharide, vitamin c, vitamin B1, B2, the nutritional labelings such as nicotinic acid, calcium, phosphorus, ferrum, have cough-relieving, effects such as spleen invigorating of reducing phlegm, promote the production of body fluid, can enhancing immunity, slow down aging, Fructus Citri Limoniae is rich in vitamin C, also contains potassium and folic acid.In every 100 grams of Fructus Citri Limoniaes, moisture accounts for 89%, containing 1 gram, protein, 0.3 gram, fat, 2.1 grams of 6.9 grams of carbohydrates and fibers, can provide the heat of 121.4 kilojoules; Fructus Citri Limoniae contains nicotinic acid and abundant organic acid, and its taste is acid extremely, has very strong bactericidal action; Fructus Citri Limoniae can also promote the secretion of protease in stomach, increases gastrointestinal peristalsis, helps food digestion; In Fructus Citri Limoniae juice, contain a large amount of citrates, can suppress calcium salt crystallization, thereby stop renal calculus to form, the calculus even having become also can be dissolved be fallen, so edible Fructus Citri Limoniae can prevent and treat renal calculus, makes part chronic renal calculus patient's calculus reduce, diminish; Eat all right prevention and cure of cardiovascular disease of Fructus Citri Limoniae, can alleviate the effect that calcium ion impels blood coagulation, can prevent and treat hypertension and myocardial infarction, citric acid has contraction, increases solid blood capillary, reduce permeability, improve the effect of coagulation function and platelet counts, can shorten clotting time and bleeding time 31%～71%, there is anastalsis; Lemon vitamin content is very abundant, is the natural good merchantable brand of beauty treatment, can prevent and eliminate cutaneous pigmentation, promotes skin whitening effect; Fructus Citri Limoniae is eaten raw also has good antiabortive preventing or arresting vomiting effect, and therefore Fructus Citri Limoniae is the fruit that is applicable to women.Selecting vitamin e, is because vitamin e(Vitamin E) be a kind of fatsoluble vitamin, be one of topmost antioxidant.It can promote sex hormones secretion, thereby protects in addition T lymphocyte, protection erythrocyte, free radical resisting oxidation, anticoagulant to reduce the danger of myocardial infarction and cerebral infarction.Also there is to good curative effect the aspects such as burn, cold injury, capillary hemorrhage, climacteric syndrome, beauty treatment.

External used medicine selects Pseudobulbus Bletillae (Rhizoma Bletillae) to be because its property bitter but sweet flavor is cool, enters lung meridian, has tonifying the lung, hemostasis, and detumescence, raw sight, the function of sore, controls lung and hinders hemoptysis, epistaxis, incised wound is hemorrhage, swollen ulcer drug, ulcer pain, soup fire is burnt, rhagadia manus et pedis.Selecting Herba Lysimachiae foenum-graeci is that temperature, enters lung meridian, has cold-dispelling, wards off foul function because of its property acrid-sweet flavor, cold, the headache due to common cold that cures the wound, distension and fullness of the chest and abdomen, diarrhea, seminal emission, nasal obstruction, toothache.Select Rhizoma Kaempferiae to be because its nature and flavor are pungent, temperature, enters stomach warp, has warming middle-JIAO, helps digestion, and the function of pain relieving, controls trusted subordinate's cold type of pain, stops dyspepsia, traumatic injury, toothache.Select Herba Leonuri to be because its nature and flavor are arduous, cool, enter pericardium, Liver Channel, invigorate blood circulation, blood stasis dispelling, regulating menstruation, the function of the water that disappears, controls menoxenia, controls Lou difficult labour, retention of placenta, puerperal blood faints, abdominal pain due to blood stasis, metrorrhagia and metrostaxis, hematuria, rushes down blood, carbuncle skin infection.Select Semen Cuscutae to be because its property acrid-sweet flavor is flat, enter liver, kidney channel, have invigorating the liver and kidney, beneficial marrow, the function of improving eyesight, controls soreness of waist and knee joint, and seminal emission, quenches one's thirst, dripping urination, order is dark.Selecting Flos Hierochloes adoratae is because of its nature and flavor hardship, temperature,, nontoxic, enter bright, the Taiyin channels of foot sun, main attacked by pestiferous factors, stomach warming, preventing or arresting vomiting is told, and treats trusted subordinate's cold type of pain.Select Radix Asparagi to be because its nature and flavor sweetness and bitterness is cold, enter lung, kidney channel, have YIN nourishing, moisturize, lung heat clearing, the function of pathogenic fire reducing, controls fever due to yin deficiency, and cough is spitted blood, consumptive lung disease, lung abscess, laryngopharynx swelling and pain, quenches one's thirst, constipation.Select Mel to be because its nature and flavor are sweet, flat, enter lung, spleen, large intestine channel, there is invigorating middle warmer, moisturize, pain relieving, the function of removing toxic substances, controls xeropulmonary cough, dryness of the intestine constipation, gastralgia, nasal sinusitis, aphtha, the burning hot wound of soup, separates Aconitum Carmichaeli.Select fresh tomato juice to be because there is good effect in Tomato juice to preventing and treating freckle, in Fructus Lycopersici esculenti, containing abundant vitamin C, be described as " ascorbic warehouse ", vitamin C can suppress the activity of tryrosinase in skin, effectively reduce melanic formation, thereby make skin delicate, black speck disappears.

The specific embodiment

The consumption of composition of medicine of the present invention is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good curative effect within the scope of following dosage.

Endo-medicine:

4-10 gram of Radix Angelicae Dahuricae 5-15 gram of Rhizoma Polygonati Odorati 25-35 gram liter fiber crops

Radix Saposhnikoviae 4-10 gram of Radix Puerariae 8-16 gram of Radix Astragali 8-16 gram

Radix Ginseng 2-8 gram of Rhizoma Atractylodis 2-6 gram of Rhizoma Ligustici 4-10 gram

Radix Angelicae Sinensis 4-12 gram of Flos Carthami 5-15 gram of Radix Rhodiolae 3-9 gram

Fructus Lycii 6-15 gram of Semen Euryales 5-15 gram of Fructus Citri Limoniae juice 5-12 milliliter

Vitamin e 70-90 milligram.

External used medicine:

Pseudobulbus Bletillae (Rhizoma Bletillae) 8-18 gram of Herba Lysimachiae foenum-graeci 8-16 Keshan a kind of apple 5-10 gram

Herba Leonuri 6-12 gram of Semen Cuscutae 4-10 gram of Flos Hierochloes adoratae 2-8 gram

Radix Asparagi 4-10 gram of Mel 45-55 milliliter fresh tomato juice 10-20 milliliter.

Be preferably:

Endo-medicine:

10 grams of 5 grams of Radixs Angelicae Dahuricae of Rhizoma Polygonati Odorati 30 gram liter fiber crops

10 grams of 10 grams of Radixs Astragali of 5 grams of Radix Puerariaes of Radix Saposhnikoviae

5 grams of 3 grams of Rhizoma Ligusticis of 3 grams of Rhizoma Atractylodis of Radix Ginseng

5 grams of 10 grams of Radix Rhodiolaes of 5 grams of Flos Carthamis of Radix Angelicae Sinensis

10 milliliters of 10 grams of Fructus Citri Limoniae juice of 10 grams of Semen Euryaless of Fructus Lycii

80 milligrams of vitamin e.

External used medicine:

6 grams of 10 grams of Herba Lysimachiae foenum-graeci of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 Keshan a kind of apples

3 grams of 5 grams of Flos Hierochloes adorataes of 10 grams of Semen Cuscutae of Herba Leonuri

15 milliliters, 50 milliliters of fresh tomato juice of 5 grams of Mel of Radix Asparagi.

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

Endo-medicine:

1, Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

2, Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

3, the Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

4, Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

5, Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dries in time;

6, the Radix Astragali: choose clean impurity, remove residual root head and hollow larger root, be soaked in water;

7, Radix Ginseng: except removing LU, cutting;

8, Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;

9, Rhizoma Ligustici: get crude drug, remove impurity, big or small stepping, wash quickly is clean, runs through, and section, dries;

10, Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air, and section is dried;

11, Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

12, Radix Rhodiolae: the 7-9 month gathers, dry;

13, Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

14, Semen Euryales: first rise frying in wheat bran heat release pot to cigarette, cleaner Semen Euryales is poured into, stir to micro-yellow, take out, well sifted wheat bran, cools;

15, Fructus Citri Limoniae juice: extract according to quantity;

16, vitamin e: extract according to quantity.

External used medicine:

1, Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, dry in the air even to humidity, section, dry;

2, Herba Lysimachiae foenum-graeci: remove neck leaf, clean, dry;

3, Rhizoma Kaempferiae: choose decontamination, sieve dedust bits;

4, Herba Leonuri: choose decontamination, clean, run through, cutting, dries;

5, Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;

6, Flos Hierochloes adoratae: gather summer, chooses clean impurity, dries;

7, Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;

8, Mel: get pure Mel, temper with slow fire, filter skimming;

9, fresh tomato juice: extract according to quantity.

Two, preparation

The preparation of oral medicine:

1, the 4 times of amounts that first Radix Rhodiolae of described weight added water, soak 3-4 hour, then decoct 40 minutes with little fire, again the Rhizoma Polygonati Odorati of described weight, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Puerariae, the Radix Astragali, Radix Ginseng, Rhizoma Atractylodis, Rhizoma Ligustici, Radix Angelicae Sinensis, Flos Carthami, Fructus Lycii, Semen Euryales are decocted with water twice jointly, 6 times of amounts for the first time add water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filters to obtain decoction liquor for the first time.

2, the medicinal residues after filtering are for the first time added water 4 times and measured, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time.

3, merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, then adds Fructus Citri Limoniae juice, the vitamin e mixing and stirring of described weight and get final product, and medicinal liquid is divided into two doses and takes.

The preparation of external-applied ointment:

1, the Pseudobulbus Bletillae (Rhizoma Bletillae) of described weight, Herba Lysimachiae foenum-graeci, Rhizoma Kaempferiae, Herba Leonuri, Semen Cuscutae, Flos Hierochloes adoratae, Radix Asparagi are ground to the powder altogether.

2, mix and obtain above-mentioned grind to the powder and fresh tomato juice and the Mel mediation of described weight thoroughly external-applied ointment.

Medicine of the present invention has the function of YIN nourishing, tonifying liver, poison holding, granulation promoting, dehumidifying, removing toxic substances, is used for the treatment of freckle instant effect, good effect, has no side effect.

Further set forth below the beneficial effect of medicine of the present invention by test example, these tests comprise animal toxicity test and the clinical observation on the therapeutic effect test of medicine of the present invention.

The animal toxicity test of [test example 1] medicine of the present invention

Endo-medicine:

Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, divides two groups, and 15 every group, wherein one group is overdose test group, and another group is normal amount test group.Overdose test group is 25ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, and every day, secondary, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit activities, diet are normal, and medicine is without bad toxic and side effects.

External-applied ointment:

Get 30 of West Germany rabbits, male and female dual-purpose, body weight 2.0-2.5kg, first exposes skin by rabbit abdominal part hair removing, then the ointment mixing up is spread upon to rabbit abdominal part baring skin place, then twine and tie up with gauze, every day coating 2 times, continuously coating 5 days, observes administration reaction every day, result shows that rabbit activity, diet and skin are normal, and medicine is without bad toxic and side effects.

The clinical observation on the therapeutic effect of [test example 2] medicine of the present invention

1, physical data

Accept out-patient's totally 100 examples for medical treatment.

2, diagnostic criteria

How about 3～5 years old, occurring skin lesion, women is more.Freckle number increases gradually with age growth.Be apt to occur in face, particularly nose and two cheeks, can involve the exposure portion such as neck, shoulder, the back of the hand, and non-exposure portion is without erythra.Infringement is the shallow brown or big or small large macule of Semen phaseoli radiati that arrives of crineous syringe needle, circular, oval or irregularly shaped.Be dispersed in or the distribution of trooping, isolate and do not merge.No conscious sympton.Summer, erythra color burn, number increased after Exposure to Sunlight, and alleviate or disappear winter.Often there is family history.

3, Therapeutic Method

Take orally and the common medication of external-applied ointment:

Endo-medicine: select above-mentioned oral medicine, take to patient, every day 2 times, each 1 dose, boiled water is taken after mixing it with water, and 20 days is a course for the treatment of, takes continuously 2 courses for the treatment of.

External-applied ointment: selecting above-mentioned external-applied ointment, be applied to affected part, every day 3 times, 20 days is a course for the treatment of, continuously 2 courses for the treatment of of coating.

4, efficacy assessment standard

Effective: the recovery from illness of freckle symptom, recovers normal;

Take a turn for the better: freckle symptom alleviates, progressively take a turn for the better;

Invalid: not reach improvement standard person.

5, therapeutic outcome (seeing the following form):

In above-mentioned treatment, by Drug therapy freckle patient of the present invention 100 examples, effective 71 examples of result, obvious effective rate is 71%, 21 examples that take a turn for the better, and improvement rate is 21%, invalid 8 examples, total effective rate is 92%.

Claims (4)

1. a pharmaceutical composition for the treatment of freckle, is characterized in that: it is to be made up of the crude drug in following weight range:

Endo-medicine:

4-10 gram of Radix Angelicae Dahuricae 5-15 gram of Rhizoma Polygonati Odorati 25-35 gram liter fiber crops

Radix Saposhnikoviae 4-10 gram of Radix Puerariae 8-16 gram of Radix Astragali 8-16 gram

Radix Ginseng 2-8 gram of Rhizoma Atractylodis 2-6 gram of Rhizoma Ligustici 4-10 gram

Radix Angelicae Sinensis 4-12 gram of Flos Carthami 5-15 gram of Radix Rhodiolae 3-9 gram

Fructus Lycii 6-15 gram of Semen Euryales 5-15 gram of Fructus Citri Limoniae juice 5-12 milliliter

Vitamin e 70-90 milligram;

External used medicine:

Pseudobulbus Bletillae (Rhizoma Bletillae) 8-18 gram of Herba Lysimachiae foenum-graeci 8-16 Keshan a kind of apple 5-10 gram

Herba Leonuri 6-12 gram of Semen Cuscutae 4-10 gram of Flos Hierochloes adoratae 2-8 gram

Radix Asparagi 4-10 gram of Mel 45-55 milliliter fresh tomato juice 10-20 milliliter.

2. pharmaceutical composition according to claim 1, wherein the consumption of each crude drug is:

Endo-medicine:

10 grams of 5 grams of Radixs Angelicae Dahuricae of Rhizoma Polygonati Odorati 30 gram liter fiber crops

10 grams of 10 grams of Radixs Astragali of 5 grams of Radix Puerariaes of Radix Saposhnikoviae

5 grams of 3 grams of Rhizoma Ligusticis of 3 grams of Rhizoma Atractylodis of Radix Ginseng

5 grams of 10 grams of Radix Rhodiolaes of 5 grams of Flos Carthamis of Radix Angelicae Sinensis

10 milliliters of 10 grams of Fructus Citri Limoniae juice of 10 grams of Semen Euryaless of Fructus Lycii

80 milligrams of vitamin e;

External used medicine:

6 grams of 10 grams of Herba Lysimachiae foenum-graeci of Pseudobulbus Bletillae (Rhizoma Bletillae), 10 Keshan a kind of apples

3 grams of 5 grams of Flos Hierochloes adorataes of 10 grams of Semen Cuscutae of Herba Leonuri

15 milliliters, 50 milliliters of fresh tomato juice of 5 grams of Mel of Radix Asparagi.

3. according to the preparation method of pharmaceutical composition described in claim 1 or 2, it is characterized in that: it comprises the following steps:

(1) get the raw materials ready

Endo-medicine:

(1) Rhizoma Polygonati Odorati: remove impurity, clean earth, moistening is even to inside and outside humidity, and section, dries;

(2) Rhizoma Cimicifugae: choose decontamination, slightly foam washing is clean, pulls out, runs through, and section, dries;

(3) Radix Angelicae Dahuricae: choose clean impurity, wash, soak, pull out and run through, slightly shine to crust during without soapy feeling, then after moistening, chip drying;

(4) Radix Saposhnikoviae: remove residual stem, be soaked in water, pull out, run through section, dry;

(5) Radix Puerariae: choose decontamination, clean, be soaked in water, pull out, run through, section, dries in time;

(6) Radix Astragali: choose clean impurity, remove residual root head and hollow larger root, be soaked in water;

(7) Radix Ginseng: except removing LU, cutting;

(8) Rhizoma Atractylodis: choose decontamination, with blister to seven, most probably saturating, pull out, run through rear section, dry;

(9) Rhizoma Ligustici: get crude drug, remove impurity, big or small stepping, wash quickly is clean, runs through, and section, dries;

(10) Radix Angelicae Sinensis: choose decontamination, clean, moistening, slightly dries in the air, and section is dried;

(11) Flos Carthami: choose clean impurity, remove stem and leaf, base of a fruit head, dry;

(12) Radix Rhodiolae: the 7-9 month gathers, dry;

(13) Fructus Lycii: the clean impurity of winnowing with a dustpan, pluck residual stalk and the base of a fruit;

(14) Semen Euryales: first rise frying in wheat bran heat release pot to cigarette, cleaner Semen Euryales is poured into, stir to micro-yellow, take out, well sifted wheat bran, cools;

(15) Fructus Citri Limoniae juice: extract according to quantity;

(16) vitamin e: extract according to quantity;

External used medicine:

(1) Pseudobulbus Bletillae (Rhizoma Bletillae): choose decontamination, be soaked in water, pull out, dry in the air even to humidity, section, dry;

(2) Herba Lysimachiae foenum-graeci: remove neck leaf, clean, dry;

(3) Rhizoma Kaempferiae: choose decontamination, sieve dedust bits;

(4) Herba Leonuri: choose decontamination, clean, run through, cutting, dries;

(5) Semen Cuscutae: cross square-bottomed bamboo basket and remove impurity, clean, dry;

(6) Flos Hierochloes adoratae: gather summer, chooses clean impurity, dries;

(7) Radix Asparagi: choose decontamination, water is cleaned, and moistening is even to inside and outside humidity, cutting, dry;

(8) Mel: get pure Mel, temper with slow fire, filter skimming;

(9) fresh tomato juice: extract according to quantity;

(2) preparation

The preparation of oral medicine:

(1) the 4 times of amounts that first Radix Rhodiolae of described weight added water, soak 3-4 hour, then decoct 40 minutes with little fire, again the Rhizoma Polygonati Odorati of described weight, Rhizoma Cimicifugae, the Radix Angelicae Dahuricae, Radix Saposhnikoviae, Radix Puerariae, the Radix Astragali, Radix Ginseng, Rhizoma Atractylodis, Rhizoma Ligustici, Radix Angelicae Sinensis, Flos Carthami, Fructus Lycii, Semen Euryales are decocted with water twice jointly, 6 times of amounts for the first time add water, intense fire decocts boiling 10 minutes, then uses slow fire boiling 25 minutes, filters to obtain decoction liquor for the first time;

(2) medicinal residues after filtering are for the first time added water 4 times and measured, intense fire decocts boiling, then uses slow fire boiling 20 minutes, filters to obtain decoction liquor for the second time;

(3) merge twice decoction liquor, intense fire boils, then uses slow fire boiling 10 minutes, then adds Fructus Citri Limoniae juice, the vitamin e mixing and stirring of described weight and get final product, and medicinal liquid is divided into two doses and takes;

The preparation of external-applied ointment:

(1) Pseudobulbus Bletillae (Rhizoma Bletillae) of described weight, Herba Lysimachiae foenum-graeci, Rhizoma Kaempferiae, Herba Leonuri, Semen Cuscutae, Flos Hierochloes adoratae, Radix Asparagi are ground to the powder altogether;

(2) mix and obtain above-mentioned grind to the powder and fresh tomato juice and the Mel mediation of described weight thoroughly external-applied ointment.

4. a using method for the treatment of the pharmaceutical composition of freckle, is characterized in that: the external method of the instructions of taking of described endo-medicine and external-applied ointment is as follows:

Endo-medicine: select above-mentioned oral medicine, take to patient, every day 2 times, each 1 dose, boiled water is taken after mixing it with water, and 20 days is a course for the treatment of, takes continuously 2 courses for the treatment of;

External-applied ointment: selecting above-mentioned external-applied ointment, be applied to affected part, every day 3 times, 20 days is a course for the treatment of, continuously 2 courses for the treatment of of coating.