CN103623319B - A kind of medicine for the treatment of chronic persistent hepatitis and preparation method thereof - Google Patents

Abstract

The invention discloses a kind of medicine for the treatment of chronic persistent hepatitis and preparation method thereof, it is mainly prepared from according to a certain weight ratio by medicines such as Ramulus Euonymi, Talcum, Endothelium Corneum Gigeriae Galli, Semen Glycines, Periostracum Cicadae, vinegar, Mel, medicine of the present invention has invigorating the spleen and replenishing QI, calming liver and clearing heat, the function of promoting diuresis to remove toxic substance, be used for the treatment of chronic persistent hepatitis instant effect, good effect, have no side effect.

Description

A kind of medicine for the treatment of chronic persistent hepatitis and preparation method thereof

Technical field

The present invention relates to a kind of medicine being used for the treatment of chronic persistent hepatitis and preparation method thereof, belong to the field of Chinese medicines.

Technical background

Chronic persistent hepatitis refers to that the course of disease exceedes half a year, still protracted course of disease, and symptom, sign and abnormal liver function are comparatively light, without self immune system and the existing hepatitis of other system tables.Patient often occur slightly weak, pain in the hepatic region, appetite are poor, abdominal distention etc., also can non-evident sympton.Often slightly large with liver, spleen sometimes also can enlargement, but without Progressive symmetric erythrokeratodermia enlargement.At present, western medicine chronic persistent hepatitis poor effect, and long-term taking Western medicine has more side effect, therefore, there is very large demand to the Chinese medicine of effectively treating chronic persistent hepatitis in people.

Summary of the invention

The present inventor, according to the research of theory of Chinese medical science and clinical test repeatedly and checking, finally have found the medicine of effectively treatment chronic persistent hepatitis, thus completes the present invention.

Object of the present invention is just to provide a kind of composition of medicine effectively can treating chronic persistent hepatitis.

Another object of the present invention just there is provided the preparation method of this composition of medicine.

Medicine of the present invention selects Ramulus Euonymi, Talcum, Endothelium Corneum Gigeriae Galli, Semen Glycines, Periostracum Cicadae, vinegar, Mel, Testa sojae atricolor, Herba Sedi Sarmentosi, Herba Hyperici Japonici, Rhizoma Paridis, Fructus Ligustri Lucidi, Herba Artemisiae Scopariae, Semen Alpiniae Katsumadai, Oryza glutinosa, Rhizoma Picrorhizae, Herba Phyllanthi Urinariae, Flos Osmanthi Fragrantis, Radix Cynanchi Amplexicaulis, Fel Sus domestica, Radix Codonopsis medicine to combine, each efficacy of drugs is made by these drug regimens to produce synergism, thus can the recurrence of fast treating chronic persistent hepatitis.Wherein select Ramulus Euonymi to be because its nature and flavor are bitter, cold, enter meridian of Foot-JUE YIN, have removing blood stasis, stimulate the menstrual flow, the function of parasite killing, control amenorrhea ， mass in the abdomen, puerperal, stasis of blood band was suffered from abdominal pain, abdominal pain due to worm stagnation.Talcum is selected to be because its nature and flavor are sweet, light, cold, return bladder, lung, stomach warp, have inducing diuresis for treating stranguria syndrome, heat-clearing and toxic substances removing, the function of damp eliminating expelling summer-heat, control hematodiarrhoea, gonorrhea, urinate hot puckery pain, heat-damp in summer excessive thirst, damp and hot watery diarrhea, external treatment eczema, eczema, miliaria.Select Endothelium Corneum Gigeriae Galli to be because its nature and flavor are sweet, flat, enter spleen, stomach warp, control stagnant, the function of strengthening the spleen and stomach, control food stagnation distension, vomiting regurgitation, dysentery, infantile malnutrition, quenches one's thirst, incontinence of urine, sore throat tonsillitis, ulcerative gingivitis aphtha.Semen Glycines is selected to be because its nature and flavor are sweet, flat, there is spleen invigorating alleviating distention in middle-JIAO, moisturize the function of the water that disappears, control infantile malnutrition dysentery, abdominal distention weakness and emaciation, gestosis, sore and toxic, traumatic hemorrhage.Select Periostracum Cicadae to be because its property sweet-salty, cool, enter lung, Liver Channel, have loose wind heat, lung qi dispersing, determine the function of convulsion, control affection due to external wind and heat, cough hoarseness, measles is sent out not smooth thoroughly, and rubella pruritus, little youngster shies Epilepsy, conjunctival congestion, cataracta, furuncle swelling toxin, tetanus.Select vinegar to be that temperature, enters liver, stomach warp, have dissipating blood stasis because its nature and flavor are bitter, hemostasis, removing toxic substances, the function of parasite killing, controls puerperal blood faints, spits blood, epistaxis, pudendal pruritus, and carbuncle skin ulcer swells.Select Mel to be that flat, enter lung, spleen, large intestine channel, have invigorating middle warmer, moisturize, pain relieving, the function of removing toxic substances, controls xeropulmonary cough, dryness of the intestine constipation, gastralgia, nasal sinusitis, aphtha, the burning hot wound of soup because its nature and flavor are sweet, separate Aconitum Carmichaeli.Select Testa sojae atricolor to be because its nature and flavor are micro-sweet, cool, have the function of the dispelling wind that nourishes blood, control deficiency of YIN dysphoria with smothery sensation, night sweat, dizzy, headache.Select Herba Sedi Sarmentosi to be because its property slightly sweet flavor, cool, have heat clearing away, detumescence, the function of removing toxic substances, controls laryngopharynx swelling and pain, hepatitis, pyretic stranguria, carbuncle, burn due to hot liquid or fire, Serpentis, insect bite wound.Herba Hyperici Japonici is selected to be because its nature and flavor are bitter, pungent, flat, return liver, spleen channel, have eliminating damp-heat, the function of dissipating blood stasis for subsidence of swelling, for acute hepatitis, chronic hepatitis, furuncle carbuncle.Select Rhizoma Paridis to be because its nature and flavor toil, cold, poisonous, enter the heart, Liver Channel, have heat-clearing and toxic substances removing, antiasthmatic-antitussive, the function of the arresting convulsion that relieves dizziness, high fever, infantile convulsions, epilepsy, etc., controls carbuncle, furuncle, scrofula, sore throat, chronic tracheitis, and infantile convulsion is twitched, snake bite and insect sting.Select Fructus Ligustri Lucidi to be because its property bitter but sweet flavor, flat, enter liver, kidney channel, have invigorating the liver and kidney, the function of strong waist knee joint, controls yin asthenia generating intrinsic heat, dizzy, order flower tinnitus, soreness of the waist and knees, early whitening of beard and hair.Herba Artemisiae Scopariae is selected to be because its nature and flavor toil, cool, enter liver, spleen, urinary bladder channel, have the function of clearing away heat-damp and promoting diuresis, control jaundice due to damp-heat, dysuria, pruritus due to wind pathogen skin ulcer scabies.Select Semen Alpiniae Katsumadai to be that temperature, enters spleen, stomach warp, have warming middle-JIAO, cold relieving, circulation of qi promoting, the function of dampness, control trusted subordinate's cold type of pain, feeling of fullness dyspepsia, dysphagia and regurgitation because its nature and flavor are pungent, cold-damp is vomited and diarrhoea, and phlegm retention is gathered.Oryza glutinosa is selected to be that temperature, enters spleen, stomach, lung meridian, have the function of invigorating the spleen and replenishing QI, control frequent micturition of quenching one's thirst, spontaneous perspiration, just let out because its nature and flavor are sweet.Rhizoma Picrorhizae is selected to be because its nature and flavor are bitter, cold, enter liver, stomach, large intestine channel, have heat clearing away, removing heat from blood, the function of dampness, control infantile malnutrition ， Jing Epilepsy, dysentery, consumptive fever hectic fever due to YIN-deficiency, spontaneous perspiration, night sweat, spit blood, epistaxis, acute catarrhal conjunctivitis, hemorrhoid complicated by anal fistula, skin infection.Herba Phyllanthi Urinariae is selected to be that cool, enter liver, lung two warp, have calming liver and clearing heat, the function of promoting diuresis to remove toxic substance, controls enteritis, dysentery, infectious hepatitis, oedema due to nephritis, urinary tract infection, infantile malnutrition, acute catarrhal conjunctivitis corneal nebula, aphtha head sore, innominate toxic swelling because its nature and flavor sweetness and bitterness.Flos Osmanthi Fragrantis is selected to be that temperature, has and reduce phlegm, the function of dissipating blood stasis, control phlegm retention and breath with cough, hemorrhoidal hamorrhage dysentery, hernia abdominal mass because its nature and flavor are pungent, toothache, halitosis.Select Radix Cynanchi Amplexicaulis to be because its property mildly bitter flavor, flat, nontoxic, have heat clearing away, wind-damp dispelling, the function of subduing swelling and detoxicating, controls acute gastroenteritis, acute hepatitis, rheumatalgia, and migraine is had blood in stool, carbuncle, eczema.Select Fel Sus domestica to be because its nature and flavor are bitter, cold, enter liver, gallbladder, lung, large intestine channel, have heat clearing away, moisturize, the function of removing toxic substances, control dry thirsty, the constipation of calentura interior-heat, jaundice, pertussis, asthma, has loose bowels, dysentery, conjunctival congestion, sore throat, Ting ear, carbuncle furuncle.Select Radix Codonopsis to be because its nature and flavor are sweet, flat, start with, meridian of Foot-TAI YIN edema caused by disorder of QI, have invigorating the spleen and replenishing QI, the function of promoting the production of body fluid, controls weakness of the spleen and stomach, deficiency of both QI and blood, fatigue and lack of strength, and lack of appetite is thirsty, chronic diarrhea, proctoptosis.

Detailed description of the invention

The drug dose of the present invention's combination is also that inventor draws through groping in a large number to sum up, and the consumption of each component all has good therapeutic effect within the scope of following weight

Ramulus Euonymi 10-20 gram of Talcum 8-15 gram of Endothelium Corneum Gigeriae Galli 10-20 gram

Semen Glycines 15-25 gram of Periostracum Cicadae 8-15 gram of vinegar 15-25 gram

Mel 10-20 gram of Testa sojae atricolor 10-20 gram of Herba Sedi Sarmentosi 5-15 gram

Herba Hyperici Japonici 8-15 gram of Rhizoma Paridis 5-15 gram of Fructus Ligustri Lucidi 5-10 gram

Herba Artemisiae Scopariae 10-20 gram of Semen Alpiniae Katsumadai 5-15 gram of Oryza glutinosa 15-25 gram

Rhizoma Picrorhizae 6-10 gram of Herba Phyllanthi Urinariae 10-20 gram of Flos Osmanthi Fragrantis 8-15 gram

Radix Cynanchi Amplexicaulis 10-15 gram of Fel Sus domestica 8-15 gram of Radix Codonopsis 8-15 gram

Preferable amount is

Ramulus Euonymi 15 grams of Talcums 10 grams of Endothelium Corneum Gigeriae Galli 15 grams

Semen Glycines 20 grams of Periostracum Cicadaes 10 grams of vinegar 20 grams

Mel 15 grams of Testa sojae atricolors 15 grams of Herba Sedi Sarmentosi 10 grams

Herba Hyperici Japonici 10 grams of Rhizoma Paridis 10 grams of Fructus Ligustri Lucidi 8 grams

20 grams, Herba Artemisiae Scopariae 15 grams of Semen Alpiniae Katsumadai 10 grams of Oryza glutinosa

Rhizoma Picrorhizae 6 grams of Herba Phyllanthi Urinariaes 15 grams of Flos Osmanthi Fragrantis 10 grams

Radix Cynanchi Amplexicaulis 12 grams of Fel Sus domestica 10 grams of Radix Codonopsis 10 grams

The preparation method of medicine of the present invention is as follows

One, get the raw materials ready

1, Ramulus Euonymi: pick decontamination, by water saturates, pulls out, cutting, dries;

2, Talcum: get clean Talcum, break into fragment;

3, Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

4, Semen Glycines: pick clean impurity, dry;

5, Periostracum Cicadae: pick decontamination, cleans and dries;

6, vinegar: extract according to quantity;

7, Mel: get pure Mel, temper with slow fire, filters skimming;

8, Testa sojae atricolor: get Semen sojae atricolor and be soaked in water, after it germinates, rubs lower seed coat with the hands, dries;

9, Herba Sedi Sarmentosi: pick clean impurity, cutting, dry;

10, Herba Hyperici Japonici: removing impurity, cleans, slightly dries in the air, cutting, dry;

11, Rhizoma Paridis: autumn excavates, removing fibrous root, cleaning, drying;

12, Fructus Ligustri Lucidi: pick decontamination, cleans, dries;

13, Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;

14, Semen Alpiniae Katsumadai: pick clean impurity, shell and get core, the used time smashs to pieces;

15, Oryza glutinosa: pick clean impurity, dry;

16, Rhizoma Picrorhizae: pick decontamination, wash in a pan clean with clear water, pick up and run through, section is dried;

17, Herba Phyllanthi Urinariae: gather between spring and autumn, dries;

18, Flos Osmanthi Fragrantis: gather when the 9-10 month blooms, dry in the shade, pick decontamination, airtight storage;

19, Radix Cynanchi Amplexicaulis: pick decontamination, cutting, dries;

20, Fel Sus domestica: fresh Fel Sus domestica is hung up and dries, or when half-dried, flatten slightly, then drying;

21, Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry.

Two, prepare

1, the Ramulus Euonymi of described weight, Talcum (loading cloth bag), Endothelium Corneum Gigeriae Galli, Semen Glycines, Periostracum Cicadae, vinegar, Mel, Testa sojae atricolor, Herba Sedi Sarmentosi, Herba Hyperici Japonici, Rhizoma Paridis, Fructus Ligustri Lucidi, Herba Artemisiae Scopariae, Semen Alpiniae Katsumadai, Oryza glutinosa, Rhizoma Picrorhizae, Herba Phyllanthi Urinariae, Flos Osmanthi Fragrantis, Radix Cynanchi Amplexicaulis, Fel Sus domestica, Radix Codonopsis medicine are decocted with water twice, add water 6 times amount for the first time, soak after 100 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container.

2, add water medicinal residues after first time filtration 4 times amount, decocts boiling, then within 30 minutes, namely obtain second time decoction liquor with slow fire boiling.

3, by twice decoction liquor mixing, 3 doses are divided into take.

Medicine of the present invention has invigorating the liver and kidney, strong waist knee joint, invigorating the spleen and replenishing QI, calming liver and clearing heat, and the function of promoting diuresis to remove toxic substance, is used for the treatment of chronic persistent hepatitis, short treating period, instant effect, has no side effect.

Detailed description of the invention

Set forth the beneficial effect of medicine of the present invention further below by way of test example, these test examples include animal toxicity test report and the clinical observation material of medicine of the present invention.

The animal toxicity test report of [test example 1] medicine of the present invention

Get rabbit 30, male and female dual-purpose, body weight 2.0-2.4kg, divide two groups, often organize 15, wherein one group is overdose test group, and another group is normal amount test group.Super quantity group is 20ml/kg, and normal amount is 10ml/kg, and administering mode is administration by gavage administration, every day 2 times, serve on 7 days, observes administration reaction every day, and result shows that two groups of rabbit are movable, diet is normal, and medicine is without bad toxic and side effects.

The observations of [test example 2] Drug therapy chronic persistent hepatitis of the present invention

1, physical data

Accept chronic persistent hepatitis patient totally 195 examples for medical treatment.

2, diagnostic criteria

Clinical cardinal symptom is bitter taste in the mouth and dry throat, pain in the hypochondrium, insomnia and dreamful sleep, fatigue and weak, and these symptoms are the amount doesn't matter, with liver function injury degree often without comformity relation.Physical examination liver has silght enlargement or little, general without splenomegaly.The course of disease occurs without jaundice through general, and it is main that liver function test raises mainly with individual event glutamate pyruvate transaminase, occurs slight Proteometabolism dysfunction, and be positive, though the course of disease is passed through longer, stable disease, not easily develops into liver cirrhosis more.

3, Therapeutic Method

Select above-mentioned medicament, take to patient, each serving with 1 dose, every day is early, middle and late respectively takes 1 time, within 15 days, is a course for the treatment of, takes 4 courses for the treatment of continuously.

4, efficacy assessment standard

Effective: chronic persistent hepatitis transference cure, observe half a year without bounce-back person;

Take a turn for the better: chronic persistent hepatitis symptom is obviously improved, and body constitution progressively strengthens;

Invalid: chronic persistent hepatitis symptom, without change, does not reach improvement standard person.

5, therapeutic outcome (seeing the following form)

In above-mentioned treatment, by Drug therapy chronic persistent hepatitis patient 195 example of the present invention, effective 184 examples of result, obvious effective rate is 94.36%, and take a turn for the better 8 examples, and improvement rate is 4.1%, and invalid 3 examples, total effective rate is 98.46%.

Claims (3)

1. treat a medicine for chronic persistent hepatitis, it is characterized in that: it is made up of the crude drug in following weight range:

Ramulus Euonymi 10-20 gram of Talcum 8-15 gram of Endothelium Corneum Gigeriae Galli 10-20 gram

Semen Glycines 15-25 gram of Periostracum Cicadae 8-15 gram of vinegar 15-25 gram

Mel 10-20 gram of Testa sojae atricolor 10-20 gram of Herba Sedi Sarmentosi 5-15 gram

Herba Hyperici Japonici 8-15 gram of Rhizoma Paridis 5-15 gram of Fructus Ligustri Lucidi 5-10 gram

Herba Artemisiae Scopariae 10-20 gram of Semen Alpiniae Katsumadai 5-15 gram of Oryza glutinosa 15-25 gram

Rhizoma Picrorhizae 6-10 gram of Herba Phyllanthi Urinariae 10-20 gram of Flos Osmanthi Fragrantis 8-15 gram

Radix Cynanchi Amplexicaulis 10-15 gram of Fel Sus domestica 8-15 gram of Radix Codonopsis 8-15 gram.

2. medicine according to claim 1, wherein the consumption of each crude drug is:

Ramulus Euonymi 15 grams of Talcums 10 grams of Endothelium Corneum Gigeriae Galli 15 grams

Semen Glycines 20 grams of Periostracum Cicadaes 10 grams of vinegar 20 grams

Mel 15 grams of Testa sojae atricolors 15 grams of Herba Sedi Sarmentosi 10 grams

Herba Hyperici Japonici 10 grams of Rhizoma Paridis 10 grams of Fructus Ligustri Lucidi 8 grams

20 grams, Herba Artemisiae Scopariae 15 grams of Semen Alpiniae Katsumadai 10 grams of Oryza glutinosa

Rhizoma Picrorhizae 6 grams of Herba Phyllanthi Urinariaes 15 grams of Flos Osmanthi Fragrantis 10 grams

Radix Cynanchi Amplexicaulis 12 grams of Fel Sus domestica 10 grams of Radix Codonopsis 10 grams.

3. the preparation method of medicine according to claim 1 or 2, is characterized in that: it comprises the following steps:

(1) get the raw materials ready

(1) Ramulus Euonymi: pick decontamination, by water saturates, pulls out, cutting, dries;

(2) Talcum: get clean Talcum, break into fragment;

(3) Endothelium Corneum Gigeriae Galli: pick decontamination, rinses and dries;

(4) Semen Glycines: pick clean impurity, dry;

(5) Periostracum Cicadae: pick decontamination, cleans and dries;

(6) vinegar: extract according to quantity;

(7) Mel: get pure Mel, temper with slow fire, filters skimming;

(8) Testa sojae atricolor: get Semen sojae atricolor and be soaked in water, after it germinates, rubs lower seed coat with the hands, dries;

(9) Herba Sedi Sarmentosi: pick clean impurity, cutting, dry;

(10) Herba Hyperici Japonici: removing impurity, cleans, slightly dries in the air, cutting, dry;

(11) Rhizoma Paridis: autumn excavates, removing fibrous root, cleaning, drying;

(12) Fructus Ligustri Lucidi: pick decontamination, cleans, dries;

(13) Herba Artemisiae Scopariae: sieve, picks decontamination, and removing undesirable root, pulverizes, remove spare after sieve;

(14) Semen Alpiniae Katsumadai: pick clean impurity, shell and get core, the used time smashs to pieces;

(15) Oryza glutinosa: pick clean impurity, dry;

(16) Rhizoma Picrorhizae: pick decontamination, wash in a pan clean with clear water, pick up and run through, section is dried;

(17) Herba Phyllanthi Urinariae: gather between spring and autumn, dries;

(18) Flos Osmanthi Fragrantis: gather when the 9-10 month blooms, dry in the shade, pick decontamination, airtight storage;

(19) Radix Cynanchi Amplexicaulis: pick decontamination, cutting, dries;

(20) Fel Sus domestica: fresh Fel Sus domestica is hung up and dries, or when half-dried, flatten slightly, then drying;

(21) Radix Codonopsis: run through reed after cleaning silt, section or cutting, dry;

(2) prepare

(1) Ramulus Euonymi of described weight, Talcum, Endothelium Corneum Gigeriae Galli, Semen Glycines, Periostracum Cicadae, vinegar, Mel, Testa sojae atricolor, Herba Sedi Sarmentosi, Herba Hyperici Japonici, Rhizoma Paridis, Fructus Ligustri Lucidi, Herba Artemisiae Scopariae, Semen Alpiniae Katsumadai, Oryza glutinosa, Rhizoma Picrorhizae, Herba Phyllanthi Urinariae, Flos Osmanthi Fragrantis, Radix Cynanchi Amplexicaulis, Fel Sus domestica, Radix Codonopsis are decocted with water twice, wherein Talcum loads cloth bag, add water 6 times amount for the first time, soak after 100 minutes, intense fire decocts boiling 10 minutes, use slow fire boiling again 30 minutes, filter first time decoction liquor, first time decoction liquor is poured in container;

(2) add water the medicinal residues after first time filtration 4 times amount, decocts boiling, then within 30 minutes, namely obtain second time decoction liquor with slow fire boiling;

(3) by twice decoction liquor mixing, 3 doses are divided into take.