CN104338051A

CN104338051A - Traditional Chinese medicine composition for treating child virus diarrhea

Info

Publication number: CN104338051A
Application number: CN201310332211.0A
Authority: CN
Inventors: 董幼祺; 董继业; 吴明杰
Original assignee: Individual
Current assignee: Individual
Priority date: 2013-08-01
Filing date: 2013-08-01
Publication date: 2015-02-11

Abstract

The invention relates to a traditional Chinese medicine composition for treating child virus diarrhea. The traditional Chinese medicine composition comprises nine kinds of medicines including fried coptis chinensis, fried honeysuckle flowers, lotus leaves, coats of hyacinth beans, smoked plum, fried pomegranate bark, raw liquorice, Chinese yam and roasted malt. The traditional Chinese medicine composition gives consideration to both symptoms and root causes, has the effects of nourishing yin to benefitting spleen and elevating clear qi to lower turbid qi, is good in clinical application effect, has no untoward effect, can shorten the courses of diseases, has the rapid antidiarrheic effect, further can prevent the states of the diseases from being further developed and prompt recovery of the spleen and stomach functions; severe acute disease toxicity diarrhea occurrence rate is lowered; the sick child compliance is good; the price is reasonable; and as for numerous toxicity diarrhea sick children, the traditional Chinese medicine composition has the considerable market potential and social benefits.

Description

A kind of Chinese medicine composition for the treatment of child virus diarrhea

Technical field

The invention belongs to field of traditional Chinese medicine technology, specifically a kind of Chinese medicine for the treatment of child virus diarrhea.

Background technology

Children's diarrhea vein be caused by multiple cause of disease, many factors increase with times of defecation the digestive tract disease changing into feature with stool, the second largest reason [ParasharUD causing less than the 5 years old death of child in the whole world, Gibson CJ, Bresse JS, etal.Rotavirus and severe childhood diarrhea [J] .Emerg InfectDis, 2006,12 (2): 304-306.].In China, the infant of annual trouble Diarrhea Caused by Porcine rotavirus also has about 1,800 ten thousand, the death caused can reach 3 ~ 40,000 [Nie Qinghe. infectious diarrhea present Research [J]. Chinese practical internal medicine journal, 2003,23 (10): 631-633.].Because of the sickness rate of infantile autumn diarrhea and mortality rate high, therefore how to prevent and treat the hot issue that the generation of primary disease and development are medical domain research always.The treatment determined curative effects such as current doctor trained in Western medicine employing intestinal mucosa protective agent, microbial ecological agent and zinc supplement [Tan Fangzhi. treatment of medilac-vita rotavirus enteritis observation of curative effect [J]. theory of medicine and practice, 2009,22(12): 1461.; Zhang Yan. ribavirin combination Lysinepuzinc granule therapy infantile chronic diarrhea clinical observation [J]. Chinese community doctor, 2012,14(11): 107,109.], but in anti-RV cause of disease medicine, there is no comparatively ideal selection at present, adopt virazole more clinically, because it is too strong to viral Adenosine kinase dependency, easily produce drug resistance, and Chang Keyin viral infection and medicament dual effect and occur agranulocytosis, limit the time of its medication.Though western medicine has certain curative effect, Shorten the Treatment Process still seems unable to do what one wants very much to do.From clinical practice, doctor trained in Western medicine liquid make-up, though anti-dehydrating effect is better, anti-diarrhea effect is slow; Single better with treatment by Chinese herbs antidiarrheal effect, but control dehydration (impairment of YIN), its effect is inferior to western medical treatment.

Summary of the invention

The present invention is directed to the deficiencies in the prior art, by clinical practice for many years with from the research of Chinese medical discrimination angle analysis, think that many transformation by diarrhea of heat type of this child virus diarrhea forms, due to pathogenic heat delay, damp and hot unclear, cloudy essence is consumed, cause dysfunction of the spleen in transportation, clear QI failing to ascend, turbid QI failing to descend.Therefore in doctor trained in Western medicine liquid make-up, prevent on the basis of dehydration, take decoction treatment antidiarrheal in yin nourishing activating the spleen, ascending the clear and descending the turbid, obviously can shorten the course of disease, reduce complication, promote the recovery of taste and entirety, disclose a kind of Chinese medicine composition for the treatment of child virus diarrhea for this reason.

Realizing technical scheme of the present invention is: a kind of Chinese medicine composition for the treatment of child virus diarrhea, is characterized in that: be formed by the preparation of raw material of following portions by weight: Rhizoma Coptidis (parched) 1-2.5g; Fry Flos Lonicerae 5-10g; Folium Nelumbinis 6-12g; Testa dolichoris 6-12g; Fructus Mume 3-10g; Fry Pericarpium Granati 5-10g; Radix Glycyrrhizae 3-5g; Rhizoma Dioscoreae 6-12g; Fructus Hordei Germinatus (parched) 6-12g.

As preferably, the optimum proportioning of each raw material of formula of the present invention is: Rhizoma Coptidis (parched) 1.5g; Fry Flos Lonicerae 5g; Folium Nelumbinis 10g; Testa dolichoris 10g; Fructus Mume 5g; Fry Pericarpium Granati 5g; Radix Glycyrrhizae 3g; Rhizoma Dioscoreae 10g; Fructus Hordei Germinatus (parched) 10g.

Component analysis: the present invention is made up of Rhizoma Coptidis (parched), stir-fry Flos Lonicerae, Folium Nelumbinis, Testa dolichoris, Fructus Mume, stir-fry Pericarpium Granati, Radix Glycyrrhizae, Rhizoma Dioscoreae, Fructus Hordei Germinatus (parched) 9 taste medicine.Ancient times and modern pharmacological research show:

Rhizoma Coptidis (parched) has heat clearing and damp drying, eliminating fire and detoxication effect, and resisting pathogenic microbes, antiinflammatory, the pharmacotoxicological effect such as antipyretic;

Fry Flos Lonicerae and there is heat-clearing toxin-expelling functions, and be apt to away middle Jiao and edema caused by disorder of QI after concocting, through modern pharmacology research discovery, there is multiple active ingredient, there is antibacterial, antiviral, suppression ulcer, strengthen the effects such as immunologic function;

Folium Nelumbinis has clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis, for summer-heat excessive thirst, diarrhea due to summer heat and dampness, diarrhea due to hypofunction of the spleen etc., containing multiple alkaloid and vitamin C, polysaccharide such as nuciferine (Roemerine), miltanthin (Pronuciferine) and nuciferine (Nuciferine), also have effect for reducing blood fat;

Testa dolichoris has invigorating the spleen for eliminating dampness effect, with controlling dysentery, diarrhoea etc., has Detoxication to the vomiting, acute gastritis etc. that alimentary toxicosis causes;

Fructus Mume has astringes the lung, and astringing intestine to stop diarrhea, promotes the production of body fluid, relieving colic caused by ascaris effect, and modern pharmacology research finds its resisting pathogenic microbes, shrinks the effect of intestinal wall, still can enhancing human body immunity function;

Fry Pericarpium Granati and have astringing intestine to stop diarrhea, hemostasis, the merit of anthelmintic, with controlling chronic diarrhea, the diseases such as chronic dysentery, have antibacterial, antivirus action, and astriction;

Radix Glycyrrhizae has the function of antiinflammatory and antiallergic action, and stomach mucus can be promoted to be formed and secretion, extend the epithelial cell life-span, have anti-inflammatory activity, the flavone of Radix Glycyrrhizae has antiinflammatory, spasmolytic and antiacid effect;

Rhizoma Dioscoreae has supplementing QI and nourishing YIN, and spleen reinforcing lung kidney, has preventive and therapeutic action to experimental rat model of spleen deficiency, has stronger facilitation to mouse cell immunologic function and humoral immunization;

Fructus Hordei Germinatus (parched) promote qi circulation digestion promoting, spleen benefiting and stimulating the appetite effect, has digestion-aid effect, and Fructus Hordei Germinatus decoct seemingly has slight facilitation to gastric acid and pepsic secretion;

Quan Fanghe and with it, Rhizoma Coptidis (parched) in side, fry Flos Lonicerae heat clearing and damp drying, bowel relieving antidiarrheal; Fructus Mume, stir-fry Pericarpium Granati convergence astringing intestine to stop diarrhea, energy reinforcing stomach reg fluid of holding concurrently; Folium Nelumbinis, Testa dolichoris, Chinese yam spleen-strengtheningporridge the lucid yang sending up; Fructus Hordei Germinatus (parched) promoting digestion and removing stagnation; Radix Glycyrrhizae can pathogenic fire purging, also can coordinating the actions of various ingredients in a prescription, and full side's compatibility gathers effect of yin nourishing activating the spleen, ascending the clear and descending the turbid altogether.

Feature of the present invention is:

1, from Chinese medical discrimination angle analysis, viral diarrhea is divided into just, in, rear three phases.Initial stage is based on damp and hot tired spleen; Mid-term, it was main that cloudy Tianjin has been hindered with damp and hot delay; Later stage is with impairment of YIN, or negative and positive two wound is main.But along with the development of medical science and the improvement of condition of seeking medical advice, the later stage type of this disease obviously reduces, and the damp and hot delay in mid-term, cloudy Tianjin has been hindered type case and has been increased.Many transformation by diarrhea of heat type forms this pattern of syndrome infant, and due to pathogenic heat delay, damp and hot unclear, cloudy essence is consumed, and causes dysfunction of the spleen in transportation, clear QI failing to ascend, turbid QI failing to descend.

2, the damp and hot double impairment of YIN pattern of syndrome of child virus diarrhea belongs to the traditional Chinese medical science and to have loose bowels one of differentiation of symptoms and signs for classification of syndrome, adopt Chinese medicine associating doctor trained in Western medicine fluid-supplement therapy, in doctor trained in Western medicine liquid make-up, prevent on the basis of dehydration, take decoction treatment antidiarrheal in yin nourishing activating the spleen, ascending the clear and descending the turbid, obviously can shorten the course of disease, reduce complication, promote the recovery of taste and entirety, both therapeutic alliance viral diarrheas serve the effect of mutual supplement with each other's advantages, disease is early become rehabilitation, and establishing 3 days is a course for the treatment of;

3,9 taste Chinese medicines are adopted to set up the Chinese medicinal formulae of yin nourishing activating the spleen, ascending the clear and descending the turbid, to take in process and to have no untoward reaction, Chinese medicine participates in treatment can anti-diarrhea effect faster, shorten the course of disease, can also prevent the state of an illness from further developing and impel spleen and stomach function to recover, reduce the incidence rate of Acute critical diseases virus diarrhea, there is effect of yin nourishing activating the spleen, ascending the clear and descending the turbid, have no side effect, infant compliance is good, reasonable price, it, in the face of numerous viral diarrhea infant, has sizable market potential and social benefit.

Compared with prior art, the present invention has following beneficial effect: have no untoward reaction in process of clinical application, the present invention can shorten the course of disease, there is anti-diarrhea effect faster, can also prevent the state of an illness from further developing and impel spleen and stomach function to recover, reduce the incidence rate of Acute critical diseases virus diarrhea, prescription giving consideration to both the incidental and fundamental of the present invention, there is effect of yin nourishing activating the spleen, ascending the clear and descending the turbid, have no side effect, infant compliance is good, reasonable price, it, in the face of numerous viral diarrhea infant, has sizable market potential and social benefit.

Detailed description of the invention

Below in conjunction with embodiment, the present invention is described in further detail.

Raw material is taken by following proportioning:

Prescription: Rhizoma Coptidis (parched) 1.5g; Flos Lonicerae 5g; Folium Nelumbinis 10g; Testa dolichoris 10g; Fructus Mume 5g; Fry Pericarpium Granati 5g; Radix Glycyrrhizae 3g; Rhizoma Dioscoreae 10g; Fructus Hordei Germinatus (parched) 10g.

Manufacturing process of the present invention is: prepared in proportion by above-mentioned dry medical material, and removing impurity, is decocted in water for oral dose, every day potion, add water 200ml, densely decocts 60 ~ 100ml, gradation decoction being taken warmly, within 3 days, is a course for the treatment of.

One, clinical data

1, diagnostic criteria

The diagnosis basis of having loose bowels with reference to " the TCM Pediatrics disease Standardization of diagnosis and curative effect " of the issue in 1994 of " pediatrics " the 7th edition viral enteritis and State Administration of Traditional Chinese Medicine is formulated, and requires to possess following 4 points:

1) 6 months ~ 2 years old age; The course of disease is less than 3; Diarrhoea number of times every day more than 6 times, even tens of times; Stool in yellow or yellow green watery stool, not containing pus and blood and mucus, sometimes in white rice water sample or egg soup sample just, or color is brown and smelly, can have a small amount of mucus.Or with upper respiratory tract infection symptoms and Nausea and vomiting, stomachache, heating, thirsty etc.;

2) there are excess in feeding, unhygienic diet or experience the medical history of seasonal pathogen;

3) diarrhoea and vomiting more severe case, visible oliguria, body temperature raise, excessive thirst god withers, skin is shrivelled, sunken fontanel, order pearl is sunk, crying without tears, lip cherry are red, abdominal distention, and the few Tianjin of red tongue with yellow fur or tongue be the disease such as slightly dry less;

4) stool routine examination: the yellow water sample of outward appearance, microscopy is without special, or visible a small amount of leukocyte; Stool is cultivated and grows without pathogenic bacterium; Etiological examination: use feces Enzyme-linked Immunosorbent Assay rotavirus diagnostic kit (ELLSA) to make wheel virus antigen tests positive during the course of disease 1 ~ 3 day.

The state of an illness is classified:

With reference to Chinese diarrhoeal diseases diagnoses and treatment scheme (Chinese practical department of pediatrics magazine, 1998,13 (6): 381).

Light-duty: without dehydration, without poisoning symptom.

Medium-sized: light, moderate dehydration or have calomel poisoning symptom.

Heavy: severe dehydration or obviously poisoning symptom (agitation, lethargy, drowsiness, pale complexion, Gao Re or body temperature do not rise, peripheral leukocytes counts and obviously increase).

2, Standards of Chinese Medical Syndrome Differentiation

TCM syndrome diagnostic criteria (formulate by " TCM syndrome diagnostic criteria of having loose bowels " with reference in May, 2002 China Medical Science Press " new Chinese medicine guideline of clinical investigations " (trying).）

Primary symptom: recurrent exerbation of 1. having loose bowels, rushes down urgently lower, stool water sample or as egg soup sample, and amount is frequency repeatedly, slightly acid smell or see a little mucus; 2. xerosis cutis, crying without tears; 3. oliguria, even anuria; 4. red lip and slightly dry; 5. red tongue, the few Tianjin of yellow fur or tongue slightly dry less; 6. rolling pulse is counted accurately.

Secondary disease: 1. spiritlessness and weakness; 2. thirst and drinking; 3. fever and irritability; 4. indigestion and loss of appetite; 5. nausea and vomiting; 6. distention and fullness in the abdomen; 7. orbit or sunken fontanel.

Damp-heat and impairment of yin type serious primary symptom 3 (1. 5. indispensable), adds time disease 1; Or primary symptom 2 (1. 5. indispensable), add time disease 2, namely diagnosable.

3, inclusive criteria

1. the person that meets TCM syndrome diagnostic criteria.2. meet Western medicine diagnose standard and the state of an illness to classify medium-sized person.3. the age is birth latter 6 months to 2 years old (containing 2 years old).4. do not used any related anti-viral medicine since onset, comprising: the Chinese medicine, ribavirin, acyclovir, ganciclovir, interferon etc. of various dosage form.

4, exclusion standard

1. the person that do not meet TCM syndrome diagnostic criteria, as pattern of syndrome belongs to the case of simple damp-heat syndrome, impairment of YIN card or dialectical other pattern of syndrome of genus.2. Western medicine diagnose standard person is not met, the diarrhoea caused by other specified pathogen bacterium or the case of dysentery, the case of functional diarrhea.3., in observation therapeutic process, patient adds other associated treatment medicine and methods voluntarily, comprises acupuncture external treatment etc.4. that have related anti-viral medication history after morbidity or take other drug in Ureteral Calculus process voluntarily patient.5. merge disease, primary immunodeficiency disorder and spirit, the sacred disease infants such as cardiovascular and cerebrovascular vessel, Liver and kidney and hemopoietic system, being in a bad way can not oral drugs person.

5, the coming off and process of case

Selected case load reduces expulsion rate as far as possible, all cases that comes off all will clearly be recorded reason, be come off the time, if experimenter does not come in time during institute's further consultation, then by the inquiry such as phone, mail reason, investigate the situation that it gives up the study of, and carry out clinical evaluation when clinical research is withdrawn from experimenter midway.

6, the termination of case is studied

The one of following situation is had to stop clinical research: can not therapist be adhered to; There is serious adverse events/untoward reaction; Other serious complication is there is or sb.'s illness took a turn for the worse person in clinical research process, the reason that researcher reply research stops and the relation conscientiously record with clinical research, corresponding clinical assessment must be carried out when experimenter stops clinical research, the data stopped after clinical research carries out statistical disposition with conservative method of giving way, namely treatment group is by invalid, and matched group is by effectively.

Two, Therapeutic Method

1, research design

Follow the principle of random controls.

2, group technology

Choose and meet being in hospital and outpatient service viral diarrhea infant 200 example of inclusive criteria, be divided into treatment group and each 100 examples of matched group according to random assortment principle, give corresponding treatment by group.

3, administrated method

Two groups of infants all give fluid infusion, maintain on the basis of the conventional therapies such as water, electrolyte, acid-base balance, it is important oral that treatment group gives the present embodiment formula, matched group gives ribavirin 10 ~ 15mg/(kgd) add 5%GS intravenous drip, two groups was all 1 course for the treatment of with 3 days, observed one week after treatment.

The present embodiment formula: Rhizoma Coptidis (parched) 1.5g; Fry Flos Lonicerae 5g; Folium Nelumbinis 10g; Testa dolichoris 10g; Fructus Mume 5g; Fry Pericarpium Granati 5g; Radix Glycyrrhizae 3g; Rhizoma Dioscoreae 10g; Fructus Hordei Germinatus (parched) 10g

Top day potion, add water 200ml, densely decocts 60 ~ 100ml, gradation decoction being taken warmly.

Ribavirin injection (Central China, Hubei Pharmaceutical is produced, lot number 20120419)

3, observational technique

Comprise ordinary circumstance, symptom and sign, Routine Test Lab inspection, safety observations project.

1) ordinary circumstance: name, age, sex, medical history, the course of disease, PMI and medication history etc.

2) symptom and sign: abdominal pain and distension, urine volume, body temperature, dehydration are levied, complexion, the mental status, meal situation, stool situation, picture of the tongue etc.

3) Routine Test Lab inspection: routine blood test, urine, stool routine examination, rotavirus antibody measure, stool is cultivated.

4) safety observations project: general physical examination, Liver and kidney merit check.

Any untoward reaction symptom/adverse events that in clinical trial process, close observation may occur, records faithfully, and comprises whole body and local adverse events/untoward reaction.

4, time point is observed

1) medical history, the course of disease, TCM syndrome diagosis, Western medicine diagnose and the state of an illness classify in treatment before record once.

2) symptom and sign, before the treatment and after treatment every day all carry out observing, inspection record, until treatment terminates.

3) routine blood test, urine, stool routine examination detect once before treatment, and stool wheel virus antigen measures before treatment and treatment terminates rear each detection once.

4) untoward reaction and hepatic and renal function inspection: observe after taking and occur with or without untoward reaction such as original exacerbation of symptoms and erythra; And in treatment group random inspection infant, detect the Liver and kidney function that treatment is front and treat after 3 days, mainly comprise serum alanine aminotransferase (ALT), Aspartate aminotransferase (AST), blood urea nitrogen (BUN) creatinine (Cr).

5, clinical syndrome score (to times of defecation, feces character, abdominal distention stomachache, gastral cavity abdomen feeling of fullness, appetite, the mental status, thirsty, urine colo(u)r specification by 0, I, II, III level Four scoring)

Traditional Chinese medical science four diagnostic methods data is all collected before and after all object of observation treatments, mark to its clinical syndrome, standards of grading are with reference to " the common sympton scalar quantization table of having loose bowels " in " clinical research of the new Chinese medicine treatment infantile diarrhea " guideline in May, 2002 China Medical Science Press " new Chinese medicine guideline of clinical investigations " (trying).

6, observation of curative effect

1) clinical efficacy judges

Clinical disease efficacy determination

" guideline of clinical investigations of new Chinese medicine treatment infantile diarrhea " with reference in May, 2002 China Medical Science Press " new Chinese medicine guideline of clinical investigations " (trying) is formulated.

Clinical recovery: in medication 3 days (72h), times of defecation, character and infant symptom, sign, abnormal physical and chemical index recover normal completely.

Effective: in medication 3 days (72h), the number of times of stool obviously reduces (for 1/3 or following of number of times before treatment), and character takes a turn for the better, and symptom, sign, abnormal physical and chemical index are obviously improved.

Effective: in medication 3 days (72h), times of defecation reduces, and for treating less than 1/2 of front number of times, character takes a turn for the better, and symptom, sign, abnormal physical and chemical index make moderate progress.

Invalid: not meet above standard person.

Clinical therapeutic effect of syndrome judges

Clinical recovery: tcm clinical practice symptom, sign disappear or substantially disappear, syndrome integral reduces >=95%.

Effective: tcm clinical practice symptom, sign are obviously improved, syndrome integral reduces >=70%.

Effective: tcm clinical practice symptom, sign all take a favorable turn, syndrome integral reduces >=30%.

Invalid: tcm clinical practice symptom, sign are all not improved, even increase the weight of, syndrome integral reduces less than 30%.

Note: computing formula (nimodipine method) is: (before (before treatment the rear integration of integration-treatment) ÷ treatment integration) × 100%.

Specific experiment result:

Treatment group clinical recovery, efficiently individual quantity are more than matched group, namely prove treatment group treatment effectively.(matched group has been clinically proven effective in cure)

2) safety evaluatio standard

One-level: safety, without any untoward reaction; Safety indexes checks without exception.

Secondary: safer, has mild adverse effects, and not needing to do any process can continue administration; Safety indexes checks without exception.

Three grades: have safety issue, have moderate untoward reaction, or safety indexes there is mile abnormality, after processing, can administration be continued.

Level Four: the termination test because of serious adverse reaction; Or safety indexes inspection is obviously abnormal.

7, statistical procedures

Collect all clinical datas, building database, total data represents with mean ± standard deviation (x ± s), compares the t inspection of employing two groups of independent samples between measurement data group, compares the t inspection adopting paired sample before and after group internal therapy; Enumeration data adopts two independent sample x ²inspection; The rank test of matched-pair design ranked data symbolization, statistical analysis completes by SPSS16.0 software kit.

Three, result of study

1, expected result

1) confirm that child virus diarrhea damp and hot double impairment of YIN pattern of syndrome belongs to the traditional Chinese medical science and to have loose bowels one of differentiation of symptoms and signs for classification of syndrome, and specification supplements its pathogeny and Therapeutic Principle.

2) confirm that the participation treatment of the traditional Chinese medical science can have anti-diarrhea effect faster, shorten the course of disease.

2, scientific value

1) the clinical research to viral diarrhea is rushed down based on damp and hot, and research acute stage to lag phase damp and hot being had concurrently to impairment of YIN pattern of syndrome is less, and this research has filled up that this is blank.

2) fluid infusion of the lucid yang sending up activating the spleen soup associating doctor trained in Western medicine is evaluated to the damp and hot clinical efficacy having the viral diarrhea infant treatment of impairment of YIN concurrently, for integrative therapy child virus diarrhea provides new thinking.

3) specification supplements the differentiation of symptoms and signs for classification of syndrome of viral diarrhea Chinese traditional treatment, diagnostic criteria and Therapeutic Principle, for the differentiation of symptoms and signs for classification of syndrome of damp and hot double impairment of YIN pattern of syndrome provides foundation.

4) further for the development of clinical research and pharmacological research, new drug provides foundation.

3, performance analysis

1) the participation treatment of the traditional Chinese medical science can shorten the course of disease, has anti-diarrhea effect faster, can promote the recovery of spleen and stomach function entirety.

2) traditional Chinese medical science participates in the incidence rate that can reduce Acute critical diseases virus diarrhea, alleviates psychological burden and the pressure of the head of a family, impels disease early recovery.

Claims

1. treat a Chinese medicine composition for child virus diarrhea, it is characterized in that: be formed by the preparation of raw material of following portions by weight: Rhizoma Coptidis (parched) 1-2.5g; Fry Flos Lonicerae 5-10g; Folium Nelumbinis 6-12g; Testa dolichoris 6-12g; Fructus Mume 3-10g; Fry Pericarpium Granati 5-10g; Radix Glycyrrhizae 3-5g; Rhizoma Dioscoreae 6-12g; Fructus Hordei Germinatus (parched) 6-12g.

2. Chinese medicine composition according to claim 1, is characterized in that: the parts by weight proportioning of described raw material is: Rhizoma Coptidis (parched) 1.5g; Fry Flos Lonicerae 5g; Folium Nelumbinis 10g; Testa dolichoris 10g; Fructus Mume 5g; Fry Pericarpium Granati 5g; Radix Glycyrrhizae 3g; Rhizoma Dioscoreae 10g; Fructus Hordei Germinatus (parched) 10g.