KR102256711B1 - Composition for preventing hair loss comprising tormaline and mixed natural herb extracts - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss comprising tourmaline and a complex natural product, and more particularly, to a composition for preventing hair loss prepared by using a composition optimized by using tourmaline and various natural ingredients, efficiently extracting each of the ingredients in consideration of the useful functionality, side effects and the like of each ingredient, and blending the same at an appropriate blending ratio thereof. The composition for preventing hair loss of the present invention is formulated with a tourmaline extract and an extract of the complex natural product to promote hair growth and prevent hair loss, and also provides various effects in combination such as moisturizing, treatment, antibiotics, anti-inflammation, sebum secretion suppression, blood circulation promotion, dandruff removal, hair cell activity, etc., can help to make hair more elastic and smooth, and can be efficiently used as a new concept functional essence composition that can be sprayed as a quasi-drug. In addition, the composition improves blood circulation, helps cell regeneration, and has excellent pain relief, anti-inflammatory, antibacterial, skin soothing, and skin moisturizing effects.

Description

Composition for preventing hair loss comprising tormaline and mixed natural herb extracts}

The present invention relates to a composition for preventing hair loss comprising tourmaline and a complex natural product, and in more detail, each component is efficiently extracted in consideration of the useful functionality and side effects of each component using tourmaline and various natural product components. It relates to a composition for preventing hair loss prepared using a composition optimized by blending by an appropriate blending ratio.

Human hair has different cycles and grows and falls off through the anagen, catagen, and telogen. This cycle is repeated over 3 to 6 years, and an average of 50 to 100 hairs per day are normally removed.

In general, alopecia refers to an abnormal increase in the number of hairs that are dropped out due to the shortening of the growth period hairs and the increase of degenerative or telogen hairs during such a cycle.

Various causes of hair loss are known. For example, it is well known that testosterone, a male hormone, affects hair loss, especially with regard to hair loss. Looking at the effect of male hormones on hair loss, testosterone combines with the 5α-reductase enzyme in the body to produce dihydroxytestosterone (hereinafter referred to as'DHT'). It binds to the androgen receptor in the hair follicle and has a dominant effect on inhibiting the hair follicle formation in the hair follicle. Therefore, studies to develop a substance for preventing hair loss using an inhibitor of 5α-reductase enzyme are currently being actively conducted.

In addition, male pattern hair loss due to genetic influence, circular hair loss due to autoimmune abnormalities due to stress, telogen hair loss after delivery due to the influence of hormones such as estrogen in late pregnancy, hair loss due to malnutrition and metabolic disorders, skin diseases, dead skin cells, There are hair loss due to abnormal scalp environment such as dandruff, and hair loss due to scalp stimulation through chemical procedures such as dyeing or perm.

As a hair growth agent currently on the market, agents containing as main components such as minoxidil of Upzone of the United States and trichosaccharide of Crinos, Co of Italy are used, but the absence of distinct effects and side effects problems are emerging. In addition, finasteride developed by Merck is known as a substance that inhibits the activity of 5α-reductase, an enzyme that acts on the male hormone testosterone metabolism in hair follicles, but it can cause depression. It has a problem that it requires long-term treatment. In addition to these, there are cresina and rogain, but they are used only when the hair roots are alive on the normal scalp before the hair loss disease progresses completely. As such, conventional various types of hair regrowth agents have been attempted to aid in hair growth for the purpose of promoting blood circulation of the scalp and supplying nutrients to the hair roots, but the current situation is that the toxicity and side effects are severe and their effects are also insufficient.

Regarding the prevention of hair loss, a number of hair care products such as shampoos for preventing hair loss have recently been released. However, even if it contains a large number of irritating chemical ingredients or contains natural ingredients, it has a low-irritating effect, such as the remaining chemical ingredients in the form of an extract, as well as a product that satisfies the moisture and shine of hair, prevention of hair loss and promotion of hair growth at the same time Is inadequate.

Accordingly, recently, research on hair loss treatment that does not cause side effects even with long-term use has been actively conducted by using various new substances extracted from natural products.

Therefore, studies on substances derived from natural plants that are safe and excellent in preventing hair loss are actively underway, and it is more desirable to develop products that help prevent hair loss by targeting traditionally proven natural substances rather than synthetic substances that cause side effects. It may be more desirable.

Korea Registration No. 10-1961595 (March 18, 2019) Korea Registration No. 10-1274868 (June 7, 2013) Korea Registration No. 10-1390108 (April 22, 2014)

As a result of intensive research to develop functional materials for various natural products based on long experience with natural products, the present inventors consider useful functionality and side effects of each component by using various natural product ingredients as described below. Thus, it was discovered that the formulation prepared using a composition optimized by efficiently extracting each component and blending at an appropriate blending ratio has no side effects and can help prevent hair loss, and the present invention has been completed.

Accordingly, it is an object of the present invention to provide a composition for preventing hair loss that is optimized by efficiently extracting each component by using tourmaline and various natural herbal ingredients in consideration of the useful functionality and side effects of each component, and blending it at an appropriate mixing ratio. There is.

The object of the present invention as described above is 9 to 11 parts by weight of tourmaline powder, 7 to 9 parts by weight of dietary sulfur powder, 0.4 to 0.6 parts by weight of licorice extract, 0.7 to 0.9 parts by weight of purslane extract, turmeric extract based on 100 parts by weight of the total composition. 0.9 to 1.1 parts by weight, peppermint brain extract 2.5 to 3.5 parts by weight, red tree extract 0.9 to 1.1 parts by weight, Wiryeongseon extract 1.3 to 1.7 parts by weight, Tangja extract 1.0 to 1.4 parts by weight, Eoseongcho extract 1.2 to 1.4 parts by weight, Perilla extract 1.2 Tourmaline and a complex natural product comprising ~1.4 parts by weight, 0.4 to 0.6 parts by weight of green tea extract, 2.3 to 2.7 parts by weight of lecithin, 4.5 to 5.5 parts by weight of olive oil, 8 to 12 parts by weight of vegetable ethanol, and the balance of purified water. It can be achieved by a composition for preventing hair loss, including.

The hair loss prevention composition of the present invention not only prevents hair generation and hair loss, but also moisturizes, treatments, antibacterial, anti-inflammatory, sebum secretion, blood circulation promotion, dandruff removal, hair cell activity, etc. It can provide various effects in combination, can help to make hair more elastic and smooth, and can be effectively used as a new concept functional essence composition that can be sprayed in the form of a spray as a quasi-drug. In addition, it improves blood circulation, helps cell regeneration, and has excellent effects such as pain relief, anti-inflammatory, antibacterial, skin soothing, and skin moisturizing.

1 is a manufacturing process diagram of the anti-hair loss composition of the present invention.
2 to 6 are photographic data confirming the condition of the hair before and after use for a certain period of time.

In one aspect, the present invention,

Tourmaline powder 9 to 11 parts by weight, dietary sulfur powder 7 to 9 parts by weight, licorice extract 0.4 to 0.6 parts by weight, purslane extract 0.7 to 0.9 parts by weight, turmeric extract 0.9 to 1.1 parts by weight, peppermint brain based on 100 parts by weight of the total composition Extract 2.5-3.5 parts by weight, Redwood extract 0.9-1.1 parts by weight, Wiryeongseon extract 1.3-1.7 parts by weight, Tangja extract 1.0-1.4 parts by weight, Eoseongcho extract 1.2-1.4 parts by weight, Perilla extract 1.2-1.4 parts by weight, Green tea extract Provides a composition for preventing hair loss comprising tourmaline and a complex natural product comprising 0.4 to 0.6 parts by weight, lecithin 2.3 to 2.7 parts by weight, olive oil 4.5 to 5.5 parts by weight, vegetable ethanol 8 to 12 parts by weight, and the balance of purified water do.

The composition provides a composition for preventing hair loss comprising tourmaline and a complex natural product, which is used as a spray product.

The present invention, in another further aspect,

The above complex natural products

a1) Putting the vegetable material into the extractor, adding 10 to 25 times water or organic solvent based on the weight, and then brewing for 6 to 72 hours at a medium temperature of 0.5 to 0.6 atm and 70 to 95 °C and extracting

a2) It provides a composition for preventing hair loss comprising tourmaline and a complex natural product, which is obtained by filtering the obtained extract.

The present invention was made as a result of diligent efforts to develop a formulation having the functionality of preventing hair loss using various complex natural products, and was mainly focused on optimizing various complex natural product ingredients, their combination ratio, and efficient extraction conditions of each ingredient. There are characteristics, and the composition ratio of the composition according to the present invention is set based on the results of a long study in consideration of the effective dose and side effects of each component, and if it is out of the range of the ratio, a desirable synergistic effect with other components is achieved. There is a fear that the effect may be deteriorated because it cannot be displayed.

Hereinafter, each individual component will be described.

First, tourmaline (tourmaline) is a silicate mineral containing boron, and when it comes into contact with moisture, it is electrolyzed instantaneously and generates a large amount of anions of about 2000 per 1cc.

In addition, tourmaline is characterized by emitting far-infrared rays as well as such a large amount of anions, and contains abundant cations such as sodium and magnesium, which are biomaterials, and minerals such as silicon, boron, magnesium, and iron. Therefore, when tourmaline is applied to a living body, it is known that it warms the cells and improves blood circulation to activate the cells, so that it has various biological effects such as cell regeneration, blood purification, immunity enhancement, and autonomic nerve regulation.

The tourmaline may be preferably used in the form of a powder of 500 ~ 2,000 mesh.

Dietary sulfur (MSM, Methyl Sulfonyl Methane) is a product of oxidative metabolism of dimethyl-sulfoxide (DMSO) containing 34% sulfur, and is a natural organic form of bioavailable sulfur.

In Korea, sulfur has been mainly used as a prescription for dermatitis, and a prescription for ringworm is cured by mixing sulfur, alum, garlic, nogamstone, zinc oxide, and vinegar at an appropriate ratio and applying it to the affected area. Do.

When sulfur is applied to the skin, pentathionic acid (HO-SO2-S3-SO2-OH) is formed by reacting with organic substances, and this substance dissolves dead skin cells and acts as an insecticidal and sterilizing agent. Therefore, sulfur is reported to play a good role in dermatitis due to its strong sterilization and sterilization as a non-toxic supply of sulfur elements.

The dietary sulfur may be preferably used in the form of a powder of 500 ~ 2,000 mesh.

Licorice is a perennial herb of the legume family, and it has a subterranean stem that is vine in wood and a root that extends deeply into the ground. The site of use is a 3-year-old root and a stem in the ground, and the yakseong is normal and the taste is sweet. In addition, licorice is widely used in medicines, tobacco, and food products. Expectant, stool pain, soothing convulsions, anti-allergic, antibacterial, antiviral, biliary stimulation, fever, antitussive, muscle relaxation, liver protection and anti-cancer activity, and other activities, including common cold, cough, bronchitis, gastric ulcer and duodenal ulcer, arthritis, rash , Hepatitis, liver and kidney cirrhosis, menstrual pain, Edison's disease (adrenal cortical insufficiency), eczema and herpes simplex, cholesterol, trichomonas infection, drug or food addiction, fatigue, fever, heart palpitations, etc. Of course, it is one of the most widely used herbal medicines because it is often used for flavoring when preparing other medicines.

Purslane is a perennial plant, and is also called as five, machichae, sansanchae, jangmyeongchae, ragweed, thief grass, and horse manicure. It is an edible fleshy plant commonly found in low mountains and fields nationwide.

Purslane contains tannin, saponin, beta-carotene, potassium, calcium, phosphorus, iron, alkaloids, coumarin, flavonoids, and omega-3 fatty acids. 3 Fatty Acid), it removes toxins, sterilizes, kills, and suppresses toxins, which are the causes of various diseases, has excellent diuretic properties, smoothes metabolism, and has anti-cancer and antioxidant effects. In particular, the omega-3 fatty acid component facilitates blood circulation and lowers blood pressure by releasing cholesterol or triglycerides out of the body, and arrhythmia, coronary atherosclerosis, high blood pressure, diabetes, cancer, arthritis, thrombocytopenia or multiple sclerosis It has the effect of preventing and improving skin diseases such as immune disease, colitis, dry ringworm or boil. In addition, the omega-3 fatty acid component is distributed in the nerve cell membrane and the retina, and serves to transmit electrical stimulation from the cell membrane to the next cell at a high speed, stress, depression, schizophrenia, attention deficit hyperactivity disorder, vision loss, It has the effect of preventing heart disease and dementia.

Turmeric refers to the tuber root of Curcuma longa Linne, an annual herb of the Ginger tree family, and the roots of Curcuma longa Linne are removed or steamed and dried. The height is about 1-15 m, the root is like ginger, and flowers bloom in late summer.

In ancient books such as Bonchogangmok and Donguibogam, it is recorded that ``Turmeric moisturizes the detoxification of the liver and has excellent bile secretion and bleeding effects.'' In particular, curcumin, a diketone compound among its main components, is known to have excellent anticancer effects, and has antitumor, antioxidant, antiamyloid and anti-inflammatory effects. In addition, curcumin inhibits DNA damage and oxidation caused by oxidation, and acts as an antioxidant and scavenger of free radicals. In addition, it has been confirmed that curcumin inhibits the formation of plaques in the brain, which is considered the cause of Alzheimer's, and has the effect of destroying plaques already formed.

Mint brain (menthol) is known as the main component of mint. According to traditional oriental medicine, peppermint is known to have a cooling action, spasolysio effect, and a fertility effect and a haepyo effect. It is also known to promote blood circulation by acting on the vascular center and relaxing blood vessels. This effect is known to be due to menthol, the main component of mint, and it is known to exhibit blood circulation effects through the strong scent and stimulation unique to menthol.

Rhus chinensis is a lead-free shrub of the Sumacaceae family, and is also called a hornbeam or a salt splint. It belongs to the sumac tree, but unlike other sumac trees, it is not toxic. Thick branches appear sparse, and small branches have yellowish brown hairs. Leaves are alternate, pinnate compound leaves consisting of 7 to 13 small leaves, small leaves are egg-shaped, with thick serrates, and brown hairs on the back side. The flower is a two-family flower, with conical inflorescences coming out from the axils of the stem end, yellowish white, and hairs on the ear of the flower. The fruit is a piliform drupe, yellowish red, covered with yellowish brown hairs, and ripens in October. On the outside of the fruit, a white substance looks like salt.

Wiryeongseon (威靈仙, Radix Clematidis) is a deciduous perennial belonging to the Ranunculaceae (Ranunculaceae) plants euahri Castle (Clematis mandshurica MAXIM, Clematis mandshurica RUPR ), Hankuk University of Foreign Studies euahri (gochitdae flowers) (Clematis brachyura MAXIM), true euahri (Clematis paniculate THUNB), Clematis florida THUNB, Clematis patens MORREN, and the roots and rhizomes of related plants are dried.In China, Clematis chinensis OSBECK and Clematis hexapetala PALL are used together. It is the origin. These viryeongseons are known to have analgesic action, antimalarial action, antibacterial action, lactic acid action, bile secretion promoting action, smooth muscle relaxation action, anti-diuretic action, cardiac and blood pressure lowering action.

Tangja is the fruit of the tangja tree. It is green on the outside and white on the inside, and has a unique scent. When the tangja is undercooked, it is called jisil (枳實), which is cut into two or three pieces and dried, and the dried skin is called crust, and is used as a medicinal material in oriental medicine. Jisil is used as a cure for eczema, and crust is used for diarrhea and enema. In addition, it is also used for stomach medicine, indigestion, uterine drainage, and intestinal dysfunction. Flowers contain essential oils such as limonen and linalool, and fruits contain essential oils such as naringin and poncirin.

Houttuynia cordata is a perennial herb belonging to the Saururaceae family. It has a'fishy smell' from its leaves and stems, so it is called Eoseongcho (漁腥草). In China, Eoseongcho is widely known as an herbal medicine rather than as a folk medicine, and is also known as punghyeongcho (肺形草), walnutcho (好頭草), and Guzai (拘子耳). According to Bonchogangmok, Eoseongcho is known to be effective in four fever, detoxification, diuresis, purulent, detoxification, and anti-inflammatory, and it is clinically applied to whooping cough, bronchitis, pneumonia, tonsillitis, etc. Is being used. The main ingredient contains quercitrin, and recent studies have reported the blood pressure lowering, blood sugar lowering, antibacterial, antiviral, anti-inflammatory and anti-allergic, and antioxidant effects of Eoseongcho extract. There is a bar.

Perilla frutescens var acuta is a herbaceous plant belonging to the Lamiaceae family, and its height is 30 to 60 cm, and is called niche, perilla and perilla perilla. It is produced in Korea and China, and is used for edible or medicinal purposes. Perilla leaves are purple and have a peculiar flavor, and the stem is angular and straight, and the leaves are round or wedge-shaped at the bottom, and there are serrated at the edge. The flower is pale purple, and blooms as a raceme around August-September, and the shape of the mouth and stem is similar to that of perilla. The main ingredients are perilla aldehyde, d-limonene, α-pinene, cyanin, sterin, menthol, and rosmarinic acid. , Luteolin, etc. are known, and there are studies that show that when consumed by participating in meat or fish, it prevents food poisoning and has strong antibacterial activity.

Green-tea ( Camellia teaceac ) is a non-alcoholic favorite drink containing caffeine along with coffee, cocoa, and black tea, and is one of the favorite drinks that Koreans have enjoyed drinking since ancient times. Green tea is known to have a function of supplying nutrients of vitamins and minerals, and satisfying preferences such as taste and aroma, and out of 100 mg of dry green tea leaves, carotene is 13 mg, vitamin E is 654 mg, and It is reported that it contains 106 mg of dietary fiber and rich in minerals such as Ca, Fe, and K. Among these green teas, the main component of astringency is catechin, which is a polyphenol component, and catechins are Epicatechin, Epigallocatechin, Epicatechin gallate and Epigal depending on their derivatives. It can be classified as Epigallocatechin gallate. Catethin content reaches about 8-20% of dry green tea, and it is water-soluble and elutes into water when boiled with water. The bitter taste of green tea is mainly due to caffeine, which is known to have arousal, diuretic, and fatigue-relieving effects, and the ingredient that gives off its unique taste is theanine, which is the ethylamide of glutamic acid. Accounts for about half, and contains more than 20 kinds of amino acids.

On the other hand, green tea contains various physiologically active substances. In particular, catechins have the function of inhibiting the formation of blood clots and preventing arteriosclerosis by reducing LDL cholesterol in the blood, inhibiting the production of lipid peroxide, and preventing fatty acidization. As it turns out, it is also used as a natural antioxidant. In addition, green tea is known to prevent food poisoning by preventing aging, inhibiting the proliferation of cancer and inhibiting carcinogenesis, as well as having an antitoxin effect that neutralizes toxins. In particular, epigallocatechin gallate contained in green tea was found to be the main effective substance, and it has strong antioxidant activity 25 times more than vitamin E and 100 times more than vitamin C, so it can be used to prevent or preserve lipid oxidation in seafood. In recent years, it has been proven to be effective in removing heavy metals.

Lecithin is a key component of phospholipids isolated from yolk (Lekithos) and is also called phosphatidylcholine.

The lecithin is a constituent of the biological membrane in the human body and is related to an important life phenomenon that determines the properties of the biological membrane, such as permeability and emulsification. In addition, the lecithin has an effect of preventing myocardial infarction by lowering the surface activity and reducing the amount of cholesterol in the blood in vivo. In addition, the lecithin promotes absorption of fat-soluble substances such as vitamin A and vitamin E and prevents aging.

Olive oil is rich in oleic acid, which helps prevent atopy, prevents skin aging, improves joint health, and improves blood circulation. It is effective in reducing inflammation, pain, and preventing aging, and is also used as a surfactant.

Ethanol is a component that is helpful in relieving inflammation, and vegetable ethanol or grain fermented alcohol may be more preferably used.

1 is a manufacturing process diagram of the anti-hair loss composition of the present invention. The above-mentioned plant extract can be extracted as follows.

First, after removing foreign substances in step a1), put the pretreated vegetable material into the extractor, add 10 to 25 times water or organic solvent based on the weight, and then add 6 to 0.5 to 0.6 atmospheres and at medium temperature of 70 to 95 °C. It is brewed and extracted for a period of time to 72 hours.

As the organic solvent, alcohol, ethanol, or a mixed solvent thereof may be used.

The amount of solvent showed good results when extracted in 10 to 25 times as a result of the experiment for standardizing the amount of solvent used, and when comparing energy efficiency and economy, it may be more efficient to extract by adding the solvent in 10 times. It is recommended to perform the extraction pressure under the conditions of 0.5 to 0.6 atmospheres. There is a concern that the content of the active ingredient may be lowered when the medium temperature extraction conditions are exceeded.

Then, in the a2) filtration step, solid foreign substances and particles may be filtered out using, for example, a filtration membrane, paper filter paper, nonwoven fabric or cotton, or filtered using an ultrafiltration method, a cryofiltration method, a centrifugal separation method, or the like. In addition, filtration may be performed by first filtering using gauze and then second filtering using Whatman paper.

The composite natural product undiluted solution is prepared by mixing the extracted complex natural product and tourmaline powder and oil processed through a procedure such as pulverization in advance in an appropriate ratio as described above.

If necessary, the undiluted composite natural product may be sterilized and stored by a method such as ultraviolet irradiation, and then diluted with an appropriate multiple before use.

In addition, the anti-hair loss composition according to the present invention can be formulated according to the purpose of use as cosmetics, quasi-drugs, especially spray products.

When the anti-hair loss composition of the present invention is prepared as a cosmetic, it may include ingredients commonly used in the cosmetic composition, and for example, conventional antioxidants, stabilizers, dispersants, preservatives, solubilizers, vitamins, pigments, and fragrances. It may include an adjuvant, and a carrier.

The cosmetic composition of the present invention may be prepared in a conventionally prepared formulation, for example, hair tonic, hair conditioner, hair essence, hair lotion, hair nutrition lotion, hair shampoo, hair rinse, hair treatment, hair cream , Hair nutrition cream, hair moisture cream, hair massage cream, hair wax, hair aerosol, hair pack, hair nutrition pack, hair soap, hair cleansing foam, hair oil, hair dryer, hair preservation agent, hair dye, hair wave agent, hair bleaching agent , Hair gel, hair glaze, hairdresser, hair lacquer, hair moisturizer, hair mousse, hair spray, etc. may be manufactured in various forms, but is not limited thereto.

The hair loss prevention composition of the present invention not only prevents hair generation and hair loss, but also moisturizes, treatments, antibacterial, anti-inflammatory, sebum secretion, blood circulation promotion, dandruff removal, hair cell activity, etc. It can provide various effects in combination, can help to make hair more elastic and smooth, and can be effectively used as a new concept functional essence composition that can be sprayed in the form of a spray as a quasi-drug. In addition, it improves blood circulation, helps cell regeneration, and has excellent effects such as pain relief, anti-inflammatory, antibacterial, skin soothing, and skin moisturizing.

<Example>

Hereinafter, the present invention will be described in more detail through examples. These examples are only for describing the present invention in more detail, and it will be apparent to those of ordinary skill in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Example 1: Preparation of composite natural product composition

Each of the complex natural products purchased on the market is 1 kg tourmaline powder, 800 g dietary sulfur powder, 50 g licorice extract, 80 g purslane extract, 100 g turmeric extract, 300 g peppermint brain extract, 100 g redwood extract, 150 g Wiryeongseon extract, 120 g tangja extract, 130 g Eoseongcho extract. , Perilla leaf extract 130g, green tea extract 50g, lecithin 250g, olive oil 500g, vegetable ethanol 100g, and the remaining amount of purified water (total 10 Kg) were mixed to obtain a composite natural product composition in an undiluted state.

For each extract, a vegetable material was put in an extractor, 20 times of water was added based on the weight, and then extracted by brewing for 8 hours at a medium temperature of 0.6 atm and 75°C, and then a foreign substance was filtered from the obtained extract.

Example 2: Preparation of spray formulation

The composite natural product composition of Example 1 was diluted 10-fold with distilled water, a small amount of dispersant was added, and 200 ml each was dispensed into a spray container to prepare a spray formulation.

Example 3: Acute toxicity test

A toxicity test was performed on the composite natural product composition according to Example 1, and the presence or absence of toxicity was observed. As the experimental animals, 60 SD rats of a body weight of 105±4g male and 95±3g female of 4 to 5 weeks old were used, and the preparation of the present invention and distilled water were used as a negative control group. First, the rats were subjected to about 1 in a laboratory breeding box equipped with a temperature of 22±2℃, a relative humidity of 53±2%, a fluorescent lamp lighting (09:00 lit-18:00 turned off), and a lighting condition of 150-300 Lux. After acclimatization over a period of about a week, only healthy animals are selected, divided into groups so that the average weight is consistent, and forcibly administered orally in an amount of 20ml/kg once a day for 14 days, then changes in general condition, symptoms of poisoning , Motility, appearance, autonomic nerves, weight change, and the presence or absence of dead animals were checked.

According to the results of the experiment, there was a change in body weight within 5% during the experiment, but there was no significance, and even though the highest concentration of 20ml per kg, which is the maximum amount that can be administered to the test animal, was selected for the amount of the sample, no dead animals were observed. Since it was impossible to calculate the lethal dose of, the LD ₅₀ was found to be more than 20ml/kg BW, and no specific general symptoms or specific lesions were observed at autopsy.

Example 4: Hair condition test

In order to evaluate the prevention of hair loss and promotion of hair growth with respect to the product of Example 2 of the present invention, a sensory test was performed on 50 volunteers currently having alopecia. The test was carried out for 2 months, and the testers sprayed 20 ml of the formulation of Example 2 onto the scalp on average twice a day. The evaluation scale of the results for the degree of improvement in hair loss-related test items was a 5-point scale (5 points: significant improvement, 4 points: significant improvement. 3 points: slight improvement, 2 points: slight improvement, 1 point: no difference). .

As for the test items, a total of six sensory items were evaluated, such as hair loss improvement, hair growth effect, hair elasticity, dandruff removal, skin troubles, and comprehensive evaluation, and the results were evaluated by Duncan's multiple range test at 5% level using ANOVA. Significant differences between the livers were verified. The results are shown in Table 1 below (average value ± standard deviation). A commercially available one was used as a comparative product.

Item Example 2 Comparative example Hair loss improvement 4.65±0.54 1.21±0.45 Hair growth effect 3.32±0.76 1.05±0.30 Hair elasticity 4.36±0.31 2.21±0.37 Dandruff removal 4.21±0.62 2.25±0.73 Skin trouble improvement 4.75±0.78 2.66±0.30 Overall improvement 4.33±0.33 2.07±0.35

As a result, the product of Example 2 showed quite satisfactory results overall in terms of preventing hair loss. From the results of Table 1, it was confirmed that the products of the examples of the present invention were generally superior to the comparative products, regardless of age group.

Example 5: Hair growth promotion clinical test

In relation to Example 4, the testers were continuously observed and photographic data were obtained at regular intervals, and the results are shown in FIGS. 2 to 6. 2 to 6 are photographic data confirming the condition of the hair before and after use.

In the case of FIG. 2, a photo of a volunteer who applied the product of the present invention for one week, FIG. 3 is a photograph of a volunteer who applied the product of the present invention for two weeks, and in the case of FIG. 4, the product of the present invention was applied for one month. Figure 5 is a photo of a volunteer who applied the product of the present invention for 7 weeks, and FIG. 6 is a photograph of a volunteer who applied the product of the present invention for 2 months.

As can be seen from these photographic data, the spray product according to the exemplary embodiment of the present invention has a visual observation of the function of preventing hair loss, including increasing the elasticity of the hair, increasing the number of hair, and improving the skin condition.

From the above results, the anti-hair loss composition according to the present invention is provided as a pharmaceutical or quasi-drug related to hair loss prevention by confirming various types of hair loss-related efficacy, and used as a product for maintaining a healthy life, and for secondary diseases such as stress suppression. It can also be used in the prevention-oriented healthcare industry, which can be continuously consumed without side effects for the purpose of prevention.

In the above, preferred embodiments of the present invention have been described, but those of ordinary skill in the art to which the present invention pertains can understand that the present invention can be implemented in other specific forms without changing the technical spirit or essential features. There will be. Therefore, it should be understood that the exemplary embodiment described above is illustrative in all respects and is not limiting.

Claims (3)

Tourmaline powder 9 to 11 parts by weight, dietary sulfur powder 7 to 9 parts by weight, licorice extract 0.4 to 0.6 parts by weight, purslane extract 0.7 to 0.9 parts by weight, turmeric extract 0.9 to 1.1 parts by weight, peppermint brain based on 100 parts by weight of the total composition Extract 2.5-3.5 parts by weight, Redwood extract 0.9-1.1 parts by weight, Wiryeongseon extract 1.3-1.7 parts by weight, Tangja extract 1.0-1.4 parts by weight, Eoseongcho extract 1.2-1.4 parts by weight, Perilla extract 1.2-1.4 parts by weight, Green tea extract It consists of a complex natural product containing 0.4 to 0.6 parts by weight, lecithin 2.3 to 2.7 parts by weight, olive oil 4.5 to 5.5 parts by weight, vegetable ethanol 8 to 12 parts by weight, and the balance of purified water,
Each of the above plant extracts a1) put the vegetable material in the extractor, add 10 to 25 times water or organic solvent based on the weight, and then in the brewing for 6 to 72 hours at a medium temperature of 0.5 to 0.6 atmospheres and 70 to 95 °C. A composition for preventing hair loss comprising tourmaline and a complex natural product, which is obtained by obtaining a fish extract and a2) filtering the obtained extract, and is used in the form of a spray product. delete delete

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