CN103721108B - A kind of medicament for the treatment of acute icterohepatitis - Google Patents
A kind of medicament for the treatment of acute icterohepatitis Download PDFInfo
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- CN103721108B CN103721108B CN201410026942.7A CN201410026942A CN103721108B CN 103721108 B CN103721108 B CN 103721108B CN 201410026942 A CN201410026942 A CN 201410026942A CN 103721108 B CN103721108 B CN 103721108B
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Abstract
The present invention relates to a kind of medicament for the treatment of acute icterohepatitis, it is made up by weight of following bulk drugs: the sub-wood of Herba Alternantherae sessilis, Radix seu Herba Poranae Racemosae, Herba Begoniae Yunnanensis, water, Fructus Pruni Tomentosae, Radix Ginseng Rubra, Jasminum floridum Bge., Radix Paeoniae Rubra, Herba Digitariae, Rhizoma Gastrodiae, Herba Moslae Soochowensis, Herba Lycopodii, Elatostema oblohgifolium Fu. (Elatostema bodinier Levl), Fructus Gardeniae, Herba Limnophilae rugosae, Fructus Perillae Frutescentis, Semen Ziziphi Spinosae, Radix seu herba Heteropogonis Contorti and Folium Nelumbinis.The medicament for the treatment of acute icterohepatitis of the present invention amounts to clearing away heat-damp and promoting diuresis, the merit of removing pathogenic heat from blood and toxic substance from the body, and thus clinical efficacy is remarkable, effectively can treat acute icterohepatitis.
Description
Technical field
The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of acute icterohepatitis.
Background technology
Acute icterohepatitis is one of common emergency case of hepatopathy section, and western medical treatment mostly is antiinflammatory, hepatoprotective, vitimin supplement treatment.
Summary of the invention
The object of this invention is to provide a kind of medicament for the treatment of acute icterohepatitis.
In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of acute icterohepatitis, it is made up by weight of following bulk drugs: Herba Alternantherae sessilis 1-20 part, Radix seu Herba Poranae Racemosae 1-20 part, Herba Begoniae Yunnanensis 1-20 part, the sub-wooden 5-25 part of water, Fructus Pruni Tomentosae 1-20 part, Radix Ginseng Rubra 1-10 part, Jasminum floridum Bge. 1-10 part, Radix Paeoniae Rubra 1-10 part, Herba Digitariae 1-10 part, Rhizoma Gastrodiae 1-10 part, Herba Moslae Soochowensis 1-10 part, Herba Lycopodii 1-10 part, Elatostema oblohgifolium Fu. (Elatostema bodinier Levl) 5-15 part, Fructus Gardeniae 5-15 part, Herba Limnophilae rugosae 5-15 part, Fructus Perillae Frutescentis 1-10 part, Semen Ziziphi Spinosae 1-10 part, Radix seu herba Heteropogonis Contorti 1-10 part and Folium Nelumbinis 1-10 part.
Preferably, the medicament for the treatment of acute icterohepatitis of the present invention is made up by weight of following bulk drugs: sub-10 parts, the wood of Herba Alternantherae sessilis 15 parts, Radix seu Herba Poranae Racemosae 12 parts, Herba Begoniae Yunnanensis 12 parts, water, Fructus Pruni Tomentosae 9 parts, Radix Ginseng Rubra 9 parts, Jasminum floridum Bge. 9 parts, Radix Paeoniae Rubra 9 parts, Herba Digitariae 8 parts, 8 parts, Rhizoma Gastrodiae, Herba Moslae Soochowensis 8 parts, Herba Lycopodii 7 parts, Elatostema oblohgifolium Fu. (Elatostema bodinier Levl) 6 parts, Fructus Gardeniae 6 parts, Herba Limnophilae rugosae 6 parts, Fructus Perillae Frutescentis 3 parts, Semen Ziziphi Spinosae 3 parts, Radix seu herba Heteropogonis Contorti 3 parts and 2 parts, Folium Nelumbinis.
More preferably, described medicament can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, capsule or decoction.
In the present compositions, Herba Alternantherae sessilis, Radix seu Herba Poranae Racemosae, Herba Begoniae Yunnanensis, the sub-wood of water are monarch drug; Fructus Pruni Tomentosae, Radix Ginseng Rubra, Jasminum floridum Bge., Radix Paeoniae Rubra, Herba Digitariae, Rhizoma Gastrodiae are ministerial drug; Herba Moslae Soochowensis, Herba Lycopodii, Elatostema oblohgifolium Fu. (Elatostema bodinier Levl), Fructus Gardeniae, Herba Limnophilae rugosae are adjuvant drug; Fructus Perillae Frutescentis, Semen Ziziphi Spinosae, Radix seu herba Heteropogonis Contorti and Folium Nelumbinis are for making medicine, and various ingredient exerts synergism is to produce optimum efficiency.
In order to understand the present invention better, the explanation with reference to some crude drug used in " Chinese medicine voluminous dictionary " second edition (Shanghai science tech publishing house 2005) the present invention sees the following form:
The medicament for the treatment of acute icterohepatitis of the present invention amounts to clearing away heat-damp and promoting diuresis, the merit of removing pathogenic heat from blood and toxic substance from the body, and thus clinical efficacy is remarkable, effectively can treat acute icterohepatitis.
Detailed description of the invention
The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.
Embodiment decoction of the present invention
Get Herba Alternantherae sessilis 15 grams, Radix seu Herba Poranae Racemosae 12 grams, Herba Begoniae Yunnanensis 12 grams, sub-10 grams, the wood of water, Fructus Pruni Tomentosae 9 grams, Radix Ginseng Rubra 9 grams, Jasminum floridum Bge. 9 grams, Radix Paeoniae Rubra 9 grams, Herba Digitariae 8 grams, 8 grams, Rhizoma Gastrodiae, Herba Moslae Soochowensis 8 grams, Herba Lycopodii 7 grams, Elatostema oblohgifolium Fu. (Elatostema bodinier Levl) 6 grams, Fructus Gardeniae 6 grams, Herba Limnophilae rugosae 6 grams, Fructus Perillae Frutescentis 3 grams, Semen Ziziphi Spinosae 3 grams, Radix seu herba Heteropogonis Contorti 3 grams and 2 grams, Folium Nelumbinis, add 15000 milliliters, water, heat 3 hours at 90 DEG C in the flask that condenser is housed, filter, obtain filtering residue and filtrate 1.In filtering residue, add 20000 milliliters, water, heat 6 hours at 70 DEG C in the flask that condenser is housed, filter, obtain filtering residue and filtrate 2.Merging filtrate 1 and filtrate 2, be concentrated into 9000 milliliters, is decoction of the present invention.
Experimental example
Physical data
Select medical acute icterohepatitis 68 example, all meet the viral hepatitis of Chinese Medical Association Xi'an meeting revision diagnostic criteria (Chinese Medical Association. the diagnostic criteria (S) of viral hepatitis. combination of Chinese and Western medicine hepatopathy magazine, 2001,11 (1), 56-60).Wherein, man 34 example, female 34 example; Age 22-65 year, average 41.5 years old; Divide by the course of disease: 1-7 days 42 examples, 8-15 days 26 examples; Lab testing: total bilirubin (TBIL) is in 17.1-34.2 μm o1/L person 14 example, and in 34.3-68.4 μm o1/L person 20 example, in 68.5-136.8 μm o1/L person 24 example, >136.8 μm o1/L person 10 is routine; ALT (alanine aminotransferase) is in 50-99U/L person 12 example, and in 100-199U/L person 20 example, in 200-299U/L person 14 example, >300U/L person 22 is routine.
Above-mentioned patient divided into groups, treatment group and equal 34 examples of matched group, two groups of patients are in sex, age, the course of disease, lab testing etc., and through statistical procedures P>0.05, there was no significant difference, has comparability.
Matched group gives diammonium glycyrrhizinate 150mg, Yinzhihuang Injection 30m1, adds 5 % by weight Glucose Liquid 250ml intravenous drips respectively, 1 day 1 time.Every day 3 times, each oral liver-protecting tablet (Heilongjiang Kuihua Yaoye Co.Ltd Co., Ltd simultaneously, every sheet weighs 0.36 gram) 4 slices, Catergen sheet (Kang Enbei Zhejiang Pharmaceutical Co, every sheet 0.6 gram), vitamin B group 2 (Kang Enbei Zhejiang Pharmaceutical Co, every sheet 0.7 gram).Continuous treatment 1 month.
Decoction obtained in the oral embodiment 1 for the treatment of group is treated, one day three times, oral 100 milliliters at every turn, continuously treatment 1 month.
Observation item
Observe clinical symptoms and sign before and after patient consumes, and detect Serum ALT, TBIL level.
Curative effect determinate standard
With reference to Ministry of Public Health formulate " new Chinese medicine guideline of clinical investigations " (Ministry of Public Health. new Chinese medicine guideline of clinical investigations [S] Beijing: China Medical Science Press, 1993:252) draft.Disappear with symptom and sign, Serum ALT, it is effective that TBIL recovers normally; Obviously improve with symptom and sign, Serum ALT, before TBIL comparatively treats, decline more than 50% is effective; To treat the above symptom and sign of first quarter moon without improvement, Serum ALT, TBIL have no decline or continue to rise to invalid.
Result
Through treatment, the therapeutic outcome of two groups sees the following form:
| Group | Number of cases | Effective | Effectively | Invalid | Total effective rate |
| （%） | |||||
| Treatment group | 34 | 22 | 11 | 1 | 97.06 |
| Matched group | 34 | 10 | 19 | 5 | 85.29 |
Model case
Lee, man, 52 years old, people from Zhou Cheng, Shandong, legs and feet are heavy, feel run-down, inappetence, with the symptom of low grade fever and nausea and vomiting, go to a doctor on October 26th, 2012, blood test suffers from acute icterohepatitisshock, lab testing: total bilirubin (TBIL) is 56.2 μm of o1/L, ALT (alanine aminotransferase) is 156U/L.Decoction obtained in oral embodiment 1 is treated, one day three times, oral 100 milliliters at every turn, continuously treatment 1 month.After treatment, Serum ALT, TBIL recovers normal value, and symptom disappears substantially, follows up a case by regular visits to and does not recur so far again.
Lv, female, 43 years old, people from Zhou Cheng, Shandong, has a fever 38.3 DEG C, weak, inappetence, yellowish urine is as tea, and skin, sclera turn to be yellow, hepatalgia, go to a doctor on March 9th, 2013, blood test suffers from acute icterohepatitisshock, lab testing: total bilirubin (TBIL) is 112.5 μm of o1/L, ALT (alanine aminotransferase) is 183U/L.Decoction obtained in oral embodiment 1 is treated, one day three times, oral 100 milliliters at every turn, continuously treatment 1 month.After treatment, Serum ALT, TBIL recovers normal value, and symptom disappears substantially, follows up a case by regular visits to and does not recur so far again.
Stone, man, 31 years old, people from Zhou Cheng, Shandong, heating, general malaise, weak, right epigastric discomfort.Go to a doctor on January 12nd, 2013, to have a medical check-up discovery skin, yellow sclera, hepatosplenomegaly, hepatalgia, liver function test is abnormal, and blood test suffers from acute icterohepatitisshock, lab testing: total bilirubin (TBIL) is 101.8 μm of o1/L, ALT (alanine aminotransferase) is 166U/L.Decoction obtained in oral embodiment 1 is treated, one day three times, oral 100 milliliters at every turn, continuously treatment 1 month.After treatment, Serum ALT, TBIL recovers normal value, and symptom disappears substantially, follows up a case by regular visits to and does not recur so far again.
Claims (1)
1. treat the medicament of acute icterohepatitis for one kind, it is characterized in that, it is made up by following method of following bulk drugs: get Herba Alternantherae sessilis 15 grams, Radix seu Herba Poranae Racemosae 12 grams, Herba Begoniae Yunnanensis 12 grams, sub-10 grams, the wood of water, Fructus Pruni Tomentosae 9 grams, Radix Ginseng Rubra 9 grams, Jasminum floridum Bge. 9 grams, Radix Paeoniae Rubra 9 grams, Herba Digitariae 8 grams, 8 grams, Rhizoma Gastrodiae, Herba Moslae Soochowensis 8 grams, Herba Lycopodii 7 grams, Elatostema oblohgifolium Fu. (Elatostema bodinier Levl) 6 grams, Fructus Gardeniae 6 grams, Herba Limnophilae rugosae 6 grams, Fructus Perillae Frutescentis 3 grams, Semen Ziziphi Spinosae 3 grams, Radix seu herba Heteropogonis Contorti 3 grams and 2 grams, Folium Nelumbinis, add 15000 milliliters, water, heat 3 hours at 90 DEG C in the flask that condenser is housed, filter, obtain filtering residue and filtrate 1, 20000 milliliters, water is added in described filtering residue, heat 6 hours at 70 DEG C in the flask that condenser is housed, filter, obtain filtering residue and filtrate 2, merge described filtrate 1 and described filtrate 2, be concentrated into 9000 milliliters, obtain.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201410026942.7A CN103721108B (en) | 2014-01-21 | 2014-01-21 | A kind of medicament for the treatment of acute icterohepatitis |
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| CN201410026942.7A CN103721108B (en) | 2014-01-21 | 2014-01-21 | A kind of medicament for the treatment of acute icterohepatitis |
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| CN103721108B true CN103721108B (en) | 2015-09-23 |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113779A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Anti- hepatitis B preparation |
| CN103041301A (en) * | 2012-12-21 | 2013-04-17 | 孙红梅 | Traditional Chinese medicine composition for treating icterohepatitis |
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2014
- 2014-01-21 CN CN201410026942.7A patent/CN103721108B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1113779A (en) * | 1994-06-17 | 1995-12-27 | 殷广全 | Anti- hepatitis B preparation |
| CN103041301A (en) * | 2012-12-21 | 2013-04-17 | 孙红梅 | Traditional Chinese medicine composition for treating icterohepatitis |
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| CN103721108A (en) | 2014-04-16 |
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