CN101780258B - Non-sucrose type shenmei stomach nourishing granule and preparation method thereof - Google Patents
Non-sucrose type shenmei stomach nourishing granule and preparation method thereof Download PDFInfo
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- CN101780258B CN101780258B CN2010101247037A CN201010124703A CN101780258B CN 101780258 B CN101780258 B CN 101780258B CN 2010101247037 A CN2010101247037 A CN 2010101247037A CN 201010124703 A CN201010124703 A CN 201010124703A CN 101780258 B CN101780258 B CN 101780258B
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Abstract
The invention discloses a non-sucrose type shenmei stomach nourishing granule and a preparation method thereof. The non-sucrose type shenmei stomach nourishing granule comprises the components of dextrin, 55% of ethanol and clear paste powder prepared by radix glehniae, hawthorn, dark plum, safflower, curcuma zedoary, elecampane, dandelion, salvia, licorice root, white paeony root and angelica, wherein the weight ratio of the clear paste powder, the dextrin and the 55% ethanol is 1:1-3:0.1-0.3. The preparation method comprises the steps of weighing the clear paste powder and the dextrin according to the weight ratio, and then granulating by a groove-shaped mixing machine to obtain the non-sucrose type shenmei stomach nourishing granule. The invention has the advantage that the granule is suitable for diabetic patients and can improve the blending effect of the clear paste powder and the dextrin. The preparation method can increase the molding rate of the granule, thereby increasing product yield and reducing the consumption of the clear paste powder and the dextrin.
Description
Technical field
The present invention relates to a kind of medicine and preparation method thereof, is a kind of non-sucrose type shenmei stomach nourishing granule and preparation method thereof specifically.
Background technology
The character of non-sucrose type shenmei stomach nourishing granule is brown granule; Mildly bitter flavor; Function cures mainly: the yin nourishing stomach function regulating, and it is scorching hot to be used to have a stomachache, noisy like hungry, pharyngoxerosis, constipation with dry stool; Superficial gastritis, type of deficiency of stomach yin chronic gastritis and various stomach discomfort disease; Ingredient is Radix Glehniae, Fructus Crataegi, Fructus Mume, Flos Carthami, Rhizoma Curcumae, Radix Inulae, Herba Taraxaci, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Angelicae Sinensis; More than ten simply, except that Radix Inulae, ten flavors such as all the other Radix Glehniaes decoct with water secondary (Radix Inulae treats that the water back of boiling adds), each 3 hours, collecting decoction left standstill, and filtered, filtrate is concentrated into the clear paste that relative density is about 1.30 (90～95 ℃).Qinghuo reagent, dextrin and cane sugar powder then, mixing is made granule, and drying promptly gets non-sucrose type shenmei stomach nourishing granule.But existing shenmei stomach nourishing granule contains cane sugar powder, makes the diabetes patient to eat; And the preparation method yield of existing shenmei stomach nourishing granule is low, it is big to consume, and promptly the yield of shenmei stomach nourishing granule is up to 80%, produces 10000 bags of granules and consumes shenmei stomach nourishing granule clear paste powder 50kg, consumes dextrin 100kg.
Summary of the invention
Goal of the invention: the purpose of this invention is to provide a kind of non-sucrose type shenmei stomach nourishing granule that can enlarge the scope of application; Another object of the present invention provides a kind of preparation method that can improve yield, reduce the non-sucrose type shenmei stomach nourishing granule that consumes.
Technical scheme: in order to solve above-mentioned first purpose, the technical solution adopted in the present invention is: a kind of non-sucrose type shenmei stomach nourishing granule, its component comprises dextrin, 55% ethanol and the clear paste powder of being made by Radix Glehniae, Fructus Crataegi, Fructus Mume, Flos Carthami, Rhizoma Curcumae, Radix Inulae, Herba Taraxaci, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae, the Radix Paeoniae Alba, Radix Angelicae Sinensis, wherein clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 1～3: 0.1～0.3.
In order to solve above-mentioned second purpose, the technical solution adopted in the present invention is: a kind of preparation method of non-sucrose type shenmei stomach nourishing granule, this method comprises the steps:
1) takes by weighing clear paste powder and dextrin according to weight ratio;
2) grooved mixing granulation: the clear paste powder and the dextrin that claim to prepare are dropped in the trough type mixing machine, stirred 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65～75 ℃ of dryings 2～4 hours are taken out, and cool and promptly get described non-sucrose type shenmei stomach nourishing granule.
Beneficial effect: compared with prior art, non-sucrose type shenmei stomach nourishing granule is adjusted prescription among the present invention, can not only be suitable for the diabetes patient, and can improve clear paste powder and dextrin blend effect; Adopt the preparation method among the present invention, can improve the molding particles rate, thereby improve the consumption of product yield, reduction clear paste powder and dextrin.
The specific embodiment
Further set forth the present invention below by embodiment, should understand these embodiment and only be used to the present invention is described and be not used in and limit the scope of the invention.
Embodiment 1: a kind of non-sucrose type shenmei stomach nourishing granule of the present invention, and its component comprises dextrin, 55% ethanol and clear paste powder, wherein clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 1.32: 0.21,55% ethanol is meant that volumetric concentration is 55% ethanol.
The prescription of clear paste powder is among the present invention: Radix Glehniae 140g, Fructus Crataegi 117g, Fructus Mume 35g, Flos Carthami 105g, Rhizoma Curcumae 105g, Radix Inulae 70g, Herba Taraxaci 175g, Radix Salviae Miltiorrhizae 140g, Radix Glycyrrhizae 70g, Radix Paeoniae Alba 175g, Radix Angelicae Sinensis 117g.
Method for making:
The first step, preparation clear paste powder:
1) take by weighing by the prescription of above-mentioned clear paste powder and produce the ten required consumptions of clean medical material simply of 125 bags of (every bag of 5g) non-sucrose type shenmei stomach nourishing granules, standby;
2) decoct: above ten simply, and other Chinese crude drug feeds intake earlier except that Radix Inulae, and first fries in shallow oil every jar, and to add water be 8 times of medical material amount, adds Radix Inulae behind the ebuillition of heated, protects and boiled 3 hours, and filtration enters settling tank to extracting solution through 200 order filters.Second fries in shallow oil the water heating extraction that adds 4 times of medical material amounts, protects and boils 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: the extracting solution precipitation is 24～36 hours in the settling tank, extracts supernatant and is filtered in the triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrate: when supernatant is concentrated into relative density in triple effect evaporator is that 1.00～1.10 (35～40 ℃ of mensuration) are when above, rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters, concentrate and be mixed to relative density (90～95 ℃ of mensuration) and be at 1.30～1.32 o'clock and go out cream, to storing in the cream bucket, standby;
5) vacuum drying: vacuum :-0.1MPa wherein; Temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves, obtain the clear paste powder, the yield of clear paste powder is 21%.Immediately the clear paste powder is packaged with the double-layer plastic bag after the pulverizing, standby;
In second step, according to the clear paste powder: dextrin: 55% alcoholic acid weight ratio takes by weighing clear paste powder, dextrin and 55% ethanol;
The 3rd step, the non-sucrose type shenmei stomach nourishing granule clear paste powder and the dextrin that claim to prepare are dropped in the trough type mixing machine, stirred 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate 65～75 ℃ of dryings 2 hours with 12 order stainless steel sifts, take out, cool and promptly get described non-sucrose type shenmei stomach nourishing granule; The yield of non-sucrose type shenmei stomach nourishing granule is 92%, and produce 125 bags of granules and consume number: shenmei stomach nourishing granule clear paste powder consumes 269g, and dextrin consumes 356g.
Embodiment 2: substantially the same manner as Example 1, different is the clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 2.2: 0.3, and be 3 hours the drying time in method for making the 3rd goes on foot; The yield of non-sucrose type shenmei stomach nourishing granule is 91.6%, and produce 125 bags of granules and consume number: non-sucrose type shenmei stomach nourishing granule clear paste powder consumes 195g, and dextrin consumes 429g.
Embodiment 3: substantially the same manner as Example 1, different is the clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 2: 0.1.
Embodiment 4: substantially the same manner as Example 1, different is the clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 1: 0.1.
Embodiment 5: substantially the same manner as Example 1, different is the clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 3: 0.3.
Embodiment 6: substantially the same manner as Example 2, different is that baking temperature is 70～75 ℃ in method for making the 3rd goes on foot, and the time is 4 hours.
Embodiment 7: the non-sucrose type shenmei stomach nourishing granule study on the stability: get three batches of packaged non-sucrose type shenmei stomach nourishing granules, under medicine storage requirement, in 0,3,6,12,18,24,36,48 month pick test, operative norm YBZ02982008 investigates, the result: effect duration is 3 years, and the stability test time limit is after effect duration 1 year.
Embodiment 8: the clinical efficacy test
1, material and method
The non-sucrose type shenmei stomach nourishing granule of 1.1 sample: embodiment 1 preparation, specification: every bag of 5g
1.2 subjects: 30 of type 1 diabetes people, 50 of type 2 diabetes mellitus people, type 1 diabetes people and type 2 diabetes mellitus people's blood sugar concentration is conformance with standard;
1.3 amount: eating method is warm boiled water ante cibum, one time 1 bag, 3～4 times on the one, the test-meal cycle is 30 days;
2, detect blood sugar concentration (according to the diagnosis of diabetes standard detection)
3, conclusion
The experimenter took non-sucrose type shenmei stomach nourishing granule of the present invention 30 days continuously, experimenter's blood sugar concentration is up to standard with the equal energy in the back of taking medicine on an empty stomach, be that non-sucrose type shenmei stomach nourishing granule of the present invention can offer diabetes patient, and experimenter's blood sugar concentration also can be up to standard.
Claims (2)
1. non-sucrose type shenmei stomach nourishing granule, it is characterized in that, its component is made up of dextrin, 55% ethanol and clear paste powder, clear paste powder: dextrin: 55% alcoholic acid weight ratio is 1: 1～3: 0.1～0.3, wherein the prescription of clear paste powder is: Radix Glehniae 140g, Fructus Crataegi 117g, Fructus Mume 35g, Flos Carthami 105g, Rhizoma Curcumae 105g, Radix Inulae 70g, Herba Taraxaci 175g, Radix Salviae Miltiorrhizae 140g, Radix Glycyrrhizae 70g, Radix Paeoniae Alba 175g, Radix Angelicae Sinensis 117g, and the concrete preparation process of clear paste powder is as follows:
1) take by weighing ten consumptions of clean medical material simply by the prescription of above-mentioned clear paste powder, standby;
2) decoct: above ten simply, other Chinese crude drug feeds intake earlier except that Radix Inulae, first fries in shallow oil every jar, and to add water be 8 times of medical material amount, add Radix Inulae behind the ebuillition of heated, the guarantor was boiled 3 hours, and extracting solution filters through 200 order filters and enters settling tank, and second fries in shallow oil the water heating extraction that adds 4 times of medical material amounts, the guarantor was boiled 3 hours, and extracting solution filters through 200 order filters and enters settling tank;
3) precipitation: the extracting solution precipitation is 24～36 hours in the settling tank, extracts supernatant and is filtered in the triple effect evaporator through 200 order filters, and precipitate is by offal treatment;
4) concentrate: the relative density when supernatant is concentrated into 35～40 ℃ in triple effect evaporator is more than 1.00～1.10, rare clear paste is filtered in the suction vacuum decompressioning and concentrating tank through 200 order filters, concentrate and the relative density when being mixed to 90～95 ℃ is to go out cream at 1.30～1.32 o'clock, to storing in the cream bucket, standby;
5) vacuum drying: vacuum :-0.1MPa wherein; Temperature: 78～82 ℃, 20～24 hours drying times;
6) beat powder: smashing fineness 80 mesh sieves obtain the clear paste powder.
2. the preparation method of a kind of non-sucrose type shenmei stomach nourishing granule according to claim 1 is characterized in that, this method comprises the steps:
1) takes by weighing clear paste powder and dextrin according to weight ratio;
2) grooved mixing granulation: the clear paste powder and the dextrin that claim to prepare are dropped in the trough type mixing machine, stirred 20 minutes, slowly add 55% ethanol while stirring, to making soft material, granulate with 12 order stainless steel sifts, 65～75 ℃ of dryings 2～4 hours are taken out, and cool and promptly get described non-sucrose type shenmei stomach nourishing granule.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389465B (en) * | 2011-11-21 | 2013-07-17 | 四川豪运药业股份有限公司 | Traditional Chinese medicine composition for treating gastropathy and its preparation method |
| CN105056105A (en) * | 2015-07-22 | 2015-11-18 | 南京同仁堂药业有限责任公司 | Preparation method and application of Shenmei stomach-nourishing particle (containing ginseng and dark plum) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103356815B (en) * | 2013-07-09 | 2015-04-22 | 江苏中兴药业有限公司 | Forming method of granules for regulating qi and reducing phlegm |
| CN103859111A (en) * | 2014-03-18 | 2014-06-18 | 贵州省印江自治县梵净青茶业有限责任公司 | Stomach-nourishing tea for treating chronic gastritis |
| CN115590939A (en) * | 2022-07-28 | 2023-01-13 | 四川豪运药业股份有限公司（Cn） | Ginseng and plum stomach nourishing granule clear paste powder and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606962A (en) * | 2008-06-18 | 2009-12-23 | 肖军平 | Sugarless south isatis root granules and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1172702C (en) * | 2002-06-14 | 2004-10-27 | 云南植物药业有限公司 | Sugar-free erigeron breviscapus granule and its prepn and application |
-
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101606962A (en) * | 2008-06-18 | 2009-12-23 | 肖军平 | Sugarless south isatis root granules and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 宋娟娜等.清口颗粒无糖型颗粒剂成型工艺的研究.《第四军医大学学报》.2008,第29卷(第14期),第1334-1336页. * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102389465B (en) * | 2011-11-21 | 2013-07-17 | 四川豪运药业股份有限公司 | Traditional Chinese medicine composition for treating gastropathy and its preparation method |
| CN105056105A (en) * | 2015-07-22 | 2015-11-18 | 南京同仁堂药业有限责任公司 | Preparation method and application of Shenmei stomach-nourishing particle (containing ginseng and dark plum) |
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Denomination of invention: Non-sucrose type shenmei stomach nourishing granule and preparation method thereof Effective date of registration: 20130106 Granted publication date: 20111221 Pledgee: Zhenjiang Jiangsu rural commercial bank Limited by Share Ltd Zhongshan Road branch Pledgor: Jiangsu Zhongxing Pharmaceutical Co., Ltd. Registration number: 2012320000002 |
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Address after: 212009 Zhenjiang City, Jiangsu province high tech Industrial Park of Dantu District No. 86 Leng Yu Lu Patentee after: Jiangsu Zhongxing Pharmaceutical Co., Ltd. Address before: 212009 No. three, No. 6, weft Road, Zhenjiang hi tech Industrial Development Zone, Jiangsu, China Patentee before: Jiangsu Zhongxing Pharmaceutical Co., Ltd. |
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