CN106038873A - Traditional Chinese medicine composition, traditional Chinese medicine preparation and clear paste for treating acne and whelk and preparation method - Google Patents
Traditional Chinese medicine composition, traditional Chinese medicine preparation and clear paste for treating acne and whelk and preparation method Download PDFInfo
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The invention relates to the technical field of skin care through traditional Chinese medicine, in particular to a traditional Chinese medicine composition for treating acne and whelk and application thereof. The traditional Chinese medicine composition is composed of, by weight, 2-4 parts of extract of Fructus forsythiae, 2-4 parts of extract of dandelion, 2-4 parts of extract of Herba violae, 2-4 parts of extract of Salvia miltiorrhiza, 2-4 parts of extract of Cortex lycii, 2-4 parts of extract of Flos chrysanthemi indici, 3-5 parts of extract of Radix glycyrrhizae, 3-5 parts of extract of Radix bupleuri, 3-5 parts of extract of Semen cassiae, 3-5 parts of extract of aloe, 3-5 parts of extract of mulberry leaf and 3-5 parts of extract of mint. The traditional Chinese medicine composition can be used for preparing skin-care cosmetics for treating acne and whelk, active ingredients are synergistic and jointly function in clearing lung heat, dispelling wind heat, cooling and activating blood and dispersing stasis to subside swelling, the traditional Chinese medicine composition can improve and adjust environment in skin cells and can treat whelk from outside to inside, and the problem that the whelk is prone to reoccurrence is solved safely and enduringly.
Description
Technical field
The present invention relates to Chinese medicinal skin care technical field, be specifically related to a kind of treat acne whelks Chinese medicine composition, in
Medicine preparation, clear paste, preparation method.
Background technology
Although acne and comedo are grown in skin surface, but closely bound up with the imbalance of dirty pulmonary function, there is acne or green grass or young crops
Spring pox is due to human endocrine dysfunction, and androgen secretion is hyperfunction, and sebaceous gland activity is abnormal, causes sebum secretion to increase,
Follicular orifice hyperkeratosis so that it is sebum outflow is not smooth, abnormal flora grows and causes a disease.Raising and people along with people's quality of the life
For beautiful pursuit, the kind of cosmetics can be described as getting more and more, and product for resolving poxes in the market is more universal,
But most of product for resolving poxes all contains chemical substance, even in order to improve anti-acne timeliness, is also added with using some to swash
Disposition composition, all skin have certain zest, long-time use that skin can be caused allergy or acne and comedo occur repeatedly
The side effect increased the weight of, can make hair follicle block, and even can cause erythema, increases organism body constitution sensitization, causes anaphylactic reaction
Danger.Therefore, research and develop there is good safety, stability, inhibition is obvious, cost performance is good natural therapeutic
Acne and the product of comedo, it has also become one of main direction of studying of current medicine and cosmetic industry.
Chinese medicine has no side effect owing to it is natural, is applied in cosmetics and medicine can reach skin treating and the dual merit of skin protection
Effect, and gradually pursued by people.The traditional Chinese medical science thinks generation acne or comedo is many and eating and drinking without temperance, and surfeit is pungent and delicious food is thick
Taste, feels exopathogen again, makes hair follicle inaccessible, and interior-heat must not reach thoroughly, causes heat in blood to be accumulate and steams in face, or lung meridian intrinsic heat, inside accumulate steam in
Face and formed.Acne and comedo disease are divided into four kinds of common diseases by the traditional Chinese medical science, and one is hepatic depression combined symptoms, is more common in female
Son, erythra recurrent exerbation, there is obvious relation with menstrual cycle；Two is damp-heat in the spleen and stomach disease, skin disease redness pruritus, is often accompanied by defecating not
Freely, dyspepsia, abdominal distention, yellow and greasy fur, the symptom such as slippery and rapid pulse；Three is lung-wind syndrome heat symptom-complex, shows as Blushing, acne heat, scabies
Itch, or have the symptoms such as pustule, yellow and thin fur, red tongue, thready and rapid pulse；Four is hepatic and renal YIN deficiency disease, is more common in the adult of more than 30 years old, skin
The symptoms such as rash color is red the freshest, common dim complexion, pigmentation, spiritlessness and weakness, white and thin fur, and soft pulse is sliding.The above-mentioned traditional Chinese medical science for
Under the theoretical direction of acne and the diagnosis of comedo and treatment, people the most gradually research and develop Chinese medicine composition and reach to treat Cuo
Skin ulcer and the effect of comedo, as Chinese patent CN105955275A discloses a kind of Deacne pack, Chinese medicine ingredients mainly have Flos Carthami,
The Radix Rehmanniae, Fructus Forsythiae and the Radix Linderae, this facial film plays drug effect with natural Chinese medicine ingredients, in order to meet people further for efficiency natural
The demand of product for resolving poxes, carries out the research goed deep into and innovate for the treatment acne of natural Chinese medicine composition and the product of comedo,
Become current problem demanding prompt solution.
Summary of the invention
In order to overcome the defect of prior art, an object of the present invention is that providing a kind of treats in acne whelks
Drug composition, has notable efficient therapeutical effect for polytype acne and comedo.
The two of the purpose of the present invention are to provide a kind of Chinese medicine preparation treating acne whelks.
The three of the purpose of the present invention are to provide a kind of clear paste treating acne whelks.
The four of the purpose of the present invention are to provide the preparation method of a kind of clear paste treating acne whelks.
In order to realize object above, the technical solution adopted in the present invention is:
A kind of Chinese medicine composition treating acne whelks, is made up of the raw material of following parts by weight: Fructus Forsythiae berry extract 2
～4 parts, Herba Taraxaci extract 2～4 parts, Herba Violae extract 2～4 parts, red sage root extract 2～4 parts, Cortex Lycii extract
2～4 parts, Flos Chrysanthemi Indici extract 2～4 parts, licorice root extract 3～5 parts, Radix Bupleuri root extract 3～5 parts, Semen Cassiae extract 3
～5 parts, Radix of Aloe extract 3～5 parts, Folium Mori extract 3～5 parts, Folium Menthae extract 3～5 parts.
The Chinese medicine composition of above-mentioned treatment acne whelks, is made up of the raw material of following weight fraction: Fructus Forsythiae berry extract 3
Part, Herba Taraxaci extract 3 parts, Herba Violae extract 3 parts, red sage root extract 3 parts, Cortex Lycii extract 3 parts, Flos Chrysanthemi Indici carry
Take thing 3 parts, licorice root extract 4 parts, Radix Bupleuri root extract 4 parts, Semen Cassiae extract 4 parts, Radix of Aloe extract 4 parts, Folium Mori
Extract 4 parts, Folium Menthae extract 4 parts.
A kind of Chinese medicine preparation, including Chinese medicine composition, pharmaceutical formulations or the cosmetic formulations of above-mentioned treatment acne whelks
Adjuvant needed for preparation.
A kind of clear paste, including the adjuvant needed for the Chinese medicine composition of above-mentioned treatment acne whelks, clear paste preparation.
Optionally, above-mentioned clear paste is prepared from by the raw material of following parts by weight: above-mentioned treatment acne whelks Chinese drug-treated group
Compound 40～45 parts, glycerol 20～25 parts, carbomer 3～7 parts, PLURONICS F87 3～6 parts, propylene glycol 3～5 parts, hyalomitome
Acid sodium 3～5 parts, sodium hydroxide 0.5～1.5 parts, imidazolidinyl urea 0.5～1.5 parts, methyl hydroxybenzoate 0.2～0.8 part, cocoanut oil alcohol
Polyethers-7 0.1～0.5 parts, PPG-1-PEG-9 Laurel glycol ethers 0.05～0.2 part, Cremophor RH40 0.02～0.1
Part, 2-bromo-2-nitropropane-1,3-glycol 0.05～0.25 part, disodiumedetate 0.05～0.25 part, Rosa centifolia L flower
Oil 0.1～0.3 part, water 310～320 parts.
Preferably, above-mentioned clear paste is prepared from by the raw material of following parts by weight: above-mentioned treatment acne whelks Chinese drug-treated group
Compound 42 parts, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 4.4 parts, propylene glycol 4 parts, hyaluronate sodium 4 parts, hydrogen-oxygen
Change 0.832 part of sodium, imidazolidinyl urea 0.8 part, methyl hydroxybenzoate 0.4 part, coceth-7 0.3 parts, PPG-1-PEG-9 Laurel
Glycol ethers 0.12 part, Cremophor RH40 0.06 part, 2-bromo-2-nitropropane-1,3-glycol 0.16 part, ethylenediamine tetrem
Acid disodium 0.16 part, Rosa centifolia L caul-fat 0.2 part, 315.08 parts of water.
Above-mentioned clear paste treats acne whelks Chinese medicine composition as effective ingredient with the present invention, and add use glycerol, third
Glycol and hyaluronate sodium are compounding as wetting agent, the wetting agent synergism of three kinds of different molecular structures, reduce single moisturizing
The consumption of agent, improves the performance of keeping humidity of clear paste, compares one-component wetting agent and makes the performance of keeping humidity of clear paste of preparation improve 70%,
Being conducive to keeping the activity of Chinese medicine ingredients so that Chinese traditional medicine molecule can permeate with Continuous slow release, wetting agent enters cell through pore
During, the effective ingredient carrying Chinese medicine composition enters cell, promotes the cell Transdermal absorption to Effective Component of Chinese Medicine, holds
Continuous effect, improves clear paste treatment acne and the action and efficacy of comedo；Add and use glycyrrhizic acid dipotassium, collaborative Chinese medicine composition
Each component, plays antibacterial, antiinflammatory, removing toxic substances, effect of antiallergic；Adding use PLURONICS F87 is emulsifying agent, adds cocoanut oil alcohol and gathers
Ether-7, PPG-1-PEG-9 Laurel glycol ethers, Cremophor RH40 are compounding as solubilizing agent, add Carmomer as thickening
Agent, interpolation disodiumedetate, as chelating agen, emulsifying agent and compounding solubilizing agent synergism, improves the matter of clear paste
Structure, promotes more Effective Component of Chinese Medicine to be dissolved into medicine film layer, and drug effect improves 58%, improves skin to effective ingredient saturating in clear paste
Skin absorbent properties, simultaneously compounding solubilizing agent reduces the consumption of single solubilizing agent, reduces single solubilizing agent excessive use to clear paste
The impact of Transdermal absorption performance；Add imidazolidinyl urea, methyl hydroxybenzoate and 2-bromo-2-nitropropane-1,3-glycol and compound conduct
Preservative, extends the shelf life of clear paste, avoids the consumption of single preservative simultaneously, reduce single preservative excessive use to skin
Have side effects；Add and use sodium hydroxide, the flora environment of auxiliary adjustment skin, prevent skin bacterium and fungal infection, with
And the acidic materials infringement to skin of acne whelks secretion, prevent growing of antibacterial and fungus simultaneously, play the work of skin protection
With.
The Chinese medicine composition that above-mentioned clear paste treats acne whelks with the present invention is prepared from for effective ingredient, kills with surface
Take stopgap measures and compare in the compound anti-inflammation and sterilization surface of bacterium, use Chinese medicine ingredients effective ingredient, external, by Cutaneous permeation in follow
Ring, milieu therapy comedo in improving and adjusting, through outer and interior, the combination of inner and outside, treating both the principal and secondary aspects of a disease, safety and effectivity solves acne and green grass or young crops
Spring pox problem is not easy recurrence.
Above-mentioned clear paste is prepared from by the method including following operating procedure:
(1) take part water and add carbomer, after soaking 10～15 hours, carry out homogenizing and be completely dispersed to carbomer, add
Sodium hydroxide, mix homogeneously, obtain mixed material 1, standby；By PLURONICS F87, hyaluronate sodium, 2-bromine 2-nitropropane-1,
3-glycol adds in remaining water, and mix homogeneously obtains mixed material 2, standby；Being added by propylene glycol in methyl hydroxybenzoate, mixing is all
Even, obtain mixed material 3, standby；Take Rosa centifolia L caul-fat and add coceth-7, PPG-1-PEG-9 Laurel glycol ethers, PEG-40
Castor oil hydrogenated, mix homogeneously, obtain mixed material 4；
(2) mixed material 2 is added in mixed material 1, mix homogeneously, obtain mixed material 5；
(3) in mixed material 5, addition Fructus Forsythiae berry extract, Herba Taraxaci extract, Herba Violae extract, red sage root carry
Take thing, Cortex Lycii extract, Flos Chrysanthemi Indici extract, licorice root extract, Radix Bupleuri root extract, Semen Cassiae extract, Radix of Aloe
Extract, Folium Mori extract, Folium Menthae extract, mix homogeneously, obtain mixed material 6；
(4) in mixed material 6, add mixed material 3, mix homogeneously, obtain mixed material 7；Mixed material 7 adds
Mixed material 4, mix homogeneously, obtain described clear paste.
Above-mentioned each Chinese medicine extract is prepared by following methods: put into by raw material of Chinese medicine in Chinese medicine extracting tank, adds 10
The water of times amount, after ebuillition of heated 3 hours, goes out liquid, is filtrated to get Chinese medicine extract, standby.
Active component abbreviated functional description:
Fructus Forsythiae: there is heat clearing away, removing toxic substances, eliminating stagnation, detumescence, antiinflammatory, the effect of resisting pathogenic microbes.Control warm, erysipelas, speckle
Rash, carbuncle and ulcer toxic swelling, scrofula, urine stranguria with urinary obstruction.
Herba Taraxaci: there is heat-clearing and toxic substances removing, diuresis eliminating stagnation, the effect of anti-inflammation.
Herba Violae: taste bitter, acrid, cold, GUIXIN, lung meridian.Having heat-clearing and toxic substances removing, removing heat from blood is subsided a swelling, the effect of clearing away heat-damp and promoting diuresis, main
Control furuncle, carbuncle, scrofula.
Semen Cassiae: there is liver heat removing and eyesight improving, effect of loosening bowel to relieve constipation, it is used for treating the puckery pain of conjunctival congestion, the many tear of photophobia, has a headache dizzy
Dizzy, poor vision, constipation.
Radix of Aloe: for calentura excessive thirst, gastropyretic vomiting, cough due to lung-heat, lung abscess vomiting pus, the puckery pain of pyretic stranguria.Can clear lung stomach
Edema caused by disorder of QI excess-heat, again can promoting the production of body fluid to quench thirst, relieving restlessness, therefore available control consumption of body fluid caused by febrile disease, dysphoria with smothery sensation thirster, also can treat gastric heat and vomit the sound of vomiting, lung-heat
Cough, lung abscess vomiting pus, the puckery pain of pyretic stranguria.
Radix Salviae Miltiorrhizae: have blood circulation promoting and blood stasis dispelling, inducing menstruation to relieve menalgia, clear away heart-fire relieving restlessness, effect of removing heat from blood eliminating carbuncle.For obstruction of qi in the chest and cardialgia, gastral cavity abdomen
Hypochondriac pain, the accumulation of abdominal mass abdominal mass, pyretic arthralgia pain, dysphoria and insomnia, menoxenia, dysmenorrhea amenorrhea, skin infection swells and ache.
Herba Menthae: be pungent cool property sweating antipyretic medicine, controls influenza, headache, conjunctival congestion, fever of the body, throat, dental bed swell and ache
Disease.External can training the mind dysmenorrhoea, skin pruritus, erythra and eczema etc..Usually with Herba Menthae for tea, clear away heart-fire improving eyesight.
Cortex Lycii: there is heat clearing away, effect of removing heat from blood.Control asthenia hectic fever night sweat, lung-heat cough with asthma, spit blood, epistaxis, stranguria with blood, disappear
Yearningly, hypertension, carbuncle, malignant boil.
Folium Mori: there is stronger antiinflammatory action, with dispel the wind, heat clearing away effect is consistent, the scattered wind heat extraction of Folium Mori, liver heat removing and eyesight improving,
The action and efficacy of removing toxic substances, has significant curative effect for treatment acne, brown macules.
Flos Chrysanthemi Indici: bitter in the mouth, pungent, cool, heat-clearing and toxic substances removing, wind-dispelling heat-dissipating, dissipating blood stasis, improving eyesight, blood pressure lowering.Preventing and treating epidemic cerebrospinal
Film is scorching, prevents influenza, flu, treatment hypertension, hepatitis, dysentery, carbuncle furuncle treatment skin ulcer to have positive effect.
Radix Bupleuri: there is reconciling superficies and interior, dispersing the stagnated live-QI to relieve the stagnation of QI, ascending up spleen-Qi and Yang, the effect of preventing the attack (or recurrence) of malaria of bringing down a fever.
Radix Glycyrrhizae: most of gram positive bacterias and gram negative bacteria and partial yeast bacterium are had good Developing restraint
Effect, is used for treating ulcer sores, laryngopharynx swelling and pain etc..Can be alone, for oral administration or external application, or compatibility application.Ulcer sores, Chang Yujin
Flos Lonicerae, Fructus Forsythiae equivalent use, plays the merit of heat-clearing and toxic substances removing, altogether such as Xian fang Huoming Yin.Radix Glycyrrhizae also has antiinflammatory, anti-allergic effects, can protect
The throat of inflammation and tunica mucosa tracheae.Radix Glycyrrhizae extractum and glycyrrhizic acid have the Detoxication of similar glucuronic acid to some poisonous substance.
The guideline of above-mentioned skin lightening whitening Chinese medicament compositions treatment dull-looking skin is: with the lung meridian intrinsic heat of tcm diagnosis
The acne whelks pathogeny of type, heat-toxin type, spleen and stomach damp-heat type, caused by hepatic stagnation qi stagnation wherein type, treats based on dialectical, many
With clearing away lung-heat, heat of dispeling the wind, removing heat from blood and promoting blood circulation, mass dissipating and swelling eliminating, antimicrobial and anti-inflammation efficacy synergism, regulate owing to interior-heat and endocrine are drawn
The skin cell metabolism risen is abnormal, it is to avoid facial acne and the generation of comedo.
The present invention treats the Chinese medicine composition of acne whelks, by Fructus Forsythiae berry extract, Herba Taraxaci extract, Herba Violae
Extract, Radix Salviae Miltiorrhizae extract, Cortex Lycii extract, Flos Chrysanthemi Indici extract, licorice root extract, Radix Bupleuri root extract, Semen Cassiae
Extract, Radix of Aloe extract, Folium Mori extract, Folium Menthae extract form, and each raw material, in the amount ranges limited, is worked in coordination with and made
With, wind and heat eliminating, blood circulation promoting and blood stasis dispelling, dispersing swelling and dissipating binds, regulation of skin cellular metabolism function, regulation of skin sebum secretion, anti-inflammation,
The abnormal flora of suppression grows, and then reaches to treat acne and the curative effect of comedo.Particularly as follows: Radix Bupleuri root extract, Cortex Lycii carry
Take thing, Flos Chrysanthemi Indici extract synergism, play effect of clearing away lung-heat；Radix Glycyrrhizae extract, Folium Mori extract, Folium Menthae extract,
Semen Cassiae extract and Radix of Aloe extract synergism, play the effect of heat of dispeling the wind；Folium Mori extract, Fructus Forsythiae berry extract,
Red sage root extract, Herba Violae extract synergism, play effect of removing heat from blood and promoting blood circulation；Fructus Forsythiae berry extract, Flos Chrysanthemi Indici carry
Take thing, Folium Menthae extract synergism, play the action and efficacy of dispersing swelling and dissipating binds；Radix Glycyrrhizae extract and the collaborative work of Folium Mori extract
With, playing effect of anti-inflammation and sterilization, growing of suppression skin abnormality flora, Radix Glycyrrhizae regulation simultaneously neutralizes each Chinese materia medica tocixity of formula,
Improve the compatibility safety of each raw material.
Detailed description of the invention
Below by specific embodiment, technical scheme is described in detail.
Embodiment 1
A kind of Chinese medicine composition treating acne whelks, is made up of the raw material of following parts by weight: Fructus Forsythiae berry extract 3
Part, Herba Taraxaci extract 3 parts, Herba Violae extract 3 parts, red sage root extract 3 parts, Cortex Lycii extract 3 parts, Flos Chrysanthemi Indici carry
Take thing 3 parts, licorice root extract 4 parts, Radix Bupleuri root extract 4 parts, Semen Cassiae extract 4 parts, Radix of Aloe extract 4 parts, Folium Mori
Extract 4 parts, Folium Menthae extract 4 parts.
The Chinese medicine composition utilizing above-mentioned treatment acne whelks prepares clear paste, by the raw material preparation of following parts by weight
Become: the present embodiment treatment acne whelks Chinese medicine composition 42 parts, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 4.4
Part, propylene glycol 4 parts, hyaluronate sodium 4 parts, sodium hydroxide 0.832 part, imidazolidinyl urea 0.8 part, methyl hydroxybenzoate 0.4 part, cocos nucifera oil
Alcohol polyethers-7 0.3 parts, PPG-1-PEG-9 Laurel glycol ethers 0.12 part, Cremophor RH40 0.06 part, 2-bromo-2-nitro
Propane-1,3-glycol 0.16 part, disodiumedetate 0.16 part, Rosa centifolia L caul-fat 0.2 part, 315.08 parts of water.
The preparation method of the present embodiment clear paste, concrete operation step is:
(1) take part water and add carbomer, after soaking 10～15 hours, carry out homogenizing and be completely dispersed to carbomer, add
Sodium hydroxide, mix homogeneously, obtain mixed material 1, standby；By PLURONICS F87, hyaluronate sodium, 2-bromine 2-nitropropane-1,
3-glycol adds in remaining water, and mix homogeneously obtains mixed material 2, standby；Being added by propylene glycol in methyl hydroxybenzoate, mixing is all
Even, obtain mixed material 3, standby；Take Rosa centifolia L caul-fat and add coceth-7, PPG-1-PEG-9 Laurel glycol ethers, PEG-40
Castor oil hydrogenated, mix homogeneously, obtain mixed material 4；
(2) mixed material 2 is added in mixed material 1, mix homogeneously, obtain mixed material 5；
(3) in mixed material 5, addition Fructus Forsythiae berry extract, Herba Taraxaci extract, Herba Violae extract, red sage root carry
Take thing, Cortex Lycii extract, Flos Chrysanthemi Indici extract, licorice root extract, Radix Bupleuri root extract, Semen Cassiae extract, Radix of Aloe
Extract, Folium Mori extract, Folium Menthae extract, mix homogeneously, obtain mixed material 6；
(4) in mixed material 6, add mixed material 3, mix homogeneously, obtain mixed material 7；Mixed material 7 adds
Mixed material 4, mix homogeneously, obtain described clear paste.
Above-mentioned each Chinese medicine extract is prepared by following methods: put into by raw material of Chinese medicine in Chinese medicine extracting tank, adds 10
The water of times amount, after ebuillition of heated 3 hours, goes out liquid, is filtrated to get Chinese medicine extract, standby.
After testing, the present embodiment prepares the micro-biology experiment of clear paste: total plate count, yeast and mold sum, excrement are big
Intestinal flora, staphylococcus aureus, Pseudomonas aeruginosa meet the requirement of " cosmetics health specification " (version in 2007)；Hygienization
Learn index: hydrargyrum, arsenic, lead content all meet the requirement of " cosmetics health specification " (version in 2007).
Embodiment 2
A kind of Chinese medicine composition treating acne whelks, is made up of the raw material of following parts by weight: Fructus Forsythiae berry extract 2
Part, Herba Taraxaci extract 2 parts, Herba Violae extract 2 parts, red sage root extract 2 parts, Cortex Lycii extract 2 parts, Flos Chrysanthemi Indici carry
Take thing 2 parts, licorice root extract 3 parts, Radix Bupleuri root extract 3 parts, Semen Cassiae extract 3 parts, Radix of Aloe extract 3 parts, Folium Mori
Extract 3 parts, Folium Menthae extract 3 parts.
The Chinese medicine composition utilizing above-mentioned treatment acne whelks prepares clear paste, by the raw material preparation of following parts by weight
Become: the present embodiment treatment acne whelks Chinese medicine composition 40 parts, glycerol 20 parts, carbomer 3 parts, PLURONICS F87 3 parts, third
Glycol 3 parts, hyaluronate sodium 3 parts, sodium hydroxide 0.5 part, imidazolidinyl urea 0.5 part, methyl hydroxybenzoate 0.2 part, coceth-
7 0.1 parts, PPG-1-PEG-9 Laurel glycol ethers 0.05 part, Cremophor RH40 0.02 part, 2-bromo-2-nitropropane-1,
3-glycol 0.05 part, disodiumedetate 0.05 part, Rosa centifolia L caul-fat 0.1 part, 310 parts of water.
The preparation method of the present embodiment clear paste is with embodiment 1.
Embodiment 3
A kind of Chinese medicine composition treating acne whelks, is made up of the raw material of following parts by weight: Fructus Forsythiae berry extract 3
Part, Herba Taraxaci extract 3 parts, Herba Violae extract 3 parts, red sage root extract 3 parts, Cortex Lycii extract 3 parts, Flos Chrysanthemi Indici carry
Take thing 3 parts, licorice root extract 4 parts, Radix Bupleuri root extract 4 parts, Semen Cassiae extract 4 parts, Radix of Aloe extract 4 parts, Folium Mori
Extract 4 parts, Folium Menthae extract 4 parts.
The Chinese medicine composition utilizing above-mentioned treatment acne whelks prepares clear paste, by the raw material preparation of following parts by weight
Become: the present embodiment treatment acne whelks Chinese medicine composition 45 parts, glycerol 25 parts, carbomer 7 parts, PLURONICS F87 6 parts, third
Glycol 5 parts, hyaluronate sodium 5 parts, sodium hydroxide 1.5 parts, imidazolidinyl urea 1.5 parts, methyl hydroxybenzoate 0.8 part, coceth-
7 0.5 parts, PPG-1-PEG-9 Laurel glycol ethers 0.2 part, Cremophor RH40 0.1 part, 2-bromo-2-nitropropane-1,3-
Glycol 0.25 part, disodiumedetate 0.25 part, Rosa centifolia L caul-fat 0.3 part, 320 parts of water.
The preparation method of the present embodiment clear paste is with embodiment 1.
Clinical effectiveness is tested:
Patient data: patient all showed as skin of face and had obvious acne whelks 14～36 years old the age.
Therapeutic Method: the clear paste of the application embodiment of the present invention 1 preparation.Specifically used method, after clean water skin, takes
Appropriate this product clear paste, directly spreads upon at small pox, and every day can repeatedly use in (2-5 time).
Therapeutic effect is added up, as shown in table 1 below:
Administration time with statistical effect is: medication 3～4 days, and the facial comedo of 60% patient eliminates positive effect；With
Medicine 7～10 days, the facial comedo of 72% patient understands there is good result；Medication 15 days, the facial comedo of 88% patient disappears
Except there being good result；Medication 28 days, the facial comedo of 95% patient eliminates positive effect.
According to statistics, 85% patient nothing recurrence in curing 1 year.
Claims (7)
1. the Chinese medicine composition treating acne whelks, it is characterised in that be made up of the raw material of following parts by weight: Fructus Forsythiae
Berry extract 2～4 parts, Herba Taraxaci extract 2～4 parts, Herba Violae extract 2～4 parts, red sage root extract 2～4 parts,
Cortex Lycii extract 2～4 parts, Flos Chrysanthemi Indici extract 2～4 parts, licorice root extract 3～5 parts, Radix Bupleuri root extract 3～5 parts, certainly
Pine torch extract 3～5 parts, Radix of Aloe extract 3～5 parts, Folium Mori extract 3～5 parts, Folium Menthae extract 3～5 parts.
2. the Chinese medicine composition treating acne whelks as claimed in claim 1, it is characterised in that by following weight fraction
Raw material form: Fructus Forsythiae berry extract 3 parts, Herba Taraxaci extract 3 parts, Herba Violae extract 3 parts, red sage root extract 3 parts,
Cortex Lycii extract 3 parts, Flos Chrysanthemi Indici extract 3 parts, licorice root extract 4 parts, Radix Bupleuri root extract 4 parts, Semen Cassiae extract 4
Part, Radix of Aloe extract 4 parts, Folium Mori extract 4 parts, Folium Menthae extract 4 parts.
3. a Chinese medicine preparation, it is characterised in that include the Chinese drug-treated group treating acne whelks as claimed in claim 1 or 2
Adjuvant needed for compound, pharmaceutical formulations or cosmetic formulations preparation.
4. a clear paste, it is characterised in that include treating as claimed in claim 1 or 2 the Chinese medicine composition of acne whelks, clear
Adjuvant needed for cream preparation.
5. clear paste as claimed in claim 4, it is characterised in that be prepared from by the raw material of following parts by weight: as right is wanted
Ask the treatment acne whelks Chinese medicine composition 40 described in 1 or 2～45 parts, glycerol 20～25 parts, carbomer 3～7 parts, Bo Luosha
Nurse 188 3～6 parts, propylene glycol 3～5 parts, hyaluronate sodium 3～5 parts, sodium hydroxide 0.5～1.5 parts, imidazolidinyl urea 0.5～
1.5 parts, methyl hydroxybenzoate 0.2～0.8 part, coceth-7 0.1～0.5 parts, PPG-1-PEG-9 Laurel glycol ethers 0.05～
0.2 part, Cremophor RH40 0.02～0.1 part, 2-bromo-2-nitropropane-1,3-glycol 0.05～0.25 part, ethylenediamine
Tetraacethyl disodium 0.05～0.25 part, Rosa centifolia L caul-fat 0.1～0.3 part, water 310～320 parts.
6. clear paste as claimed in claim 5, it is characterised in that be prepared from by the raw material of following parts by weight: as right is wanted
Ask the treatment acne whelks Chinese medicine composition 42 parts described in 1 or 2, glycerol 22 parts, carbomer 5.2 parts, PLURONICS F87 4.4
Part, propylene glycol 4 parts, hyaluronate sodium 4 parts, sodium hydroxide 0.832 part, imidazolidinyl urea 0.8 part, methyl hydroxybenzoate 0.4 part, cocos nucifera oil
Alcohol polyethers-7 0.3 parts, PPG-1-PEG-9 Laurel glycol ethers 0.12 part, Cremophor RH40 0.06 part, 2-bromo-2-nitro
Propane-1,3-glycol 0.16 part, disodiumedetate 0.16 part, Rosa centifolia L caul-fat 0.2 part, 315.08 parts of water.
7. the preparation method of the clear paste as described in claim 5 or 6, it is characterised in that include following operating procedure:
(1) take part water and add carbomer, after soaking 10～15 hours, carry out homogenizing and be completely dispersed to carbomer, add hydrogen-oxygen
Change sodium, mix homogeneously, obtain mixed material 1, standby；By PLURONICS F87, hyaluronate sodium, 2-bromine 2-nitropropane-1,3-two
Alcohol adds in remaining water, and mix homogeneously obtains mixed material 2, standby；Propylene glycol is added in methyl hydroxybenzoate, mix homogeneously,
Mixed material 3, standby；Take Rosa centifolia L caul-fat and add coceth-7, PPG-1-PEG-9 Laurel glycol ethers, PEG-40 hydrogenation
Oleum Ricini, mix homogeneously, obtain mixed material 4；
(2) mixed material 2 is added in mixed material 1, mix homogeneously, obtain mixed material 5；
(3) in mixed material 5, add Fructus Forsythiae berry extract, Herba Taraxaci extract, Herba Violae extract, red sage root extraction
Thing, Cortex Lycii extract, Flos Chrysanthemi Indici extract, licorice root extract, Radix Bupleuri root extract, Semen Cassiae extract, Radix of Aloe carry
Take thing, Folium Mori extract, Folium Menthae extract, mix homogeneously, obtain mixed material 6；
(4) in mixed material 6, add mixed material 3, mix homogeneously, obtain mixed material 7；Mixing is added in mixed material 7
Material 4, mix homogeneously, obtain described clear paste.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929116A (en) * | 2016-10-13 | 2018-04-20 | 高丽雅娜化妆品股份有限公司 | The cosmetic combination for being used to mitigate acne comprising cassia seed extract |
| CN108553356A (en) * | 2018-05-17 | 2018-09-21 | 广州兰若坊生物科技有限公司 | A kind of compound Chinese herb toxin expelling anti-acne essence composition |
| CN113018326A (en) * | 2021-03-18 | 2021-06-25 | 中国药科大学 | Acne-removing traditional Chinese medicine emulsifiable paste for regulating skin micro-ecological structure and preparation method thereof |
| CN116077388A (en) * | 2022-11-29 | 2023-05-09 | 山东禾宝药业有限公司 | Acne-removing Chinese herbal medicine composition and preparation method and application thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259172A (en) * | 2007-03-06 | 2008-09-10 | 上海家化联合股份有限公司 | Chinese medicinal composition for treating acne, preparation and application thereof |
| CN102274159A (en) * | 2011-07-12 | 2011-12-14 | 广东东阳光药业有限公司 | Retinoic acid medicinal composition for skin permeation administration and preparation method of retinoic acid medicinal composition |
-
2016
- 2016-07-20 CN CN201610577262.3A patent/CN106038873A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101259172A (en) * | 2007-03-06 | 2008-09-10 | 上海家化联合股份有限公司 | Chinese medicinal composition for treating acne, preparation and application thereof |
| CN102274159A (en) * | 2011-07-12 | 2011-12-14 | 广东东阳光药业有限公司 | Retinoic acid medicinal composition for skin permeation administration and preparation method of retinoic acid medicinal composition |
Non-Patent Citations (1)
| Title |
|---|
| 顾严严: ""中医美容方剂的配伍规律研究——治疗痤疮、黄褐斑及抗皮肤衰老方剂的配伍规律研究"", 《中国优秀硕士学位论文全文数据库医药卫生科技辑》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107929116A (en) * | 2016-10-13 | 2018-04-20 | 高丽雅娜化妆品股份有限公司 | The cosmetic combination for being used to mitigate acne comprising cassia seed extract |
| CN108553356A (en) * | 2018-05-17 | 2018-09-21 | 广州兰若坊生物科技有限公司 | A kind of compound Chinese herb toxin expelling anti-acne essence composition |
| CN113018326A (en) * | 2021-03-18 | 2021-06-25 | 中国药科大学 | Acne-removing traditional Chinese medicine emulsifiable paste for regulating skin micro-ecological structure and preparation method thereof |
| CN116077388A (en) * | 2022-11-29 | 2023-05-09 | 山东禾宝药业有限公司 | Acne-removing Chinese herbal medicine composition and preparation method and application thereof |
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Effective date of registration: 20180614 Address after: 271100 16 town of medicine Town, Laicheng District, Laiwu, Shandong Applicant after: Shandong Wo Bao Pharmaceutical Co., Ltd. Address before: 100102 Beijing Chaoyang District Wangjing Street 9 Commercial Building 1 floor 1200 Applicant before: Beijing kangshengyuan Thai Technology Co. Ltd. |
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