CN102698207A - Traditional Chinese medicine composition for treating hepatopathy and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating hepatopathy and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating hepatopathy, particularly infectious hepatitis, hepatitis B, cirrhosis and early hepatic cell carcinoma, and a preparation method of the composition, belonging to the field of traditional Chinese medicine preparation. The traditional Chinese medicine composition is prepared from the materials including the following traditional Chinese medicines in part by weight: 3-5 parts of gardenia jasminoides, 1-2 parts of west flower, 2-4 parts of red ginseng, 2-3 parts of rhizoma cyperi, 3-5 parts of elecampane, 5-7 parts of fresh naze, 4-6 parts of salviae miltiorrhizae, 2-4 parts of radix bupleuri, 3-5 parts of magnolia obavata, 3-5 parts of fructus aurantii, 3-5 parts of endothelium corneum gigeriae galli, 4-5 parts of pseudo-ginseng, 3-5 parts of radix paeoniae alba, 3-5 parts of herba elephantopi, 3-5 parts of rhizoma corydalis, 6-8 parts of fresh turtle shell, 3-5 parts of Chinese angelica, 3-5 parts of rheum officinale, 3-5 parts of swimming bladder, 3-5 parts of sandalwood, 2-3 parts of cornu saigae tataricae, 3-5 parts of golden cypress, 4-6 parts of fingered citron, 3-5 parts of dalbergia wood, 2-3 parts of white atractylodes rhizome, 3-5 parts of concha haliotidis, 2-4 parts of radix curcumae, 5-7 parts of oriental wormwood, 3-5 parts of fructus amomi, 3-5 parts of lindera aggregate, 3-5 parts of toosendan fruit, 2-4 parts of liquorice and 3-5 parts of pinellia ternate.
Description
Technical field
The invention belongs to the Chinese medicine preparation technical field, be specifically related to Chinese medicine composition of a kind of treatment hepatopathy, especially infectious hepatitis, Type B viral hepatitis, liver cirrhosis, early hepatocarcinoma and preparation method thereof.
Background technology
Hepatopathy belongs to one of current human pertinacious disease that is difficult to cure of generally acknowledging.The general health people is infecting hepatitis virus more than half a year, and virus does not obtain in time thoroughly killing and causes hepatopathy.Infectious hepatitis and Type B viral hepatitis majority are by acute icteric and anicteric hepatitis and change into.Hepatitis virus makes sufferer's liver function impaired, and liver blood vessel and gallbladder blood vessel can not be carried out normal function, causes the patient categories such as " jaundice ", " strongly fragrant disease ", " association's pain ", " gathering " to occur.Part patient's pathogenesis etiology is the infant early infection with adult's extrinsic factor and infected hepatitis virus; Cause infectious hepatitis and Type B viral hepatitis; Because of getting in the body, the infective virus antibacterial causes patient's immunity degradation; This virus and bacteria holes up in the body for a long time, causes many hepatitis b virus carriers to be transformed into liver cirrhosis and early hepatocarcinoma.
Summary of the invention
(1) function with cure mainly: this side adopt in the ancient traditional Chinese medical science the theory of yin-yang and five elements (metal, wood, water, fire and earth) " the liver belonging to wood, demand irrigation it, native cultivation " principle.Through heat-clearing and toxic substances removing, the function of gallbladder promoting dehumidifying, liver-smoothing, qi-regulating, blood circulation promoting and blood stasis dispelling falls enzyme and turns out cloudy, and impels liver cell regeneration.This medicine cures mainly because of glutamate pyruvate transaminase and glutamic oxaloacetic transaminase, GOT rising genus traditional Chinese medical science stasis of blood resistance channels, and the surface antigen index raises, and the infectiousness hepatopath that surplus heresy is unclear has obvious curative effects after especially the hepatopathy patient with severe symptoms being taken medicine.To the effective kill virus of liver cirrhosis and early hepatocarcinoma, repair the effect of short its cell regeneration of hepatocyte, make reversing liver cirrhosis, the purpose that liver is got well.
This medicament stock adopts pure Chinese herbal medicine to process, and to hepatopathy, especially infectious hepatitis, Type B viral hepatitis, liver cirrhosis and early stage liver cancer patient have significant curative effect.The patient took medicine one month, no matter was which kind of hepatopathy, and glutamate pyruvate transaminase and glutamic oxaloacetic transaminase, GOT all can descend, and the surface antigen index also obviously descends, and the patient is almost recovered after taking medicine four months.Hepatitis b virus carrier (great three positive) 95% or more realized after taking medicine four months that as not suffering from other type disease simultaneously transaminase's index is normal, and surface antigen is turned out cloudy.
(2) differential diagnosis in tcm analysis: according to the theory of " healthy energy internal memory, heresy can not be done " in the Chinese medicine " institute of heresy gathers, and its gas must be empty "; Cause the intrinsic factor of virus spread type hepatitis to be: seven emotions are disgruntled becomes estranged; Mechanism of qi is strongly fragrant obstructed with, blood fortune, and bar is lost in gasification; Relate to liver and gall, improper diet and overtiredness, undermine taste.Extrinsic factor: experience ailment said due to cold or exposure, accumulate in the turbid damp, make the liver losing its smoothly moving state, dysfunction of the spleen in transportation and pathogenic factor are taken advantage of a weak point in opponent's defence and are done.The comprehensive primary disease of concluding, how by internal injury caused by excess of seven emotions, eating and drinking without temperance, be given to drink, chronic diarrhea chronic dysentery, the long-pending piece of lump in the abdomen, damp and hot gather or reason such as noxious water infection causes, so that trauma liver spleen are involved in kidney and heart failure.Stagnation of liver-QI is the stagnation of QI then, the liver belonging to wood, and the liver failing to dredge the spleen is dysfunction of the spleen in transportation then, is to be incoordination between the liver and spleen, and disease sees that distending pain in the chest and hypochondrium and transformation and transportation of the spleen and stomach are not normal.
(3) traditional Chinese medical science pathological analysis: " qi as the commander of blood, blood being the mother of qi ", the capable then blood of gas is capable, and the stagnation of QI is blood stasis then, and liver property happiness bar reaches catharsis, and the QI and blood stasis then irritability stasis of blood stagnates and to be difficult to catharsis, and the meridians breath is freely so distending pain over the hypochondrium, side of body mass in the abdomen down can occur.Because of damp and hot pathogen can not reach Qinghua outward, visible bitter taste, stringy pulse and puckery symptom, hepatosplenomegaly, distending pain are not moved, and cause that liver cell regeneration reduces or downright bad, and make the hepatopath form liver cirrhosis, ascites, so that pathological changes and can't curing.
Because hepatopathy belongs to one of human pertinacious disease that is difficult to cure of generally acknowledging on the our times, the objective of the invention is to disclose a kind of treatment hepatopathy, especially the Chinese medicine composition of spreading venereal diseases virus hepatitis, liver cirrhosis and early hepatocarcinoma and method for preparing.
(4) clinical efficacy of each Chinese medicine in the prescription: Stigma Croci, Radix Salviae Miltiorrhizae, Radix Ginseng Rubra, Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling in the side; Radix Curcumae, Fructus Aurantii, Rhizoma Cyperi, Cortex Magnoliae Officinalis promoting QI circulation for relieving depression; Give birth to Carapax Trionycis, give birth to Squama Manis softening hardness and resolving stasis eliminating stagnation; Fructus Amomi, the Radix Aucklandiae, Lignum Santali Albi, the Rhizoma Atractylodis Macrocephalae, Radix Notoginseng promoting flow of QI and blood resolving depression stomach function regulating; Radix Bupleuri, Radix Paeoniae Alba nourishing the liver easing the affected liver; Herba Artemisiae Scopariae, Cortex Phellodendri, Fructus Gardeniae heat-clearing and dampness-resolving principal agent; Endothelium Corneum Gigeriae Galli, the Radix Linderae, Radix Et Rhizoma Rhei relieving distension relieving constipation resolving depression; Cornu Saigae Tataricae, Concha Haliotidis, Fructus Citri Sarcodactylis suppressing the hyperactive liver and subsiding YANG relieve dizziness, high fever, infantile convulsions, epilepsy, etc.; Rhizoma Corydalis, Fructus Toosendan pain-alleviating and network vessel-freeing; Rhizoma Pinelliae preventing or arresting vomiting sending down the abnormal ascending QI, Lignum Dalbergiae Odoriferae leads directly to the Liver Channel key medicine; The Radix Gentianae regulating the flow of QI to dissipate blood stasis, function of gallbladder promoting; The Air Bladder pseudosciaenae seu Acipenser passage, nourishing blood makes the function of hepatocyte and blood platelet regenerating; Radix Glycyrrhizae pathogenic fire purging and all hundred medicines.
(5) technical scheme of the present invention
(1) one of the object of the invention provides a kind of Chinese medicine composition, is processed by the raw material that comprises following weight portion:
Fructus Gardeniae 3-5 part; Stigma Croci 1-2 part; Radix Ginseng Rubra 2-4 part; Rhizoma Cyperi 2-3 part; Radix Aucklandiae 3-5 part;
Give birth to Squama Manis 5-7 part; Radix Salviae Miltiorrhizae 4-6 part; Radix Bupleuri 2-4 part; Cortex Magnoliae Officinalis 3-5 part; Fructus Aurantii 3-5 part;
Endothelium Corneum Gigeriae Galli 3-5 part; Radix Notoginseng 4-5 part; Radix Paeoniae Alba 3-5 part; Radix Gentianae 3-5 part; Rhizoma Corydalis 3-5 part;
Give birth to Carapax Trionycis 6-8 part; Radix Angelicae Sinensis 3-5 part; Radix Et Rhizoma Rhei 3-5 part; Air Bladder pseudosciaenae seu Acipenser 3-5 part; Lignum Santali Albi 3-5 part;
Cornu Saigae Tataricae 2-3 part; Cortex Phellodendri 3-5 part; Fructus Citri Sarcodactylis 4-6 part; Lignum Dalbergiae Odoriferae 3-5 part; Rhizoma Atractylodis Macrocephalae 2-3 part;
Concha Haliotidis 3-5 part; Radix Curcumae 2-4 part; Herba Artemisiae Scopariae 5-7 part; Fructus Amomi 3-5 part; Radix Linderae 3-5 part;
Fructus Toosendan 3-5 part; Radix Glycyrrhizae 2-4 part; Rhizoma Pinelliae 3-5 part.
(2) preferred, process by the raw material of following weight portion:
Fructus Gardeniae 3-5 part; Stigma Croci 1-2 part; Radix Ginseng Rubra 2-4 part; Rhizoma Cyperi 2-3 part; Radix Aucklandiae 3-5 part;
Give birth to Squama Manis 5-7 part; Radix Salviae Miltiorrhizae 4-6 part; Radix Bupleuri 2-4 part; Cortex Magnoliae Officinalis 3-5 part; Fructus Aurantii 3-5 part;
Endothelium Corneum Gigeriae Galli 3-5 part; Radix Notoginseng 4-5 part; Radix Paeoniae Alba 3-5 part; Radix Gentianae 3-5 part; Rhizoma Corydalis 3-5 part;
Give birth to Carapax Trionycis 6-8 part; Radix Angelicae Sinensis 3-5 part; Radix Et Rhizoma Rhei 3-5 part; Air Bladder pseudosciaenae seu Acipenser 3-5 part; Lignum Santali Albi 3-5 part;
Cornu Saigae Tataricae 2-3 part; Cortex Phellodendri 3-5 part; Fructus Citri Sarcodactylis 4-6 part; Lignum Dalbergiae Odoriferae 3-5 part; Rhizoma Atractylodis Macrocephalae 2-3 part;
Concha Haliotidis 3-5 part; Radix Curcumae 2-4 part; Herba Artemisiae Scopariae 5-7 part; Fructus Amomi 3-5 part; Radix Linderae 3-5 part;
Fructus Toosendan 3-5 part; Radix Glycyrrhizae 2-4 part; Rhizoma Pinelliae 3-5 part.
(3) more preferably, process by the raw material of following weight portion,
3 parts of Fructus Gardeniae; 1 part of Stigma Croci; 3 parts of Radix Ginseng Rubra; 2 parts of Rhizoma Cyperis; 4 parts of the Radix Aucklandiae;
Give birth to 6 parts of Squama Manis; 5 parts of Radix Salviae Miltiorrhizaes; 3 parts of Radix Bupleuri; 3 parts of Cortex Magnoliae Officinalis; 3 parts of Fructus Aurantiis;
3 parts of Endothelium Corneum Gigeriae Galli; 4 parts of Radix Notoginseng; 3 parts of the Radix Paeoniae Albas; 3 parts of Radix Gentianae; 3 parts of Rhizoma Corydalis;
Give birth to 6 parts of Carapax Trionycis; 3 parts of Radix Angelicae Sinensis; 3 parts of Radix Et Rhizoma Rhei; 3 parts in Air Bladder pseudosciaenae seu Acipenser; 3 parts in Lignum Santali Albi;
3 parts of Cornu Saigae Tataricae; 3 parts of Cortex Phellodendris; 4 parts of Fructus Citri Sarcodactylis; 3 parts of Lignum Dalbergiae Odoriferaes; 2 parts of the Rhizoma Atractylodis Macrocephalaes;
3 parts of Concha Haliotidis; 2 parts of Radix Curcumaes; 5 parts of Herba Artemisiae Scopariaes; 3 parts of Fructus Amomis; 3 parts of the Radixs Linderae;
3 parts of Fructus Toosendans; 2 parts in Radix Glycyrrhizae; 3 parts of the Rhizoma Pinelliaes.
(4) method for preparing of Chinese medicine composition of the present invention and usage:
One of the object of the invention provides the method for preparing of Chinese medicine composition of the present invention, and this Chinese medicine composition can be solid preparation or liquid preparation, and said solid preparation is powder, tablet, capsule, granule or pill; Said liquid preparation is an oral liquid.Each form of Chinese drug method for preparing and usage are following:
Chinese medicine powder: get said medicaments in part by weight raw material, clean oven dry, pulverize, through the 80-100 mesh sieve, sterilization obtains Chinese medicine composition.Each 5 grams, divide and take for 100 times at every day 3 times.
Chinese medicinal capsule agent: the Chinese medicine powder of above-prepared is incapsulated oral each 10 of patient, every day 3 times according to every 0.5 standard that restrains.
Medicine pill: in above-mentioned Chinese medicine powder, add Mel, the part by weight of powder and Mel is about 10: 7, and making pellets by mixing medical powder with honey, every ball weigh 9 grams, each 1 ball, every day 3 times.
Chinese medicine oral liquid: (is example with 500 gram Chinese medicines) pulverized 500 gram Chinese medicines, fully soaks 4 hours with 80 ℃ of hot water of 2000 grams, with 1 hour at a simmer; Leach medicine juice, add 1500 gram water again, 40 minutes at a simmer; Leach medicine juice and mixes, filter Chinese medicine decoction about 900 through 120 mesh sieves and restrain, according to 10 gram/bottle standards with drug juice for the first time; Process the pure Chinese medicine oral liquid of sugar-free through aseptic canning, each 1, every day 3 times.
Chinese medicinal tablet: Chinese medicine powder upward adds stronger syrup or the gelatine size (or wherein any both or three mix use) of starch slurry, bonding force that accounts for powder weight 5%-10%.Use single punch tablet machine or rotary tablet machine to be pressed into the Chinese medicine tablet that specification is 0.55 gram/sheet, the patient once takes 10, every day 3 times.
Chinese medicine granules: the material of getting it filled is pulverized, and puts suitable the decoction in the container, adds suitable quantity of water submergence medical material, behind the immersion suitable time; Be heated to and boil, leach certain hour, separate fried liquid, medicinal residues fried 2-3 time in accordance with the law; Collect each fried liquid, after centrifugalize or sedimentation filter, cryoconcentration to normal concentration (general proportion is about 1: 1); Next day, deposition was complete, filtrate low-temperature evaporation to thick paste shape, oven dry.Process Chinese medicinal granule with the Chinese medicinal granule machine.Specification is every bag 6 gram, every day 3 times.
(5) drug dose of example:
Fructus Gardeniae 15g; Stigma Croci 5g; Radix Ginseng Rubra 15g; Rhizoma Cyperi 10g; Radix Aucklandiae 20g;
Give birth to Squama Manis 30g; Radix Salviae Miltiorrhizae 25g; Radix Bupleuri 15g; Cortex Magnoliae Officinalis 15g; Fructus Aurantii 15g;
Endothelium Corneum Gigeriae Galli 15g; Radix Notoginseng 20g; Radix Paeoniae Alba 15g; Radix Gentianae 15g; Rhizoma Corydalis 15g;
Give birth to Carapax Trionycis 30g; Radix Angelicae Sinensis 15g; Radix Et Rhizoma Rhei 15g; Air Bladder pseudosciaenae seu Acipenser 15g; Lignum Santali Albi 15g;
Cornu Saigae Tataricae 15g; Cortex Phellodendri 15g; Fructus Citri Sarcodactylis 20g; Lignum Dalbergiae Odoriferae 15g; Rhizoma Atractylodis Macrocephalae 10g;
Concha Haliotidis 15g; Radix Curcumae 10g; Herba Artemisiae Scopariae 25g; Fructus Amomi 15g; Radix Linderae 15g;
Fructus Toosendan 15g; Radix Glycyrrhizae 10g; Rhizoma Pinelliae 15g.
Above accumulated dose 530 grams through cleaning oven dry, pulverizing, cross 80-100 mesh sieve, sterilization, obtain Chinese medicine powder 500 grams, divide take for 100 times (adult's amount).
(6) one of the object of the invention provides the method for above-mentioned traditional Chinese medicine composition for treating hepatopathy, and the purposes in the medicine of preparation treatment hepatopathy.Described hepatopathy can be selected from infectious hepatitis, icterohepatitis, hepatitis B, Type B viral hepatitis, liver cirrhosis, early hepatocarcinoma.
Chinese medicine composition of the present invention has following beneficial effect: heat-clearing and toxic substances removing, and jaundice is eliminated in the function of gallbladder promoting dehumidifying; Liver-smoothing, qi-regulating, function of gallbladder promoting dehumidifying, regulating qi to disperse stagnation; Cure mainly that each infectious hepatitis, hepatitis B virus carriers great three positive are turned out cloudy, liver cirrhosis, middle early hepatocarcinoma, to all kinds of hepatitis, liver cirrhosis, middle early hepatocarcinoma has significant curative effect; Short treating period, instant effect has no side effect.The patient took medicine one month, no matter was which kind of hepatopathy, and glutamate pyruvate transaminase and glutamic oxaloacetic transaminase, GOT all can descend, and the surface antigen index also obviously descends, and the patient is almost recovered after taking medicine four months.Hepatitis b virus carrier (great three positive) 95% or more realized after taking medicine four months that as not suffering from other type disease simultaneously transaminase's index is normal, and surface antigen is turned out cloudy.
The specific embodiment:
Embodiment 1:
Chinese medicine composition of the present invention has: blood circulation promoting and blood stasis dispelling, and heat-clearing and toxic substances removing, the function of gallbladder promoting dehumidifying, liver-smoothing, qi-regulating falls enzyme and turns out cloudy, and reaches the function of impelling liver cell regeneration.This test intended is observed the acute toxic reaction of mice to said preparation, reports as follows:
(1) material and method
(1) laboratory animal: the mice in 6～8 ages in week, body weight is in 20 ± 2 grams, 20, male and female half and half (laboratory animal credit number: SYXK (Ji) 2003-0013).
(2) acute toxicity testing: select 6 of Kunming kind white mice for use, male and female half and half, body weight 20 ± 2g.Fasting, can't help water 12～16 hours.Attach vehicle to Chinese medicine and boil concentrated 3 times; Root medicated powder sieves with 100 eye mesh screens.Facing the thick medicated powder that sifts out with preceding handle, filters after 12～16 hours with concentrated vehicle immersion.Be blended in the thin medicated powder that sieves in the filter liquor of vehicle again, form the suspension of Cmax, contain crude drug 428mg/ml.Every mice is irritated stomach at every turn, and to give concentration be this traditional Chinese medicine liquid 5ml/20g (body weight) that contains crude drug 428mg/ml, irritates stomach 2 times in the 24h, 6 hours at interval.Raise by routine then.Observe situation such as mice outward appearance, behavioral activity, breathing, secretions, defecation, death and weighed continuous 7 days.Because of the influence of disappeared cancer-root drug level and volume, single administration is not all measured median lethal dose(LD 50) (LD50) with Cmax, heap(ed) capacity.
(3) maximum dosage-feeding experiment: select 20 of Kunming kind white mice for use, male and female half and half, body weight 20 ± 2g.Make up a prescription, irritate stomach, observation, detection by the preliminary experiment method.After 7 days, mice is weighed, dissect, and pathologic finding important organ (heart, liver, spleen, lung, kidney), and calculate maximum dosage (g/kg.d) in the mice 1 day.
(2) experiment conclusion
Do not measure this Chinese medicine median lethal dose(LD 50) (LD50) with Cmax, heap(ed) capacity, so only do the maximum dosage-feeding experiment.Chinese medicine mice maximum dosage-feeding is 26.87g/kg.d (amounting to crude drug calculates), is equivalent to 13 times (＞100 times) of the clinical daily dosage of people's (body weight is pressed 60kg and calculated).Death does not appear in all administration mices, does not find the clinical manifestation that other are relevant with administration yet, explains that this medicine is nontoxic, and the clinical application amount of this medicine is a safe dose.
Embodiment 2:
(1) diagnosing hepatism standard: reference " virus hepatitis is prevented and treated scheme ", " Clinics and Practices of cirrhosis " (author:
Week ForeverThe Xing chief editor), " modern diagnosing cancer of liver acology " (
Rui JinganThe chief editor) dependent diagnostic standard in the book.
(2) case is included standard in:
1. indagations meet medical science " viral infectious hepatitis ", " liver cirrhosis ", " early hepatocarcinoma " and reach " with the hepatopathy associated cancer " diagnostic criteria in preceding 2 weeks of clinical trial medication.
2. dialectically in 1 week of medication meet differential diagnosis in tcm standard person.
3. age 18-80 one full year of life.
4. preceding 2 weeks of test stop using and once adopted the other treatment method.
(3) case is rejected standard:
1. or 2 the week in acceptance use the other medicines therapist simultaneously.
The patient that 2. can not take medicine on time on request.
3. gestation and women breast-feeding their children.
4. diagnosis suffers from other severe chronic disease patients simultaneously.
5. turn out to be other type hepatitis (ethanol property, drug intoxication hepatitis etc.) on inspection
(4), the test method and the state of an illness, age cohorts:
1. adopt stochastic sampling Comparison of therapeutic scheme.
2. case source and grouping: be actual diagnosis and treatment case, wherein choose test group 315 examples.Divide into groups with the degree that is in a bad way according to sex, classification of diseases.
3. test medication: the present invention treats the Chinese medicinal composition capsules of all kinds of spreading venereal diseases virus hepatitis, liver cirrhosis and early hepatocarcinoma, specification 0.5g/ grain.
(5) administrated method:
1. taking dose: 10 of treatment group capsules of the present invention/inferior, 3 times/day.
2. route of administration: oral, warm water delivery service.
3. treat the course of treatment: 1 month was 1 course of treatment, and the treatment phase was generally 2-4 month, serious symptom 8 months.
(6) observation item and index:
Liver function: (ALT AST TBIL DBIL A/G PT/PA) patients with hepatic function in therapeutic process according to state of an illness periodic review.
(7) curative effect determinate standard: with reference to " the clinical research guideline of new Chinese medicine treatment viral hepatitis " criterion of therapeutical effect and with reference to curative effect determinate standards such as relevant hepatopathy, liver cirrhosis and hepatocarcinoma of narration in " Clinics and Practices of liver cirrhosis " (author: Zhou Yongxing chief editor), " modern diagnosing cancer of liver therapeutics " (Rui Jingan chief editor) book; Divide and cure, cure basically; Effectively, invalid.
Cure: hepatitis: hepatitis symptom disappears, and it is normal that hepatosplenomegaly is recovered, and the hepatic region does not have tenderness, kowtows pain, and liver function test is normal, and HBV infects mark and turns out cloudy.Liver cirrhosis patient: hepatitis interstitialis chronica is softening, and hepatocyte recovers regeneration capacity, and each item index is turned out cloudy, and liver function recovery is normal; Early hepatocarcinoma and associated cancer patient: effectively control cancer cell diffusion and transfer, the hepatocarcinoma lump disappears, and ascites disappears, and the cancerous cell calcification is until disappearance, and liver function recovery is normal, and it is normal that each item index is recovered.Above each item index was stablized more than 5 years.
The basic healing: hepatitis: patient's hepatitis symptom disappears, and it is normal that hepatosplenomegaly is recovered, and the hepatic region does not have tenderness, kowtows pain, and liver function test is normal, and HBV infects mark and turns out cloudy.Hepatitis interstitialis chronica is softening, and hepatocyte recovers regeneration capacity, and each item index is turned out cloudy, and liver function recovery is normal; Early hepatocarcinoma and associated cancer, control cancer cell diffusion and transfer, the hepatocarcinoma lump disappears; Ascites disappears, and the cancerous cell calcification is until disappearance, and liver function recovery is normal; Transference cure, hepatosplenomegaly recover normal, and the hepatic region does not have obvious tenderness and kowtows pain; Liver function test is normal, and HBV infects mark and turns out cloudy, and above each item index was stablized more than 1 year.
Effectively: liver tumor is dwindled, and hepatitis interstitialis chronica is improved, and cardinal symptom disappears, and the hepatosplenomegaly situation alleviates, and no hepatic region does not have obvious tenderness and kowtows pain, and liver function test is normal or than initial value decline 40-50%, each item index was stablized more than 3 months.
Invalid: after finished a course of treatment, ALT is the descender not, the surface antigen no change, and liver cirrhosis does not have improvement, early hepatocarcinoma tumor no change.
(8) efficacy analysis:
Selected number: observe actual case 315 examples altogether, wherein:
Group 1: icterohepatitis; Group 2: Type B viral hepatitis; Group 3: liver cirrhosis;
Group 4: early hepatocarcinoma; Group 5: other and liver associated cancer.
The present invention treats hepatopathy; Especially the Chinese medicine composition of spreading venereal diseases virus hepatitis, liver cirrhosis and early hepatocarcinoma is that differential diagnosis in tcm belongs to the meridian stasis plug; Surplus heresy unclear through proved recipe, be further its curative effect of checking, this is taken up a job as a doctor to cure the disease and divides man, women situation to randomly draw statistical data in the example; Extract case 315 examples altogether, wherein scorching 85 examples of icteric gallbladder; Chronic type B viral hepatitis: 120 examples, liver cirrhosis: 50 examples, early hepatocarcinoma 40 examples, other cases of cancer relevant 20 examples with hepatopathy.This extracts in the case, male's 176 examples, women's 139 examples, mean age: 42.5 years old (18 years old-80 years old).Extract case and during treating, only adopt this Chinese medicine composition to treat, all do not add other liver disease medicines and fall the enzyme medicine, through treatment, above effective percentage reaches more than 95%, and basic cure rate is more than 90%.
Embodiment 3:
Cure hepatopath's instance (seven examples):
Case 1: Xu Changji, the man about 50 years old, was diagnosed as hepatitis B (glutamate pyruvate transaminase 68U/L, glutamic oxaloacetic transaminase, GOT 89U/L, hepatitis B surface antigen 42ng/ml) before 10 years, be in a bad way so that can't work.Its in Jilin Province hepatopathy center treatment had a surplus in two months, fruit does not take effect.Took this medicine one month, the state of an illness greatly takes a turn for the better, index decline (glutamate pyruvate transaminase 28U/L; Glutamic oxaloacetic transaminase, GOT 32U/L, hepatitis B surface antigen 18ng/ml) took this medicine four months, this patient recovers, and (transaminase all drops to 1U/L; Surface antigen is turned out cloudy), do not violate always.
Case 2: Liu Zhong English mother, 78 years old now, Xia Jiadian township, Dehui City, Jilin Province Si Qingzui people from village; Be diagnosed as icteric infectious hepatitis (glutamate pyruvate transaminase 99U/L, glutamic oxaloacetic transaminase, GOT 86U/L, serum bilirubin 25 μ mol/L before 20 years; Urine bilirubin is positive); Obstinate causes the patient whole body and fingernail all to be yellow, reaches more than ten years.The patient takes the jaundice elimination in month of this medicine after the diagnosis state of an illness, and transaminase's index obviously descends, and takes medicine three months, and transaminase and bilirubin are reduced to normally, state of an illness recovery from illness, and two more than ten years did not violate so far.
The outstanding mother of case 3: Wu Yu, 93 years old now, live Changchun automobile factory, old lady is diagnosed as viral hepatitis B the more than ten years before, after change into hepatitis interstitialis chronica, treat and do not heal half a year economizing hepatopathy hospital for infectious diseases.After taking a course of treatment of this medicine (one month), abdominal distention and ascites disappear, and can normally take food after two months.This patient took this medicine seven months continuously, and the transaminase drops to positive ordinary index, and surface antigen is turned out cloudy, and health is good so far.
The rich mother of case 4: Guo Jun, 73 years old now, Heilongjiang Province's Shuangcheng City joined Xing Xiang people from village that jump forever, was diagnosed as hepatobiliary cancer in 2003; Due to illness the serious life of feelings can't be taken care of oneself, and is invalid through how tame hospital treatment, takes this medicine one month; Old lady can take care of oneself, and takes medicine altogether eight months, and patients with hepatic cancerous protuberance piece disappears; Ascites disappears, the cancerous cell calcification, and liver function recovery is normal.
Case 5: Yao Qingjie, man, 36 years old now; Be diagnosed as the B-mode infectious hepatitis of icteric (glutamate pyruvate transaminase 88U/L during he was educated in the university in 2000; Glutamic oxaloacetic transaminase, GOT 97U/L, serum bilirubin 28 μ mol/L, urine bilirubin is positive); Several months fails to cure in hospital, and the patient transaminase fails to lower all the time.Taking month patient paddy third of this medicine all drops to below the 20U/L with glutamic oxaloacetic transaminase, GOT; Serum bilirubin is reduced to 20 μ mol/L; Do two double inspections with this medicine the second month to hospital, only surplus two plus siges, take this medicine after four months transaminase, serum and urine bilirubin return to normally; Recover, do not violate so far.
Case 6: Zhao Chenggong, woman, 48 years old, Harbin City, Heilongjiang Province people from city; She is diagnosed as hepatitis B (glutamate pyruvate transaminase 77U/L, glutamic oxaloacetic transaminase, GOT 89U/L, surface antigen 46ng/ml) before surplus ten year; After due to illness feelings seriously cause heart failure, be unable to leave the bed, though through the hospitalize unsatisfactory curative effect.Take this medicine after one month (transaminase all drops to below the 30U/L, and surface antigen drops to 22ng/ml), it is normal that heart failure recovers.After taking medicine four months, liver function and two double inspections are comprehensively done by the Second Academy in the Harbin City, and transaminase and surface antigen are turned out cloudy, and state of an illness recovery from illness is not violated so far, and health is good.
Case 7: Guan Xirong, the man, 64 years old, people from Acheng, Heilungkiang transferred hepatocarcinoma to after being diagnosed as early stage hepatitis interstitialis chronica in 1996, at that time the obvious abdominal distention of patient, ascites, severe jaundice (transaminase up to more than the 140U/L, surface antigen 88ng/ml).Took this medicine one month, jaundice is eliminated, and the transaminase drops to 50U/L.Take this medicine after two months, diet is normal, no significant reaction.Take this medicine altogether after six months, hepatitis interstitialis chronica disappears, the calcification of early hepatocarcinoma cell, and surface antigen is turned out cloudy, and recovery from illness is not violated so far.
Show that through The above results Chinese medicine composition of the present invention is imitated good and curative effect lasting stability to treatment hepatopathy, especially spreading venereal diseases virus hepatitis, liver cirrhosis and early hepatocarcinoma with the clinical treatment of liver associated cancer, in therapeutic process, not seeing has untoward reaction.
In sum; Only embodying embodiments of the invention, is not that the present invention is done any formal and substantial restriction, allly is familiar with this traditional Chinese medical science specialty person skilled; In not breaking away from technical scheme scope of the present invention; When can utilizing the above technology contents, and a small amount of change of making, modify and the equivalent variations that develops, all can be considered and equivalence enforcement of the present invention; Simultaneously, all foundations essence technology of the present invention all still belongs to the scope of technical scheme of the present invention to the change and the differentiation of any equivalent variations that above embodiment did.
Claims (10)
1. a Chinese medicine composition is processed by the raw material that comprises following weight portion,
Fructus Gardeniae 3-5 part; Stigma Croci 1-2 part; Radix Ginseng Rubra 2-4 part; Rhizoma Cyperi 2-3 part; Radix Aucklandiae 3-5 part;
Give birth to Squama Manis 5-7 part; Radix Salviae Miltiorrhizae 4-6 part; Radix Bupleuri 2-4 part; Cortex Magnoliae Officinalis 3-5 part; Fructus Aurantii 3-5 part;
Endothelium Corneum Gigeriae Galli 3-5 part; Radix Notoginseng 4-5 part; Radix Paeoniae Alba 3-5 part; Radix Gentianae 3-5 part; Rhizoma Corydalis 3-5 part;
Give birth to Carapax Trionycis 6-8 part; Radix Angelicae Sinensis 3-5 part; Radix Et Rhizoma Rhei 3-5 part; Air Bladder pseudosciaenae seu Acipenser 3-5 part; Lignum Santali Albi 3-5 part;
Cornu Saigae Tataricae 2-3 part; Cortex Phellodendri 3-5 part; Fructus Citri Sarcodactylis 4-6 part; Lignum Dalbergiae Odoriferae 3-5 part; Rhizoma Atractylodis Macrocephalae 2-3 part;
Concha Haliotidis 3-5 part; Radix Curcumae 2-4 part; Herba Artemisiae Scopariae 5-7 part; Fructus Amomi 3-5 part; Radix Linderae 3-5 part;
Fructus Toosendan 3-5 part; Radix Glycyrrhizae 2-4 part; Rhizoma Pinelliae 3-5 part.
2. Chinese medicine composition according to claim 1 is processed by the raw material of following weight portion,
Fructus Gardeniae 3-5 part; Stigma Croci 1-2 part; Radix Ginseng Rubra 2-4 part; Rhizoma Cyperi 2-3 part; Radix Aucklandiae 3-5 part;
Give birth to Squama Manis 5-7 part; Radix Salviae Miltiorrhizae 4-6 part; Radix Bupleuri 2-4 part; Cortex Magnoliae Officinalis 3-5 part; Fructus Aurantii 3-5 part;
Endothelium Corneum Gigeriae Galli 3-5 part; Radix Notoginseng 4-5 part; Radix Paeoniae Alba 3-5 part; Radix Gentianae 3-5 part; Rhizoma Corydalis 3-5 part;
Give birth to Carapax Trionycis 6-8 part; Radix Angelicae Sinensis 3-5 part; Radix Et Rhizoma Rhei 3-5 part; Air Bladder pseudosciaenae seu Acipenser 3-5 part; Lignum Santali Albi 3-5 part;
Cornu Saigae Tataricae 2-3 part; Cortex Phellodendri 3-5 part; Fructus Citri Sarcodactylis 4-6 part; Lignum Dalbergiae Odoriferae 3-5 part; Rhizoma Atractylodis Macrocephalae 2-3 part;
Concha Haliotidis 3-5 part; Radix Curcumae 2-4 part; Herba Artemisiae Scopariae 5-7 part; Fructus Amomi 3-5 part; Radix Linderae 3-5 part;
Fructus Toosendan 3-5 part; Radix Glycyrrhizae 2-4 part; Rhizoma Pinelliae 3-5 part.
3. Chinese medicine composition according to claim 2 is processed by the raw material of following weight portion,
3 parts of Fructus Gardeniae; 1 part of Stigma Croci; 3 parts of Radix Ginseng Rubra; 2 parts of Rhizoma Cyperis; 4 parts of the Radix Aucklandiae;
Give birth to 6 parts of Squama Manis; 5 parts of Radix Salviae Miltiorrhizaes; 3 parts of Radix Bupleuri; 3 parts of Cortex Magnoliae Officinalis; 3 parts of Fructus Aurantiis;
3 parts of Endothelium Corneum Gigeriae Galli; 4 parts of Radix Notoginseng; 3 parts of the Radix Paeoniae Albas; 3 parts of Radix Gentianae; 3 parts of Rhizoma Corydalis;
Give birth to 6 parts of Carapax Trionycis; 3 parts of Radix Angelicae Sinensis; 3 parts of Radix Et Rhizoma Rhei; 3 parts in Air Bladder pseudosciaenae seu Acipenser; 3 parts in Lignum Santali Albi;
3 parts of Cornu Saigae Tataricae; 3 parts of Cortex Phellodendris; 4 parts of Fructus Citri Sarcodactylis; 3 parts of Lignum Dalbergiae Odoriferaes; 2 parts of the Rhizoma Atractylodis Macrocephalaes;
3 parts of Concha Haliotidis; 2 parts of Radix Curcumaes; 5 parts of Herba Artemisiae Scopariaes; 3 parts of Fructus Amomis; 3 parts of the Radixs Linderae;
3 parts of Fructus Toosendans; 2 parts in Radix Glycyrrhizae; 3 parts of the Rhizoma Pinelliaes.
4. each described Chinese medicine composition of claim 1-3 is characterized in that this Chinese medicine composition is solid preparation or liquid preparation, and said solid preparation is powder, tablet, capsule, granule or pill; Said liquid preparation is an oral liquid.
5. a method for preparing each described Chinese medicine composition of claim 1-3 with said medicaments in part by weight raw material for washing oven dry, is pulverized, and through the 80-100 mesh sieve, sterilization promptly gets the Chinese medicine composition medicinal powder.
6. a method for preparing each described Chinese medicine composition of claim 1-3 is cleaned oven dry with said medicaments in part by weight, pulverize, and through the 80-100 mesh sieve, sterilization, it is subsequent use to obtain powder; Then this powder is incapsulated, obtain capsule; Or in this powder, adding Mel, the part by weight of powder and Mel is 10: 7, making pellets by mixing medical powder with honey; Or in this powder, add starch slurry, syrup and/or the gelatine size that accounts for powder weight 5%-10%, be pressed into tablet with single punch tablet machine or rotary tablet machine.
7. a method for preparing each described Chinese medicine composition of claim 1-3 is an example with 500 gram Chinese medicines, and the said parts by weight of Chinese traditional medicine of 500 grams is pulverized; Fully soaked 4 hours with 80 ℃ of hot water of 2000 grams,, leach medicine juice with 1 hour at a simmer; Add again 1500 the gram water, 40 minutes at a simmer, leach medicine juice with the first time drug juice mix; Filter about 900 grams of Chinese medicine decoction through 120 mesh sieves, process oral liquid through aseptic canning.
8. a method for preparing each described Chinese medicine composition of claim 1-3 is got said medicinal materials in part by weight and is pulverized, and puts to decoct in the container, adds water to submerge medical material; After soaking suitable time, be heated to and boil, leach certain hour, separate fried liquid; Medicinal residues fried 2-3 time are in accordance with the law collected each fried liquid, after centrifugalize or sedimentation filter; Cryoconcentration is to normal concentration, and general proportion is about 1: 1, and next day, deposition was complete; Filtrate low-temperature evaporation to thick paste shape, oven dry is processed Chinese medicine granules with the Chinese medicinal granule machine.
9. each Chinese medicine composition or the purposes of Chinese medicine composition in the medicine of preparation treatment hepatopathy that obtains with each method for preparing of claim 4-8 of claim 1-3.
10. according to the purposes of claim 9, wherein said hepatopathy is selected from infectious hepatitis, icterohepatitis, hepatitis B, Type B viral hepatitis, liver cirrhosis, early hepatocarcinoma.
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230563A (en) * | 2013-04-19 | 2013-08-07 | 程秀菊 | Medicine for treating cirrhosis |
| CN104147017A (en) * | 2014-07-17 | 2014-11-19 | 新乡医学院 | Medicinal composition for treating liver cirrhosis and application thereof |
| CN105497508A (en) * | 2014-11-07 | 2016-04-20 | 苏珉 | Traditional Chinese medicine for treating chronic hepatitis |
| CN107802809A (en) * | 2017-11-17 | 2018-03-16 | 张淑芳 | A kind of Chinese medicine composition for treating hepatopathy and preparation method thereof |
| CN114470118A (en) * | 2020-10-27 | 2022-05-13 | 谢守信 | A Chinese medicinal composition for treating liver diseases, and its preparation method |
-
2012
- 2012-06-28 CN CN2012102156477A patent/CN102698207A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103230563A (en) * | 2013-04-19 | 2013-08-07 | 程秀菊 | Medicine for treating cirrhosis |
| CN103230563B (en) * | 2013-04-19 | 2014-10-15 | 程秀菊 | Medicine for treating cirrhosis |
| CN104147017A (en) * | 2014-07-17 | 2014-11-19 | 新乡医学院 | Medicinal composition for treating liver cirrhosis and application thereof |
| CN105497508A (en) * | 2014-11-07 | 2016-04-20 | 苏珉 | Traditional Chinese medicine for treating chronic hepatitis |
| CN107802809A (en) * | 2017-11-17 | 2018-03-16 | 张淑芳 | A kind of Chinese medicine composition for treating hepatopathy and preparation method thereof |
| CN114470118A (en) * | 2020-10-27 | 2022-05-13 | 谢守信 | A Chinese medicinal composition for treating liver diseases, and its preparation method |
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Application publication date: 20121003 |