CN104435710A - Traditional Chinese medicine dispersible tablet capable of soothing liver and strengthening spleen, and preparation method of dispersible tablet - Google Patents
Traditional Chinese medicine dispersible tablet capable of soothing liver and strengthening spleen, and preparation method of dispersible tablet Download PDFInfo
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Abstract
The invention discloses a traditional Chinese medicine dispersible tablet capable of soothing a liver and strengthening a spleen, and a preparation method of the dispersible tablet. The dispersible tablet is prepared from a traditional Chinese medicine extract, a filler, an internal disintegrating agent, an external disintegrating agent, a corrigent, a wetting agent and a lubricant. The dispersible tablet has effects of clearing away heat and toxic materials, soothing the liver and strengthening the spleen, is used for patients with acute hepatitis, chronic hepatitis or early hepatocirrhosis, is good in solubility and dispersity, high in dissolution, good in bioavailability, quick in in-vivo distribution, stable in quality, good in taste and convenient to take, can be swallowed, chewed, sucked or taken after dispersion with water, is more suitable for the old people and patients with difficult swallowing, and has the advantages of good medicine stability, convenience in packaging, transport and storage and the like; and the preparation method of the dispersible tablet is simple and practicable, and is applicable to industrial production.
Description
Technical field
the invention belongs to pharmaceutical technology sectors, be specifically related to a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine and preparation method thereof.
Background technology
viral hepatitis is a kind of infectious disease based on hepatic lesions caused by multiple hepatitis virus.It is a kind of infectious disease of common, multiple, serious harm people life and health.Wherein endanger maximum with second, hepatitis C.Clinically with loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak for main manifestations.Some patients can have jaundice heating and hepatomegaly with liver function injury.Some patient can chronicity, and even develop into liver cirrhosis, minority can develop into hepatocarcinoma.
chinese medicine is anxious, chronic hepatitis has its original characteristic, obviously can improve clinical symptoms and the sign of patient, research in recent years shows, collaborative treatment of Chinese and western medicines acute hepatitis is adopted all obviously to be better than simple western medicine treatment, for urgency, slow virus hepatitis, suppressing the effect of virus replication therefore adjusting immunization therapy is an important directions, make full use of differential diagnosis in tcm to treat, reach depressed liver-energy dispersing and QI regulating, spleen invigorating and in, promoting blood circulation and detoxication effect, treatment by Chinese herbs, it is at antiviral, enzyme falls in jaundice eliminating, alleviate symptom of digestive tract, improve the aspects such as the sign of patient, all there is positive effect, Most patients is made all to obtain good therapeutic effect.
at present, mostly product on market is to make by traditional handicraft, traditional handicraft often adopts various crude drug to be ground into fine powder (more than 80 orders), take after mixing, and this traditional handicraft occupies sizable ratio at Chinese medicine pill, powder in solid kind preparation, traditional process technology makes its drug particle size many at 125 ~ 180 μm, is unfavorable for the abundant absorption of effective ingredient, and it is high to have production cost, utilization ratio of drug generally waits not enough.
Summary of the invention
the object of this invention is to provide a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine and preparation method thereof of a kind of heat-clearing and toxic substances removing, soothing liver and strengthening spleen.
in order to realize object of the present invention, the present invention is achieved by the following technical solutions: a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine, it is characterized in that: be made up of following raw materials according: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 80%, in disintegrating agent 5 ~ 50%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 20%, lubricant 0.05 ~ 20%; Described Chinese medicine extract comprises following raw material: be by ratio of weight and the number of copies: Radix Bupleuri 50-70 part, Rhizoma Polygoni Cuspidati 50-70 part, Cortex Phellodendri 30-50 part, Fructus Schisandrae Chinensis 90-110 part, Radix Astragali 50-70 part, Poria 50-70 part, Rhizoma Polygonati 50-70 part, Radix Isatidis 90-110 part, Fructus Aurantii 50-60 part, Radix Salviae Miltiorrhizae 50-70 part, Fructus Gardeniae 50-70 part, Rhizoma Atractylodis Macrocephalae (parched) 30-50 part, Radix Gentianae 50-70 part.
the optimum weight portion rate of described Chinese medicine extract Raw is: Radix Bupleuri 60 parts, Rhizoma Polygoni Cuspidati 60 parts, Cortex Phellodendri 40 parts, Fructus Schisandrae Chinensis 100 parts, the Radix Astragali 60 parts, 60 parts, Poria, Rhizoma Polygonati 60 parts, Radix Isatidis 100 parts, Fructus Aurantii 40 parts, Radix Salviae Miltiorrhizae 60 parts, Fructus Gardeniae 60 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, Radix Gentianae 60 parts.
described Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 80 parts, in disintegrating agent 5 ~ 50 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 20 part, lubricant 0.05 ~ 20 part.
described Chinese medicine extract 40 parts, filler 30 parts, in disintegrating agent 25 parts, additional disintegrating agent 12 parts, correctives 8 parts, wetting agent 5 parts, lubricant 5 parts.
described filler can be the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; The mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is aspartame, steviosin, citric acid, orange flavor or the mixing of one or more wherein; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by ratio of weight and the number of copies, choose the Radix Bupleuri of high-quality, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Fructus Schisandrae Chinensis, the Radix Astragali, Poria, Rhizoma Polygonati, Radix Isatidis, Fructus Aurantii, Radix Salviae Miltiorrhizae, Fructus Gardeniae, Rhizoma Atractylodis Macrocephalae (parched), Radix Gentianae raw material, clean and remove impurity;
step 2: extract: by ratio of weight and the number of copies, by above-mentioned Chinese medicine, decoct with water secondary, 7 times amount soak by water 1.5 hours for the first time, second time 7 times amount soak by water 1.5 hours, merges twice decocting liquid, filtering medicinal residues and impurity, 90 ~ 95 DEG C time, be concentrated into relative density 1.1-1.3 by filtrate, then be chilled to room temperature, the ethanol adding equivalent makes it precipitation, extracts supernatant, by supernatant at temperature 60-65 DEG C, be concentrated into the clear paste that relative density is about 1.1-1.3, finally at 70 DEG C of drying under reduced pressure, obtain extract;
step 3, preparation: by ratio of weight and the number of copies, extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant evenly, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
in said medicine: Radix Bupleuri reconciling superficies and interior, soothing the liver, yang invigorating.Control alternate attack of chill and fever, fullness in the chest and hypochondriac pain, bitter taste is deaf, headache and dizziness, malaria, lower sharp proctoptosis, menoxenia, uterine prolapse.Rhizoma Polygoni Cuspidati dispels the wind, dampness removing, and removing blood stasis with potent drugs stimulates the menstrual flow.Dispelling the wind and dampness pathogens bones and muscles pain, jaundice due to damp-heat, stranguria with turbid discharge leukorrhagia, women's amenorrhea, lochiostasis, lump in the abdomen, anal fistula hematochezia.Injury from falling down, scalds, malignant boil tinea disease.Arrhythmia and anti-cardiac muscle are lost blood blood circulation promoting and blood stasis dispelling.Cortex Phellodendri heat clearing away.Dampness, pathogenic fire purging, removing toxic substances.Control hematodiarrhoea, have loose bowels, quench one's thirst, jaundice ， flaccidity of feet with lamenness, nocturnal emission, stranguria with turbid discharge, hemorrhoid, have blood in stool, also under leucorrhea, and hectic fever due to YIN-deficiency consumptive fever, conjunctival congestion and swelling pain, aphtha of the mouth and tongue, sore swollen toxin.Fructus Schisandrae Chinensis is astringed the lung, nourishing kidney, promotes the production of body fluid, and receives antiperspirant, arresting seminal emission.Control the deficiency of the lung to breath with cough, xerostomia is done thirsty, spontaneous perspiration, night sweat, impairment caused by overstrain weakness and emaciation, emission, chronic diarrhea chronic dysentery.Radix Astragali invigorating QI to consolidate the body surface resistance, expelling pus and toxin by strengthening QI, diuresis, granulation promoting., chronic diarrhea proctoptosis, spontaneous perspiration, edema weak for the deficiency of vital energy, sub-official prolapsus, chronic nephritis proteinuria, diabetes, open sore part disunion of a specified duration.Poria eliminating dampness and diuresis, strengthening the spleen stomach function regulating, mind tranquilizing and the heart calming.Control dysuria, edema distension, phlegm retention cough with dyspnea, the sound of vomiting of vomitting, has loose bowels, seminal emission, stranguria with turbid discharge, and palpitation with fear is forgetful.Rhizoma Polygonati invigorating the spleen and replenishing QI, profit cardiopulmonary, bone and muscle strengthening.Control deficient cold and heat, pulmonary tuberculosis hemoptysis, after being ill the empty lack of appetite of body, muscles and bones is weak, rheumatalgia, wind favus disease.Radix Isatidis heat clearing away, removing toxic substances, removing heat from blood.Control influenza, epidemic encephalitis, encephalitis b, pneumonia, erysipelas, pyretic toxicity sends out speckle, and coma tells nosebleed, pharyngeal swelling, mumps, acute catarrhal conjunctivitis, skin ulcer rash, and crimson tongue is purple dark, sore throat, scarlet fever, major part pestilence, carbuncle; Epidemic encephalitis type B, acute, chronic hepatitis, mumps, osteomyelitis can be prevented and treated.Fructus Aurantii dispelling the stagnated QI, row expectorant, removing food stagnancy.Control chest and diaphragm expectorant stagnant, the feeling of stuffiness in chest, coerce swollen, food stagnation, eructation, vomiting, heavy after dysentery, proctoptosis, uterine prolapse.Radix Salviae Miltiorrhizae blood circulation promoting and blood stasis dispelling, calming heart and tranquilizing mind, evacuation of pus, pain relieving.Control angina pectoris, menoxenia, dysmenorrhea, amenorrhea, metrorrhagia leukorrhagia ， mass in the abdomen, gathers, abdominal pain due to blood stasis, arthralgia, palpitation with fear sleeplessness, malignant boil toxic swelling.Fructus Gardeniae heat clearing away, pathogenic fire purging, removing heat from blood.Control calentura restlessness of asrhenia type and insomnia, jaundice, gonorrhea, quench one's thirst, conjunctival congestion, pharyngalgia, spit blood, epistaxis, dysentery, hematuria, pathopyretic ulcer, sprains and swells and ache.Rhizoma Atractylodis Macrocephalae (parched) invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, frequent fetal movement.Longdanxiegan gallbladder excess-fire, except damp-heat in lower-JIAO.Treating the liver is through intenseness of heat, and infantile convulsion is manic, encephalitis B, and headache, conjunctival congestion, pharyngalgia, jaundice, hematodiarrhoea, carbuncle skin infection, scrotum swells and ache, pudendum pruritus due to damp pathogen.For damp and hot yellow cellulitis, swelling of the vulva pudendal pruritus, leukorrhagia, eczema pruritus, deafness, hypochondriac pain, bitter taste, convulsion with spasms.
beneficial effect of the present invention: dispersible tablet of the present invention, has heat-clearing and toxic substances removing, effect of soothing liver and strengthening spleen, for acute hepatitis, chronic hepatitis, the patient of early stage liver cirrhosis, its dissolubility, favorable dispersibility, dissolution is high, bioavailability is good, and distribution in vivo is rapid, steady quality, mouthfeel is good, taking convenience, can swallow, chew, containing sucking or taking with after aqueous dispersion, be more suitable for old man and the patient of difficulty of swallowing, there is medicine stability good, packaging, transport, the advantages such as storage is convenient, its preparation method is simple, is applicable to commercial production.
the present invention is through two groups of clinical verifications, and wherein one group is that treatment group eats the present invention, eats the present invention every day once, within 15 days, be a course for the treatment of, another group matched group uses Rhizoma Saururi (Herba Saururi) Ganyan Granule, every group selection outpatient 203 example, wherein man 140 example, female 63 example, max age 75 years old, minimal ages 35 years old, every day uses once, within 15 days, be a course for the treatment of, clinical manifestation be loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak, table one is for taking the contrasting data after the course for the treatment of:
table 1 is taken front and back and is compared (unit: people) two groups of courses for the treatment of
there were significant differences for treatment group and matched group, thus can find out that the present invention's application clinically has significant curative effect.
process characteristic of the present invention: 1, select raw material science, production technology is advanced, and its product is conveniently deposited and used; 2, product Chinese medicine composition is easily absorbed by the body; 3, raw material sources are extensive, add process line short, the easy processing and manufacturing of product.
detailed description of the invention:
embodiment 1
a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine, it is characterized in that: be made up of following raw materials according: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 80%, in disintegrating agent 5 ~ 50%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 20%, lubricant 0.05 ~ 20%; Described Chinese medicine extract comprises following raw material: be by ratio of weight and the number of copies: Radix Bupleuri 50-70 part, Rhizoma Polygoni Cuspidati 50-70 part, Cortex Phellodendri 30-50 part, Fructus Schisandrae Chinensis 90-110 part, Radix Astragali 50-70 part, Poria 50-70 part, Rhizoma Polygonati 50-70 part, Radix Isatidis 90-110 part, Fructus Aurantii 50-60 part, Radix Salviae Miltiorrhizae 50-70 part, Fructus Gardeniae 50-70 part, Rhizoma Atractylodis Macrocephalae (parched) 30-50 part, Radix Gentianae 50-70 part.
the optimum weight portion rate of described Chinese medicine extract Raw is: Radix Bupleuri 60 parts, Rhizoma Polygoni Cuspidati 60 parts, Cortex Phellodendri 40 parts, Fructus Schisandrae Chinensis 100 parts, the Radix Astragali 60 parts, 60 parts, Poria, Rhizoma Polygonati 60 parts, Radix Isatidis 100 parts, Fructus Aurantii 40 parts, Radix Salviae Miltiorrhizae 60 parts, Fructus Gardeniae 60 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, Radix Gentianae 60 parts.
described Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 80 parts, in disintegrating agent 5 ~ 50 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 20 part, lubricant 0.05 ~ 20 part.
described Chinese medicine extract 40 parts, filler 30 parts, in disintegrating agent 25 parts, additional disintegrating agent 12 parts, correctives 8 parts, wetting agent 5 parts, lubricant 5 parts.
described filler can be the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; The mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is aspartame, steviosin, citric acid, orange flavor or the mixing of one or more wherein; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
the concrete steps of its preparation method are:
step 1, to get the raw materials ready: by ratio of weight and the number of copies, choose the Radix Bupleuri of high-quality, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Fructus Schisandrae Chinensis, the Radix Astragali, Poria, Rhizoma Polygonati, Radix Isatidis, Fructus Aurantii, Radix Salviae Miltiorrhizae, Fructus Gardeniae, Rhizoma Atractylodis Macrocephalae (parched), Radix Gentianae raw material, clean and remove impurity;
step 2: extract: by ratio of weight and the number of copies, by above-mentioned Chinese medicine, decoct with water secondary, 7 times amount soak by water 1.5 hours for the first time, second time 7 times amount soak by water 1.5 hours, merges twice decocting liquid, filtering medicinal residues and impurity, 90 ~ 95 DEG C time, be concentrated into relative density 1.1-1.3 by filtrate, then be chilled to room temperature, the ethanol adding equivalent makes it precipitation, extracts supernatant, by supernatant at temperature 60-65 DEG C, be concentrated into the clear paste that relative density is about 1.1-1.3, finally at 70 DEG C of drying under reduced pressure, obtain extract;
step 3, preparation: by ratio of weight and the number of copies, extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant evenly, with tabletting machine, make tablet;
step 4, packaging: according to tablet format, class wrapping, makes finished product.
Claims (6)
1. a soothing liver and strengthening spleen dispersible tablets of Chinese medicine, it is characterized in that: be made up of following raw materials according: by Chinese medicine extract, filler, in make with disintegrating agent, additional disintegrating agent, correctives, wetting agent, lubricant, percentage ratio wherein shared by various raw material is, Chinese medicine extract 10 ~ 50%, filler 10 ~ 80%, in disintegrating agent 5 ~ 50%, additional disintegrating agent 5 ~ 15%, correctives 0.1 ~ 10%, wetting agent 0.1 ~ 20%, lubricant 0.05 ~ 20%; Described Chinese medicine extract comprises following raw material: be by ratio of weight and the number of copies: Radix Bupleuri 50-70 part, Rhizoma Polygoni Cuspidati 50-70 part, Cortex Phellodendri 30-50 part, Fructus Schisandrae Chinensis 90-110 part, Radix Astragali 50-70 part, Poria 50-70 part, Rhizoma Polygonati 50-70 part, Radix Isatidis 90-110 part, Fructus Aurantii 50-60 part, Radix Salviae Miltiorrhizae 50-70 part, Fructus Gardeniae 50-70 part, Rhizoma Atractylodis Macrocephalae (parched) 30-50 part, Radix Gentianae 50-70 part.
2. a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine according to claim 1, is characterized in that: the optimum weight portion rate of described Chinese medicine extract Raw is: Radix Bupleuri 60 parts, Rhizoma Polygoni Cuspidati 60 parts, Cortex Phellodendri 40 parts, Fructus Schisandrae Chinensis 100 parts, the Radix Astragali 60 parts, 60 parts, Poria, Rhizoma Polygonati 60 parts, Radix Isatidis 100 parts, Fructus Aurantii 40 parts, Radix Salviae Miltiorrhizae 60 parts, Fructus Gardeniae 60 parts, Rhizoma Atractylodis Macrocephalae (parched) 40 parts, Radix Gentianae 60 parts.
3. a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine according to claim 1, is characterized in that: described Chinese medicine extract 10 ~ 50 parts, filler 10 ~ 80 parts, in disintegrating agent 5 ~ 50 parts, additional disintegrating agent 5 ~ 15 parts, correctives 0.1 ~ 10 part, wetting agent 0.1 ~ 20 part, lubricant 0.05 ~ 20 part.
4. a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine according to claim 1, is characterized in that: described Chinese medicine extract 40 parts, filler 30 parts, in disintegrating agent 25 parts, additional disintegrating agent 12 parts, correctives 8 parts, wetting agent 5 parts, lubricant 5 parts.
5. a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine according to claim 1, is characterized in that: described filler can be the mixing of pregelatinized Starch, mannitol, microcrystalline Cellulose, sucrose, lactose, sodium chloride, calcium sulfate wherein one or more; The mixing of low-substituted hydroxypropyl cellulose, carboxymethylstach sodium, cross-linking sodium carboxymethyl cellulose, polyvinylpolypyrrolidone wherein one or more with disintegrating agent or additional disintegrating agent in described; Described correctives is aspartame, steviosin, citric acid, orange flavor or the mixing of one or more wherein; Described wetting agent is one or both the mixing in water, alcoholic solution; Described lubricant is the mixing of magnesium stearate, sodium lauryl sulphate, silicon dioxide, Pulvis Talci wherein one or more.
6. the preparation method of a kind of soothing liver and strengthening spleen dispersible tablets of Chinese medicine according to claim 1-5, is characterized in that: the concrete steps of its preparation method are:
Step 1, to get the raw materials ready: by ratio of weight and the number of copies, choose the Radix Bupleuri of high-quality, Rhizoma Polygoni Cuspidati, Cortex Phellodendri, Fructus Schisandrae Chinensis, the Radix Astragali, Poria, Rhizoma Polygonati, Radix Isatidis, Fructus Aurantii, Radix Salviae Miltiorrhizae, Fructus Gardeniae, Rhizoma Atractylodis Macrocephalae (parched), Radix Gentianae raw material, clean and remove impurity;
Step 2: extract: by ratio of weight and the number of copies, by above-mentioned Chinese medicine, decoct with water secondary, 7 times amount soak by water 1.5 hours for the first time, second time 7 times amount soak by water 1.5 hours, merges twice decocting liquid, filtering medicinal residues and impurity, 90 ~ 95 DEG C time, be concentrated into relative density 1.1-1.3 by filtrate, then be chilled to room temperature, the ethanol adding equivalent makes it precipitation, extracts supernatant, by supernatant at temperature 60-65 DEG C, be concentrated into the clear paste that relative density is about 1.1-1.3, finally at 70 DEG C of drying under reduced pressure, obtain extract;
Step 3, preparation: by ratio of weight and the number of copies, extract is ground into fine powder, cross 80 mesh sieves, then add filler, in disintegrating agent mix homogeneously, add wetting agent, adopt fluidized bed granulation technology to granulate, after obtained granulate, add additional disintegrating agent, correctives, mix lubricant evenly, with tabletting machine, make tablet;
Step 4, packaging: according to tablet format, class wrapping, makes finished product.
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| CN105381040A (en) * | 2015-11-19 | 2016-03-09 | 哈尔滨圣吉药业股份有限公司 | Dispersible tablets with functions of harmonizing liver and benefiting gallbladder and preparation method thereof |
| CN106728983A (en) * | 2015-11-19 | 2017-05-31 | 哈尔滨圣吉药业股份有限公司 | A kind of fibert strengthening the spleen and stomach electuary and preparation method thereof |
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