CN105030985A - Traditional Chinese medicine composition with effects of tonifying deficiency and promoting lactation and preparation method of traditional Chinese medicine composition - Google Patents
Traditional Chinese medicine composition with effects of tonifying deficiency and promoting lactation and preparation method of traditional Chinese medicine composition Download PDFInfo
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Abstract
The invention relates to a traditional Chinese medicine composition with the effects of tonifying deficiency and promoting lactation and a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following components in parts by weight: 180-220 parts of black-bone chicken, 22-35 parts of ginseng, 35-50 parts of astragalus, 10-20 parts of longan pulp and 15-30 parts of angelica sinensis. The traditional Chinese medicine composition has the effects of tonifying qi and nourishing blood as well as strengthening the body resistance and consolidating the constitution, is suitable for patients suffering from postnatal body deficiency with the symptoms of dispiritedness and lassitude and is proven to be exact in curative effect and free of toxic or side effect through clinical observation.
Description
Technical field
The present invention relates to the field of Chinese medicines, be specifically related to a kind of tonify deficiency and urge Chinese medicine composition of breast and preparation method thereof.
Background technology
Due to the energy expenditure in birth process, wound and hemorrhage, cause its vigour to be consumed, insufficiency of vital energy and blood, is called puerperal asthenia.Disease as: to be afraid of cold, aversion to wind, cold perspiration, soreness of the waist and knees, cold and pain in the lower abdomen, shortness of breath and palpitation, limbs fatigue, Hypomenorrhea, darkish complexion, leucorrhea is many, menstrual period edema, dim complexion, long speckle, hypo-ovaria, puerperal the symptom such as hyposexuality.
Puerpera's ferritic is weak, severe loss of blood, thin fluid injury, and empty sun is floating loose, and blood deficiency is appointed in punching, and vessels of the uterus loses supports, and puerperal, internal organs wound was dynamic, and hundred joints are hollow, and space between skin and muscles is unreal, instability of surface, and health preserving is careless slightly just various puerperal disease can occur.
Latter half of gestation, anemia of pregnant woman's body inner estrogen, Progesterone, 17-hydroxy-11-dehydrocorticosterone, thyroxine all can increase in various degree, in the process of pregnancy and delivery, in body, endocrinal environment there occurs change sharply, especially in 24 hours puerperal, declining rapidly in short-term of hormone in vivo level, causes the imbalance of organism endocrine, thus generation puerperal fever in puerperal and puerperal asthenia.
According to the feature of thin fluid injury, blood-stasis internal-depression, multiple deficiency and stasis, in line with the principle of " do not arrested puerperal, also do not forgotten puerperal ", determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs should be carried out in conjunction with the state of an illness to puerperal asthenia patient.
Jing-Yue Complete Works is said: " puerperal, QI and blood was all gone, and sincere many deficiency syndrome, so have empty person, had not empty person, complete there is real person, and this threes all, but when with demonstrate,proving with people, distinguish its deficiency and excess, with well-established law treatment, must not sincerity be held, the large benefit of general row, so that help heresy.”
Namely puerperal, many void should based on strongly invigorating QI and blood, but its medication must anti-stagnant heresy, help the fraud of heresy; Puerperal many stasis of bloods, when with the method for blood circulation promoting competent silt, the blood circulation promoting and blood stasis dispelling in right puerperal, must help again to nourish blood, make eliminating evil and just do not hinder, blood stasis dispelling and non-blood trouble.Selection drug, must look after QI and blood.Dissipating depression of QI does not too dissipate, and food stagnation removing doublely must hold up spleen, and cold relieving not too warm-dryness syndrome, heat clearing away is mistake bitter cold not.
Conveniently patient uses, and need provide a kind of effective medicament composing prescription, and provide a kind of preparation method that can improve the active component extraction ratio of medicine, to improve pharmaceutical effectiveness.
Summary of the invention
The object of this invention is to provide the Chinese medicine composition that a kind of tonify deficiency urgees breast.
The object of this invention is to provide the preparation method that a kind of tonify deficiency urgees the Chinese medicine composition of breast.
Another object of the present invention is to provide the Chinese medicine composition oral liquid formulations that a kind of tonify deficiency urgees breast.
Another object of the present invention is to provide the preparation method that a kind of tonify deficiency urgees the Chinese medicine composition oral liquid formulations of breast.
Provided by the invention for tonify deficiency urge breast Chinese medicine composition be made up of the raw material of Chinese medicine of following weight portion: the Gallus Domesticus of unhairing, pawl and intestinal 180 ~ 220 parts, Radix Ginseng 22 ~ 35 parts, the Radix Astragali 35 ~ 50 parts, Arillus Longan 10 ~ 20 parts, Radix Angelicae Sinensis 15 ~ 30 parts.
The preparation method step that tonify deficiency of the present invention urgees the Chinese medicine composition of breast is as follows:
1) Gallus Domesticus stripping and slicing, decocts with water 2 ~ 3 times, each 1 ~ 3 hour, decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, let cool, add ethanol and make alcohol content reach 30 ~ 80%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, cold preservation, for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 2 ~ 3 times, each 1 ~ 3 hour, and decocting liquid filters, filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, lets cool, adding ethanol makes alcohol content reach 30 ~ 80%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, and cold preservation is for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 1 ~ 3 time, each 1 ~ 3 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 30 ~ 80%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, after preparing with pharmaceutically acceptable carrier combination, add step 3) gained Radix Ginseng distillate, obtain Chinese medicine composition.
Preferably, described step 1), 2), 5) in add ethanol, make alcohol content reach 70%.
Preferably, method prepared by the carrier combination that described step 6) is pharmaceutically acceptable is: after four kinds of medicinal liquid mixing for subsequent use, add Mel, sucrose and sorbic acid, mixing, heating makes dissolving, lets cool, and filters, obtains filtrate.
Preferably, to urge the preparation method step of Chinese medicine composition of breast as follows for tonify deficiency of the present invention:
1) Gallus Domesticus stripping and slicing, decocts with water 3 times, and first and second time each 1.5 hours, 1 hour third time, decocting liquid filters, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, lets cool, adds ethanol and make alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.08 ~ 1.18, and cold preservation is for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 3 times, and first and second time each 2 hours, 1 hour third time, decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.08 ~ 1.18, let cool, add ethanol and make alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.08 ~ 1.18, cold preservation, for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.08 ~ 1.18, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 70%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.08 ~ 1.18, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel, sucrose and sorbic acid, mixing, heating makes dissolving, lets cool, and filter, filtrate adds step 3) gained Radix Ginseng distillate, obtains Chinese medicine composition.
Present invention also offers in Chinese medicine composition preparation process, the another kind of extracting method of Gallus Domesticus active component:
Gallus Domesticus stripping and slicing, decocts with water 1 ~ 3 hour, lets cool to 40-60 DEG C, adds protease, stir evenly, and insulation 0.5-4 hour, gets suspension, deactivation, filters, and when filtrate is concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, and cold preservation is for subsequent use.
Preferably, described Gallus Domesticus lets cool temperature after decocting is 50 DEG C.
Preferably, described protease is one or more in acid protease, neutral protease, alkaline protease, papain.
The Chinese medicine composition oral liquid formulations that tonify deficiency provided by the invention urgees breast is prepared from by Chinese medicine composition of the present invention and pharmaceutically acceptable carrier combination.
The Chinese medicine composition that a kind of tonify deficiency provided by the invention urgees breast has the following advantages:
1, compositions provided by the invention can significantly improve phagocytic index and the phagocytic rate of Turnover of Mouse Peritoneal Macrophages, illustrate and adopt the said composition prepared of technical solution of the present invention can the non-specific immunity of enhancing body, effect is better than prior art, and has synergy.
2, embodiment of the present invention sample osthole nitrogen content, ferulaic acid content are all significantly higher than comparative example, and the nitrogen content of embodiment 5-7 sample, ferulaic acid content are all higher than embodiment 1-4.Experimental result prompting adopts the technology of the present invention to extract nitrogen content, ferulaic acid content in gained Chinese medicine composition and compared with prior art, extracts comparatively completely, and the sample nitrogen content adopting enzyme lifting manipulation to extract, ferulaic acid content are higher than water extraction gained sample.
3, the total therapeutic effect of clinical observation compares, and the symptom integral for the treatment of before and after 1 group and treatment 2 groups treatment obviously reduces, and clinical cure rate and obvious effective rate generally improve, and compare with matched group, and treatment group has significant difference; And the curative effect for the treatment of 2 groups is better than treatment 1 group.Hematochrome, the platelet count for the treatment of group also present significant raising, also have significant difference than matched group.Result shows the present invention and compares with matched group, and the present invention all has good curative effect at the treatment syndrome of deficiency of QI of women, syndrome of deficiency of blood and deficiency of both QI and blood.
4, the present invention is Chinese medicine preparation, has effect of benefiting QI and nourishing blood, strengthening the body resistance, the person that is applicable to puerperal asthenia, and effectively can treat the symptoms such as spiritlessness and weakness, be a kind of new Chinese medicine be worthy to be popularized.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
If no special instructions, the concentration of alcohol in the present invention is percent by volume.
embodiment 1:
Raw material is taken: the Gallus Domesticus 18kg of unhairing, pawl and intestinal, Radix Ginseng 2.2g, Radix Astragali 3.5kg, Arillus Longan 1kg, Radix Angelicae Sinensis 1.5kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 3 times, and amount of water is 10 times of medical material gross weight, first and second time each 1.5 hours, 1 hour third time, and decocting liquid filters, filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.10, lets cool, adding ethanol makes alcohol content reach 70%, stirs evenly, and leaves standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.18, cold preservation, for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 3 times, and amount of water is 10 times of medical material gross weight, and first and second time each 2 hours, 1 hour third time, decocting liquid filters, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.08, lets cool, adds ethanol and make alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.08, and cold preservation is for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.08, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 70%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.08, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, let cool, filter, filtrate adds step 3) gained Radix Ginseng distillate, mixing, add water to 100 liters, stir evenly, embedding, obtain oral liquid.
embodiment 2:
Raw material is taken: the Gallus Domesticus 22kg of unhairing, pawl and intestinal, Radix Ginseng 3.5g, Radix Astragali 5kg, Arillus Longan 2kg, Radix Angelicae Sinensis 3kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 3 times, and amount of water is 8 times of medical material gross weight, first and second time each 1.5 hours, 1 hour third time, and decocting liquid filters, filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.30, lets cool, adding ethanol makes alcohol content reach 70%, stirs evenly, and leaves standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.28, cold preservation, for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 3 times, and amount of water is 8 times of medical material gross weight, and first and second time each 2 hours, 1 hour third time, decocting liquid filters, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.18, lets cool, adds ethanol and make alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.18, and cold preservation is for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.18, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 70%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.18, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, let cool, filter, filtrate adds step 3) gained Radix Ginseng distillate, mixing, add water to 100 liters, stir evenly, embedding, obtain oral liquid.
embodiment 3:
Raw material is taken: the Gallus Domesticus 18kg of unhairing, pawl and intestinal, Radix Ginseng 3.5g, Radix Astragali 3.5kg, Arillus Longan 2kg, Radix Angelicae Sinensis 1.5kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 2 times, and amount of water is 6 times of medical material gross weight, each 3 hours, decocting liquid filtered, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.30, lets cool, adds ethanol and make alcohol content reach 30%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.30, and cold preservation is for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 2 times, and amount of water is 6 times of medical material gross weight, each 3 hours, decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.30, let cool, add ethanol and make alcohol content reach 30%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.30, cold preservation, for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.30, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 30%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.30, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, lets cool, and filters, filtrate adds step 3) gained Radix Ginseng distillate, mixing, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
embodiment 4:
Raw material is taken: the Gallus Domesticus 22kg of unhairing, pawl and intestinal, Radix Ginseng 2.2g, Radix Astragali 5kg, Arillus Longan 2kg, Radix Angelicae Sinensis 3kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 2 times, and amount of water is 12 times of medical material gross weight, each 2 hours, decocting liquid filtered, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.10, lets cool, adds ethanol and make alcohol content reach 80%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.10, and cold preservation is for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 2 times, and amount of water is 12 times of medical material gross weight, each 1 hour, decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.05, let cool, add ethanol and make alcohol content reach 80%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.05, cold preservation, for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 1 time, and the time is 3 hours, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.05, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 80%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.05, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, lets cool, filter, filtrate adds step 3) gained Radix Ginseng distillate, and mixing, adds 3 times that purified water ad pond om is medical material gross weight, fill, obtains mixture of the present invention.
embodiment 5:
Raw material is taken: the Gallus Domesticus 18kg of unhairing, pawl and intestinal, Radix Ginseng 2.2g, Radix Astragali 3.5kg, Arillus Longan 1kg, Radix Angelicae Sinensis 1.5kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 1 hour, and amount of water is 10 times of medical material gross weight, lets cool to 50 DEG C, adds neutral protease, stir evenly, and is incubated 4 hours, gets suspension, deactivation, filters, and when filtrate is concentrated into 50 DEG C, relative density is 1.10, and cold preservation is for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 3 times, and amount of water is 10 times of medical material gross weight, and first and second time each 2 hours, 1 hour third time, decocting liquid filters, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.08, lets cool, adds ethanol and make alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.08, and cold preservation is for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.08, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) other medicinal liquids remaining after getting supernatant, add ethanol and make alcohol content reach 70%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.08, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, let cool, filter, filtrate adds step 3) gained Radix Ginseng distillate, mixing, add water to 100 liters, stir evenly, embedding, obtain oral liquid.
embodiment 6:
Raw material is taken: the Gallus Domesticus 22kg of unhairing, pawl and intestinal, Radix Ginseng 3.5g, Radix Astragali 5kg, Arillus Longan 2kg, Radix Angelicae Sinensis 3kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 3 hours, and amount of water is 8 times of medical material gross weight, lets cool to 40 DEG C, adds acid protease, stir evenly, and is incubated 0.5 hour, gets suspension, deactivation, filters, and when filtrate is concentrated into 50 DEG C, relative density is 1.30, and cold preservation is for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 2 times, and amount of water is 8 times of medical material gross weight, each 3 hours, decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.30, let cool, add ethanol and make alcohol content reach 30%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.30, cold preservation, for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.30, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) other medicinal liquids remaining after getting supernatant, add ethanol and make alcohol content reach 30%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.30, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, lets cool, and filters, filtrate adds step 3) gained Radix Ginseng distillate, mixing, adds supplementary product starch, ethanol, Pulvis Talci, obtained tablet.
embodiment 7:
Raw material is taken: the Gallus Domesticus 18kg of unhairing, pawl and intestinal, Radix Ginseng 3.5g, Radix Astragali 3.5kg, Arillus Longan 2kg, Radix Angelicae Sinensis 1.5kg by following deal;
1) Gallus Domesticus stripping and slicing, decocts with water 2 hours, and amount of water is 6 times of medical material gross weight, lets cool to 60 DEG C, adds alkaline protease, stir evenly, and is incubated 2 hours, gets suspension, deactivation, filters, and when filtrate is concentrated into 50 DEG C, relative density is 1.10, and cold preservation is for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 3 times, and amount of water is 6 times of medical material gross weight, and first and second time each 2 hours, 1 hour third time, decocting liquid filters, and filtrate merges, when being concentrated into 50 DEG C, relative density is 1.18, lets cool, adds ethanol and make alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.18, and cold preservation is for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 3 times, each 1 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.18, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) other medicinal liquids remaining after getting supernatant, add ethanol and make alcohol content reach 70%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.18, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, lets cool, and filters, filtrate adds step 3) gained Radix Ginseng distillate, mixing, adds supplementary product starch, silicon dioxide, ethanol, dextrin, magnesium stearate, incapsulates shell, obtained capsule.
Comparative example 1:
Raw material is taken: the Gallus Domesticus 18kg of unhairing, pawl and intestinal, Radix Ginseng 2.2g, Radix Astragali 3.5kg, Arillus Longan 1kg, Radix Angelicae Sinensis 1.5kg by following deal;
Gallus Domesticus stripping and slicing, Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan, Radix Ginseng decocts with water 3 times, amount of water is 10 times of medical material gross weight, first, each 1.5 hours of secondary, 1 hour third time, decocting liquid filters, filtrate merges, when being concentrated into 50 DEG C, relative density is 1.10, let cool, adding ethanol makes alcohol content reach 70%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.18, add Mel 10kg, sucrose 10kg and sorbic acid 0.3kg, mixing, heating makes dissolving, let cool, filter, filtrate adds water to 100 liters, stir evenly, embedding, obtain oral liquid.
experimental example 1: Different Extraction Method effect experiment compares
With the Gallus Domesticus of different extracting method to unhairing, pawl and intestinal, Radix Ginseng, the Radix Astragali, Arillus Longan, Radix Angelicae Sinensis extracts, by the raising body constitution of the more different extract of animal effect experiment, the effect of increase immunity.
Test method: Turnover of Mouse Peritoneal Macrophages engulfs chicken red blood cell experiment
Analysis result is in table 1.
Table 1 result shows:
Compared with Normal group, embodiment 1 group, embodiment 5 groups, the Peritoneal macrophage function of comparative example 1 group of mice, phagocytic index have increasing in various degree (compare with Normal group,
p<0.05 or
p<0.01);
Compared with comparative example 1 group, embodiment 1,5 liang respectively group mice Peritoneal macrophage function (
p<0.05); And the peritoneal macrophage phagocytic index of embodiment 5 groups of mices obviously increase in embodiment 1 group (
p<0.05).
Experimental result shows: compositions provided by the invention can significantly improve phagocytic index and the phagocytic rate of Turnover of Mouse Peritoneal Macrophages, illustrate and adopt the said composition prepared of technical solution of the present invention can the non-specific immunity of enhancing body, effect is better than prior art, and has synergy.
experimental example 2: the comparison that different preparation method gained sample size measures
1 sample grouping
Embodiment 1-7, comparative example 1.
2 contrast projects: nitrogen content, ferulaic acid content.
3 experimental results, in table 2
Table 2 result shows: embodiment of the present invention sample osthole nitrogen content, ferulaic acid content are all significantly higher than comparative example, and the nitrogen content of embodiment 5-7 sample, ferulaic acid content are all higher than embodiment 1-4.Experimental result prompting adopts the technology of the present invention to extract nitrogen content, ferulaic acid content in gained Chinese medicine composition and compared with prior art, extracts comparatively completely, and the sample nitrogen content adopting enzyme lifting manipulation to extract, ferulaic acid content are higher than water extraction gained sample.
clinical trial
One, physical data
Select patient 250 example, wherein 139 examples are observed in outpatient service, and be hospitalized for observation 111 examples.Stochastic averagina is divided into treatment 1 group, treats 2 groups and matched group, and three groups of ages, the course of disease, the state of an illness, symptom, sign, tongue arteries and veins compare, and P>0.05, all has comparability.
Two, case selection standard
(1) diagnostic criteria:
According to main pharmacodynamics of the present invention, select have the women of the deficiency of vital energy, blood deficiency and QI and blood deficiency syndrome to be the object of observation, its dialectical " dialectical standard of Chinese medicine deficiency-syndrome " according to working out with reference to Zhengzhou meeting in 1986, is specially:
Syndrome of deficiency of QI:
Primary symptom: spiritlessness and weakness, deficiency of QI with disinclination to talk, spontaneous perspiration, menoxenia or clear and thin leucorrhea, enlarged tongue or have tooth to print, deficient pulse is unable.
Secondary disease: language is low, breathes hard, defecation inability, easy diseases caused by exogenous pathogenic factor ailment said due to cold or exposure.
Establish this syndrome and must meet primary symptom three, or meet primary symptom two and add time disease two.
Syndrome of deficiency of blood:
Primary symptom: pale complexion, dim at the moment when standing up, light through color, matter is thin, and words color is talked, thready pulse.
Secondary disease: severe palpitation, insomnia, dreaminess of sleeping is disturbed, forgetful.
Establish this syndrome and must meet primary symptom three, or meet primary symptom two and add time disease two.
According to above-mentioned dialectical foundation, in this clinical trial treatment group 200 example, the deficiency of vital energy 60 example, blood deficiency 16 example, QI and blood deficiency 124 example; In matched group 50 example, the deficiency of vital energy 17 example, blood deficiency 8 example, QI and blood deficiency 25 example.
Three, efficacy assessment standard
Adopt integration method, remember 1 point by each primary symptom, secondary disease remembers 0.5 point, all by primary and secondary symptom scores accumulated before and after treatment, then carries out statistical procedures.Carry out efficacy determination by following standard simultaneously
1, fully recover: deficiency syndrome, the symptom integral comprising syndrome of deficiency of QI, syndrome of deficiency of blood or deficiency of both QI and blood all disappears.
2, effective: the symptom integral of deficiency syndrome reduces more than 2/3rds.
3, effective: the symptom integral of deficiency syndrome reduces less than 2/3rds.
4, invalid: the symptom integral of deficiency syndrome is without minimizing.
Four, test method
1, divide into groups: treat 1 group: the embodiment of the present invention 1,10ml/ time, 3 times/day
Treat 2 groups: the embodiment of the present invention 5,10ml/ time, 3 times/day
Matched group: Bazhen Pills, Hu Qingyu Pharmaceutical Workshop, Hangzhou produces, 3g/ time, 3 times/day
2, the course for the treatment of: one month.
Five, observed result
The symptom integral of three groups compares in table 3, and obvious effective rate and total effective rate are in table 4, and the curative effect of the different syndrome of observation group is in table 5, and routine blood test and platelet change in table 6.
Table 3: before and after three groups of treatments, symptom integral compares
Table 4 three groups of comparitive study
The comparitive study of the different syndrome of table 5
Table 6: compare before and after three groups of hemogram treatments
Table 3-table 6 result prompting: the symptom integral for the treatment of before and after 1 group and treatment 2 groups treatment obviously reduces, and clinical cure rate and obvious effective rate generally improve, and compare with matched group, and treatment group has significant difference; And the curative effect for the treatment of 2 groups is better than treatment 1 group.Hematochrome, the platelet count for the treatment of group also present significant raising, also have significant difference than matched group.Result shows the present invention and compares with matched group, and the present invention all has good curative effect at the treatment syndrome of deficiency of QI of women, syndrome of deficiency of blood and deficiency of both QI and blood.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, and on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (8)
1. tonify deficiency urgees a Chinese medicine composition for breast, and it is characterized in that, this Chinese medicine composition is made up of the raw material of Chinese medicine of following weight portion: the Gallus Domesticus of unhairing, pawl and intestinal 180 ~ 220 parts, Radix Ginseng 22 ~ 35 parts, the Radix Astragali 35 ~ 50 parts, Arillus Longan 10 ~ 20 parts, Radix Angelicae Sinensis 15 ~ 30 parts.
2. Chinese medicine composition according to claim 1, is characterized in that being prepared from by following steps:
1) Gallus Domesticus stripping and slicing, decocts with water 2 ~ 3 times, each 1 ~ 3 hour, decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, let cool, add ethanol and make alcohol content reach 30 ~ 80%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, cold preservation, for subsequent use;
2) Radix Angelicae Sinensis, the Radix Astragali, Arillus Longan decoct with water 2 ~ 3 times, each 1 ~ 3 hour, and decocting liquid filters, filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, lets cool, adding ethanol makes alcohol content reach 30 ~ 80%, stir evenly, leave standstill, filter, filtrate recycling ethanol, when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, and cold preservation is for subsequent use;
3) distill after Radix Ginseng water retting, collect distillate, another device is preserved;
4) medicinal residues after the distillation of step 3) Radix Ginseng decoct with water 1 ~ 3 time, each 1 ~ 3 hour, and decocting liquid filters, and filtrate merges, and when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, leaves standstill, gets supernatant, for subsequent use;
5) get in step 4) remaining medicinal liquid after getting supernatant, add ethanol and make alcohol content reach 30 ~ 80%, stir evenly, leave standstill, get supernatant, reclaim ethanol, when being concentrated into 50 DEG C, relative density is 1.05 ~ 1.30, for subsequent use;
6) get step 1), 2), 4), 5) prepare the medicinal liquid for subsequent use of gained, after preparing with pharmaceutically acceptable carrier combination, add step 3) gained Radix Ginseng distillate, obtain Chinese medicine composition.
3. Chinese medicine composition according to claim 2, is characterized in that described step 1), 2), 5) in add ethanol, make alcohol content reach 70%.
4. Chinese medicine composition according to claim 2, is characterized in that method prepared by the pharmaceutically acceptable carrier combination of described step 6) is: after four kinds of medicinal liquids mixing for subsequent use, add Mel, sucrose and sorbic acid, mixing, heating makes dissolving, lets cool, filter, obtain filtrate.
5. Chinese medicine composition according to claim 2, is characterized in that the Gallus Domesticus active component in step 1) is prepared from by following methods: Gallus Domesticus stripping and slicing, decocts with water 1 ~ 3 hour, let cool to 40-60 DEG C, add protease, stir evenly, insulation 0.5-4 hour, get suspension, deactivation, filters, and when filtrate is concentrated into 50 DEG C, relative density is 1.10 ~ 1.30, cold preservation, for subsequent use.
6. Chinese medicine composition according to claim 5, is characterized in that letting cool temperature after described Gallus Domesticus decocts is 50 DEG C.
7. Chinese medicine composition according to claim 5, is characterized in that described protease is one or more in acid protease, neutral protease, alkaline protease, papain.
8. tonify deficiency urge breast a Chinese medicine composition oral liquid, by tonify deficiency according to claim 1 urge breast Chinese medicine composition and pharmaceutically acceptable carrier combination be prepared from.
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| CN108719832A (en) * | 2018-05-19 | 2018-11-02 | 广东威士雅保健品有限公司 | A kind of favour blood nutrient solution and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366517A (en) * | 2011-10-10 | 2012-03-07 | 邓华伦 | Chinese herbal medicine preparation for preventing and treating qi-blood weakness |
| CN103509705A (en) * | 2013-10-12 | 2014-01-15 | 陈友望 | Papaya wine formula |
| CN103784673A (en) * | 2012-12-17 | 2014-05-14 | 唐焱华 | Chinese herbal medicine for treating deficiency of qi and blood |
-
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102366517A (en) * | 2011-10-10 | 2012-03-07 | 邓华伦 | Chinese herbal medicine preparation for preventing and treating qi-blood weakness |
| CN103784673A (en) * | 2012-12-17 | 2014-05-14 | 唐焱华 | Chinese herbal medicine for treating deficiency of qi and blood |
| CN103509705A (en) * | 2013-10-12 | 2014-01-15 | 陈友望 | Papaya wine formula |
Non-Patent Citations (2)
| Title |
|---|
| 蔡慧珍编著: "《怀孕分娩坐月子专家指导》", 31 October 2012, 新世界出版社 * |
| 郑东旖主编: "《婴儿护理百科全书》", 30 June 2012, 吉林科学技术出版社 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108719832A (en) * | 2018-05-19 | 2018-11-02 | 广东威士雅保健品有限公司 | A kind of favour blood nutrient solution and preparation method thereof |
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