CN106038913B - A kind of Chinese medicine composition that treating Gynecological cervical inflammation and its application - Google Patents
A kind of Chinese medicine composition that treating Gynecological cervical inflammation and its application Download PDFInfo
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Abstract
The present invention relates to a kind of Chinese medicine composition for treating Gynecological cervical inflammation, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight: 20-40 parts of airpotato yam, 20-40 parts of Lappula echinata, 1-5 parts of Radix Notoginseng.The present invention also provides application of the above-mentioned Chinese medicine composition in preparation treatment cervicitis medicine.Chinese medicine composition flavour of a drug number of the invention is few, and abundant raw materials, preparation process is simple, environmentally friendly, there is good application prospect in cervicitis.Airpotato yam, Lappula echinata and the Radix Notoginseng that the present invention treats in uterine neck composition have obvious synergistic effect.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, specifically, be a kind of Chinese medicine composition for treating Gynecological cervical inflammation and its
Using.
Background technique
Cervicitis is one of gynaecology's common disease.Under normal circumstances uterine neck have a variety of defense functions, but uterine neck vulnerable to
Childbirth, the damage of uteroventral operation, and the column upper layer thin skin of neck tube, it is vulnerable, it is easily invaded by pathogen and causes inflammation.
Common in clinic is acute and chronic cervicitis, and acute cervicitis major part patient is asymptomatic.There is symptom mainly to show
Increase for vaginal fluid, be in mucus purulence, guidance secretion stimulation can cause pruritus vulvue and burning heat sensation.In addition, may occur in which
The symptoms such as intermenstrual bleeding, postcoital bleeding.If merging urinary tract infections, urgent urination, frequent micturition, urodynia may occur in which.If stranguria syndrome Neisser
Bacterium infection, because paraurethral gland, greater vestibular gland are involved, it is seen that urethral orifice, the hyperemia of introitus mucous membrane, oedema and volume purulent secretion
Object.If acute cervicitis persistently exists without timely diagnosis and treatment or pathogen, chronic cervicitis disease can lead to.Chronic cervicitis
How asymptomatic patient is also, and small number of patients can have vaginal fluid to increase, faint yellow or purulence, postcoital bleeding, and intermenstrual period goes out
Blood occasionally has secretion stimulation to cause pruritus vulvue uncomfortable.Gynecologial examination can find that cervix is in that rotten to the corn sample changes, or has yellow point
Secretion covers cervical orifice or flows out from cervical orifice, can also appear as cervical polyp or cervix is loose.
Prior art discloses a variety of for treating the Chinese medicine of cervicitis, as Chinese patent 2016100453053 discloses
A kind of Chinese medicine for treating chronic cervicitis, raw material include frutus cnidii, smilax, the fruit of summer cypress, purslane, field pennycress, the heart of a lotus seed
The seed of jog's tears, viola mandshurica, hairyvein agrimony, dandelion, rhizoma alismatis, kuh-seng, alum, realgar, the coptis, Cortex Phellodendri, rhizoma atractylodis, Radix Angelicae Sinensis, radix paeoniae rubra, tree peony
Skin, Radix Salviae Miltiorrhizae, rhizoma corydalis, dried orange peel, rhizoma pinellinae praeparata, raw Rhizoma Atractylodis Macrocephalae and licorice, have clear curative effect, and under clinical use dosage absolutely
Safety.Chinese patent 2015109658529 discloses a kind of for treating the external preparation of Gynecological cervical inflammation, and following weight is taken to match
The primary raw material medicine of ratio is prepared: cockscomb 8-13, cymose buckwheat rhizome 6-12, Common Sage Herb 9-13, Artemisia capillaris 5-10, cacumen biotae 3-9,
Root of Twelve stamen Melastoma 7-13, purulence are shown in anxious 4-9, radix semiaquilegiae 2-8, herba sedi multicaulis 5-11, asiatic striga herb 7-12, orangeeye butterflybush branchlet and leaf or root-bark 4-10, tree of heaven ailanthus bark 6-11, chicken
Sincere grass 8-12, lanatechead saussurea herb with flower 5-9, Sri Lanka Pouzolzia Herb 3-8, the Chinese medicine composition go directly affected area, and quick result, the course for the treatment of is shorter, treatment cost
It with lower, does not perform the operation, hurtless measure, safe, without side-effects, curative for effect, significant effect, cure rate is high, uneasy to recur.But this
A little drugs still have the disadvantage that flavour of a drug are more, therapeutic effect is not good enough.Therefore, need that a kind of flavour of a drug number is less, raw material are easy to get, make
Standby simple process and the apparent drug of therapeutic effect, and had not been reported at present about this kind of drug.
Summary of the invention
The purpose of the present invention is aiming at the shortcomings in the prior art, provide a kind of Chinese traditional medicine composition for treating Gynecological cervical inflammation
Object.
Another purpose of the invention is to provide the purposes of Chinese medicine composition as described above.
Another purpose of the invention is to provide a kind of external drug prevented and/or treat cervicitis.
To achieve the above object, the technical solution adopted by the present invention is that:
A kind of Chinese medicine composition for treating Gynecological cervical inflammation, the Chinese medicine composition by following parts by weight bulk pharmaceutical chemicals system
At: 20-40 parts of airpotato yam, 20-40 parts of Lappula echinata, 1-5 parts of Radix Notoginseng.
Preferably, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight: 25-35 parts of airpotato yam, Lappula echinata 25-35
Part, 2-4 parts of Radix Notoginseng.
Preferably, the Chinese medicine composition is made of the bulk pharmaceutical chemicals of following parts by weight: 30 parts of airpotato yam, 30 parts of Lappula echinata, three
73 parts.
To realize above-mentioned second purpose, the technical solution adopted by the present invention is that:
Application of any Chinese medicine composition as above in the drug of preparation prevention and/or treatment cervicitis.
The cervicitis is acute cervicitis or chronic cervicitis.
Pharmaceutically acceptable carrier can be added as needed and be prepared into any pharmaceutical dosage form for the drug.
The drug further includes the auxiliary material pharmaceutically allowed.
To realize above-mentioned third purpose, the technical solution adopted by the present invention is that:
It is a kind of prevention and/or treatment cervicitis external drug, the drug the preparation method is as follows:
1) parts by weight weigh Chinese medicine material as described above, add 30 times of boiling water water to mention 3h for the first time, add for the second time
20 times of boiling water water mentions 2h, filtering, merging filtrate, and it is 1.08-1.10g/cm that filtrate is condensed into density under 60 DEG C of environment3It is dense
Contracting liquid；
2) beeswax and vaseline are taken, heating water bath adds olive oil to melting, mixes；Separately take lanolin, heating water bath is to molten
Change, the concentrate of step 1) preparation is added, is sufficiently mixed, is mixed while hot with the mixture of beeswax, vaseline and olive oil, it is slightly cold
But peppermint oil is added dropwise afterwards, mixes well, sets in vacuum oven, is kept for 25 DEG C, is taken out after depressurizing de-bubbled, it is filling；Institute
It states every part of Chinese medicine and corresponds to beeswax 0.5g, vaseline 5g, olive oil 1ml, lanolin 0.2g.
It is a kind of prevention and/or treatment cervicitis external drug, the drug the preparation method is as follows:
1) raw material is weighed according to parts by weight described in claim 1-3, adds 30 times of boiling water water to mention 3h for the first time, second
Add 20 times of boiling water water to mention 2h, filter, merging filtrate, it is 1.08-1.10g/cm that filtrate is condensed into density under 60 DEG C of environment3's
Concentrate；
2) press overall weight percent 100%, remove ionized water 80%, xanthan gum 0.5%, propylene glycol 5%, concentrate 4%,
Beeswax 5% and vaseline 5.5% add mentioned component when 55 DEG C in order, mix.
The invention has the advantages that:
1, the advantages such as drug of the invention is made of pure Chinese medicine, has and has no toxic side effect, and price is low.
2, drug flavour of a drug number of the invention is few, and abundant raw materials, preparation process is simple, environmentally friendly, slow in treatment
There is good application prospect in property cervicitis.
3, xanthate, Lappula echinata and the Radix Notoginseng in present invention treatment uterine neck composition have obvious synergistic effect.
4, the proportion of the traditional chinese medicine composition of the invention is to screen to obtain by many experiments, with good effect, short treating period
Advantage.
Specific embodiment
The invention will be further elucidated with reference to specific embodiments.It should be understood that these embodiments are merely to illustrate this hair
It is bright rather than limit the scope of the invention.In addition, it should also be understood that, after having read the content of the invention recorded, art technology
Personnel can make various changes or modifications the present invention, and such equivalent forms equally fall within the application the appended claims and limited
Fixed range.
The Chinese medicine composition (one) of the treatment cervicitis of embodiment 1
30 parts of airpotato yam, 30 parts of Lappula echinata, 3 parts of Radix Notoginseng.
The Chinese medicine composition (two) of the treatment cervicitis of embodiment 2
20 parts of airpotato yam, 20 parts of Lappula echinata, 1 part of Radix Notoginseng.
The Chinese medicine composition (three) of the treatment cervicitis of embodiment 3
40 parts of airpotato yam, 20 parts of Lappula echinata, 1 part of Radix Notoginseng.
The Chinese medicine composition (four) of the treatment cervicitis of embodiment 4
40 parts of airpotato yam, 40 parts of Lappula echinata, 1 part of Radix Notoginseng.
The Chinese medicine composition (five) of the treatment cervicitis of embodiment 5
40 parts of airpotato yam, 40 parts of Lappula echinata, 5 parts of Radix Notoginseng.
The Chinese medicine composition (six) of the treatment cervicitis of embodiment 6
25 parts of airpotato yam, 25 parts of Lappula echinata, 2 parts of Radix Notoginseng.
The Chinese medicine composition (seven) of the treatment cervicitis of embodiment 7
35 parts of airpotato yam, 25 parts of Lappula echinata, 2 parts of Radix Notoginseng.
The Chinese medicine composition (eight) of the treatment cervicitis of embodiment 8
35 parts of airpotato yam, 35 parts of Lappula echinata, 2 parts of Radix Notoginseng.
The Chinese medicine composition (nine) of the treatment cervicitis of embodiment 9
35 parts of airpotato yam, 35 parts of Lappula echinata, 4 parts of Radix Notoginseng.
The Chinese medicine composition (ten) of the treatment cervicitis of embodiment 10
28 parts of airpotato yam, 32 parts of Lappula echinata, 4 parts of Radix Notoginseng.
The Chinese medicine composition (11) of the treatment cervicitis of embodiment 11
325 parts of airpotato yam, 28 parts of Lappula echinata, 2 parts of Radix Notoginseng.
The Chinese medicine composition (12) of the treatment cervicitis of embodiment 12
34 parts of airpotato yam, 26 parts of Lappula echinata, 3 parts of Radix Notoginseng.
The Chinese medicine composition (13) of the treatment cervicitis of embodiment 13
31 parts of airpotato yam, 26 parts of Lappula echinata, 4 parts of Radix Notoginseng.
The preparation (one) of the external drug of the prevention of embodiment 14 and/or treatment cervicitis
1) Chinese medicine material is weighed according to parts by weight described in embodiment 1-13, adds 30 times of boiling water water to mention 3h for the first time, the
Secondary plus 20 times boiling water water mention 2h, filter, merging filtrate, and it is 1.08-1.10g/ that filtrate is condensed into density under 60 DEG C of environment
cm3Concentrate；
2) beeswax and vaseline are taken, heating water bath adds olive oil to melting, mixes；Separately take lanolin, heating water bath is to molten
Change, the concentrate of step 1) preparation is added, is sufficiently mixed, is mixed while hot with the mixture of beeswax, vaseline and olive oil, it is slightly cold
But peppermint oil is added dropwise afterwards, mixes well, sets in vacuum oven, is kept for 25 DEG C, is taken out after depressurizing de-bubbled, it is filling；Institute
It states every part of Chinese medicine and corresponds to beeswax 0.5g, vaseline 5g, olive oil 1ml, lanolin 0.2g.
The preparation (two) of the external drug of the prevention of embodiment 15 and/or treatment cervicitis
1) raw material is weighed according to parts by weight described in embodiment 1-13, adds 30 times of boiling water water to mention 3h for the first time, second
Add 20 times of boiling water water to mention 2h, filter, merging filtrate, it is 1.08-1.10g/cm that filtrate is condensed into density under 60 DEG C of environment3's
Concentrate；
2) press overall weight percent 100%, remove ionized water 80%, xanthan gum 0.5%, propylene glycol 5%, concentrate 4%,
Beeswax 5% and vaseline 5.5% add mentioned component when 55 DEG C in order, mix.
The clinical trial of the treatment chronic cervicitis of embodiment 16
One, data and method
1 subjects
120 are that the court's Out-patient Clinic of Department of Gynecology is gone to a doctor different degrees of samples from Patients with Chronic Cervicitis, and the age 20-45 years old.All trouble
Person's uterine neck anti-cancer smear is feminine gender, excludes whole body important organ and blood coagulation disorders, excludes genital tract acute inflammation, and 3 months
Do not receive the treatment of other drugs and physical method inside, and is willing to receive follow-up on schedule.
2 diagnostic criteria
2.1 Western medicine diagnostic criteria
(1) three types are divided into according to degree of inflammation.Simple form: inflammation initial stage, rotten to the corn face are covered by simple columnar epithelium, table
Face is flat；Granular pattern: due to cervix gland epithelium hyperplasia, rotten to the corn face is uneven, is in granular form；Mastoid process type: galandular epithelium
And interstitial proliferation is obvious, surface irregularity is more significant, forms papillary protrusion.
(2) it is divided into three degree according to rotten to the corn area.Slight rotten to the corn: cervical erosion face accounts for uterine neck area less than 1/3；Moderate is rotten
Rotten: cervical erosion face accounts for the 1/3-2/3 of uterine neck area；Severe is rotten to the corn: cervical erosion face is more than uterine neck area 2/3.
2.2 tcm diagnosis standard
Referring to " new Chinese medicine treats cervical erosion guideline of clinical investigations ".
(1) deficiency of spleen and stomach, profuse leukorrhea, Se Bai or yellowish, matter is thin, and continuous continuous, odorless is tired, complexion
Few China or puffiness of the face and limbs, aversion to cold and cold limbs, underbelly pendant pain, soreness and weakness of waist and knees receive few just pool, and frequent urination is long clearly, pale tongue, white,slippery and moist fur,
Deep-slow pulse sinks weak.
(2) leukorrhagia with hepatic stagnation amount is more, and color is yellow, and matter is sticky, tasteful smelly, it is dripping not to the utmost or pruritus vulvae or the puckery pain of urine leaching,
Bitter taste in the mouth and dry throat, red tongue body, tongue fur is yellow, and slippery or string are sliding.
(3) syndrome of accumulated dampness-heat is shown in profuse leukorrhea, and color Huang or red white phase are simultaneous, and matter is sticky, gas dirty smelly, takes off bored deficiency of food, defecates
Viscous not well, scanty drak urine, tongue is red, yellow and greasy fur, slippery and rapid pulse.
3 are included in and exclusion criteria
3.1 are included in standard
(1) meet Western medicine diagnostic criteria.
(2) meet Standards of Chinese Medical Syndrome Differentiation.
(3) age is between 20-50 years old, and the non-menopausal women of sexual intercourse history.
3.2 exclusion criteria
(1) cervical carcinoma and precancerous lesion, by trichomonad, mould, gonococcus, tubercle bacillus, virogenetic inflammation.
(2) age is in under-18s or 50 years old or more person, gestation or breast feeding women, those who are allergic to this drug.
(3) the severe primaries disease such as angiocarpy, liver, kidney and hemopoietic system, mental patient are associated with.
4 treatment methods
Patient is randomly divided into totally four groups for the treatment of group and control group, every group of patient cases' general information no statistical difference meaning
Justice is comparable (P > 0.05).
Treatment group is prepared into external application according to the method for embodiment 14 using the Chinese medicine composition of parts by weight described in embodiment 1
Drug.In sleeping preceding washing vagina daily, is sterilized twice of vagina uterine neck with Iodophor cotton swab, used after cleaning out vagina cervical secretions
Sterile dry cotton swab dries cervical surface, and the thin cotton swab for being soaked with drug is inserted into cervical canal, is taken out after rotating several weeks.Once a day,
Statistical result after three weeks is used continuously.
One group of Chinese medicine composition for using following weight parts: 30 parts of Lappula echinata, 3 parts of Radix Notoginseng is compareed, according to the side of embodiment 14
Method is prepared into external drug.In sleeping preceding washing vagina daily, is sterilized twice of vagina uterine neck with Iodophor cotton swab, clean out vagina palace
Cervical surface is dried with sterile dry cotton swab after neck secretion, the thin cotton swab for being soaked with drug is inserted into cervical canal, is taken after rotating several weeks
Out.Once a day, statistical result after three weeks is used continuously.
Two groups of Chinese medicine compositions for using following weight parts: 30 parts of airpotato yam, 3 parts of Radix Notoginseng are compareed, according to embodiment 14
Method is prepared into external drug.In sleeping preceding washing vagina daily, is sterilized twice of vagina uterine neck with Iodophor cotton swab, clean out vagina
Cervical surface is dried with sterile dry cotton swab after cervical secretions, the thin cotton swab for being soaked with drug is inserted into cervical canal, after rotating several weeks
It takes out.Once a day, statistical result after three weeks is used continuously.
Three groups of Chinese medicine compositions for using following weight parts: 50 parts of airpotato yam, 10 parts of Lappula echinata, 1 part of Radix Notoginseng are compareed, according to reality
The method for applying example 14 is prepared into external drug.It in sleeping preceding washing vagina daily, is sterilized twice of vagina uterine neck with Iodophor cotton swab, cleaning
Cervical surface is dried with sterile dry cotton swab after clean vagina cervical secretions, the thin cotton swab for being soaked with drug is inserted into cervical canal, is turned
It is taken out after dynamic several weeks.Once a day, statistical result after three weeks is used continuously.
5 curative effect determinate standards
Cure: original symptom completely disappears, and cervix is smooth, and rotten to the corn area disappears；
Effective: original symptom completely disappears or substantially reduced, and rotten to the corn reduction of area is small and is greater than the 1/2 of uterine neck；
It is effective: to have the mitigation of symptom's symptom；
Invalid: erosion area and symptom are unchanged before and after treatment.
6 treatment results
6.1 curative effects compare
Treatment group's efficacy result is as follows: 26 (72.2%) is cured, it is effective 9 (25.0%), and it is invalid 1 (2.7%), always
Effective percentage 97.2%.
It is as follows to compare one group of efficacy result: curing 6 (23.0%), it is effective 13 (50.0%), invalid 7
(26.9%), total effective rate 73.0%.
It is as follows to compare two groups of efficacy results: curing 8 (30.8%), it is effective 12 (46.2%), invalid 6
(23.1%), total effective rate 76.9%.
It is as follows to compare three groups of efficacy results: curing 18 (56.3%), it is effective 13 (40.6%), invalid 1
(3.1%), total effective rate 96.9%.
Compared with control group cure rate, treatment group is apparently higher than control group (P < 0.05) for treatment group.
1 four groups of patient's curative effects of table compare
| Group | n | It cures | Effectively | In vain | Total effective rate |
| Treatment group | 36 | 26 | 9 | 1 | 35 (97.2%) |
| Compare one group | 26 | 6* | 13 | 7 | 19 (73.0%) * |
| Compare two groups | 26 | 8* | 12 | 6 | 20 (76.9%) * |
| Compare three groups | 32 | 18* | 13 | 1 | 31 (96.9%) |
Note: P < 0.05 * compared with treatment group.
The 6.2 clinical symptoms improvement time compares
Treatment group's neoplasm, urinary tract infection, lower abdomen pendant pain, waist and sacrum pain symptom improve the time be respectively (0.50 ±
0.15) day, (4.75 ± 1.65) day, (4.60 ± 1.30) day, (2.65 ± 1.35) day, compared with the control group P < 0.05, difference
With conspicuousness, illustrate treatment group's curative effect better than control group.Treatment group's healing of cervical erosion time is (3.15 ± 0.50) week, is controlled
The treatment group healing of cervical erosion time is considerably shorter than control group (P < 0.05).
2 four groups of patient clinical symptoms improvement times of table compare
Note: P < 0.05 * compared with treatment group.
Vital sign is steady and without the serious adverse reactions such as allergy, treatment end over the course for the treatment of by all patients for the treatment of group
The obvious abnormal response such as allergy is had no to treatment group follow-up of patients afterwards, shows that the clinical application of we is safely and effectively, to be worth
It further studies and promotes and applies.
The above is only a preferred embodiment of the present invention, it is noted that for the ordinary skill people of the art
Member, under the premise of not departing from the method for the present invention, can also make several improvement and supplement, these are improved and supplement also should be regarded as
Protection scope of the present invention.
Claims (4)
1. a kind of external medicine composition for treating gynecologic chronic cervicitis, which is characterized in that the Chinese medicine composition is by following
The bulk pharmaceutical chemicals of parts by weight are made: 30 parts of airpotato yam, 30 parts of Lappula echinata, 3 parts of Radix Notoginseng；The preparation method is as follows:
1) raw material is weighed according to parts by weight, adds 30 times of boiling water water to mention 3h for the first time, second plus 20 times of boiling water water proposes 2h, mistake
Filter, merging filtrate, it is 1.08-1.10g/cm that filtrate is condensed into density under 60 DEG C of environment3Concentrate；
2) overall weight percent 100% is pressed, ionized water 80%, xanthan gum 0.5%, propylene glycol 5%, concentrate 4%, 5% and of beeswax are removed
Vaseline 5.5% adds mentioned component when 55 DEG C in order, mixes.
2. application of the Chinese medicine composition described in claim 1 in the external drug of preparation treatment chronic cervicitis.
3. application according to claim 2, which is characterized in that it is acceptable that drug is added in the external drug as needed
Carrier be prepared into any pharmaceutical dosage form.
4. application according to claim 2, which is characterized in that the external drug further include pharmaceutically allow it is auxiliary
Material.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610478904.4A CN106038913B (en) | 2016-06-27 | 2016-06-27 | A kind of Chinese medicine composition that treating Gynecological cervical inflammation and its application |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610478904.4A CN106038913B (en) | 2016-06-27 | 2016-06-27 | A kind of Chinese medicine composition that treating Gynecological cervical inflammation and its application |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302634A (en) * | 2000-07-28 | 2001-07-11 | 周培基 | Medicine for curing metritis |
| CN1682773A (en) * | 2004-04-13 | 2005-10-19 | 柴薇 | Compound preparation for treating cervicitis |
| CN103800761A (en) * | 2014-03-18 | 2014-05-21 | 黄淑娟 | Traditional Chinese medicine composition for treating cervicitis |
| CN104857096A (en) * | 2015-05-26 | 2015-08-26 | 陈爱华 | Traditional Chinese medicine composition for treating cervicitis |
| CN105412244A (en) * | 2015-12-30 | 2016-03-23 | 李万青 | Traditional Chinese medicine composition treating gynecological cervicitis |
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1302634A (en) * | 2000-07-28 | 2001-07-11 | 周培基 | Medicine for curing metritis |
| CN1682773A (en) * | 2004-04-13 | 2005-10-19 | 柴薇 | Compound preparation for treating cervicitis |
| CN103800761A (en) * | 2014-03-18 | 2014-05-21 | 黄淑娟 | Traditional Chinese medicine composition for treating cervicitis |
| CN104857096A (en) * | 2015-05-26 | 2015-08-26 | 陈爱华 | Traditional Chinese medicine composition for treating cervicitis |
| CN105412244A (en) * | 2015-12-30 | 2016-03-23 | 李万青 | Traditional Chinese medicine composition treating gynecological cervicitis |
Non-Patent Citations (1)
| Title |
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| 黄药子酒治疗宫颈炎53例疗效;陈远碧;《重庆医药》;19881231;第17卷(第3期);第20页 * |
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