CN1044974C - Anti- hepatitis B preparation - Google Patents
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- CN1044974C CN1044974C CN94107070A CN94107070A CN1044974C CN 1044974 C CN1044974 C CN 1044974C CN 94107070 A CN94107070 A CN 94107070A CN 94107070 A CN94107070 A CN 94107070A CN 1044974 C CN1044974 C CN 1044974C
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Abstract
The present invention relates to an anti-hepatitis B preparation which is prepared by using medically accepted ants with the functions of protecting the liver, resisting viruses, nourishing the liver and kidney, strengthening the spleen, benefiting qi, nourishing blood and regulating the immunity of human bodies as main medicines and using natural animal and plant medicines with the functions of protecting the liver, clearing heat, removing toxicity, strengthening the spleen, promoting diuresis, nourishing blood, promoting blood circulation, soothing the liver, regulating qi and nourishing the liver and kidney as auxiliary medicines by adopting a production technology which is different from a traditional production technology and is similar to a fermentation technology. The preparation of the present invention has the functions of strengthening body resistance, eliminating pathogenic factors, integrally strengthening the function of organisms, regulating the immunity of human bodies in two directions, and resisting and killing viruses. Thus, the preparation of the present invention not only can effectively eliminate hepatitis B viruses and heal hepatitis B, but also has obvious effect on treatment of hepatitis A, hepatitis C, hepatitis D and diseases, such as fatty liver, liver cirrhosis, liver cancer, rheumatoid disease, etc.
Description
The invention belongs to the formulated Chinese medicine medicine of natural animal-plant medical material, be specifically related to a kind of anti-hepatitis B Chinese medicine medicine.
Hepatitis B is the liver inflammatory damage that is caused by hepatitis B virus, is a kind of infectious disease that current popular is the most extensive, harm is the most serious.Owing to still there is not ideal Therapeutic Method to cure the patient so far, bring great misery and worry for patient and family thereof, cause very big harm to society.
At present clinical commonly used as anti-virus formulations such as interferon, polyinosini, vidarabines, they seldom can make the hepatitis virus complete obiteration, so can not cure; Adopt immune ribonucleic acid (iRNA), thymosin, transfer factor (TF), phytohaemagglutinin immunopotentiating agent raise immunity such as (PHA), get rid of viral infection, improve clinical symptoms, but it is how invalid that hepatitis B surface antigen (HBsAg) is turned out cloudy; Adopt liver-protecting medicines such as glucuronolatone, inosine, dissopropylamine ascorbate, conscience treasured, though can improve or regulate liver function to a certain extent, blindly abuse increases the weight of burden of liver on the contrary, is unfavorable for the recovery of hepatitis; The traditional Chinese medical science adopts the method for strengthening vital QI to eliminate pathogenic factors, wholistic therapy to obtain reasonable effect, and Chinese medicine decoction is very inconvenient because of taking though the doctor can be according to state of an illness determination of treatment based on pathogenesis obtained through differentiation of symptoms and signs, is difficult for adhering to.The ant-made drug for curing B-hepatitis of existing Chinese patent medicine such as JIANGANLING JIAONANG, ZHULINGDUOTANG ZHUSHEYE and Wu Zhicheng etc. because curative effect is slow, the course of treatment is long, patient lacks perseverance, are often given up halfway mostly.
The object of the present invention is to provide a kind of natural Chinese medicine anti-hbv drug that can effectively prevent and treat hepatitis B.
The present invention is according to theory of Chinese medical science, select for use by what medical circle was generally acknowledged at the hepatitis B pathogenesis and to have a hepatoprotective antiviral, nourishing the liver and kidney, spleen invigorating, benefiting QI and nourishing blood, mediator's body immunity function, contain a large amount of vitamin again, trace element, the Formica fusca of the senior tonic of cursive script formaldehyde is a principal agent, cooperate hepatoprotective again, heat-clearing and toxic substances removing, the sharp alunite of spleen invigorating, nourshing blood and promoting blood circulation, depressed liver-energy dispersing and QI regulating, nourishing the liver and kidney, QI invigorating class Chinese medicine, employing is different from traditional new " like fermentation " production technology and produces anti-hbv drug, has strengthening vital QI to eliminate pathogenic factors, strengthen the human body function on the whole, the two-ways regulation body immunity, make the generated human antibody cell, thereby reach the purpose of eliminating hepatitis B virus and curing hepatitis B.
Anti-hbv drug of the present invention, its characteristics are to include at least the medicine of following compositing range (percetage by weight):
Formica fusca 40-60
Liver protecting medicine (A) 7-18
Antipyretic and antidotal type medicine (B) 5-15
Sharp alunite class medicine (C) 5-15 of spleen invigorating
The class of invigorating blood circulation medicine (D) 4-13
Nourishing the liver and kidney class medicine (E) 0-8
Depressed liver-energy dispersing and QI regulating class medicine (F) 0-5
QI invigorating class medicine (G) 0-5
Above-mentioned category-A medicine is meant at least a as in the liver protecting Chinese medicines such as Radix Sophorae Flavescentis, Cortex Moutan, Periostracum Cicadae, Spica Prunellae, Concha Ostreae, Fructus Chaenomelis, the Radix Paeoniae Alba, Bombyx Batryticatus, Semen Ziziphi Spinosae, Herba Glossogynes tenuifoliae; The category-B medicine is meant as Rhizoma Paridis, Herba Artemisiae Scopariae, Rhizoma Smilacis Glabrae, Radix Isatidis, Indigo Naturalis, Herba Sedi, loses at least a in the antipyretic and antidotal type Chinese medicines such as slurry grass, Radix Gentianae, Herba Taraxaci; C class medicine is meant at least a as in the sharp alunite class of spleen invigorating such as Rhizoma Atractylodis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Semen Coicis, Poria, the Seem Lablab Album Chinese medicine; D class medicine is meant at least a as in the class Chinese medicines of invigorating blood circulation such as Radix Salviae Miltiorrhizae, Rhizoma Polygoni Cuspidati, Radix Paeoniae Rubra, Fructus Crataegi, Rhizoma Corydalis, Radix Angelicae Sinensis, eupolyphaga, Radix Notoginseng; E class medicine is meant at least a as in the nourishing the liver and kidney class Chinese medicines such as Fructus Lycii, Fructus Ligustri Lucidi, Herba Epimedii, Cortex Acanthopancis, Cordyceps, Fructus Corni, Herba Taxilli, the Cortex Eucommiae, the Radix Rehmanniae, Radix Polygoni Multiflori; F class medicine is meant as at least a in the depressed liver-energy dispersing and QI regulating class Chinese medicines such as Radix Bupleuri, Rhizoma Cyperi, Radix Curcumae, Fructus Citri Sarcodactylis, fragrant lemon, Pericarpium Citri Reticulatae; G class medicine is meant at least a as in the QI invigorating class Chinese medicines such as Radix Codonopsis, Radix Glycyrrhizae, the Radix Astragali, Radix Ginseng, Rhizoma Polygonati, Fructus Jujubae.
The present invention is when prescription, select at least a in Formica fusca and hepatoprotective, heat-clearing and toxic substances removing, invigorating spleen to remove dampness, the class of the invigorating blood circulation Chinese medicine respectively for use by the principles of formulating prescriptions of monarch, except that Formica fusca, the preferably assembly of the similar medicine of multi-flavor of each class medicine, to bring into play the synergism of multiple medicine, obtain best curative effect.In order to improve the comprehensive therapeutic effect of anti-hepatitis B preparation, the present invention preferably adds at least a nourishing the liver and kidney and/or depressed liver-energy dispersing and QI regulating and/or QI invigorating class medicine respectively.
The present invention when prescription, select prescription composition, determine that each content range is no doubt important, in the content range of each composition, the best relative amount of determining its various kinds of drug is also very important, clinical trial and pharmacological research show, anti-hbv drug of the present invention, at following content range:
Formica fusca: A: B: C: D: E: F: G=100: 15-20: 13-18: 15-18: 12-16: 9-11: 5-7: 3-5 (weight) effect is better, recommends to select for use following two assembly sides in this scope:
Formica fusca 100 Radix Sophorae Flavescentis 3-5 Cortex Moutan 0.5-1.5 Concha Ostreae 2-4 Fructus Chaenomelis 3-5
Radix Paeoniae Alba 3-5 flea body 0.5-2 Herba Artemisiae Scopariae 3-5 Poria 2-4 Radix Salviae Miltiorrhizae 0.5-1.5
Rhizoma Polygoni Cuspidati 2-4 eupolyphaga 3-5 Rhizoma Dioscoreae 3-5 Semen Coicis 3-5 Poria 2-4
Radix Isatidis 1-3 Herba Taraxaci 2-4 Rhizoma Atractylodis Macrocephalae 4-6 Radix Notoginseng 3-5 Radix Polygoni Multiflori 3-5
Radix Rehmanniae 4-6 Fructus Lycii 5-7 Herba Epimedii 0.5-2 Radix Bupleuri 1-3 Radix Curcumae 0.5-2
Pericarpium Citri Reticulatae 0.5-1.5 Radix Astragali 2-4 Radix Ginseng 0.5-2 Rhizoma Polygonati 1-3 Fructus Schisandrae Chinensis 3-5
Ganoderma 3-5 Fructus Forsythiae 1-3 Radix Et Rhizoma Rhei 1-3
Formica fusca 100 Periostracum Cicadae 1-2.5 Spica Prunellae 2-4 Bombyx Batryticatus 2-4 Radix Paeoniae Alba 6-8
Indigo Naturalis 4-6 Herba Sedi 6-8 Herba Patriniae 3-5 Rhizoma Atractylodis 4-6 Fructus Amomi 3-5
Seem Lablab Album 6-8 Radix Paeoniae Rubra 5-7 Fructus Crataegi 3-5 Rhizoma Corydalis 1-2.5 Radix Angelicae Sinensis 3-5
Cortex Acanthopancis 5-7 Cordyceps 3-5 Radix Codonopsis 2-4 Radix Glycyrrhizae 0.5-1.5 0.5-1.5 Radix Ophiopogonis
Fructus Jujubae 1-2.5 Pericarpium Citri Reticulatae Viride 1-2.5 Radix Aucklandiae 1-2.5
In order to give full play to the drug effect of every herbal medicine in the anti-hbv drug of the present invention, the present invention has adopted the compound method that is different from Chinese medicine, characteristics mainly are various dissimilar classification of medicinal materials processing, and fine-powdered re-uses beans and Fructus Hordei Germinatus as " like the fermentation " production technology of drawing material, has fully extracted the active ingredient of the selected various natural animal-plant medical materials of the present invention, the effectiveness of medicine is given full play to, easily digest and assimilate, dose is little, and dosage form is various.Concrete processing method comprises:
1. will draw material Semen Glycines 2-4%, Semen sojae atricolor 0.5-2%, Fructus Hordei Germinatus 0.5-2% like the fermentation of fermentation technology, fermentation ground to form paste (promptly drawing material) with colloid mill after 24-36 hour in 20-40 degree container.
2. fresh animal kind medicines such as Formica fusca are added deionized water, grind to form paste with colloid mill.
3. viscosity and oil spice are put in the drying baker dry 12-24 hour at the 60-80 degree.
4. the other medicines beyond 2,3 were put in the inherent 25-35 degree of drying baker dry 12-24 hour, then its mixed powder are broken to the 70-80 order.
5. 3 spice is mixed mix homogeneously in 4 successively, be crushed to the 90-100 order together, below be referred to as full powder.
6. will draw material stick with paste be added to respectively that 2 animal kind medicines such as Formica fusca are stuck with paste and 5 full powder in, add deionized water respectively after, the former soaks down in room temperature and claimed animal to stick with paste in 12-24 hour, the latter soaks in the 28-40 degree and claimed full powder paste in 24-36 hour.
With above-mentioned 6 grindings after paste of the animal after the immersion and the mixing of full powder paste, add deionized water again, soaked 2-5 hour down in room temperature, agitation and filtration, room temperature soaked 1-2 hour down after filtering residue added deionized water again, decocted the one hour after-filtration that boils, and twice filtrate is mixed the back concentrating under reduced pressure and got concentrated solution, add the refined honey of 9-11% through fine filtering again, bottling, pressure sterilizing, packing are made oral liquid.
Above-mentioned 6 animals after soaking are stuck with paste and full powder stick with paste mix after again drying must mix spice.
1) powder: above-mentioned mixing spice is crushed to the 80-100 order, sieves, pack.The finished product radiation sterilization.
2) pill: above-mentioned mixing spice is crushed to the 100-120 order, and per 100 gram fine powders restrain with an amount of water pill, are drying to obtain with refined honey 50.The finished product radiation sterilization.
3) tablet: above-mentioned mixing spice is crushed to the 80-100 order, add accurate Rhizoma Dioscoreae fine powder as diluent, absorbent and disintegrating agent, and join a little lactose [or 7 parts of starch, 1 part in dextrin, 1 part of mixing of Icing Sugar] as diluent, with the distilled water is wetting agent, direct compression or sugar coating, the finished product radiation sterilization is carried out the total quality inspection by pharmacopeia, is used for after qualified clinical.
4) capsule (hard capsule)
Above-mentioned mixed material is crushed to the 100-120 order,, incapsulates the finished product radiation sterilization in 60-70 degree oven dry 2 hours.
Anti-hbv drug of the present invention, at the hepatitis B pathogenesis according to theory of Chinese medical science and clinical experience, the Formica fusca with hepatoprotective antiviral, nourishing the liver and kidney, spleen invigorating, benefiting QI and nourishing blood, mediator's body immunity function of selecting for use medical educational circles to generally acknowledge is a principal agent, be aided with hepatoprotective heat-clearing and toxic substances removing, invigorating spleen to remove dampness and nourshing blood and promoting blood circulation, depressed liver-energy dispersing and QI regulating again, nourishing the liver and kidney class natural animal-plant medicine is formulated, has strengthening vital QI to eliminate pathogenic factors, enhancing body function on the whole, the two-ways regulation immune function of human body produces the effect of antibody cell, thereby can eliminate hepatitis B virus effectively and cure hepatitis B.And because employing is different from traditional new " like fermentation " production technology, fully extracted the active ingredient of the selected various natural animal-plants of the present invention, the effectiveness of medicine is given full play to, therefore anti-hbv drug clinical prevention hepatitis B curative effect of the present invention is very remarkable, to other types hepatitis as: first, the third, fourth, fatty liver, liver cirrhosis, hepatocarcinoma, rheumatoid disease also have better curative effect.
Embodiment one
1. 2 kilograms of Semen Glyciness, 0.5 kilogram of Semen sojae atricolor, 0.5 kilogram of Fructus Hordei Germinatus are added 3.75 kilograms of deionized waters, place in the container,, grind to form paste with colloid mill, as drawing material 37 ± 1 ℃ of bottom fermentations 26 hours.
2. with the black how perverse Formica fusca of plan of 52 kilograms of work, 2 kilograms of eupolyphaga, add 5.4 kilograms of deionized waters, grind to form paste (ant paste) with colloid mill.
3. 1.5 kilograms of Radix Rehmanniae, 3 kilograms of Fructus Lycii, 1 kilogram of Rhizoma Polygonati, 2 kilograms of Fructus Schisandrae Chinensis are put into far-infrared ray drying oven in 60 ± 1 ℃ of dryings 24 hours.
4. with 2 kilograms of Radix Sophorae Flavescentiss, 0.5 kilogram Cortex Moutan, 1.5 kilogram Concha Ostreae, 2 kilograms of Fructus Chaenomeliss, 2 kilograms of Radix Paeoniae Albas, 0.5 kilogram Rhizoma Paridis, 2 kilograms of Herba Artemisiae Scopariaes, 1.5 kilogram Rhizoma Smilacis Glabrae, 0.5 kilogram Radix Salviae Miltiorrhizae, 1.5 kilogram Rhizoma Polygoni Cuspidati, 2 kilograms of Rhizoma Dioscoreaes, 2 kilograms of Semen Coiciss, 1.5 kilogram Poria, 2 kilograms of Radix Isatidiss, 1.5 kilogram Herba Taraxaci, 2.5 the kilogram Rhizoma Atractylodis Macrocephalae, 2 kilograms of Radix Notoginseng, 2 kilograms of Radix Polygoni Multiflori, 0.5 kilogram Herba Epimedii, 1 kilogram of Radix Bupleuri, 0.5 kilogram Radix Curcumae, 0.5 kilogram Pericarpium Citri Reticulatae, 1.5 the kilogram Radix Astragali, 0.5 kilogram Radix Ginseng, 2 kilograms of Ganodermas, 1 kilogram of Fructus Forsythiae, 1 kilogram of Radix Et Rhizoma Rhei is put into far-infrared ray drying oven in 30 ± 1 ℃ of dryings 24 hours, then it is mixed and pulverize, get fineness and be about 75 purpose mixed powders.
5. 3 spice is mixed successively in 4 the mixed powder, be crushed to together and obtain the full powder of about 95 purposes.
6. draw material respectively with 1 6.75 kilograms:
(1) add ant stick with paste in 3.65 kilograms, add 27 kilograms of deionized waters again and soaked 16 hours down in room temperature.
(2) add in the full powder 3.1 kilograms, add 115 kilograms of deionized waters again and under 37 ± 1 ℃ of temperature, seemingly fermented 26 hours.
With above-mentioned 6:(1), (2) spice after processing mixes the back and grinds, the deionized water that adds 309 kilograms again soaked 3 hours down in room temperature, stir after-filtration, the deionized water that filtering residue adds 1 times of the surplus quantity of slag again soaked 1.5 hours down in room temperature, the decoction 1 hour after-filtration that boils, twice filtrate is mixed back concentrating under reduced pressure (65 ℃), and fine filtering to get amount of liquid medicine be 270 kilograms, add 30 kilograms of the refined honeys of fine filtering again, after mixing, staticly settled 12 hours, fine filtering, bottling, pressure sterilizing, packing promptly gets anti-hepatitis B oral liquid I number.The case history summary:
1. Liu, man, 28 years old, people from Junan, Shandong suffered from the positives such as hepatitis B HBsAg, HBeAg in 1987, through taking anti-hepatitis B oral liquid I after numbers 15 days, transference cures such as the vexed pain in hepatic region, weak, poor sleep, check is turned out cloudy after 3 months, adheres to taking half a year, so far not recurrence more than 6 years.
2. Lee, woman, 36 years old, people from Mei County, Guangdong find hepatitis B 1,3,5 positives in February, 86, and obstinate is taken anti-hepatitis B oral liquid I number 3 first quarter moons in March, 90, to various transference cures of in August, 1993, check normal.
Embodiment two
With the crude drug of following content (kilogram), 2 kilograms of Semen Glyciness, 0.5 kilogram of Semen sojae atricolor, 0.5 kilogram of Fructus Hordei Germinatus be for drawing material, makes anti-hepatitis B oral liquid II number by the method for embodiment one:
Formica fusca 58 Periostracum Cicadaes 1 Spica Prunellae 1.5 Bombyx Batryticatus 1.5 Radix Paeoniae Albas 4
Indigo Naturalis 2.5 Herba Sedis 3.5 lose careless 2 Rhizoma Atractylodis, 2.5 Fructus Amomis 2 of slurry
Seem Lablab Album 3.5 Radix Paeoniae Rubra 3 Fructus Crataegis 2 Rhizoma Corydalis 1 Radix Angelicae Sinensis 2
0.5 Radix Ophiopogonis 0.5 of Cortex Acanthopancis 3 Cordyceps 2 Radix Codonopsis 1.5 Radix Glycyrrhizaes
Fructus Jujubae 1 Pericarpium Citri Reticulatae Viride 1 Radix Aucklandiae 1
Wherein: Formica fusca, Bombyx Batryticatus, Cordyceps are the animal class; Seem Lablab Album, Radix Ophiopogonis, Fructus Jujubae, close viscosity and oiliness spice when being classified as; The case history summary:
Clock, woman 42 years old, ShenZhen,GuangDong people from city, suffered from hepatitis B 1,3,5 positives in 1978, through Shanghai, various big hospital diagnosis and treatment such as Beijing, Guangdong, bad during fashion, begin to take anti-hepatitis B oral liquid II doing well,improving after number 1 month on February 15th, 92, adhere to taking half a year, to various transference cures of in October, 1993, through repeatedly check is all normal.
Embodiment three
With the crude drug of following content (kilogram), 2 kilograms of Semen Glyciness, 0.5 kilogram of Semen sojae atricolor, 0.5 kilogram of Fructus Hordei Germinatus be for drawing material, makes anti-hepatitis B oral liquid III number by the method for embodiment one:
Formica fusca 59 Radix Gentianaes 2 puncturevine caltrop fruits 3 testa mungos 4 Radix Et Rhizoma Rhei 3
Rhizoma Osmundae 2.5 Semen Astragali Complanatis 3 Radix Paeoniae Rubra 3 Herba Leonuris 2.5 Fructus Ligustri Lucidi 3
Cortex Fraxini 2.5 Semen Euryaless 3 Rhizoma Fagopyri Dibotryiss 2 Testa dolichoriss 3 Pollen Typhaes 2.5
Flos Carthami 2
Wherein: Formica fusca is the animal class;
The case history summary:
Zhang, woman 30 years old, Serpentis mouth hospital nurse, examine January 22 nineteen ninety, of a specified duration when suffering from hepatitis B, and through western medicines in treatment, curative effect does not show.Examine and see: right side of body dull pain, limbs fatigue, drowsiness lazyness is moving, and night, xerostomia played bitter taste morning; yellowish or reddish urine, constipation, following 1 centimetre of liver costal margin, touch a tender spot obviously liver power checking: turbid 14 units of zinc; surface antigen positive, body of the tongue is light red, the little purple in sharp limit, the weary Tianjin of few tongue, deep-thready pulse string.Take anti-hepatitis B oral liquid III of the present invention number, every day secondary, each 20 milliliters, after 3 months, illness is removed and is recovered, liver function is normal, the surface antigen sun is turned out cloudy.So far the stretched of surplusing in 3 years after recovering is strong.
Claims (2)
1. anti-hbv drug is characterized in that it is the medicament made from following materials based on weight and method:
Formica fusca 100 Periostracum Cicadae 1-2.5 Spica Prunellae 2-4 Bombyx Batryticatus 2-4 Radix Paeoniae Alba 6-8
Indigo Naturalis 4-6 Herba Sedi 6-8 loses the careless 3-5 Rhizoma Atractylodis 4-6 Fructus Amomi 3-5 of slurry
Seem Lablab Album 6-8 Radix Paeoniae Rubra 5-7 Fructus Crataegi 3-5 Rhizoma Corydalis 1-2.5 Radix Angelicae Sinensis 3-5
Cortex Acanthopancis 5-7 Cordyceps 3-5 Radix Codonopsis 2-4 Radix Glycyrrhizae 0.5-1.5 0.5-1.5 Radix Ophiopogonis
Fructus Jujubae 1-2.5 Pericarpium Citri Reticulatae Viride 1-2.5 Radix Aucklandiae 1-1.5,
Method is divided into following steps:
1) fermentation is drawn material Semen Glycines 2-4%, Semen sojae atricolor 0.5-2%, Fructus Hordei Germinatus 0.5-2%, fermentation ground to form paste with colloid mill after 24-36 hour in 20-40 degree container, must draw material and stick with paste;
2) fresh animal kind medicines such as Formica fusca are added deionized water, grind to form paste with colloid mill;
3) viscosity and oil spice are put in the drying baker dry 12-24 hour at the 60-80 degree;
4) with 2), 3) in addition other drug is put in the drying baker, dry 12-24 hour of 25-35 degree, then its mixed powder is broken to the 70-80 order;
5) with 3) spice mix in 4 successively) in mix homogeneously, be crushed to the 90-100 order together, full powder;
6) will draw material stick with paste be added to 2 respectively) animal kind medicines such as Formica fusca stick with paste and 5) full powder in, add deionized water respectively after, the former soaked 12-24 hour down in room temperature, the animal paste; The latter soaked 24-36 hour in the 28-40 degree, got full powder and stuck with paste;
7) with above-mentioned 6) the gained animal is stuck with paste and full powder is stuck with paste mixing, promptly.
2. according to the anti-hbv drug of claim 1, it is characterized in that it is mixed with regular dosage forms such as oral liquid, powder, tablet, pill or capsule with the conventional formulation method.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94107070A CN1044974C (en) | 1994-06-17 | 1994-06-17 | Anti- hepatitis B preparation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94107070A CN1044974C (en) | 1994-06-17 | 1994-06-17 | Anti- hepatitis B preparation |
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| Publication Number | Publication Date |
|---|---|
| CN1113779A CN1113779A (en) | 1995-12-27 |
| CN1044974C true CN1044974C (en) | 1999-09-08 |
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| CN94107070A Expired - Lifetime CN1044974C (en) | 1994-06-17 | 1994-06-17 | Anti- hepatitis B preparation |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101850046B (en) * | 2009-12-09 | 2011-07-27 | 北京绿源求证科技发展有限责任公司 | Chinese medicament for treating chronic hepatitis |
| CN102008645A (en) * | 2010-12-10 | 2011-04-13 | 冯学安 | Traditional Chinese medicine capsule for treating jaundice hepatitis |
| CN102327569A (en) * | 2011-10-08 | 2012-01-25 | 李莉 | Preparation method and application method of drug and herbal medicine thereof for curing chronic hepatitis B |
| CN102327569B (en) * | 2011-10-08 | 2012-12-05 | 李莉 | Preparation method and application method of drug and herbal medicine thereof for curing chronic hepatitis B |
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