CN107126535B

CN107126535B - The application process that plant extracts is cured the disease in tcm field, health, health care are new

Info

Publication number: CN107126535B
Application number: CN201710350884.7A
Authority: CN
Inventors: 王湧钢
Original assignee: Individual
Current assignee: Individual
Priority date: 2017-05-17
Filing date: 2017-05-17
Publication date: 2018-05-01
Anticipated expiration: 2037-05-17
Also published as: CN107126535A

Abstract

Cure the disease the present invention provides a Plant Extracts in tcm field, the application process that health, health care are new, be related to plant extracts technical field, composition of plant extracts provided by the invention, including long pepper extract, capejasmine extract, garlic P.E, take dish extract and Podophyllum emodi var chinense leaf extract, cooperate and play drug effect, there is treatment and/or prevention of cardiovascular disease, good effect, strong drug action, cost is low, convenient to take, and pure plant component, there are Small side effects.The preparation method of composition of plant extracts provided by the invention, including water extraction or alcohol extracting method, have the advantages of easy to operate, of low cost.

Description

The application process that plant extracts is cured the disease in tcm field, health, health care are new

Technical field

The present invention relates to plant extracts technical field, is controlled more particularly, to a Plant Extracts in tcm field The new application process of disease, health, health care.

Background technology

Plant extracts be using plant as raw material, it is physico according to the needs of the purposes of the final products to extraction, process Learn extraction separation process, a certain kind or plurality of active ingredients in orientation acquisition and concentration plant, without changing its active ingredient Structure and the product formed.Composition according to extraction plant is different, forms glucoside, acid, polyphenol, polysaccharide, terpene, flavones, alkaloid Deng；It is different according to character, vegetable oil, medicinal extract, powder, crystalline lens etc. can be divided into.Plant extracts is a kind of plant source secondary metabolism Material, molecular weight is smaller, can be steamed with vapor, the volatility oily mater with certain smell.Plant extracts has suppression Bacterium, desinsection, anti-oxidant isoreactivity, are widely used medicine, pesticide, feed addictive, food antiseptic are fresh-keeping etc..Plant Extract has the characteristics that, from natural, comparatively safe to human body and environmental-friendly, diverse biological activities, increasingly to cause The concern of people.

Angiocardiopathy is to threaten the number one killer of human health, just has 1 because of painstaking effort in every 10 deaths in the whole world Pipe disease causes, and since its damaging range is very wide, such as without the age, point of region, has had become one that common people pay close attention to Hot spot.China's heart disease number is continuing to increase always, just has within every 10 seconds a people to die of angiocardiopathy, in every 5 adults Just there is 1 cardiac.According to the statistics of the World Health Organization, to the year two thousand twenty, China is every year because of the number of angiocardiopathy death 4,000,000 will likely be reached.Therefore how by effective intervention means, cardiovascular disease incidence rate and the death rate are reduced, As the increasingly urgent great public health problem in China or even one, the whole world.

At present, mainly there are two kinds for the treatment of means for heart class disease, one kind is operative treatment, not only costly, and And the painful and psychological burden on body can be caused to patient；Another is expectant treatment, but Western medicine side effect is larger, Decocting for Chinese herbal medicine is taken cumbersome, works slow.Both the above treatment means cannot meet good effect, strong drug action, cost at the same time Low, Small side effects are convenient to take.

Therefore, exploitation is a kind of meets good effect at the same time, and strong drug action, cost is low, Small side effects, and convenient to take is used to treat And/or prevention of cardiovascular disease medicine it is particularly important that.

In view of this, it is special to propose the present invention.

The content of the invention

First purpose of the present invention is to provide a kind of composition of plant extracts；

Second object of the present invention is to provide a kind of preparation method of above-mentioned plant extracts；

Third object of the present invention is to provide a kind of above-mentioned plant extracts in treatment and/or prevention of cardiovascular disease In application；

Fourth object of the present invention is the medicine for providing a kind for the treatment of and/or prevention of cardiovascular disease, existing to alleviate Have that drug effect present in technology is weak, of high cost, the big technical problem of side effect.

Composition of plant extracts provided by the invention, is made of the component of following parts by weight：

2-14 parts of ginseng extract, 5-30 parts of Shorthorned Epimedium P.E, 5-30 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, wolfberry fruit extract 3-15 Part, 3-15 parts of Semen Armeniacae Amarum extract, 5-30 parts of Angelica Dahurica extract, 4-24 parts of radish seed extract, dendrobium candidum extract 3-15 Part, 2-12 parts of Fructus Citri Sarcodactylis extract, 2-12 parts of Rhizoma Chuanxiong extract, 2-12 parts of licorice, 2-12 parts of dried orange peel extracts, psoralea corylifolia 3-15 parts of extract, 5-30 parts of tuckahoe extracts, 2-12 parts of Salvia root P.E, 3-15 parts of tortoiseshell extract, Caulis Kadsurae Coccineae extract 3-15 parts, 2-12 parts of Fructus Amomi extract, 4-24 parts of Astragalus Root P.E, 4-24 parts of angelica extract, 5-30 parts of Rhizoma Atractylodis Macrocephalae extract, lotus 4-24 parts of seed extract.

Further, the composition of plant extracts is also made of the component of following parts by weight：

2-14 parts of long pepper extract, 5-25 parts of capejasmine extract, 10-30 parts of garlic P.E, takes 5-25 parts of dish extract, 2-10 parts of Podophyllum emodi var chinense leaf extract.

Further, the composition of plant extracts is made of the component of following parts by weight：

2-14 parts of ginseng extract, 5-30 parts of Shorthorned Epimedium P.E, 5-30 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, wolfberry fruit extract 3-15 Part, 3-15 parts of Semen Armeniacae Amarum extract, 5-30 parts of Angelica Dahurica extract, 4-24 parts of radish seed extract, dendrobium candidum extract 3-15 Part, 2-12 parts of Fructus Citri Sarcodactylis extract, 2-12 parts of Rhizoma Chuanxiong extract, 2-12 parts of licorice, 2-12 parts of dried orange peel extracts, psoralea corylifolia 3-15 parts of extract, 5-30 parts of tuckahoe extracts, 2-12 parts of Salvia root P.E, 3-15 parts of tortoiseshell extract, Caulis Kadsurae Coccineae extract 3-15 parts, 2-12 parts of Fructus Amomi extract, 4-24 parts of Astragalus Root P.E, 4-24 parts of angelica extract, 5-30 parts of Rhizoma Atractylodis Macrocephalae extract, lotus 4-24 parts of seed extract, 2-14 parts of long pepper extract, 5-25 parts of capejasmine extract, 10-30 parts of garlic P.E, takes dish extract 5-25 parts, 2-10 parts of Podophyllum emodi var chinense leaf extract.

6-10 parts of ginseng extract, 10-20 parts of Shorthorned Epimedium P.E, 10-20 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, wolfberry fruit extract 7- 11 parts, 7-11 parts of Semen Armeniacae Amarum extract, 10-20 parts of Angelica Dahurica extract, 12-16 parts of radish seed extract, dendrobium candidum extract 7-11 parts, 6-8 parts of Fructus Citri Sarcodactylis extract, 6-8 parts of Rhizoma Chuanxiong extract, 6-8 parts of licorice, 6-8 parts of dried orange peel extracts, psoralea corylifolia 7-11 parts of extract, 10-20 parts of tuckahoe extracts, 6-8 parts of Salvia root P.E, 7-11 parts of tortoiseshell extract, Caulis Kadsurae Coccineae extract 7-11 parts, 6-8 parts of Fructus Amomi extract, 12-16 parts of Astragalus Root P.E, 12-16 parts of angelica extract, 10-20 parts of Rhizoma Atractylodis Macrocephalae extract, 12-16 parts of Semen Nelumbinis extract, 6-10 parts of long pepper extract, 10-20 parts of capejasmine extract, 15-25 parts of garlic P.E, Fei Caiti Take 10-20 parts of thing, 4-8 parts of Podophyllum emodi var chinense leaf extract.

8 parts of ginseng extract, 15 parts of Shorthorned Epimedium P.E, 15 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, 9 parts of wolfberry fruit extract, semen armeniacae amarae 9 parts of extract, 15 parts of Angelica Dahurica extract, 14 parts of radish seed extract, 9 parts of dendrobium candidum extract, 7 parts of Fructus Citri Sarcodactylis extract, river 7 parts of rhizome of chuanxiong extract, 7 parts of licorice, 7 parts of dried orange peel extracts, 9 parts of Fructus Psoraleae extract, 15 parts of tuckahoe extracts, Radix Salviae Miltiorrhizae carries Take 7 parts of thing, 9 parts of tortoiseshell extract, 9 parts of Caulis Kadsurae Coccineae extract, 7 parts of Fructus Amomi extract, 14 parts of Astragalus Root P.E, angelica extract 14 parts, 15 parts of Rhizoma Atractylodis Macrocephalae extract, 14 parts of Semen Nelumbinis extract, 8 parts of long pepper extract, 15 parts of capejasmine extract, garlic P.E 20 Part, take 15 parts of dish extract, 6 parts of Podophyllum emodi var chinense leaf extract.

Present invention also offers the preparation method of above-mentioned composition of plant extracts, the preparation method is chemical solvent Extraction method.

Further, when chemical solvent is water, the chemical solvent extraction method includes the following steps：

Step (a)：Take 2-14 parts of ginseng, 5-30 parts of Herba Epimedii, 5-30 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 3-15 parts of matrimony vine, semen armeniacae amarae 3-15 Part, 5-30 parts of the root of Dahurain angelica, 4-24 parts of radish seed, 3-15 parts of dendrobium candidum, 2-12 parts of fingered citron, 2-12 parts of Ligusticum wallichii, 2-12 parts of radix glycyrrhizae are old 2-12 parts of skin, 3-15 parts of psoralea corylifolia, 5-30 parts of Poria cocos, 2-12 parts of Radix Salviae Miltiorrhizae, 3-15 parts of tortoiseshell, black tiger 3-15 parts, fructus amomi 2-12 Part, 4-24 parts of radix astragali, 4-24 parts of Angelica sinensis, 5-30 parts of Rhizoma Atractylodis Macrocephalae, 4-24 parts of lotus seeds, 2-14 parts of the Bi roots of grass, 5-25 parts of cape jasmine, garlic 10- 30 parts, take 5-25 parts of dish, 2-10 parts of common dysosma leaf, obtains corresponding powder after being crushed respectively；

Step (b)：The powder is mixed with the water of 5-15 times of weight respectively, is extracted, obtains mixed liquor；The leaching Temperature raising degree is 60-100 DEG C, and when the extraction time is 1-10 small, the extracting times are 3-7 times；

Step (c)：The mixed liquor is filtered, obtains filtrate；

Step (d)：The filtrate is distilled, is evaporated completely to moisture, obtains the corresponding plant extracts.

Further, when chemical solvent is nonaqueous solvents, the chemical solvent extraction method includes the following steps：

Step (B)：The powder is mixed with the alcohol of 8-20 times of weight respectively, is extracted, obtains mixed liquor；The leaching Temperature raising degree is 55-85 DEG C, and when the extraction time is 1-6 small, the extracting times are 2-5 times；

Step (C)：The mixed liquor is filtered, obtains filtrate；

Step (D)：No alcohol is concentrated into the filtrate, obtains the corresponding plant extracts.

Present invention also offers above-mentioned composition of plant extracts to prepare the medicine for the treatment of and/or prevention of cardiovascular disease Application in thing.

To be carried in addition, present invention also offers a kind for the treatment of and/or the medicine of prevention of cardiovascular disease, including above-mentioned plant Take thing and pharmaceutically acceptable carrier.

Composition of plant extracts provided by the invention, including ginseng extract, Shorthorned Epimedium P.E, RADIX POLYGONI MULTIFLORI PREPARATA extraction Thing, wolfberry fruit extract, Semen Armeniacae Amarum extract, Angelica Dahurica extract, radish seed extract, dendrobium candidum extract, Fructus Citri Sarcodactylis extract, Rhizoma Chuanxiong extract, licorice, dried orange peel extracts, Fructus Psoraleae extract, tuckahoe extracts, Salvia root P.E, tortoiseshell extraction Thing, Caulis Kadsurae Coccineae extract, Fructus Amomi extract, Astragalus Root P.E, angelica extract, Rhizoma Atractylodis Macrocephalae extract and Semen Nelumbinis extract, mutually Coordinating and play drug effect, there is treatment and/or prevention of cardiovascular disease, good effect, strong drug action, cost is low, convenient to take, And pure plant component, there are Small side effects.The preparation method of composition of plant extracts provided by the invention, including water Extraction or alcohol extracting method, have the advantages of easy to operate, of low cost.

Embodiment

In order to illustrate more clearly of the present invention, with reference to preferred embodiment, the present invention is described further.Ability Field technique personnel should be appreciated that following specifically described content is illustrative and be not restrictive, this should not be limited with this The protection domain of invention.The person that is not specified actual conditions in embodiment, the condition suggested according to normal condition or manufacturer carry out.Institute Production firm person is not specified with instrument or instrument, is the conventional products that can be obtained by commercially available purchase.

At present, mainly there are two kinds for the treatment of means for heart class disease, one kind is operative treatment, not only costly, and And the painful and psychological burden on body can be caused to patient；Another is expectant treatment, but Western medicine side effect is larger, Decocting for Chinese herbal medicine is taken cumbersome, works slow.

Therefore, in view of the above-mentioned problems, the present invention provides a kind of composition of plant extracts, the group of following parts by weight is included Point：

Wherein, plant extracts for example can be, but be not limited to plant sapogenin glycoside, glycosides, one kind in glucoside or plant polyose or It is a variety of.

In the present invention, composition of plant extracts further includes the component of following parts by weight：

Above component, which cooperates, plays drug effect, has effects that treatment and/or prevention of cardiovascular disease, good effect, medicine Effect is strong, and cost is low, convenient to take, and pure plant component, has the advantages that Small side effects.

Wherein, the Bi roots of grass is pungent, heat；There is special fragrance, acrid flavour is peppery；Return stomach, large intestine channel；With middle benefit gas, cold dispelling, lower gas, stops The effect of pain, control trusted subordinate's crymodynia, vomits acid regurgitation, increased borborygmus and diarrhea, cold dysentery, cloudy hernia, headache, nasosinusitis, dentalgia.

Cape jasmine is cold in nature；Gas is micro-, and taste is slightly sour and bitter；Enter lung, stomach, liver, courage, three burnt, collaterals of the uterus the six channels；With purging intense heat relieving restlessness, clearly The effect of hot diuresis, removing pattogenic heat from the blood and toxic material from the body, for Vexed, jaundice, blood strangury and dry pain, blood-head tells nosebleed, red eye, swell pain, fiery poison sore Ulcer；Control bruise pain outside.

Garlic property is sweet, heat；Enter spleen, stomach, lung channel；The effect of with row stagnant gas, warming spleen and stomach, eliminating mass product, detoxifies, desinsection, controls Eating accumulation, coldness and pain in the epigastrium, oedema turgor, diarrhea, dysentery, malaria, pertussis, swollen ulcer drug, white bald tinea sore, snakebite and bugbite.

Take dish, property acid, puts down；Enter the heart, liver, spleen three to pass through；The effect of with promoting blood circulation, hemostasis, calming heart, dampness removing, subsides a swelling, removing toxic substances, Traumatic injury is controlled, hemoptysis, spits blood, have blood in stool, palpitaition, carbuncle swells.

Common dysosma leaf is pungent, warm；Enter the heart channel of Hang-Shaoyin；Asthma is controlled, carbuncle on the back is festered.

In the present invention, the composition of plant extracts is made of the component of following parts by weight：

Wherein, ginseng extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 8 parts, 10 parts, 12 parts or 14 parts；It is excessive Sheep leaves of pulse plants extract for example can be, but be not limited to 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or 30 parts；RADIX POLYGONI MULTIFLORI PREPARATA extract for example may be used Think, but be not limited to 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or 30 parts；Wolfberry fruit extract for example can be, but be not limited to 3 parts, 7 Part, 9 parts, 11 parts or 15 parts；Semen Armeniacae Amarum extract for example can be, but be not limited to 3 parts, 7 parts, 9 parts, 11 parts or 15 parts；The root of Dahurain angelica Extract for example can be, but be not limited to 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or 30 parts；Radish seed extract for example can be with For, but 4 parts are not limited to, 8 parts, 12 parts, 14 parts, 16 parts, 20 parts or 24 parts；Dendrobium candidum extract for example can be, but unlimited In 3 parts, 7 parts, 9 parts, 11 parts or 15 parts；Fructus Citri Sarcodactylis extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 7 parts, 8 parts, 10 Part or 12 parts；Rhizoma Chuanxiong extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 7 parts, 8 parts, 10 parts or 12 parts；Radix glycyrrhizae is extracted Thing for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 7 parts, 8 parts, 10 parts or 12 parts；Dried orange peel extracts for example can be, but not It is limited to 2 parts, 4 parts, 6 parts, 7 parts, 8 parts, 10 parts or 12 parts；Fructus Psoraleae extract for example can be, but be not limited to 3 parts, 7 parts, 9 Part, 11 parts or 15 parts；Tuckahoe extracts for example can be, but be not limited to 5 parts, 10 parts, 15 parts, 20 parts, 25 parts or 30 parts；Radix Salviae Miltiorrhizae Extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 7 parts, 8 parts, 10 parts or 12 parts；Tortoiseshell extract for example can be, But 3 parts are not limited to, 7 parts, 9 parts, 11 parts or 15 parts；Caulis Kadsurae Coccineae extract for example can be, but be not limited to 3 parts, 7 parts, 9 parts, 11 Part or 15 parts；Fructus Amomi extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 7 parts, 8 parts, 10 parts or 12 parts；Astragalus extraction Thing for example can be, but be not limited to 4 parts, 8 parts, 12 parts, 14 parts, 16 parts, 20 parts or 24 parts；Angelica extract for example can be, But 4 parts are not limited to, 8 parts, 12 parts, 14 parts, 16 parts, 20 parts or 24 parts；Rhizoma Atractylodis Macrocephalae extract for example can be, but be not limited to 5 parts, 10 Part, 15 parts, 20 parts, 25 parts or 30 parts；Semen Nelumbinis extract for example can be, but be not limited to 4 parts, 8 parts, 12 parts, 14 parts, 16 parts, 20 parts or 24 parts；Long pepper extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 8 parts, 10 parts, 12 parts or 14 parts；Cape jasmine Extract for example can be, but be not limited to 5 parts, 10 parts, 15 parts, 20 parts or 25 parts；Garlic P.E for example can be, but unlimited In 10 parts, 15 parts, 20 parts, 25 parts or 30 parts；Expense dish extract for example can be but to be not limited to 5 parts, 10 parts, 15 parts, 20 parts or 25 parts；Podophyllum emodi var chinense leaf extract for example can be, but be not limited to 2 parts, 4 parts, 6 parts, 8 parts or 10 parts.

In one preferred embodiment, composition of plant extracts is made of the component of following parts by weight：

Present invention also offers the preparation method of above-mentioned composition of plant extracts, including aqueous solvent extraction method or chemical solution Agent extraction method.

Wherein, aqueous solvent includes pure water, distilled water or deionized water；Chemical solvent includes alcohol, ester, hydrocarbon, ketone, ether.Alcohol Such as can be, but methanol is not limited to, ethanol or propyl alcohol；Ester for example can be, but be not limited to ethyl acetate, pentyl acetate or second Acid butyl ester；Hydrocarbon for example can be, but be not limited to alkene or isoparaffin；Ketone for example can be, but be not limited to acetone, dimethyl ketone Or dimethylketazine；Ether for example can be, but be not limited to petroleum ether or ether.

In the present invention, aqueous solvent extraction method includes the following steps：

Step (c)：The mixed liquor is filtered, obtains filtrate；

Wherein, in one preferred embodiment, in step (a), 8 parts of ginseng, 15 parts of Herba Epimedii, RADIX POLYGONI MULTIFLORI PREPARATA 15 are taken Part, 9 parts of matrimony vine, 9 parts of semen armeniacae amarae, 15 parts of the root of Dahurain angelica, 14 parts of radish seed, 9 parts of dendrobium candidum, 7 parts of fingered citron, 7 parts of Ligusticum wallichii, 7 parts of radix glycyrrhizae, 7 parts of dried orange peel, 9 parts of psoralea corylifolia, 15 parts of Poria cocos, 7 parts of Radix Salviae Miltiorrhizae, 9 parts of tortoiseshell, black 9 parts of tiger, 7 parts of fructus amomi, 14 parts of radix astragali, Angelica sinensis 14 Part, 15 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of lotus seeds, 8 parts of the Bi roots of grass, 15 parts of cape jasmine, 20 parts of garlic, takes 15 parts of dish, 6 parts of common dysosma leaf.

In step (b), adding the weight of water for example can be, but be not limited to 5 times of powder, 10 times or 15 times；Extraction temperature Degree for example can be, but be not limited to 60 DEG C, 70 DEG C, 80 DEG C, 90 DEG C or 100 DEG C；Extraction time for example can be, but be not limited to 1 Hour, 2 it is small when, 3 it is small when, 4 it is small when, 5 it is small when, 6 it is small when, 7 it is small when, 8 it is small when, 9 it is small when or 10 it is small when；Extracting times for example can be with For, but be not limited to 3 times, 4 times, 5 times, 6 times or 7 times.

Using aqueous solvent extraction method prepared by composition of plant extracts provided by the invention, it is easy to operate, save The energy, rapidly and efficiently, and water is nontoxic, will not produce harmful material.

In the present invention, chemical solvent extraction method includes the following steps：

Step (A)：Taking 2-14 parts of the Bi roots of grass, 5-25 parts of cape jasmine, 10-30 parts of garlic takes 5-25 parts of dish, 2-10 parts of common dysosma leaf, Corresponding powder is obtained after being crushed respectively；

Step (C)：The mixed liquor is filtered, obtains filtrate；

In step (B), adding the weight of water for example can be, but be not limited to 8 times of powder, 10 times, 12 times, 14 times, 16 Times, 18 times or 20 times；Extraction temperature for example can be, but be not limited to 55 DEG C, 60 DEG C, 65 DEG C, 70 DEG C, 75 DEG C, 80 DEG C or 85 DEG C； Extraction time for example can be, but be not limited to 1 it is small when, 2 it is small when, 3 it is small when, 4 it is small when, 5 it is small when or 6 it is small when；Extracting times are for example It can be, but be not limited to 2 times, 3 times, 4 times or 5 times.

Using organic solvent extraction prepared by composition of plant extracts provided by the invention, easy to operate, section The about energy, rapidly and efficiently, mild condition, does not destroy original effective component, can effectively extract the extract in each component, impurity It is few.

Present invention also offers application of the above-mentioned composition of plant extracts in treatment and/or prevention of cardiovascular disease.

Wherein, angiocardiopathy includes one kind of coronary heart disease, myocarditis, heart valve disease, hypertension, hyperlipidemia and heart failure It is or a variety of.

In addition, present invention also offers a kind for the treatment of and/or the medicine of prevention of cardiovascular disease, including above-mentioned plant extract Thing and pharmaceutically acceptable carrier.

Wherein, pharmaceutically acceptable carrier includes lactose, chitosan, gel, agar, cholesterol, liposome, ring paste Essence, vegetable oil, microballoon or micro-capsule.

In order to contribute to the clearer understanding present invention, below in conjunction with embodiment and comparative example to technical side of the invention Case is described further.

Embodiment 1

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 8 parts of ginseng, 15 parts of Herba Epimedii, system 15 parts of the tuber of multiflower knotweed, 9 parts of matrimony vine, 9 parts of semen armeniacae amarae, 15 parts of the root of Dahurain angelica, 14 parts of radish seed, 9 parts of dendrobium candidum, 7 parts of fingered citron, 7 parts of Ligusticum wallichii are sweet 7 parts of grass, 7 parts of dried orange peel, 9 parts of psoralea corylifolia, 15 parts of Poria cocos, 7 parts of Radix Salviae Miltiorrhizae, 9 parts of tortoiseshell, black 9 parts of tiger, 7 parts of fructus amomi, 14 parts of radix astragali, 14 parts of Angelica sinensis, 15 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of lotus seeds.

Embodiment 2

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 8 parts of ginseng, 15 parts of Herba Epimedii, system 15 parts of the tuber of multiflower knotweed, 9 parts of matrimony vine, 9 parts of semen armeniacae amarae, 15 parts of the root of Dahurain angelica, 14 parts of radish seed, 9 parts of dendrobium candidum, 7 parts of fingered citron, 7 parts of Ligusticum wallichii are sweet 7 parts of grass, 7 parts of dried orange peel, 9 parts of psoralea corylifolia, 15 parts of Poria cocos, 7 parts of Radix Salviae Miltiorrhizae, 9 parts of tortoiseshell, black 9 parts of tiger, 7 parts of fructus amomi, 14 parts of radix astragali, 14 parts of Angelica sinensis, 15 parts of Rhizoma Atractylodis Macrocephalae, 14 parts of lotus seeds, 8 parts of the Bi roots of grass, 15 parts of cape jasmine, 20 parts of garlic, takes 15 parts of dish, 6 parts of common dysosma leaf.

Embodiment 3

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 2 parts of ginseng, 5 parts of Herba Epimedii, system is first 5 parts of crow, 3 parts of matrimony vine, 3 parts of semen armeniacae amarae, 5 parts of the root of Dahurain angelica, 4 parts of radish seed, 3 parts of dendrobium candidum, 2 parts of fingered citron, 2 parts of Ligusticum wallichii, radix glycyrrhizae 2 Part, 2 parts of dried orange peel, 3 parts of psoralea corylifolia, 5 parts of Poria cocos, 2 parts of Radix Salviae Miltiorrhizae, 3 parts of tortoiseshell, black 3 parts of tiger, 2 parts of fructus amomi, 4 parts of radix astragali, Angelica sinensis 4 Part, 5 parts of Rhizoma Atractylodis Macrocephalae, 4 parts of lotus seeds, 2 parts of the Bi roots of grass, 5 parts of cape jasmine, 10 parts of garlic, takes 5 parts of dish, 2 parts of common dysosma leaf.

Embodiment 4

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 6 parts of ginseng, 10 parts of Herba Epimedii, system 10 parts of the tuber of multiflower knotweed, 7 parts of matrimony vine, 7 parts of semen armeniacae amarae, 10 parts of the root of Dahurain angelica, 12 parts of radish seed, 7 parts of dendrobium candidum, 6 parts of fingered citron, 6 parts of Ligusticum wallichii are sweet 6 parts of grass, 6 parts of dried orange peel, 7 parts of psoralea corylifolia, 10 parts of Poria cocos, 6 parts of Radix Salviae Miltiorrhizae, 7 parts of tortoiseshell, black 7 parts of tiger, 6 parts of fructus amomi, 12 parts of radix astragali, 12 parts of Angelica sinensis, 10 parts of Rhizoma Atractylodis Macrocephalae, 12 parts of lotus seeds, 6 parts of the Bi roots of grass, 10 parts of cape jasmine, 15 parts of garlic, takes 10 parts of dish, 4 parts of common dysosma leaf.

Embodiment 5

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 10 parts of ginseng, 20 parts of Herba Epimedii, system 20 parts of the tuber of multiflower knotweed, 11 parts of matrimony vine, 11 parts of semen armeniacae amarae, 20 parts of the root of Dahurain angelica, 16 parts of radish seed, 11 parts of dendrobium candidum, 8 parts of fingered citron, Ligusticum wallichii 8 Part, 8 parts of radix glycyrrhizae, 8 parts of dried orange peel, 11 parts of psoralea corylifolia, 20 parts of Poria cocos, 8 parts of Radix Salviae Miltiorrhizae, 11 parts of tortoiseshell, black 11 parts of tiger, 8 parts of fructus amomi, Huang 16 parts of stilbene, 16 parts of Angelica sinensis, 20 parts of Rhizoma Atractylodis Macrocephalae, 16 parts of lotus seeds, 10 parts of the Bi roots of grass, 20 parts of cape jasmine, 25 parts of garlic, takes 20 parts of dish, common dysosma leaf 8 Part.

Embodiment 6

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 14 parts of ginseng, 30 parts of Herba Epimedii, system 30 parts of the tuber of multiflower knotweed, 15 parts of matrimony vine, 15 parts of semen armeniacae amarae, 30 parts of the root of Dahurain angelica, 24 parts of radish seed, 15 parts of dendrobium candidum, 12 parts of fingered citron, Ligusticum wallichii 12 Part, 12 parts of radix glycyrrhizae, 12 parts of dried orange peel, 15 parts of psoralea corylifolia, 30 parts of Poria cocos, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of tortoiseshell, black 15 parts of tiger, fructus amomi 12 Part, 24 parts of radix astragali, 24 parts of Angelica sinensis, 30 parts of Rhizoma Atractylodis Macrocephalae, 24 parts of lotus seeds, 14 parts of the Bi roots of grass, 25 parts of cape jasmine, 30 parts of garlic, takes 25 parts of dish, ghost 10 parts of prostheca.

Comparative example 1

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 1 part of ginseng, 3 parts of Herba Epimedii, system is first 3 parts of crow, 2 parts of matrimony vine, 2 parts of semen armeniacae amarae, 3 parts of the root of Dahurain angelica, 2 parts of radish seed, 2 parts of dendrobium candidum, 1 part of fingered citron, 1 part of Ligusticum wallichii, radix glycyrrhizae 1 Part, 1 part of dried orange peel, 2 parts of psoralea corylifolia, 3 parts of Poria cocos, 1 part of Radix Salviae Miltiorrhizae, 2 parts of tortoiseshell, black 2 parts of tiger, 1 part of fructus amomi, 2 parts of radix astragali, Angelica sinensis 2 Part, 3 parts of Rhizoma Atractylodis Macrocephalae, 2 parts of lotus seeds, 14 parts of the Bi roots of grass, 25 parts of cape jasmine, 30 parts of garlic, takes 25 parts of dish, 10 parts of common dysosma leaf.

Comparative example 2

According to following prescription, respectively according to the appropriate raw material in weight fraction city, wherein, 14 parts of ginseng, 30 parts of Herba Epimedii, system 30 parts of the tuber of multiflower knotweed, 15 parts of matrimony vine, 15 parts of semen armeniacae amarae, 30 parts of the root of Dahurain angelica, 24 parts of radish seed, 15 parts of dendrobium candidum, 12 parts of fingered citron, Ligusticum wallichii 12 Part, 12 parts of radix glycyrrhizae, 12 parts of dried orange peel, 15 parts of psoralea corylifolia, 30 parts of Poria cocos, 12 parts of Radix Salviae Miltiorrhizae, 15 parts of tortoiseshell, black 15 parts of tiger, fructus amomi 12 Part, 24 parts of radix astragali, 24 parts of Angelica sinensis, 30 parts of Rhizoma Atractylodis Macrocephalae, 24 parts of lotus seeds, 2 parts of the Bi roots of grass, 5 parts of cape jasmine, 10 parts of garlic, takes 5 parts of dish, Podophyllum emodi var chinense 2 parts of leaf.

Method prepared plant extracts composition is prepared as follows：

Step (a)：Each raw material components of above-described embodiment 1 to 6 and comparative example 1 and comparative example 2 are taken, after being crushed respectively Obtain corresponding powder；

Step (b)：The powder is mixed with the pure water of 10 times of weight respectively, is extracted, obtains mixed liquor；It is described Extraction temperature is 80 DEG C, and when the extraction time is 5 small, the extracting times are 5 times；

Step (c)：The mixed liquor is filtered, obtains filtrate；

Or：

Step (B)：The powder is mixed with the ethanol of 14 times of weight respectively, is extracted, obtains mixed liquor；The leaching Temperature raising degree is 70 DEG C, and when the extraction time is 3 small, the extracting times are 3 times；

Step (C)：The mixed liquor is filtered, obtains filtrate；

Step (D)：No ethanol is concentrated into the filtrate, obtains the corresponding plant extracts.

After each component for the above-mentioned each example composition of plant extracts being prepared is mixed by corresponding proportioning, use respectively Olive oil is collectively disposed in soft capsule as carrier, stand-by.

The clinical trial of composition of plant extracts treatment angiocardiopathy provided by the invention

The effect of in order to help preferably to embody composition of plant extracts provided by the invention, in conjunction with specifically facing Bed data are described below.

Clinical data：Clinical case totally 150, wherein male 82, women 68；Age is 34 years old minimum, 78 years old maximum； The course of disease is most 3 months short, most 10 years long；All cases all suffer from coronary heart disease, myocarditis, heart valve disease, hypertension, hyperlipidemia or The one or more of heart failure.

Treatment method：The composition of plant extracts capsule that the component of 1-6 of embodiment of the present invention offers is prepared is taken, 2 tablets each time, 2 times a day, it is 1 course for the treatment of to take orally 3 months to each patient.

Curative effect determinate standard：

Clinical cure：Subjective symptoms sign disappears, and continuous 3 times of training inspection result can be consolidated in range of normal value；

It is effective：Subjective symptoms sign largely disappears, and training inspection result is clearly better, normal or close normal；

Effectively：Subjective symptoms sign is obviously improved, and training inspection result has improved；

It is invalid：Pretherapy and post-treatment symptom and sign and training check numerical value substantially without improvement.

Therapeutic effect is specifically as shown in table 1.

1 therapeutic effect of table

Group	Cure rate (%)	Obvious effective rate (%)	Efficient (%)	Inefficiency (%)
					Embodiment 1	82	10	5	3
Embodiment 2	93	5	2	0
					Embodiment 3	84	7	7	2
Embodiment 4	90	5	5	0
					Embodiment 5	87	6	5	2
Embodiment 6	85	13	1	1
					Comparative example 1	62	5	14	19
Comparative example 2	58	11	16	15

The plant being prepared it can be seen from above clinical effectiveness using 1-6 of the embodiment of the present invention components provided carries Compositions are taken to have preferable therapeutic effect to angiocardiopathy, cure rate is up to more than 80%, and inefficiency is less than 3%；When The composition of plant extracts that the component provided using the embodiment of the present invention 2 is prepared, i.e. 8 parts of ginseng extract, Herba Epimedii 15 parts of extract, 15 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, 9 parts of wolfberry fruit extract, 9 parts of Semen Armeniacae Amarum extract, 15 parts of Angelica Dahurica extract, radish 14 parts of seed extract, 9 parts of dendrobium candidum extract, 7 parts of Fructus Citri Sarcodactylis extract, 7 parts of Rhizoma Chuanxiong extract, 7 parts of licorice, dried orange peel 7 parts of extract, 9 parts of Fructus Psoraleae extract, 15 parts of tuckahoe extracts, 7 parts of Salvia root P.E, 9 parts of tortoiseshell extract, black tiger carries Take 9 parts of thing, 7 parts of Fructus Amomi extract, 14 parts of Astragalus Root P.E, 14 parts of angelica extract, 15 parts of Rhizoma Atractylodis Macrocephalae extract, Semen Nelumbinis extract 14 parts, 8 parts of long pepper extract, 15 parts of capejasmine extract, 20 parts of garlic P.E, takes 15 parts of dish extract, Podophyllum emodi var chinense leaf extract 6 During part, best to the therapeutic effect of angiocardiopathy, cure rate is up to 93%, inefficiency 0.

In conclusion composition of plant extracts provided by the invention, cooperate and play drug effect, have treatment and/or The effect of prevention of cardiovascular disease, good effect, strong drug action, cost is low, convenient to take, and pure plant component, has Small side effects The advantages of.

Finally it should be noted that：The above embodiments are only used to illustrate the technical solution of the present invention., rather than its limitations；To the greatest extent Pipe is described in detail the present invention with reference to foregoing embodiments, it will be understood by those of ordinary skill in the art that：Its according to Can so modify to the technical solution described in foregoing embodiments, either to which part or all technical characteristic into Row equivalent substitution；And these modifications or replacement, the essence of appropriate technical solution is departed from various embodiments of the present invention technology The scope of scheme.

Claims

1. a kind for the treatment of and/or the composition of plant extracts of prevention of cardiovascular disease, it is characterised in that the plant extracts It is made of the component of following parts by weight：

2-14 parts of ginseng extract, 5-30 parts of Shorthorned Epimedium P.E, 5-30 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, 3-15 parts of wolfberry fruit extract, 3-15 parts of Semen Armeniacae Amarum extract, 5-30 parts of Angelica Dahurica extract, 4-24 parts of radish seed extract, 3-15 parts of dendrobium candidum extract, 2-12 parts of Fructus Citri Sarcodactylis extract, 2-12 parts of Rhizoma Chuanxiong extract, 2-12 parts of licorice, 2-12 parts of dried orange peel extracts, psoralea corylifolia carries Take 3-15 parts of thing, 5-30 parts of tuckahoe extracts, 2-12 parts of Salvia root P.E, 3-15 parts of tortoiseshell extract, Caulis Kadsurae Coccineae extract 3- 15 parts, 2-12 parts of Fructus Amomi extract, 4-24 parts of Astragalus Root P.E, 4-24 parts of angelica extract, 5-30 parts of Rhizoma Atractylodis Macrocephalae extract, lotus seeds 4-24 parts of extract.

2. composition of plant extracts according to claim 1, it is characterised in that the composition of plant extracts also by The component composition of following parts by weight：

2-14 parts of long pepper extract, 5-25 parts of capejasmine extract, 10-30 parts of garlic P.E, takes 5-25 parts of dish extract, Podophyllum emodi var chinense 2-10 parts of leaf extract.

3. composition of plant extracts according to claim 2, it is characterised in that the composition of plant extracts by with The component composition of lower parts by weight：

2-14 parts of ginseng extract, 5-30 parts of Shorthorned Epimedium P.E, 5-30 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, 3-15 parts of wolfberry fruit extract, 3-15 parts of Semen Armeniacae Amarum extract, 5-30 parts of Angelica Dahurica extract, 4-24 parts of radish seed extract, 3-15 parts of dendrobium candidum extract, 2-12 parts of Fructus Citri Sarcodactylis extract, 2-12 parts of Rhizoma Chuanxiong extract, 2-12 parts of licorice, 2-12 parts of dried orange peel extracts, psoralea corylifolia carries Take 3-15 parts of thing, 5-30 parts of tuckahoe extracts, 2-12 parts of Salvia root P.E, 3-15 parts of tortoiseshell extract, Caulis Kadsurae Coccineae extract 3- 15 parts, 2-12 parts of Fructus Amomi extract, 4-24 parts of Astragalus Root P.E, 4-24 parts of angelica extract, 5-30 parts of Rhizoma Atractylodis Macrocephalae extract, lotus seeds 4-24 parts of extract, 2-14 parts of long pepper extract, 5-25 parts of capejasmine extract, 10-30 parts of garlic P.E, takes dish extract 5- 25 parts, 2-10 parts of Podophyllum emodi var chinense leaf extract.

4. composition of plant extracts according to claim 3, it is characterised in that the composition of plant extracts by with The component composition of lower parts by weight：

6-10 parts of ginseng extract, 10-20 parts of Shorthorned Epimedium P.E, 10-20 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, wolfberry fruit extract 7-11 Part, 7-11 parts of Semen Armeniacae Amarum extract, 10-20 parts of Angelica Dahurica extract, 12-16 parts of radish seed extract, dendrobium candidum extract 7- 11 parts, 6-8 parts of Fructus Citri Sarcodactylis extract, 6-8 parts of Rhizoma Chuanxiong extract, 6-8 parts of licorice, 6-8 parts of dried orange peel extracts, psoralea corylifolia carries Take 7-11 parts of thing, 10-20 parts of tuckahoe extracts, 6-8 parts of Salvia root P.E, 7-11 parts of tortoiseshell extract, Caulis Kadsurae Coccineae extract 7- 11 parts, 6-8 parts of Fructus Amomi extract, 12-16 parts of Astragalus Root P.E, 12-16 parts of angelica extract, 10-20 parts of Rhizoma Atractylodis Macrocephalae extract, lotus 12-16 parts of seed extract, 6-10 parts of long pepper extract, 10-20 parts of capejasmine extract, 15-25 parts of garlic P.E, takes dish extraction 10-20 parts of thing, 4-8 parts of Podophyllum emodi var chinense leaf extract.

5. composition of plant extracts according to claim 4, it is characterised in that the composition of plant extracts by with The component composition of lower parts by weight：

8 parts of ginseng extract, 15 parts of Shorthorned Epimedium P.E, 15 parts of RADIX POLYGONI MULTIFLORI PREPARATA extract, 9 parts of wolfberry fruit extract, semen armeniacae amarae extraction 9 parts of thing, 15 parts of Angelica Dahurica extract, 14 parts of radish seed extract, 9 parts of dendrobium candidum extract, 7 parts of Fructus Citri Sarcodactylis extract, Ligusticum wallichii carries Take 7 parts of thing, 7 parts of licorice, 7 parts of dried orange peel extracts, 9 parts of Fructus Psoraleae extract, 15 parts of tuckahoe extracts, Salvia root P.E 7 parts, 9 parts of tortoiseshell extract, 9 parts of Caulis Kadsurae Coccineae extract, 7 parts of Fructus Amomi extract, 14 parts of Astragalus Root P.E, angelica extract 14 Part, 15 parts of Rhizoma Atractylodis Macrocephalae extract, 14 parts of Semen Nelumbinis extract, 8 parts of long pepper extract, 15 parts of capejasmine extract, 20 parts of garlic P.E, Take 15 parts of dish extract, 6 parts of Podophyllum emodi var chinense leaf extract.

6. such as the preparation method of claim 3-5 any one of them composition of plant extracts, it is characterised in that the preparation Method is chemical solvent extraction method.

7. preparation method according to claim 6, it is characterised in that when chemical solvent is water, the chemical solvent carries Follow the example of and include the following steps：

Step (a)：Take 2-14 parts of ginseng, 5-30 parts of Herba Epimedii, 5-30 parts of RADIX POLYGONI MULTIFLORI PREPARATA, 3-15 parts of matrimony vine, 3-15 parts of semen armeniacae amarae, in vain 5-30 parts of the root of Dahurian angelica, 4-24 parts of radish seed, 3-15 parts of dendrobium candidum, 2-12 parts of fingered citron, 2-12 parts of Ligusticum wallichii, 2-12 parts of radix glycyrrhizae, dried orange peel 2- 12 parts, 3-15 parts of psoralea corylifolia, 5-30 parts of Poria cocos, 2-12 parts of Radix Salviae Miltiorrhizae, 3-15 parts of tortoiseshell, black tiger 3-15 parts, 2-12 parts of fructus amomi is yellow 4-24 parts of stilbene, 4-24 parts of Angelica sinensis, 5-30 parts of Rhizoma Atractylodis Macrocephalae, 4-24 parts of lotus seeds, 2-14 parts of the Bi roots of grass, 5-25 parts of cape jasmine, 10-30 parts of garlic, Take 5-25 parts of dish, 2-10 parts of common dysosma leaf, obtains corresponding powder after being crushed respectively；

Step (b)：The powder is mixed with the water of 5-15 times of weight respectively, is extracted, obtains mixed liquor；The extraction temperature Spend for 60-100 DEG C, when the extraction time is 1-10 small, the extracting times are 3-7 times；

Step (c)：The mixed liquor is filtered, obtains filtrate；

8. preparation method according to claim 6, it is characterised in that when chemical solvent is nonaqueous solvents, the chemistry Solvent extraction method includes the following steps：

Step (B)：The powder is mixed with the alcohol of 8-20 times of weight respectively, is extracted, obtains mixed liquor；The extraction temperature Spend for 55-85 DEG C, when the extraction time is 1-6 small, the extracting times are 2-5 times；

Step (C)：The mixed liquor is filtered, obtains filtrate；

9. as claim 1-5 any one of them composition of plant extracts is preparing treatment and/or prevention of cardiovascular disease Medicine in application.

10. a kind for the treatment of and/or the medicine of prevention of cardiovascular disease, it is characterised in that including described in claim any one of 1-5 Plant extracts and pharmaceutically acceptable carrier.