CN104771731A

CN104771731A - Traditional Chinese medicine preparation for treating infantile diarrhea

Info

Publication number: CN104771731A
Application number: CN201510161325.2A
Authority: CN
Inventors: 陆开云
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-07
Filing date: 2015-04-07
Publication date: 2015-07-15

Abstract

The invention relates to a traditional Chinese medicine preparation for treating infantile diarrhea. The traditional Chinese medicine preparation is prepared from the following medicinal raw materials in parts by weight: 4-6 parts of flower of hyacinth dolichos, 4-6 parts of pork liver, 1-3 parts of goat bone, 7-9 parts of dark malt, 4-6 parts of pericarpium granati, 4-6 parts of kalimeris, 4-6 parts of purple potato leaf, 4-6 parts of red Chinese date flesh, 1-3 parts of parched hawthorn fruit, 2-4 parts of nightshade root, 4-6 parts of wintercherry, 4-6 parts of liquorice, 2-4 parts of astragalus membranaceus, 1-3 parts of folium artemisiae argyi, 4-6 parts of fructus trichosanthis, 1-3 parts of coptis chinensis, 1-3 parts of uncaria, 1-3 parts of rhizoma zingiberis, 1-3 parts of kaki calyx, 1-3 parts of mint roots, and 1-3 parts of sorghum roots. The traditional Chinese medicine preparation disclosed by the invention has the advantages of being easily available in materials, simple to prepare, low in cost, convenient to use, low in content of harmful component, free from toxic and side effect and obvious in curative effect.

Description

A kind of Chinese medicine preparation being used for the treatment of infantile diarrhea

Technical field

The present invention relates to field of Chinese herbal medicine technology, be specifically related to a kind of Chinese medicine preparation being used for the treatment of infantile diarrhea.

Background technology

Infantile diarrhea, be many cause of diseases, multifactor cause based on diarrhoea one group of disease.Main feature is that times of defecation increases and character changes, can with the symptoms such as heating, vomiting, stomachache and water, electrolyte, acid base imbalance in various degree.Cause of disease can be caused by virus (being mainly human rotavirus and other enterovirus), antibacterial (Escherichia coli, enterotoxigenic E．Coli, Enterohemorrhagic E.coli, enteroinvasive E．Coli and Salmonella typhimurium, campylobacter jejuni, yersinia enterocolitica, S. aureus L-forms etc.), parasite, fungus etc.Enteric flora disturbance caused by extra intestinal infection, abuse of antibiotics, allergy, improper feeding and climatic factor also can cause a disease, and are the commonly encountered diseases of 5 years old Infants Below.Because patient age is less, according to Western medicine Drug therapy, not only baby self feels bad, and the head of a family is also very vexatious.And adopt the side effect of Western medicine Drug therapy also comparatively large, bad to babies.

Summary of the invention

It is simple that technical problem to be solved by this invention is to provide a kind of composition, the safe and reliable Chinese medicine preparation being used for the treatment of infantile diarrhea.

Technical problem to be solved by this invention realizes by the following technical solutions:

Be used for the treatment of a Chinese medicine preparation for infantile diarrhea, the medicament be made up of the crude drug of following weight portion: Flos dolichoris 4-6 part, Hepar Sus domestica 4-6 part, Os Caprae seu Ovis 1-3 part, Fructus Hordei Germinatus (parched to brown) 7-9 part, Pericarpium Granati 4-6 part, Herba Kalimeridis 4-6 part, Rhizoma Steudnerae Henryanae leaf 4-6 part, Fructus Jujubae meat 4-6 part, Fructus Crataegi (parched to brown) 1-3 part, Radix Solani Nigri 2-4 part, Calyx seu fructus physalis 4-6 part, Radix Glycyrrhizae 4-6 part, Radix Astragali 2-4 part, Folium Artemisiae Argyi 1-3 part, Fructus Trichosanthis 4-6 part, Rhizoma Coptidis 1-3 part, Ramulus Uncariae Cum Uncis 1-3 part, Rhizoma Zingiberis 1-3 part, Calyx Kaki 1-3 part, root of Herba Menthae Haplocalycis 1-3 part, Radix Sorghum vulgare Pers. 1-3 part.

Preferred weight part of each crude drug is: Flos dolichoris 5 parts, 5 parts, Hepar Sus domestica, Os Caprae seu Ovis 2 parts, Fructus Hordei Germinatus (parched to brown) 8 parts, Pericarpium Granati 5 parts, Herba Kalimeridis 5 parts, 5 parts, Rhizoma Steudnerae Henryanae leaf, Fructus Jujubae meat 5 parts, Fructus Crataegi (parched to brown) 2 parts, Radix Solani Nigri 3 parts, Calyx seu fructus physalis 5 parts, 5 parts, Radix Glycyrrhizae, the Radix Astragali 3 parts, Folium Artemisiae Argyi 2 parts, Fructus Trichosanthis 3 parts, Rhizoma Coptidis 2 parts, Ramulus Uncariae Cum Uncis 2 parts, Rhizoma Zingiberis 2 parts, Calyx Kaki 2 parts, root of Herba Menthae Haplocalycis 2 parts, Radix Sorghum vulgare Pers. 2 parts.

Another object of the present invention is to provide a kind of method preparing infantile diarrhea Chinese medicine preparation, comprises the steps:

1) each crude drug is taken by prescription parts by weight;

2) above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.

1, usage and consumption:

The dosage of medicine of the present invention depends on the factor such as age, body weight, health status of patient.Instruction: take 2 every day, each 40-60 milliliter, sub-service sooner or later, treatment infantile dyspepsia, severe diarrhea, mild dehydration.

2, invention formulation has carried out a large amount of clinical trials of a large amount of animal acute toxicity tests, long-term toxicity test for animals and disease therapy, drops into the use link of disease therapy provide science and objective foundation to this medicine.Its test method and result of the test are distinguished as follows:

1) animal acute toxicity test is carried out to decoction prepared by the present invention:

Medicine: the crude drug used by the present invention is bought from common Chinese shop and obtained, and its specification meets national Chinese crude drug standard.

Experimental animal: white mice, body weight is at about 50g, and male and female Stochastic choice, is bought by market.

Method and result: get white mice 10, hungry 20 hours, fill with for 5 times by every only every natural gift and feed 40ml, feed one week continuously, observe 10 days, mice is movable normal, non-toxic reaction, without dead.Show that oral liquid is without acute toxicity, clinical medicine dose safety.

2) long-term toxicity test for animals is carried out to decoction prepared by the present invention:

Experimental animal: rat, body weight is at 120-130g, and male and female Stochastic choice, is bought by market.

Method and result: get rat 20, be divided into 2 groups, often organize 10, wherein the 1st group as administration group, feed by filling with for 2 times every every day, each 5-10ml is not etc., 2nd group of diet as a control group, once a day, continuous irrigation is fed 90 days, survey body weight, 24 hours sacrificed by decapitation after last administration, survey blood, routine urinalysis, liver function, renal function, core, the internal organs such as kidney, the change of tissues observed form, observe the effect of dosage, observe diet, movable change, experiment proves that administration group compares without significant change with matched group, equal non-toxic reaction, a kind of safe drugs.

3, diagnostic criteria

1) clinical diagnosis: vomiting, diarrhoea, stool is water sample or egg soup sample, dyspepsia;

2) in order to verify clinical efficacy, this prescription founds children's hospital in Anhui Province and tries out, and by random selecting wherein 50 routine infants, the course for the treatment of is the shortest 2 days, most long-term therapy 5 days.

3) Therapeutic Method: prepare decoction according to the inventive method, takes to infant.

4) efficacy determination: adopt four grade standards;

Recovery from illness clinical improvements rate >=30%, effective clinical improvements rate >=50%, effective clinical improvement rate >=12%, invalid clinical improvements rate >=8%, concrete therapeutic outcome is see table 1.

Table 1

Number of cases	Recovery from illness	Effective	Effectively	Invalid	Effective percentage (%)
						50	15	25	6	4	92

The invention has the beneficial effects as follows: the present invention draws materials easily, make simple, characteristic of low cost, and easy to use, Harmful ingredient content is low, has no side effect, evident in efficacy.

Detailed description of the invention

The technological means realized to make the present invention, creation characteristic, reaching object and effect is easy to understand, below in conjunction with specific embodiment, setting forth the present invention further.

Embodiment 1

Take: Flos dolichoris 5g, Hepar Sus domestica 5g, Os Caprae seu Ovis 2g, Fructus Hordei Germinatus (parched to brown) 8g, Pericarpium Granati 5g, Herba Kalimeridis 5g, Rhizoma Steudnerae Henryanae leaf 5g, Fructus Jujubae meat 5g, Fructus Crataegi (parched to brown) 2g, Radix Solani Nigri 3g, Calyx seu fructus physalis 5g, Radix Glycyrrhizae 5g, Radix Astragali 3g, Folium Artemisiae Argyi 2g, Fructus Trichosanthis 3g, Rhizoma Coptidis 2g, Ramulus Uncariae Cum Uncis 2g, Rhizoma Zingiberis 2g, Calyx Kaki 2g, root of Herba Menthae Haplocalycis 2g, Radix Sorghum vulgare Pers. 2g.Above-mentioned each taste material medicine is mixed being placed in marmite adds water did not have powder, soak after 30 minutes, with slow fire boiling, renew after boiling and decoct 30 minutes, decoct three times altogether, merges three decocting liquids filtrations, obtain decoction.Take 2 every day, each 40-60 milliliter, sub-service sooner or later.

Model case:

Permitted so-and-so, man, 14 months, people from Fengyang County, Anhui Province.Because of heating, diarrhoea egg style just, reaches more than 10 day, uneasiness of crying and screaming, and temperature 39.6 DEG C of having a medical check-up, oliguria, red tongue with yellow fur, fingerprint purple is stagnant.Western medicine diagnose: rotavirus enteritis; Tcm diagnosis: have loose bowels.Give and embodiment of the present invention medicine, twice sub-service sooner or later.After 2 doses, heat is moved back, and times of defecation reduces, then takes 2 doses and consolidated, and all diseases disappear, stool molding.

Lee so-and-so, man, 18 months, people from Fengyang County, Anhui Province.Patient's continuous 2 days diarrhoea, stool is in egg soup sample, and every day more than 10 times, oliguria with reddish urine, thirsty pre-drink, dysphoria, takes Western medicine and have no effect.Give and the embodiment of the present invention 1 medicine afterwards, after 2 doses, only, within the 3rd day, stool is normal for diarrhoea.Follow up a case by regular visits to one week, have no difference.

Virgin so-and-so, female, 6 years old, people from Fengyang County, Anhui Province.Because of eating cold and uncooked food excessively, recurrent diarrhea 2 days, day row more than 8 times.Watery stool, color is yellowish, abdominal distention and pain.Companion feels sick and tells in advance, and thick fur is greasy, and rolling pulse is strong.Disease belongs to taste and loses fortune, pure and impurely loses points.The pre-embodiment of the present invention 1 prescription, takes 2 day, and after taking medicine 1 day, times of defecation reduces to 2 times, following the service 2 days, and stool is normal, transference cure, cures.

More than show and describe ultimate principle of the present invention and principal character and advantage of the present invention.The technical staff of the industry should understand; the present invention is not restricted to the described embodiments; what describe in above-described embodiment and description just illustrates principle of the present invention; without departing from the spirit and scope of the present invention; the present invention also has various changes and modifications, and these changes and improvements all fall in the claimed scope of the invention.Application claims protection domain is defined by appending claims and equivalent thereof.

Claims

1. one kind is used for the treatment of the Chinese medicine preparation of infantile diarrhea, it is characterized in that, the medicament be made up of the crude drug of following weight portion: Flos dolichoris 4-6 part, Hepar Sus domestica 4-6 part, Os Caprae seu Ovis 1-3 part, Fructus Hordei Germinatus (parched to brown) 7-9 part, Pericarpium Granati 4-6 part, Herba Kalimeridis 4-6 part, Rhizoma Steudnerae Henryanae leaf 4-6 part, Fructus Jujubae meat 4-6 part, Fructus Crataegi (parched to brown) 1-3 part, Radix Solani Nigri 2-4 part, Calyx seu fructus physalis 4-6 part, Radix Glycyrrhizae 4-6 part, Radix Astragali 2-4 part, Folium Artemisiae Argyi 1-3 part, Fructus Trichosanthis 4-6 part, Rhizoma Coptidis 1-3 part, Ramulus Uncariae Cum Uncis 1-3 part, Rhizoma Zingiberis 1-3 part, Calyx Kaki 1-3 part, root of Herba Menthae Haplocalycis 1-3 part, Radix Sorghum vulgare Pers. 1-3 part.

2. a kind of Chinese medicine preparation being used for the treatment of infantile diarrhea according to claim 1, it is characterized in that, the medicament be made up of the crude drug of following weight portion: Flos dolichoris 5 parts, 5 parts, Hepar Sus domestica, Os Caprae seu Ovis 2 parts, Fructus Hordei Germinatus (parched to brown) 8 parts, Pericarpium Granati 5 parts, Herba Kalimeridis 5 parts, 5 parts, Rhizoma Steudnerae Henryanae leaf, Fructus Jujubae meat 5 parts, Fructus Crataegi (parched to brown) 2 parts, Radix Solani Nigri 3 parts, Calyx seu fructus physalis 5 parts, 5 parts, Radix Glycyrrhizae, the Radix Astragali 3 parts, Folium Artemisiae Argyi 2 parts, Fructus Trichosanthis 3 parts, Rhizoma Coptidis 2 parts, Ramulus Uncariae Cum Uncis 2 parts, Rhizoma Zingiberis 2 parts, Calyx Kaki 2 parts, root of Herba Menthae Haplocalycis 2 parts, Radix Sorghum vulgare Pers. 2 parts.