CN116077388A - Acne-removing Chinese herbal medicine composition and preparation method and application thereof - Google Patents
Acne-removing Chinese herbal medicine composition and preparation method and application thereof Download PDFInfo
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- CN116077388A CN116077388A CN202211540029.XA CN202211540029A CN116077388A CN 116077388 A CN116077388 A CN 116077388A CN 202211540029 A CN202211540029 A CN 202211540029A CN 116077388 A CN116077388 A CN 116077388A
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention discloses an acne-removing Chinese herbal medicine composition, a preparation method and application thereof, and belongs to the technical field of skin care products. The acne-removing Chinese herbal medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 0.1 to 10 parts of gynostemma pentaphylla, 6 to 30 parts of dandelion, 1 to 20 parts of weeping forsythia, 5 to 30 parts of rheum officinale, 3 to 25 parts of cortex toonae sinensis Radicis, 3 to 15 parts of turmeric, 3 to 15 parts of cortex phellodendri, 2 to 20 parts of rhizoma atractylodis, 2 to 20 parts of radix trichosanthis, 5 to 30 parts of sea buckthorn, 1 to 20 parts of dragon's blood and 3 to 15 parts of radix salviae miltiorrhizae. The Chinese herbal medicine composition has reasonable and scientific proportion of the components, multi-component and multi-target effect, and synergistic effect, achieves good acne removing, anti-inflammatory and antibacterial effects, and simultaneously can remarkably reduce the irritation to skin.
Description
Technical Field
The invention relates to the technical field of skin care products, in particular to an acne-removing Chinese herbal medicine composition, a preparation method and application thereof.
Background
The theory of acne is acne, also called "whelk", "pimple" or "comedo", which is a chronic inflammatory skin disease caused by obstruction of hair follicles and sebaceous glands and inflammation. Vaccinia often grows on the cheeks, forehead and mandible, and also on torso parts such as the chest, back and shoulder blades. Vaccinia is mainly characterized by acne, papules, pustules, nodules, cysts and scars, and is often accompanied by seborrhea, and hair and sebaceous glands can therefore accumulate excessive material, making grease and bacteria more prone to attachment.
The causes of acne are mainly related to androgen levels, increased sebum secretion, abnormal perifollicular cytokeratinization, hyperproliferation of propionibacterium acnes and inflammatory responses. Men and women of young age have vigorous androgen secretion due to physical development, while androgens cause sebaceous glands to produce more sebum, and the sebum and the exfoliated epidermal tissues are mixed to form substances like sediment to block pores, so that acne is caused.
At present, the clinical treatment of acne mainly uses antibiotics, and the medicines are divided into oral medicines and external medicines. The main external medicines are retinoids, benzoyl peroxide antibiotics and the like, and skin itch, molting and the like of patients sensitive to skin possibly occur in the medicines, so that small-scale trial can be performed before the medicines are used. The oral medicine is mainly antibiotics and isotretinoin. It should be noted that isotretinoin causes cyanosis of lips, desquamation, and elevation of blood lipid, and thus changes in blood, liver, and kidney functions are detected when isotretinoin is used. In addition, isotretinoin has teratogenic effect, and men and women of childbearing age should be contraception during the administration period, and can become pregnant after stopping administration for at least 3 months. Therefore, the clinical acne treatment medicines, whether external or internal, have side reaction hazards of different degrees.
At present, acid components such as salicylic acid, mandelic acid, azelaic acid and the like are generally adopted in the acne-removing cosmetics to strip and dissolve skin cutin layers, and the anti-inflammatory effect is utilized to inhibit the development of acne. These components have a corrosive stripping effect on skin barrier, so that the skin barrier is damaged, more than 65% of users who adopt acne-removing cosmetics with acid components for a long time can become sensitive muscles, skin sensitivity and allergy problems are generated, and more complex acne sensitive muscles are formed. And the clinical medicines and cosmetics adopt a surface anti-inflammatory treatment mode, so that the cause of acne cannot be really solved.
According to the combined investigation of the dermatology association and the national teenager association, the incidence of the acne in China is in an annual rising trend, more than 80 percent of people encounter the acne problem, and the incidence of the acne with more serious illness is more than 1/3 of the young people. Wherein the acne patients of middle school students are 2.94 hundred million, the acne patients of college students are 1.33 hundred million, the acne patients of office workers over 25 years old are 1.27 hundred million, and the total number of three people is 5.5 hundred million. According to the authority statistics of the ministry of health in China, the complete cure rate of acne in China is only 32.95%, and the market is in urgent need of an acne removing product which can be used for a long time and is mild in long time and free of side effects.
The invention patent with application publication number of CN 113350401A discloses an acne-removing and skin-cleaning cream, which comprises the following raw materials in parts by weight: 5-15 parts of rheum officinale, 5-15 parts of sulfur, 5-15 parts of coptis chinensis, 5-15 parts of radix angelicae, 5-15 parts of spina gleditsiae, 5-15 parts of radix trichosanthis and 3-9 parts of borneol. The acne-removing and skin-cleaning cream can not repair skin barrier.
Disclosure of Invention
The invention provides a Chinese herbal medicine composition for removing acnes, which achieves the purposes of removing acnes, relieving skin and repairing skin barriers.
The second aim of the invention is to provide a preparation method of the acne-removing Chinese herbal medicine composition.
The third aim of the invention is to provide an application of the acne-removing Chinese herbal medicine composition.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows: the acne-removing Chinese herbal medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 0.1 to 10 parts of gynostemma pentaphylla, 6 to 30 parts of dandelion, 1 to 20 parts of weeping forsythia, 5 to 30 parts of rheum officinale, 3 to 25 parts of cortex toonae sinensis Radicis, 3 to 15 parts of turmeric, 3 to 15 parts of cortex phellodendri, 2 to 20 parts of rhizoma atractylodis, 2 to 20 parts of radix trichosanthis, 5 to 30 parts of sea buckthorn, 1 to 20 parts of dragon's blood and 3 to 15 parts of radix salviae miltiorrhizae.
Further, the composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 0.1 to 5 parts of gynostemma pentaphylla, 6 to 18 parts of dandelion, 3 to 16 parts of weeping forsythia, 8 to 20 parts of rheum officinale, 6 to 18 parts of cortex toonae sinensis Radicis, 5 to 12 parts of turmeric, 5 to 12 parts of phellodendron bark, 6 to 16 parts of rhizoma atractylodis, 6 to 16 parts of radix trichosanthis, 8 to 20 parts of sea buckthorn, 3 to 13 parts of dragon's blood and 5 to 12 parts of radix salviae miltiorrhizae.
A method for preparing Chinese herbal medicine composition for eliminating acne comprises soaking herba Gynostemmatis, herba Taraxaci, fructus forsythiae, radix et rhizoma Rhei, cortex Ailanthi, curcuma rhizome, cortex Phellodendri, rhizoma Atractylodis, radix Trichosanthis, fructus Hippophae, saviae Miltiorrhizae radix and sanguis Draxonis, heating, concentrating, and filtering to obtain Chinese herbal medicine composition.
A preparation method of a Chinese herbal medicine composition for removing acnes comprises the following steps of adding 8-12 times of water into gynostemma pentaphylla, dandelion, fructus forsythiae, rheum officinale, cortex ailanthi, turmeric, phellodendron bark, rhizoma atractylodis, radix trichosanthis, sea buckthorn, radix salviae miltiorrhizae and resina draconis to soak for 0.5-1.5 hours, heating and boiling for 1-2 hours to obtain an extracting solution, centrifuging the extracting solution to obtain a centrifugate, concentrating the centrifugate at 80-85 ℃ until the solid content of the centrifugate is 3.5% -4.0%, stopping concentrating to obtain a concentrated solution, and filtering the concentrated solution to obtain the Chinese herbal medicine composition.
An application of a Chinese herbal medicine composition for removing acnes, wherein the Chinese herbal medicine composition can be made into cream, emulsion, essence or facial mask.
Further, the essence comprises the following raw materials of water, glycerol, hexanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, vitamin E, polydimethylsiloxane, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer and the Chinese herbal medicine composition.
Further, the preparation method of the essence comprises the following steps:
1) Adding water, glycerol, hexanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer and the Chinese herbal medicine composition into a container I, heating and stirring to obtain an intermediate product I;
2) Adding vitamin E and polydimethylsiloxane into a second container, heating and stirring to obtain a second intermediate product;
3) And transferring the intermediate product II in the container II into the container I, and stirring with the intermediate product I to obtain the essence.
Further, the spot-on essence comprises the following raw materials of water, glycerol, propylene glycol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, sodium hyaluronate, sodium hydroxide solution, phenoxyethanol, chlorpheniramine and the Chinese herbal medicine composition.
Further, the preparation method of the spot-on essence comprises the following steps:
1) Adding water, glycerol, propylene glycol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, sodium hyaluronate and Chinese herbal medicine composition into a container III, and stirring to obtain an intermediate product III;
2) And adding sodium hydroxide solution, phenoxyethanol and chlorphenyl glycinate into a container III, and stirring with the intermediate product III to obtain the spot-coating essence.
Advantageous effects
The efficacy of each drug of the invention is as follows:
fructus forsythiae
Sex taste: bitter and cool.
(1) Book of changes: bitter and flat.
(2) The miscellaneous records: is nontoxic.
(3) Medical Start Source (S): it is cool in nature and bitter in flavor, mainly in Yun from Yi Jue.
(4) Compendium, compendium: slightly bitter and pungent.
Channel tropism: enter heart, liver and gallbladder meridians.
(1) Soup materia medica (soup materia Medica): the febrile yang of the hands and feet and the yangming meridians.
(2) Compendium, compendium: the heart meridian of shaoyin and jueyin envelop qi-flowing.
(3) Medicine property solution for processing Tripterygium wilfordii: enters the six meridians of the heart, liver, gallbladder, stomach, triple energizer and large intestine.
The main functions are as follows: clearing heat, detoxicating, resolving hard mass and detumescence. For warm heat, erysipelas, macula, carbuncle, ulcer, swelling and toxicity, scrofula and urine stranguria.
(1) Book of changes: the main cold and heat, the flaccidity of mice, scrofula, carbuncles, sores, gall, and heat accumulation.
(3) Drug Property theory (L): the main body is to treat five stranguria, and the symptoms of difficult urination and heart and heat.
(4) Japanese Sunji (Japanese Subtu) grass: to dredge the small intestine and drain pus. It can be used for treating sore and furuncle, relieving pain, and dredging menstruation.
(5) The preparation method comprises the following steps: dispersing menstrual blood and qi accumulation; detumescence.
Antipyretic effect: the fructus forsythiae decoction or compound fructus forsythiae injection has cooling effect on body temperature of artificially febrile animals and normal animals.
Anti-inflammatory action: 50% of the forsythia alcohol extract aqueous solution is injected into 20ml/kg of the abdominal cavity, so that the forsythia alcohol extract aqueous solution has very obvious anti-exudation effect on the croton oil-based granulosa sac of rats, has the effect of reducing the fragility of the capillary wall of inflammatory foci, can promote the formation of inflammatory barriers, and 300% of the forsythia injection solution is injected into 30-40 g/kg of the abdominal cavity, so that the forsythia alcohol extract aqueous solution has obvious inhibition effect on egg white foot edema of rats; can also promote phagocytosis of mouse inflammatory cells.
Anti-pathogenic microbial action: the fructus forsythiae has inhibiting effect on various gram-positive and gram-negative bacteria, and the concentrated decoction can inhibit typhoid bacillus, paratyphoid bacillus, escherichia coli, shigella dysenteriae, diphtheria bacillus, vibrio cholerae, staphylococcus, streptococcus and the like in vitro, and the antibacterial effect of the fructus forsythiae in vitro is similar to that of honeysuckle; the antibacterial agent has the main antibacterial component in the Yinqiao powder, the inhibition effect of honeysuckle on salmonella, especially typhoid bacillus and hemolytic streptococcus is superior to that of weeping forsythia, and the inhibition effect of honeysuckle on shigella dysenteriae and staphylococcus aureus is superior to that of weeping forsythia.
Dandelion
Sex taste: bitter, sweet and cold.
(1) Tang Ben Cao (Tang Ben Cao): sweet, flat and nontoxic.
(2) The preparation method comprises the following steps: slightly bitter and cold.
(3) Materia medica description: sweet, flat and slightly cold.
(4) A handbook of commonly used Chinese herbal medicines: bitter, sweet and cold.
Channel tropism: enter the liver and stomach meridians.
(1) The preparation method comprises the following steps: the foot's shaoyin meridian.
(2) Materia medica derived sense and complement: enters the yangming and taiyin meridians.
The main functions are as follows: clearing away heat and toxic materials, promoting urination and resolving hard mass. Can be used for treating acute mastitis, lymphadenitis, scrofula, furuncle, conjunctivitis, common cold, fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.
(1) Tang Ben Cao (Tang Ben Cao): mainly women's mammary abscess swelling.
(2) The book of materia medica drawing channel: applied sore, it is indicated for malignant thorn and fox urine thorn.
(3) Materia medica derived sense and complement: remove heat toxin, eliminate malignant tumor and tuberculosis, remove food toxin, and remove stagnation of qi.
(4) Yunnan Ben Cao (materia Medica): applied on sores and toxic swelling, scabies and scabies, tinea and sores; dispelling wind, eliminating sore and toxic materials, and eliminating scrofula and tuberculosis; relieve hematochezia, treat five stranguria, uroschesis and promote urination.
(5) Medicine codification: tonify spleen and stomach, purge fire, promote lactation and treat dysphagia.
(6) Compendium mu Shiyi (compendium mu Yi): treat all venomous snake injuries.
(7) Diet Spectrum with rest: clearing lung-heat, relieving cough, resolving phlegm, resolving masses, resolving carbuncles, nourishing yin, cooling blood, relaxing tendons, consolidating teeth, promoting lactation and replenishing essence.
(8) Ling nan gatherer: is used for treating epigastralgia by being taken with wine after being roasted and stored in friable.
(9) "Shandong traditional Chinese medicine: is a medicine for detoxication, anti-inflammation and heat clearing. For jaundice, conjunctival congestion, difficult urination and constipation.
A common Chinese herbal medicine handbook: clear away heat and toxic materials, cool blood, induce diuresis, and promote lactation. It can be used for treating furuncle, skin ulcer, eye diseases, dyspepsia, constipation, snake and insect bite, and urinary tract infection.
Radix Salviae Miltiorrhizae
Has effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood, and resolving carbuncle. Can be used for treating chest pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease.
Efficacy: promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing heart fire, relieving restlessness, cooling blood and resolving carbuncle.
Clinical application: (1) compendium of materia Medica: promoting blood circulation, removing obstruction in the heart, and treating hernia.
(2) Book of changes: pathogenic qi in the heart and abdomen, borborygmus, cold and heat accumulation, break symptoms, remove obstruction, stop restlessness and fullness, and benefit qi.
(3) The miscellaneous records: blood nourishing, heart and abdomen disease removing, qi stagnation eliminating, waist and spine strengthening, foot obstruction eliminating, pathogenic wind and heat retaining. Is beneficial for people after long-term administration.
(4) Burning the hot oil fire, removing pain and promoting tissue regeneration: the eight two files of red sage root are fine-tuned with water, and two jin of mutton fat are taken and decocted three times up and three times down to be applied on sores. ("elbow rear
Gynostemma Pentaphyllum Makino
The gynostemma pentaphylla and the lucid ganoderma are matched for boiling water or making tea for drinking, so that the symptoms such as hypertension, hyperlipidemia, hyperglycemia, fatty gynostemma pentaphylla liver and the like can be treated. Has effects of protecting liver, removing toxic substances, lowering blood pressure, and reducing blood lipid and blood sugar.
The main effective components of herba Gynostemmatis comprise herba Gynostemmatis saponin, herba Gynostemmatis glucoside (polysaccharide), water-soluble amino acids, flavonoids, vitamins, microelements, minerals, etc.
Medicinal material base source: is the whole herb of gynostemma pentaphylla belonging to Cucurbitaceae.
Sex taste: slightly sweet; it is cool in nature.
Channel tropism: lung-returning; spleen; kidney meridian.
Efficacy: replenishing qi to invigorate the spleen, resolving phlegm to arrest cough, clearing away heat and toxic materials.
Efficacy classification: deficiency tonifying medicine; phlegm-resolving medicine; heat-clearing herbs.
The main indications are: deficiency and weakness; consumptive disease failing to control essence; leukopenia; hyperlipidemia; viral hepatitis; chronic gastroenteritis; chronic tracheitis.
Radix et rhizoma Rhei
The Chinese medicine rhubarb has the effects of removing stagnation, clearing damp-heat, purging fire, cooling blood, removing blood stasis, detoxifying and the like.
Sex taste: bitter and cold.
Channel tropism: stomach channel; large intestine channel; liver meridian; spleen meridian.
Classification of genus of family: polygonaceae (Polygonaceae)
Efficacy: (1) purgation and accumulation attack: can be used for treating gastrointestinal excessive heat accumulation, constipation, abdominal distention and abdominal pain, etc., such as (typhoid theory < large qi-bearing decoction >), < small qi-bearing decoction >, (Qianjin Fang < warm spleen decoction >), and (typhoid six books < Huanglong decoction >).
(2) Purging fire and detoxifying: for vomiting and epistaxis due to excessive heat and fire, such as heart-purging decoction (jin Kui Yao Lloyd decoction).
(3) Promoting blood circulation to remove blood stasis: can be used for treating various stasis syndrome, such as < recovery blood-activating decoction >.
(4) Clear away damp-heat: can guide damp-heat to be discharged from the stool. It is mainly indicated for jaundice and stranguria, such as < herba Artemisiae Scopariae decoction >, < eight-positive powder >.
The main indications are: constipation due to excessive heat; chest stuffiness due to heat accumulation; diarrhea due to damp-heat; jaundice; gonorrhea; edema and abdominal fullness; dysuria; conjunctival congestion; sore throat; sores of the mouth and tongue; vomiting due to stomach heat; hematemesis; hemoptysis; epistaxis blood; hematochezia; hematuria; storing blood; amenorrhea; postpartum abdominal pain due to blood stasis; mass of the mass; traumatic injury; carbuncle and ulcer due to heat toxin; erysipelas; and (3) scalding.
Cortex toonae sinensis Radicis
Sex taste: bitter, astringent and cold.
Channel tropism: it enters large intestine, stomach and liver meridians.
The main functions are as follows: clear heat and dry dampness, astringe and stop leukorrhagia, check diarrhea and stop bleeding. Can be used for treating leucorrhea with red and white discharge, damp-heat dysentery, chronic diarrhea, hematochezia, metrorrhagia.
(Curcuma longa)
Sex taste: pungent and bitter taste and warm.
Channel tropism: enters the spleen and liver meridian.
The main functions are as follows: break blood, promote qi circulation, promote menstruation and relieve menalgia. For treating distending pain in the heart and abdomen, arm pain, abdominal mass, amenorrhea due to blood stasis, postpartum abdominal pain due to stasis, traumatic injury, and carbuncle. Rhizoma corydalis and rhizoma Cyperi are often used for chest and abdominal pain, dysmenorrhea and limb pain due to qi stagnation and blood stasis.
Huang Bai
Sex taste: bitter in flavor and cold in nature.
The main functions are as follows: clear away heat and toxic materials, purge fire and remove dampness. Acute bacillary dysentery, acute enteritis, acute icteric hepatitis, urinary system infection, etc. It can be used for treating burn, scald, otitis media, and acute conjunctivitis.
Rhizoma atractylodis
Root stem (rhizoma Atractylodis): pungent and bitter, warm.
The main functions are as follows: dry dampness, invigorate spleen, expel wind and remove cold, improve eyesight and remove dirt. Can be used for treating abdominal distention and pain, diarrhea, edema, rheumatalgia, tinea pedis , common cold due to wind-cold, and sparrow eyes.
Radix Trichosanthis
Sex taste: sweet, slightly bitter and slightly cold.
Channel tropism: enter lung and stomach meridians.
The main functions are as follows: is a heat-clearing and fire-purging medicine, and has the specific effects of clearing heat, purging fire, promoting fluid production, quenching thirst, expelling pus and detumescence. It can be used for treating fever, thirst, diabetes, jaundice, lung dryness, hemoptysis, carbuncle, swelling, and hemorrhoid. For treating diabetes mellitus, it is often used together with yin-nourishing medicines to achieve the effect of treating both principal and secondary aspect of disease.
Sea buckthorn fruit
The main functions are as follows: cough relieving, phlegm eliminating, digestion promoting, stagnation resolving, blood circulation promoting and blood stasis dispelling effects. Can be used for treating cough, excessive phlegm, dyspepsia, abdominal pain, traumatic injury, blood stasis, swelling, and amenorrhea due to blood stasis.
Dragon's blood
Sex taste: sweet in taste; salty; sex level; small toxicity.
Efficacy classification: external use medicine; blood circulation activating and stasis removing medicine; removing blood stasis and relieving pain; hemostasis; promoting tissue regeneration and healing sore.
The traditional Chinese medicine considers that the cause of acne is lung and stomach heat, damp evil accumulation and heat toxin accumulation, so the traditional Chinese medicine treatment method for acne generally comprises the steps of moistening lung, clearing heat, strengthening spleen, promoting diuresis, clearing heat, cooling blood, clearing heat, detoxicating, activating blood and dissolving stasis. The radix trichosanthis has the effects of moistening lung and clearing heat; dandelion, fructus forsythiae, rheum officinale, cortex ailanthi, phellodendron bark and gynostemma pentaphylla have the effects of clearing heat, removing toxicity, reducing swelling and resolving masses; the rheum officinale, the cortex toonae sinensis Radicis and the phellodendron bark have the effects of clearing heat and cooling blood; the dragon's blood, turmeric and red sage root have the effects of activating blood and dissolving stasis; the Chinese herbal medicine composition used in the invention has the effects of strengthening spleen and promoting diuresis, so that acne can be well treated.
The acne-removing Chinese herbal medicine composition disclosed by the invention has the advantages that the proportion of each component is reasonable and scientific, the effects of multiple components and multiple targets are achieved, the synergy is achieved, the good acne-removing, anti-inflammatory and antibacterial effects are achieved, meanwhile, the irritation to the skin can be obviously reduced, and the acne-removing Chinese herbal medicine composition can be used for preventing acne, eliminating acne, relieving inflammation caused by acne and the like.
The acne-removing Chinese herbal medicine composition is refined by water extraction, so that the effective components of the small molecules of the traditional Chinese medicine are combined with the dosage form of the external skin care product, are easier to penetrate the surface layer of the skin and are absorbed, enter the deep organism circulation, effectively regulate internal secretion in the body, and are externally used for internal regulation, thereby fundamentally solving the problem of acne.
The acne-removing Chinese herbal medicine composition is prepared from Chinese herbal medicines, has a mild formula, does not generate toxic or side effect, and has no irritation to skin.
The essence, cream and the like provided by the acne-removing Chinese herbal medicine composition contain efficient moisturizing components, can effectively moisten skin, and enable the skin to be fresh and moist in the process of preventing, alleviating and eliminating acne.
The essence, cream and the like provided by the acne-removing Chinese herbal medicine composition not only meet the acne-removing effect, but also have the effects of preventing and relieving, and improve the tolerability of skin.
Detailed Description
The technical solution of the present invention will be clearly and completely described in conjunction with the specific embodiments, but it should be understood by those skilled in the art that the embodiments described below are only for illustrating the present invention and should not be construed as limiting the scope of the present invention. All other embodiments, which can be made by one of ordinary skill in the art without undue burden on the person of ordinary skill in the art based on the embodiments of the present invention, are within the scope of the present invention.
The experimental methods used in the following examples are conventional methods unless otherwise specified. Materials, reagents and the like used in the examples described below are commercially available unless otherwise specified.
Example 1
The acne-removing Chinese herbal medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 0.1 part of gynostemma pentaphylla, 6 parts of dandelion, 1 part of fructus forsythiae, 5 parts of rheum officinale, 3 parts of cortex ailanthi, 3 parts of turmeric, 3 parts of cortex phellodendri, 2 parts of rhizoma atractylodis, 2 parts of radix trichosanthis, 5 parts of sea buckthorn, 1 part of dragon's blood and 3 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 8 times of water by mass, soaked for 0.5h, heated, boiled for 1h and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 80deg.C, and stopping concentrating until the solid content is 3.5%, to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Example 2
The acne-removing Chinese herbal medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 10 parts of gynostemma pentaphylla, 30 parts of dandelion, 20 parts of fructus forsythiae, 20 parts of rheum officinale, 25 parts of cortex ailanthi, 8 parts of turmeric, 15 parts of phellodendron, 20 parts of rhizoma atractylodis, 20 parts of radix trichosanthis, 20 parts of sea buckthorn, 20 parts of dragon's blood and 15 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 12 times of water by mass, soaked for 1.5 hours, heated, boiled for 2 hours and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 85deg.C until the solid content is 4.0%, and stopping concentrating to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Example 3
The acne-removing Chinese herbal medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4 parts of gynostemma pentaphylla, 12 parts of dandelion, 10 parts of fructus forsythiae, 12 parts of rheum officinale, 14 parts of cortex ailanthi, 8 parts of turmeric, 6 parts of cortex phellodendri, 6 parts of rhizoma atractylodis, 8 parts of radix trichosanthis, 14 parts of sea buckthorn, 7 parts of dragon's blood and 8 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 10 times of water by mass, soaked for 1 hour, heated, boiled slightly for 1.5 hours and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 83 deg.C until the solid content is 3.8%, and stopping concentrating to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
In the application of the acne-removing Chinese herbal medicine composition of the embodiment, the preparation formula of the essence is shown in table 1:
table 1 preparation formulation of essence
The preparation method of the essence for the application of the acne-removing Chinese herbal medicine composition comprises the following steps:
1) Sequentially adding water, glycerol, hexanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer and Chinese herbal medicine composition into an emulsifying tank, heating and stirring at 30r/min, heating to 80deg.C, homogenizing for 5min, homogenizing at 2500r/min, vacuum degassing, vacuum degree of-0.04 MPa, maintaining for 10min, and uniformly stirring to obtain intermediate product I. The ammonium acryloyldimethyl taurate/VP copolymer is derived from Clariant Laien company.
2) And adding the vitamin E and the polydimethylsiloxane into an oil pot, heating and stirring at the stirring speed of 30r/min, heating to 80 ℃, and stirring until the vitamin E and the polydimethylsiloxane are uniformly dispersed to obtain an intermediate product II. Polydimethylsiloxane was derived from Zhejiang Runner silicone New Material Co.
3) And (3) sucking the intermediate product II in the oil pan into the emulsifying tank and stirring the intermediate product one by one, wherein the stirring speed is 30r/min, the homogenizing speed is 5min, the homogenizing speed is 2500r/min, the vacuum degassing is carried out, the vacuum degree is-0.04 MPa, the maintaining is carried out for 30min, then the temperature is reduced to 35 ℃, and the essence is obtained by filling the reduced temperature into a packaging bottle.
In the application of the acne-removing Chinese herbal medicine composition of the embodiment, the preparation formula of the spot-on essence is shown in table 2:
table 2 preparation formulation of spot-on essence
In the application of the acne-removing Chinese herbal medicine composition of the embodiment, the preparation method of the spot-coating essence comprises the following steps:
1) Adding water, glycerol, propylene glycol, acrylic acid (esters) C10-30 alkanol acrylate crosslinked polymer, sodium hyaluronate and Chinese herbal medicine composition into an emulsifying tank, stirring at a stirring speed of 30r/min, homogenizing for 5min, homogenizing at a homogenizing speed of 2500r/min, vacuum degassing at a vacuum degree of-0.04 MPa, and maintaining for 10min to obtain an intermediate product III after stirring uniformly;
2) Adding sodium hydroxide solution into an emulsifying tank, stirring with the intermediate product III at the stirring speed of 30r/min, confirming stirring uniformity, adding phenoxyethanol and chlorphenicol, stirring at the stirring speed of 30r/min, and filling into a packaging bottle to obtain the spot-coating essence.
Comparative example 1
The acne-removing Chinese herbal medicine composition of the comparative example is prepared from the following traditional Chinese medicine raw materials in parts by weight:
4 parts of gynostemma pentaphylla, 12 parts of dandelion, 10 parts of fructus forsythiae, 12 parts of rheum officinale, 14 parts of cortex ailanthi, 8 parts of turmeric, 6 parts of cortex phellodendri, 6 parts of rhizoma atractylodis, 14 parts of sea buckthorn, 7 parts of dragon's blood and 8 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition of the comparative example comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 8 times of water by mass, soaked for 0.5h, heated, boiled for 1h and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 80deg.C, and stopping concentrating until the solid content is 3.5%, to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Comparative example 2
The acne-removing Chinese herbal medicine composition of the comparative example is prepared from the following traditional Chinese medicine raw materials in parts by weight: 8 parts of turmeric, 6 parts of rhizoma atractylodis, 8 parts of radix trichosanthis, 14 parts of sea buckthorn, 7 parts of dragon's blood and 8 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition of the comparative example comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 8 times of water by mass, soaked for 0.5h, heated, boiled for 1h and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 80deg.C, and stopping concentrating until the solid content is 3.5%, to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Comparative example 3
The acne-removing Chinese herbal medicine composition of the comparative example is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4 parts of gynostemma pentaphylla, 12 parts of dandelion, 10 parts of fructus forsythiae, 8 parts of turmeric, 6 parts of rhizoma atractylodis, 8 parts of radix trichosanthis, 14 parts of sea buckthorn, 7 parts of dragon's blood and 8 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition of the comparative example comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 12 times of water by mass, soaked for 1.5 hours, heated, boiled for 2 hours and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 85deg.C until the solid content is 4.0%, and stopping concentrating to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Comparative example 4
The acne-removing Chinese herbal medicine composition of the comparative example is prepared from the following traditional Chinese medicine raw materials in parts by weight: 4 parts of gynostemma pentaphylla, 12 parts of dandelion, 10 parts of fructus forsythiae, 12 parts of rheum officinale, 14 parts of cortex ailanthi, 6 parts of cortex phellodendri, 6 parts of rhizoma atractylodis, 8 parts of radix trichosanthis and 14 parts of sea buckthorn.
The preparation method of the acne-removing Chinese herbal medicine composition of the comparative example comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 12 times of water by mass, soaked for 1.5 hours, heated, boiled for 2 hours and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 85deg.C until the solid content is 4.0%, and stopping concentrating to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Comparative example 5
The acne-removing Chinese herbal medicine composition of the comparative example is prepared from the following traditional Chinese medicine raw materials in parts by weight:
4 parts of gynostemma pentaphylla, 10 parts of fructus forsythiae, 12 parts of rheum officinale, 8 parts of turmeric, 8 parts of radix trichosanthis, 7 parts of dragon's blood and 8 parts of radix salviae miltiorrhizae.
The preparation method of the acne-removing Chinese herbal medicine composition of the comparative example comprises the following steps: the acne-removing Chinese herbal medicine composition of the embodiment is added with 10 times of water by mass, soaked for 1 hour, heated, boiled slightly for 1.5 hours and discharged. Centrifuging the Chinese herbal medicine extract at high speed, removing the fine residues to obtain Chinese herbal medicine centrifugate, vacuum concentrating the Chinese herbal medicine centrifugate at 83 deg.C until the solid content is 3.8%, and stopping concentrating to obtain Chinese herbal medicine concentrate. Filtering the Chinese herbal medicine concentrated solution to obtain the Chinese herbal medicine composition. The pore diameter of the filter element is 1 μm when the Chinese herbal medicine concentrated solution is filtered.
Experimental example 1
After the patch test, the herbal compositions prepared in examples 1, 2, 3, 4, and 5 were prepared as spot-on essences for the test cases, and then the acne sizes of the VISIA-CR and skin red pigment probe Mexameter MX18 test cases were analyzed by facial image, and the test results are shown in Table 3.
TABLE 3 degree of acne reduction
As can be seen from table 3, the control group and the experimental group were significantly different in the degree of acne improvement. Wherein, the acne improvement degree corresponding to the embodiment 3 is far greater than that of the embodiments 1-2 and the comparative examples 1-5, which shows that the acne removing effect of the embodiment is better.
Experimental example 2
The herbal composition of example 3 was prepared as a serum and a spot-on serum, and the serum and the spot-on serum were compared using the serum and the spot-on serum of example 3.
Experimental instrument: face image analysis VISIA-CR, skin red pigment probe Mexameter MX18.
The experimental method comprises the following steps: the results of the human body efficacy use tests of the essence and the spot-on essence, which were made of the high-concentration traditional Chinese medicine composition and used for 28 days for 30 subjects with obvious acne observed through the VISIA-CR image, are shown in Table 4 and Table 5 respectively.
Table 4 results of human efficacy use test of essence
The effect is shown: acne is significantly reduced compared with 28 days ago, and red pigment is significantly reduced
The method is effective: acne is reduced by a small amount compared with 28 days ago, and red pigment is reduced
Invalidation: acne and red pigment have no obvious change
Table 5 results of human efficacy application test of spot-on essence
The effect is shown: acne is significantly reduced compared with 28 days ago, and red pigment is significantly reduced
The method is effective: acne is reduced by a small amount compared with 28 days ago, and red pigment is reduced
Invalidation: acne and red pigment have no obvious change
While the invention has been described in detail in the foregoing general description and specific examples, it will be apparent to those skilled in the art that modifications and improvements can be made thereto. Accordingly, such modifications or improvements may be made without departing from the spirit of the invention and are intended to be within the scope of the invention as claimed.
Claims (9)
1. The acne-removing Chinese herbal medicine composition is characterized by comprising the following traditional Chinese medicine raw materials in parts by weight: 0.1 to 10 parts of gynostemma pentaphylla, 6 to 30 parts of dandelion, 1 to 20 parts of weeping forsythia, 5 to 30 parts of rheum officinale, 3 to 25 parts of cortex toonae sinensis Radicis, 3 to 15 parts of turmeric, 3 to 15 parts of cortex phellodendri, 2 to 20 parts of rhizoma atractylodis, 2 to 20 parts of radix trichosanthis, 5 to 30 parts of sea buckthorn, 1 to 20 parts of dragon's blood and 3 to 15 parts of radix salviae miltiorrhizae.
2. The acne-removing Chinese herbal medicine composition according to claim 1, wherein the composition comprises the following traditional Chinese medicine raw materials in parts by weight: 0.1 to 5 parts of gynostemma pentaphylla, 6 to 18 parts of dandelion, 3 to 16 parts of weeping forsythia, 8 to 20 parts of rheum officinale, 6 to 18 parts of cortex toonae sinensis Radicis, 5 to 12 parts of turmeric, 5 to 12 parts of phellodendron bark, 6 to 16 parts of rhizoma atractylodis, 6 to 16 parts of radix trichosanthis, 8 to 20 parts of sea buckthorn, 3 to 13 parts of dragon's blood and 5 to 12 parts of radix salviae miltiorrhizae.
3. The method for preparing an anti-acne Chinese herbal medicine composition according to claim 1, wherein the formula amount of gynostemma pentaphylla, dandelion, fructus forsythiae, rheum officinale, cortex ailanthi sinensis, turmeric, phellodendron bark, rhizoma atractylodis, radix trichosanthis, sea buckthorn, radix salviae miltiorrhizae and resina draconis are soaked, heated, concentrated and filtered to obtain the Chinese herbal medicine composition.
4. The method for preparing the acne-removing Chinese herbal medicine composition according to claim 3, wherein the formula amount of gynostemma pentaphylla, dandelion, fructus forsythiae, rheum officinale, cortex toonae sinensis Radicis, turmeric, phellodendron bark, rhizoma atractylodis, radix trichosanthis, sea buckthorn, radix salviae miltiorrhizae and resina draconis is added into 8-12 times of water for soaking for 0.5-1.5 hours, then the mixture is heated and boiled for 1-2 hours, the extract is obtained after heating, the extract is centrifuged to obtain a centrifugate, the centrifugate is concentrated at 80-85 ℃, the concentration is stopped after the solid content of the centrifugate is 3.5% -4.0%, and the concentrate is filtered to obtain the Chinese herbal medicine composition.
5. Use of a Chinese herbal composition for acne treatment according to any one of claims 1 to 4, wherein the composition is formulated as a cream, lotion, serum, spot-on serum or mask.
6. The use of the anti-acne herbal composition according to claim 5, wherein the essence comprises water, glycerin, hexylene glycol, sodium hyaluronate, hydrolyzed sodium hyaluronate, vitamin E, polydimethylsiloxane, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer, and the herbal composition.
7. The use of the acne-removing herbal composition as claimed in claim 6, wherein the preparation method of the essence comprises the following steps:
1) Adding water, glycerol, hexanediol, sodium hyaluronate, hydrolyzed sodium hyaluronate, p-hydroxyacetophenone, ammonium acryloyldimethyl taurate/VP copolymer and the Chinese herbal medicine composition into a container I, heating and stirring to obtain an intermediate product I;
2) Adding vitamin E and polydimethylsiloxane into a second container, heating and stirring to obtain a second intermediate product;
3) And transferring the intermediate product II in the container II into the container I, and stirring with the intermediate product I to obtain the essence.
8. The use of the anti-acne Chinese herbal medicine composition according to claim 5, wherein the spot-on essence comprises the following raw materials of water, glycerol, propylene glycol, acrylic acid (esters)/C10-30 alkanol acrylate cross-linked polymer, sodium hyaluronate, sodium hydroxide solution, phenoxyethanol, chlorpheniramine and the Chinese herbal medicine composition.
9. The use of the acne-removing herbal composition as claimed in claim 8, wherein the preparation method of the spot-on essence comprises the following steps:
1) Adding water, glycerol, propylene glycol, acrylic acid (esters) and C10-30 alkanol acrylate cross-linked polymer, sodium hyaluronate and Chinese herbal medicine composition into a container III, and stirring to obtain an intermediate product III;
2) And adding sodium hydroxide solution, phenoxyethanol and chlorphenyl glycinate into a container III, and stirring with the intermediate product III to obtain the spot-coating essence.
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