KR101655342B1 - Composition for the treatment and improvement of atopic dermatitis - Google Patents

Abstract

The present invention relates to a composition for treating and improving atopic dermatitis, which comprises an extract of primrose mineral water, Rhodiola extract and green mud as an active ingredient.
The present invention also relates to a cosmetic composition comprising the composition. The composition of the present invention has an effect of treating and ameliorating atopic dermatitis by inhibiting itching and inflammation induction, alleviating skin allergy, and anticipating a whitening effect.

Description

Technical Field [0001] The present invention relates to a composition for treating and improving atopic dermatitis,

The present invention relates to a composition for treating and improving atopic dermatitis containing at least one mineral water, and more particularly, to a composition for treating and improving atopic dermatitis containing primary mineral water, Rhodiola extract, and green mud to inhibit itching and inflammation To alleviate skin allergy, and to expect a whitening effect, and to a method for producing a composition for treating and improving atopic dermatitis.

Atopy is a type of hypersensitivity that has recently become increasingly prevalent as its prevalence increases rapidly. In terms of immunology, immunoglobulin E (E) and allergin It is defined as a group of allergic diseases with genetic tendency with major symptoms.

In particular, atopic dermatitis, a representative symptom of atopy, accounts for 0.5 to 1% of the total population and 5 to 10% of the children have serious symptoms, but it is presumed to be related to genetic factors and immune system deficiency The exact cause of the disease has yet to be clarified, and it is expected that it will be alleviated somewhat through the improvement of environment and diet, but there is no fundamental treatment method.

However, although atopic dermatitis shows individual differences, most of them involve extreme itching, skin dryness, rashes, dirt, scabs, scaly skin (arthropods), and the resulting emotional anxiety, stress, Along with feelings of anger, other allergic diseases such as urticaria, metal allergies, asthma and allergic rhinitis, it is becoming a serious social problem that threatens the public health today.

Meanwhile, representative drugs known to be effective for atopic dermatitis so far include steroids, antihistamines, antibiotics, non-steroids, and other sedatives and nerve stabilizers.

Among them, steroids have excellent effects on anti-inflammation and immunosuppression, but when the skin is used for a long time, the elasticity of the skin disappears and becomes thin, and the vaginal opening becomes unstable. In severe cases, systemic symptoms due to hormones, adrenal dysfunction, And the symptom is deteriorated exponentially when the medicine is stopped.

In addition, antihistamines are only temporary measures to alleviate the itch symptoms by inhibiting histamine from being liberated from mast cells, and side effects such as insomnia, anxiety and loss of appetite appear when used for a long time.

In addition, antibiotics are intended to prevent secondary bacterial infections caused by scratching, rather than as a fundamental therapeutic drug for atopic dermatitis. The use of antibiotics increases resistance and gastrointestinal function, Aplastic anemia due to bone marrow function, and the like.

In addition, other non-steroids are only a moisturizing agent for relieving symptoms of atopic dermatitis, and sedatives and nervous stabilizers are merely an adjuvant for symptom relief rather than a fundamental therapeutic goal.

Furthermore, these existing atopic treatment agents have different effects depending on the constitution of the individual, and in particular, the addition and use of an artificial chemical composition during the composition and the manufacturing process are premised. As a result, apart from the pharmacological components, they act as serious allergens The possibility is so great that it is difficult to trust its safety.

DISCLOSURE OF THE INVENTION Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a composition for treating and improving atopic dermatitis containing primary mineral water so as to suppress itching and inflammation, alleviate skin allergy, And a method for producing the composition for improving atopic dermatitis.

In order to attain the above object, the present invention provides a composition for treating and improving atopic dermatitis, comprising as an active ingredient, primrose mineral water, rhusin extract, green mud, and a mineral. The composition for treatment and improvement of atopy according to the present invention has an advantage that it can penetrate not only the epidermis but also the epidermis, thereby eliminating toxins and treating and improving atopic dermatitis.

According to the present invention, the composition of the present invention, which contains an extract of primrose mineral water, Rhodiola extract, Green mud, and minerals as an active ingredient, exhibits an effect of improving atopic dermatitis through histamine testing and the like, As a composition for improving atopic dermatitis, it can be usefully used for the development of cosmetics, medicines and foods for improving atopic dermatitis.

1 is an image showing a model for evaluating the histamine response of a composition according to an embodiment of the present invention.
2 is a graph showing the antioxidative activity of the composition according to an embodiment of the present invention.

Treatment of atopic dermatitis aims at the control of skin inflammation and pruritus, prevention of secondary lesion, and alleviates symptoms through treatment with moisturizer, antihistamine, local or systemic steroid. However, many patients do not respond well to these medications. In addition, side effects such as skin atrophy may occur when a steroid agent is applied for a long time. Therefore, there is a need for an agent that exhibits excellent atopic dermatitis-improving effects without side effects.

The present invention provides a composition for treating and improving atopic dermatitis, which comprises a primary mineral water as an active ingredient according to an embodiment of the present invention. Since the primordial mineral waters improve inflammation reaction and itching in atopic dermatitis patients and have a skin moisturizing effect, the composition according to the present invention containing the active ingredient as an active ingredient can treat and improve atopic dermatitis.

In order to accomplish the above object, a composition according to an embodiment of the present invention includes primary mineral water.

The primary mineral water may include 650 to 760 ppm of calcium carbonate, 31 to 44 ppm of sodium, 2.5 to 107 ppm of potassium, 23.9 to 304 ppm of calcium, and 2.34 to 54 ppm of magnesium. In addition, the primary mineral water may contain 8 to 22 ppm of germanium. Also, the primary mineral water may include 8828 to 10146 pCi / L of radon.

The composition may contain at least 50% by weight of the primordial mineral water, rhusi extract, green mud, and minerals in the rest of the composition.

The composition may further comprise one or more of Chamomilla Recutita Flower Extract, Portulaca Oleracea Extract, Sodium Hyaluronate, Coenzyme Q10, Aloe Barbadensis Leaf Juice, May further comprise any one additive selected from the group consisting of Arbutin, Camellia Sinensis Leaf Extract, Caviar Extract, and combinations thereof.

Hereinafter, the present invention will be described in more detail.

The composition according to one embodiment of the present invention comprises primary mineral water.

In the present invention, mineral water refers to a groundwater or spring water of a rock aquifer in which various minerals such as calcium, magnesium, potassium and the like are dissolved in rainwater permeating into rocks or into the ground, and also called mineral water, Management law 'as a spring water.

The mineral water is classified into hot spring, cold spring or cold mineral spring depending on the temperature at the time of elution on the ground, and the mineral spring usually refers to the latter, that is, cold mineral spring. One example of the cooling mineral is mineral water.

In the present invention, the primitive mineral water refers to the mineral water eluted from the Chosung-ri area of Naesu-eup, Cheongwon-gun, Chungcheongbuk-do, Republic of Korea and is classified as a cool mineral spring. According to the carbonated spring Chungbuk research reported in 1974 water temperature of the mineral water is invited in relation to the content of the carbonate, CO ₂ that state, that is, mineral jeongjeo not include the teller that the gas phase eluted at a chapter mineral 13 to 15 ℃ (井底) It has been reported that the concentration of free carbon dioxide (free CO ₂ ) contained in 1 kg of mineral water collected in water is 2,460 mg / l at the maximum.

The above-mentioned primary mineral water is not only a cold mineral spring but also rich in minerals, and thus is well suited for use as a cosmetic raw material, particularly as an essence raw material for a mask pack.

The primary mineral water may contain 650 to 760 ppm of the calcium carbonate. When the content of calcium carbonate in the primary mineral water is more than 760 ppm, irritation to the skin may be caused to form erythema, screech and edema, which may be unsuitable as a component of a cosmetic composition.

As the mineral water contains a large amount of natural minerals, it promotes metabolism and antioxidant activity in addition to its natural antimicrobial action and delays aging, thereby maintaining healthy and clear skin. In addition, the primordial mineral water has a sterilizing function and a skin soothing function that makes the skin normally breathable and prevents the bacteria from living on the skin, and as a result, the skin which does not function normally can be restored to a healthy and natural state .

In addition, the minerals contained in the primary mineral water are ionized in water and aged for a long time, so that they do not cause side effects on the skin.

The primordial mineral waters are rich in minerals and act on NMF-Natural Moisturizing Factor in skin cells to enhance moisture, thereby moisturizing the skin and removing dead cells (keratin) and waste products from the skin Excellent in function, cleans pores and skin cells to activate the function of the skin, and is excellent as a brightening effect, which is preferable as a material for a cosmetic composition.

The natural moisturizing factor is a natural moisturizing ingredient produced inside the body. It acts like a sponge in the keratinocyte, and the moisture content of the keratin is kept constant and the sebum secreted from the sebaceous gland prevents the evaporation of water, It prevents cracking and prevents water evaporation due to external environment.

Particularly, in the case of general essence cosmetics, since the content of purified water or water is 70% or more, the purified mineral water can be replaced with purified water or water in the production of cosmetics. When the purified water or water is replaced with the primary mineral water, excellent effects such as moisturizing, restoring skin fatigue, eliminating waste materials, brightening, skin soothing effect and germicidal effect can be given to the cosmetic.

The primary mineral water may include sodium, potassium, calcium and magnesium as major mineral components, and may further include germanium, manganese, silicon or selenium.

The calcium promotes metabolism, activates skin cells, contributes to maintaining skin health, and activates moisturizing factors of the skin. The magnesium plays a key role in cell metabolism, promotes the release of waste products, and activates the moisturizing factor of the skin. The selenium helps improve immunity and is a representative skin mineral (Beauty Mineral), which contributes to skin cell activation, antioxidative action and skin disease improvement.

Regarding the content of the component, the purified mineral water contains 31 to 44 ppm of sodium (Na), 2.5 to 107 ppm of potassium (K), 23.9 to 304 ppm of calcium (Ca), and 2.34 to 54 mg of magnesium (Mn), silicon (Si), selenium (Se), or the like as a small amount of a mineral component.

The germanium content of the primary mineral water is 1,000 times that of commercial water. The germanium accelerates the metabolism and normalizes the organs of the human body with the anticancer agent interferon derivative, thereby improving the pathological condition and has an effect of treating anemia .

In addition to the minerals, the primary mineral water contains 0.01 to 0.46 ppm of copper (Cu), 0.47 to 10.2 ppm of iron (Fe), 0.14 to 1.37 ppm of fluorine (F), 8.8 to 9.68 ppm of chlorine (Cl) 0.01 to 1.87 ppm of sulfate (SO4), 0.17 to 0.05 ppm of phosphorus (P) and 8 to 22 ppm of germanium. In addition, the primary mineral water may contain 8 to 22 ppm of germanium.

Sulfur contained in the sulfate helps delay cellular senescence, contributes to collagen formation, and has a function of making the skin clear and healthy. The copper protects the collagen of the skin to enhance the elasticity of the skin and contributes to the anti-inflammatory action. The iron is one of the skin minerals and makes a decisive contribution to the collagen and elastin production, the light proteins that make up the skin.

Table 1 below shows the results of analysis by KIST (KIST) and the National Institute of Health (NIED) on the content of inorganic substances in the primary mineral water, although the content of the primary mineral waters varies depending on the location of the mineral springs.

Mineral Sheets I (Unit: ppm) Mineral Sheets II (Unit: ppm) Mineral Sheets Ⅲ (Unit: ppm) Mineral Sheath Ⅳ (Unit: ppm) Na 31 44 39 31.8 K 2.6 105 107 2.5 Ca 125 304 118 23.9 Mg 32 54 47 2.34 Cu 0.05 or less 0.05 or less 0.12 0.46 Mn 0.77 1.24 1.84 2.96 Fe 1.0 6.8 10.2 0.47 F 0.33 1.37 0.8 0.14 Cl 9.2 8.8 8.8 9.68 SO ₄ 0.5 or less 0.5 or less 0.5 or less 1.87 Wellness O ₃ 620 1.070 840 96.5 P 0.05 0.05 0.17 - CaCO ₃ 650 760 750 -

In Table 1, the analysis of the mineral springs I to III was performed by the Korea Institute of Science and Technology, and the analysis of the mineral springs IV in the above Table 1 was performed by analyzing the mineral water after the water quality treatment, to be.

The composition may include 50% by weight or more of the above-mentioned primitive mineral water, preferably 70 to 90% by weight, based on the whole composition, and may contain the rattan extract, green mud, . If the content of the primary mineral water is less than 50% by weight, the effect of the primary mineral water may not be exhibited and may not act as purified water due to the addition of various additives.

In addition to the above components, the composition may further contain Chamomilla Flower Extract, Portulaca oleracea Extract, Sodium Hyaluronate, Coenzyme Q10, AloeBarbadensis Leaf Juice, , Arbutin, Camellia Sinensis Leaf Extract, Caviar Extract, and combinations thereof. At this time, the additive may be included in the total amount of the composition excluding the content of the components.

The green mud is a mineral produced by eruption of volcanic ash and lava due to volcanic eruption into the sea for a long time, These green muds are effective for the treatment and improvement of acne skin, and also have effects for removing impurities, sterilizing effect, toxin release, strengthening of pores and maintenance of oil ballast. The content of the green mud is preferably 0.1 to 5.0% by weight, more preferably 1.0 to 2.0% by weight based on the whole composition.

The plant extract may be one prepared by a conventional method for producing a plant extract.

The plant extract may be produced by a method such as a cold extraction method, a warm extraction method, a heat extraction method, an ultrasonic extraction method, and the like. Conventional extraction equipment, an ultrasonic pulverization extractor or a fractionator may be used. Examples of the plant extract include flowers, leaves, Or by adding a fractionation solvent to a crude extract prepared by adding an extraction solvent to a fruit or a crust or crushed water thereof or by extracting with an extraction solvent.

The extraction solvent may be at least one selected from the group consisting of water and an organic solvent. The organic solvent may be a polar solvent such as an alcohol having 1 to 5 carbon atoms, a diluted alcohol such as ethyl acetate or acetone, a nonpolar solvent such as ether, chloroform, benzene, hexane or dichloromethane, or a mixture thereof. The alcohol having 1 to 5 carbon atoms may be methanol, ethanol, propanol, butanol, or isopropanol, but is not limited thereto. In addition, the alcohol dilution water may be an alcohol diluted with water at 50 to 99.9% (v / v).

Further, the extract extracted with the solvent may be further fractionated with any one solvent selected from the group consisting of hexane, methylene chloride, acetone, ethyl acetate, ethyl ether, chloroform, water, and mixtures thereof. Two or more kinds of solvents may be used for the fractionation, and the solvent extracts may be sequentially used or mixed according to the polarity of the solvent. In addition, the fractionation process may be performed, for example, at 4 ° C to 120 ° C, or 50 ° C to 90 ° C, or 70 ° C to 85 ° C, but is not limited thereto.

The thus-prepared extract or the fraction obtained by performing the fractionation process may be filtered, concentrated or dried to remove the solvent, and may be subjected to both filtration, concentration and drying. Specifically, the filtration can be performed using a filter paper or a vacuum filter, and the concentration can be reduced by using a vacuum concentrator, for example, a rotary evaporator. The drying can be performed by, for example, freeze drying.

The rhus chinensis is also called the hornblende tree or the bamboo tree. The rhusi is distributed mainly in Korea, Japan, China and India. It belongs to the lacquer tree, but unlike other lacquer trees, it is not toxic. The thick branches are sparse and the small branches have yellowish brown hairs. Leaves are alternate phyllotaxis of 7-13 small leaves. Small leaf is ovate with coarse sawtooth and brown hairs on the back. The flower is a two-caroled flower. The conical flower is running on the axil end of stem, yellowish white, and hairs on flower ear. The fruit is yellowish red, yellowish brown, covered with yellowish brown hairs, ripened in October, and the white substance appears like salt on the surface of the fruit.

The Rhus verniciflua extract may be a plant extract using an extraction solvent, and may be an extract obtained by an extraction solvent or a fraction obtained by a fraction solvent. The content of the rhusi extract is preferably 0.1 to 5.0% by weight, more preferably 1.0 to 2.0% by weight based on the whole composition.

The above-mentioned march means the outpost of Portulaca oleracea. The marcheon is named after the leaf shape is similar to that of the horse's tooth, and the smoothness of the medicinal material is similar to that of the marrow. The leaves are blue, the stem is red, the flower is yellow, the roots are white, Because it has the meaning of five lines, it is called the five seconds.

The marjoram extract soothes the skin and protects the skin from external harmful environments. In addition, the mashin extract contains a large amount of organic acids, amino acids, vitamins A, B or C, carotene and tannic acid as well as excellent antimicrobial action, protects skin from various dermatitis, has antioxidative and astringent action, It has excellent control and antiallergic action.

Chamomilla Recutita refers to German Chamomile (Matricaria recutica). It is an annual plant with few fine hairs. Its stems are straight, round and have many side branches. Flowers bloom from May to September and have an apple flavor. The chamomile grows in sunny places, is enduring cold, and originates in the United Kingdom.

The chamomile flower extracts calms the skin, protects the skin, exhibits antioxidative and anti-inflammatory effects. The chamomile flower can be harvested after 8 weeks of sowing. After picking on a clear day, the chamomile flower is collected only in the sunshine and dried in the sun, and the extract is extracted from the dried flower blossom.

Citrus grandis is an evergreen arboreous tree of the dicotyledonous plant of the dicotyledonous plant. It grows in the tropical and subtropical regions of the Malayan Peninsula. The leaf and fruit are both large and the flower stalks are hairy. The fruit is flat ball shape and is about 17cm in diameter. The largest of the oranges is weighing 500 to 2,000 g and the skin is 1.5 to 2 cm thick. Because the flesh is sweet, it is eaten raw or it is made into sugar. Flesh color is light yellow and purplish, and the appearance is Western pear shape. It is grown in Jeju Island in Korea.

The green tea refers to a camelliasinensis leaf, and the tea tree is an evergreen tree or shrub of a dicotyledonous phloem phloem, and is distributed in the tropical, subtropical and temperate regions of Tibet and Chinese Sichuan province. have. The green tea, which is the leaf of the tea tree, is hard, slightly thick and glossy on the surface. Depending on the breed, there is a difference in the darkness of the leaf and the difference in the wrinkles. There are various colors such as green, purple, yellow and brown. The back of young leaves or young shoots has soft hairs.

The green tea extract has no side effects as a natural substance, and the catechin components extracted from green tea leaves contain tocopherol and vitamin C to prevent deposition of melanin pigment, inhibit formation of spots and freckles, inhibit the detoxification effect of alcohol nicotine , And deodorizing action. The green tea extract is rich in tannin components, and has excellent convergence and hygroscopicity for replenishing moisture. It also helps in bacterial suppression, antiallergic action, convergence and moisturizing, cleansing, and trouble-improvement, and is effective for stinging, freckles and acne.

Aloe Barbadensis is a kind of aloe that is a perennial herbaceous plant with lilies and is also referred to as Vivex aloe. Aloe is a perennial herbaceous plant of the genus Aloe, originating from the African continent, also known as the presbytery or tree prefecture. Aloe is widely grown today in tropical and temperate regions and is grown in many other areas.

The aloe vera leaves are long basaloids with sharp ends, slightly sharp thorns at the edge of the leaves, fleshy, without petiole, and out of the stem. When the aloe vera leaves are cut horizontally and its section is tilted downward, a yellowish juice drops off and the dried extract obtained by concentrating the juice is used as a medicinal product in the case of an alloe.

The aloe vera leaf juice has antibacterial and anti-inflammatory action, neutralizes dry skin and oily skin, and has a skin moisturizing effect. It also contains aloe tin, which has germicidal power against bacteria and fungi and neutralizes toxins, aloe vera effective for ulcers and alomitin for anti-cancer effects.

The caviar extract has effects on skin regeneration, wrinkles, elasticity improvement, anti-aging, moisture supply and nutrition. The above-mentioned caviar extract provides proper moisture and nutrition for living tissue, protects sensitive skin, and maintains elasticity constantly. In addition, the above-mentioned caviar extract provides moisture and nutrition suitable for living tissues such as proteins and vitamins, protects sensitive skin and keeps elasticity constant, improves the problem of skin hippie origin, At the same time, it exerts excellent functions for skin regeneration.

The sodium hyaluronate serves to supply and maintain moisture to the skin. The sodium hyaluronate is a moisturizing component present between the elastic fibers and the binding fibers to constitute a natural moisturizing factor of the skin. Since the hyaluronic acid is present in the skin of the newborn baby, it is very moist and moist, and the hyaluronic acid is aged The more.

Since the hyaluronic acid theoretically has the ability to attract water several hundreds of times its own weight and actually 80 times its own weight, the moisture retaining ability of the humectant is the most excellent. In addition, the hyaluronic acid is a substance that is contained in a certain amount in a human body, and acts as an intercellular substance that binds cells in the epidermis and dermis outside the skin to each other. The hyaluronic acid allows nutrients to be delivered to living cells, acts as a lubricant, prevents skin from evaporating, and absorbs moisture to maintain a proper amount of moisture in the skin. If ceramide is responsible for moisturizing the surface of the skin, the hyaluronic acid is responsible for moisturizing the skin.

That is, the hyaluronic acid acts as a lubricant, has excellent water-binding ability, increases the moisture of the skin, and strengthens the dermal tissue function.

The coenzyme Q10 maintains smooth skin, nourishes the skin, and helps antioxidants, anti-aging, anti-stain and anti-dullness.

Arbutin is used as an antioxidant, a skin conditioning agent and a brightening agent, and is one of the functional brightening ingredients notified by the KFDA. It suppresses the generation of spots, freckles, and dots due to abnormal pigment accumulation, It inhibits excessive melanin biosynthesis among skin lesions.

When used as an essence raw material for manufacturing a mask pack, the composition may further include an essence generally used for preparing a mask pack or an auxiliary agent generally contained in the cosmetic composition.

Specifically, the cosmetic composition may include butylene glycol, glycerin, betaine, collagen, PEG-60 Hydrogenated Castor Oil, Dipotassium Glycyrrhizate, Sodium citrate, Sodium Carbomer and the like, and may include alcohols such as phenoxyethanol, and the like. And Ciel oil, and may also contain natural preservatives and the like.

At this time, the adjuvant may be included in the rest of the composition except for the content of the primitive mineral water or the active ingredient.

Another embodiment of the present invention can provide a cosmetic composition comprising the composition for treating and improving atopic dermatitis. The cosmetic composition has no side effects on the skin and has a skin soothing effect, a moisturizing effect, a brightening effect and a exfoliation effect.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

Example

Example  One

Mineral water was extracted from Chosung-ri area, Naesu-eup, Cheongwon-gun, Chungcheongbuk-do, Korea. The primary mineral waters contained 760 pmm calcium carbonate, 44 ppm sodium, 105 ppm potassium, 304 ppm calcium and 54 ppm magnesium, including 15 ppm germanium and 8898 pCi / L of radon.

The above ground mineral water was mixed with the components listed in Table 2 below to prepare a composition. The mixing and mixing of the compositions generally used the method used for the production of cosmetic compositions.

Raw material name Content (% by weight) Actual amount (kg) Primary mineral water 85.53 222,378 Butylene Glycol 3.00 7,800 Glycerin 4.00 10,400 Betaine 1.50 3,900 Green Mud 1.00 2,600 Aloe Barbadensis Leaf Juice 0.50 1,300 Collagen 1.00 2,600 Alcohol 1.00 2,600 PEG-60 Hydrogenated Castor Oil (PEG-60 Hydrogenated Castor Oil) 0.20 520 Phenoxyethanol 0.20 520 Ciel Oil (perfume) 0.02 52 Rhus chinensis Extract 1.00 2,600 Portulaca Oleracea Extract 0.10 260 Chamomilla Recutita Flower Extract 0.10 260 Arbutin 0.10 260 Sodium Carbomer 0.20 520 Natural preservative 0.20 520 Dipotassium Glycyrrhizate < RTI ID = 0.0 > 0.10 260 Sodium Hyaluronate < RTI ID = 0.0 > 0.05 130 Sodium citrate 0.20 520 Sum 100.00 260,000

Comparative Example  One

A composition was prepared in the same manner as in Example 1 except that general purified water was used in place of the primed mineral water.

Claims (5)

delete delete delete delete 1.0% by weight of glycerin, 1.5% by weight of betaine, 1.0% by weight of green mud, 0.5% by weight of aloe vera leaves, 1.0% by weight of collagen, 1.0% by weight of alcohol, PEG-60 0.2% by weight of hydrogenated castor oil, 0.2% by weight of phenoxyethanol, 0.02% by weight of seed oil, 1.0% by weight of rhusiek extract, 0.1% by weight of extracts of march, 0.1% by weight of chamomile flower extract, 0.1% by weight of arbutin, 0.2% , 0.2% by weight of a natural preservative, 0.1% by weight of dipotassium glycyrrhizate, 0.05% by weight of sodium hyaluronate and 0.2% by weight of sodium citrate.

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