CN108938858A - A kind of activating microcirculation and removing stasis medicinal plaster - Google Patents
A kind of activating microcirculation and removing stasis medicinal plaster Download PDFInfo
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- CN108938858A CN108938858A CN201811010186.3A CN201811010186A CN108938858A CN 108938858 A CN108938858 A CN 108938858A CN 201811010186 A CN201811010186 A CN 201811010186A CN 108938858 A CN108938858 A CN 108938858A
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
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- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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Abstract
The invention discloses a kind of activating microcirculation and removing stasis medicinal plaster, including following raw materials: Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae, borneol, litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil, pollen extract, Sodium Aescinate, albiflorin, gypsum.The present invention is according to traditional Chinese medical theory formula, each drug coordinated, strengthens the body resistance to consolidate the constitution, Eradicates trembles with fear dehumidifying, warming and activating meridian, activating microcirculation and removing stasis medicinal and analgesic, is applied with use, safe ready has no toxic side effect.Compared with prior art, the effect of activating microcirculation and removing stasis medicinal plaster of the invention, effective component can be rapidly permeated into and is absorbed by the skin, realization activating microcirculation and removing stasis medicinal, swelling and pain relieving；Meanwhile improvement skin environment, pore is dredged, skin barrier function is improved, repairs impaired skin, has effects that anti-oxidant, removing free radical.
Description
Technical field
The present invention relates to a kind of activating microcirculation and removing stasis medicinal plaster.
Background technique
Traumatic injury refers to people because of the soft tissue injury caused by the reasons such as falling, beating, touch, crack between the teeth, with swelling, pain for main table
It is existing.Chinese traditional treatment traumatic injury has thousands of years history, and ancient " traumatic injury " is referred to as the introduction of all wounds, mostly because of external force,
Or it overexerts and causes in the case where itself fault.Chinese medicine hurts all muscles and bones because of caused by external force in human body
Damage, extravasated blood swelling and pain, derangement of Qi and blood, blockage of main and collateral channels are impaired etc. down to internal organs, are referred to as traumatic injury.
For a long time, furuncle, traumatic injury are treated mostly based on massage, hot compress, west plaster, but there are physical therapy times
Length, slow effect, patient endure the drawbacks such as pain torment to the fullest extent for a long time, and certain anti-inflammatory drugs and promoting blood circulation class drug are hormone medicine, right
Body is irritant, and long-term use can generate tolerance and certain side effect.
Plaster is one of main method of external treatment with Chinese medicine, as one piece of rarity of my Chinese nation, is played always for many years
Irreplaceable role.Practice was continued to use by 1,100, sufficiently proves that plaster has " easy to use, cheap, effect
Rapidly, significant in efficacy " the advantages that.
Since plaster is directly applied to body surface, and the most smell of drug for making paste is denseer, interior by infiltrating through skin
Transmit scriptures network, internal organs, the effects of it is wet to play regulating the qi flowing in the channels blood, degrading the channel, cold dispelling, pain of reducing swelling, therefore plaster use scope is extensive, be easy to by
People receive.The present invention provides a kind of activating microcirculation and removing stasis medicinal plaster, and effective component can be rapidly permeated into and is absorbed by the skin, and realizes promoting blood circulationization
The effect of stasis of blood, swelling and pain relieving；Meanwhile improving skin environment, pore is dredged, skin barrier function is improved, repairs impaired skin, tool
There is the effect of anti-oxidant, removing free radical.
Summary of the invention
The purpose of the present invention is to provide a kind of activating microcirculation and removing stasis medicinal plaster.
Specific technical solution is as follows:
A kind of activating microcirculation and removing stasis medicinal plaster, including following raw materials are prepared: Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis,
Motherwort, Pollen Typhae, borneol, gypsum.
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 50~75 portions of Radix Notoginseng, 25~38 parts of rivers
Vault, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 portions of motherworts, 6~20 parts
Pollen Typhae, 4~8 parts of borneols, 140~270 parts of gypsum.
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 50~75 portions of Radix Notoginseng, 25~38 parts of rivers
Vault, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 portions of motherworts, 6~20 parts
Pollen Typhae, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 140~270 parts of gypsum.
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 50~75 portions of Radix Notoginseng, 25~38 parts of rivers
Vault, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 portions of motherworts, 6~20 parts
Pollen Typhae, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 2-8 parts of pollen extracts,
140~270 parts of gypsum.
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 50~75 portions of Radix Notoginseng, 25~38 parts of rivers
Vault, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 portions of motherworts, 6~20 parts
Pollen Typhae, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 2-8 parts of pollen extracts,
0.2-3 parts of Sodium Aescinates and/or albiflorin, 140~270 parts of gypsum.
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 50~75 portions of Radix Notoginseng, 25~38 parts of rivers
Vault, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 portions of motherworts, 6~20 parts
Pollen Typhae, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 2-8 parts of pollen extracts,
The mixture of 0.2-3 parts of Sodium Aescinates and albiflorin, 140~270 parts of gypsum；The Sodium Aescinate and peony lactone
The mass ratio of glycosides is (1-3): (1-3).
Preferably, the pollen extract the preparation method is as follows: by 5-8g pollen carry out supercritical carbon dioxide extracting,
Extracting pressure is 25-35MPa, and extraction temperature is 45-55 DEG C, and extraction time is 2-4 hours, carbon dioxide flow rate 40-50L/
H, I temperature of separating still are 40-50 DEG C, pressure 10-15MPa, and II temperature of separating still is 25-35 DEG C, pressure 5-8MPa, are collected
Supercritical extract to get arrive pollen extract.
Preferably, the pollen is Schisandra chinensis pollen.
Schisandra chinensis pollen contains a variety of volatile oil, can enhance the fragrance of essential oil, and calm nerves have and calm the nerves, is anti-oxidant, disappearing
Scorching, antibacterial effect.
Litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil have the function of good tranquilizing the mind, anti-oxidant, antiphlogistic antibacterial.
Sodium Aescinate is the soap extracted from the dry mature seed of Hippocastanaceae plant buckeye (Aesculi)
Glycosides sodium salt, modern pharmacology research show it with good pharmacological activity: having very strong anti-inflammatory, anti-transudation；Subtract
Formation that is light and eliminating oedema or hemotoncus；Antioxidant radical and have the function of neuroprotection.Clinically it is mainly used for treatment wound
Wound or perform the operation caused by swelling, brain edema, venous return obstacle disease, while find to pulmonary heart disease, tumour, anal canal edema,
A variety of diseases such as facial neuritis and I type nephrotic syndrome also have a good effect.
A kind of preparation method of activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Obtain Chinese medicine coarse powder to 80~300 mesh, by Chinese medicine coarse powder be added to 5~10 times of Chinese medicine coarse powder weight mass fraction be 60~
In 80% ethanol water, it is stirred at reflux 1.5~4h of extraction at 70~85 DEG C, filters, reduction vaporization to relative density is
1.15~1.22, obtain paste extract；
S2 by paste extract, borneol, litsea citrate oil (if there is), Fructus Forsythiae oil (if there is), Rhizoma Acori Graminei oil (if there is),
Pollen extract (if there is), Sodium Aescinate (if there is), albiflorin (if there is), gypsum are uniformly mixed, and are obtained
To activating microcirculation and removing stasis medicinal plaster.
The present invention is according to traditional Chinese medical theory formula, each drug coordinated, strengthen the body resistance to consolidate the constitution, Eradicates tremble with fear dehumidifying, warming and activating meridian,
The effect of activating microcirculation and removing stasis medicinal and analgesic, is applied with and uses, and safe ready has no toxic side effect.
The present invention provides a kind of activating microcirculation and removing stasis medicinal plaster, and effective component can be rapidly permeated into and is absorbed by the skin, and realizes activating microcirculation and removing stasis medicinal,
The effect of swelling and pain relieving；Meanwhile improving skin environment, pore is dredged, skin barrier function is improved, impaired skin is repaired, has
It is anti-oxidant, remove free radical the effect of.
On the basis of common knowledge of the art, above-mentioned each optimum condition, can be each preferably to get the present invention in any combination
Embodiment.
Specific embodiment
The present invention is further illustrated below by the mode of embodiment, but does not therefore limit the present invention to the reality
It applies among a range.In the following examples, the experimental methods for specific conditions are not specified, according to conventional methods and conditions, or according to quotient
The selection of product specification.
Embodiment 1
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 62 portions of Radix Notoginseng, 30 parts of rhizome of chuanxiongs, 18 parts
Safflower, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of olibanums, 15 parts of Radix Angelicae Sinensis, 10 portions of motherworts, 8 parts of Pollen Typhaes, 5 parts of borneols, 173 parts of gypsum.
The preparation method of above-mentioned activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Chinese medicine coarse powder is obtained to 300 mesh, it is water-soluble that Chinese medicine coarse powder is added to the ethyl alcohol that the mass fraction of 8 times of Chinese medicine coarse powder weight is 75%
It in liquid, is stirred at reflux at 80 DEG C and extracts 3h, the paste extract for being 1.2 to relative density is evaporated under reduced pressure in filtering；
Paste extract, borneol, gypsum are uniformly mixed by S2, obtain activating microcirculation and removing stasis medicinal plaster.
Embodiment 2
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 62 portions of Radix Notoginseng, 30 parts of rhizome of chuanxiongs, 18 parts
Safflower, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of olibanums, 15 parts of Radix Angelicae Sinensis, 10 portions of motherworts, 8 parts of Pollen Typhaes, 5 parts of borneols, 8 portions of litsea citrate oils, 8 parts
Fructus Forsythiae oil, 8 parts of Rhizoma Acori Graminei oils, 173 parts of gypsum.
The preparation method of above-mentioned activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Chinese medicine coarse powder is obtained to 300 mesh, it is water-soluble that Chinese medicine coarse powder is added to the ethyl alcohol that the mass fraction of 8 times of Chinese medicine coarse powder weight is 75%
It in liquid, is stirred at reflux at 80 DEG C and extracts 3h, the paste extract for being 1.2 to relative density is evaporated under reduced pressure in filtering；
Paste extract, borneol, litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil, gypsum are uniformly mixed by S2, are lived
Blood stasis-resolving plaster.
Embodiment 3
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 62 portions of Radix Notoginseng, 30 parts of rhizome of chuanxiongs, 18 parts
Safflower, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of olibanums, 15 parts of Radix Angelicae Sinensis, 10 portions of motherworts, 8 parts of Pollen Typhaes, 5 parts of borneols, 8 portions of litsea citrate oils, 8 parts
Fructus Forsythiae oil, 8 parts of Rhizoma Acori Graminei oils, 5 parts of Schisandra chinensis pollen extracts, 173 parts of gypsum.
The Schisandra chinensis pollen extract the preparation method is as follows: by 6g Schisandra chinensis pollen carry out supercritical carbon dioxide extraction
It takes, extracting pressure 30MPa, extraction temperature is 50 DEG C, and extraction time is 3 hours, carbon dioxide flow rate 45L/h, separating still I
Temperature is 45 DEG C, pressure 12MPa, and II temperature of separating still is 30 DEG C, pressure 6MPa, collects supercritical extract to get arriving
Schisandra chinensis pollen extract.
The preparation method of above-mentioned activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Chinese medicine coarse powder is obtained to 300 mesh, it is water-soluble that Chinese medicine coarse powder is added to the ethyl alcohol that the mass fraction of 8 times of Chinese medicine coarse powder weight is 75%
It in liquid, is stirred at reflux at 80 DEG C and extracts 3h, the paste extract for being 1.2 to relative density is evaporated under reduced pressure in filtering；
S2 stirs paste extract, borneol, litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil, Schisandra chinensis pollen extract, gypsum
It mixes uniformly mixed, obtains activating microcirculation and removing stasis medicinal plaster.
Embodiment 4
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 62 portions of Radix Notoginseng, 30 parts of rhizome of chuanxiongs, 18 parts
Safflower, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of olibanums, 15 parts of Radix Angelicae Sinensis, 10 portions of motherworts, 8 parts of Pollen Typhaes, 5 parts of borneols, 8 portions of litsea citrate oils, 8 parts
Fructus Forsythiae oil, 8 parts of Rhizoma Acori Graminei oils, 5 parts of Schisandra chinensis pollen extracts, 1.5 parts of Sodium Aescinates, 173 parts of gypsum.
The Schisandra chinensis pollen extract the preparation method is as follows: by 6g Schisandra chinensis pollen carry out supercritical carbon dioxide extraction
It takes, extracting pressure 30MPa, extraction temperature is 50 DEG C, and extraction time is 3 hours, carbon dioxide flow rate 45L/h, separating still I
Temperature is 45 DEG C, pressure 12MPa, and II temperature of separating still is 30 DEG C, pressure 6MPa, collects supercritical extract to get arriving
Schisandra chinensis pollen extract.
The preparation method of above-mentioned activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Chinese medicine coarse powder is obtained to 300 mesh, it is water-soluble that Chinese medicine coarse powder is added to the ethyl alcohol that the mass fraction of 8 times of Chinese medicine coarse powder weight is 75%
It in liquid, is stirred at reflux at 80 DEG C and extracts 3h, the paste extract for being 1.2 to relative density is evaporated under reduced pressure in filtering；
S2 is by paste extract, borneol, litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil, Schisandra chinensis pollen extract, seven leaf soaps
Glycosides sodium, gypsum are uniformly mixed, and obtain activating microcirculation and removing stasis medicinal plaster.
Embodiment 5
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 62 portions of Radix Notoginseng, 30 parts of rhizome of chuanxiongs, 18 parts
Safflower, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of olibanums, 15 parts of Radix Angelicae Sinensis, 10 portions of motherworts, 8 parts of Pollen Typhaes, 5 parts of borneols, 8 portions of litsea citrate oils, 8 parts
Fructus Forsythiae oil, 8 parts of Rhizoma Acori Graminei oils, 5 parts of Schisandra chinensis pollen extracts, 1.5 parts of albiflorins, 173 parts of gypsum.
The Schisandra chinensis pollen extract the preparation method is as follows: by 6g Schisandra chinensis pollen carry out supercritical carbon dioxide extraction
It takes, extracting pressure 30MPa, extraction temperature is 50 DEG C, and extraction time is 3 hours, carbon dioxide flow rate 45L/h, separating still I
Temperature is 45 DEG C, pressure 12MPa, and II temperature of separating still is 30 DEG C, pressure 6MPa, collects supercritical extract to get arriving
Schisandra chinensis pollen extract.
The preparation method of above-mentioned activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Chinese medicine coarse powder is obtained to 300 mesh, it is water-soluble that Chinese medicine coarse powder is added to the ethyl alcohol that the mass fraction of 8 times of Chinese medicine coarse powder weight is 75%
It in liquid, is stirred at reflux at 80 DEG C and extracts 3h, the paste extract for being 1.2 to relative density is evaporated under reduced pressure in filtering；
S2 will be in paste extract, borneol, litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil, Schisandra chinensis pollen extract, Chinese herbaceous peony
Ester glycosides, gypsum are uniformly mixed, and obtain activating microcirculation and removing stasis medicinal plaster.
Embodiment 6
A kind of activating microcirculation and removing stasis medicinal plaster, the raw material including following weight parts are prepared: 62 portions of Radix Notoginseng, 30 parts of rhizome of chuanxiongs, 18 parts
Safflower, 15 parts of Radix Salviae Miltiorrhizaes, 15 parts of olibanums, 15 parts of Radix Angelicae Sinensis, 10 portions of motherworts, 8 parts of Pollen Typhaes, 5 parts of borneols, 8 portions of litsea citrate oils, 8 parts
Fructus Forsythiae oil, 8 parts of Rhizoma Acori Graminei oils, 5 parts of Schisandra chinensis pollen extracts, 0.75 part of Sodium Aescinate, 0.75 part of albiflorin, 173
Part gypsum.
The Schisandra chinensis pollen extract the preparation method is as follows: by 6g Schisandra chinensis pollen carry out supercritical carbon dioxide extraction
It takes, extracting pressure 30MPa, extraction temperature is 50 DEG C, and extraction time is 3 hours, carbon dioxide flow rate 45L/h, separating still I
Temperature is 45 DEG C, pressure 12MPa, and II temperature of separating still is 30 DEG C, pressure 6MPa, collects supercritical extract to get arriving
Schisandra chinensis pollen extract.
The preparation method of above-mentioned activating microcirculation and removing stasis medicinal plaster, comprising the following steps:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed
Chinese medicine coarse powder is obtained to 300 mesh, it is water-soluble that Chinese medicine coarse powder is added to the ethyl alcohol that the mass fraction of 8 times of Chinese medicine coarse powder weight is 75%
It in liquid, is stirred at reflux at 80 DEG C and extracts 3h, the paste extract for being 1.2 to relative density is evaporated under reduced pressure in filtering；
S2 is by paste extract, borneol, litsea citrate oil, Fructus Forsythiae oil, Rhizoma Acori Graminei oil, Schisandra chinensis pollen extract, seven leaf soaps
Glycosides sodium, albiflorin, gypsum are uniformly mixed, and obtain activating microcirculation and removing stasis medicinal plaster.
Primary raw material used is as follows in embodiment:
Chinese medicine material Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae believe remote Chinese medicine purchased from Bozhou City
Science and Technology Ltd..Borneol, CAS 507-70-0.Gypsum, 200 mesh of partial size, often rich medicine company sells Co., Ltd to Bozhou City.Five
Taste pollen: the pollen of magnoliaceae schisandra Schisandra chinensis (Turcz.) Baill..Litsea citrate oil:
CAS:68855-99-2, Shanghai ShuaiSun Industrial Co., Ltd., product number: SS000708.Fructus Forsythiae oil: CAS:68917-49-7,
Shanghai ShuaiSun Industrial Co., Ltd., product number: SS000612.Rhizoma Acori Graminei oil: CAS:91745-11-8, the handsome limited public affairs of Son industry
Department, product number: SS000589.Sodium Aescinate: CAS:20977-05-3, ShuaiSun Industrial Co., Ltd., product number:
SS005987.Albiflorin: CAS:39011-90-0, ShuaiSun Industrial Co., Ltd., product number: SS005992.
The clinical observation experiment of plaster treatment soft tissue injury
Test method: every group of test group randomly selects 50 soft tissue injury patients respectively, tests 6 groups of component, every component
Activating microcirculation and removing stasis medicinal plaster in other Examples 1 to 6 spreads on affected part after pico- heating and softening, and each topical application of drug of test group uses 12h,
It applies 7 days altogether, clinical observation result is as shown in table 1.
1 soft tissue injury therapeutic effect table of table
| It cures | It is effective | Effectively | In vain | |
| Embodiment 1 | 30 | 9 | 6 | 5 |
| Embodiment 2 | 33 | 9 | 5 | 3 |
| Embodiment 3 | 36 | 7 | 5 | 2 |
| Embodiment 4 | 41 | 7 | 2 | 0 |
| Embodiment 5 | 42 | 6 | 2 | 0 |
| Embodiment 6 | 46 | 3 | 1 | 0 |
The test of DPPH elimination effect:
The ability for removing DPPH free radical to the activating microcirculation and removing stasis medicinal plaster of embodiment 4-6 is tested: by activating microcirculation and removing stasis medicinal plaster
It in the ethanol water that the volume fraction for being added to its 8 times of weight is 95%, is uniformly mixed, is filtered, obtained with 800 mesh grenadines
The filtrate arrived is sample solution；Into the quartz colorimetric utensil of 1cm be added sample solution 2.0mL and 2.0mL molar concentration be 1.0 ×
104The DPPH solution of mol/L, after mixing dark place place 30 minutes, using volume fraction be 95% ethanol water as
Reference solution measures the light absorption value A at 517nm；It is 95% that same method, which measures sample solution 2.0mL and 2.0mL volume fraction,
Light absorption value Ao of the ethanol water mixed liquor at 517nm；Measuring 2.0mL molar concentration again is 1.0 × 104Mol/L's
Light absorption value A1 of the ethanol water mixed liquor that DPPH solution and 2.0mL volume fraction are 95% at 517nm, by following equation
Calculate inhibiting rate: clearance rate (%)={ 1- (A-Ao)/A1 } × 100.Test result is shown in Table 2.
Table 3:DPPH elimination effect test result table
| Clearance rate (%) | |
| Embodiment 4 | 54.3 |
| Embodiment 5 | 56.9 |
| Embodiment 6 | 61.4 |
Activating microcirculation and removing stasis medicinal plaster of the invention, effective component can be rapidly permeated into and is absorbed by the skin, and realize that activating microcirculation and removing stasis medicinal, detumescence stop
The effect of pain；Meanwhile improve skin environment, dredge pore, improve skin barrier function, repair impaired skin, have it is anti-oxidant,
The effect of removing free radical.
Skin sensibiligen test:
By 20 Kunming small white mouses, SPF grades, 150 ± 10g of weight, half male and half female pushes away tested small white mouse electricity consumption before administration
Cutting along vertebra two sides removal gross area is 3 × 3cm, and whether the epilating area for observing small white mouse afterwards for 24 hours is damaged because of depilation,
If skin injury, the experiment of intact skin group cannot function as；
By 20 small white mouses with 800# fine sandpaper by epilating area skin tears, not hurt corium, slight oozing of blood is standard,
Blank control group 10, administration group 10；
Activating microcirculation and removing stasis medicinal plaster prepared by the embodiment 6 of 2g removes plaster after coating 24 hours, is 0.9% with concentration
Sodium chloride solution cleans medicine-feeding part, when then continuing to raise according to conventinal breeding method, while recording toxicity appearing and subsiding
Between, removing is first point of observation by the 1h of drug, and later in 8h, for 24 hours, 48h is observed and recorded respectively, if malicious after 48h
Property occur, then continue to observe and record.Pay attention to the red and swollen degree in the coating region of small white mouse, hair color, weight, the change of eyes and mucous membrane
Change, the behavior expressions such as four limbs activity；
By observation, the basic indifference of skin gloss and control group in coating region, small white mouse activity freely, eyes and viscous
Film is without exception, and changes of weight keeps in the reasonable scope, without mice dying, illustrating that liquid adhesive bandage of the invention does not have skin
Skin acute toxic reaction.
The preferred embodiment of the present invention has been described in detail above.It should be appreciated that those skilled in the art without
It needs creative work according to the present invention can conceive and makes many modifications and variations.Therefore, all technologies in the art
Personnel are available by logical analysis, reasoning, or a limited experiment on the basis of existing technology under this invention's idea
Technical solution, all should be within the scope of protection determined by the claims.
Claims (8)
1. a kind of activating microcirculation and removing stasis medicinal plaster, which is characterized in that be prepared including following raw materials: Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, cream
Perfume, Radix Angelicae Sinensis, motherwort, Pollen Typhae, borneol, gypsum.
2. a kind of activating microcirculation and removing stasis medicinal plaster, which is characterized in that the raw material including following weight parts is prepared: 50~75 portions of Radix Notoginseng,
25~38 parts of rhizome of chuanxiongs, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 parts of benefits are female
Grass, 6~20 parts of Pollen Typhaes, 4~8 parts of borneols, 140~270 parts of gypsum.
3. a kind of activating microcirculation and removing stasis medicinal plaster, which is characterized in that the raw material including following weight parts is prepared: 50~75 portions of Radix Notoginseng,
25~38 parts of rhizome of chuanxiongs, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 parts of benefits are female
Grass, 6~20 parts of Pollen Typhaes, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 140~
270 parts of gypsum.
4. a kind of activating microcirculation and removing stasis medicinal plaster, which is characterized in that the raw material including following weight parts is prepared: 50~75 portions of Radix Notoginseng,
25~38 parts of rhizome of chuanxiongs, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 parts of benefits are female
Grass, 6~20 parts of Pollen Typhaes, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 2-8 parts
Pollen extract, 140~270 parts of gypsum.
5. a kind of activating microcirculation and removing stasis medicinal plaster, which is characterized in that the raw material including following weight parts is prepared: 50~75 portions of Radix Notoginseng,
25~38 parts of rhizome of chuanxiongs, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 parts of benefits are female
Grass, 6~20 parts of Pollen Typhaes, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 2-8 parts
Pollen extract, 0.2-3 part Sodium Aescinate and/or albiflorin, 140~270 parts of gypsum.
6. a kind of activating microcirculation and removing stasis medicinal plaster, which is characterized in that the raw material including following weight parts is prepared: 50~75 portions of Radix Notoginseng,
25~38 parts of rhizome of chuanxiongs, 15~25 parts of safflowers, 10~30 parts of Radix Salviae Miltiorrhizaes, 10~30 parts of olibanums, 10~20 parts of Radix Angelicae Sinensis, 8~16 parts of benefits are female
Grass, 6~20 parts of Pollen Typhaes, 4~8 parts of borneols, 5-10 portions of litsea citrate oils, 5-10 parts of Fructus Forsythiae oils, 5-10 parts of Rhizoma Acori Graminei oils, 2-8 parts
The mixture of pollen extract, 0.2-3 part Sodium Aescinate and albiflorin, 140~270 parts of gypsum；The otoginsenoside
The mass ratio of sodium and albiflorin is (1-3): (1-3).
7. such as the described in any item activating microcirculation and removing stasis medicinal plaster of claim 4~6, which is characterized in that the preparation of the pollen extract
Method is as follows: 5-8g pollen is carried out supercritical carbon dioxide extracting, extracting pressure 25-35MPa, extraction temperature 45-55
DEG C, extraction time is 2-4 hours, carbon dioxide flow rate 40-50L/h, and I temperature of separating still is 40-50 DEG C, pressure 10-
15MPa, II temperature of separating still are 25-35 DEG C, pressure 5-8MPa, collect supercritical extract to get pollen extract is arrived.
8. the preparation method of activating microcirculation and removing stasis medicinal plaster as described in any one of claims 1 to 7, which is characterized in that including following step
It is rapid:
S1 weighs raw material by weight, and Radix Notoginseng, rhizome of chuanxiong, safflower, Radix Salviae Miltiorrhizae, olibanum, Radix Angelicae Sinensis, motherwort, Pollen Typhae are crushed to 80
~300 mesh obtain Chinese medicine coarse powder, are 60~80% by the mass fraction that Chinese medicine coarse powder is added to 5~10 times of Chinese medicine coarse powder weight
In ethanol water, 1.5~4h of extraction is stirred at reflux at 70~85 DEG C, filter, be evaporated under reduced pressure to relative density be 1.15~
1.22, obtain paste extract；
S2 is by paste extract, borneol, litsea citrate oil (if there is), Fructus Forsythiae oil (if there is), Rhizoma Acori Graminei oil (if there is), pollen
Extract (if there is), Sodium Aescinate (if there is), albiflorin (if there is), gypsum are uniformly mixed, and are lived
Blood stasis-resolving plaster.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109966465A (en) * | 2019-04-23 | 2019-07-05 | 杨峰 | A kind of drug and preparation method thereof for treating cervical vertebra |
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| CN103142938A (en) * | 2013-03-27 | 2013-06-12 | 赵振德 | Plaster for treating traumatic injury and fracture |
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Application publication date: 20181207 |