CN106138241A - A kind of Chinese medicine composition of relieving itching and eliminating swelling and preparation method thereof after mosquito bite - Google Patents
A kind of Chinese medicine composition of relieving itching and eliminating swelling and preparation method thereof after mosquito bite Download PDFInfo
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- CN106138241A CN106138241A CN201610700793.7A CN201610700793A CN106138241A CN 106138241 A CN106138241 A CN 106138241A CN 201610700793 A CN201610700793 A CN 201610700793A CN 106138241 A CN106138241 A CN 106138241A
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Abstract
The invention discloses a kind of Chinese medicine composition of relieving itching and eliminating swelling and preparation method thereof after mosquito bite, it is made up of the crude drug of following parts by weight: the Radix Astragali 30～80 parts, Calculus Bovis 1～10 parts, Herba Scutellariae Barbatae 20～60 parts, Radix Glycyrrhizae 30～60 parts, the Fructus Kochiae 30～70 parts, Radix Sophorae Flavescentis 20～60 parts, Cortex Cinnamomi 30～60 parts, Flos Caryophylli 20～60 parts.The Chinese medicine composition scientific formula that the present invention provides, the Chinese medicine preparation being prepared from and floral water, have no side effect, use the formula of pure natural, with strong points.The preparation for treating mosquito bite total effective rates 95% such as floral water prepared by Chinese medicine composition of the present invention, averagely smear pruritus, the burning pain symptom that can eliminate mosquito bite and cause 5 minutes, within 30 minutes, can eliminate redness, and curative effect is reliable, quickly.Adult, child all can use, safe and reliable.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite
Thing and preparation method thereof.
Background technology
Mosquito spp Insecta Diptera Dulicidae, is a kind of fine winged insect with sucking mouth parts, and the female mosquito sucked blood is to step on
The vector of other pathogen such as leather heat, malaria, yellow fever, filaricide, Japanese encephalitis.Mosquito species is a lot, it is known that the world
On have kind more than 3000, China has been found that more than 300 plant, mainly Anopheles sinensis Anopheleshyrcanus sinensis, light color
Culex Culex pipiens pallens and Aedes albopictus Aedes albopictus tri-class.
Mosquito bite dermatitis (Mosquito-bite dermatitis, MBD), is the allergic dermatitis caused by mosquito bite
Disease, for the main Types of insect dermatitis.Mosquito stabs skin by its mouthpart, and its saliva or venom invade skin, enter human body
Causing inflammatory reaction after skin, redness, burning pain occur, scratch where it itches, it is serious anti-that one or two people local produces bulla, hemorrhagic necrosis etc.
Should.
Summer is difficult to avoid that by mosquito bite, but the redness, burning pain and the Itching conditions that are occurred after mosquito bite
Quickly eliminate and remain a difficult problem.The medicine being currently used for mosquito bite relieving itching and eliminating swelling mostly is antiallergic, hormones Western medicine, such as benzene
Sea Lamine, dermatitis equality, life-time service not only can develop immunity to drugs, it is also possible to makes wound surface pigmentation, and then causes wound surface
The side effect such as atrophoderma, secondary infection, child need to be cautious use of.Or neutralize with alkaline matter, such as suds, sodium bicarbonate or ammonia
The acid venom of mosquito alleviates redness, cleans, with floral water etc., the place of biting simultaneously and comes antipruritic, but effect is the most inconspicuous.
Floral water in the market is various, but its traditional raw material is dimethyl phthalate, ethanol, Mentholum, Borneolum Syntheticum, Moschus moschiferous
Rhizoma et radix valerianae phenol, Camphora, essence, ethanol and deionized water, in addition to there is refrigerant, to dispel miliaria function, the worm that mosquito bite is caused
Sting dermatitis effects little.Dimethyl phthalate contained by floral water has certain toxicity, in use, people by digestive tract,
Respiratory tract absorbs the dimethyl phthalate of part, can not only induce the diseases such as asthma, and life-time service also can carcinogenic, teratogenesis.Some liquid distilled from honeysuckle flowers or lotus leaves
Water, in order to reach the effect of antiinflammatory, generally adds salicylic acid compounds, but salicylic acid compounds permeability is too high, not only
Diazolidinyl Urea, also can make xerosis cutis.Additionally, many floral water containing Mentholum, often cause people's skin
Irritability is reacted.
The scytitis that mosquito bite causes, belongs to " evil insect stings " category in Chinese medicine.Motherland's medical science thinks to be venom
Invading skin, injure channels, channels stasis blocking, QI-blood circulation is smooth, caused by strongly fragrant and heat-transformation.Main pathological change is poison, the stasis of blood, heat.
It is the basic rule for the treatment of that treatment is worked as with the anti-heresy of consolidating superficial resistance, heat-clearing and toxic substances removing, disperse blood stasis and dredge collateral, dispelling wind for relieving itching.
Documents: a kind of Chinese medicine composition, preparation, floral water and using method thereof (number of patent application:
201210315409.3) patent of invention discloses a kind of pure natural plant flowers Chinese medicine composition for mosquito-expelling and antipruritic, system
Agent and floral water, and using method.This Chinese medicine composition include Radix Salviae Miltiorrhizae, Herba Menthae, Calculus Bovis, Stigma Croci, Flos Lonicerae, Flos Chrysanthemi Indici,
Cortex Dictamni, the Radix Astragali, Flos Caryophylli, Radix Sophorae Flavescentis, Flos Campsis, Herba Portulacae etc., Chinese medicine preparation that thus compositions is prepared from and floral water master
Mosquito-expelling and antipruritic to be used for.This invention is applied to mosquito bite patient, and average 8 minutes antipruritic, within 1 day, could subside a swelling, antipruritic and detumescence
Time is longer, it is therefore necessary to invention one detumescence and antipruritic effect more preferably Chinese medicine composition.
Summary of the invention
Goal of the invention: present invention aim to address the deficiencies in the prior art, it is provided that one is efficiently and safely for mosquito
Chinese medicine composition biting repellent antipruritic and preparation method thereof.Prescription of the present invention on the basis of existing technology, by a large amount of real
Testing screening flavour of a drug, choose Herba Scutellariae Barbatae, Radix Glycyrrhizae, the Fructus Kochiae, Cortex Cinnamomi are raw material, full side is the section carried out based on Chinese medical theory
Learn prescription rather than the simple combination of effect flavour of a drug.The anti-heresy of Radix Astragali consolidating superficial resistance in side, for monarch drug；Calculus Bovis and Herba Scutellariae Barbatae heat-clearing and toxic substances removing,
The Fructus Kochiae and Radix Sophorae Flavescentis antipyretic and itching-stopping, be ministerial drug altogether；Cortex Cinnamomi and Flos Caryophylli fragrance are walked to alter, and are adjuvant drug altogether, and Radix Glycyrrhizae tool solves hundred poison of drug, as
Make medicine.Complete square heat-clearing and toxic substances removing, repellent antipruritic.And the present invention uses different extracting method according to prescription each medical material character and adopts
With the techniques such as purification by macroporous resin, the Chinese medicine preparation being prepared from and floral water in the quick repellent antipruritic side for mosquito bite
Face effect is notable, test result indicate that: averagely smear pruritus, the burning pain symptom that can eliminate mosquito bite and cause 5 minutes, 30 points
Clock can eliminate redness, have rapid-action, have no side effect, the advantage such as easy to use.
Technical scheme: in order to realize object above, the technical scheme that the present invention takes is:
A kind of Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it prepares by the crude drug of following parts by weight:
The Radix Astragali 30～80 parts, Calculus Bovis 1～10 parts, Herba Scutellariae Barbatae 20～60 parts, Radix Glycyrrhizae 30～60 parts, the Fructus Kochiae 30～70 parts,
Radix Sophorae Flavescentis 20～60 parts, Cortex Cinnamomi 30～60 parts, Flos Caryophylli 20～60 parts.
Wherein Calculus Bovis can replace with artificial Calculus Bovis or In vitro cultured Calculus Bovis.
Preferably, the above-described Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is by following heavy
The crude drug of amount number prepares:
The Radix Astragali 50 parts, Calculus Bovis 6 parts, Herba Scutellariae Barbatae 40 parts, 50 parts of Radix Glycyrrhizae, the Fructus Kochiae 50 parts, Radix Sophorae Flavescentis 40 parts, Cortex Cinnamomi 50 parts, fourth
Fragrant 50 parts.
Preferably, the above-described Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is by following heavy
The crude drug of amount number prepares:
The Radix Astragali 30 parts, Calculus Bovis 1 part, Herba Scutellariae Barbatae 20 parts, 30 parts of Radix Glycyrrhizae, the Fructus Kochiae 30 parts, Radix Sophorae Flavescentis 20 parts, Cortex Cinnamomi 30 parts, fourth
Fragrant 20 parts.
Preferably, the above-described Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is by following heavy
The crude drug of amount number prepares:
The Radix Astragali 80 parts, Calculus Bovis 10 parts, Herba Scutellariae Barbatae 60 parts, 60 parts of Radix Glycyrrhizae, the Fructus Kochiae 70 parts, Radix Sophorae Flavescentis 60 parts, Cortex Cinnamomi 60 parts, fourth
Fragrant 60 parts.
Preferably, the above-described Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, described Calculus Bovis
For natural Calculus Bovis or artificial Calculus Bovis.
The preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite of the present invention, it includes following step
Rapid:
A: take the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae by weight, is broken into the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste Chinese medicine powder slightly
Powder, adds ethanol, heating and refluxing extraction, filters, united extraction liquid, and filtrate concentrates, and obtains medicinal liquid A；
B: take the Fructus Kochiae and Radix Sophorae Flavescentis by weight, by the Fructus Kochiae and Radix Sophorae Flavescentis boiling, filters, united extraction liquid, will
Filtrate reduced in volume, is cooled to room temperature, adds ethanol, and limit edged stirs, and makes fully to mix, and stands, filters precipitate, by filtrate
Reclaiming ethanol and be concentrated into extractum, adding ethanol, heating makes extractum dissolve, and the solution left standstill after dissolving filters precipitate,
To medical liquid B；
C: upper macroporous adsorptive resins after the medical liquid B mixing that medicinal liquid A step A obtained and step B obtain, standing adsorption
After, it is washed with deionized water that to take off to eluent be colourless, discards eluent, being then eluted to eluent with low concentration C1～3 alcohol is
Light color, discards eluent, then with high concentration C1～3 alcohol eluting, collects eluent, and eluent recovered under reduced pressure removes C1～3 alcohol, dense
Contracting, obtains medicinal liquid C；
D: take Cortex Cinnamomi and Flos Caryophylli by weight, uses extraction by steam distillation, obtains extractive of volatile oil；
E: the extractive of volatile oil mixing that medicinal liquid C step C obtained and step D obtain, adds Calculus Bovis by weight,
Mixing, to obtain final product.
Preferably, the described preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, its bag
Include following steps:
Step A: take the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae by weight, is ground into the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste slightly
Powder, adds such as volumetric concentration 30%～80% ethanol, heating and refluxing extraction 1～3 times, and each ethanol volumetric usage is medical material weight
4～10 times amount, each 1～3 hour, filter and merge 1～3 extracting solution, being concentrated into 0.25～5g crude drug/mL medicinal liquid A；
Step B: take the Fructus Kochiae and Radix Sophorae Flavescentis by weight, by the Fructus Kochiae and Radix Sophorae Flavescentis boiling 1～3 times, adds water every time
Volume is 2～10 times of medical material weight, each 1～3 hour, filters and merges 1～3 extracting solution, by filtrate reduced in volume
To the 1/3～1/2 of original volume, being cooled to room temperature, add the 60%-95% ethanol of 1～3 times of volume, limit edged stirs, and makes fully
Mixing, stands 12～36 hours, filters precipitate, by filtrate recycling ethanol and to be concentrated into 50 DEG C of relative densities be 1.20～1.40
Thick shape extractum, add 20%～60% ethanol, heating makes extractum dissolve, by the solution left standstill 12 after dissolving～36 hours,
Filter precipitate, obtain medical liquid B；
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
Be colourless to eluent, discard eluent, be then 5 by concentration～the C1 of 30%～3 alcohol to be eluted to eluent be light color, discard
Eluent, then with the C1 that concentration is 40%～95%～3 alcohol eluting, collect eluent, eluent reduces pressure, and reclaims and removes C1～3
Alcohol, is concentrated into 0.5～3g crude drug/mL medicinal liquid C；
Step D: take Cortex Cinnamomi, Flos Caryophylli by weight, adds medical material weight 8～the water of 15 times of volumes, uses steam
The way of distillation is extracted, and obtains extractive of volatile oil；
Step E: the extractive of volatile oil mixing that medicinal liquid C step C obtained and step D obtain, adds by weight
Calculus Bovis, mixing, to obtain final product.
Preferably, the described preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, its bag
Include following steps:
Step A: take the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae by weight, is ground into the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste slightly
Powder, adding 8 times amount volumetric concentrations is 50% ethanol, heating and refluxing extraction 3 times, each 2 hours, filters and merges 3 extracting solution,
It is concentrated into 2g crude drug/mL medicinal liquid A, standby；
Step B: take the Fructus Kochiae and Radix Sophorae Flavescentis by weight, by the Fructus Kochiae and Radix Sophorae Flavescentis boiling 3 times, adds water volume every time
Amount is 10 times of medical material weight, each 1.5 hours, filters and merges 3 extracting solution, concentrate filtrate to the 1/ of original volume
3～1/4, it is cooled to room temperature, adds 95% ethanol of 3 times of volumes, limit edged stirs, and makes fully to mix, stands 24 hours, filter
Precipitate, by filtrate recycling ethanol and be concentrated into the thick shape extractum that 55 DEG C of relative densities are 1.30～1.35, adds volumetric concentration
50% ethanol, heating makes extractum dissolve, the solution left standstill after dissolving 24 hours, filters precipitate, obtains medical liquid B；
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
It is colourless to eluent, discards eluent, be then light color with the ethanol elution that volumetric concentration is 20% to eluent, discard and wash
De-liquid, then be the ethanol elution of 50% by volumetric concentration, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 3g
Crude drug/mL medicinal liquid C；
Step D: take Cortex Cinnamomi, Flos Caryophylli, adds the water of 10 times of volumes of medical material weight, uses extraction by steam distillation,
To extractive of volatile oil；
Step E: extractive of volatile oil mixing medicinal liquid C and step D obtained, adds Calculus Bovis, mixing, to obtain final product.
Preferably, the described preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is special
Levy and be: C1～3 alcohol described in step C are methanol, ethanol or propanol.
Preferably, the described preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is special
Levying and be, described macroporous adsorbent resin is D101, HPD100, AB-8 or X-5 macroporous adsorbent resin.
Preferably, the described preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is special
Levying and be, the Chinese medicine extract of gained adds pharmaceutically acceptable carrier, prepares Chinese medicine preparation.
Preferably, the described preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is special
Levying and be, described Chinese medicine preparation is the external preparation of liniment, ointment, gel, spray or aerosol.
Preferably, above-described a kind of preparation side of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite
Method, the Chinese medicine extract of gained adds essence, is prepared as floral water with second alcohol and water furnishing finite concentration.
Advantages of the present invention and beneficial effect:
Radix Astragali energy complement sun in Chinese medicine composition prescription of the present invention, kind benefit the four stages in the course of an epidemic febrile disease, fills space between skin and muscles, wind dispelling fortune poison, consolidating superficial resistance
Anti-heresy, for surgery man's panacea.After mosquito bite, toxin invades skin surface, and human body can occur fierce antagonism, shows as red
Swollen, burning pain, the reaction such as scratch where it itches, this is a kind of natural reaction of human body, outside being intended to the foreign bodies such as toxin are discharged health.The Radix Astragali can be bright
The aobvious this antagonism strengthening human body flesh table, helps quickly to remove toxin, has usually said " tonification " effect.Modern study
Showing, the Radix Astragali has the effect of enhancing body specific immunity and nonspecific immunity.
Calculus Bovis and Herba Scutellariae Barbatae have efficient heat clearing away, detoxify, effect of subsiding a swelling.Research shows, mosquito is stung by Herba Scutellariae Barbatae external
Wound has good detoxicating functions.
The Fructus Kochiae and Radix Sophorae Flavescentis heat clearing away, antipruritic.After mosquito bite, toxin invades body surface human body can occur fierce antagonism, table
Now reacting for redness, burning pain, scratch where it itches etc., reaction of scratching where it itches therein is extremely to make us the most joyful, especially child and infant
Skin can be scratched because of violent scratching where it itches, and secondary courses of infection.The combination of the Fructus Kochiae and Radix Sophorae Flavescentis have splendid and be exceedingly fast only
Itch effect.
Cortex Cinnamomi and Flos Caryophylli walk to alter rich in volatile oil, fragrance, have the effect promoting above Drug Percutaneous Absorption, make each medicine
Active component quickly enters skin histology, the respective effect of fast onset, reaches quickly the purpose of " antipruritic, detoxify, subside a swelling ".
Radix Glycyrrhizae has system hundred poison of drug and conciliates effect of hundred poison of drug, and in Chinese medicine compound, application can coordinating the actions of various ingredients in a prescription.Modern pharmacology
Research is pointed out, the effective ingredient of Radix Glycyrrhizae removing toxic substances is glycyrrhizin, and glycyrrhizin have adrenocortical hormone sample anti allergic reaction, can
Absorption poisonous substance, to reduce absorption, improves the body tolerance to toxicant.
To sum up, Chinese medicine composition of the present invention is with the anti-heresy of Radix Astragali consolidating superficial resistance, for monarch drug；Calculus Bovis and Herba Scutellariae Barbatae heat-clearing and toxic substances removing, Fructus Kochiae
Son and Radix Sophorae Flavescentis antipyretic and itching-stopping, be ministerial drug altogether；Cortex Cinnamomi and Flos Caryophylli fragrance are walked to alter, and are adjuvant drug altogether, and Radix Glycyrrhizae tool solves hundred poison of drug, as making
Medicine.Complete square heat-clearing and toxic substances removing, repellent antipruritic, can be used for the quick repellent antipruritic of mosquito bite.
Invent and use different extracting method according to prescription medical material character and use the techniques such as macroporous resin to be purified,
Improve the content of effective ingredient, the Chinese medicine preparation being prepared from and floral water are in the quick repellent antipruritic side for mosquito bite
Face effect is notable, have rapid-action, have no side effect, the advantage such as easy to use.Floral water of the present invention is shown through animal experiment research
Cavia porcellus itch-threshold can be significantly improved.Clinical application indicate that, floral water of the present invention treatment mosquito bite total effective rate 95%, flat
All smear 5 minutes and can eliminate the pruritus that mosquito bite causes, burning pain symptom, within 30 minutes, redness can be eliminated.And documents
Chinese medicine composition is antipruritic for average 8 minutes of mosquito bite, just detumescence in 1 day, Chinese medicine composition the most of the present invention detumescence and only
Effect of itching has the most progressive compared with documents Chinese medicine composition.
Detailed description of the invention
Be further elucidated with the present invention below in conjunction with specific embodiment, it should be understood that these embodiments be merely to illustrate the present invention and
It is not used in restriction the scope of the present invention, after having read the present invention, those skilled in the art's shape various of equal value to the present invention
The amendment of formula all falls within the application claims limited range.
Embodiment 1
1, present invention Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite
Prescription: the Radix Astragali 50 parts, Calculus Bovis 6 parts, Herba Scutellariae Barbatae 40 parts, 50 parts of Radix Glycyrrhizae, the Fructus Kochiae 50 parts, Radix Sophorae Flavescentis 40 parts, Cortex Cinnamomi 50
Part, Flos Caryophylli 50 parts.
2, the preparation process of Chinese medicine composition composition liniment:
Step A: the Radix Astragali 50 parts, 50 parts of Radix Glycyrrhizae and 40 part of three taste of Herba Scutellariae Barbatae are ground into coarse powder, add volumetric concentration 50% second
Alcohol, heating and refluxing extraction 3 times, each ethanol volumetric usage is 8 times of medical material weight, each 2 hours, filters and merge 3 times
Extracting solution, is concentrated into 1.5g crude drug/mL medicinal liquid A standby；
Step B: by the Fructus Kochiae 50 parts and 40 parts of decoction pieces boilings of Radix Sophorae Flavescentis 3 times, the volume that every time adds water is medical material weight
10 times amount, each 1.5 hours, filter and merge 3 extracting solution, concentrate filtrate to the 1/3～1/4 of original volume, cooling
To room temperature, adding 95% ethanol of 3 times of volumes, limit edged stirs, and makes fully to mix, stands 24 hours, filters precipitate, will filter
Liquid reclaims ethanol and to be concentrated into relative density be 1.30～1.35 (55 DEG C) paste, adds 50% ethanol heating and makes extractum molten
Solve, the solution left standstill after dissolving 24 hours, filter precipitate, obtain medical liquid B.
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
It is light color to eluent, discards eluent, be then light color with the ethanol elution that concentration is 20% to eluent, discard eluting
Liquid, then with the ethanol elution that concentration is 50 ethanol %, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 3g raw
Medicine/mL medicinal liquid C；
Step D: take Cortex Cinnamomi 50 parts, Flos Caryophylli 50 parts, uses 10 times amount water extraction by steam distillations, obtains volatile oil is drawn
Thing.
Step E: extractive of volatile oil mixing medicinal liquid C and step D obtained, adds Calculus Bovis 6 parts, mixing, subpackage, to obtain final product
Liniment of the present invention.
Embodiment 2
1, present invention Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite
Prescription: the Radix Astragali 30 parts, In vitro cultured Calculus Bovis 1 part, Herba Scutellariae Barbatae 20 parts, 30 parts of Radix Glycyrrhizae, the Fructus Kochiae 30 parts, Radix Sophorae Flavescentis 20
Part, Cortex Cinnamomi 30 parts, Flos Caryophylli 20 parts.
2, the preparation of Chinese medicine composition ointment of the present invention
Step A: the Radix Astragali 30 parts, 30 parts of Radix Glycyrrhizae and 20 part of three taste of Herba Scutellariae Barbatae are ground into coarse powder, add volumetric concentration 60% second
Alcohol heating and refluxing extraction 3 times, each ethanol consumption is 10 times amount, each 1.5 hours, filters and merge 3 extracting solution, concentrates
Standby to 3g crude drug/mL medicinal liquid A.
Step B: by the Fructus Kochiae 30 parts and Radix Sophorae Flavescentis 2 parts, boiling 3 times, each amount of water is 10 times amount volumes, every time
1.5 hours, filter and merge 3 extracting solution, concentrating filtrate to the 1/3～1/4 of original volume, being cooled to room temperature, adding 3
95% ethanol of times volume, limit edged stirs, makes fully to mix, stand 24 hours, filter precipitate, by filtrate recycling ethanol also
Being concentrated into relative density is 1.30～1.35 (55 DEG C) paste, adds 60% ethanol heating and makes extractum dissolve, after dissolving
Solution left standstill 24 hours, filters precipitate, obtains medical liquid B；
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
Being light color to eluent, discard eluent, being then eluted to eluent with the ethanol alcohol that concentration is 20% is light color, discards eluting
Liquid, then with the ethanol elution that concentration is 50 ethanol %, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 3g raw
Medicine/mL medicinal liquid C；
Step D: take Cortex Cinnamomi 30 parts, Flos Caryophylli 20 parts, uses 8 times amount water extraction by steam distillations, obtains volatile oil is drawn
Thing.
Step E: extractive of volatile oil mixing medicinal liquid C and step D obtained, adds Calculus Bovis 1 part, adds ethyl hydroxybenzoate 1
Part, lanoline 50 parts and vaseline are appropriate, mixing, obtain ointment of the present invention.
Embodiment 3
1, present invention Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite
Prescription: the Radix Astragali 80 parts, artificial Calculus Bovis 10 parts, Herba Scutellariae Barbatae 60 parts, 60 parts of Radix Glycyrrhizae, the Fructus Kochiae 70 parts, Radix Sophorae Flavescentis 60 parts, meat
60 parts of osmanthus, Flos Caryophylli 60 parts.
2, the preparation process of Traditional Chinese medicine composition-type spray of the present invention:
Step A: the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste are ground into coarse powder, adds 60% alcohol heating reflux extraction 3 times, often
Secondary ethanol consumption is 8 times amount, each 2 hours, filters and merges 3 extracting solution, being concentrated into 0.5g crude drug/mL medicinal liquid A.
Step B: by the Fructus Kochiae and Radix Sophorae Flavescentis decoction pieces boiling 3 times, each amount of water is 10 times amount volumes, each 2 hours,
Filter and merge 3 extracting solution, concentrating filtrate to the 1/3～1/4 of original volume, being cooled to room temperature, adding 3 times of volumes
95% ethanol, limit edged stirs, makes fully to mix, stand 24 hours, filter precipitate, by filtrate recycling ethanol and be concentrated into phase
It is 1.30～1.35 (55 DEG C) paste to density, adds 50% ethanol heating and make extractum dissolve, the solution left standstill after dissolving
24 hours, filter precipitate, obtain medical liquid B.
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
Being light color to eluent, discard eluent, being then eluted to eluent with the ethanol alcohol that concentration is 30% is light color, discards eluting
Liquid, then with the ethanol elution that concentration is 60% ethanol, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 1g raw
Medicine/mL medicinal liquid C；
Step D: take Cortex Cinnamomi, Flos Caryophylli, uses 10 times amount water extraction by steam distillations, obtains extractive of volatile oil.
Step E: extractive of volatile oil mixing medicinal liquid C and step D obtained, adds artificial Calculus Bovis 10 parts, mixes, quantitatively
It is divided in spray bottle, loads onto manual pump and i.e. obtain spray of the present invention.
Embodiment 4
The preparation (one) of floral water of the present invention,
Prescription: the Radix Astragali 50 parts, artificial Calculus Bovis 6 parts, Herba Scutellariae Barbatae 40 parts, 50 parts of Radix Glycyrrhizae, the Fructus Kochiae 50 parts, Radix Sophorae Flavescentis 40 parts, meat
50 parts of osmanthus, Flos Caryophylli 50 parts.
Preparation process:
Step A: the Radix Astragali 50 parts, 50 parts of Radix Glycyrrhizae and 40 part of three taste of Herba Scutellariae Barbatae are ground into coarse powder, add 30% ethanol and heat back
Stream extracts 3 times, and each ethanol consumption is 10 times amount, each 2 hours, filters and merges 3 extracting solution, is concentrated into 1.5g raw
Medicine/mL medicinal liquid A is standby.
Step B: by the Fructus Kochiae 50 parts and Radix Sophorae Flavescentis decoction pieces 40 parts, boiling 3 times, each amount of water is 8 times amount volumes, often
Secondary 2 hours, filter and merge 3 extracting solution, concentrating filtrate to the 1/3～1/4 of original volume, being cooled to room temperature, adding 3
90% ethanol of times volume, limit edged stirs, makes fully to mix, stand 24 hours, filter precipitate, by filtrate recycling ethanol also
Being concentrated into relative density is 1.30～1.35 (55 DEG C) paste, adds 60% ethanol heating and makes extractum dissolve, after dissolving
Solution left standstill 24 hours, filters precipitate, obtains medical liquid B.
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
Being light color to eluent, discard eluent, being then eluted to eluent with the ethanol alcohol that concentration is 40% is light color, discards eluting
Liquid, then be the ethanol elution of 80% by concentration, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 0.5g raw
Medicine/mL medicinal liquid C；
Step D: take Cortex Cinnamomi 50 parts, Flos Caryophylli 50 parts, uses 10 times amount water extraction by steam distillations, obtains volatile oil is drawn
Thing.
Step E: medicinal liquid C and step D are obtained extractive of volatile oil mixing, add Calculus Bovis 6 parts, mixing, then add essence,
Second alcohol and water regulation concentration is also configured to required volumes of formulation, obtains floral water of the present invention.
Embodiment 5
The preparation (two) of floral water of the present invention,
Prescription: the Radix Astragali 80 parts, Calculus Bovis 10 parts, Herba Scutellariae Barbatae 60 parts, 60 parts of Radix Glycyrrhizae, the Fructus Kochiae 70 parts, Radix Sophorae Flavescentis 60 parts, Cortex Cinnamomi 60
Part, Flos Caryophylli 60 parts.
Preparation process:
Step A: the Radix Astragali 80 parts, 60 parts of Radix Glycyrrhizae and 60 part of three taste of Herba Scutellariae Barbatae are ground into coarse powder, add 55% ethanol and heat back
Stream extract 2 times, each ethanol consumption is 8 times amount, each 2 hours, filters and merges 2 extracting solution, be concentrated into 1.0g crude drug/
ML medicinal liquid A is standby.
Step B: by the Fructus Kochiae 70 parts and 60 parts of boilings of Radix Sophorae Flavescentis decoction pieces 2 times, each amount of water is 8 times amount volumes, often
Secondary 2 hours, filter and merge 2 extracting solution, concentrating filtrate to the 1/3～1/4 of original volume, being cooled to room temperature, adding 3
80% ethanol of times volume, limit edged stirs, makes fully to mix, stand 24 hours, filter precipitate, by filtrate recycling ethanol also
Being concentrated into relative density is 1.30～1.35 (55 DEG C) paste, adds 60% ethanol heating and makes extractum dissolve, after dissolving
Solution left standstill 24 hours, filters precipitate, obtains medical liquid B.
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water de-
Being light color to eluent, discard eluent, being then eluted to eluent with the ethanol alcohol that concentration is 30% is light color, discards eluting
Liquid, then be the ethanol elution of 90% by concentration, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 1.0g raw
Medicine/mL medicinal liquid C；
Step D: take Cortex Cinnamomi 60 parts, Flos Caryophylli 60 parts, uses 8 times amount water extraction by steam distillations, obtains volatile oil is drawn
Thing.
Step E: extractive of volatile oil mixing medicinal liquid C and step D obtained, adds Calculus Bovis 10 parts, mixing, then perfuming
Essence, second alcohol and water regulation concentration is also configured to required volumes of formulation, obtains floral water of the present invention.
Embodiment 6
Chinese medicine composition floral water antipruritic effect of the present invention is tested
1, test method: reference " study of tcm new drug guide ", Ministry of Public Health bureau of drug policy & administration, 2003.
2, test material: Cavia porcellus 30, male and female half and half, body weight 200-350 gram.Histamine phosphate.Positive control: certain product commercially available
Board antipruritus toilet water.Test sample: the floral water finished product of the embodiment of the present invention 4 gained.
3, experimental result
Floral water of the present invention is improved Cavia porcellus itch-threshold effect, compares with blank group and positive controls and has significantly
Sex differernce (P 0.01 or P 0.05).
The different group of table 1 causes, on histamine phosphate, the impact reacted of itching
Note: compare with blank group；△P 0.01；Compare with positive controls；* P 0.05
Embodiment 7
Chinese medicine composition floral water of the present invention treatment mosquito bite observation of curative effect
1, the object of observation and packet: experimenter 80 example.It is randomly divided into treatment group and matched group.Treatment group 40 example, male 16 examples,
Female 24 example；Age 1～55 years old.Matched group 40 example, male 14 examples, female 26 example；Age 1～60 years old.Two groups the age, sex, etc. side
Face no significant difference (P 0.05), has comparability.
2, clinical symptoms: little red pimple occurs in mosquito position of biting, red and swollen, bulge.Locally pruritus is unbearably, has burning pain sense.
3, test material
(1) test sample: floral water prepared by the embodiment of the present invention 4
(2) reference substance: the floral water that existing number of patent application 201210315409.3 embodiment 6 prepares
4, using method: treatment group and matched group use floral water of the present invention, certain brand antipruritus toilet water to be applied in respectively
Mosquito bite position, 3～4 times.
5, criterion of therapeutical effect: effective: clinical symptom disappearance within 30 minutes, red some redness disappears, locally scratchiness and heat
Pain disappears；Effective: in 60 minutes, clinical symptoms substantially disappears or substantially alleviates, red point disappears substantially, and red and swollen bulge is obvious
Reducing, locally scratchiness and burning pain sense substantially alleviate.Invalid: within 4 hours, clinical symptoms has no improvement, and red point does not disappears, red
Swollen bulge is without improving, and locally scratchiness and burning pain sense are without improving.
6, experimental result:
Result of the test shows, the floral water treatment mosquito bite total effective rate 95% that the present invention prepares, average 5 minutes
Pruritus disappears, red and swollen disappearance in 30 minutes.Matched group floral water total effective rate is 77.5%, and two groups are compared and have significant difference (P
0.05), more than test result indicate that the present invention provide prepared by Chinese medicine composition floral water treatment the red point of due to mosquito bites,
Red and swollen bulge and pruritus, burning pain sense have good curative effect, and effect is better than commercially available common floral water.Two groups of therapeutic effect compare to be seen
Table 2:
2 liang of table group treatment mosquito bite Clinical efficacy comparison
Note: compare with blank group；*P 0.05
7, safety evaluatio
(1) irritation test: present composition floral water all without skin irritation, also has no in process of the test
There are whole body or local untoward reaction.
(2) skin allergy test: present composition floral water to human body skin substantially without sensitization.
8, curative effect explanation
More than test result indicate that, the traditional Chinese medicine composition for treating group total effective rate that the present invention provides is 95%, hence it is evident that be better than
Matched group, has rapid-action, the advantages such as relieving itching and eliminating swelling is effective.
Model case
1, certain is permitted, female, 6 years old.Before not using this product, after mosquito bite, the place of biting there will be redness, bulge, pruritus
Etc. symptom, pruritus is hard to bear, is unable to bear scratching and grabs, and red and swollen bulge just can gradually be disappeared after two days.Within 10 minutes after mosquito bite, make
The liniment prepared by the embodiment of the present invention 1, pruritus disappeared after 4 minutes, and red and swollen, bulge was disappeared after 10 minutes.Carry with,
It is used for multiple times, antipruritic evident in efficacy with detumescence.
2, Xue, man, 50 years old.Before not using this product, after mosquito bite, the place of biting there will be redness, bulge, pruritus
Etc. symptom, red and swollen area is relatively big, just can gradually disappear after 3 days.Within 30 minutes after mosquito bite, the embodiment of the present invention 2 is used to prepare
The ointment obtained, pruritus disappeared after 5 minutes, and red and swollen, bulge was disappeared after 20 minutes.By being used for multiple times, detumescence and antipruritic treatment
Effect is notable.
3, Lee, man, 10 years old.Before not using this product, after mosquito bite, the place of biting there will be redness, bulge, pruritus
Etc. symptom, red and swollen area is relatively big, just can gradually disappear after 3 days.Within 20 minutes after mosquito bite, the embodiment of the present invention 5 is used to prepare
The spray obtained, pruritus disappeared after 4 minutes, and red and swollen, bulge was disappeared after 20 minutes.By being used for multiple times, detumescence and antipruritic treatment
Effect is notable.
The above is only the preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
For Yuan, under the premise without departing from the principles of the invention, it is also possible to make some improvements and modifications, these improvements and modifications also should
It is considered as protection scope of the present invention.
Claims (12)
1. the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite, it is characterised in that it is former by following parts by weight
Material medicine prepares:
The Radix Astragali 30～80 parts, Calculus Bovis 1～10 parts, Herba Scutellariae Barbatae 20～60 parts, Radix Glycyrrhizae 30～60 parts, the Fructus Kochiae 30～70 parts, Radix Sophorae Flavescentis
20～60 parts, Cortex Cinnamomi 30～60 parts, Flos Caryophylli 20～60 parts, wherein Calculus Bovis can replace with artificial Calculus Bovis or In vitro cultured Calculus Bovis.
The Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite the most according to claim 1, it is characterised in that it by under
The crude drug of row parts by weight prepares:
The Radix Astragali 50 parts, Calculus Bovis 6 parts, Herba Scutellariae Barbatae 40 parts, 50 parts of Radix Glycyrrhizae, the Fructus Kochiae 50 parts, Radix Sophorae Flavescentis 40 parts, Cortex Cinnamomi 50 parts, Flos Caryophylli 50
Part.
The Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite the most according to claim 1, it is characterised in that it by under
The crude drug of row parts by weight prepares:
The Radix Astragali 30 parts, Calculus Bovis 1 part, Herba Scutellariae Barbatae 20 parts, 30 parts of Radix Glycyrrhizae, the Fructus Kochiae 30 parts, Radix Sophorae Flavescentis 20 parts, Cortex Cinnamomi 30 parts, Flos Caryophylli 20
Part.
The Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite the most according to claim 1, it is characterised in that it by under
The crude drug of row parts by weight prepares:
The Radix Astragali 80 parts, Calculus Bovis 10 parts, Herba Scutellariae Barbatae 60 parts, 60 parts of Radix Glycyrrhizae, the Fructus Kochiae 70 parts, Radix Sophorae Flavescentis 60 parts, Cortex Cinnamomi 60 parts, Flos Caryophylli 60
Part.
5. the preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite described in Claims 1 to 4, its feature exists
In, it comprises the following steps:
A: take the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae by weight, is broken into coarse powder by the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste Chinese medicine powder, adds
Ethanol, heating and refluxing extraction, filter, united extraction liquid, filtrate concentrates, and obtains medicinal liquid A；
B: take the Fructus Kochiae and Radix Sophorae Flavescentis by weight, by the Fructus Kochiae and Radix Sophorae Flavescentis boiling, filters, and united extraction liquid, by filtrate
Concentrating under reduced pressure, is cooled to room temperature, adds ethanol, and limit edged stirs, and makes fully to mix, and stands, filters precipitate, filtrate is reclaimed
Ethanol is also concentrated into extractum, adds ethanol, and heating makes extractum dissolve, and the solution left standstill after dissolving filters precipitate, obtains medicine
Liquid B；
C: upper macroporous adsorptive resins after the medical liquid B mixing that medicinal liquid A step A obtained and step B obtain, after standing adsorption,
Being washed with deionized water that to take off to eluent be colourless, discard eluent, it is light for being then eluted to eluent with low concentration C1～3 alcohol
Color, discards eluent, then with high concentration C1～3 alcohol eluting, collects eluent, and eluent recovered under reduced pressure removes C1～3 alcohol, dense
Contracting, obtains medicinal liquid C；
D: take Cortex Cinnamomi and Flos Caryophylli by weight, uses extraction by steam distillation, obtains extractive of volatile oil；
E: the extractive of volatile oil mixing that medicinal liquid C step C obtained and step D obtain, adds Calculus Bovis by weight, mixed
Even, to obtain final product.
The preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite the most according to claim 5, its feature
Being, it comprises the following steps:
Step A: take the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae by weight, is ground into coarse powder by the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste, adds
Such as volumetric concentration 30%～80% ethanol, heating and refluxing extraction 1～3 times, each ethanol volumetric usage be medical material weight 4～
10 times amount, each 1～3 hour, filter and merge 1～3 extracting solution, being concentrated into 0.25～5g crude drug/mL medicinal liquid A；
Step B: take the Fructus Kochiae and Radix Sophorae Flavescentis by weight, by the Fructus Kochiae and Radix Sophorae Flavescentis boiling 1～3 times, adds water volume every time
Amount is 2～10 times of medical material weight, each 1～3 hour, filters and merges 1～3 extracting solution, concentrate filtrate to former
The 1/3～1/2 of volume, is cooled to room temperature, adds the 60%-95% ethanol of 1～3 times of volume, and limit edged stirs, and makes the most mixed
Even, stand 12～36 hours, filter precipitate, by filtrate recycling ethanol and to be concentrated into 50 DEG C of relative densities be 1.20～1.40
Thick shape extractum, adds 20%～60% ethanol, and heating makes extractum dissolve, the solution left standstill 12 after dissolving～36 hours, filter
Except precipitate, obtain medical liquid B；
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water and takes off to washing
De-liquid is colourless, discards eluent, be then 5 by concentration～the C1 of 30%～3 alcohol to be eluted to eluent be light color, discard eluting
Liquid, then with the C1 that concentration is 40%～95%～3 alcohol eluting, collect eluent, eluent reduces pressure, and reclaims and removes C1～3 alcohol, dense
It is reduced to 0.5～3g crude drug/mL medicinal liquid C；
Step D: take Cortex Cinnamomi, Flos Caryophylli by weight, adds medical material weight 8～the water of 15 times of volumes, uses vapor distillation
Method is extracted, and obtains extractive of volatile oil；
Step E: the extractive of volatile oil mixing that medicinal liquid C step C obtained and step D obtain, adds Calculus Bovis by weight,
Mixing, to obtain final product.
The preparation method of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite the most according to claim 5, its feature
It is: it comprises the following steps:
Step A: take the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae by weight, is ground into coarse powder by the Radix Astragali, Radix Glycyrrhizae and Herba Scutellariae Barbatae three taste, adds
Entering 8 times amount volumetric concentrations is 50% ethanol, heating and refluxing extraction 3 times, each 2 hours, filters and merge 3 extracting solution, concentrates
To 2g crude drug/mL medicinal liquid A, standby；
Step B: take the Fructus Kochiae and Radix Sophorae Flavescentis by weight, by the Fructus Kochiae and Radix Sophorae Flavescentis boiling 3 times, the volume that every time adds water is
10 times of medical material weight, each 1.5 hours, filter and merge 3 extracting solution, concentrate filtrate to original volume 1/3～
1/4, it is cooled to room temperature, adds 95% ethanol of 3 times of volumes, limit edged stirs, and makes fully to mix, stands 24 hours, and it is heavy to filter
Shallow lake thing, by filtrate recycling ethanol and be concentrated into the thick shape extractum that 55 DEG C of relative densities are 1.30～1.35, adds volumetric concentration
50% ethanol, heating makes extractum dissolve, the solution left standstill after dissolving 24 hours, filters precipitate, obtains medical liquid B；
Step C: upper macroporous adsorptive resins after medicinal liquid A and medical liquid B being mixed, after standing adsorption, is washed with deionized water and takes off to washing
De-liquid is colourless, discards eluent, is then light color with the ethanol elution that volumetric concentration is 20% to eluent, discards eluting
Liquid, then be the ethanol elution of 50% by volumetric concentration, collect eluent, eluent reduces pressure, and reclaims and removes ethanol, is concentrated into 3g raw
Medicine/mL medicinal liquid C；
Step D: take Cortex Cinnamomi, Flos Caryophylli, adds the water of 10 times of volumes of medical material weight, uses extraction by steam distillation, is waved
Hair oil extract；
Step E: extractive of volatile oil mixing medicinal liquid C and step D obtained, adds Calculus Bovis, mixing, to obtain final product.
8. according to the preparation side of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite described in any one of claim 5 to 7
Method, it is characterised in that: C1～3 alcohol described in step C are methanol, ethanol or propanol.
9. according to the preparation side of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite described in any one of claim 5 to 7
Method, it is characterised in that described macroporous adsorbent resin is D101, HPD100, AB-8 or X-5 macroporous adsorbent resin.
10. according to the preparation side of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite described in any one of claim 5 to 7
Method, it is characterised in that the Chinese medicine extract of gained adds pharmaceutically acceptable carrier, prepares Chinese medicine preparation.
11. preparation methoies of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite according to claim 10, it is special
Levying and be, described Chinese medicine preparation is the external preparation of liniment, ointment, gel, spray or aerosol.
12. according to the preparation side of the Chinese medicine composition of relieving itching and eliminating swelling after mosquito bite described in any one of claim 5 to 7
Method, it is characterised in that the Chinese medicine extract of gained adds essence, is prepared as floral water with second alcohol and water furnishing finite concentration.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
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Cited By (5)
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| CN106859962A (en) * | 2017-01-23 | 2017-06-20 | 安徽绿莹彩龙艾绒制药有限公司 | A kind of medicine moxa-moxibustion of moxibustion bite by mosquitos |
| CN109125163A (en) * | 2017-08-25 | 2019-01-04 | 伽蓝（集团）股份有限公司 | Glacial water composite extract of rough gentian, emblic and Flos meconopsis quintuplinerviae and its preparation method and application |
| CN111588672A (en) * | 2020-06-30 | 2020-08-28 | 河北农业大学 | Edible itching-relieving emulsion for mosquito bites and preparation method thereof |
| CN111658714A (en) * | 2020-06-04 | 2020-09-15 | 青岛瑞思德生物科技有限公司 | Traditional Chinese medicine composition for relieving itching and diminishing swelling after mosquito bites |
| CN114917161A (en) * | 2022-06-07 | 2022-08-19 | 栾云鹏 | Composition for relieving itching and pain after mosquito bites and preparation method and application thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109125163B (en) * | 2017-08-25 | 2022-07-22 | 伽蓝（集团）股份有限公司 | Glacier water composite extract of gentian, emblic leafflower fruit and artemisia integrifolia as well as preparation method and application thereof |
| CN111658714A (en) * | 2020-06-04 | 2020-09-15 | 青岛瑞思德生物科技有限公司 | Traditional Chinese medicine composition for relieving itching and diminishing swelling after mosquito bites |
| CN111588672A (en) * | 2020-06-30 | 2020-08-28 | 河北农业大学 | Edible itching-relieving emulsion for mosquito bites and preparation method thereof |
| CN114917161A (en) * | 2022-06-07 | 2022-08-19 | 栾云鹏 | Composition for relieving itching and pain after mosquito bites and preparation method and application thereof |
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| CN106138241B (en) | 2018-11-20 |
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Address after: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Applicant after: LEIYUNSHANG PHARMACEUTICAL GROUP Co.,Ltd. Address before: 215009 Suzhou high tech Zone, Jiangsu, No. 86 Applicant before: Lei Yun Shang Pharmaceutical Co.,Ltd. |
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Denomination of invention: A traditional Chinese medicine composition for relieving itching and detumescence after mosquito bites and its preparation method Effective date of registration: 20221019 Granted publication date: 20181120 Pledgee: Shanghai Bank Co.,Ltd. Suzhou Branch Pledgor: LEIYUNSHANG PHARMACEUTICAL GROUP Co.,Ltd. Registration number: Y2022320010593 |
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