CN114984075B

CN114984075B - Preparation method of Hexi chrysanthemum extract, preparation and use thereof

Info

Publication number: CN114984075B
Application number: CN202210581851.4A
Authority: CN
Inventors: 季志红; 陈金成; 马璇; 李柯翱; 杨青青; 刘婷
Original assignee: Xinjiang Qimu Pharmaceutical Research Institute Co ltd
Current assignee: Xinjiang Qimu Pharmaceutical Research Institute Co ltd
Priority date: 2022-05-26
Filing date: 2022-05-26
Publication date: 2023-09-26
Anticipated expiration: 2042-05-26
Also published as: CN114984075A

Abstract

The invention relates to a preparation method of a feverfew extract, a preparation and application thereof. The preparation method of the Hexi chrysanthemum extract comprises the following steps: adding extraction solvent into the Hexi chrysanthemum, extracting by adopting a reflux method, an immersion method or a percolation method, and filtering to obtain an extracting solution, namely the Hexi chrysanthemum extract. The invention also discloses a preparation and application of the feverfew extract. The preparation method of the Hexi chrysanthemum extract, the preparation and the application thereof have simple and reasonable extraction process, can obtain effective components, effectively treat psoriasis and pityriasis rosea, and are applied to the preparation of the medicines for treating psoriasis and pityriasis rosea.

Description

Preparation method of Hexi chrysanthemum extract, preparation and use thereof

Technical Field

The invention belongs to the technical field of medicine application, and particularly relates to a preparation method of a feverfew extract, a preparation and application thereof.

Background

Psoriasis is a common chronic and easy-to-relapse skin disease, and the clinical manifestation of the psoriasis is chronic and non-infectious skin damage with different severity, and the serious psoriasis patients can involve 20-80% of whole body skin, and the affected skin has a wide range. Certain limited psoriasis (such as involving only palmoplantar skin) are also a serious type of disorder by causing dysfunction. Psoriasis can cause physiological and psychological damage to patients regardless of the extent of skin damage. The primary purpose of psoriasis treatment is to remove skin damage within a certain period of time, and especially for severe psoriasis patients, the treatment purpose is to relieve clinical symptoms of the psoriasis patients, such as skin inflammation, red swelling, peeling, itching, pain and the like, prevent recurrence and gradually achieve the purpose of healing.

Pityriasis rosea is an inflammatory skin disease of unknown etiology with a incidence of about 0.1% and typical symptoms are pityriasis rosea covered with chaff-like scales, maculopapules. There may be a certain difference in clinical manifestations at different times of skin lesions. Some patients have subjective symptoms such as itching, and some patients can have certain precursor symptoms before onset, such as general discomfort, low fever, and the like, and are well developed on the proximal ends of the trunk and limbs.

The traditional Chinese medicine replaces most clinical chemical medicines, particularly antibiotics, with the unique advantages, can reduce the risk of abuse of antibiotics, is beneficial to improving the medical quality and reduces the hospitalizing cost of patients. Therefore, the discovery and development of the traditional Chinese medicine and the natural medicine has important significance for preventing and treating skin diseases such as atopic dermatitis, psoriasis, pityriasis rosea and the like.

Hexi chrysanthemum, also Hovenia dulcis, hexi Sonchus arvensis, artemisia equi, is the dried stem, branch, bark and root of Hexi chrysanthemum of Compositae. The method is used in the environments of sand, sand edges, sand hills, low ground, gobi gullies and sand fields, and the altitudes are-42-1800 m. Distributed Gansu (Lanzhou, anxi, spring, jinta), xinjiang (Notoptera, uqia, yecheng, in the field, shufu, ackesu, turpan, wheel platform, tokeson, plough). However, to date, there has not been a process for preparing a medicinal extract from feverfew nor the pharmaceutical use of feverfew extract.

Based on the above, the invention provides the extraction method and the application of the feverfew, in particular the application in preparing the medicine for treating psoriasis, and the feverfew is taken as the raw medicinal material, which is favorable for sustainable and rational development and utilization and resource protection, and has obvious advantages.

Disclosure of Invention

The invention aims to provide a preparation method of a feverfew extract, which can effectively extract medicinal components in feverfew.

In order to achieve the above purpose, the technical scheme adopted is as follows:

the preparation method of the Hexi chrysanthemum extract comprises the following steps: adding extraction solvent into the Hexi chrysanthemum, extracting by adopting a reflux method, or an immersion method, or a percolation method, and filtering to obtain an extracting solution, namely the Hexi chrysanthemum extract.

Further, the extraction solvent is water, ethanol or lipophilic solvent;

the lipophilic solvent is at least one of ethyl acetate and petroleum ether.

Still further, the preparation method further comprises: concentrating under reduced pressure and/or removing impurities.

Still further, the temperature of the reduced pressure concentration is 40-85 ℃, and the reduced pressure concentration is carried out until the relative density is 1.05-1.30;

the impurity removal method comprises the following steps: alcohol precipitation, water precipitation, organic solvent extraction, or macroporous resin chromatography;

the organic solvent is chloroform, ethyl acetate and n-butanol.

Still further, when the extraction solvent is water, the mass volume ratio of the extraction solvent to the feverfew is 1: 3-20 g/ml, wherein the extraction times are 1-5 times, and the impurity is removed by adopting alcohol precipitation, or organic solvent extraction, or macroporous resin chromatography;

when the extraction solvent is 30-95% ethanol, the mass volume ratio of the extraction solvent to the feverfew is 1: 3-15 g/ml, wherein the extraction times are 1-5 times, and water sedimentation, or organic solvent extraction, or macroporous resin chromatography is adopted to remove impurities;

when the extraction solvent is 50-95% lipophilic solvent, the mass volume ratio of the extraction solvent to the Hexi chrysanthemum is 1: 5-15 g/ml, extracting for 1-5 times, removing impurities by alcohol precipitation, or ethyl acetate/n-butanol extraction, or macroporous resin chromatography

It is another object of the present invention to provide formulations of the feverfew extract that allow for better use of the feverfew extract.

The preparation of the Hexi chrysanthemum extract comprises the Hexi chrysanthemum extract obtained by the preparation method and pharmaceutically acceptable auxiliary materials;

the auxiliary materials are at least one of gel framework materials, humectant, preservative, permeation promoter, antioxidant, emulsifier, surfactant, propellant, thickener, ethanol and purified water;

the preparation is one of powder, liniment, gel, lotion, ointment, aerosol and spray.

Further, the preparation is in the form of liniment and ointment;

the preparation method of the preparation of the feverfew extract of the liniment and the ointment comprises the following steps:

adding water into the Hexi chrysanthemum, extracting by adopting a reflux method, filtering, extracting for 2 times, and combining the filtrates to obtain an extracting solution;

(1) Concentrating the extracting solution at 40-85 ℃ under reduced pressure until the relative density is 1.05-1.30, thus obtaining a preparation of the linimentum type feverfew extract;

(2) Uniformly mixing potassium sorbate, glycerol, triethanolamine, sodium sulfite and the extracting solution under the condition of water bath heating to obtain solution A;

glyceryl stearate, glyceryl monostearate and white vaseline, and laurocapramUniformly mixing ketone under the condition of heating in a water bath to obtain a solution B;

stirring the solution A and the solution B at 50-60 ℃ for 15-25 min, cooling to 25-30 ℃ and stirring for 15-25 min to obtain a preparation of the ointment-type feverfew extract;

the mass ratio of the extracting solution to the glycerol to the triethanolamine to the sodium sulfite to the glyceryl stearate to the glyceryl monostearate to the white vaseline is 1.5-2:1.8-2.2: 0.9-1.1:0.28-0.32:1.8-2.2:1.8-2.2:0.9-1.1.

Still further, in the reflux extraction, the mass ratio of the feverfew to the water is 1:8, and the feverfew and the water are heated and refluxed for 1.5 hours at 100 ℃;

the extracting solution, glycerol, triethanolamine, sodium sulfite, glyceryl stearate and monostearinGlyceride, white vaseline and laurocapramThe mass ratio of ketones was 1.7:2:1:0.3:2:2:1:0.1.

The invention also aims to provide the application of the Hexi chrysanthemum extract, develop the medicinal effect of the Hexi chrysanthemum extract in medicaments for treating psoriasis and pityriasis rosea, and provide a new idea for treating psoriasis and pityriasis rosea.

Further, the psoriasis is psoriasis vulgaris, psoriasis pustulosa, psoriasis arthropatica and psoriasis erythrodermically.

Compared with the prior art, the invention has the beneficial effects that:

1. clinical experiments prove that the plant extract has remarkable effect on treating psoriasis and pityriasis rosea, so that the plant extract can effectively treat psoriasis and pityriasis rosea and is applied to preparation of medicaments for psoriasis and pityriasis rosea.

Can effectively treat psoriasis and pityriasis rosea and can be applied to the preparation of medicaments for treating psoriasis and pityriasis rosea.

2. The plant extract and the medicine for treating psoriasis and pityriasis rosea prepared by the plant extract can be prepared into pharmaceutically acceptable preparations, and different dosage forms can be conveniently adopted according to different administration objects.

3. The extraction process is simple and reasonable, the effective components can be obtained, and the extract has definite efficacy. The invention provides a method for the development of non-medicinal plants, and provides a new way for the reasonable utilization of resources while treating diseases.

Detailed Description

In order to further illustrate the preparation method of the Hexi chrysanthemum extract and the preparation and application thereof, which are disclosed by the invention, the expected aim of the invention is achieved, and the preparation method of the Hexi chrysanthemum extract and the preparation and application thereof, which are disclosed by the invention, are combined with the preferred embodiments, and the specific implementation, structure, characteristics and efficacy thereof are described in detail below. In the following description, different "an embodiment" or "an embodiment" do not necessarily refer to the same embodiment. Furthermore, the particular features, structures, or characteristics of one or more embodiments may be combined in any suitable manner.

The preparation method of the Hexi chrysanthemum extract, the preparation and the application thereof are described in further detail below by combining specific examples:

the technical scheme of the invention is as follows:

Preferably, the extraction solvent is water, ethanol or lipophilic solvent;

the lipophilic solvent is at least one of ethyl acetate and petroleum ether, and is not limited thereto.

Further preferably, the preparation method further comprises: concentrating under reduced pressure and/or removing impurities.

Further preferably, the temperature of the reduced pressure concentration is 40-85 ℃, and the reduced pressure concentration is carried out until the relative density is 1.05-1.30;

the organic solvent is chloroform, ethyl acetate, n-butanol or other organic solvents.

Further preferably, when the extraction solvent is water, the mass volume ratio of the extraction solvent to the feverfew is 1: 3-20 g/ml, wherein the extraction times are 1-5 times, and the impurity is removed by adopting alcohol precipitation, or organic solvent extraction, or macroporous resin chromatography;

when the extraction solvent is 50-95% lipophilic solvent, the mass volume ratio of the extraction solvent to the Hexi chrysanthemum is 1: 5-15 g/ml, wherein the extraction times are 1-5 times, and the impurity is removed by adopting alcohol precipitation, or ethyl acetate/n-butyl alcohol extraction, or macroporous resin chromatography.

The percentage of the extraction solvent is volume percentage.

Preferably, the preparation is in the form of liniment or ointment;

the extracting solution, glycerol, triethanolamine, sodium sulfite, glyceryl stearate and monostearinThe mass ratio of the glyceride to the white vaseline is 1.5-2:1.8-2.2: 0.9-1.1:0.28-0.32:1.8-2.2:1.8-2.2:0.9-1.1. The addition amount of potassium sorbate is 0.01 to 0.3 weight percent of the ointment, and the laurel nitrogen is addedThe addition amount of ketone is 0-2 wt% of the ointment.

Further preferably, in the reflux extraction, the mass ratio of the feverfew to the water is 1:8, and the feverfew and the water are heated and refluxed for 1.5 hours at 100 ℃;

preferably, the extract, glycerol, triethanolamine, sodium sulfite, glyceryl stearate, glyceryl monostearate, white vaseline, and laurocapramThe mass ratio of ketones was 1.7:2:1:0.3:2:2:1:0.1.

The application of the Hexi chrysanthemum extract provides a new idea for developing the medicinal effect of the Hexi chrysanthemum extract and also for treating psoriasis and pityriasis rosea.

Preferably, the psoriasis is psoriasis vulgaris, psoriasis pustulosa, psoriasis arthropatica, and psoriasis erythrodermically.

Preparation of the Hexi chrysanthemum extract:

the feverfew in the examples is the dried root, stem, leaf of feverfew plant.

(1) Water is used as an extraction solvent:

example 1.

Extracting flos Chrysanthemi with 8 times of water, extracting the residue with 4 times of water, mixing the water extractive solutions, and concentrating under reduced pressure at 40deg.C to relative density of 1.05 to obtain flos Chrysanthemi extract.

Example 2.

Taking the feverfew, adding water with the mass of 20 times of the feverfew, extracting by adopting an immersion method, and filtering to obtain water extract;

concentrating the water extractive solution at 85deg.C under reduced pressure to relative density of 1.30, and removing impurities by alcohol precipitation to obtain Hexi chrysanthemum extract.

Example 3.

Extracting Hexi chrysanthemum with water 5 times of the mass of the Hexi chrysanthemum, extracting the residues by adopting an immersion method, filtering the residues after 4 times of water extraction, and combining water extracts;

concentrating the water extract under reduced pressure at 65deg.C to relative density of 1.15, extracting with organic solvent (chloroform), and recovering organic solvent to obtain Hexi chrysanthemum extract.

Example 4.

Extracting Hexi chrysanthemum with 3 times of water by percolation, extracting the residue with water for 4 times, and mixing the water extracts;

concentrating the water extract under reduced pressure at 60deg.C to relative density of 1.10, extracting with organic solvent (isopropanol), and recovering organic solvent to obtain Hexi chrysanthemum extract.

Example 5.

Extracting flos Chrysanthemi with 3 times of water by reflux method for 2 times, mixing filtrates, filtering, precipitating with 50% ethanol, and removing impurities to obtain flos Chrysanthemi extract.

Example 6.

Adding 15 times of water into the feverfew, extracting for 5 times by percolation, mixing filtrates, and filtering to obtain water extract;

removing impurities from the water extract by macroporous resin column chromatography, eluting with ethanol to obtain eluate with volume fraction change of 0-100%, and collecting eluate of 30-95% ethanol to obtain the feverfew extract.

Example 7.

Extracting Hexi chrysanthemum with 9 times of water for 3 times by reflux method, mixing filtrates, and filtering to obtain water extractive solution;

extracting the water extract with organic solvent (ethyl acetate) to remove impurities, collecting the extract, and recovering the organic solvent to obtain the Hexi chrysanthemum extract.

(2) Ethanol is used as an extraction solvent:

example 8.

Extracting with 85% ethanol (mass volume ratio of Hexi chrysanthemum to 85% ethanol is 1:10 g/ml), filtering, concentrating the filtrate under reduced pressure at 65deg.C to relative density of 1.10, and removing impurities by water precipitation to obtain Hexi chrysanthemum extract.

Example 9.

Extracting flos Chrysanthemi with 8 times of 75% ethanol by percolation, filtering, mixing extractive solutions, concentrating under reduced pressure at 60deg.C to relative density of 1.05, and removing impurities by macroporous resin column chromatography to obtain flos Chrysanthemi extract.

Example 10.

Taking the feverfew, adding 85% ethanol (the mass volume ratio of the feverfew to the 85% ethanol is 1:5 g/ml), and extracting for 1 time by adopting an immersion method; then adding 85% ethanol 10 times of the total amount, extracting for 2 times by soaking method, and mixing the 3 times of soaking and filtering extractive solutions.

Concentrating under reduced pressure at 40deg.C until the relative density is 1.05, and removing impurities by water precipitation to obtain the feverfew extract.

Example 11.

Taking the feverfew, adding 55% ethanol (the mass volume ratio of the feverfew to the 55% ethanol is 1:8 g/ml), and extracting for 1 time by adopting an immersion method; then adding 45% ethanol with the dosage of 12 times, extracting for 3 times by adopting an immersion method, and combining the extracting solutions after 4 times of immersion filtration.

Concentrating the extractive solution at 40deg.C under reduced pressure to relative density of 1.05, extracting with organic solvent (n-butanol) to remove impurities, and recovering organic solvent to obtain Hexi chrysanthemum extract.

Example 12.

Taking the feverfew, adding 60% ethanol (the mass volume ratio of the feverfew to the 60% ethanol is 1:8 g/ml), and extracting for 1 time by a percolation method; adding 40% ethanol 12 times of the total amount, percolating for 3 times, filtering, and mixing the extractive solutions.

Concentrating the extractive solution at 45deg.C under reduced pressure to relative density of 1.07, extracting with n-butanol to remove impurities, and recovering organic solvent to obtain Hexi chrysanthemum extract.

Example 13.

Extracting with 95% ethanol (mass volume ratio of Hexi chrysanthemum to 95% ethanol is 1:3 g/ml) for 5 times by reflux method, mixing filtrates, filtering, and removing impurities by water precipitation to obtain Hexi chrysanthemum extract

Example 14.

Taking the feverfew, adding 50% ethanol (the mass volume ratio of the feverfew to the 50% ethanol is 1:15 g/ml), extracting for 3 times by a reflux method, merging filtrate, filtering, removing impurities by macroporous resin column chromatography, taking the ethanol as eluent, changing the volume fraction to 0-100%, and collecting eluent of 30-95% ethanol to obtain the feverfew extract.

Example 15.

Extracting with 70% ethanol 9 times of the above materials for 2 times, mixing filtrates, filtering, extracting with organic solvent (ethyl acetate), and removing impurities to obtain Hexi Sinensifolium extract.

Example 16.

Extracting with 60% ethanol (mass volume ratio of Hexi chrysanthemum to 60% ethanol is 1:6 g/ml) for 4 times, mixing filtrates, filtering, extracting with organic solvent (isopropanol), and removing impurities to obtain Hexi chrysanthemum extract.

Example 17.

Extracting with 80% ethanol (mass volume ratio of Hexi chrysanthemum to 80% ethanol is 1:12 g/ml) for 3 times by reflux method, mixing filtrates, filtering, and removing impurities by water precipitation to obtain Hexi chrysanthemum extract.

(3) Lipophilic solvents were used as extraction vehicles:

example 18.

Adding 95% n-butanol (mass volume ratio of Hexi chrysanthemum to 95% n-butanol is 1:15 g/ml), percolating, filtering, and removing impurities by water precipitation to obtain Hexi chrysanthemum extract.

Example 19.

Taking the feverfew, adding 50% ethyl acetate (the mass volume ratio of the feverfew to the extraction solvent is 1:10 g/ml), extracting for 2 times by a percolation method, combining the filtrates, filtering, and combining the extracts; removing impurities by macroporous resin chromatography, taking ethanol as eluent, changing the volume fraction to 0-100%, and collecting 30-95% ethanol eluent to obtain the feverfew extract.

Example 20.

Adding 60% chloroform (the mass volume ratio of the Hexi chrysanthemum to the extraction solvent is 1:8 g/ml), and extracting for 1 time by adopting an immersion method; adding 50% isopropanol 8 times of the total amount, extracting for 3 times by soaking method, filtering, and mixing the extractive solutions.

Removing impurities from the extractive solution by water precipitation to obtain the Hexi chrysanthemum extract.

Example 21.

Taking the feverfew, adding 50% amyl alcohol (the mass volume ratio of the feverfew to the extracting solvent is 1:7 g/ml), extracting for 5 times by adopting an immersion method, combining the extracting solutions, and filtering; removing impurities by macroporous resin chromatography, eluting with ethanol to obtain eluate with volume fraction change of 0-100%, and collecting eluate of 30-95% ethanol to obtain Hexi chrysanthemum extract.

Example 22.

Extracting Hexi chrysanthemum with 95% ethyl acetate (the mass-volume ratio of Hexi chrysanthemum to the extracting solvent is 1:5 g/ml) for 1 time by reflux method, filtering, and removing impurities by water precipitation method to obtain Hexi chrysanthemum extract.

Example 23.

Taking the feverfew, adding 50% ethyl acetate (the mass volume ratio of the feverfew to the extraction solvent is 1:15 g/ml), extracting for 5 times by adopting an immersion method, combining the filtrates, and filtering; removing impurities by macroporous resin chromatography, eluting with ethanol to obtain eluate with volume fraction change of 0-100%, and collecting eluate of 30-95% ethanol to obtain Hexi chrysanthemum extract.

Example 24.

Taking the feverfew, adding 70% amyl alcohol (the mass volume ratio of the feverfew to the extracting solvent is 1:9 g/ml), extracting for 2 times by adopting a reflux method, combining the filtrates, filtering, and filtering; removing impurities by macroporous resin chromatography, eluting with ethanol to obtain eluate with volume fraction change of 0-100%, and collecting eluate of 30-95% ethanol to obtain Hexi chrysanthemum extract.

Example 25.

Taking the feverfew, adding 80% petroleum ether (the mass volume ratio of the feverfew to the extraction solvent is 1:12 g/ml), extracting for 4 times by adopting a reflux method, combining the filtrates, and extracting with an organic solvent (n-butanol) to remove impurities to obtain the feverfew extract.

(II) preparation of Hexi chrysanthemum extract:

example 26.

Adding 5000g of purified water into 500g of feverfew, heating and refluxing at 100 ℃ for 1.5 hours, and filtering to obtain feverfew extract;

adding 20g of borneol and 2g of potassium sorbate into the feverfew extract, and uniformly stirring to obtain the feverfew medicine.

Filling the feverfew medicine and the propellant into an aerosol bottle, and preparing the feverfew medicine in aerosol form; filling the feverfew medicine into a spray bottle to obtain the feverfew medicine in a spray form.

The prepared feverfew medicine can be prepared into aerosol type and spray type feverfew medicines, the medicines can directly reach an action part or an absorption part, the effect is quick, the medicines are packaged in a closed container, the cleanness and the sterile state can be kept, and the pollution possibility of the medicines is reduced. In addition, the container is opaque and is protected from light, and is not in direct contact with oxygen and moisture in the air, so that the stability of the medicine is improved.

Example 27.

(1) Weighing 500g of synthetic feverfew, adding 5L of water, heating and refluxing for 1.5h at 100 ℃, extracting for 2 times, standing and cooling, filtering by adopting 200-300 meshes, and adding a proper amount of potassium sorbate into filtrate to obtain feverfew plant extract.

(2) Weighing 20g of glycerin, 10g of triethanolamine, 3g of sodium sulfite and 17g of a feverfew plant extract, and heating in a water bath at 80 ℃ to stir and dissolve to obtain a solution A;

weighing 20g of glyceryl stearate, 20g of glyceryl monostearate and glyceryl distearate, 10g of white vaseline and laurel nitrogen1g of ketone, heating in 80 ℃ water bath, stirring and dissolving to obtain solution B;

(3) Stirring the prepared solution A into the solution B, heating and stirring for 20min at 50-60 ℃, cooling to 25-30 ℃, and stirring for 20 min.

The feverfew medicine prepared by the embodiment is ointment, and the medicine can directly reach the action part or the absorption part, so that the effect is high.

Example 28.

Adding 5L of clear water into 500g of feverfew, heating and refluxing at 100 ℃ for 1.5 hours, and filtering to obtain feverfew extract;

preparing a dry extract from the feverfew extract, and then crushing the dry extract into fine powder to obtain extract powder;

mixing the extract powder, 50g of glycerol and 1g of ethylparaben, stirring uniformly, and concocting into paste to obtain paste form of Hexi chrysanthemum medicine.

The feverfew medicine prepared in the embodiment is paste, and the medicine is applied on the skin and kept for a long time, so that the medicine has quick effect.

Example 29.

drying the Hexi chrysanthemum extract to obtain dry Hexi chrysanthemum extract powder; mixing the dried powder of the Hexi chrysanthemum extract with 50g of starch, and making into powder to obtain the Hexi chrysanthemum medicine.

The feverfew medicine prepared in the embodiment is powder and can be externally used.

Example 30.

Adding 5L of clear water into 500g of feverfew, heating and refluxing at 100 ℃ for 2 hours, and filtering to obtain feverfew extract;

the preparation method comprises the steps of preparing a gel from the feverfew extract, 300g of xanthan gum, 6g of mint essence and 2g of sodium benzoate, and obtaining the feverfew medicine.

The feverfew medicine prepared in the embodiment is gel, and is administrated through skin, so that the medicine has a quick effect.

Example 31.

preparing the Hexi chrysanthemum extract and 0.5g sodium benzoate into lotion to obtain Hexi chrysanthemum medicine.

The feverfew medicine prepared in the embodiment is lotion and is administrated through skin, so that the medicine takes effect quickly; the feverfew medicine disclosed by the embodiment of the invention contains feverfew, is simple in components and small in toxic and side effects, can be used for effectively treating psoriasis and pityriasis rosea, and can be used for preparing medicines for treating psoriasis and pityriasis rosea.

Example 32.

concentrating the Hexi chrysanthemum extract under reduced pressure at 40-85 ℃ until the relative density is 1.05-1.30, and preparing the Hexi chrysanthemum extract into liniment with 4g of mint essence and 2g of sodium benzoate.

The feverfew medicine prepared in the embodiment is a liniment and is administrated through the skin, so that the effect is quick; the feverfew medicine disclosed by the embodiment of the invention contains feverfew, is simple in components and small in toxic and side effects, can be used for effectively treating psoriasis and pityriasis rosea, and can be used for preparing medicines for treating psoriasis and pityriasis rosea.

Example 33.

preparing a feverfew extract into a dry extract and crushing the dry extract into fine powder to obtain extract powder; mixing the extract powder, 50g of glycerol and 1g of ethylparaben, stirring uniformly, and concocting into paste to obtain paste medicine; a unit dose of pasty medicine is smeared on medical non-woven fabrics, and the medicine is prepared by heating and drying, covering a protective layer and preparing the plaster-type feverfew medicine.

The feverfew medicine prepared in the embodiment is a patch, and is administrated through skin, so that the medicine takes effect quickly; the feverfew medicine disclosed by the embodiment of the invention contains feverfew, is simple in components and small in toxic and side effects, can be used for effectively treating psoriasis and pityriasis rosea, and can be used for preparing medicines for treating psoriasis and pityriasis rosea.

Example 34.

drying the Hexi chrysanthemum extract into powder to obtain medicine powder; mixing the medicinal powder, 0.5g of ethylparaben and 50g of ethanol, adding 50ml of purified water, and making into coating type Hexiju medicine.

The feverfew medicine prepared in the embodiment is a liniment and is administrated through skin, so that the effect is quick; the feverfew medicine disclosed by the embodiment of the invention contains feverfew, is simple in components and small in toxic and side effects, can be used for effectively treating psoriasis and pityriasis rosea, and can be used for preparing medicines for treating psoriasis and pityriasis rosea.

Clinical experiments:

82 patients with psoriasis vulgaris confirmed by the department of dermatology outpatient department of a certain hospital from 6 months 2019 to 2 months 2022 are selected, and are randomly divided into 42 treatment groups and 40 control groups by adopting a random number table method. The sex data of the 2 groups of patients are compared, the difference has no statistical significance (P > 0.05), and the sex data of the 2 groups of patients are comparable.

Reference is made to the clinical guidelines: the diagnosis standard and stage and degree grading standard of psoriasis vulgaris in skin disease. Diagnosing according to skin damage manifestation, morphology and good hair positions: skin lesions appear as red papules, maculopapules or plaques, covered with silvery white scales; the skin damage is in the shape of drop, map, coin, ring, etc.; it is good for scalp, back and limbs.

Meets the diagnosis standard of psoriasis vulgaris and is in the middle-heavy patient age of 18-60 years in the running period and the stable period; voluntarily attending the study and signing informed consent.

The control group was treated with NB-UVB irradiation. The patient wears the protective glasses and the ultraviolet-proof mask to expose the skin damage part, and uses the phototherapy instrument to carry out irradiation treatment.

The treatment group adopts the feverfew medicine prepared in the example 32, and the affected part is scrubbed/rubbed for 3 to 5 times every day according to the severity of the illness.

TABLE 1

TABLE 2

60 cases of pityriasis rosea are confirmed in the department of dermatology and the ward of a certain hospital, and 30 cases of pityriasis rosea are randomly divided into 30 cases of treatment groups and 30 cases of control groups by adopting a random digital table method. Meets the diagnosis standard of pityriasis rosea in Chinese clinical dermatology and Chinese medical disease diagnosis curative effect standard. Diagnosis is performed based on the appearance, morphology, etc. of skin lesions. The control group was treated with NB-UVB irradiation.

The treatment group adopts the feverfew medicine prepared in the example 32, and the affected part is scrubbed for 3 to 5 times per day according to the severity of the illness.

TABLE 3 Table 3

TABLE 4 Table 4

From tables 2 and 4, it can be seen that the medicaments prepared from the feverfew extract can effectively treat psoriasis and pityriasis rosea.

Typical cases:

1. name: when a woman is in the middle of the year 58 years old.

Disease condition: leg bites at age 38 years old and gradually develops into a large number of ecdysis, pruritus and psoriasis vulgaris is diagnosed.

Dosage of the medicine: the feverfew drug prepared in example 32 was used, washed daily with water.

Condition after healing: after the patient uses the medicine for 2 weeks, the disease condition is improved, and after the medicine is continued for 2 months, the disease condition is basically cured.

2. Name: some women, now 36 years old, get the plums somehow.

Disease condition: when the hands are obviously desquamated, the scalp is desquamated, and the hands are also desquamated, and the hands are left in hospitals for half a month, so that a doctor diagnoses psoriasis (psoriasis is commonly called as psoriasis) and has no effect when taking medicines.

Dosage of the medicine: the whole body and the head of the Hexi chrysanthemum medicine prepared in the example 32 are washed by water every day for about 0.5h each time.

Condition after healing: the disease condition of the patient is improved after the patient uses the medicine for 1 week, and the disease condition is basically cured after the medicine is continued for 5 days.

3. Name: some grandchild, some woman, now 45 years old.

Disease condition: severe dandruff, itching, chunking dander, diagnosis of psoriasis vulgaris.

Dosage of the medicine: the head was rinsed daily with the feverfew drug prepared in example 32.

Condition after healing: the patient is not itchy and has no dandruff after 1 week of use.

4. Name: some Zhao, male, now 42 years old.

Disease condition: psoriasis is diagnosed 1 year ago, the whole body is itchy, the skin is removed, psoriasis vulgaris is diagnosed, and the medicine taking effect is not obvious.

Dosage of the medicine: the feverfew drug prepared in example 32 was applied by topical scrubbing. After improvement, the whole body is washed with water every day for about 0.5h each time.

Condition after healing: the symptoms of the patients are greatly improved after the patients use the medicine for 5 to 6 times, and the symptoms are basically healed after the medicine is continued for 14 days.

The foregoing description is only a preferred embodiment of the present invention, and is not intended to limit the embodiment of the present invention in any way, but any simple modification, equivalent variation and modification of the above embodiment according to the technical substance of the embodiment of the present invention still fall within the scope of the technical solution of the embodiment of the present invention.

Claims

1. The application of the Hexi chrysanthemum extract in preparing a medicinal preparation for treating psoriasis and pityriasis rosea is characterized in that the medicinal preparation is in the form of liniment, lotion and ointment;

the preparation method of the Hexi chrysanthemum extract comprises the following steps: adding water into the feverfew, extracting by adopting a reflux method, and filtering to obtain an extracting solution, namely the feverfew extract.

2. The use according to claim 1, wherein,

the pharmaceutical preparation comprises a feverfew extract and pharmaceutically acceptable auxiliary materials;

the auxiliary materials are at least one of gel framework materials, humectant, preservative, penetration enhancer, antioxidant, surfactant, propellant, thickener, ethanol and purified water.

3. The use according to claim 1, wherein,

the preparation method also comprises the following steps: concentrating under reduced pressure and/or removing impurities.

4. The use according to claim 3, wherein,

the temperature of the reduced pressure concentration is 40-85 ℃, and the reduced pressure concentration is carried out until the relative density is 1.05-1.30.

5. The use according to claim 4, wherein,

the preparation method of the liniment form pharmaceutical preparation comprises the following steps:

concentrating the extract under reduced pressure at 40-85 ℃ until the relative density is 1.05-1.30, thus obtaining the liniment-type pharmaceutical preparation.

6. The use according to claim 1, wherein the psoriasis is psoriasis vulgaris.