CN101711797A - Medicine for treating hepatitis B - Google Patents

Abstract

The invention belongs to a medicine for treating hepatitis B in pharmaceuticals, which comprises radix bupleuri, buffalo horn, radix notoginseng, phyllanthus urinaria, placenta, oriental wormwood, carapax amydae, madras grangea, schisandra fruit, cudrania root, radix salviae miltiorrhizae and licorice. The medicine is a pure traditional Chinese medicine preparation and has no toxic or side effect. By oral administration, viruses are thoroughly removed, and the aim of radical cure of the hepatitis B is achieved.

Description

A kind of medicine for the treatment of hepatitis B

Technical field:

The present invention relates to a kind of medicine for the treatment of hepatitis B, belong to pharmaceuticals.

Background technology:

At present, still do not have medicine in the world and can effect a radical cure hepatitis B, it is movable that medicine just suppresses virus, and can not thoroughly remove virus; The medicine of anti-hepatitis virus is still immature at present; Still the specific medicament that does not have at present disposable thorough healing hepatitis B in the world; Our employed antiviral drugs role just suppresses virus but not eliminates; Attempt to remove as the treatment terminal point unrealistic fully with hepatitis B virus; Hepatitis B is international disease, but up to now, and any medicine or Therapeutic Method all are difficult to make all patients through long-term antiviral therapy, reaches and keeps ideal therapeutic effect; Existing medicine also all can not thoroughly be removed virus, just suppresses it and duplicates; Therefore, the medical effect to hepatitis B still is relatively poor.

Summary of the invention:

The purpose of this invention is to provide a kind of medicine for the treatment of hepatitis B, is pure Chinese medicinal preparation, without any side effects, by for oral administration, thoroughly removes virus, hepatitis B is reached the purpose of radical cure.

Technical scheme of the present invention is: be made up of Radix Bupleuri, Cornu Bubali, Radix Notoginseng, Cacumen Securinegae Suffruticosae, Placenta Hominis, Herba Artemisiae Scopariae, Carapax Trionycis, Herba Hyperici Japonici, Fructus Schisandrae Chinensis, Radix Cudraniae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae; Mix the Radix Bupleuri decoction pieces thoroughly (Radix Bupleuri is 100: 12 with the ratio of vinegar) with vinegar, put in the pot and fry to vinegar exhaustion and little doing, take out, dry with slow fire; Cornu Bubali is rived, after the hot-water soak, removes and to chamfer plug, residual meat, handle clean, the pound sheet, drying is placed in the fresh urine of healthy children below ten years old soaked 24 hours, took out, and cleaned, and shone or dried; The Placenta Hominis of the thick little color aquatic foods of healthy puerpera is cleaned, removed fascia, needle or sever anyhow umbilical cord blood vessel on every side, in running water, be washed till repeatedly the blood water purification clear till, tie up, put into boiling water and boil when Placenta Hominis floats and take out, put on the wire gauze with the low baking temperature roasting to bubble, loose getting final product; Carapax Trionycis is soaked a few days with clear water, change water every day once, strike off attached meat, clean, dry, other gets clean sand and goes into pot and make popular, puts into clean Carapax Trionycis again, fries littlely to Carapax Trionycis surface to take out when yellow, sieve shakeout, the Carapax Trionycis that will fry is put and is pulled out after the vinegar part omitted is soaked, and the clear water rinsing is dried; Earlier Cornu Bubali, Carapax Trionycis were added decocting one hour (therebetween with in this prescription in addition ten herbal medicines put in the clear water soaked 30 minutes) after, adding ten herbal medicines in addition that soaked fried in shallow oil one hour together, fry in shallow oil to the medicinal liquid 200-250 milliliter, pour out medicinal liquid, add water and whole 12 herbal medicines again with frying in shallow oil, twice decoction being taken warmly sooner or later divided in the twice mixed clarification of medicinal liquid back.

Advantage of the present invention is: (1) is pure Chinese medicinal preparation, and is without any side effects; (2) raw material sources are wide, and production cost is low; (3) taking convenience, the patient is acceptant; (4) evident in efficacy, can thoroughly eradicate source of disease.

The specific embodiment:

Embodiment: mix the Radix Bupleuri decoction pieces thoroughly (Radix Bupleuri is 100: 12 with the ratio of vinegar) with vinegar, put in the pot and fry to vinegar exhaustion and little doing, take out, dry with slow fire; Cornu Bubali is rived, after the hot-water soak, removes and to chamfer plug, residual meat, handle clean, the pound sheet, drying is placed in the fresh urine of healthy children below ten years old soaked 24 hours, took out, and cleaned, and shone or dried; The Placenta Hominis of the thick little color aquatic foods of healthy puerpera is cleaned, removed fascia, needle or sever anyhow umbilical cord blood vessel on every side, in running water, be washed till repeatedly the blood water purification clear till, tie up, put into boiling water and boil when Placenta Hominis floats and take out, put on the wire gauze with the low baking temperature roasting to bubble, loose getting final product; Carapax Trionycis is soaked a few days with clear water, change water every day once, strike off attached meat, clean, dry, other gets clean sand and goes into pot and make popular, puts into clean Carapax Trionycis again, fries littlely to Carapax Trionycis surface to take out when yellow, sieve shakeout, the Carapax Trionycis that will fry is put and is pulled out after the vinegar part omitted is soaked, and the clear water rinsing is dried; Earlier Cornu Bubali, Carapax Trionycis were added decocting one hour (therebetween with in this prescription in addition ten herbal medicines put in the clear water soaked 30 minutes) after, adding ten herbal medicines in addition that soaked fried in shallow oil one hour together, fry in shallow oil to 250 milliliters of medicinal liquids, pour out medicinal liquid, add water and whole 12 herbal medicines again with frying in shallow oil, twice decoction being taken warmly sooner or later divided in the twice mixed clarification of medicinal liquid back;

Radix Bupleuri in this prescription is gone into liver, gallbladder meridian, reach irritability because of transferring, unclog and readjust the stagnation of QI, so the effect of dispersing the stagnated live-QI to relieve the stagnation of QI is arranged, be used for depression of liver-QI, chest and diaphragm is full vexed, distending pain over the hypochondrium, hepatic depression and blood deficiency, dysfunction of the spleen in transportation, the bupleurumol composition that it contains can improve the rat liver function, have easypro, receive, the effect of soft liver spleen, low dose of (6-1.2g) can reach the purpose of the soft liver spleen that relaxes, its fatty acids has antiinflammation, contained saikoside has analgesic activity, saikoside 200-800 milligram/kilogram is oral to have sure refrigeration function to mice, polysaccharide component in the Radix Bupleuri has the anti-pain effect of bursting, the macrophage activation effect, remove the immune complex effect, Radix Bupleuri is in treatment hepatitis, there is better effects the catarrhal jaundice aspect, and Radix Bupleuri extractum points out it can suppress the immunological liver cell injury in experiment in vitro; Cornu Bubali GUIXIN, Liver Channel, join the army into blood, its main constituent keratin, peptide class, animal glue have the effect of heat-clearing and toxic substances removing removing heat from blood, can clear away heart-fire, liver, stomach three be through burning hot, especially can removing summer-heat noxious heat in the blood system, take safety, few side effects, Cornu Bubali decoct and Cornu Bubali extract have the effect of strengthening contractility to the heart of isolated frog heart, and Cornu Bubali all has cardiotonic to the normal or weak heart of rabbit, but comparatively obvious to weak heart effect; Radix Notoginseng goes into liver, stomach warp, the effect that antiinflammatory, antitumor, subduing swelling and relieving pain, hemostasia and dissipation blood stasis are arranged, zoopery proves, its contained arasaponin, flavonoid glycoside, alkaloid can improve platelet, cardiotonic is arranged, effective to blood fat reducing and cholesterol, the effect that suppresses and eliminate immune complex and infringement thereof is arranged, can obviously increase coronary flow, lower coronary resistance, decreased heart rate, bring high blood pressure down, reduce the myocardial oxygen consumption rate; Cacumen Securinegae Suffruticosae is gone into liver, lung meridian, has that suppressing the hyperactive liver makes eye bright, an effect of eliminating dampness and diuresis, heat-clearing and toxic substances removing, to treating the observation of acute and chronic hepatitis, has strengthened curative effect after adding this product in this prescription through clinical; Placenta Hominis is gone into liver, lung, kidney channel, blood yiqi is arranged, the effect of the kidney invigorating and essence nourishing, be used for deficiency of the liver and kindey, osteopyrexia and fever, its contained albumen, calcium, vitamin, thyroliberin, multiple antibody and immune factor, has the strengthening by means of tonics function, can suppress multiple virus infecting to human body cell, its immunization that has energy enhancing body resistance, have the effect of antianaphylaxis illness concurrently, Placenta Hominis also has good result for anemia, in addition, portal vein cirrhotic ascites and schistosomicide early stage liver cirrhosis ascites also there is certain curative effect, contained interferon in the Placenta Hominis gamma globulin, can be used for prevention or control viral infection clinically, also contain lysozyme in the Placenta Hominis, endotoxin also there is the certain protection effect to the injury of rat, take off the hydrochloric acid hydrolysis product that refers to the back Placenta Hominis and give rats by intraperitoneal injection, the liver fat deposit that carbon tetrachloride and ethylmercapto group Gamma Amino Butyric Acid are caused has the obvious suppression effect, the pepsin digestion liquid of cold preservation Placenta Hominis, aqueous extract and 70% acetone extract predict with Warburg apparatus, can promote liver, the heart, the breathing of few kinds of tissues such as brain and saccharomycetic breathing; Herba Artemisiae Scopariae goes into liver, gallbladder, spleen, stomach warp, its contained effective ingredient Herba Artemisiae Scopariae have the effect of removing damp-heat, promoting the function of the gallbladder to alleviate jaundice, have powerful refrigeration function and hypotensive effect concurrently, be used for obviously mitigation symptoms of infectious hepatitis, its ingredient chlorogenic acid and caffeic acid can impel biliary secretion to increase, and the Herba Artemisiae Scopariae decoct is to CCl ₄Due to experimental hepatic injury the improvement effect is arranged, can reduce white mice CCl ₄The mortality rate of toxic hepatitis, rabbit there is the liver cell regeneration of promotion effect, Herba Artemisiae Scopariae volatile oil can make hepatitis rabbit appetite increase, in addition, the capillarisin composition has very strong activity aspect antitumaous effect, Herba Artemisiae Scopariae extractum is transplanted Meth A tumor proliferation to the Balb/c mice inhibitory action, and Herba Artemisiae Scopariae can make serum ornitrol and beta lipoprotein descend, to jaundice disappearance regulating liver-QI, gallbladder dwindles that positive effect is arranged; Carapax Trionycis is gone into liver, spleen blood system, the effect that nourishing YIN for suppressing the hyperactive YANG, hard masses softening and resolving, suppressing the hyperactive liver to relieve the wind syndrome are arranged, be used for hectic fever due to YIN-deficiency consumptive fever, stirring of wind due to deficiency of YIN, lump in the abdomen mass beside the umbilicus, its contained keratin, animal glue, vitamin D, iodine matter etc. can suppress connective tissue proliferation, plays the effect of soft liver, spleen, so be used for the hepatosplenomegaly of abdomen stasis of blood piece and chronic hepatitis, liver cirrhosis therapeutical effect is arranged all, and can promote plasma albumin, and prolong the immunoglobulin half life, being used for albumen that hepatitis merges anemia, to be inverted the patient effective; Herba Hyperici Japonici is gone into liver, gallbladder meridian, its contained one-tenth jaundice ketone, lactone (coumarin), tannin, anthraquinone, aminoacid, phenols etc. have the effect of dampness removing jaundice eliminating, heat-clearing and toxic substances removing, be used for the treatment of infectious hepatitis curative effect better (icteric or non-icteric type all can), delay property, chronic hepatitis etc. are truly had certain curative effect, remarkable to reducing the glutamate pyruvate transaminase effect especially, and can alleviate hepatalgia; Fructus Schisandrae Chinensis is gone into the heart, liver, lung, kidney channel, has the lung benefiting kidney, tonify deficiency labor, the effect of born fluid, be used for night sweat due to yin deficiency or spontaneous perspiration due to yang insufficiency, deficiency of body fluid, xerostomia is done thirsty, its contained effective ingredient schizandrin has liver detoxification function, and the effects such as biosynthesis that promote lymphocyte transformation and promote hepatic protein and hepatic glycogen are arranged, but adrenal cortex reinforcing function and body are to the defence capability of nonspecific stimulation, and the effect that promotes bile secretion is arranged, can also influence carbohydrate metabolism, promote the liver glycogen heteroplasia, accelerating liver glycogen decomposes, make brain, the phosphorylation process of fructose and glucose is strengthened in liver and the muscular tissue, improve the level of blood lactic acid and blood glucose, in glucose test to rabbit, its extract can improve the utilization of body to sugar, zoopery proves that a small amount of Fructus Schisandrae Chinensis can improve the activeness of trained reflex, improves corticocerebral ability to work, simultaneously, excited respiratory system is regulated cardiovascular system morbid state physiological function and is improved not normal blood circulation, brings high blood pressure down, and the circulatory failure person is had the blood pressure effect that raises rather significantly, its to hepatitis convalescent period transaminase Gao Erjiu not the recuperator positive effect is also arranged; Radix Cudraniae has invigorating spleen and reinforcing stomach, cool the blood dissipate blood stasis, relaxing muscles and tendons to promote blood circulation, and the effect of expelling wind and removing dampness to acute, chronic hepatitis, is used through clinical comparison, behind the adding Radix Cudraniae, has strengthened curative effect in this prescription; The effect that Radix Cudraniae has invigorating spleen and reinforcing stomach, cool the blood dissipate blood stasis, relaxing muscles and tendons to promote blood circulation, removes the wind dampness removing, this prescription add this product after clinical in treating the observation of acute and chronic hepatitis, have accelerated the treatment process; Radix Salviae Miltiorrhizae is gone into the heart, the liver blood branch, blood-nourishing blood-generating is arranged, blood circulation and promoting silt, the effect of reducing swelling and alleviating pain, be used for lump in the abdomen, abdominal pain due to blood stasis, enclosed mass in the abdomen, hepatosplenomegaly, hypochondriac pain due to stagnation of liverQI, existing clinically be used for chronic hepatitis or early stage hepatitis interstitialis chronica has hepatosplenomegaly person more, can promote the liver physiology function to take a turn for the better, and can make the liver spleen of enlargement dwindle deliquescing, its contained TANSHINONES can be removed gathering and damaging of immune complex, improve peripheral circulation, coronary artery dilator and peripheral blood vessel, coronary blood flow increasing, bring high blood pressure down and activate fibrinolytic, blood sugar lowering, the Radix Salviae Miltiorrhizae decoct is in Bufo siccus whole body perfusion, the rabbit ear experiment of exsomatizing all has the blood vessel dilating effect, and Radix Salviae Miltiorrhizae decoct 0.5 gram/kilogram has hypoglycemic activity to the rabbit intramuscular injection; Radix Glycyrrhizae goes into spleen, stomach, the heart, lung meridian, invigorating the spleen and replenishing QI is arranged, pain relieving in slow, antiinflammatory, antiulcer, antiallergic action, the effect of heat-clearing and toxic substances removing and diuresis, can strengthen the drug effect of all medicines, but and coordinating the actions of various ingredients in a prescription, alleviate or reduce the bias or the toxicity of all medicines, under the various experiment conditions, Radix Glycyrrhizae all can suppress the propagation of virus, confirmed that this is relevant with inducing interferon, the contained glycyrrhizin of Radix Glycyrrhizae have Detoxication: its mechanism comprise glucuronic acid in conjunction with Detoxication, the class adrenocortical hormone sample effect of enoxolone, the glycyrrhizin adsorption, also can suppress the caused gastric acid secretion of histamine, be the treatment that the preparation of main constituent can be used for chronic hepatitis with the contained enoxolone of Radix Glycyrrhizae, the quiet notes of double-blind method one month, can improve liver function, zoopery is shown that it has inhibition CCl ₄Detrimental effect, inhibition macrophage and antibody-mediated cell injury effect, liver plasma membrane Stabilization and hepatocyte protection effect to liver; experiment shows; but enoxolone is the carcinogenic promoting agent effect of antagonism tumor formation second stage also, and caused animal liver injury all has protective effect to tetrachloroethylene, tuberculosis and ethanol.

Cure mainly the hepatitis B prescription: Radix Bupleuri 3-12g, Cornu Bubali 30-120g, Radix Notoginseng 1-3g, Cacumen Securinegae Suffruticosae 15-30g, Placenta Hominis 1-5g, Herba Artemisiae Scopariae 15-30g, Carapax Trionycis 9-24g, Herba Hyperici Japonici 15-45g, Fructus Schisandrae Chinensis 3-9g, Radix Cudraniae 6-12g, Radix Salviae Miltiorrhizae 5-10g, Radix Glycyrrhizae 3-9g.

Claims (1)

1. the medicine of a treatment " hepatitis B " is characterized in that: be made up of Radix Bupleuri, Cornu Bubali, Radix Notoginseng, Cacumen Securinegae Suffruticosae, Placenta Hominis, Herba Artemisiae Scopariae, Carapax Trionycis, Herba Hyperici Japonici, Fructus Schisandrae Chinensis, Radix Cudraniae, Radix Salviae Miltiorrhizae, Radix Glycyrrhizae; Mix the Radix Bupleuri decoction pieces thoroughly (Radix Bupleuri is 100: 12 with the ratio of vinegar) with vinegar, put in the pot and fry to vinegar exhaustion and little doing, take out, dry with slow fire; Cornu Bubali is rived, after the hot-water soak, removes and to chamfer plug, residual meat, handle clean, the pound sheet, drying is placed in the fresh urine of healthy children below ten years old soaked 24 hours, took out, and cleaned, and shone or dried; The Placenta Hominis of the thick little color aquatic foods of healthy puerpera is cleaned, removed fascia, needle or sever anyhow umbilical cord blood vessel on every side, in running water, be washed till repeatedly the blood water purification clear till, tie up, put into boiling water and boil when Placenta Hominis floats and take out, put on the wire gauze with the low baking temperature roasting to bubble, loose getting final product; Carapax Trionycis is soaked a few days with clear water, change water every day once, strike off attached meat, clean, dry, other gets clean sand and goes into pot and make popular, puts into clean Carapax Trionycis again, fries littlely to Carapax Trionycis surface to take out when yellow, sieve shakeout, the Carapax Trionycis that will fry is put and is pulled out after the vinegar part omitted is soaked, and the clear water rinsing is dried; Earlier Cornu Bubali, Carapax Trionycis were added decocting one hour (therebetween with in this prescription in addition ten herbal medicines put in the clear water soaked 30 minutes) after, adding ten herbal medicines in addition that soaked fried in shallow oil one hour together, fry in shallow oil to the medicinal liquid 200-250 milliliter, pour out medicinal liquid, add water and whole 12 herbal medicines again with frying in shallow oil, twice decoction being taken warmly sooner or later divided in the twice mixed clarification of medicinal liquid back.