CN103721109B

CN103721109B - A kind of medicament for the treatment of chronic cholecystitis

Info

Publication number: CN103721109B
Application number: CN201410031825.XA
Authority: CN
Inventors: 陶鸿飞
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-01-23
Filing date: 2014-01-23
Publication date: 2015-10-14
Anticipated expiration: 2034-01-23
Also published as: CN103721109A

Abstract

The present invention relates to a kind of medicament for the treatment of chronic cholecystitis, it is made up by weight of following bulk drugs: Cor Cervi grass 10-20 part, Herba astilbes chinensis 10-20 part, Rhizoma Tupistrae Chinensis 10-20 part, Herba polygoni divaricati 10-20 part, Flos Jasmini Sambac 10-20 part, Herba Violae japonicae 5-15 part, Flos Rosae Chinensis 5-15 part, Herba Goodyerae Procerae 5-15 part, Citrus aurantium L. var. amara Engl. 1-10 part, Herba Melandrii Aprici 1-10 part, Semen sojae atricolor 1-10 part, the bean seedling 1-10 part that falls, Flos Chrysanthemi 1-10 part, Herba Scutellariae indicae 1-10 part, Stigma Maydis 1-10 part, Herba Tricyrtis Pilosae 1-10 part, Radix Pulsatillae 1-5 part, cold certain kind of berries 1-5 part, Radix Angelicae Sinensis 1-5 part and Radix oxysporae paniculatae 1-5 part.Rationally, definite effect, is extremely suitable for large-scale promotion clinically to the medicament composition for the treatment of chronic cholecystitis of the present invention.

Description

A kind of medicament for the treatment of chronic cholecystitis

Technical field

The present invention relates to field of medicaments, relate in particular to a kind of medicament for the treatment of chronic cholecystitis.

Background technology

Chronic cholecystitis refers to the chronic inflammatory disease of gallbladder, is the modal disease of one of gallbladder.Common clinical manifestation is the right flank distension of repeated relapsing, dull pain, feels sick, abdominal distention.Current clinical multiple, need new medicine.

Summary of the invention

The object of this invention is to provide a kind of medicament for the treatment of chronic cholecystitis.

In order to realize object of the present invention, the invention provides a kind of medicament for the treatment of chronic cholecystitis, it is made up by weight of following bulk drugs: Cor Cervi grass 10-20 part, Herba astilbes chinensis 10-20 part, Rhizoma Tupistrae Chinensis 10-20 part, Herba polygoni divaricati 10-20 part, Flos Jasmini Sambac 10-20 part, Herba Violae japonicae 5-15 part, Flos Rosae Chinensis 5-15 part, Herba Goodyerae Procerae 5-15 part, Citrus aurantium L. var. amara Engl. 1-10 part, Herba Melandrii Aprici 1-10 part, Semen sojae atricolor 1-10 part, fall bean seedling 1-10 part, Flos Chrysanthemi 1-10 part, Herba Scutellariae indicae 1-10 part, Stigma Maydis 1-10 part, Herba Tricyrtis Pilosae 1-10 part, Radix Pulsatillae 1-5 part, cold certain kind of berries 1-5 part, Radix Angelicae Sinensis 1-5 part and Radix oxysporae paniculatae 1-5 part.

Preferably, the medicament for the treatment of chronic cholecystitis of the present invention is made up by weight of following bulk drugs: Cor Cervi grass 18 parts, Herba astilbes chinensis 15 parts, Rhizoma Tupistrae Chinensis 16 parts, Herba polygoni divaricati 15 parts, Flos Jasmini Sambac 12 parts, Herba Violae japonicae 10 parts, Flos Rosae Chinensis 10 parts, Herba Goodyerae Procerae 10 parts, Citrus aurantium L. var. amara Engl. 9 parts, Herba Melandrii Aprici 9 parts, 8 parts, Semen sojae atricolor, the bean seedling 7 parts that falls, Flos Chrysanthemi 8 parts, Herba Scutellariae indicae 7 parts, Stigma Maydis 6 parts, Herba Tricyrtis Pilosae 6 parts, the Radix Pulsatillae 3 parts, the cold certain kind of berries 3 parts, Radix Angelicae Sinensis 3 parts and Radix oxysporae paniculatae 3 parts.

More preferably, described medicament can be tablet, dispersible tablet, disintegrating tablet, rapidly dissolving tablet, enteric coatel tablets, capsule or decoction.

In the present compositions, Cor Cervi grass, Herba astilbes chinensis, Rhizoma Tupistrae Chinensis, Herba polygoni divaricati are monarch drug; Flos Jasmini Sambac, Herba Violae japonicae, Flos Rosae Chinensis, Herba Goodyerae Procerae are ministerial drug; Citrus aurantium L. var. amara Engl., Herba Melandrii Aprici, Semen sojae atricolor, the bean seedling that falls, Flos Chrysanthemi, Herba Scutellariae indicae, Stigma Maydis, Herba Tricyrtis Pilosae are adjuvant drug; The Radix Pulsatillae, the cold certain kind of berries, Radix Angelicae Sinensis and Radix oxysporae paniculatae are for making medicine, and various ingredient exerts synergism is to produce optimum efficiency.

In order to understand the present invention better, with reference to " Chinese medicine voluminous dictionary " second edition (Shanghai science tech publishing house, 2005), the explanation of some crude drug used in the present invention sees the following form:

Rationally, definite effect, is extremely suitable for large-scale promotion clinically to the medicament composition for the treatment of chronic cholecystitis of the present invention.

Detailed description of the invention

The present invention is further illustrated below by embodiment.It should be understood that embodiments of the invention are for illustration of the present invention instead of limitation of the present invention.Essence according to the present invention all belongs to the scope of protection of present invention to the simple modifications that the present invention carries out.Unless otherwise stated, the percent in the present invention is percetage by weight.

Embodiment decoction of the present invention

Get Cor Cervi grass 18 grams, Herba astilbes chinensis 15 grams, Rhizoma Tupistrae Chinensis 16 grams, Herba polygoni divaricati 15 grams, Flos Jasmini Sambac 12 grams, Herba Violae japonicae 10 grams, Flos Rosae Chinensis 10 grams, Herba Goodyerae Procerae 10 grams, Citrus aurantium L. var. amara Engl. 9 grams, Herba Melandrii Aprici 9 grams, 8 grams, Semen sojae atricolor, the bean seedling 7 grams that falls, Flos Chrysanthemi 8 grams, Herba Scutellariae indicae 7 grams, Stigma Maydis 6 grams, Herba Tricyrtis Pilosae 6 grams, the Radix Pulsatillae 3 grams, the cold certain kind of berries 3 grams, Radix Angelicae Sinensis 3 grams and Radix oxysporae paniculatae 3 grams, add 12000 milliliters, water, heat 6 hours at 90 DEG C in the flask that condenser is housed, filter, filtrate is decoction of the present invention.

Experimental example

Physical data

60 routine chronic cholecystitis patients are clinic case, women 30 example, male 30 example.Treatment group 30 example, male 15 example, women 15 example; Matched group 30 example, male 15 example, women 15 example.Age 25-61 year, average 46 years old.60 routine patients, all through color ultrasound indagation, are diagnosed as chronic cholecystitis, all do not include in other pathological changes persons.Above-mentioned patient divided into groups, treatment group and equal 30 examples of matched group, two groups of patients are in sex, age, the course of disease etc., and through statistical procedures P>0.05, there was no significant difference, has comparability.

Diagnostic criteria

Above case all with reference to " practical internal medicine " (the practical internal medicine [M] of Chen Haozhu. Beijing: People's Health Publisher .2009:9.) diagnostic criteria of the 13 edition.Specific standards: the right Upper abdominal pain of repeated relapsing, can take on the radiation of underfooting district to the right.Chang Yu after the meal, in rest pain.Can with symptoms such as Nausea and vomiting, but heating, jaundice are uncommon.Physical examination finds right upper quadrant of the abdomen tenderness, and Murphy can be had to levy (+).B ultrasonic measures gallbladder and common bile duct size, the thickness etc. of gallbladder wall is made a definite diagnosis.

Decoction obtained in the oral embodiment 1 for the treatment of group is treated, one day twice, oral 200 milliliters at every turn, continuously treatment 30 days.

The oral Liujunzi Tang of matched group is treated, one day twice, oral 200 milliliters at every turn, continuously treatment 30 days.

Curative effect determinate standard

According to " new Chinese medicine guideline of clinical investigations " (Zheng Xiao cornel. new Chinese medicine guideline of clinical investigations (trying) [S]. Beijing: China Medical Science Press, 2002; 4.) guideline of clinical investigations.Clinical recovery: symptom, sign disappear or substantially disappear; Effective: symptom, sign are obviously improved; Effective: symptom, sign all take a favorable turn; Invalid: symptom, sign are all not improved.

Result

Through treatment, the therapeutic outcome of two groups sees the following form:

Group	Number of cases	Clinical recovery	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	30	22	6	2	0	100
Matched group	30	7	9	8	6	80

Model case

Lee so-and-so, man, 38 years old, government civilian.In first visit on March 18 in 2013, the right flank distending pain of patient, felt sick tending to vomit January, and companion's abdominal distention coughs up gas, and stool matter is glued not well, once a day (without mucus, pus and blood).Ultrasound diagnosis: gallbladder 7.6cm × 3.6cm, wall thickness 0.8cm is fuzzy in capsule.Decoction obtained in oral embodiment 1 is treated, one day twice, oral 200 milliliters at every turn, continuously treatment 30 days.After treatment, through B ultrasonic check, gallbladder clear-cut, smooth, size and form is normal, right side flank distending pain, and feel sick, the transference cures such as abdominal distention, follow up a case by regular visits to after half a year and do not recur.

Wang, female, 45 years old, peasant.In first visit on May 20 in 2013, the right rib distension of patient, dull pain were uncomfortable, and more than February of feeling sick, accompany abdominal distention, cough up gas, limbs fatigue, mouth is sticky, and often bring out because excessive thinking or feelings will are easypro, increase the weight of, it is poor that anorexia is slept, and pale tongue with white fur is greasy, and stringy pulse delays.Ultrasound diagnosis: gallbladder 8.2cm × 4.8cm, wall thickness 0.9cm is fuzzy in capsule.Decoction obtained in oral embodiment 1 is treated, one day twice, oral 200 milliliters at every turn, continuously treatment 30 days.After treatment, through B ultrasonic check, gallbladder clear-cut, smooth, size and form is normal, right side flank distending pain, and feel sick, the transference cures such as abdominal distention, follow up a case by regular visits to after half a year and do not recur.

Chen, man, 29 years old, workman.In first visit on May 6 in 2013, more than right Upper abdominal pain distension April, because causing upper right abdomen ache after flu, anger, accompany right shoulder back distending pain, nauseating tending to vomit, bitter taste poor appetite, yellow fur was thick greasy, dimly red tongue, stringy pulse red tongue, yellow and thin fur, deep and stringy pulse.Ultrasound diagnosis: gallbladder 6.8cm × 3.9cm, wall thickness 0.6cm is fuzzy in capsule.Decoction obtained in oral embodiment 1 is treated, one day twice, oral 200 milliliters at every turn, continuously treatment 30 days.After treatment, through B ultrasonic check, gallbladder clear-cut, smooth, size and form is normal, and right Upper abdominal pain distension, the transference cure such as to feel sick, follow up a case by regular visits to after half a year and do not recur.

Claims

1. treat the medicament of chronic cholecystitis for one kind, it is characterized in that, it is made up by weight of following bulk drugs: Cor Cervi grass 10-20 part, Herba astilbes chinensis 10-20 part, Rhizoma Tupistrae Chinensis 10-20 part, Herba polygoni divaricati 10-20 part, Flos Jasmini Sambac 10-20 part, Herba Violae japonicae 5-15 part, Flos Rosae Chinensis 5-15 part, Herba Goodyerae Procerae 5-15 part, Citrus aurantium L. var. amara Engl. 1-10 part, Herba Melandrii Aprici 1-10 part, Semen sojae atricolor 1-10 part, the bean seedling 1-10 part that falls, Flos Chrysanthemi 1-10 part, Herba Scutellariae indicae 1-10 part, Stigma Maydis 1-10 part, Herba Tricyrtis Pilosae 1-10 part, Radix Pulsatillae 1-5 part, cold certain kind of berries 1-5 part, Radix Angelicae Sinensis 1-5 part and Radix oxysporae paniculatae 1-5 part.

2. the medicament for the treatment of chronic cholecystitis according to claim 1, it is characterized in that, it is made up by weight of following bulk drugs: Cor Cervi grass 18 parts, Herba astilbes chinensis 15 parts, Rhizoma Tupistrae Chinensis 16 parts, Herba polygoni divaricati 15 parts, Flos Jasmini Sambac 12 parts, Herba Violae japonicae 10 parts, Flos Rosae Chinensis 10 parts, Herba Goodyerae Procerae 10 parts, Citrus aurantium L. var. amara Engl. 9 parts, Herba Melandrii Aprici 9 parts, 8 parts, Semen sojae atricolor, the bean seedling 7 parts that falls, Flos Chrysanthemi 8 parts, Herba Scutellariae indicae 7 parts, Stigma Maydis 6 parts, Herba Tricyrtis Pilosae 6 parts, the Radix Pulsatillae 3 parts, the cold certain kind of berries 3 parts, Radix Angelicae Sinensis 3 parts and Radix oxysporae paniculatae 3 parts.