CN104435125A - Traditional Chinese medicine composition preparation for treating viral hepatitis - Google Patents
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Abstract
The invention discloses a traditional Chinese medicine composition preparation for treating viral hepatitis. Raw materials of the traditional Chinese medicine composition preparation are composed of the following traditional Chinese medicine in parts by weight: 15-50 parts of root of Cochinchina Cudrania, 10-30 parts of asiatic pennywort herb, 10-30 parts of all-grass of Madras Grangea, 8-20 parts of capillary artemisia, 8-20 parts of agaric, 10-20 parts of Chinese Taxillus Twig, 10-30 parts of root of lobed kudzuvine and 3-8 parts of Liquorice Root. By utilizing the traditional Chinese medicine composition preparation, symptoms of jaundice, anorexia, nausea, epigastric discomfort, hepatic region ache, lacking in strength and the like of a viral hepatitis patient can be obviously improved, resistance of the patient can be also improved, and the traditional Chinese medicine composition preparation has the effects of clearing heat, removing toxicity, disinhibiting dampness and relieving jaundice. The traditional Chinese medicine composition preparation is rigorous in formula, less in medicine, special in efficacy and convenient to take and has good effect on the viral hepatitis.
Description
Technical field
The invention belongs to medicine field, relate to a kind of Chinese medicinal composition preparation for the treatment of viral hepatitis.
Background technology
Viral hepatitis is a kind of infectious disease based on hepatic lesions caused by multiple hepatitis virus, clearly at present mainly contains A type, B-mode, the third type, fourth type and 5 kinds, penta type, is characterized in: route of transmission complicated, popular wide, sickness rate is high.Chinese medicine from entirety in treatment viral hepatitis, is transferred the immunologic function of whole body system, is had good curative effect.The present invention is Traditional Chinese medicine composition formula, starts with, activate hepatocyte cambium from removing toxic substances diuresis, repair Liver immunity function, building up resistance, is suit the remedy to the case according to etiopathogenesis, have no side effect, can symptom management effectively after taking medicine, there is therapeutical effect to viral hepatitis.
(1) Radix Cudraniae is the dry root of Moraceae three-bristle cudrania platymiscium cudrania cochinchinensis Cudrania cochin chinensis (Lour.) Kudo et Masam..[nature and flavor] micro-hardship, flat.[function with cure mainly] heat-clearing and toxic substances removing, expelling wind and removing dampness, eliminating stasis to stop pain.For pulmonary tuberculosis, icterohepatitis, hepatosplenomegaly, taste-blindness rate, rheumatic lumbago and scelalgia; Fracture is controlled in external, traumatic injury.
(2) Herba Centellae is the dry herb of samphire Herba Centellae Centella asiatica (L.) Urb..[nature and flavor with return through] bitter, acrid, cold.Return liver,spleen,kidney warp.[function with cure mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling.For jaundice due to damp-heat, heatstroke is suffered from diarrhoea, stranguria caused by urinary stone stranguria with blood, carbuncle sore tumefacting virus, injury from falling down.
(3) Herba Hyperici Japonici is Hypericaceae hypericum
herba Hyperici Japonicithe dry herb of Hypericum japonicum Thunb..[nature and flavor] sweet, micro-hardship, cool.[function with cure mainly] clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, eliminating stasis to stop pain.For hepatitis, early stage liver cirrhosis, appendicitis, eye conjunctivitis, tonsillitis; Furuncle toxic swelling is controlled in external, herpes zoster, venom, traumatic injury.
(4) Herba Artemisiae Scopariae is the dry aerial parts of feverfew Artemisia scoparia Waldst. et Kit. Artemisia scoparza Waldst.et Kit. or Herba Artemisiae Scopariae Artemisiacapillaris Thunb..[nature and flavor with return through] are bitter, pungent, are slightly cold.Return spleen, stomach, liver, gallbladder meridian.[function with cure mainly] eliminating damp-heat, promoting the function of the gallbladder to alleviate jaundice.For jaundice oliguria, hygropyrexia heat-damp in summer, eczema pruritus.
(5) Polyporus is the dry sclerotia of On Polyporaceae Polyporus Polyporus umbellatus (Pers.) Fries.[meridian distribution of property and flavor] is sweet, light, flat.Return kidney, urinary bladder channel.[function with cure mainly] promoting diuresis to eliminate damp pathogen, for dysuria, edema, has loose bowels, stranguria with turbid discharge, leukorrhagia.
(6) Herba Taxilli is Loranthaceae plant Herba Taxilli Taxillus chinensis (DC.) Danser.Dry stem and branch with leaf.[nature and flavor with return through] bitter, sweet, flat.Return liver, kidney channel.[function with cure mainly] wind-damp dispelling, invigorating the liver and kidney, bone and muscle strengthening, antiabortive unit.For rheumatic arthralgia, soreness of the waist and knees, muscles and bones is unable, and metrorrhagia is through many, and blood leaking in gestation, frequent fetal movement, has a dizzy spell.
(7) Radix Puerariae is the dry root of legume pueraria lobata Pueraria lobata (Willd.) ohwi.[nature and flavor with return through] are sweet, pungent, cool.Return spleen, stomach, lung meridian.[function with cure mainly] expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, alcoholic intoxication.For fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, has loose bowels, dizziness and headache, apoplectic hemiplegia, obstruction of qi in the chest and cardialgia, damage of the spleen and stomach caused by alcoholism.
(8) Radix Glycyrrhizae is the dry root and rhizome of glycyrrhizic legume Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. Glycyrrhizainflata Bat. or Glycyrrhiza glabra L. Glycyrrhiza glabra L..[nature and flavor with return through] are sweet, flat.GUIXIN, lung, spleen, stomach warp.[function with cure mainly] invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Summary of the invention
The object of this invention is to provide a kind of Chinese medicinal composition preparation for the treatment of viral hepatitis, said preparation has heat-clearing and toxic substances removing, dampness removing jaundice eliminating effect, effectively can treat viral hepatitis.
The technical solution adopted in the present invention is as follows:
Treat a Chinese medicinal composition preparation for viral hepatitis, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 15-50 part, Herba Centellae 10-30 part, Herba Hyperici Japonici 10-30 part, Herba Artemisiae Scopariae 8-20 part, Polyporus 8-20 part, Herba Taxilli 10-20 part, Radix Puerariae 10-30 part, Radix Glycyrrhizae 3-8 part;
Its preparation method is:
(1) get above-mentioned Chinese medicinal components respectively, clean, dry;
(2) Chinese medicinal components is taken respectively by above-mentioned weight portion;
(3) split in extraction pot by load weighted Chinese drug-treated group, add 10 times of water gagings, heating extraction 3 times, each 1 hour, filter, merging filtrate, when filtrate is condensed into 60 DEG C, relative density is 1.20-1.30 thick paste, and add appropriate amount of starch, dry, pulverize, get dry extract powder;
(4) add the magnesium stearate of 1% again, mixing, incapsulates, to obtain final product.
The Chinese medicinal composition preparation of the above treatment viral hepatitis, raw material is preferably made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 25-40 part, Herba Centellae 15-25 part, Herba Hyperici Japonici 15-25 part, Herba Artemisiae Scopariae 10-18 part, Polyporus 10-18 part, Herba Taxilli 12-18 part, Radix Puerariae 15-25 part, Radix Glycyrrhizae 4-6 part, and the best is preferably made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 30 parts, Herba Centellae 20 parts, Herba Hyperici Japonici 20 parts, Herba Artemisiae Scopariae 15 parts, Polyporus 15 parts, Herba Taxilli 15 parts, Radix Puerariae 20 parts, 5 parts, Radix Glycyrrhizae.
The Chinese medicine composition of above-described treatment viral hepatitis, pharmaceutically acceptable any dosage form can be prepared into, as: powder, granule (electuary), pill, tablet, capsule, decoction, mixture (comprising oral liquid), syrup etc., as preferably, described dosage form is capsule.
The preparation method science of the above preparation, production technology is simple, and dose is few, conveniently takes, good effect.
The present invention is on the basis of Chinese medicine traditional theory, in conjunction with medication experience among the people, uses modern scientific theory formulated.Radix Cudraniae in side, has heat-clearing and toxic substances removing, expelling wind and removing dampness, effect of eliminating stasis to stop pain, is monarch drug.Herba Centellae has clearing away heat-damp and promoting diuresis, the merit of removing toxic substances and promoting subsidence of swelling; Herba Hyperici Japonici has clearing away heat-damp and promoting diuresis, removing toxic substances and promoting subsidence of swelling, the merit of eliminating stasis to stop pain; Herba Artemisiae Scopariae has eliminating damp-heat, the merit of promoting the function of the gallbladder to alleviate jaundice; Polyporus has the merit of promoting diuresis to eliminate damp pathogen; Be ministerial drug altogether.Herba Taxilli has invigorating the liver and kidney, bone and muscle strengthening effect; Radix Puerariae has expelling pathogenic factors from muscles for reducing heat, promoting the production of body fluid to quench thirst, rash, yang invigorating antidiarrheal, dredge the meridian passage, the merit of alcoholic intoxication; The two is combined into adjuvant drug.Radix Glycyrrhizae has invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the merit of coordinating the actions of various ingredients in a prescription, for making medicine.All medicines share the merit of playing heat-clearing and toxic substances removing, dampness removing jaundice eliminating altogether, obviously can improve patient's jaundice, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the symptom such as weak, the resistance of patient can also be improved.Prescription of the present invention is rigorous, parum drug and centralize the power, and having viral hepatitis has good curative effect.
Detailed description of the invention
Below in conjunction with specific embodiment, the invention will be further described, but do not limit the scope of the invention and range of application:
One, the preparation method of the Chinese medicinal composition preparation of viral hepatitis is treated
1. EXPERIMENTAL DESIGN:
This test 5 embodiments are prepared into capsule respectively, and design parameter refers to table 1.
Table 1 embodiment preparation parameter table
Embodiment | Embodiment 1 | Embodiment 2 | Embodiment 3 | Embodiment 4 | Embodiment 5 |
Radix Cudraniae (kg) | 15 | 25 | 40 | 50 | 30 |
Herba Centellae (kg) | 10 | 15 | 25 | 30 | 20 |
Herba Hyperici Japonici (kg) | 10 | 15 | 25 | 30 | 20 |
Herba Artemisiae Scopariae (kg) | 8 | 10 | 18 | 20 | 15 |
Polyporus (kg) | 8 | 10 | 18 | 20 | 15 |
Herba Taxilli (kg) | 10 | 12 | 18 | 20 | 15 |
Radix Puerariae (kg) | 10 | 15 | 25 | 30 | 20 |
Radix Glycyrrhizae (kg) | 3 | 4 | 6 | 8 | 5 |
2. operating procedure:
(1) get Radix Cudraniae, Herba Centellae, Herba Hyperici Japonici, Herba Artemisiae Scopariae, Polyporus, Herba Taxilli, Radix Puerariae, Radix Glycyrrhizae respectively, clean, dry;
(2) take respectively by table 1 weight portion: Radix Cudraniae, Herba Centellae, Herba Hyperici Japonici, Herba Artemisiae Scopariae, Polyporus, Herba Taxilli, Radix Puerariae, Radix Glycyrrhizae;
(3) split in extraction pot by load weighted Chinese drug-treated group, add 10 times of water gagings, heating extraction 3 times, each 1 hour, filter, merging filtrate, when filtrate is condensed into 60 DEG C, relative density is 1.20-1.30 thick paste, and add appropriate amount of starch, dry, pulverize, get dry extract powder;
(4) add the magnesium stearate of 1% again, mixing, incapsulates, to obtain final product.
Two, clinical practice
1. case selection standard
All cases all meet the viral hepatitis control prece of the tenth the national viral hepatitis control in Xi'an in 2000 and hepatopathy academic conference discussion revision " diagnostic criteria.
(1) clinical symptoms is: jaundice, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak; Liver obviously increases at no distant date, and with tenderness or button pain.
(2) Liver function grade is positive: alanine aminotransferase (ALT) > 80u/L, serum bilirubin > 34 μm of ol/L.
(3) patient did not take any medicine or poisonous substance that can produce jaundice in the recent period, and near over the past half year without injection blood plasma, serum or blood history.
Possess above three, the age is 15-70 year person simultaneously.
2. therapeutic scheme
(1) embodiment group: by above-mentioned embodiment 3 sample prepared, for clinical trial.Oral, one time 3,4 times on the one.The course for the treatment of: medication 1 month.
(2) matched group: the grand granule of sharp liver (commercially available).Oral, once a bag, 3 times on the one.The course for the treatment of: medication 1 month.
3. efficacy assessment standard
(1) fully recover: jaundice disappears, liver recovers normal size, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the main clinic symptoms such as weak disappear; Liver function recovery is normal.
(2) improve: jaundice goes down, liver recovers normal size or stablize constant, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the main clinic symptoms such as weak alleviate; Liver function grade: alanine aminotransferase (ALT): 40u/L < ALT ﹤ 80u/L, 17 μm of ol/L < serum bilirubin ﹤, 34 μm of ol/L.
4. result of the test: the present invention is used for the treatment of and observes 88 routine outpatients.By above-mentioned embodiment 3 sample for preparing and the grand granule of sharp liver, be respectively used to patient: treatment group: 58 examples (man 25 example, female 18 example, 35.8 years old mean age), matched group 30 example (man 13 example, female 17 example, 41.8 years old mean age), the results detailed in Table 2.
Table 2 clinical trial result table
Result shows: adopt the embodiment of the present invention 3 to treat, cure rate is 66%, effective percentage reaches 94%, general effect and matched group are suitable, do not have untoward reaction to occur, use safety, effective, obviously can improve patient's jaundice, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, the symptom such as weak, there is heat-clearing and toxic substances removing, dampness removing jaundice eliminating effect, the resistance of patient can also be improved, favourable prognosis.Be below several model case:
Case 1: multitude's ××, female, 18 years old, readme yellow urine, bitter taste, desire for cold drinks, loss of appetite, feel sick, epigastric discomfort, pain in the hepatic region, weak, see the jaundice of its complexion, hospital's Liver function grade is positive.Take the embodiment of the present invention 3 sample, one time 3,4 times on the one, medication 1 month, above symptom is eliminated, and hospital carries out Liver function grade, and result is normal, recovery from illness.
Case 2: Lu's ××, man, 55 years old, oil, loss of appetite, Nausea and vomiting, abdominal distention, weak, bitter taste, complexion jaundice were detested in readme, and with low grade fever, hospital's Liver function grade is positive.Take the embodiment of the present invention 3 sample, one time 3,4 times on the one, medication 1 month, above symptom is eliminated, and hospital carries out Liver function grade, and result is normal, recovery from illness.
Case 3: Rhizoma Zingiberis Recens ××, man, 40 years old, the decline of readme malaise, appetite, Nausea and vomiting, yellowish urine, detest greasy food, hospital's Liver function grade is positive.Take the embodiment of the present invention 3 sample, one time 3,4 times on the one, after serveing on 5, urine recovers normal, appetite increases, and continue medication 1 month, above symptom is eliminated, and hospital carries out Liver function grade, and result is normal, recovery from illness.
Claims (3)
1. treat the Chinese medicinal composition preparation of viral hepatitis for one kind, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 15-50 part, Herba Centellae 10-30 part, Herba Hyperici Japonici 10-30 part, Herba Artemisiae Scopariae 8-20 part, Polyporus 8-20 part, Herba Taxilli 10-20 part, Radix Puerariae 10-30 part, Radix Glycyrrhizae 3-8 part;
Its preparation method is:
(1) get above-mentioned Chinese medicinal components respectively, clean, dry;
(2) Chinese medicinal components is taken respectively by above-mentioned weight portion;
(3) split in extraction pot by load weighted Chinese drug-treated group, add 10 times of water gagings, heating extraction 3 times, each 1 hour, filter, merging filtrate, when filtrate is condensed into 60 DEG C, relative density is 1.20-1.30 thick paste, and add appropriate amount of starch, dry, pulverize, get dry extract powder;
(4) add the magnesium stearate of 1% again, mixing, incapsulates, to obtain final product.
2. treat the Chinese medicinal composition preparation of viral hepatitis according to claim 1, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 25-40 part, Herba Centellae 15-25 part, Herba Hyperici Japonici 15-25 part, Herba Artemisiae Scopariae 10-18 part, Polyporus 10-18 part, Herba Taxilli 12-18 part, Radix Puerariae 15-25 part, Radix Glycyrrhizae 4-6 part.
3. according to claim 1 or 2, treat the Chinese medicinal composition preparation of viral hepatitis, it is characterized in that, raw material is made up of the Chinese medicinal components of following weight portion: Radix Cudraniae 30 parts, Herba Centellae 20 parts, Herba Hyperici Japonici 20 parts, Herba Artemisiae Scopariae 15 parts, Polyporus 15 parts, Herba Taxilli 15 parts, Radix Puerariae 20 parts, 5 parts, Radix Glycyrrhizae.
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Cited By (3)
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CN104840761A (en) * | 2015-06-08 | 2015-08-19 | 李晓杰 | Novel sandwiched moxibustion medicine cake |
CN105233078A (en) * | 2015-11-24 | 2016-01-13 | 江崇礼 | Traditional Chinese medicine composition for treating viral hepatitis |
CN105770755A (en) * | 2016-04-24 | 2016-07-20 | 邹洪胜 | Traditional Chinese medicine composition for treating viral hepatitis |
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CN101711797A (en) * | 2009-10-23 | 2010-05-26 | 刘小杨 | Medicine for treating hepatitis B |
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Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104840761A (en) * | 2015-06-08 | 2015-08-19 | 李晓杰 | Novel sandwiched moxibustion medicine cake |
CN105233078A (en) * | 2015-11-24 | 2016-01-13 | 江崇礼 | Traditional Chinese medicine composition for treating viral hepatitis |
CN105770755A (en) * | 2016-04-24 | 2016-07-20 | 邹洪胜 | Traditional Chinese medicine composition for treating viral hepatitis |
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