CN104491574B - A kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B - Google Patents
A kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B Download PDFInfo
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Abstract
The invention provides a kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B, belong to Chinese medicine and healthcare field.The present invention carries out compatibility using peach kernel, Buddha's hand, Fructus Aurantii, the membrane of a chicken's gizzard, Semen Coicis, cordate houttuynia, dandelion, honeysuckle, purslane, cape jasmine, dark plum, radix glycyrrhizae, jujube as raw material, the effect of making each medicine, produces collaboration, promoting blood circulation and removing blood stasis, invigorating the spleen dehumidifying, righting nourishing the liver, clearing heat and detoxicating function are played altogether, to realize conditioning and therapeutic action to chronic hepatitis B.Clinical detection as shown by data, the Chinese medicine preparation of the medicine present invention of the present invention have clear and definite advantage in terms of sings and symptoms is improved, improve liver function, HBeAg (HBeAg) negative conversion rate, the anti-HBe frequence of seroconversion of HBeAg/, hepatitis B DNA (HBV DNA) negative conversion rate.
Description
Technical field
The present invention relates to a kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B, belong to Chinese medicine health-care field.
Technical background
Virus B hepatitis is a kind of worldwide disease, developing country's incidence of disease as caused by hepatitis type B virus
Height, for whole world Asymptomatic Carriers (HBsAg carrier) more than 2.8 hundred million, China accounts for more than 100,000,000 according to statistics.It is most asymptomatic, its
In 1/3 there is the clinical manifestation of hepatic lesion.Feature is that onset is relatively slow, non-icteric type more typical with Subclinical and chronic type
The easy chronicity of HBsAg lasting masculin persons.This disease is mainly propagated by blood and daily life close contact, and another way is mother and baby
Propagate.The application of hepatitis B vaccine is control and the essential measure for preventing hepatitis B.
Six big symptoms of virus B hepatitis：1st, the constitutional symptom of hepatitis B, which is mainly shown as, is short of physical strength, is tired, not having essence
God, mainly reduced with liver function damage, feed, food digestion malabsorption, caused by nutriment intake is reduced, the opposing party
Face, causing to consume because inflammation caused by hepatitis B increases and nutriment insufficiency of intake causes liver metabolism function to be damaged,
Plus the spiritual and psychological pressure of hepatitis B patient, the sleep and rest of hepatitis B patient are influenceed, causes hepatitis B patient to seem very
Without spirit.2nd, the symptom of digestive tract of hepatitis B patient is mainly shown as poor appetite, detests oil, nausea, abdominal distension, epigastric discomfort etc.
Symptom, it is primarily due to cause the secretion of bile to reduce during hepatitis so that the digestion and absorption of food are affected, in addition, stomach
The congestion and edema of enteron aisle can also influence the absorption and digestion of food.3rd, it is heavier to be primarily due to liver disease for the jaundice symptom of hepatitis B
When, the bilirubin concentration increase in blood, bilirubin is excluded from urine so that urine color burn, this is jaundice earliest period
Performance.4th, the pain symptom of hepatitis B is mainly shown as hepatalgia, the typically no pain symptom of hepatitis B patient, but works as Glisson's capsule
Anxiety, the pain nerve on Glisson's capsule is stimulated, just occurs upper right abdomen, and right season rib is uncomfortable or secret anguish.5th, hepatitis B patient can go out
The symptom of existing hepatosplenomegaly.Hepatitis early stage, spleen do not have obvious enlargement, and the later stage can be because the reason such as portal hypertension causes spleen
Dirty extravasated blood causes spleen enlargement.6th, showed outside the liver of hepatitis B, be mainly shown as liver cirrhosis patient dim complexion, hepatopathy face occur
Hold, there is also the symptoms such as spider angioma or liver palms and endocrinopathy.
Mainly detection five indexes of hepatitis b and the liver function index of clinical diagnosis hepatitis B.Five indexes of hepatitis b includes：Hepatitis B surface resists
Former HBsAg, hepatitis B surface antibody HBsAb, hepatitis B virus e antigen HBeAg, hepatitis B virus e antigen body HBeAb, the anti-core body HBcAb of hepatitis B e.
HBsAg, HBeAg, HBcAb are positive referred to as great three positive, and HBsAg, HBeAb, HBcAb are positive referred to as "small three positive".Great three positive
Connotation is the hepatitis B virus infection for having affirmative, and virus actively replicates, and viral load is more, and infectiousness is relatively strong.It is small by three
Sun is typically to be changed by " great three positive ", is that human body generates a certain degree of immunity for e antigens.It is it is generally acknowledged that small by three
The infectiousness of sun is smaller.The index of liver function is primarily referred to as glutamic-pyruvic transaminase（ALT）, glutamic-oxalacetic transaminease AST, total bilirubin
TBIL, bilirubin direct DBIL, indirect bilirubin IBIL five.Five liver function index significantly increases, then predicates B-mode disease
Virus hepatitis.
At present the treatment main a- interferon of medicine of chronic hepatitis B, Lamivudine, FCV, thymic peptide a1 and its
Its some antiviral drugs.These drug prices are high, and have certain side effect, and body can also be made while treatment
Into certain injury.
The content of the invention
It is an object of the invention to provide a kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B.
The present invention with peach kernel, Buddha's hand, Fructus Aurantii, the membrane of a chicken's gizzard, Semen Coicis, cordate houttuynia, dandelion, honeysuckle, purslane, cape jasmine,
Dark plum, radix glycyrrhizae, jujube are that raw material carries out compatibility, and the effect of making each medicine produces collaboration, play promoting blood circulation and removing blood stasis, invigorating the spleen dehumidifying altogether, help
Positive nourishing the liver, clearing heat and detoxicating function, to realize conditioning and therapeutic action to chronic hepatitis B.
According to long-term research, we think that chronic hepatitis B belongs to typical chronic disease, prolonged illness must hemostasis, hemostasis
Then disease of not dispelling is refractory.Peach kernel, bitter, sweet, flat；The thoughts of returning home, liver, large intestine channel；Function：Promoting blood circulation, relax bowel.Therefore the present invention
It is promoting blood circulation and removing blood stasis as dominating using peach kernel as monarch drug in a prescription, it specify that unique direction for treatment hepatitis B.
Buddha's hand, pungent, bitter, sour, temperature；Return liver, spleen, lung channel；Function：Liver-smoothing, qi-regulating, and stomach and alleviating pain.Fructus Aurantii, it is bitter, pungent, sour,
Temperature；Returns spleen, stomach；Function：Regulating the flow of QI to ease the stomach, the stagnant dissipate-swelling of row.The membrane of a chicken's gizzard, it is sweet, put down；Returns spleen, stomach, small intestine, bladder warp；Function：It is strong
Stomach helps digestion, arresting seminal emission.Semen Coicis, it is sweet it is light, be slightly cold；Enter spleen, stomach, lung, large intestine channel；Effect：Clearing heat and promoting diuresis, curing rheumatism, diuresis,
Beneficial lung apocenosis, strengthening the spleen and stomach, strengthening the bones and muscles.The present invention with Buddha's hand, Fructus Aurantii, the membrane of a chicken's gizzard, Semen Coicis altogether for adjutant, invigorating the spleen, dampness elimination, clearing damp.
Motherland's medical science thinks that damp evil can most love heresy, and damp evil is not removed then viral difficulty and gone out；Other adjutant, which focuses on, adjusts regulating the function of middle-JIAO taste, only because spleen
Stomach is the foundation of acquired constitution, and the unstrong then body of taste loses the source of rehabilitation.
Cordate houttuynia, acrid flavour are cold in nature；Enter liver, lung two pass through；Effect：It is clearing heat and detoxicating, inducing diuresis to remove edema.Dandelion, it is bitter, sweet, tremble with fear；
Return liver, stomach；Function：It is clearing heat and detoxicating, dispersing swelling and dissipating binds, inducing diuresis for treating strangurtia.Honeysuckle, it is sweet, tremble with fear；Return lung, the heart, stomach；Function：Heat-clearing
Removing toxic substances, wind-heat dissipating.Purslane, acid, tremble with fear；Enter liver, spleen two pass through；Function：Clearing heat and promoting diuresis, removing pattogenic heat from the blood and toxic material from the body.Cape jasmine, it is bitter, tremble with fear；Return
The heart, lung, tri-jiao channel；Function：Purging intense heat relieving restlessness, reducing fever and causing diuresis, removing pattogenic heat from the blood and toxic material from the body.The present invention is with cordate houttuynia, dandelion, honeysuckle, horse
Bitterroot, cape jasmine directly enter theme to be all adjutant, clearing heat and detoxicating under strong leading of monarch-minister drug, kill virus at one stroke.
Dark plum, it is sour, puckery, put down；Return liver, spleen, lung, large intestine channel；Function：Astringe the lung, puckery intestines, promote the production of body fluid, claming ascaris.Radix glycyrrhizae, it is sweet, put down；
The thoughts of returning home, lung, spleen, stomach；Function：Invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription.Jujube, sweet, temperature；
Returns spleen, stomach；Function：Tonifying middle-Jiao and Qi, nourishing blood and tranquilization.The present invention encourages healthy trends using dark plum, radix glycyrrhizae, jujube as medicine is made, protects liver
It is dirty, make the interacting goals of full side more strong, while coordinating the drug actions of a prescription effect can also be played.
Promoting blood circulation and removing blood stasis, invigorating the spleen dehumidifying, righting nourishing the liver, clearing heat and detoxicating function are played altogether by full side of the invention, to realize to chronic
The conditioning and therapeutic action of hepatitis B.
In the Chinese medicine preparation of the present invention, the weight proportion of each raw material is：Peach kernel 18-26 parts, Buddha's hand 8-15 parts, Fructus Aurantii 8-15
Part, the membrane of a chicken's gizzard 8-15 parts, Semen Coicis 8-15 parts, cordate houttuynia 4-8 parts, dandelion 4-8 parts, honeysuckle 4-8 parts, purslane 4-8 parts,
Cape jasmine 4-8 parts, dark plum 1-4 parts, radix glycyrrhizae 1-4 parts, jujube 1-4 parts.
Optimum ratio is：Peach kernel 20-23 parts, Buddha's hand 9-12 parts, Fructus Aurantii 9-12 parts, the membrane of a chicken's gizzard 9-12 parts, Semen Coicis 9-12 parts,
Cordate houttuynia 6-7 parts, dandelion 6-7 parts, honeysuckle 6-7 parts, purslane 6-7 parts, cape jasmine 6-7 parts, dark plum 2-3 parts, radix glycyrrhizae 2-3
Part, jujube 2-3 parts.
Optimum proportioning is：21 parts of peach kernel, 10 parts of Buddha's hand, 10 parts of Fructus Aurantii, 10 parts of the membrane of a chicken's gizzard, 10 parts of Semen Coicis, 6 parts of cordate houttuynia,
6 parts of dandelion, 6 parts of honeysuckle, 6 parts of purslane, 6 parts of cape jasmine, 3 parts of dark plum, 3 parts of radix glycyrrhizae, 3 parts of jujube.
The Chinese medicine preparation of the present invention can be prepared into various oral preparations by the common process and auxiliary material of pharmacy of Chinese materia medica.Such as
Capsule, tablet, granule, powder, pill（Including the water-bindered pill, honeyed bolus, dragee, capsule and pill, enteric coated pill or dripping pill）Or oral liquid.
Here is the clinical trial data of Chinese medicine preparation medical treatment chronic hepatitis B of the present invention.
1st, clinical observation object：Select clinical definite（Diagnosis meets the " viral hepatitis that the Xi'an of in September, 2000 meeting is formulated
Control prece " standard；HBeAg (+), serum HBV DNA>5.0E+02 IU/mL.）Chronic hepatitis B patient 50, man
29, female 21, the age, the course of disease was between 2-17 between 18 ~ 45 years old.
2nd, clinical indices：The detection of three systems five is in " great three positive "；HBV-DNA is positive；Abnormal liver function；Without any discomfort disease
Shape or it is weak, receive poor, abdominal distension, hepatalgia；Without any sign or hepatomegaly, splenomegaly.
3rd, treatment method：Take granules medicine of the present invention.Specification：6g/ bags, 30 bags/box.Usage：Sooner or later each two bags, temperature
Boiling water is directly taken after mixing it with water, or fusing is oral.The course for the treatment of：Cycle in June 1, overview 1-2 cycles.
4th, efficacy determination index：HBeAg is cloudy to be turned, the anti-HBe serological conversions of HBeAg/, and HBV-DNA is cloudy to be turned, and liver function recovery is just
Often, sings and symptoms recovers normal.
5th, treatment results：Treatment results are shown in Table 1.
Above-mentioned clinical detection as shown by data, Chinese medicine preparation of the invention are improving sings and symptoms, are improving liver function, hepatitis B
Virus e antigen (HBeAg) negative conversion rate, the anti-HBe frequence of seroconversion of HBeAg/, hepatitis B DNA (HBV-DNA) turn
There is clear and definite advantage in terms of cloudy rate.In addition, the full side of Chinese medicine preparation of the present invention uses the raw material of integration of drinking and medicinal herbs, without any toxicity and side effects,
Avoid prior art treatment and injury with present situation, provided for vast chronic hepatitis B patient a kind of safe without wound
Harmful medicine.
Embodiment
The raw material proportioning of medicine of the present invention, preparation and usage are described further below by specific embodiment.
The preparation of embodiment 1, granules medicine
Composition of raw materials：21 parts of peach kernel, 10 parts of Buddha's hand, 10 parts of Fructus Aurantii, 10 parts of the membrane of a chicken's gizzard, 10 parts of Semen Coicis, 6 parts of cordate houttuynia, Pu
Public 6 parts of English, 6 parts of honeysuckle, 6 parts of purslane, 6 parts of cape jasmine, 3 parts of dark plum, 3 parts of radix glycyrrhizae, 3 parts of jujube；
Preparation technology：The common process of granule is prepared by pharmacy and specifications are prepared in auxiliary material：6g/ bags；
Usage and dosage：Sooner or later each 12g, warm boiled water or fusing are oral；6 months 1 cycles, overview 1-2 cycles.
The preparation of embodiment 2, capsule medicine
Composition of raw materials：23 parts of peach kernel, 12 parts of Buddha's hand, 12 parts of Fructus Aurantii, 12 parts of the membrane of a chicken's gizzard, 12 parts of Semen Coicis, 7 parts of cordate houttuynia, Pu
Public 7 parts of English, 7 parts of honeysuckle, 7 parts of purslane, 7 parts of cape jasmine, 3 parts of dark plum, 3 parts of radix glycyrrhizae, 3 parts of jujube；
Preparation technology：The common process of capsule is prepared by pharmacy and auxiliary material is prepared.Specification：Every 0.3g；
Usage and dosage：Sooner or later each 1.5g, warm water are directly taken after mixing it with water；6 months 1 cycles, overview 1-2 cycles.
The preparation of embodiment 3, tablet medicine
Composition of raw materials：20 parts of peach kernel, 9 parts of Buddha's hand, 9 parts of Fructus Aurantii, 9 parts of the membrane of a chicken's gizzard, 9 parts of Semen Coicis, 6 parts of cordate houttuynia, dandelion 6
Part, 6 parts of honeysuckle, 6 parts of purslane, 6 parts of cape jasmine, 2 parts of dark plum, 2 parts of radix glycyrrhizae, 2 parts of jujube；
Preparation technology：The common process of tablet is prepared by pharmacy and auxiliary material is prepared.Specification：Every 1.0g；
Usage and dosage：Sooner or later each 5.0g, warm water are directly taken after mixing it with water；6 months 1 cycles, overview 1-2 cycles.
The preparation of embodiment 4, pill medicine
Composition of raw materials：18 parts of peach kernel, 8 parts of Buddha's hand, 8 parts of Fructus Aurantii, 8 parts of the membrane of a chicken's gizzard, 8 parts of Semen Coicis, 4 parts of cordate houttuynia, dandelion 4
Part, 4 parts of honeysuckle, 4 parts of purslane, 4 parts of cape jasmine, 1 part of dark plum, 1 part of radix glycyrrhizae, 1 part of jujube；
Preparation technology：The common process of pill is prepared by pharmacy and auxiliary material is prepared.Specification：Every 0.05g；
Usage and dosage：Sooner or later each 5.0g, warm water are directly taken after mixing it with water；6 months 1 cycles, overview 1-2 cycles.
The preparation of embodiment 5, oral liquid
Composition of raw materials：26 parts of peach kernel, 15 parts of Buddha's hand, 15 parts of Fructus Aurantii, 15 parts of the membrane of a chicken's gizzard, 15 parts of Semen Coicis, 8 parts of cordate houttuynia, Pu
Public 8 parts of English, 8 parts of honeysuckle, 8 parts of purslane, 8 parts of cape jasmine, 4 parts of dark plum, 4 parts of radix glycyrrhizae, 4 parts of jujube；
Preparation technology：The common process of oral liquid is prepared by pharmacy and auxiliary material is prepared.Specification：Every bottle of 10ml；
Usage and dosage：Sooner or later each 30ml, warm water are directly taken after mixing it with water；6 months 1 cycles, overview 1-2 cycles.
In the various embodiments described above, each raw material proportioning is in parts by weight.
Claims (4)
1. a kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B, is with peach kernel, Buddha's hand, Fructus Aurantii, the membrane of a chicken's gizzard, Semen Coicis, fish raw meat
Grass, dandelion, honeysuckle, purslane, cape jasmine, dark plum, radix glycyrrhizae, jujube are raw material, by the common process of pharmacy of Chinese materia medica and auxiliary
Material is prepared into various oral preparations；Each raw material is matched by following parts by weight：Peach kernel 18-26 parts, Buddha's hand 8-15 parts, trifoliate orange
Shell 8-15 parts, the membrane of a chicken's gizzard 8-15 parts, Semen Coicis 8-15 parts, cordate houttuynia 4-8 parts, dandelion 4-8 parts, honeysuckle 4-8 parts, purslane 4-
8 parts, cape jasmine 4-8 parts, dark plum 1-4 parts, radix glycyrrhizae 1-4 parts, jujube 1-4 parts.
2. it is used for the Chinese medicine preparation for recuperating under medical treatment chronic hepatitis B as claimed in claim 1, it is characterised in that：Each raw material press with
Lower parts by weight are matched：Peach kernel 20-23 parts, Buddha's hand 9-12 parts, Fructus Aurantii 9-12 parts, the membrane of a chicken's gizzard 9-12 parts, Semen Coicis 9-12 parts, fish
Raw meat grass 6-7 parts, dandelion 6-7 parts, honeysuckle 6-7 parts, purslane 6-7 parts, cape jasmine 6-7 parts, dark plum 2-3 parts, radix glycyrrhizae 2-3 parts,
Jujube 2-3 parts.
3. it is used for the Chinese medicine preparation for recuperating under medical treatment chronic hepatitis B as claimed in claim 1, it is characterised in that：Each raw material press with
Lower parts by weight are matched：21 parts of peach kernel, 10 parts of Buddha's hand, 10 parts of Fructus Aurantii, 10 parts of the membrane of a chicken's gizzard, 10 parts of Semen Coicis, 6 parts of cordate houttuynia, Pu
Public 6 parts of English, 6 parts of honeysuckle, 6 parts of purslane, 6 parts of cape jasmine, 3 parts of dark plum, 3 parts of radix glycyrrhizae, 3 parts of jujube.
4. it is used for the Chinese medicine preparation for recuperating under medical treatment chronic hepatitis B as claimed in claim 1, it is characterised in that：The oral preparations are
Capsule, tablet, granule, medicinal tea, pill or oral liquid.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410744916.8A CN104491574B (en) | 2014-12-09 | 2014-12-09 | A kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410744916.8A CN104491574B (en) | 2014-12-09 | 2014-12-09 | A kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104491574A CN104491574A (en) | 2015-04-08 |
| CN104491574B true CN104491574B (en) | 2018-01-12 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201410744916.8A Active CN104491574B (en) | 2014-12-09 | 2014-12-09 | A kind of Chinese medicine preparation for being used to recuperate under medical treatment chronic hepatitis B |
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Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106620389A (en) * | 2016-12-28 | 2017-05-10 | 陕西红顶名医堂药业有限公司 | Traditional Chinese medicine composition for treating chronic hepatopathy and preparation method of traditional Chinese medicine composition |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113779A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Anti- hepatitis B preparation |
| CN1421234A (en) * | 2002-12-13 | 2003-06-04 | 郭言勋 | Oral liquid for treating hepatitis B |
| CN1559532A (en) * | 2004-02-23 | 2005-01-05 | 高和平 | Chinese medicinal mixture for treating viral hepatitis |
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2014
- 2014-12-09 CN CN201410744916.8A patent/CN104491574B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113779A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Anti- hepatitis B preparation |
| CN1421234A (en) * | 2002-12-13 | 2003-06-04 | 郭言勋 | Oral liquid for treating hepatitis B |
| CN1559532A (en) * | 2004-02-23 | 2005-01-05 | 高和平 | Chinese medicinal mixture for treating viral hepatitis |
Non-Patent Citations (1)
| Title |
|---|
| 三清乙肝胶囊治疗慢性乙型肝炎124例临床观察;阳义城等;《湖南中医学院学报》;19970930;第17卷(第3期);11-13 * |
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| CN104491574A (en) | 2015-04-08 |
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