CN104013888A

CN104013888A - Traditional Chinese medicine composition for treating phlegm-heat lung-stagnation type obstructive emphysema and preparation method thereof

Info

Publication number: CN104013888A
Application number: CN201410307806.5A
Authority: CN
Inventors: 刘德学
Original assignee: Individual
Current assignee: Individual
Priority date: 2014-07-01
Filing date: 2014-07-01
Publication date: 2014-09-03

Abstract

The invention discloses a traditional Chinese medicine composition for treating phlegm-heat lung-stagnation type obstructive emphysema and a preparation method thereof. The traditional Chinese medicine composition comprises the following raw material medicines: thunberg fritillary bulb, caulis bambusae in taeniam, tabasheer, Platycodon grandiflorum, fructus perillae, the tuber of stemona, birthwort, flos farfarae, the root bark of white mulberry, Japanese Ardisia Herb, folium rhododendri daurici, Momordica grosvenori, rhizoma anemarrhenae, dayflower, Scutellaria baicalensis, Meadowrue Root and Rhizome, common andrographis Herb, Houttuynia cordata, lily, asparagus fern, Changium smyrnioides and rhizoma polygonati. The traditional Chinese medicine composition has the effects of clearing away the lung-heat and dissipating heat and calming the adverse-rising energy and relieving asthma and is mainly used for treating chronic phlegm-heat lung-stagnation symptoms of obstructive emphysema. By utilizing the theory of traditional Chinese medicine, the traditional Chinese medicine composition has the effects of regulating the disease resistance of the whole body, improving lung and bronchus tissue blood metabolism, enhancing the gas exchange efficiency, emphasizing on treatment based on syndrome differentiation in a targeted therapy manner, improving the diaphragm breath degree, promoting phlegm elimination, improving the respiratory muscle functions, keeping unobstructed airway and resisting infection.

Description

Chinese medicine composition for the treatment of type of phlegm-heat stagnating in the lung obstructive emphysema and preparation method thereof

Technical field

The present invention relates to contain the medicinal preparation that derives from plant, animal or raw mineral materials, particularly Chinese medicine composition for the treatment of type of phlegm-heat stagnating in the lung obstructive emphysema and preparation method thereof.

Background technology

Obstructive emphysema is chronic obstructive emphysema, and strictly speaking, emphysema are not independently diseases of one, but a dissection/structural term is the result of chronic bronchitis or other chronic Pulmonary Diseases development.Be mainly that the whole last bronchus distal portions of lung tissue comprises the expansion of respiratory bronchioles, alveolar duct, alveolar sac and alveolar and excessively inflation, cause lung tissue elastic force to go down, volume increases.Because its morbidity is slow, the course of disease is longer, therefore be called chronic obstructive emphysema.At the sickness rate of China between 0.6%～4.3%.

The cause of disease has following several: 1. smoking: cigarette contains multiple harmful components, as tar, nicotine and carbon monoxide etc.Smoker's mucous gland fucose and neuraminic acid content increase, and can suppress bronchial mucosa cilia activity, and reflexive causes bronchospasm, weaken the effect of pulmonary alveolar macrophage; 2. atmospheric pollution: autopsy proves, under weather and economic condition similar situation, the serious regional emphysema sickness rate of atmospheric pollution is height than polluting light area; 3. infect: Respirovirus and antibacterial infect with emophysematous certain relation.Repeated infection can cause bronchial mucosa hyperemia, edema, glandular hyperplasia, hypertrophy, and secretory function is hyperfunction, and tube wall thickens narrow, causes airway obstruction.When pulmonary infection, proteinase activity increases relevant with emphysema formation also possibility; 4. protease-protease inhibitor dysequilibrium: some proteolytic enzymes in body have Digestion to lung tissue, and protease inhibitor has inhibitory action for multiple protein enzymes such as elastases.The balance of protease and protease inhibitor is to maintain lung tissue normal configuration to avoid the key factor of destroying.The protease of digestion lung tissue has two kinds of sources, and exogenous from the pathogen such as antibacterial and mycete, endogenous is from neutrophilic granulocyte and pulmonary alveolar macrophage.Smoking increases elastase activity, and makes protease inhibitor inactivation.

Clinical manifestation: 1. symptom: the concealment of primary disease onset, taking chronic bronchitis as cause of disease person, has cough and expectoration history for many years.After smoker is everlasting and gets up morning, cough and cough mucus expectorant.When concurrent respiratory tract infection, expectorant is mucus purulence.How cough, expectoration symptom increase the weight of in the winter time, and alleviate gradually when weather turns warm next year.The cough of pathological changes severe patient, expectoration exist all the year round, without the rule of heavy light seasonal variety of summer of winter.Emphysema patient often has symptom out of breath, how in the time of movable Hou Rudeng building or power-walking, to feel out of breath in early days, also feels out of breath while developing into away level road later.If speaking, wear the clothes, wash one's face and even have when tranquillization out of breathly, prompting emphysema are quite serious.In addition still there is tired, poor appetite and the General Symptoms such as lose weight.Can there is corresponding symptom in acute attack stage Complicated With Respiratory Failure or right heart failure.Emphysema patient occurs having a headache and may point out CO2 retention, should further make arterial blood gas analysis.Hypoxemia person has cyanosis, also can secondary polycythemia.The clinical manifestation of obstructive emphysema can be divided into two types: (1) bronchitis type also claims the too fat to move type of cyanosis (BB type): bronchus pathological changes is heavier, mucosa swelling, and mucous gland hypertrophy, brokenk wind lightens micro-.Patient Chang You is smoking history and chronic cough, expectoration history for many years.Health check-up obesity, cyanosis, distension of jugular vein, edema of lower limbs, two bases of lung are heard and rale.C-XF checks pulmonary congestion, and increased bronchovascular shadows, has no obvious emphysema and levy.Pulmonary function test ventilatory function obvious damage, gas distribution is irregular, and FRA and total lung capacity increase, and diffusion is normal, and arterial partial pressure of oxygen reduces, and partial pressure of carbon dioxide raises, and packed cell volume increases, and easily develops into respiratory failure and (or) right heart failure.(2) emphysema type also claims without the dark purple type (PP type) of panting: emphysema are more serious, but bronchus pathological changes is not serious.Be more common in old age, body constitution is become thin, and dyspnea is obvious, without cyanosis.Patient often gets special attitude, as two shoulder heights alarm, both arms hold up bed, exhale time two cheeks heave and contracting lip.X-ray rabat two lung transparencys increase.Though ventilatory function also has infringement, be not as serious like that as bronchitis type, gas distribution is even, and residual gas accounts for total lung capacity ratio and increases, and alveolar ventilation normally even has hyperventilation, and therefore arterial partial pressure of oxygen reduces not obviously, and partial pressure of carbon dioxide is normal or reduce.2. check: 1. blood test: erythrocytosis can appear in some patients were, especially as PaO2<7.3kPa(55mmHg) time be obvious.How normal leukocyte is, while merging respiratory tract infection, can increase.2. blood gas analysis: because hypoxemia can appear in dysfunction of ventilation, PaO2 reduces.Though ventilation load increases, and by compensatory, PaCO2 is still maintained in normal range in early days.When the state of an illness further develops, the CO2 retention that can occur together, PaCO2 raises, and causes respiratory acidosis.3. x-ray inspection: thoracic expansion is full, lung volume increases, intercostal space broadening, rib is flat to be lifted.Lateral chest film is shown in the broadening of thorax anteroposterior diameter, and cardiac space increases.Diaphragm low level, diaphragm arched roof flattens.Lung field transmittance increases, visible limitation transmittance increases sometimes limitation emphysema or pulmonary belb.Lung field in addition pulmonary vascular markings reason very thin, sparse, straighten; And that interior band texture can increase is thick, disorderly.Heart is often vertical position, and podiod is long and narrow.The lower visible thorax of perspective and the moving degree of diaphram weaken.

Western medical treatment chronic obstructive emphysema should be used antibacterials, expectorant and bronchodilator as one sees fit.But the course for the treatment of is longer, widely apply for a long time antibiotic easily to produce drug resistance, untoward reaction is more, and the state of an illness is easily delayed, and clinical efficacy is not satisfactory, causes certain financial burden and stress to patient and family members, obviously reduces quality of life.

Chinese medicine thinks that chronic obstructive emphysema belongs to the categories such as motherland's medical science " pulmonary distension ", " the syndrome of dyspnea ".Pulmonary distension refers to that multiple chronic lung pattern disease shows effect repeatedly, protracted course of disease, and lung spleen kidney three deficiency of five ZANG-organs damage, thereby cause lung pipe unfavorable, deficient airway, lung qi is stopped up stagnant, it is pathological change that breast is born distension, and with the tachypnea of panting, cough is coughed up phlegm, chest is swollen full, uncomfortable in chest as plug, or cyanosis of the lips and nails, cardiopalmus edema, even there is stupor, the disease that collapse syndrome caused by dyspnea is Clinical symptoms.

Etiology and pathogenesis: the generation of primary disease, how because of the dificiency of the lung due to protracted disease, the retention of the expectorant stasis of blood, often lures this onste aggravation into because feeling again exopathogen.1. pneumonopathy delay pulmonary distension is more common in internal injury chronic cough, is breathed heavily for a long time, the lung such as heavys breathing, pulmonary tuberculosis is chronic disease for a long time, and delay is lost and controlled, and due to progressively developing, is that chronic pulmonary is a kind of home to return to of illness.Therefore, chronic pulmonary is the Basic disease cause that illness also just becomes pulmonary distension.2. six climate exopathogens are taken advantage of and are attacked that six climate exopathogens both can cause chronic cough, breathe heavily for a long time, the generation of the disease such as heavy breathing, fluid-retention in the chest and hypochondrium for a long time, can bring out again and increase the weight of these diseases, repeatedly take advantage of and attack, and they are delayed repeatedly difficult, cause the conversion of pathogenesis, are evolved into gradually pulmonary distension.Therefore being invaded by exogenous pathogen should be the cause of disease of pulmonary distension.3. though aged debility pulmonary distension patient is found in teenager, minority after all, and taking aged patient as many.Aged debility, lung kidney is all not enough, and it is that six climate exopathogens are taken advantage of the basis of attacking repeatedly that body void can not be defended outer, and vital QI cannot conquer pathogen after sense is evil and sick benefit is heavy is fallen ill repeatedly and just more empty, and circulation endlessly, impels pulmonary distension to form in this way.Pathological changes, first at lung, continues and affects spleen, kidney, and the later stage is sick and in the heart, liver.Because of lung governing qi, have one's ideas straightened out in nose, close fur outward, outside master meter is defended, therefore exopathogen from the invasion of mouth and nose, fur, every many attackings the lung first, cause lung qi a surname to fall unfavorable, superinverse and for coughing, abnormal ascending-descending of QI is for breathing heavily, the deficiency of the lung for a long time, main airway dysfunction is not normal.If pneumonopathy and spleen, child-organ disease involving its motherorgan, dysfunction of the spleen in transportation, can cause deficiency of both lung and spleen.The lung being the dominator of QI, the kidney being the root of QI, lung injures kidney, and kidney qi is feeble and exhausted, takes the photograph to receive and haves no right, and cannot not breathe hard continuously, and moving benefit is very.And the main water of kidney, decline of kidney-YANG, QI failing to transform into body fluid, pathogenic water overflows swollen, insults dyspnea and cough with palpitation of cardiopulmonary.Lung and heart pulse-phase are logical, and lung qi is assisted a ruler in governing a country heart operation blood vessels, and the deficiency of the lung is controlled joint dereliction of duty, and blood is not smooth, circulate unfavorable, blood stasis the lung pulse, lung qi is jammed more, causes blood stagnancy due to deficiency of QI, the stasis stagnation of QI, by the pernicious consequence of lung and the heart, the disease such as clinical visible cardiopalmus, cyanosis, edema, body of the tongue are dark violet.Heart-yang root is kidney-yang in the gate of vitality, and asthenia of renal yang further causes heart kidney yang to decline, and can present collapse syndrome caused by dyspnea danger and wait.Dialectical being divided into accordingly: 1, drink type in wind and cold: cough with dyspnea dyspnea with fullness of the chest must not crouch, and breathes hard out of breath, cough up phlegm white rare, show bubble, chest is swollen full, aversion to cold, aching of the whole body, or have not wish drink of xerostomia, and greenish complexion is dim, and corpulent tongue is large, dimly pale tongue, white and slippery fur, floating and tense pulse.2, type of phlegm-heat stagnating in the lung: cough with dyspnea and rough breath, expectorant is yellow or white, and thickness difficulty is coughed up, fullness in the chest agitation, order is swollen, and eyeball is prominent, or fever and sweating, or slight chill, yellow urine dry stool, thirst with desire to drink, dimly red tongue, yellow fur or yellow greasy, slippery and rapid pulse.3, retention of phlegm and blood stasis in the lung type: cough with copious phlegm, Se Bai or be foam, wheezing sound in the throat, failing to lie flat due to dyspnea, chest is swollen full, feels oppressed as plug, and complexion is greyish white and dark, cyanosis of the lips and nails, dark tongue quality or purple, Sublingual stasis of blood muscle increases slightly, greasy fur or turbid greasy, stringy and rolling pulse.4, type of mental confusion caused by phlegm: cough with dyspnea dyspnea with rapid and short breath day is heavy, and expectoration is not well, and apathetic expression is drowsiness, even haziness, delirium, dysphoria, becoming severe at night, stupor, floccitation and aimless action as if twisting thread appearing in the delirious patient, or limbs are tired moving, twitch, dimly red tongue or pale purple, or purple deep red, tongue is white greasy or yellow greasy, thready,rolling and rapid pulse.5, deficiency type of QI of the lung and kidney: superficial and short breath with difficulty to continue breathing, cough low voice timid, fullness in the chest is losed heart, very opening mouth and lifting shoulder due to dyspnea, resting on the bedstead to sleep can not be put down sleeping, cough, expectorant is as foam, and difficulty in expectorating, has palpitation, coldness of the body and sweating, dim complexion, light red tongue or dim purple, white and moist fur, deep,thready and forceless pulse.6, type of water overflowing caused by insuffi ciency of YANG: edema over the face, edeam of legs, even know all over the body swollen, gastral cavity painful abdominal mass abdominal distention, or abdominal distention has water, oliguria, cardiopalmus, breathes with cough that it is sleeping to put down, coughing up thin sputum: be afraid of cold, cyanosis on the face and lips, corpulent tongue with dark colour, white, slippery and moist fur, deep pulse imaginary number or knot generation.

Summary of the invention

Technical problem to be solved by this invention is, provides a kind of and had that lung heat clearing expels the heat-evil, effect of lowering the adverse QI to relieve asthma, cures mainly the Chinese medicine composition of chronic obstructive emphysema expectorant heat stagnation lung card.The present invention utilizes Traditional Chinese medical theory, by regulating the resistance against diseases of animal economy, improve lung and bronchial tissue's plasma metabolism, strengthen gas exchange efficiency, emphasize that determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs can immunotherapy targeted autoantibody, improve diaphram breathing degree, promote to eliminate the phlegm, improve respiratory muscle function, keep respiratory passage unblocked, infection; Meanwhile, selected natural Chinese medicines material, medicine source is extensive, and price is low, safe and effective, convenient drug administration, short treating period, patient is easy to accept, and can carry out clinical marketing.

In order to realize foregoing invention object, the invention provides a kind of Chinese medicine composition for the treatment of expectorant heat stagnation lung obstructive emphysema, wherein, described Chinese medicine composition comprises following raw medicinal material: Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, the Radix Stemonae, Fructus Aristolochiae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix Scutellariae, Radix et Rhizoma Thalictri, Herba Andrographis, Herba Houttuyniae, Bulbus Lilii, Radix Asparagi, Radix Changii and Rhizoma Polygonati.

Wherein, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: Bulbus Fritillariae Thunbergii 10-25 weight portion, Caulis Bambusae In Taenia 12-28 weight portion, Concretio Silicea Bambusae 10-25 weight portion, Radix Platycodonis 4-14 weight portion, Fructus Perillae 12-30 weight portion, Radix Stemonae 15-25 weight portion, Fructus Aristolochiae 5-12 weight portion, Flos Farfarae 14-27 weight portion, Cortex Mori 10-25 weight portion, Herba Ardisiae Japonicae 13-25 weight portion, Folium Rhododendri Daurici 10-26 weight portion, Fructus Momordicae 10-30 weight portion, Rhizoma Anemarrhenae 12-24 weight portion, Herba Commelinae 10-22 weight portion, Radix Scutellariae 10-20 weight portion, Radix et Rhizoma Thalictri 11-24 weight portion, Herba Andrographis 6-12 weight portion, Herba Houttuyniae 10-23 weight portion, Bulbus Lilii 15-30 weight portion, Radix Asparagi 10-26 weight portion, Radix Changii 10-25 weight portion and Rhizoma Polygonati 12-28 weight portion.

Wherein, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials can be: Bulbus Fritillariae Thunbergii 15-25 weight portion, Caulis Bambusae In Taenia 22-28 weight portion, Concretio Silicea Bambusae 20-25 weight portion, Radix Platycodonis 4-10 weight portion, Fructus Perillae 22-30 weight portion, Radix Stemonae 15-20 weight portion, Fructus Aristolochiae 5-10 weight portion, Flos Farfarae 14-17 weight portion, Cortex Mori 10-15 weight portion, Herba Ardisiae Japonicae 13-20 weight portion, Folium Rhododendri Daurici 15-26 weight portion, Fructus Momordicae 10-20 weight portion, Rhizoma Anemarrhenae 12-20 weight portion, Herba Commelinae 15-22 weight portion, Radix Scutellariae 15-20 weight portion, Radix et Rhizoma Thalictri 11-20 weight portion, Herba Andrographis 9-12 weight portion, Herba Houttuyniae 10-15 weight portion, Bulbus Lilii 25-30 weight portion, Radix Asparagi 10-16 weight portion, Radix Changii 10-15 weight portion and Rhizoma Polygonati 22-28 weight portion.

Wherein, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials can be: Bulbus Fritillariae Thunbergii 25 weight portions, Caulis Bambusae In Taenia 28 weight portions, Concretio Silicea Bambusae 25 weight portions, Radix Platycodonis 4 weight portions, Fructus Perillae 12 weight portions, the Radix Stemonae 25 weight portions, Fructus Aristolochiae 5 weight portions, Flos Farfarae 27 weight portions, Cortex Mori 25 weight portions, Herba Ardisiae Japonicae 25 weight portions, Folium Rhododendri Daurici 26 weight portions, Fructus Momordicae 30 weight portions, the Rhizoma Anemarrhenae 24 weight portions, Herba Commelinae 22 weight portions, Radix Scutellariae 20 weight portions, Radix et Rhizoma Thalictri 24 weight portions, Herba Andrographis 12 weight portions, Herba Houttuyniae 23 weight portions, Bulbus Lilii 30 weight portions, Radix Asparagi 26 weight portions, Radix Changii 25 weight portions and Rhizoma Polygonati 28 weight portions.

Wherein, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials can also be: Bulbus Fritillariae Thunbergii 15 weight portions, Caulis Bambusae In Taenia 22 weight portions, Concretio Silicea Bambusae 20 weight portions, Radix Platycodonis 4 weight portions, Fructus Perillae 22 weight portions, the Radix Stemonae 20 weight portions, Fructus Aristolochiae 10 weight portions, Flos Farfarae 17 weight portions, Cortex Mori 15 weight portions, Herba Ardisiae Japonicae 20 weight portions, Folium Rhododendri Daurici 26 weight portions, Fructus Momordicae 20 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Herba Commelinae 15 weight portions, Radix Scutellariae 15 weight portions, Radix et Rhizoma Thalictri 11 weight portions, Herba Andrographis 9 weight portions, Herba Houttuyniae 10 weight portions, Bulbus Lilii 25 weight portions, Radix Asparagi 16 weight portions, Radix Changii 15 weight portions and Rhizoma Polygonati 28 weight portions.

Wherein, when the dosage form of described Chinese medicine composition is spray, its preparation method is:

A, get the water that the described raw medicinal material Radix Stemonae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix et Rhizoma Thalictri, Herba Houttuyniae, Bulbus Lilii and Rhizoma Polygonati add 1-3 doubly to measure, heating extraction 2 times, each 30-45 minute that extracts, 2 extracting solution are merged and left standstill, filter the extractum 1 that when concentrating under reduced pressure is 75-85 DEG C, relative density is 1.01-1.03;

B, the medicinal residues that described step a is obtained and remain described raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii and add the 68-84% soak with ethanol 25-30 minute that 1-3 doubly measures, extract twice, each 30-45 minute, merge extractive liquid,, filter through 90-130 order, 7200-9000 rev/min after centrifugal supernatant, be the ultrafiltration post ultrafiltration of 4100-6900 through the molecular weight that dams, the extractum 2 that when ultrafiltrate concentrating under reduced pressure is 80-90 DEG C, relative density is 1.02-1.06;

C, described extractum 1 and described extractum 2 are mixed, add with respect to mixing extractum quality 2-3 deionized water doubly, be mixed into spray.

Wherein, when the dosage form of described Chinese medicine composition is honey refining pill, its preparation method is:

A, first the raw medicinal material Radix Stemonae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix et Rhizoma Thalictri, Herba Houttuyniae, Bulbus Lilii and Rhizoma Polygonati distillation crystal powder are broken into powder;

B, get 80-94% soak with ethanol 1-3 hour, heating extraction 1-2 time that residue described raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii add 2-4 doubly to measure, each 1-3 hour, filter to obtain extracting solution, merge extractive liquid,, be the ultrafiltration post ultrafiltration of 38000-84000 again through the molecular weight that dams, ethanol is removed in ultrafiltration decompression, the extractum that simmer down to 80-90 DEG C time, relative density is 1.02-1.04, becomes component 1;

The medicinal residues that c, step b obtain add 2-4 times of water gaging and soak 1.0-2.0 hour, within 1.0-1.5 hour, extract 1 time, and the extractum that during by 80-90 DEG C of extracting solution decompression heating simmer down to, relative density is 1.03-1.08, as component 2;

D, component 1, component 2 are mixed with the powder that step a obtains, add the Mel of doubly measuring with respect to mixture 1-2 to be twisted into honey refining pill.

Wherein, the dosage form of described Chinese medicine composition is when sucking agent, and its preparation method is:

The first step: by the described raw medicinal material Radix Stemonae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix et Rhizoma Thalictri, Herba Houttuyniae, Bulbus Lilii and Rhizoma Polygonati extraction by steam distillation, obtain crystal and sucking filtration liquid, sucking filtration liquid is concentrated that water extraction liquid a, crystal obtain alcohol liquid b through the dissolve with ethanol of 82%-89%;

Second step: decoct with water twice after described residue raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii are mixed, add for the first time the water that 3-4 doubly measures, decoct 1-3 hour, extract decoction liquor; The water that 2-3 doubly measures for the second time, decocts 30-45 minute, extracts decoction liquor, decoction liquor is merged, then reduce pressure thin film concentration during to 60-70 DEG C relative density be 1.24-1.45, the ethanol of the 82-89% doubly measuring with 1-3 leaves standstill 5-8 hour precipitation, precipitate with ethanol obtains supernatant c;

The 3rd step: described supernatant c, described water extraction liquid a and described alcohol liquid b are merged, the decompression thin film concentration concentrated solution that relative density is 1.06-1.10 during to 50-60 DEG C, add again the metronidazole of doubly measuring with respect to described concentrated solution 0.002-0.005, add water dilution, subpackage that 1-3 doubly measures, get final product to such an extent that suck agent.

Described Chinese medicine composition, medicine is decocted in use decoction and is taken, and 1 dose of every day, decocting takes at twice, and every 7 days is a course for the treatment of; In the time that this Chinese medicine composition is the use of honey refining pill, 2 times on the one, every 7 days is a course for the treatment of; When this Chinese medicine composition be spray, suck agent use time, 4-5 time on the one, every 7 days is a course for the treatment of.

The dosage form of described Chinese medicine composition is: tablet, enteric coated tablet, sugar coated tablet, capsule, hard capsule, oral liquid, suck agent, soft capsule, spray, film coated tablet, electuary, honey refining pill, powder, granule, sublimed preparation, solution, injection, suppository, plaster, syrup and powder.

The beneficial effect that technical scheme of the present invention is brought is: the present invention has lung heat clearing and expels the heat-evil, effect of lowering the adverse QI to relieve asthma, treatment obstructive emphysema expectorant heat stagnation lung card.The present invention utilizes Traditional Chinese medical theory, by regulating the resistance against diseases of animal economy, improve lung and bronchial tissue's plasma metabolism, strengthen gas exchange efficiency, emphasize that determination for the treatment of based on pathogenesis obtained through differentiation of symptoms and signs can immunotherapy targeted autoantibody, improve diaphram breathing degree, promote to eliminate the phlegm, improve respiratory muscle function, keep respiratory passage unblocked, infection; Meanwhile, selected natural Chinese medicines material, medicine source is extensive, and price is low, safe and effective, convenient drug administration, short treating period, good effect, avirulence.

Detailed description of the invention

Chinese medicine thinks, chronic obstructive emphysema pathological factor has that expectorant is turbid, diseases caused by retention of fluid, blood stasis, the deficiency of vital energy, the stagnation of QI, and they affect each other, doublely sees with sick.Type of phlegm-heat stagnating in the lung is usually expressed as: cough with dyspnea and rough breath, and expectorant is yellow or white, and thickness difficulty is coughed up, fullness in the chest agitation, order is swollen, and eyeball is prominent, or fever and sweating, or slight chill, yellow urine dry stool, thirst with desire to drink, dimly red tongue, yellow fur or yellow greasy, slippery and rapid pulse.According to traditional Chinese medical science judgement, lung heat clearing expels the heat-evil, and lowering the adverse QI to relieve asthma is the Therapeutic Principle of primary disease.

Therefore, the invention provides a kind of Chinese medicine composition for the treatment of type of phlegm-heat stagnating in the lung obstructive emphysema, it expels the heat-evil with lung heat clearing, lowering the adverse QI to relieve asthma is primary treatment principle, selects following raw medicinal material: Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, the Radix Stemonae, Fructus Aristolochiae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix Scutellariae, Radix et Rhizoma Thalictri, Herba Andrographis, Herba Houttuyniae, Bulbus Lilii, Radix Asparagi, Radix Changii and Rhizoma Polygonati.

Wherein, Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis Qinghua heat-phlegm; Fructus Perillae, the Radix Stemonae, Fructus Aristolochiae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae clearing heat and purging lung, relieving cough and asthma; The Rhizoma Anemarrhenae, Herba Commelinae, Radix Scutellariae, Radix et Rhizoma Thalictri, Herba Andrographis, Herba Houttuyniae clearing away heat-fire, removing toxic substances; Bulbus Lilii, Radix Asparagi, Radix Changii, Rhizoma Polygonati boosting qi and nourishing yin, the lung moistening and production of body fluid promoting.Full side's compatibility is rigorous, can improve diaphram breathing degree, promotes to eliminate the phlegm, and improves respiratory muscle function, keeps respiratory passage unblocked, infection etc.

Now the pharmacology situation of each taste raw medicinal material is described below:

Bulbus Fritillariae Thunbergii: the large hardship of taste, cold in nature; Enter lung, the heart, stomach, Liver Channel." book on Chinese herbal medicine is just ": " great order lung abscess lung withers, and cough with asthma is spitted blood, and mental disorder, falls most in epistaxis, kind relieving stagnation, the pain that relieves the pain, relieving distension is full, clearing away liver-fire, improve visual and auditory acuity, except seasonal epidemic pathogens dysphoria with smothery sensation, jaundice stranguria with urinary obstruction, the hematuria of having blood in stool; Relieving heat toxin, kills parasites and treats sore throat, scrofula, and acute mastitis carbuncle on the back, all carbuncle and ulcer toxic swellings, damp and hot malignant boil, anal fistula, incised wound is hemorrhage, burn pain, than Bulbus Fritillariae Cirrhosae, the merit of falling clearly, not less than several times." " Shandong Chinese herbal medicine handbook ": " removing heat from the lung and dissipating phlegm, antacid, removing toxic substances." " Sheng Nong's herbal classic is met former ": " a kind of large and bitter person only can detoxify for Bulbus Fritillariae Uninbracteatae, river person's sweet in the mouth the best: western thin taking second place of person's taste, the micro-hardship of Xiangshan person is taken second place again.And go the heart to use.All lung meridian medicines all ought remove the heart, and not only Bulbus Fritillariae Uninbracteatae also." removing heat-phlegm, powder detoxifcation.With controlling cough due to pathogenic wind-heat, lung abscess sore throat, scrofula, sore swollen toxin.Antitussive peimine and peiminine have antitussive effect. and spasmolytic Bulbus Fritillariae Uninbracteatae alkaloid has atropine-like effect, low concentration can make tracheal smooth muscle lax, and high concentration can make tracheal smooth muscle slight shrinkage. and effect peimine and peiminine to central nervous system have calmness and analgesic activity.

Caulis Bambusae In Taenia: cold nature, sweet in the mouth; Enter lung, stomach warp." book on Chinese herbal medicine is new again ": " pathogenic fire purging relieving restlessness, lung moistening dissipating depression of QI, the removing heat from blood that reduces phlegm, emesis blood, Removing Blood Stasis, eliminating carbuncle flaccidity toxic swelling." " detailed outline ": " the cold recurrence caused by overexertion that cures the wound, little Re Epilepsy, married woman's fetal movement." " book on Chinese herbal medicine is just ": " and control consumptive lung disease saliva expectorant, hematuria, married woman's heat in blood collapses pouring, fetal movement, and children's wind-heat epilepsy, mental disorder is breathed with cough, and little hydro-thermal is puckery." function removing heat-phlegm, relieve restlessness and prevent vomiting.Hold expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, wind-phlegm fan, aphasia with stiff tongue, gastropyretic vomiting, pregnancy reactions, frequent fetal movement under the arm for phlegm-heat cough, gallbladder fire.Being slightly cold property of Caulis Bambusae In Taenia sweet in the mouth profit.

Concretio Silicea Bambusae: sweet, cold; Enter the heart, liver, lung meridian." Japan hanako materia medica ": " control middle wind-phlegm and stop up, acute aphasia in silence, convulsive seizure induced by terror in children and epilepsy expectorant." " Kaibao Bencao ": " main infantile convulsion sky hangs, and relieving palpitation improving eyesight, goes all wind heat, treats incised wound hemostasis, nourishes the five internal organs." function clear heat and eliminate phlegm, cool heart arresting convulsion.Cure mainly calentura coma delirium, middle wind-phlegm fan in silence, twitch, epilepsy, phlegm-heat cough by infantile convulsion.

Radix Platycodonis: bitter in the mouth, pungent, property is flat.Return lung meridian.There is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus, sharp the five internal organs, effect of filling blood, mend five kinds of over strain, fostering the spirit of nobility.Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess vomiting pus, fullness in the chest and hypochondriac pain, dysentery stomachache, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, uroschesis.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus." herbal classic " said: " main chest and hypochondrium is as lancination, abdominal distention, borborygmus are faint, the gas of throbbing with fear in terror "." Japan hanako materia medica " said: " trusted subordinate's distending pain, mends five kinds of over strain, fosters the spirit of nobility for lower all gas, only cramp caused by acute vomiting and diarrhea, and evil removing is warded off temperature, tonify deficiency expectorant, and broken lump in the abdomen, the evacuation of pus of nourishing blood, mends internal hemorrhage due to trauma and sore throat ".Modern pharmacological research shows, Radix Platycodonis has and eliminates the phlegm and antitussive effect; Hypoglycemic activity; Suppress gastric secretion and antiulcer action; Antiinflammatory action; Calmness, analgesia and refrigeration function.

Fructus Perillae: pungent, temperature.Return lung, spleen channel.Can relieving the exterior syndrome by diaphoresis, regulating the flow of QI to ease the stomach, solving toxin of fish and crab.For anemofrigid cold, headache, cough, distension and fullness of the chest and abdomen, fish Eriocheir sinensis is poisoning.Folium Perillae acrid in the mouth warm in nature, have induce sweat, cold expelling, the effect of regulating the flow of vital energy and seeking.Be applicable to the diseases such as cold, fever with aversion to cold, cough, asthma, distension and fullness of the chest and abdomen.Folium Perillae Herb all has very high nutritive value, and it has low sugar, high fiber, high carotene, high mineral element etc.In volatile oil, contain perillaldehyde, perilla alcohol, menthone, menthol, eugenol, ergomaketon etc.Defying age element SOD in every milligram of Folium Perillae content up to 106.2 micrograms.Find after deliberation, the each position of Folium Perillae evenly has good antitumaous effect, especially stronger with the effect in blade, oleanolic acid is wherein a kind of very strong natural anti-cancer agent, there is the effect of prophylaxis of tumours, there is again the effect of antiinflammatory, calmness, heart tonifying, diuresis, enhancing immunity, blood fat reducing and resistance growth of cancer cells.Folium Perillae can diaphoresis cold expelling to separate pathogenic factor in the exterior, again can promoting the circulation of QI to alleviate the stagnation in middle-JIAO, resolving depression preventing or arresting vomiting, therefore wind and cold table disease is doublely seen to symptoms of emesis uncomfortable in chest, use this product, be very suitable; Or have the stagnation of QI not smooth symptom without table disease, also can be used for a surname logical.

The Radix Stemonae: nature and flavor are sweet, bitter, tepor.Return lung meridian." the southern regions of the Yunnan Province book on Chinese herbal medicine " records it: " lung moistening, controls cough due to lung-heat; Sputum eliminating to stop asthma, only chronic consumptive disease cough, parasite killing ".There is nourishing the lung to arrest cough, effect of parasite killing delousing.Main new chronic cough is coughed, pulmonary tuberculosis, pertussis, enterobiasis, body louse, tinea scabies.Can nourishing the lung to keep the adverse QI downward cough-relieving, parasite killing.Cough for new chronic cough, pulmonary tuberculosis cough, pertussis; Outward for head louse, body louse, enterobiasis, pudendum Pruritus.Honey Radix Stemonae nourishing the lung to arrest cough.For deficiency of YIN chronic cough.

Fructus Aristolochiae: bitter in the mouth, cold nature, returns lung, large intestine channel, has lung heat clearing sending down the abnormal ascending QI, relieving cough and asthma, disappear effect of hemorrhoid of bowel relieving, for dyspnea and cough due to lung-heat, sputum mixed with blood, the hot hemorrhoidal bleeding of intestinal, the cards such as swelling and pain of hemorrhoid.Fructus Aristolochiae has gentleness and lasting hypotensive effect.

Flos Farfarae: acrid in the mouth, warm in nature; Return lung meridian." Japan hanako materia medica ": " profit cardiopulmonary, beneficial the five internal organs, relieving restlessness, benefit labor is bad, stopping coughing and removing phlegm, pulmonary fistula is spitted blood, and the palpitation with fear of having a guilty conscience, washes liver improving eyesight and apoplexy." " book on Chinese herbal medicine take advantage of refined half brave ": " and Flos Farfarae is with controlling cough with dyspnea, kind breathing heavily, sore throat, and because kidney is bitter dry and cold physique drink is cold, being attacked by pathogenic dampness in autumn person is begun suitable.Or burning hot punishment gold, or withering lung lobes with stuffy lung-QI, probably benefit disappears to sparkle and injures." preventing phlegm from forming and stopping coughing.There is the antitussive therapeutic method to keep the adverse QI flowing downwards, the function that lung moistening is eliminated the phlegm.For cough, asthma, consumptive lung disease, coughs the diseases such as blood of spitting.Flower is containing sterols, globulariacitrin, hyperin, triterpenoid saponin, tannin, wax, volatile oil and taraxanthins such as faradiols.Leaf is containing bitterness glycoside 2.63%, gallic acid, gum elastic sample material, dextrin, mucus, inulin, plant sterol, stearic acid and tripalmitin, tartaric acid, malic acid, Nulomoline, choline, Hydrocarbon and Saponin.Collective Notes to the Canon of Materia medica: " Semen Armeniacae Amarum is for making.Obtain Radix Asteris good.Dislike Fructus Gleditsia, Sal Nitri, Radix Scrophulariae.Fear Bulbus Fritillariae Uninbracteatae, Flos Magnoliae, Herba Ephedrae, Radix Scutellariae, Rhizoma Coptidis, Radix Astragali, Herba Celosiae argenteae.”

Cortex Mori: Gan Han, enters lung meridian.Shennong's Herbal: " sweet in the mouth, cold.Cure mainly damaging the spleen and stomach, five kinds of over strain, six types of severe debility disease, weakness and emaciation, metrorrhagia, pulse disappeared, tonify deficiency, QI invigorating.Leaf: main except cold and heat, perspire." " Mingyi Bielu ": " nontoxic.Main go aqueous vapor in lung, only hemoptysis, heat is thirsty, edema, abdominal distention, sets out swollenly, and dredging water passages, goes cun whitely, can stitch gold wound." " Japan hanako materia medica ": " and temperature, in tune, the therapeutic method to keep the adverse QI flowing downwards.Expectorant is quenched the thirst, sharp intestine and small intestine, and appetizing, lower food, kills abdomen and hides worm, and only cholera is vomited and diarrhoea." function eliminating pathogen from the lung for relieving asthma, inducing diuresis to remove edema.For lung-heat cough with asthma, the edema of the face, the diseases such as dysuria.

Herba Ardisiae Japonicae: property is flat, acrid in the mouth, micro-hardship; Return lung, Liver Channel.Supplementary Amplifications of the Compendium of Materia Medica: " control haematemesis impairment caused by overstrain, timid disease is critically ill, and chronic cough becomes labor." " Zhiwu Mingshi Tukao ": " control toxic swelling, dysentery, antidotes against snake bite, and rescues heatstroke." " Chinese herbal medicine is commonly used in Shanghai ": " promoting blood circulation and stopping pain, diuresis, stomach invigorating, hemostasis.Control jaundice due to damp-heat, hepatitis, acute nephritis, cystitis, pulmonary tuberculosis night sweat, spitting of blood, de-power impairment caused by overstrain, muscles and bones is ached, menoxenia, nasal sinusitis." property is flat cooler, expelling phlegm for arresting cough antiasthmatic effect is more obvious, and cough with asthma has expectorant and to belong to hot person particularly suitable.Again can eliminating damp-heat, blood circulation promoting and blood stasis dispelling, also can be with controlling jaundice due to damp-heat, edema, and amenorrhea dysmenorrhea, rheumatic arthralgia, the cards such as traumatic injury.

Folium Rhododendri Daurici: pungent, bitter, cold in nature; Enter lung meridian.Cough suppressing effect is showing, and eliminates the phlegm and takes second place, and relievings asthma poor, and antiinflammation is not strong, can not preventing cold.

Fructus Momordicae: cool in nature, sweet in the mouth.Return lung, large intestine channel.Clearing heat and moistening lung, cough-relieving, sore-throat relieving, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.

The Rhizoma Anemarrhenae: bitter in the mouth, sweet, cold in nature, enter lung, stomach, kidney channel, there is the relieving restlessness of purging heat, the effect of nourshing Yin and drynsessmoistening prescription, clearing away lung-heat to relieve cough, cures mainly fever caused by exogenous pathogenic factors, and high heat is irritated, lung-heat type cough, the interior-heat symptom such as quench one's thirst; Its bitter cold matter profit, property sedimentation, can heat clearing away, can promote the production of body fluid again, kindly controls warm pathogenic factor and enters edema caused by disorder of QI, intenseness of heat impairment of body fluid; Also be used for the treatment of diabetes; Phlegm-heat obstructing in the lung and breathing heavily, xeropulmonary cough, expectorant is few unfavorable; Hyperactivity of fire caused by deficiency of YIN, the symptoms such as hyperactivity of deficient fire.

Herba Commelinae: sweet, cold, light; Enter the heart, liver,spleen,kidney, all warps of intestine and small intestine.Supplement to the Herbal: " fourth is swollen for main cold and heat subtertian malaria, phlegm retention, and meat disease is not smooth, infantile erysipelas, and the mad epilepsy of generating heat, large abdomen feeling of fullness, body face edema due to disorder of QI, hematodiarrhoea, Serpentis dog stings, the poison such as carbuncle." " the southern regions of the Yunnan Province book on Chinese herbal medicine ": " invigorating QI and blood, treats married woman leucorrhea, red collapsing, tissue regeneration promoting blood, only hematuria, epistaxis blood, stranguria with blood." for fever caused by exogenous pathogens, or febrile disease heating do not move back, or laryngopharynx swelling and pain, and the disease such as carbuncle skin infection.For dysuria, edema, or wet into diseases such as bet bladder, the puckery pains of dribbling urination.

Radix Scutellariae: property hardship, cold.Return lung, gallbladder, spleen, large intestine, small intestine meridian." book on Chinese herbal medicine converges and says ": " clear flesh is brought down a fever, and Radix Bupleuri the best, so can not reach table by cool flesh without Radix Scutellariae.The fire of the part of the body cavity above the diaphragm housing the heart and lungs, mountain mast can fall, and so gives up Radix Scutellariae and can not go up refresh oneself.So Fang Mai section with clear flesh bring down a fever, speciality of carbuncle and ulcers with removing toxic substances and promoting granulation, bright section with heat radiation improving eyesight, women section is with it antiabortive reason warp, agent also first of Ci Gaizhu section half exterior and half interior." can heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood is told nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.That Radix Scutellariae has is antipyretic, calm, blood pressure lowering, diuresis, reduction capillary permeability, suppress the effects such as intestinal tube wriggling, staphylococcus, blood dissolubility streptococcus, Diplococcus pneumoniae, Bacillus typhi, dysentery coccus, newcastle, bacillus pyocyaneus are had to certain inhibitory action, upper respiratory tract infection, chronic bronchitis, bacillary dysentery etc. are had to good curative effect.

Radix et Rhizoma Thalictri: nature and flavor bitter cold, heat clearing and damp drying, eliminating fire and detoxication.Control damp-heat dysentery, jaundice, calentura agitation, cough due to lung-heat, carbuncle pyogenic infections from tumour or sore, conjunctival congestion and swelling pain.Be applied to now enteritis, infectious hepatitis, flu, measles, carbuncle furuncle, conjunctivitis.

Herba Andrographis: have heat-clearing and toxic substances removing, antiinflammatory, reducing swelling and alleviating pain effect.Cure mainly bacillary dysentery, urinary tract infection, acute tonsillitis, enteritis, pharyngolaryngitis, pneumonia and influenza etc.Herba Andrographis has eliminating inflammation and expelling toxin effect, once be applied to clinically multi-infection disease, comprise trauma infection contamination, furuncle, carbuncle, erysipelas, upper respiratory tract infection, acute and chronic tonsillitis, acute and chronic pharyngitis, acute/chronic bronchitis, acute bacillary dysentery, acute gastroenteritis, urinary tract infection, endometritis, pelvic inflammatory disease, otitis media, periodontitis etc., all have curative effect in various degree.

Herba Houttuyniae: cold nature, bitter in the mouth.Return lung meridian, bladder, large intestine channel.There is heat-clearing and toxic substances removing; Removing pus and relieving carbuncle; The function of inducing diuresis for treating stranguria syndrome.Cure mainly the main lung abscess vomiting pus of pyretic stranguria; Expectorant dyspnea of heat type is coughed; Larynx; Hematodiarrhoea; Carbuncle sore tumefacting virus; Pyretic stranguria.Effect: heat-clearing and toxic substances removing, inducing diuresis to remove edema.Control pneumonia, lung abscess, hematodiarrhoea, malaria, edema, gonorrhea, leucorrhea, carbuncle, hemorrhoid, proctoptosis, eczema, tinea alba, scabies.The modern multiplex lung abscess of controlling, pneumonia, acute and chronic tracheitis, urinary tract infection etc.

Bulbus Lilii: Bulbus Lilii is except containing protein 21.29%, fat 12.43%, reducing sugar 11.47%, starch 1.61%, and calcium, phosphorus, ferrum, every hectogram are containing outside the nutrients such as 1.443 milligrams of vitamin Bs, 21.2 milligrams of vitamin Cs, also contain some special nutritional labelings, as multiple alkaloids such as colchicine.These composition comprehensive functions, in human body, not only have the merit of good nutritious tonifying, but also multiple Seasonal diseases dry in autumn and that cause is had to certain preventive and therapeutic effect.In the traditional Chinese medical science, say that fresh Bulbus Lilii has tranquilizing by nourishing the heart, effect of nourishing the lung to arrest cough, is highly profitable to weakling after being ill.

Radix Asparagi: cold in nature, sweet and slightly bitter taste; Enter liver, lung, kidney channel." property of medicine opinion ": " main lung qi cough with dyspnea, pants short anxious, heat extraction, and logical kidney qi, treats the raw carbuncle vomiting pus of consumptive lung disease, controls scabies humida, only quench one's thirst, the apoplexy of reducing phlegm and internal heat, for a long time clothes." " Japan hanako materia medica ": " and relieving palpitation, moistening five ZANG-organs, beneficial skin, improving healthy complexion, mends five kinds of strain and seven kinds of impairment, controls lung qi and coughs, expectorant, migratory arthralgia pyretic toxicity, urticaria, unhappy haematemesis." to general optimum mammary neoplasms, especially breast lobule hyperplasia, no matter lump size is proved effective rapidly, great majority can obtain healing.Have and calm the nerves, nourish heart, lung moistening, tonification, nourishing kidney, the curative effects such as blood pressure lowering and loosening bowel to relieve constipation.Decoct in vitro tests all has bacteriostasis in various degree to anthrax bacillus, A type and beta hemolytic streptococcus, diphtheria corynebacterium, diphtheroid, Diplococcus pneumoniae, staphylococcus aureus, Staphylococcus citreus, Staphylococcus albus and bacillus subtilis.

Radix Changii: sweet in the mouth, micro-hardship, cold nature, returns lung, spleen, Liver Channel, " Bencao Congxin ": " tonifying the lung gas, logical, descending, tonifying QI to produce body fluid.Control cough dyspnea, expectorant is stopped up fire and is risen, and chronic malaria is drenched drop, difficult labour, and amenorrhea, dysentery is due to lung-heat, and regurgitation is dysphagic due to dry puckery." there is moistening the lung and resolving phlegm, yin nourishing stomach function regulating, effect of suppressing the hyperactive liver removing toxic substances, for cough due to lung-heat, vomiting regurgitation, lack of appetite xerostomia, the card such as conjunctival congestion is dizzy, furunculosis skin infection.

Rhizoma Polygonati: sweet in the mouth, property is flat, enters lung, spleen, kidney channel, there is the yin nourishing of fostering the spirit of nobility, spleen invigorating lung moistening, effect of enriching kidney essence, for taste deficiency of qi and yin, lack of appetite is unable, lung-dryness syndrome due to deficiency of YIN, the few expectorant of dry cough, dry cough expectorant is few, the polydipsia of quenching one's thirst, weakness of the spleen and stomach, deficiency of spleen-QI or deficiency of spleen-YIN, the quenching one's thirst of yin asthenia generating intrinsic heat, the cards such as deficiency of kidney essence, impotence and seminal emission, dizziness and tinnitus, blurred vision dim eyesight.

A, first the described raw medicinal material Radix Stemonae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix et Rhizoma Thalictri, Herba Houttuyniae, Bulbus Lilii and Rhizoma Polygonati distillation crystal powder are broken into powder;

C, the medicinal residues that step b is obtained add 2-4 times of water gaging and soak 1.0-2.0 hour, within 1.0-1.5 hour, extract 1 time, and the extractum that during by 80-90 DEG C of extracting solution decompression heating simmer down to, relative density is 1.03-1.08, as component 2;

Second step: decoct with water twice after described raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii are mixed, add for the first time the water that 3-4 doubly measures, decoct 1-3 hour, extract decoction liquor; The water that 2-3 doubly measures for the second time, decocts 30-45 minute, extracts decoction liquor, decoction liquor is merged, then reduce pressure thin film concentration during to 60-70 DEG C relative density be 1.24-1.45, the ethanol of the 82-89% doubly measuring with 1-3 leaves standstill 5-8 hour precipitation, precipitate with ethanol obtains supernatant c;

Below adopt embodiment to describe embodiments of the present invention in detail, to the present invention, how application technology means solve technical problem whereby, and the implementation procedure of reaching technique effect can fully understand and implement according to this.

Embodiment 1 spray

Bulbus Fritillariae Thunbergii 250g, Caulis Bambusae In Taenia 280g, Concretio Silicea Bambusae 250g, Radix Platycodonis 140g, Fructus Perillae 300g, Radix Stemonae 250g, Fructus Aristolochiae 120g, Flos Farfarae 270g, Cortex Mori 250g, Herba Ardisiae Japonicae 250g, Folium Rhododendri Daurici 260g, Fructus Momordicae 300g, Rhizoma Anemarrhenae 240g, Herba Commelinae 220g, Radix Scutellariae 200g, Radix et Rhizoma Thalictri 240g, Herba Andrographis 120g, Herba Houttuyniae 230g, Bulbus Lilii 300g, Radix Asparagi 260g, Radix Changii 250g and Rhizoma Polygonati 280g.

Its preparation process is:

A, get the water that the described raw medicinal material Radix Stemonae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix et Rhizoma Thalictri, Herba Houttuyniae, Bulbus Lilii and Rhizoma Polygonati add 3 times of amounts, heating extraction 2 times, each extraction 45 minutes, 2 extracting solution are merged and left standstill, filter the extractum 1 that when concentrating under reduced pressure is 85 DEG C, relative density is 1.03;

B, the medicinal residues that described step a is obtained and remain 84% soak with ethanol 30 minutes that described raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii add 3 times of amounts, extract twice, each 45 minutes, merge extractive liquid,, filter 7200 revs/min of supernatant after centrifugal through 130 orders, be 4100 ultrafiltration post ultrafiltration through the molecular weight that dams, the extractum 2 that when ultrafiltrate concentrating under reduced pressure is 80 DEG C, relative density is 1.02;

C, described extractum 1 and described extractum 2 are mixed, add with respect to the deionized water that mixes 2 times of extractum quality, be mixed into spray.

Embodiment 2 honey refining pills

Bulbus Fritillariae Thunbergii 150g, Caulis Bambusae In Taenia 220g, Concretio Silicea Bambusae 200g, Radix Platycodonis 40g, Fructus Perillae 220g, Radix Stemonae 150g, Fructus Aristolochiae 50g, Flos Farfarae 140g, Cortex Mori 100g, Herba Ardisiae Japonicae 130g, Folium Rhododendri Daurici 150g, Fructus Momordicae 100g, Rhizoma Anemarrhenae 12-20g, Herba Commelinae 150g, Radix Scutellariae 150g, Radix et Rhizoma Thalictri 110g, Herba Andrographis 90g, Herba Houttuyniae 100g, Bulbus Lilii 250g, Radix Asparagi 100g, Radix Changii 100g and Rhizoma Polygonati 220g.

Its preparation process is:

B, get 84% soak with ethanol 3 hours, heating extraction 2 times that residue described raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii add 2 times of amounts, each 1 hour, filter to obtain extracting solution, merge extractive liquid,, be 84000 ultrafiltration post ultrafiltration again through the molecular weight that dams, ethanol is removed in ultrafiltration decompression, the extractum that when 80 DEG C of simmer down tos, relative density is 1.02, becomes component 1;

The medicinal residues that c, step b obtain add 2 times of water gagings and soak 1.0 hours, within 1.0 hours, extract 1 time, and the extractum that during by 80 DEG C of extracting solution decompression heating simmer down tos, relative density is 1.03, as component 2;

D, component 1, component 2 are mixed with the powder that step a obtains, add with respect to the Mel of 2 times of amounts of mixture and be twisted into honey refining pill.

Embodiment 3 sucks agent

Bulbus Fritillariae Thunbergii 25g, Caulis Bambusae In Taenia 28g, Concretio Silicea Bambusae 25g, Radix Platycodonis 4g, Fructus Perillae 12g, Radix Stemonae 25g, Fructus Aristolochiae 5g, Flos Farfarae 27g, Cortex Mori 25g, Herba Ardisiae Japonicae 25g, Folium Rhododendri Daurici 26g, Fructus Momordicae 30g, Rhizoma Anemarrhenae 24g, Herba Commelinae 22g, Radix Scutellariae 20g, Radix et Rhizoma Thalictri 24g, Herba Andrographis 12g, Herba Houttuyniae 23g, Bulbus Lilii 30g, Radix Asparagi 26g, Radix Changii 25g and Rhizoma Polygonati 28g.

Its preparation process is:

The first step: by the described raw medicinal material Radix Stemonae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix et Rhizoma Thalictri, Herba Houttuyniae, Bulbus Lilii and Rhizoma Polygonati extraction by steam distillation, obtain crystal and sucking filtration liquid, sucking filtration liquid is concentrated that water extraction liquid a, crystal obtain alcohol liquid b through 82% dissolve with ethanol;

Second step: decoct with water twice after described residue raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii are mixed, add for the first time the water of 3 times of amounts, decoct 1 hour, extract decoction liquor; The water of 2 times of amounts for the second time, decocts 30 minutes, extracts decoction liquor, and decoction liquor is merged, and while then reducing pressure thin film concentration to 60 DEG C, relative density is 1.24, leaves standstill 5 hours precipitate with 82% ethanol of 3 times of amounts, and precipitate with ethanol obtains supernatant c;

The 3rd step: described supernatant c, described water extraction liquid a and described alcohol liquid b are merged, the concentrated solution that when decompression thin film concentration to 50 DEG C, relative density is 1.06, add again the metronidazole with respect to 0.002 times of amount of described concentrated solution, add water dilution, the subpackage of 1 times of amount, get final product to such an extent that suck agent.

Toxicity test

Acute oral toxicity test

One time per os gives ICR mice, body weight 18g-22g, 20, what the embodiment of the present invention 3 was obtained sucks agent as gavage agent, dosage 5000mg/kg body weight, gavage amount 20ml/kg, observe 15 days, experimental animal is not found poisoning manifestations, nothing death, locates post mortem obviously abnormal, judges that Chinese medicine composition of the present invention does not have Oral toxicity.

Long term toxicity test

Select 20 SD rats, body weight 20-30g, by the honey refining pill of the embodiment of the present invention 2 to rat by 7.4,14.8 and 16 weeks (2.0ml/100g body weight of 37.0g crude drug/kg continuous use, every day 2 times) and drug withdrawal after 4 weeks, result shows: the index such as the hair of Chinese medicine composition of the present invention to rat, behavior, defecation, body weight, organ weights, hemogram, hepatic and renal function, blood glucose, blood fat all has no significant effect, internal organs naked eyes do not find that difference changes and histological examination result shows, medication 16 weeks and drug withdrawal are after 4 weeks, and the each internal organs of rat are all without obviously changing.Illustrate that toxicity is little after Chinese medicine composition of the present invention is to rat long-term prescription, after drug withdrawal, also there is no difference reaction, application safety.

Clinical trial

Data and method

During choosing in June, 2010-2011 year June, the patient of the type of phlegm-heat stagnating in the lung obstructive emphysema that my institute receives amounts to 200 examples, in patient, male patient is 110 examples, female patient is 90 examples, wherein age distribution is 50 people in 28-48 year, 60 people in 48-55 year, 55 years old 90 above people, present obvious age growth trend, the course of disease is 6-20.All meet the diagnostic criteria of type of phlegm-heat stagnating in the lung chronic obstructive emphysema.This 200 routine patient is carried out to random packet, be divided into 100 examples for treatment by Chinese herbs group, 100 examples are tested for other drug matched group.Two groups of patients, at physical data comparing difference not statistically significants such as sex, age, the state of an illness, have comparability.

Diagnostic criteria:

1, obstructive pulmonary disease history.

2, subjective symptoms: general symptom is out of breath, cough, patient age mostly more than 40 years old, time have a more sputum crudum expectoration.

3, sign: typical emphysema patient's chest excessive expansion, shoulder is raised, and the increase of chest anteroposterior diameter is the respiratory movement of barrel chest thorax and weakens, and vocal fremitus lowers, and percussion is hyperresonant note, and border of cardiac dullness dwindles or disappears, and liver dullness circle moves down.Auscultation diminished breath sound, prolonged expiration, can hear rhonchi when forced expiration.Hear sounds is gently far away, and maximum Herzschlag point can be moved under xiphoid-process or right breast edge, and valve of pulmonary trunk second heart sound is hyperfunction, occurs distension of jugular vein, hepatomegaly, edema of lower limbs while there is pulmonary heart disease right heart failure.

4, relevant auxiliary examination: chest X ray examination, breast CT particularly high-resolution ct (HR-CT), lung function, surrounding hemogram change.

Therapeutic Method:

Treatment by Chinese herbs group: this is organized 100 routine patients and uses the spray of the embodiment of the present invention 1 to treat.Be sprayed on for 4-5 time on the one in the larynx of oral cavity, every 28 days is a course for the treatment of, and treatment is carried out 2 courses for the treatment of.

Western medicine group: this is organized 100 routine patients and uses following Western medicine partner treatment: roxithromycin dispersing tablet, oral, each 150mg/ time, 2 times/d; Compound Methoxyphenamine capsule, oral, 2 tablets/time, 3 times/d; Theo-Dur, oral, 100mg/ time, 2 times/d; Ketotifen, oral 1mg/ time, 2 times/d.Within every 28 days, be 1 course for the treatment of, treat 2 courses for the treatment of.

The standard of curative effect evaluation:

Effective: cough, uncomfortable in chest, breathe hard, dyspnea and local main physical signs disappear; Effective: cough, uncomfortable in chest, breathe hard, dyspnea alleviates or obviously alleviates; Invalid: symptom and sign are not improved.

Therapeutic outcome:

Table 1 is the drug effect comparison for the treatment of by Chinese herbs group and western medicine group:

As can be seen from Table 1, the obvious effective rate for the treatment of by Chinese herbs group and effective percentage all will, higher than western medicine group, therefore, can be learnt, Chinese medicine composition of the present invention, and in treatment type of phlegm-heat stagnating in the lung obstructive emphysema, good effect, determined curative effect, effective percentage is high.

Effective and the effective curative effect time contrast that table 2 is treatment by Chinese herbs group and western medicine group:

Group	Number of cases	The 1st course for the treatment of	The 2nd course for the treatment of
				Treatment by Chinese herbs group	99	65（65.66%)	34(34.34%)
Western medicine group	78	20(25.64%)	?58(74.36%)

As can be seen from Table 2, treatment by Chinese herbs group effective with effectively compare with western medicine group, just can there is curative effect in the short time.Can learn, Chinese medicine composition of the present invention, in treatment type of phlegm-heat stagnating in the lung obstructive emphysema, curative effect is fast, rapid-action, and treatment time is shorter.

Model case:

Liu, male, 55 years old, suffer from type of phlegm-heat stagnating in the lung obstructive emphysema existing 6 years, Symptoms is cough with dyspnea and rough breath, expectorant Huang, thickness difficulty is coughed up, fullness in the chest agitation, order is swollen, and eyeball is prominent, yellow urine dry stool, thirst with desire to drink, dimly red tongue, yellow fur, slippery and rapid pulse.Be diagnosed as type of phlegm-heat stagnating in the lung obstructive emphysema, take the honey refining pill of Chinese medicine composition embodiment 2 of the present invention, 3 times on the one, it within 28 days, is a course for the treatment of, treat 2 the course for the treatment of effect effective, cough, uncomfortable in chest, breathe hard, dyspnea and local main physical signs disappear, no side effects in treatment, follows up a case by regular visits to and does not recur half a year.

The foregoing is only preferred embodiment of the present invention, in order to limit the present invention, within the spirit and principles in the present invention not all, any amendment of doing, be equal to replacement, improvement etc., within all should being included in protection scope of the present invention.

Claims

1. treat the Chinese medicine composition of type of phlegm-heat stagnating in the lung obstructive emphysema for one kind, it is characterized in that, described Chinese medicine composition comprises following raw medicinal material: Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, the Radix Stemonae, Fructus Aristolochiae, Flos Farfarae, Cortex Mori, Herba Ardisiae Japonicae, Folium Rhododendri Daurici, Fructus Momordicae, the Rhizoma Anemarrhenae, Herba Commelinae, Radix Scutellariae, Radix et Rhizoma Thalictri, Herba Andrographis, Herba Houttuyniae, Bulbus Lilii, Radix Asparagi, Radix Changii and Rhizoma Polygonati.

2. Chinese medicine composition as claimed in claim 1, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: Bulbus Fritillariae Thunbergii 10-25 weight portion, Caulis Bambusae In Taenia 12-28 weight portion, Concretio Silicea Bambusae 10-25 weight portion, Radix Platycodonis 4-14 weight portion, Fructus Perillae 12-30 weight portion, Radix Stemonae 15-25 weight portion, Fructus Aristolochiae 5-12 weight portion, Flos Farfarae 14-27 weight portion, Cortex Mori 10-25 weight portion, Herba Ardisiae Japonicae 13-25 weight portion, Folium Rhododendri Daurici 10-26 weight portion, Fructus Momordicae 10-30 weight portion, Rhizoma Anemarrhenae 12-24 weight portion, Herba Commelinae 10-22 weight portion, Radix Scutellariae 10-20 weight portion, Radix et Rhizoma Thalictri 11-24 weight portion, Herba Andrographis 6-12 weight portion, Herba Houttuyniae 10-23 weight portion, Bulbus Lilii 15-30 weight portion, Radix Asparagi 10-26 weight portion, Radix Changii 10-25 weight portion and Rhizoma Polygonati 12-28 weight portion.

3. Chinese medicine composition as claimed in claim 1 or 2, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: Bulbus Fritillariae Thunbergii 15-25 weight portion, Caulis Bambusae In Taenia 22-28 weight portion, Concretio Silicea Bambusae 20-25 weight portion, Radix Platycodonis 4-10 weight portion, Fructus Perillae 22-30 weight portion, Radix Stemonae 15-20 weight portion, Fructus Aristolochiae 5-10 weight portion, Flos Farfarae 14-17 weight portion, Cortex Mori 10-15 weight portion, Herba Ardisiae Japonicae 13-20 weight portion, Folium Rhododendri Daurici 15-26 weight portion, Fructus Momordicae 10-20 weight portion, Rhizoma Anemarrhenae 12-20 weight portion, Herba Commelinae 15-22 weight portion, Radix Scutellariae 15-20 weight portion, Radix et Rhizoma Thalictri 11-20 weight portion, Herba Andrographis 9-12 weight portion, Herba Houttuyniae 10-15 weight portion, Bulbus Lilii 25-30 weight portion, Radix Asparagi 10-16 weight portion, Radix Changii 10-15 weight portion and Rhizoma Polygonati 22-28 weight portion.

4. the Chinese medicine composition as described in claims 1 to 3 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: Bulbus Fritillariae Thunbergii 25 weight portions, Caulis Bambusae In Taenia 28 weight portions, Concretio Silicea Bambusae 25 weight portions, Radix Platycodonis 4 weight portions, Fructus Perillae 12 weight portions, the Radix Stemonae 25 weight portions, Fructus Aristolochiae 5 weight portions, Flos Farfarae 27 weight portions, Cortex Mori 25 weight portions, Herba Ardisiae Japonicae 25 weight portions, Folium Rhododendri Daurici 26 weight portions, Fructus Momordicae 30 weight portions, the Rhizoma Anemarrhenae 24 weight portions, Herba Commelinae 22 weight portions, Radix Scutellariae 20 weight portions, Radix et Rhizoma Thalictri 24 weight portions, Herba Andrographis 12 weight portions, Herba Houttuyniae 23 weight portions, Bulbus Lilii 30 weight portions, Radix Asparagi 26 weight portions, Radix Changii 25 weight portions and Rhizoma Polygonati 28 weight portions.

5. the Chinese medicine composition as described in claim 1 to 4 any one, it is characterized in that, in described Chinese medicine composition, the ratio of weight and number of various raw medicinal materials is: Bulbus Fritillariae Thunbergii 15 weight portions, Caulis Bambusae In Taenia 22 weight portions, Concretio Silicea Bambusae 20 weight portions, Radix Platycodonis 4 weight portions, Fructus Perillae 22 weight portions, the Radix Stemonae 20 weight portions, Fructus Aristolochiae 10 weight portions, Flos Farfarae 17 weight portions, Cortex Mori 15 weight portions, Herba Ardisiae Japonicae 20 weight portions, Folium Rhododendri Daurici 26 weight portions, Fructus Momordicae 20 weight portions, the Rhizoma Anemarrhenae 20 weight portions, Herba Commelinae 15 weight portions, Radix Scutellariae 15 weight portions, Radix et Rhizoma Thalictri 11 weight portions, Herba Andrographis 9 weight portions, Herba Houttuyniae 10 weight portions, Bulbus Lilii 25 weight portions, Radix Asparagi 16 weight portions, Radix Changii 15 weight portions and Rhizoma Polygonati 28 weight portions.

6. the Chinese medicine composition as described in claim 1 to 5 any one, is characterized in that, when the dosage form of described Chinese medicine composition is spray, its preparation method is:

7. the Chinese medicine composition as described in claim 1 to 5 any one, is characterized in that, when the dosage form of described Chinese medicine composition is honey refining pill, its preparation method is:

B, get 80-94% soak with ethanol 1-3 hour, heating extraction 1-2 time that residue described raw medicinal material Bulbus Fritillariae Thunbergii, Caulis Bambusae In Taenia, Concretio Silicea Bambusae, Radix Platycodonis, Fructus Perillae, Fructus Aristolochiae, Radix Scutellariae, Herba Andrographis, Radix Asparagi and Radix Changii add 2-4 doubly to measure, each 1-3 hour, filter to obtain extracting solution, merge extractive liquid,, be the ultrafiltration post ultrafiltration of 38000-84000 again through the molecular weight that dams, ethanol is removed in ultrafiltration decompression, the extractum that simmer down to 80-90 DEG C time, relative density is 1.02-1.04, as component 1;

C, the medicinal residues that described step b is obtained add 2-4 times of water gaging and soak 1.0-2.0 hour, within 1.0-1.5 hour, extract 1 time, and the extractum that during by 80-90 DEG C of extracting solution decompression heating simmer down to, relative density is 1.03-1.08, as component 2;

8. the Chinese medicine composition as described in claim 1 to 5 any one, is characterized in that, the dosage form of described Chinese medicine composition is when sucking agent, and its preparation method is:

9. a preparation method for the Chinese medicine composition as described in claim 1 to 5 any one, is characterized in that, when the dosage form of described Chinese medicine composition is spray, its preparation method is:

C, described extractum 1 and described extractum 2 are mixed, add the deionized water doubly with respect to described mixing extractum quality 2-3, be mixed into spray.

10. the Chinese medicine composition as described in claim 1 to 5 any one, it is characterized in that, the dosage form of described Chinese medicine composition is: tablet, enteric coated tablet, sugar coated tablet, capsule, hard capsule, oral liquid, suck agent, soft capsule, spray, film coated tablet, electuary, honey refining pill, powder, granule, sublimed preparation, solution, injection, suppository, plaster, syrup and powder.