JP2016222612A - Cosmetic and skin external preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a cosmetic or a skin external preparation capable of sufficiently obtaining an effect by incorporating a pantothenic acid derivative and/or a salt thereof.SOLUTION: There is provided a cosmetic or a skin external preparation which contains a pantothenic acid derivative represented by the following general formula (1) and/or a salt thereof and an effect enhancing agent. (wherein, Rand Reach independently represent a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms; the hydrocarbon group bonded to a carbonyl carbon of the acyl group is a saturated or unsaturated hydrocarbon group, and at least one of Rand Ris the acyl group.)SELECTED DRAWING: None

Description

  The present invention relates to a cosmetic or an external preparation for skin.

Pantothenic acid, also called vitamin B5, is a component of coenzyme A that is essential for carbohydrate, lipid and protein metabolism and energy production. Pantothenic acid is also involved in the synthesis of cholesterol, hormones, immune antibodies and the like.
Furthermore, pantothenic acid is involved in the production of epidermal cell growth factors and collagen precursors (see, for example, Non-Patent Document 1) and has a proliferative effect on fibroblasts (see, for example, Non-Patent Document 2). .)It has been known.

Thus, pantothenic acid is an important compound involved in various functions in the living body, and when deficient, various symptoms appear in the living body.
For example, when pantothenic acid is deficient, sebum secretion is disturbed and skin turnover is not performed normally, dermatitis, acne, rough skin, and the like are caused. It is also known that deficiency of pantothenic acid causes white hair and alopecia (see, for example, Patent Document 1).

JP-A-6-305940

Exp Dermatol; 18 (11) 969-78, 2009 Int J Vitam Nutr Res; 69 (2) 113-9, 1999

  However, in order to improve various symptoms caused by pantothenic acid deficiency, the above symptoms may not be sufficiently improved even if conventional pantothenic acid derivatives and salts thereof are used alone as cosmetics or skin external preparations. .

  The present invention has been made in view of the above circumstances, and the effect of including a pantothenic acid derivative and / or a salt thereof can be sufficiently obtained and / or the performance as a preparation such as an improvement in storage stability can be improved. It is an object of the present invention to provide an achieved cosmetic or skin external preparation.

  The inventors of the present invention have made extensive studies to solve the above problems. As a result, by including a specific pantothenic acid derivative and / or salt thereof and an effect promoter, improvement of effects on the human body and / or improvement of storage stability by including the pantothenic acid derivative and / or salt thereof, etc. It was found that a cosmetic or an external preparation for skin in which improvement in performance as a pharmaceutical preparation was achieved was obtained.

  That is, the present invention is a cosmetic or skin external preparation containing a pantothenic acid derivative represented by the following general formula (1) and / or a salt thereof, and an effect promoter.

(In General Formula (1), R ¹ and R ² are each independently a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, and bonded to the carbonyl carbon of the acyl group. The hydrocarbon group is a saturated or unsaturated hydrocarbon group, and at least one of R ¹ and R ² is the acyl group.)

  In the cosmetic or the external preparation for skin, the pantothenic acid derivative represented by the general formula (1) and / or a salt thereof is a pantothenic acid derivative represented by the following formula (1) -301 or (1) -302: And / or a salt thereof.

  In the cosmetic or the external preparation for skin, the salt of the pantothenic acid derivative is a salt formed with the inorganic anion or organic anion as the pantothenic acid derivative as a cation, or an inorganic cation or a salt as the pantothenic acid derivative as an anion. A salt formed with an organic cation is preferred.

  In the cosmetic or the external preparation for skin, the salt of the pantothenic acid derivative is composed of nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halogen ion, formate ion, acetate ion, citric acid. Acid ion, tartrate ion, oxalate ion, fumarate ion, anion of saturated or unsaturated chain fatty acid having 3 to 20 carbon atoms, anion of carnitine and its derivative, anion of hydroxycitrate and its derivative, anion of ascorbic acid And a salt formed with one or more anions selected from the group consisting of anions of ascorbyl phosphate and derivatives thereof.

  In the cosmetic or the external preparation for skin, the salt of the pantothenic acid derivative is a sodium ion, a potassium ion, a calcium ion, a magnesium ion, a zinc ion, an ammonium ion, a carnitine, or a carnitine derivative. It may be a salt formed with one or more cations selected from the group consisting of the above cations.

  According to the present invention, by containing the pantothenic acid derivative represented by the general formula (1) and / or a salt thereof and an effect accelerator, the human body by containing the pantothenic acid derivative and / or the salt thereof. It is possible to provide a cosmetic or an external preparation for skin in which improvement in performance as a preparation such as improvement of the effect and / or storage stability is achieved.

≪Cosmetics or topical skin preparations≫
The cosmetic or external preparation for skin of the present invention contains a pantothenic acid derivative represented by the following general formula (1) and / or a salt thereof, and an effect accelerator.

<Pantothenic acid derivative and / or salt thereof>
The pantothenic acid derivative and / or salt thereof used in the cosmetic or skin external preparation of the present embodiment is abbreviated as pantothenic acid derivative represented by the following general formula (1) (hereinafter referred to as “pantothenic acid derivative (1)”). And / or a salt thereof.

(In General Formula (1), R ¹ and R ² are each independently a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, and bonded to the carbonyl carbon of the acyl group. The hydrocarbon group is a saturated or unsaturated hydrocarbon group, and at least one of R ¹ and R ² is the acyl group.)

The pantothenic acid derivative (1) and salts thereof have higher absorbability in the body such as skin permeability than the conventional pantothenic acid, pantothenic acid derivatives and salts thereof. This is because the pantothenic acid derivative (1) and its salt have an acyl group having 11 to 30 carbon atoms, so that it has a fat-soluble part in addition to a water-soluble part and is amphiphilic. by. In addition, after the pantothenic acid derivative (1) and its salt are absorbed in the body, it is decomposed by a biological enzyme reaction to become pantothenic acid. Therefore, by using the pantothenic acid derivative (1) and a salt thereof, pantothenic acid can reach the skin tissue in a sufficient amount.
In the present specification, “derivative” means a compound in which one or more hydrogen atoms of the original compound are substituted with a group (substituent) other than a hydrogen atom.

In General Formula (1), R ¹ and R ² are each independently a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, and are bonded to the carbonyl carbon of the acyl group. The hydrocarbon group (hydrocarbyl group) is a saturated or unsaturated hydrocarbon group. In the acyl group, the saturated or unsaturated hydrocarbon group has 10 to 29 carbon atoms.

In the acyl group, the saturated hydrocarbon group (alkyl group) bonded to the carbonyl carbon has 10 to 29 carbon atoms, and may be either linear or branched.
Specific examples of the alkyl group include decyl group, undecyl group, dodecyl group, tridecyl group, tetradecyl group, pentadecyl group, hexadecyl group, heptadecyl group, octadecyl group, nonadecyl group, icosyl group, heicosyl group, docosyl group, tricosyl group. Group, tetracosyl group, pentacosyl group, hexacosyl group, heptacosyl group, octacosyl group, nonacosyl group, etc., a linear alkyl group having 10 to 29 carbon atoms, such as a hexylnonyl group, A branched alkyl group having the same carbon number as the alkyl group can be exemplified.

In the acyl group, the unsaturated hydrocarbon group bonded to the carbonyl carbon has 10 to 29 carbon atoms, and may be linear or branched.
Examples of the unsaturated hydrocarbon group include a double bond (C═C) or a triple bond (C≡) in which one or more single bonds (C—C) between carbon atoms of the alkyl group are unsaturated bonds. Examples thereof include a group substituted with C).
In the unsaturated hydrocarbon group, the number of unsaturated bonds may be one, or two or more. When the number of unsaturated bonds is 2 or more, these unsaturated bonds may be double bonds only, triple bonds only, or double bonds and triple bonds may be mixed.
In the unsaturated hydrocarbon group, the position of the unsaturated bond is not particularly limited.

The unsaturated hydrocarbon group preferably has 1 to 3 unsaturated bonds, and more preferably 1 or 2.
The unsaturated hydrocarbon group preferably has only a double bond as an unsaturated bond.
Particularly preferred examples of the unsaturated hydrocarbon group include a decenyl group, an undecenyl group, a dodecenyl group, a tridecenyl group, a tetradecenyl group, a pentadecenyl group, a hexadecenyl group, a heptadecenyl group, an octadecenyl group, a nonadecenyl group, an icosenyl group, a heicocosenyl group, and a dococenyl group. Group, tricosenyl group, tetracocenyl group, pentacocenyl group, hexacocenyl group, heptacocenyl group, octacocenyl group, nonacosenyl group, etc. A branched alkenyl group can be exemplified by a number.

Carbon number of the acyl group in R ¹ and R ² is preferably 11 to 25, more preferably 11 to 20, further preferably 14 to 20, and preferably 16 to 18. Particularly preferred. That is, the number of carbon atoms of the hydrocarbon group bonded to the carbonyl carbon of the acyl group is preferably 10-24, more preferably 10-19, still more preferably 13-19, It is especially preferable that it is 15-17.

  The hydrocarbon group bonded to the carbonyl carbon of the acyl group is preferably an alkyl group or an alkenyl group.

In general formula (1), at least one of R ¹ and R ² is the acyl group. That is, a compound represented by the following general formula (1) -1 in which both R ¹ and R ² are the acyl group (hereinafter sometimes abbreviated as “compound (1) -1”), R ¹ is A compound represented by the following general formula (1) -2, which is the acyl group and R ² is a hydrogen atom (hereinafter sometimes abbreviated as “compound (1) -2”), and R ¹ is a hydrogen atom. And a compound represented by the following general formula (1) -3 (hereinafter sometimes abbreviated as “compound (1) -3”), wherein R ² is the acyl group.

(In General Formulas (1) -1 to (1) -3, R ¹¹ and R ²¹ are each independently a linear or branched C10-29 saturated or unsaturated hydrocarbon group. In general formula (1) -2, R ¹¹ is a linear or branched saturated or unsaturated hydrocarbon group having 10 to 29 carbon atoms, and in general formula (1) -3, R ^21. Is a linear or branched C10-29 saturated or unsaturated hydrocarbon group.)

R ¹¹ and R ²¹ are each independently a linear or branched saturated or unsaturated hydrocarbon group (hydrocarbyl group) having 10 to 29 carbon atoms, and the acyl group in R ¹ and R ² described above It is the same as the hydrocarbon group bonded to the carbonyl carbon.

  The salt of the pantothenic acid derivative (1) may be a salt formed by two or more molecules of a molecule derived from the pantothenic acid derivative (1) and another molecule, or derived from the pantothenic acid derivative (1). An inner salt in which a single molecule forms a salt may be used.

  Among the salts of the pantothenic acid derivative (1), those that form a salt with two or more molecules described above have a structure in which the pantothenic acid derivative (1) reacts with an acid or a base to form a salt. There is no particular limitation. Such salts include salts formed with pantothenic acid derivatives (1) as cations and anions (inorganic or organic anions), and cations (inorganic or organic cations) with pantothenic acid derivatives (1) as anions. ) And any salt formed with it.

Examples of the site (group) that can be a cation moiety in the pantothenic acid derivative (1) include a group represented by the formula “—NH—”. Examples of the salt of the pantothenic acid derivative (1) include the pantothenic acid derivative (1). A group represented by the formula “—NH—” becomes a monovalent cation moiety, and a salt formed by this cation moiety and an anion can be exemplified. Here, examples of the cation moiety include those in which a hydrogen ion (H ⁺ ) is coordinated to a nitrogen atom of a group represented by the formula “—NH—” (—NH ₂ ⁺ −). In this case, the valence of the anion is not particularly limited, and may be 1 (monovalent) or 2 (divalent) or more. When the anion is monovalent, the number of the anion forming the salt of the pantothenic acid derivative (1) and the number of cations derived from the pantothenic acid derivative (1) are both 1. When the anion is n-valent (n is an integer of 2 or more), the number of the anions forming the salt of the pantothenic acid derivative (1) is usually 1, and the pantothenic acid derivative (1) The number of derived cations is n or less, and preferably n. In this case, all of the plurality of cations may be the same, all may be different, or only a part may be the same.

On the other hand, examples of the site (group) that can be an anion moiety in the pantothenic acid derivative (1) include a carboxy group (—C (═O) —OH), and examples of the salt of the pantothenic acid derivative (1) include (1) carboxy group anion (-C (= O) -O ^-) of a, salts formed with the anion portion and a cation can be exemplified. The valence of the cation in this case is not particularly limited, and may be 1 (monovalent) or 2 (divalent) or more. When the cation is monovalent, the number of cations forming the salt of the pantothenic acid derivative (1) and the number of anions derived from the pantothenic acid derivative (1) are both 1. When the cation is m-valent (m is an integer of 2 or more), the number of cations forming the salt of the pantothenic acid derivative (1) is usually 1, and the pantothenic acid derivative (1) The number of derived anions is m or less, preferably m.

As described above, the cation and the anion constituting the salt of the pantothenic acid derivative (1) of one molecule may be either one, two or more, and when there are two or more, these cations or anions May all be the same, may all be different, or may be partially the same.
However, the salt of the pantothenic acid derivative (1) is electrically neutral as a whole molecule, that is, the total value of the cation valence and the total value of the anion valence in one molecule of the pantothenic acid derivative (1) Preferably they are the same.

The said anion which forms the salt of a pantothenic acid derivative (1) with what the pantothenic acid derivative (1) became a cation is not specifically limited.
Among the anions, preferred inorganic anions include nitrate ions, sulfate ions, carbonate ions, hydrogen carbonate ions, halogen ions, and the like. Examples of the halogen ions include fluoride ions, chloride ions, bromide ions, iodides. An ion etc. can be illustrated.

  Among the anions, preferred organic anions include anions of carboxylic acid, anions of carnitine and derivatives thereof, anions of hydroxycitric acid and derivatives thereof, anions of ascorbic acid, anions of ascorbyl phosphate and derivatives thereof, and the like.

The anion of the carboxylic acid may be an anion of a monocarboxylic acid (monovalent carboxylic acid) or an anion of a polyvalent carboxylic acid such as a dicarboxylic acid or a tricarboxylic acid.
Examples of the carboxylic acid anion include formate ion; acetate ion; propanoic acid (propionic acid) ion, butanoic acid (butyric acid) ion, pentanoic acid (valeric acid) ion, hexanoic acid (caproic acid) ion, heptanoic acid (enanthic acid) ) Ion, octanoic acid (caprylic acid) ion, nonanoic acid (pelargonic acid) ion, decanoic acid (capric acid) ion, dodecanoic acid (lauric acid) ion, tetradecanoic acid (myristic acid) ion, pentadecanoic acid ion, hexadecanoic acid ion ( Palmitic acid) ion, heptadecanoic acid ion, octadecanoic acid (stearic acid) ion, eicosanoic acid (arachidic acid) ion, cis-9-octadecenoic acid (oleic acid) ion, cis, cis-9,12-octadecadienoic acid ( Linoleic acid) ion, cis, cis, cis- , 12,15-octadecatrienoic acid (α-linolenic acid) ion, all-cis-6,9,12-octadecatrienoic acid (γ-linolenic acid) ion, (5Z, 8Z, 11Z, 14Z) -icosa Anion of saturated or unsaturated chain fatty acid having 3 or more carbon atoms such as 5,8,11,14-tetraenoic acid (arachidonic acid) ion; oxalate ion, malonate ion, succinate ion, glutarate ion, adipine Examples include anions of saturated or unsaturated dicarboxylic acids having 2 or more carbon atoms such as acid ions, fumarate ions and maleate ions; anions of hydroxy acids such as citrate ions, tartaric acid ions and hydroxycitrate ions.
In the present specification, the “fatty acid” means a monocarboxylic acid having a chain structure unless otherwise specified.

The above-mentioned anion of a saturated or unsaturated chain fatty acid having 3 or more carbon atoms preferably has 3 to 25 carbon atoms, and more preferably 3 to 20 carbon atoms. Moreover, the anion of the unsaturated chain fatty acid having 3 or more carbon atoms preferably has 1 to 4 unsaturated bonds (double bonds between carbon atoms).
The above-mentioned anion of a saturated or unsaturated dicarboxylic acid having 2 or more carbon atoms preferably has 2 to 6 carbon atoms, and more preferably 2 to 4 carbon atoms. In addition, the anion of an unsaturated dicarboxylic acid having 2 or more carbon atoms preferably has one unsaturated bond (double bond between carbon atoms).
In the anion of a saturated or unsaturated chain fatty acid having 3 or more carbon atoms and the anion of a saturated or unsaturated dicarboxylic acid having 2 or more carbon atoms, those having a carbon number in the above numerical range, and the number of unsaturated bonds Those within the range have advantages such as easy acquisition of raw materials and easy production.

  The anion that forms a salt of the pantothenic acid derivative (1) together with the one obtained by converting the pantothenic acid derivative (1) into a cation is nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halogen ion, formate ion, acetate ion, Citrate ion, tartrate ion, oxalate ion, fumarate ion, anion of saturated or unsaturated chain fatty acid having 3 to 20 carbon atoms, anion of carnitine and its derivative, anion of hydroxycitrate and its derivative, ascorbic acid An anion and one or more anions selected from the group consisting of an anion of ascorbyl phosphate and its derivatives are preferable.

The said cation which forms the salt of a pantothenic acid derivative (1) with what the pantothenic acid derivative (1) became an anion is not specifically limited.
Among the cations, preferred inorganic cations include sodium ion, potassium ion, calcium ion, magnesium ion, lithium ion, barium ion, aluminum ion, zinc ion, copper ion (Cu ⁺ , Cu ²⁺ ), iron ion (Fe ²⁺ ). Fe ³⁺ ), manganese ions, nickel ions, tin ions (Sn ²⁺ , Sn ⁴⁺ ), ammonium ions, and the like.
Among the cations, preferable organic cations include carnitine and cations of carnitine derivatives.

  The cation that forms the salt of the pantothenic acid derivative (1) together with the anion of the pantothenic acid derivative (1) is sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine, and carnitine. One or more cations selected from the group consisting of cations of derivatives are preferred.

Among the salts of the pantothenic acid derivative (1), the intramolecular salt is an anion moiety (—C (═O) — in which the carboxy group (—C (═O) —OH) is dissociated in the pantothenic acid derivative (1)). O ⁻ ), and a proton is added to the group represented by the formula “—NH—” to form a cation moiety represented by the formula “—NH ₂ ⁺ —”.

  As a preferable salt of the pantothenic acid derivative (1), the pantothenic acid derivative (1) becomes a cation to form nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halogen ion, formate ion, acetate ion, citric acid. Ions, tartaric acid ions, oxalate ions, fumarate ions, anions of saturated or unsaturated chain fatty acids having 3 to 20 carbon atoms, anions of carnitine and its derivatives, anions of hydroxycitrate and its derivatives, anions of ascorbic acid, And salts formed with one or more anions selected from the group consisting of anions of ascorbyl phosphate and derivatives thereof.

  Moreover, as a preferable thing of the salt of pantothenic acid derivative (1), pantothenic acid derivative (1) becomes an anion, and sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine, and carnitine Examples thereof include salts formed with one or more cations selected from the group consisting of cations of derivatives.

  The pantothenic acid derivative (1) has a plurality of stereoisomers such as an asymmetric atom in the molecule. That is, all these stereoisomers are included in the pantothenic acid derivative (1) and its salt.

The pantothenic acid derivative (1) and the salt thereof have moderate fat solubility due to the number of carbon atoms of the acyl group of R ¹ and R ² being 11 or more. When used as a component of an external preparation described later, the amount of pantothenic acid reaching the skin tissue is significantly higher than that of a salt (for example, a carboxy group forming a salt). For example, a compound in which at least one of R ¹¹ and R ²¹ in the general formula (1) -1 is a saturated or unsaturated hydrocarbon group having 1 to 9 carbon atoms, the general formula (1) -2 or (1 ) -3 wherein R ¹¹ or R ²¹ is a saturated or unsaturated hydrocarbon group having 1 to 9 carbon atoms, or a salt of these compounds, the pantothenic acid derivative (1) and its salt are Even if it is the same in terms of the acylated product of the hydroxyl group, the amount of pantothenic acid reaching the skin tissue is remarkably high when used as a component of an external preparation described later. Therefore, the pantothenic acid derivative (1) or a salt thereof is remarkably excellent in the effect of improving pantothenic acid deficiency symptoms.
The pantothenic acid derivative (1) and a salt thereof are useful as active ingredients for external preparations for skin and cosmetics, and are also useful as active ingredients for food additives due to their high absorbability in the body.

In addition, the pantothenic acid derivative (1) and its salt have moderate water-solubility because the carbon number of the acyl group is 30 or less (the carbon number of the hydrocarbon group in the acyl group is 29 or less). . Thereby, for example, a compound in which at least one of R ¹¹ and R ²¹ in the general formula (1) -1 is a saturated or unsaturated hydrocarbon group having 30 or more carbon atoms, the general formula (1) -2 or In comparison with a compound in which R ¹¹ or R ²¹ in (1) -3 is a saturated or unsaturated hydrocarbon group having 30 or more carbon atoms, or a salt of these compounds, the pantothenic acid derivative (1) and its salt are When used as a component of an external preparation described later, blending into the external preparation is easy and excellent in handleability.

<Method for producing pantothenic acid derivative (1)>
The pantothenic acid derivative (1) can be produced, for example, by two methods, Method 1 and Method 2 shown below.
Method 1 includes a compound represented by the following general formula (1a) (hereinafter sometimes abbreviated as “compound (1a)”) and a compound represented by the following general formula (1b ¹ ) (hereinafter “compound”). (1b ¹⁾ "and is sometimes abbreviated) and by reacting the following general formula ⁽¹ 01) a compound represented by -1 (hereinafter," compound ⁽¹ 01) may be abbreviated -1 " ), A compound represented by the following general formula (1 ⁰¹ ) -2 (hereinafter sometimes abbreviated as “compound (1 ⁰¹ ) -2”) and a compound represented by the following general formula (1 ⁰¹ ) -3 (hereinafter, "compound (1 ⁰¹⁾ -3 'and it may be abbreviated) obtaining one or more compounds selected from the group consisting of (hereinafter, to be abbreviated as" compound (1 ⁰⁾ manufacturing process " Is a manufacturing method. Hereinafter, in this specification, the compound (1 ⁰¹ ) -1, the compound (1 ⁰¹ ) -2, and the compound (1 ⁰¹ ) -3 may be collectively referred to as “compound (1 ⁰ )”.

(Wherein R ⁰¹ is a linear or branched C10-C29 saturated or unsaturated hydrocarbon group; X is a leaving group; M is a cation with a valence of p. P is an integer of 1 or more.)

Method 1 is a method in which only one compound to be reacted with compound (1a) is used.
Among the compounds that may be obtained by Method 1, Compound (1 ⁰¹ ) -1 corresponds to a compound in which R ¹¹ and R ²¹ are the same among Compounds (1) -1. Compound (1 ⁰¹ ) -2 corresponds to compound (1) -2, and compound (1 ⁰¹ ) -3 corresponds to compound (1) -3.

Method 2 is abbreviated as a compound to be reacted with the compound (1a) in addition to the compound (1b ¹ ) and a compound represented by the following general formula (1b ² ) (hereinafter referred to as “compound (1b ² )”). Is different from Method 1. Method 2 is the same as Method 1 except for this point, and the compounds that may be obtained are the above-mentioned compound (1 ⁰¹ ) -1, compound (1 ⁰¹ ) -2, and compound (1 ⁰¹ ) -3. In addition, a compound represented by the following general formula (1 ⁰² ) -1 (hereinafter sometimes abbreviated as “compound (1 ⁰² ) -1”), represented by the following general formula (1 ⁰² ) -2 Compound (hereinafter sometimes abbreviated as “compound (1 ⁰² ) -2”), a compound represented by the following general formula (1 ⁰² ) -3 (hereinafter referred to as “compound (1 ⁰² ) -3”) May be abbreviated), a compound represented by the following general formula (1 ⁰³ ) -1 (hereinafter sometimes abbreviated as “compound (1 ⁰³ ) -1”), and the following general formula (1 ⁰³ ) -2. compound represented by it is (hereinafter, "compound (1 ⁰³⁾ -2" may be abbreviated as)

That is, in Method 2, compound (1a) is reacted with either one or both of compound (1b ¹ ) and compound (1b ² ) to give compound (1 ⁰¹ ) -1 and compound (1 ⁰¹ ) -2. , Compound (1 ⁰¹ ) -3, Compound (1 ⁰² ) -1, Compound (1 ⁰² ) -2, Compound (1 ⁰² ) -3, Compound (1 ⁰³ ) -1 and Compound (1 ⁰³ ) -2 It is a production method having a step of obtaining one or more compounds selected from the group (hereinafter, sometimes abbreviated as “compound (1 ⁰ ) production step” as in the case of Method 1).
Hereinafter, in the present specification, in the same manner as in the compound (1 ⁰¹ ) -1, the compound (1 ⁰¹ ) -2 and the compound (1 ⁰¹ ) -3, the compound (1 ⁰² ) -1, the compound (1 ⁰² ) -2 , Compound (1 ⁰² ) -3, Compound (1 ⁰³ ) -1 and Compound (1 ⁰³ ) -2 may be collectively referred to as “Compound (1 ⁰ )”. In addition, the compound (1b ¹ ) and the compound (1b ² ) may be collectively referred to as “compound (1b)”.

^{(Wherein, R 02} is a saturated or unsaturated hydrocarbon group of 10 to 29 carbon atoms linear or ^branched, different from each other and ^{R 01; R 01, X,} M and p are as above Same.)

R ⁰¹ and R ⁰² are not the same, and method 2 is a method using two types of compounds to be reacted with compound (1a).
Among the above compounds that may be obtained by Method 2, Compound (1 ⁰¹ ) -1 and Compound (1 ⁰² ) -1 are identical in R ¹¹ and R ²¹ among Compound (1) -1. Corresponds to the compound. In addition, compound (1 ⁰³ ) -1 and compound (1 ⁰³ ) -2 correspond to compounds in which R ¹¹ and R ²¹ are different from each other in compound (1) -1. Compound (1 ⁰¹ ) -2 and compound (1 ⁰² ) -2 correspond to compound (1) -2, and compound (1 ⁰¹ ) -3 and compound (1 ⁰² ) -3 correspond to compound (1). -3.

Thus, the compound (1 ⁰ ) is the same as the pantothenic acid derivative (1), and here, for the sake of convenience, these are represented separately.

  Method 1 and method 2 are the same except that the number of types of compounds to be reacted with compound (1a) is different. This will be described in more detail below.

In the compound (1 ⁰ ) production process in method 1 and method 2, acylation reaction of a hydroxyl group is performed by reacting compound (1a) with compound (1b).
Compound (1a) forms a salt with M in which the carboxylate anion is a cation.
In the formula, M is a cation having a valence of p, and p is an integer of 1 or more.
As M, the same thing as the cation which forms a salt with the thing which pantothenic acid derivative (1) became anion demonstrated previously can be illustrated, and it is preferable that it is an inorganic cation.
p is preferably 1 or 2.

Compound (1b) (compound (1b ¹ ) and compound (1b ² )) is an acylating agent.
In the formula, R ⁰¹ and R ⁰² are linear or branched saturated or unsaturated hydrocarbon groups having 10 to 29 carbon atoms, and in the general formulas (1) -1 to (1) -3 R ¹¹ and R ²¹ are the same. However, R ⁰¹ and R ⁰² are different from each other.
In the formula, X is a leaving group. The leaving group may be a known one, and preferable examples include halogen atoms such as chlorine atom and bromine atom; alkoxy groups such as methoxy group; alkylcarbonyloxy groups such as methylcarbonyloxy group. In the compound (1b ¹ ) and the compound (1b ² ), X may be the same or different.
The amount of compound (1b) used (in the case of method 2, the total amount of compound (1b ¹ ) and compound (1b ² )) is not particularly limited, and is appropriately determined according to the type of target compound (1 ⁰ ). It is preferable to adjust. In the case of method 2, the ratio of the amount of the compound (1b ¹⁾ and compound (1b ²⁾ it may appropriately be adjusted according to the type of the target compound (1 ^0).

In the reaction of the compound (1 ⁰ ) production process in Method 1 and Method 2, compound (1a) may be used alone, in combination of two or more, or in combination of two or more. The combination and ratio can be arbitrarily selected.
In this step, the compound (1 ⁰ ) obtained is usually the same combination no matter how many types of compound (1a) are used. Therefore, it is usually sufficient to use one compound (1a). However, as will be described later, when the compound (1 ⁰ ) is taken out as its salt after this step, the combination of the salt of the compound (1 ⁰ ) obtained can be changed depending on how many kinds of the compound (1 a) are used. There is sex.
In addition, although the case where two types of compounds (1b) (compound (1b ¹ ) and compound (1b ² )) were used in combination as Method 2 was described here, if necessary, three or more types of compounds (1b) were used in combination. May be.

The reaction in the step of producing compound (1 ⁰ ) in Method 1 and Method 2 is preferably performed using a solvent.
The solvent is not particularly limited as long as it does not hinder the reaction, and examples thereof include ethers (compounds having an ether bond) such as tetrahydrofuran (THF), 1,4-dioxane, diethyl ether, and dibutyl ether.
A solvent may be used individually by 1 type, may use 2 or more types together, may be used as a mixed solvent, and when using 2 or more types together, the combination and ratio can be suitably selected according to the objective.
The amount of the solvent used is not particularly limited and may be appropriately selected in consideration of the solubility of the raw materials used, the stirring property of the reaction solution, and the like. For example, the concentration of the compound (1a) at the start of the reaction is 10 to 10. The amount used can be 200 mM.

The reaction in the step of producing compound (1 ⁰ ) in Method 1 and Method 2 is preferably performed using a base.
The base may be either an inorganic base or an organic base, and can be appropriately selected according to the purpose, but is preferably an organic base.
Examples of the inorganic base include lithium hydroxide, sodium hydroxide, potassium hydroxide, calcium hydroxide, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate and the like.
Examples of the organic base include pyridine, triethylamine, and ethyldiisopropylamine.
A base may be used individually by 1 type, may use 2 or more types together, and when using 2 or more types together, the combination and ratio can be suitably selected according to the objective.
The amount of the base is not particularly limited, (in the case of method 2, Compound (1b ¹⁾ and compound (total amount of 1b ²⁾⁾ The amount of the compound (1b) with respect to 6-fold molar The amount is preferably 1 to 4 times the molar amount.

The reaction in the step of producing compound (1 ⁰ ) in Method 1 and Method 2 may be performed using a catalyst.
The catalyst is not particularly limited, and can be appropriately selected according to the purpose. Preferred examples include 4-dimethylaminopyridine (DMAP).
A catalyst may be used individually by 1 type, may use 2 or more types together, and when using 2 or more types together, the combination and ratio can be suitably selected according to the objective, Usually 1 type Only is enough.
The amount of the catalyst used is not particularly limited, but is 0.01 to 0 with respect to the amount of compound (1b) used (in the case of Method 2, the total amount of compound (1b ¹ ) and compound (1b ² )). The molar amount is preferably 3 times, more preferably 0.01 to 0.1 times the molar amount.

The reaction conditions in the production process of the compound (1 ⁰ ) in Method 1 and Method 2 are preferably adjusted as appropriate so that the reaction proceeds well. However, usually, the reaction temperature is preferably 15 to 80 ° C, and more preferably 20 to 60 ° C. The reaction time is preferably 0.5 to 36 hours, and more preferably 0.5 to 24 hours.

In the production step of compound (1 ⁰ ) in method 1 and method 2, after completion of the reaction, if necessary, post-treatment can be performed by a known method, and the target compound (1 ⁰ ) can be taken out by a known method. . That is, after the reaction is completed, post-treatment operations such as filtration, washing, extraction, pH adjustment, dehydration, concentration, etc. are performed alone or in combination of two or more, as necessary, and concentrated, crystallized, and reprecipitated. The compound (1 ⁰ ) can be taken out by column chromatography or the like. In addition, the extracted compound (1 ⁰ ) is further subjected to operations such as crystallization, reprecipitation, column chromatography, extraction, and stirring and washing of crystals with a solvent, if necessary, or in combination of two or more. You may refine | purify by performing once or more.
The compound (1 ⁰ ) may be used for the intended purpose without being taken out after being subjected to post-treatment as necessary after completion of the reaction.
Compound (1 ⁰ ) can be easily obtained, for example, by placing it under acidic conditions in the step immediately before taking out the obtained reaction product or immediately before use for the intended use.

The obtained compound (1 ⁰ ) is, for example, nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS), infrared spectroscopy (IR), ultraviolet / visible spectroscopy (UV-VIS absorption spectrum), etc. The structure can be confirmed by a known method.

As compound (1a) and compound (1b), either commercially available products may be used, or those produced according to known methods may be used.
For example, the compound (1a) is obtained by reacting a compound in which R ¹ and R ² are both substituted with hydrogen atoms in the pantothenic acid derivative (1) with a hydroxide formed with M and hydroxide ions. can get. After completion of the reaction, the compound (1 ⁰ ) production step is carried out by taking out the compound (1a) in the same manner as in the case of the compound (1 ⁰ ) or without taking it out in the state of a solution or dispersion of the compound (1a). Can be used.

In the above production method, two or more compounds can be formed as the compound (1 ⁰ ) during the reaction.
Therefore, when a mixture of these compounds (1 ⁰ ) is produced by the reaction, for example, the target compound (1 ⁰ ) can be separated by applying the above purification method one or more times.

In the production method described above, it is possible to improve the production rate of any of the two or more compounds (1 ⁰ ) by adjusting the reaction conditions.
Of the two hydroxyl groups in the compound (1a) to be reacted, the hydroxyl group present at the end of the molecule is more reactive in this step than the hydroxyl group bonded to the carbon atom adjacent to the carbonyl group. . Therefore, in general, the compound (1 ⁰¹ ) -3 and the compound (1 ⁰² ) -3 are most easily generated under the same reaction conditions, and the compound (1 ⁰¹ ) -2 and the compound ( 1 ⁰² ) -2, and the most difficult to produce are Compound (1 ⁰¹ ) -1, Compound (1 ⁰² ) -1, Compound (1 ⁰³ ) -1 and Compound (1 ⁰³ ) -2. Therefore, it is possible to improve the yield of the target compound (1 ⁰ ) by adjusting the reaction conditions in consideration of this difference in reactivity.

For example, in the case of the method 1, compound (1 ⁰¹ ) -1 is used in an amount of compound (1b) with respect to the amount of hydroxyl group in compound (1a), preferably 2 to 6 times, more preferably 3 to 5. By increasing the amount of compound (1b) used as a double molar amount, the production rate and yield can be improved.
In the case of method 1, compound (1 ⁰¹ ) -2 and compound (1 ⁰¹ ) -3 are used in an amount of compound (1b) with respect to the amount of hydroxyl group in compound (1a), preferably 1 to 3 times mol. The production rate and the yield can be improved by reducing the amount of the compound (1b) used, more preferably 1.5 to 2.5 times the molar amount.
Similarly, in the case of Method 2, the amount of compound (1b) used (total amount of compound (1b ¹ ) and compound (1b ² )) is adjusted, or compound (1b ¹ ) and compound (1b ^2). ) Can be adjusted to improve the production rate and yield of the specific compound (1 ⁰ ).

<Method for Producing Compound Salt>
The salt of pantothenic acid derivative (1) can be obtained, for example, by treating the reaction product immediately before removal with an excess amount of acid or base in the above-described method for producing pantothenic acid derivative (1) (compound (1 ⁰ )). Can be manufactured.
The salt of pantothenic acid derivative (1) can also be produced by treating the taken pantothenic acid derivative (1) (compound (1 ⁰ )) with an excess amount of acid or base.
In any case, the salt of pantothenic acid derivative (1) can be taken out in the same manner as in the case of pantothenic acid derivative (1).

In the cosmetic or external preparation for skin of the present invention, the pantothenic acid derivative (1) and the salt of the pantothenic acid derivative (1) can be used alone or in combination. When a mixture of a plurality of compounds is used as the pantothenic acid derivative (1) and / or a salt thereof, each compound in the mixture can be blended in an arbitrary ratio.
The pantothenic acid derivative (1) and / or a salt thereof is preferably contained in an amount of 0.01% by mass to 20% by mass, and 0.05% by mass to 12% by mass in the total amount of the external preparation for skin. Is more preferable, and 0.1 to 10% by mass is more preferable. When the pantothenic acid derivative (1) and / or a salt thereof is contained in the above-mentioned content, the transfer to the skin is quick and the efficacy required for the cosmetic or the external preparation for skin can be effectively exhibited.

<Effect promoter>
The effect promoter used in the cosmetic or external preparation for skin of the present invention is an oily base, a moisturizer, a touch improver, a surfactant, a polymer, a thickening / gelling agent, a solvent, a propellant, an antioxidant. , Reducing agents, oxidizing agents, antiseptics, antibacterial agents, chelating agents, pH adjusting agents, acids, alkalis, powders, inorganic salts, UV absorbers, whitening agents, vitamins and their derivatives, anti-inflammatory agents, anti-inflammatory agents Hair growth agent, blood circulation promoter, stimulant, hormones, anti-wrinkle agent, anti-aging agent, anti-aging agent, cooling sensation agent, warming sensation agent, wound healing promoter, irritation relaxation agent, analgesic agent, cell activator, Plant / animal / microbe extract, antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, pigment, water, metal-containing compound, unsaturated monoton Polymer, polyhydric alcohol, polymer additive, anti-inflammatory analgesic, antifungal, antihistamine, Sedatives, tranquilizers, antihypertensives, antihypertensive diuretics, antibiotics, anesthetics, antibacterial substances, antiepileptics, coronary vasodilators, herbal medicines, adjuvants, wetting agents, astringents, thickeners, adhesives 1 selected from an imparting substance, antipruritic agent, keratin softening release agent, oily raw material, ultraviolet ray blocking agent, antiseptic disinfectant, antioxidant substance, liquid matrix, fat-soluble substance, polymeric carboxylate, additive, metal soap It is a seed or two or more kinds.

  The cosmetic or skin external preparation of the present invention is a synergistic combination of the pantothenic acid derivative represented by the above general formula (1) and / or a salt thereof and one or more selected from the above effect promoters. The effect can improve the effect on the human body as a cosmetic and / or external skin preparation resulting from the pantothenic acid derivative (1) and / or its salt, and the performance as a cosmetic and external skin preparation.

  In addition, the cosmetic or skin external preparation of the present invention is prepared by adding the raw materials described in the existing raw material standard or official document to a general concentration, for example, preferably the total amount of the cosmetic or skin external preparation of the present invention. It can also be added at 100 ppm to 90% by weight. Examples of the raw materials described in the above-mentioned existing raw material standards or official documents include, for example, the 14th revised Japanese Pharmacopoeia, edited by the Japan Standards Association, issued by Jiho Co., Ltd., issued in April 2001. Commentary on the second edition of the standards, edited by the Japanese Official Church, 1984 (Pharmaceutical Daily Report), Standards for Ingredients for Cosmetic Ingredients, Supervised by the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, 1993 (Pharmaceutical Daily Report), Supplement for Standards for Ingredients for Cosmetic Ingredients, Ministry of Health and Welfare Supervised by the Pharmaceutical Affairs Bureau Examination Division, 1993 (Pharmaceutical Daily Report), Permit Standards for Cosmetic Varieties, Supervision by the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, 1993 (Pharmaceutical Daily Report), and International Cosmetic Ingredient Dictionary 2002 Ninth Edition Vol. All raw materials described in 1-4, by CTFA, cosmetic raw material dictionary 1991 (Nikko Chemicals), etc. can be used.

The following examples are described as preferred examples of the formulation of cosmetics or external preparations for skin.
% In the formulation examples means mass%. The “pantothenic acid derivative” in the formulation examples is a pantothenic acid derivative represented by the above formula (1) -301. In each formulation example, instead of the pantothenic acid derivative represented by the formula (1) -301, a sodium salt of the pantothenic acid derivative represented by the formula (1) -301, represented by the formula (1) -302 Any one selected from the pantothenic acid derivatives represented by formula (1) -302 and the sodium salt of the pantothenic acid derivative represented by formula (1) -302 may be used. 2 selected from sodium salt of pantothenic acid derivative represented by (1) -301, pantothenic acid derivative represented by formula (1) -302, and sodium salt of pantothenic acid derivative represented by formula (1) -302 You may use the mixture which mix | blended the compound of the seed | species or more in arbitrary ratios.

Each composition of the formulation examples 1-7 was obtained by mixing all the components described in each formulation example and stirring at room temperature with a homomixer.
[Example 1]
Preparation of cream (Formulation Example 1)
Pantothenic acid derivative 0.5%
Cetanol 8.0%
Myristyl alcohol 7.0%
Glycerin 5.0%
Dextrin palmitate 0.5%
Polyglyceryl stearate-10 0.5%
POE (20) POP (4) Cetyl ether 0.5%
Xanthan gum 0.1%
Tocopherol 0.1%
Tocopherol acetate 0.1%
Methylparaben 0.1%
EDTA4Na 0.1%
Sodium hydroxide 0.1%
Octyl methoxycinnamate 0.1%
Arbutin 0.5%
Ascorbic acid tetraisopalmitate 0.5%
Glycyrrhizic acid 0.1%
Water 76.2%
Total 100.0%

(Prescription example 2)
Pantothenic acid derivative 0.5%
Cetostearyl alcohol 7.0%
Behenyl alcohol 8.0%
Propylene glycol 5.0%
Polyglyceryl isostearate-10 1.0%
Propylene glycol monostearate 1.0%
Gypsophila extract 0.1%
α-Tocopheryl phosphate 0.1%
Sodium γ-tocopheryl phosphate 0.1%
Propylparaben 0.1%
Penteto acid 5Na 0.1%
Potassium hydroxide 0.1%
Dimethyl PABA octyl 0.1%
Ascorbic acid glucoside 1.0%
Kojic acid 1.0%
Retinol 0.1%
Stearyl glycyrrhetinate 0.1%
Astaxanthin 0.1%
Purified water 74.5%
Total 100.0%

(Prescription Example 3)
Pantothenic acid derivative 0.5%
Octyldodecanol 5.0%
Stearic acid 5.0%
Squalane 5.0%
1,3-butylene glycol 5.0%
Glyceryl stearate 0.5%
PEG-24 glyceryl stearate 0.5%
PPG-decyltetradeces-30 1.0%
Hydroxyethyl cellulose 0.1%
α-Tocopheryl dimethyl glycinate 0.1%
γ-Tocopheryl dimethyl glycinate 0.1%
Phenoxyethanol 0.1%
Etidronic acid 4Na 0.1%
Arginine 0.1%
t-Butylmethoxydibenzoylmethane 0.1%
Ellagic acid 1.0%
Tranexamic acid 1.0%
Hesperidin 0.1%
Purified water 74.7%
Total 100.0%

(Prescription Example 4)
Pantothenic acid derivative 0.5%
Octyldodecyl myristate 7.0%
Isononyl isononanoate 8.0%
Hyaluronic acid Na 5.0%
PEG / PPG-25 / 30 copolymer 0.5%
Lauramidopropylbetaine 0.5%
Lauryl betaine 0.5%
Carboxyvinyl polymer 0.1%
Ascorbic acid 0.1%
Ascorbyl phosphate Na 0.1%
Ascorbyl phosphate Mg 0.1%
1,2-hexanediol 0.1%
Cetyl tranexamate 0.5%
Lucinol 0.5%
Retinol palmitate 0.1%
Purified water 76.5%
Total 100.0%

(Prescription Example 5)
Pantothenic acid derivative 0.5%
Isopropyl palmitate 5.0%
Dimethicone 5.0%
Cyclomethicone 5.0%
Ceramide 5.0%
Sorbitan sesquioleate 0.5%
PEN4630 0.5%
PBC-34 0.5%
Pluronic L64 0.5%
Carbopol 0.1%
pNVA 0.1%
Ascorbyl palmitate 3Na 0.1%
Coenzyme Q10 0.1%
Coenzyme Q10 phosphate 0.1%
1,2-pentanediol 0.1%
Ethylenediaminetetramethylenephosphonic acid 5Na 0.1%
AMP 0.5%
Linoleic acid v 0.5%
Placenta extract 0.5%
Methyl hesperidin 0.1%
Glycosyl hesperidin 0.1%
Purified water 75.1%
Total 100.0%

[Example 2]
Lotion adjustment (Formulation Example 6)
Pantothenic acid derivative 0.5%
Glycerin 4.0%
PG 6.0%
Ethanol 3.0%
Phenoxyethanol 0.1%
Phosphate 2K salt 3.5%
EDTA4Na 0.2%
PEG (50) hydrogenated castor oil 0.5%
Purified water 80.7%
Total 100.0%

[Example 3]
Sunscreen preparation (Prescription Example 7)
Pantothenic acid derivative 0.5%
Cyclomethicone 14.5%
Diphenyl dimethicone 7.0%
Isononyl isononanoate 5.0%
Trimethylsiloxysilicate 2.0%
Cyclopentasiloxane 3.0%
PEG-10 Dimethicone 2.0%
Sorbitan sesquioleate 2.0%
Stearyl glycyrrhetinate 0.02%
Tocopherol 0.02%
Zinc oxide powder 5.0%
Titanium oxide powder 10.0%
Na chloride 1.0%
Methylparaben 0.1%
Water 47.8%
Total 100.0%

[Example 4]
Preparation of lotion lotion was prepared according to the following formulation examples 8-11. In addition, in the prescription examples 8-11, the sum total of A component and B component was 100%.

(Prescription Example 8)
"A component"
Pantothenic acid derivative 0.5%
Dipotassium glycyrrhizinate 0.2%
Citric acid 0.1%
Sodium citrate 0.3%
Purified water residue “B component”
Polyoxyethylene sorbitol tetraoleate 0.9%
Sorbitan monooleate 0.1%
Olive oil 0.1%
Dipropylene glycol 5.0%
Methylparaben 0.1%
Ethanol 10.0%

(Prescription Example 9)
"A component"
Pantothenic acid derivative 0.5%
Sodium citrate 0.1%
Glycerin 8.0%
Sodium pyrrolidonecarboxylate 1.0%
Trehalose 0.03%
1,3-butylene glycol 5.0%
Purified water residue “B component”
Polyoxyethylene polyoxypropylene decyl tetradecyl ether 0.6%
Methylparaben 0.1%
Ethanol 10.0%

(Prescription Example 10)
"A component"
Pantothenic acid derivative 0.5%
Polyvinyl alcohol 0.1%
Carboxyvinyl polymer 0.2%
Glycerin 3.0%
Edetate trisodium 0.1%
Sodium hydroxide 0.05%
2-Amino-2-methyl-1-propanol 0.06%
Caffeine 0.1%
Purified water residue “B component”
Ethanol 20.0%
Polyoxyethylene oleyl ether 0.3%
Methylparaben 0.1%
Menthol 0.1%
In each of Formulation Examples 8, 9, and 10, the A component and the B component were mixed in advance and dissolved by heating at 50 ° C. Next, while stirring the A component, the B component was added little by little to the A component and solubilized. This was cooled with stirring, the stirring was stopped at 30 ° C., and left to stand to obtain each lotion.

(Prescription Example 11)
"A component"
1,3-butylene glycol 5.02%
Lauroyl glutamate di (cholesteryl / behenyl / octyldodecyl) 0.5%
Trehalose 0.03%
Trioctanoin 0.03%
PEG-58 hydrogenated castor oil 1.5% isostearic acid
PEG-60 hydrogenated castor oil 0.5%
Methylparaben 0.2%
Propylparaben 0.01%
Tocopherol 0.05%
"B component"
Pantothenic acid derivative 0.5%
Sodium malate 0.1%
Malic acid Appropriate amount of purified water

  A component and B component were mixed and dissolved by heating at 60 ° C. Next, while stirring the A component, the B component was mixed with the A component and cooled to obtain a uniform lotion.

[Example 5]
Preparation of Emulsion An emulsion was prepared according to the following formulation examples 12-14. In the prescription examples 12 to 13, the sum of the A component and the B component was 100%, and in the prescription example 14, the sum of the A to C components was 100%.

(Prescription Example 12)
"A component"
Squalane 10.0%
Polyoxyethylene glyceryl isostearate 3.5%
Polyoxyethylene hydrogenated castor oil triisostearate 6.5%
Pyroglutamic acid isostearate polyoxyethylene hydrogenated castor oil 12.0%
Methylparaben 0.1%
"B component"
Pantothenic acid derivative 0.5%
Purified water residue

  The A component and the B component were mixed, and the A component was dissolved by heating at 70 ° C. and the B component was heated at 50 ° C. Next, while stirring the A component, the B component was added little by little to the A component and emulsified. The resulting emulsion was cooled with stirring, and the resulting emulsion was diluted 10-fold with purified water to obtain an emulsion.

(Prescription Example 13)
"A component"
Liquid paraffin 10.6%
Isopropyl myristate 0.6%
Oleyl alcohol 1.2%
Polyoxyethylene stearyl ether 3.4%
PEG distearate 1.9%
Polyoxyethylene polyoxypropylene tetradecyl ether 0.4%
"B component"
Pantothenic acid derivative 0.5%
Sodium stearoyl glutamate 0.1%
Propylene glycol 1.4%
Methylparaben 0.1%
PEG-400 0.2%
Purified water residue

  The A component and the B component were respectively mixed in advance, and the A component was dissolved by heating at 70 ° C. and the B component was heated at 75 ° C. Next, while stirring the B component, the A component was added little by little to the B component and emulsified. This was cooled with stirring to obtain an emulsion.

(Prescription Example 14)
"A component"
Pantothenic acid derivative 0.5%
Polyoxyethylene sorbitan monostearate 1.0%
Tetraoleic acid polyoxyethylene sorbitol 0.5%
Sorbitan monostearate 1.0%
Stearic acid 0.5%
Behenyl alcohol 0.5%
Beeswax 0.5%
Squalane 10.0%
Glyceryl tri-2-ethylhexanoate 10.0%
Decaglyceryl dekaoleate 3.0%
1,3-butylene glycol 7.0%
Methylparaben 0.1%
"B component"
Xanthan gum 0.04%
Carboxy vinyl polymer 0.08%
Purified water residue “C component”
Triethanolamine 0.05%
Purified water 4.95%

  A component, B component, and C component were mixed, respectively, A component and B component were heated and dissolved at 80 ° C., and C component was homogenized at room temperature. Thereafter, while the A component was stirred, the B component was added to the A component to emulsify, and then the C component was added and cooled with stirring. As a result, an emulsion was formed at around 40 ° C. The emulsion composition was cooled to room temperature to obtain an emulsion.

[Example 6]
Preparation of gel Translucent gel was prepared according to the following formulation examples 15-20. In Formulation Example 15, the sum of A component and B component, in Formulation Example 16, the sum of A component to E component, and in Formulation Examples 17 to 20, the sum of A component to C component, respectively. 100%.

(Prescription Example 15)
"A component"
Agar 2.0%
Xanthan gum 0.2%
Caffeine 0.1%
Purified water 50.0%
"B component"
Pantothenic acid derivative 0.5%
Glycerin 7.0%
PEG-1500 8.0%
Methylparaben 0.1%
Purified water residue

  The A component and the B component were mixed, and the A component was heated and dispersed at 90 ° C. and the B component was heated at 50 ° C. Subsequently, the component A was cooled to 50 ° C. while stirring and the component B was added to the component A, and further cooled to 30 ° C. or less with stirring to cause gelation. When sufficiently hardened, the gel was broken using a disper to form a microgel, and then degassed to obtain a uniform gel (translucent gel).

(Prescription Example 16)
"A component"
Carboxy vinyl polymer 0.35%
Purified water 50.0%
"B component"
Sodium hydroxide 0.1%
Purified water 10.0%
"C component"
Pantothenic acid derivative 0.5%
Sodium hyaluronate 1% aqueous solution 6.0%
Purified water residue “D component”
Polyoxyethylene polyoxypropylene tetradecyl ether 0.3%
Ethanol 5.0%
Methylparaben 0.1%
"E component"
Perfluoropolyether 0.2%

  A component, B component, C component, and D component were mixed, A component and B component were dissolved at room temperature, C component was dissolved at 50 ° C., and D component was heated and dissolved at 40 ° C. Next, while stirring the A component, the B component was added to the A component to form a gel, and the C, D, and E components were further added and mixed while stirring. Then, it deaerated and obtained the uniform gel (translucent gel).

(Prescription Example 17)
"A component"
Carboxyvinyl polymer 0.5%
Purified water 40.0%
"B component"
Potassium hydroxide 0.1%
Purified water 10.0%
"C component"
Pantothenic acid derivative 0.5%
Dipropylene glycol 10.0%
Methylparaben 0.1%
Dipotassium glycyrrhizinate 0.05%
Hydrolyzed collagen 0.05%
Purified water residue

  A component, B component, and C component were mixed, A component and B component were dissolved at room temperature, and C component was dissolved by heating at 50 ° C. Next, while stirring the A component, the B component was added to the A component to form a gel, and the C component was further added and mixed while stirring. Then, it deaerated and obtained the uniform gel (translucent gel).

(Prescription Example 18)
"A component"
Glycerin 10.0%
1,3-butylene glycol 6.0%
Dimethicone 2.0%
PEG-60 hydrogenated castor oil 0.6%
Laureth-2 0.1%
Laureth-21 0.1%
Methylparaben 0.26%
Propylparaben 0.1%
Ethylparaben 0.1%
Phenoxyethanol 0.1%
Tocopherol acetate 0.1%
Chitosan Succinamide 0.01%
Yeast extract 0.1%
Ethanol 0.01%
Fragrance 0.01%
"B component"
Pantothenic acid derivative 0.5%
Carboxyvinyl polymer 0.5%
Urea 0.02%
Glucosamine hydrochloride 0.01%
Edetate disodium 0.01%
Purified water 50.0%
"C component"
Arginine 0.63%
Purified water residue

  A component, B component, and C component were mixed, A component was dissolved by heating at 60 ° C., and B component and C component were dissolved at room temperature. Next, while stirring the A component, the B component was added to the A component to form a gel, and the C component was further added and mixed while stirring. Then, it cooled to room temperature and obtained the uniform gel (translucent gel).

(Prescription Example 19)
"A component"
Pantothenic acid derivative 0.5%
Glycerin 50.0%
Tourmaline 5.0%
Olive oil 1.0%
PEG-12 28.0%
PEG-75 7.5%
Polyglyceryl laurate 1.0%
Ethanol 0.49%
Acrylic acid / alkyl acrylate (C10-30) copolymer 0.11%
Methylparaben 0.11%
Propylparaben 0.02%
Ginkgo biloba 0.02%
Cha extract 0.02%
Maronnier extract 0.02%
Brown algae extract 0.02%
"B component"
Carboxyvinyl polymer 0.07%
Purified water 3.0%
"C component"
Hydroxide Na 0.01%
Purified water residue

  A component, B component, and C component were mixed, A component was dissolved by heating at 60 ° C., and B component and C component were dissolved at room temperature. Next, while stirring the A component, the B component was added to the A component to form a gel, and the C component was further added and mixed while stirring. Then, it cooled to room temperature and obtained the uniform gel (translucent gel).

(Prescription Example 20)
"A component"
Pantothenic acid derivative 0.5%
Decamethylcyclopentasiloxane 20.0%
Potassium ascorbate 3.0%
"B component"
Squalane 50.0%
Light liquid isoparaffin Residue dextrin dextrin 8.0%
"C component"
Octyl paramethoxycinnamate 1.0%
Phenoxyethanol 0.5%
α-Tocopherol 0.1%

  The A component, B component, and C component were weighed, the A component was kneaded with a bead mill at room temperature, the B component was heated until it was uniformly dissolved, and the C component was dissolved at room temperature. Thereafter, while stirring the B component, the C component was added to the B component to make it uniform, and then cooled to room temperature while stirring. Next, component A was added thereto and stirred sufficiently to obtain a uniform gel (translucent gel).

[Example 7]
Preparation of cosmetic liquid A cosmetic liquid was prepared according to the following prescription examples 21-23. In the prescription example 21, the sum of the A to D components, in the prescription example 22, the sum of the A component and the B component, and in the prescription example 23, the sum of the A to C components is 100%, respectively. did.

(Prescription Example 21)
"A component"
Xanthan gum 0.4%
Hydroxyethyl cellulose 0.1%
Carboxyvinyl polymer 0.1%
1,3-butylene glycol 5.0%
Purified water 50.0%
"B component"
Potassium hydroxide (1% aqueous solution) 2.5%
Purified water 10.0%
"C component"
Pantothenic acid derivative 0.5%
Caffeine 1.0%
Purified water residue “D component”
Methylparaben 0.1%
Ethanol 3.0%

  A component, B component, C component, and D component were mixed, respectively, A component, B component, and D component were dissolved at room temperature, and C component was heated and dissolved at 50 ° C. Thereafter, while the A component was stirred, the B component was added to the A component to make a viscous liquid, and then the C component and D component were added and mixed with stirring to obtain a uniform liquid (beauty liquid).

(Prescription Example 22)
"A component"
Pantothenic acid derivative 0.5%
1,3-butylene glycol 10.0%
Glycerin 5.0%
Sodium hyaluronate 0.2%
Xanthan gum 0.2%
Dipotassium glycyrrhizinate 0.02%
Purified water residue “B component”
Ethanol 3.0%
Hydrogenated lecithin 0.5%
Trioctanoin 0.3%
Diphenyl dimethicone 0.2%
Methylparaben 0.22%
Phenoxyethanol 0.08%
PEG-50 hydrogenated castor oil 0.1%
PEG-60 hydrogenated castor oil 0.1%
α-Tocopherol 0.01%
Polyglyceryl myristate-10 0.05%

  The A component and the B component were mixed, and both the A component and the B component were heated and dissolved at 50 ° C. Next, while stirring the A component, the B component was added to the A component, mixed while stirring, and cooled with stirring to obtain a uniform liquid (beauty liquid).

(Prescription Example 23)
"A component"
Xanthan gum 0.4%
Hydroxyethyl cellulose 0.4%
1,3-butylene glycol 3.0%
Glycerin 3.0%
Methylparaben 0.1%
Purified water residue “B component”
Pantothenic acid derivative 0.5%
1,2-hexanediol 4.0%
Purified water 50.0%
"C component"
Ascorbic acid-2-magnesium phosphate 1.5%
Ascorbic acid-2-sodium phosphate 1.5%
Sodium citrate 0.5%
Edetate tetrasodium 0.1%
Purified water 9.4%

  A component, B component, and C component were mixed, A component and C component were dissolved at room temperature, and B component was dissolved by heating at 50 ° C. Thereafter, while the A component was stirred, the B component was added to the A component to make a viscous liquid, and then the C component was added and mixed with stirring to obtain a uniform liquid (beauty liquid).

[Example 8]
Preparation of cream A cream was prepared according to the following Formulation Example 24. In addition, in the formulation example 24, the sum total of A component and B component was 100%.

(Prescription Example 24)
"A component"
Hardened rape oil alcohol 4.2%
Isononyl isononanoate 6.0%
Squalane 9.6%
Octyldodecyl myristate 4.8%
Polyglyceryl monostearate 2.0%
Glyceryl stearate 1.0%
Propylparaben 0.05%
Xanthan gum 0.1%
α-Tocopherol 0.5%
"B component"
Pantothenic acid derivative 0.5%
1,3-butylene glycol 4.8%
Glycerin 4.8%
Sodium ascorbate-2-phosphate-6-palmitate 1.0%
Methylparaben 0.1%
Purified water residue

  The A component and the B component were mixed, and both the A component and the B component were heated and dissolved at 85 ° C. Next, while stirring the A component, the B component was added to the A component to emulsify, and the mixture was further cooled with stirring. Thereafter, stirring was stopped at around 40 ° C. and deaerated to obtain a cream.

[Example 9]
Manufacture of a sheet pack According to the following prescription examples 25 and 26, a sheet pack was manufactured. In the prescription examples 25 and 26, the total sum of the A component and the B component was 100%.

(Prescription Example 25)
"A component"
Glycerin 30.0%
Alumina magnesium hydroxide 1.0%
"B component"
Pantothenic acid derivative 0.5%
Diisopropanolamine 1.0%
Sodium polyacrylate 2.0%
Acrylic acid / sodium acrylate (50/50 (molar ratio)) copolymer 2.0%
Ascorbic acid-2-magnesium phosphate 3.0%
Purified water residue

(Prescription Example 26)
"A component"
1.3-Butylene glycol 30.0%
Aluminum hydroxide gel / sodium bicarbonate coprecipitate 0.05%
"B component"
Pantothenic acid derivative 0.5%
Sodium acrylate / acrylic acid (70/30 (molar ratio)) copolymer 1.0%
Polyacrylic acid 1.0%
N-vinylacetamide / sodium acrylate (9/1 (wt ratio)) copolymer 3.0%
Aluminum lactate 0.05%
Ammonia 10% aqueous solution 0.01%
Ascorbic acid-2-magnesium phosphate 0.01%
Purified water residue

  In any formulation example, the A component and the B component were mixed, the A component was dispersed at room temperature, and the B component was dissolved by heating at 50 ° C. Next, the B component was returned to room temperature while stirring, and kneaded while gradually adding the A component to the B component. The obtained sol was coated on a polypropylene liner with a knife coater with a clearance of 0.5 mm, then a non-woven fabric was stuck on the sol, put in an aluminum laminate bag, heat sealed, and aged for 3 days. A shaped pack was obtained.

[Example 10]
Preparation of Pack Agent A pack agent (peel off pack) was prepared according to the following Formulation Example 27. In addition, in the prescription example 27, the sum total of A component and B component was 100%.

(Prescription Example 27)
"A component"
Polyvinyl alcohol 13.0%
Carrageenan 0.5%
Purified water residue “B component”
Pantothenic acid derivative 0.5%
1,3-butylene glycol 3.0%
Methylparaben 0.1%
Ethanol 8.0%

  A component and B component were mixed, A component was heated and swollen at 50 ° C., and B component was dissolved at room temperature. Next, while stirring the A component, the B component was gradually added to the A component and mixed. Thereafter, the mixture was cooled while stirring, and the stirring was stopped at around 30 ° C. and left to obtain a peel-off pack.

[Example 11]
Preparation of bathing agent Bathing agents were prepared according to the following formulation examples 28 and 29. In the prescription examples 28 and 29, the total sum of the components was 100%.

(Prescription Example 28)
Pantothenic acid derivative 0.5%
Tetraoleic acid polyoxyethylene sorbitol 14.0%
Polyoxyethylene oleyl ether 3.0%
Sorbitan sesquioleate 3.0%
Squalane 10.0%
Jojoba oil 20.0%
Avocado oil 5.0%
Propylparaben 0.1%
Liquid paraffin residue

(Prescription Example 29)
Pantothenic acid derivative 0.5%
Sodium bicarbonate 35.5%
Citric acid 37.1%
Polyethylene glycol 2.1%
Magnesium oxide 1.1%
α-Tocopherol 1.2%
Ascorbic acid-2-sodium phosphate 1.5%
Ascorbic acid-2-glucoside 1.5%
In any formulation example, all the ingredients were stirred until uniform at room temperature to obtain a bath agent.

Claims (60)

A pantothenic acid derivative represented by the following general formula (1) and / or a salt thereof, and an effect promoter,
The effect promoter is an oily base, a moisturizer, a touch improver, a surfactant, a polymer, a thickening / gelling agent, a solvent, a propellant, an antioxidant, a reducing agent, an oxidizing agent, an antiseptic, an antibacterial agent Agent, chelating agent, pH adjuster, acid, alkali, powder, inorganic salt, UV absorber, whitening agent, vitamins and derivatives thereof, anti-inflammatory agent, anti-inflammatory agent, hair growth agent, blood circulation promoter, stimulant , Hormones, anti-wrinkle agents, anti-aging agents, anti-aging agents, cooling sensation agents, warming sensation agents, wound healing promoters, irritation mitigation agents, analgesics, cell activators, plant / animal / microbe extracts, antipruritic agents, keratin Stripping / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, pigment, water, metal-containing compound, unsaturated monomer, polyhydric alcohol, polymer additive Anti-inflammatory analgesic, antifungal, antihistamine, hypnotic sedative, tranquilizer, antihypertensive, antihypertensive Urine, antibiotics, anesthetics, antibacterial substances, antiepileptics, coronary vasodilators, herbal medicines, adjuvants, wetting agents, astringents, thickeners, tackifiers, antipruritics, keratin softening release agents, It is characterized by being one or more selected from oily raw materials, UV blockers, antiseptics, anti-oxidants, liquid matrices, fat-soluble substances, polymeric carboxylates, additives, metal soaps , Cosmetics or topical skin preparations.

(In General Formula (1), R ¹ and R ² are each independently a hydrogen atom or a linear or branched acyl group having 11 to 30 carbon atoms, and bonded to the carbonyl carbon of the acyl group. The hydrocarbon group is a saturated or unsaturated hydrocarbon group, and at least one of R ¹ and R ² is the acyl group.) The pantothenic acid derivative represented by the general formula (1) and / or a salt thereof is a pantothenic acid derivative represented by the following formula (1) -301 or (1) -302 and / or a salt thereof. The cosmetic or external preparation for skin according to 1.

  The salt of the pantothenic acid derivative is a salt formed with the inorganic anion or organic anion as the pantothenic acid derivative as a cation, or a salt formed with the inorganic or organic cation as the pantothenic acid derivative as an anion. The cosmetic or external preparation for skin according to claim 1 or 2.   The salt of the pantothenic acid derivative is converted into a cation, the nitrate ion, sulfate ion, carbonate ion, hydrogen carbonate ion, halogen ion, formate ion, acetate ion, citrate ion, tartrate ion, oxalate ion , Fumarate ion, anion of saturated or unsaturated chain fatty acid having 3 to 20 carbon atoms, anion of carnitine and its derivative, anion of hydroxycitrate and its derivative, anion of ascorbic acid, and ascorbyl phosphate and its derivative The cosmetic or external preparation for skin according to claim 1 or 2, which is a salt formed with one or more anions selected from the group consisting of anions.   The salt of the pantothenic acid derivative is selected from the group consisting of sodium ion, potassium ion, calcium ion, magnesium ion, zinc ion, ammonium ion, carnitine, and carnitine derivative cations, wherein the pantothenic acid derivative is an anion 1 The cosmetic or external preparation for skin according to claim 1 or 2, which is a salt formed with at least one kind of cation.   The cosmetic or skin external preparation according to any one of claims 1 to 5, wherein the pantothenic acid derivative and / or salt is contained in a total amount of 0.01 to 20% by mass.   Oily base is cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2 -Higher alcohols such as octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmi Tooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecane Higher fatty acids such as anteisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid and the like, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts and potassium salts, and amides, etc. Nitrogen-containing derivatives of: liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin, etc. Carbides: candelilla wax, carnauba wax, rice wax, wax wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, Waxes such as polyethylene wax and ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut Oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cacao Vegetable oils such as fat, shea fat, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil; Animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, reduced lanolin, adsorbed purified lanolin Lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin acetate alcohol, lanolins such as acetic acid (cetyl lanolyl) ester; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidyl Sphingophospholipids such as serine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phosphorus Phospholipid derivatives such as lipids; cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, cholic acid, etc. Terols; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl / octyldodecyl), N-lauroyl-L Acyl such as di-glutamate (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl), N-lauroyl sarcosine isopropyl Sarcosine alkyl ester, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid cholesteryl, macadamia nut oil fatty acid phytosteryl, isostear Sterol esters such as phytosteryl phosphate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; lipid complexes such as phospholipid / cholesterol complex, phospholipid / phytosterol complex Body: octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl pariminate, octyldodecyl palmitate, cetyl octanoate, hexyl decyl octanoate, isotridecyl isononanoate, isononyl isononanoate, isotridecyl isononanoate , Isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, olei Oleyl acid, octyldodecyl oleate, octyldodecyl ricinoleate, lanolin fatty acid octyldodecyl, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, ethyl avocado oil fatty acid, isopropyl myristate, palmitic acid Monoalcohols such as isopropyl, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, triethyl citrate Carboxylic acid esters; cetyl lactate, diisostearyl malate, monoisostearic acid hydrogenated castor oil, etc. Oxyacid esters; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, water Rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, neopentyl glycol dicaprate, dioctane 2-butyl-2-ethyl-1,3-propanediol acid, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenation logic Pentaerythrityl, triethylhexanoic acid ditrimethylolpropane, (isostearic acid / sebacic acid) ditrimethylolpropane, triethylhexanoic acid pentaerythrityl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diisostearate diglyceryl, tetraisostearic acid Polyglyceryl, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid / sebacic acid) diglyceryl oligoesters, polyvalent alcohols such as glycol distearate (ethylene glycol distearate) Fatty acid esters; diisopropyl dimerlinoleate diisopropyl, dimerdilinoleate diisostearyl, dimer dilinole Dimerisolinate (disteostearic acid / phytosteryl), dimerlinolinic acid (phytosteryl / behenyl), dimerlinoleic acid (phytosteryl / isostearyl / cetyl / stearyl / behenyl), dimerlinolinic acid dimerlinolinol Dimer acid or dimer diol derivatives such as dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, hydroxyalkyl dimer dilinoleyl ether; palm oil fatty acid monoethanolamide (cocamide MEA), palm oil Fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide ( Lauramide MIPA), fatty acid alkanolamides such as palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (Highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropyldimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol , Dimethiconol cross polymer, silicone resin, silicone rubber, aminopropyl dimethicone, amodimethicone, etc. Polyether-modified silicone such as amino-modified silicone, cation-modified silicone, dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphoric acid-modified silicone, sulfuric acid-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl Ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane / oxyalkylene copolymer, etc. Silicones; one or more selected from fluorine-based oils such as perfluorodecane, perfluorooctane and perfluoropolyether There, cosmetic or skin external preparation according to any one of claims 1-6.   Moisturizer / feel improver is a polyhydric alcohol such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, dipropylene glycol; NMF component such as sodium lactate, hyaluronic acid, collagen, Water-soluble polymers such as mucopolysaccharide and chondroitin sulfate; glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3 -Propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, ethylene glycol pro Polyols such as lenglycol copolymers and polymers thereof; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; sorbitol, xylitol, erythritol Sugar alcohols such as mannitol and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins ( α-, β-, γ-cyclodextrin, and modifications such as maltosylation and hydroxyalkylation Clodextrin), β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, glucosylethyl methacrylate polymer or copolymer, and derivatives thereof; hyaluron Acid, sodium hyaluronate; chondroitin sulfate sodium; mucoitin sulfate, caroline sulfate, kerato sulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharide; fucoidan; tuberose polysaccharide, naturally-occurring polysaccharide; organic such as citric acid, tartaric acid, lactic acid Urea; 2-pyrrolidone-5-carboxylic acid and its sodium salt; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, arani Amino acids such as phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and the like; collagen, fish-derived collagen , Atelocollagen, gelatin, elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzing keratin, conchiolin degrading peptide, hydrolyzing conchiolin, silk proteolytic peptide, hydrolyzing Silk, lauroyl hydrolyzed silk sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein Protein peptides such as degraded peptides and acylated peptides and derivatives thereof; acylated peptides such as palmitoyl oligopeptide, palmitoyl pentapeptide, palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, Bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerustin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, kon Animal and plant extract ingredients such as free extract, silk extract, Izayoi rose extract, yarrow extract, eucalyptus extract, and merryrot extract, natural ceramide (type 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudocerami , Glycosphingolipid is ceramides and sugar ceramides one containing selected from ceramides, such as extracts or two or more cosmetic or skin external preparation according to any one of claims 1-6. Surfactant is lauryl sulfate ester salt, polyoxyethylene alkyl ether sulfate, alkylbenzene sulfonate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkylphenyl ether phosphate, N-acyl amino acid salt, sodium stearate, Anionic surfactants such as potassium palmitate, sodium cetyl sulfate, sodium lauryl sulfate, triethanolamine palmitate, sodium polyoxyethylene lauryl phosphate, sodium acylglutamate, surfactin; benzalkonium chloride, benzethonium chloride, stearyltrimethyl chloride Cationic surfactants such as ammonium, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride; alkyldiamino hydrochloride Amphoteric surfactants such as tilglycine, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, lecithin; polyol fatty acid ester, glyceryl monostearate, glycerin monooleate , Ethylene glycol monostearate, propylene glycol monostearate, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkylphenol ether, polyoxyethylene sorbitol fatty acid ester, N -Acyl amino acid esters, sucrose fatty acid esters, fatty acid alkylol amides, polyoxyethylenated sterols, poly Nonionic surfactants such as xylethylenated lanolin and polyoxyethylene hydrogenated castor oil; fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate and ammonium lauryl sulfate; Polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine tri Acyl N-methylamino acid salts such as ethanolamine and sodium lauroylglutamate methylalanine; Acyl amino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; -Olefin sulfonates such as sodium olefin sulfonate; Alkyl sulfosuccinates such as disodium lauryl sulfosuccinate, dioctyl sodium sulfosuccinate; Disodium laureth sulfosuccinate, monolauroyl monoethanolamide sodium polyoxyethylene sulfosuccinate, lauryl polypropylene glycol Alkyl ether sulfosuccinates such as sodium sulfosuccinate; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and tetradecylbenzenesulfonate triethanolamine; alkylnaphthalenesulfonate; alkanesulfonate; α-sulfo fatty acid methyl ester Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; Alkyl ether phosphate salts such as sodium urethphosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide Ether phosphates; phospholipids such as phosphatidylglycerol, phosphatidylinositol, phosphatidic acid; anionic surfactants such as silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; Laureth (polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polio) Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers such as (ciethylene behenyl ether), isosteares (polyoxyethylene isostearyl ether), octyldecesses (polyoxyethylene octyldodecyl ether); Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester, Castor oil and hardened castor oil derivatives such as polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterol; polyoxyethylene cholesterol; Polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene / polyoxypropylene cetyl ether, polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene / polyoxypropylene monobutyl ether Polyoxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene glycerin ether and other polyoxyethylene / polyoxypropylene alkyl ethers; polyoxyethylene / polyoxypropylene glycol; PPG-9 diglyceryl and the like ( Poly) glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myris Glyceryl fatty acid partial esters such as glyceryl acid, glyceryl oleate, glyceryl coconut oil fatty acid glyceryl, mono-cotton oil fatty acid glycerin, mono-erucic acid glycerin, sesquioleic acid glycerin, α, α'-oleic acid pyroglutamic acid glycerin, monostearic acid glycerin malic acid Class: Polyglyceryl-2 stearate, 3, 4, 5, 6, 8, 10, 10 polyglyceryl distearate-6, 10 polyglyceryl tristearate, polyglyceryl decastearate-10, isostearic acid Acid polyglyceryl-2, 3, 4, 5, 6, 8, 10, diisostearate polyglyceryl-2 (diglyceryl diisostearate), 3, 10, diglyceryl triisostearate, tetraisostearate acid Polyglyceryl-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3, 4, 5, 6, 8, 10, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbita Sorbitan fatty acid esters such as monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, undecylenic acid Sugar derivative partial ester such as trehalose; alkyl glucoside such as caprylyl glucoside; alkyl polyglycoside; lanolin alcohol; reduced lanolin; polyoxyethylene distearate, polytylene glycol diisostearate, polyoxyethylene monooleate, polyoxy Polyoxyethylene fatty acid mono- and diesters such as ethylene dioleate; polyoxyethylene propylene glycol fatty acid ester; Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyethylene glycol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monooleate Polyoxyethylene sorbitan fatty acid esters such as oxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol Polyoxyethylene sorbitol fats such as pentaoleate and polyoxyethylene sorbitol monostearate Fatty acid ester; Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable fats and oils such as polyoxyethylene sorbitol beeswax; Isostearyl glyceryl ether, Kimyl alcohol, Serakyl alcohol, Batyl alcohol, etc. Polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; Coconut oil fatty acid monoethanolamide (cocamide MEA), Coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide Lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamid MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Ether-modified silicone, polysiloxane / oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone, etc. Nonionic surfactants such as silicone-based nonionic surfactants; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; stearyl Alkyltrimethylammonium bromides such as trimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines such as stearamidepropyldimethylamine and stearamideethyldiethylamine and salts thereof; stearoxypropyldimethylamine Alkyl ether amines and salts thereof or quaternary salts thereof; ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylan Fatty acid amide type quaternary ammonium salts such as ammonium, lanolin fatty acid aminopropylethyldimethylammonium sulfate; polyoxyethylene alkylamine and its salts or quaternary salts; alkylamine salts; fatty acid amidoguanidinium salts;

Alkyltrialkylene glycol ammonium salt; benzalkonium salt; benzethonium salt; pyridinium salt such as cetylpyridinium chloride; imidazolinium salt; alkylisoquinolinium salt; dialkyl morpholinium salt; polyamine fatty acid derivative; Amino-modified silicones such as dimethicone and amodimethicone, cation-modified silicones, cation- and polyether-modified silicones, silicone-based cationic surfactants such as amino- and polyether-modified silicones, etc .; lauryl betaine (lauryl dimethylamino acetate betaine) N-alkyl-N, N-dimethylamino acid betaines such as: fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine Imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; Sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, hydroxylated lecithin, etc. Phospholipids; amphoteric surfactants such as silicone-based amphoteric surfactants; polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / meta The cosmetic or skin external application according to any one of claims 1 to 6, wherein the alkyl acrylate copolymer is one or more selected from polymer surfactants such as various silicone surfactants. Agent.   High molecular weight, thickening and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, gum arabic, tara gum, tamarind, far celerin, karaya gum, troaroa, cara gum, tragacanth gum, pectin, pectic acid and sodium salt , Salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin, Chitosan, agar, gypsum extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypropyl cell Cellulose, carboxymethylcellulose and salts thereof such as sodium, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch , Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, corn starch succinate corn starch, and alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP) , Vinyl pyridone-vinyl alcohol copolymer, polyvinyl methyl ether; Lithium glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymer; (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, amphoteric methacrylate ester copolymer such as (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer Polymer: (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; polyvinyl acetate partial saponification product, maleic acid copolymer; vinyl pyrrolidone・ Dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; polyacrylic Amides; Polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, salts of polyacrylic acid and its sodium salts, acrylic acid / methacrylic acid ester copolymers; acrylic acid / methacrylic acid alkyl copolymers Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, and acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquaternium-47 Acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer, methacrylic acid choline ester polymer; cationized polysaccharide such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride; polyethyleneimine A cationic polymer; a polymer of 2-methacryloyloxyethyl phosphorylcholine such as polyquaternium-51 and a copolymer with a butyl methacrylate copolymer, etc .; acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion, polyacetic acid Polymer emulsions such as vinyl resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; Various silicone-based copolymers such as kryl-silicone graft copolymer; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoic acid palmitic acid Dextrin fatty acid ester such as ester; dextrin fatty acid ester such as myristic dextrin; silicic anhydride, fumed silica (ultrafine silicic anhydride), aluminum magnesium silicate, sodium magnesium silicate, metal soap, metal salt of dialkyl phosphate, Organic modified clay minerals such as bentonite, hectorite, dimethylbenzyl dodecyl ammonium montmorillonite clay, dimethyl dioctadecyl ammonium montmorillonite clay, sucrose palmitate Sucrose fatty acid esters such as tellurium and sucrose stearate, amino acid derivatives such as N-lauroyl-L-glutamic acid and α, γ-di-n-butylamine, benzylidene derivatives of sorbitol such as monobenzylidene sorbitol and dibenzylidene sorbitol The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is one or more selected from fructooligosaccharide fatty acid esters.   Solvent / propellant is monohydric alcohol such as methanol, ethanol, propanol, benzyl alcohol, phenethyl alcohol, isopropyl alcohol, isobutyl alcohol, hexyl alcohol, 2-ethylhexanol, cyclohexanol, octyl alcohol, butanol, pentanol, etc .; acetone, Ketones such as methyl ethyl ketone; lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol and isopentyl diol; Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethyl Glycol ethers such as glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether; ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, Glycol ether esters such as propylene glycol monoethyl ether acetate; Glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N- Methylpyrrolidone; toluene; fluorocarbon The makeup according to any one of claims 1 to 6, which is one or more selected from LPG, dimethyl ether, carbon dioxide, cellosolve, dioxane, dimethylformamide, dimethyl sulfoxide, and crotamiton. Or external preparation for skin.   Antioxidant / reducing agent / oxidant is a tocopherol derivative such as tocopherol (vitamin E) or tocopherol acetate; BHT, BHA; a gallic acid derivative such as propyl gallate; vitamin C (ascorbic acid) and / or a derivative thereof; Acids and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfites; thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine Hydrochloride, thioglycolic acid, cysteine, cysteamine; hydrogen peroxide, ammonium persulfate, sodium bromate, percarbonate, nordihydroguaiaretic acid, guaiac fat, butylhydroxyanisole, dibutylhydroxytoluene (BHT), 2, '- methylenebis (4-methyl -6-t-butyl) is one or more selected from phenol, cosmetic or skin external preparation according to any one of claims 1-6.   Preservatives, antibacterial agents and chelating agents are hydroxybenzoic acid such as methylparaben, ethylparaben, propylparaben and butylparaben and salts or esters thereof; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2 1,2-diols such as hexanediol; isothiazoline derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and salts thereof; phenols; halogenated bisphenols such as triclosan; acids Amides, quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene , Hinokitiol; other phenols such as phenol, isopropylphenol, cresol, thymol, parachlorophenol, phenylphenol, sodium phenylphenol; phenylethyl alcohol, photosensitizers, antibacterial zeolite, silver ion; EDTA, EDTA2Na, EDTA3Na, EDTA4Na Edetate (ethylenediaminetetraacetate) such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; phosphonic acid such as etidronate and its sodium salt; Sodium polyphosphate, polypolyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, It is 1 type, or 2 or more types chosen from acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid, pyrophosphate, hexametaphosphate, any one of Claims 1-6 Cosmetics or external preparations for skin described in 1.   pH adjusting agent / acid / alkali is sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1 , 3-propanediol, arginine, guanidine carbonate, ammonium carbonate, ammonia, aqueous ammonia, triethanolamine, dimethylamine, diethylamine, trimethylamine, triethylamine, triisopropanolamine, trisodium phosphate, disodium hydrogen phosphate, phosphoric acid Alkali metal hydroxides, alkaline earth metal hydroxides such as dipotassium hydrogen, monoethanolamine, diethanolamine, isopropanolamine, diisopropanolamine, polyethanolamine, primary, secondary or tertiary amines Killamine, or alkali such as primary, secondary or tertiary alkanolamine, citric acid, tartaric acid, lactic acid, glycolic acid, hydrochloric acid, nitric acid, citric acid, sodium citrate, sodium lactate, succinic acid, acetic acid Acid such as sodium acetate, fumaric acid, sulfuric acid, malic acid, phosphoric acid, alginic acid, polyglutamic acid, polyaspartic acid, starch-acrylic acid graft polymer, polyacrylic acid, polyvinyl acetate-crotonic acid copolymer, vinyl acetate -Shows acidity or alkalinity of (meth) acrylic acid copolymer, vinyl acetate-crotonic acid copolymer, polyvinyl sulfonic acid, polyitaconic acid, styrene-maleic anhydride copolymer, acrylamide-acrylic acid copolymer, etc. It is 1 type, or 2 or more types selected from polymer | macromolecule. Cosmetic or skin external preparation according to any one of 6.   Powders / inorganic salts are mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, phlogopite, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, Barium silicate, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud , Metal soaps (e.g., zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and ultrafine Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), titanium mica, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethyl Organic powders and surface-treated powders of various sizes and shapes, such as methacrylate powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder Sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum sulfate / potassium sulfate (Alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as phosphate 1Na, 2Na, 3Na, potassium phosphates, calcium phosphate , Magnesium phosphate , Magnesium oxide, lithium mica, silicic acid, magnesium magnesium silicate, vermiculite, hydrite, ceramic powder, dicalcium phosphate, aluminum hydroxide, boron nitride, etc .; organic powders include polyamide powder, polyester powder, polyethylene Powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, silk powder, nylon powder, 12 nylon, 6 nylon, styrene / acrylic acid copolymer, divinylbenzene・ Styrene copolymer, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, acrylic resin, melamine Resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder, lauroyl lysine, etc .; Colored pigments include inorganic red pigments such as iron oxide, iron hydroxide and iron titanate, inorganic brown pigments such as γ-iron oxide, yellow Inorganic yellow pigments such as iron oxide and ocher, inorganic black pigments such as black iron oxide and carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic such as chromium hydroxide, chromium oxide, cobalt oxide and cobalt titanate Green pigments, inorganic blue pigments such as bitumen and ultramarine blue, tar pigments raked, natural pigments raked, composite powders composed of these powders, etc .; titanium oxide coated mica, oxidation Titanium-coated mica, bismuth oxychloride, bismuth oxychloride, tantalum oxide-coated talc, fish scale foil, titanium oxide-coated colored mica, etc. Pigment: Metal powder pigment such as aluminum powder, copper powder, stainless steel powder; Red No. 3, Red No. 104, Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red 226, Red 227, Red 228, Red 230, Red 401, Red 505, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Yellow 204, Yellow 401, Blue 1 Blue 2, Blue 201, Blue 404, Green 3, Green 201, Green 204, Green 205, Orange 201, Orange 203, Orange 204, Orange 206, Orange 207, etc. Tar pigments; powders selected from natural pigments such as carminic acid, laccaic acid, calsamine, bradylin, crocin, etc., and these powders are combined or oiled, silico Or montmorillolite, anhydrous silicic acid, stone koji, diatomaceous earth, calcium carbonate, hydrotalcite, talc, glass, kaolin, metal soap, aerosil, bismuth oxychloride, fish scales The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is one or two or more selected from foil, zinc oxide, and titanium dioxide.   Ultraviolet absorbers are paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester Benzoic acid ultraviolet absorbers such as N, N-dimethylparaaminobenzoic acid butyl ester and N, N-dimethylparaaminobenzoic acid ethyl ester; anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid and Salicylic acid UV absorbers such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate Agents: Octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinna Mate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), cyclohexyl- p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxycinname Cinnamic acid-based ultraviolet absorbers such as phosphoric acid and its derivatives; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone UV absorption Agent; 3- (4'-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenyl 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3,3 -Dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- (3,4 -Dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, hydantoin derivatives such as dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, phenylbenzimidazolosulfonic acid, terephthalylidene dicanfursulfonic acid, Cosmetics or skin external preparation as described in any one of Claims 1-6 which is 1 type, or 2 or more types chosen from drometrizol trisiloxane, methyl anthranilate, rutin and its derivative (s), oryzanol and its derivative (s). .   Whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and esters thereof; ascorbic acid, ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt such as ascorbic acid phosphate magnesium, ascorbic acid tetra Ascorbic acid fatty acid ester such as isopalmitic acid ester, ascorbic acid alkyl ether such as ascorbic acid ethyl ether, ascorbic acid glucoside such as ascorbic acid-2-glucoside and its fatty acid ester, ascorbic acid sulfate ester, tocopheryl ascorbyl phosphate, etc. Ascorbic acid derivatives of kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcino , Oil-soluble chamomile extract, oil-soluble licorice extract, Nishikawayanagi extract, saxifrage extract, grabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, placenta extract, carotenoids and animal and plant extracts containing these, Neo agarobiose, agarose oligosaccharide, asparagus extract, ibukitorano extract, pea extract, age extract, ougon extract, onionis extract, seaweed extract, raspberry extract, cucumber extract, caquette extract , Scallop extract, plant oil containing linoleic acid, saicin extract, hawthorn extract, sampens extract, shirayuri extract, peonies extract, sempukuka extract, sohakuhi extract, soybean extract, tea extract, toki Extract, molasses extract, beech Cren extract, beech extract, grape seed extract, flow demanita extract, hop extract, mica squid extract, mokka extract, saxifrage extract, yokuinin extract and rahan extract, asparagus, akane, red grape, Akamegashiwa, akebi, asa, morning glory, azuki, asenyaku, achacha, achachaul, itadori, figs, ginkgo, ylang ylang, moray bolster, ume, walrus, wild boar, prairie cricket, shrimp, peas, pomegranate, blue whale Ominae, Dutch Strawberry, Oyster, Oyster, Catfish, Cashew, Valerian, Calla Lily, Karin, Guarana, Oyster, Chrysanthemum, Kisage, Gimishishi, Gymnema Silvesta, Kimihiki, Guava, Kuko, Kuzu, Kusuno , Chestnut, caquette, bay, keihi, gosho strawberry, pepper, coffee, licorice, colombo, sasanqua, salamander, saffron, cherry blossom, pomegranate, sandscon, sunpens, zion, shobu, watermelon, stevia, plum, quail, pear, Achillea millefolium, horsetail, horseradish, budgerigar, seri, senega, senna, daiou, daidai, tamarind, taran, dandelion, chicory, dung beetle, chosi, chorei, tsukimiso, tsubosa, tsuyuza, tsuruna, trogan , Nazuna, Natsumikan, Nanten, Nigaki, Yarrow, Pineapple, Hibiscus, Papaya, Basil, Lotus, Hadakamugi, Sagiri, Peanut, Hikioko , Hishi, Pistachio, Hiba, Himematsutake, Peacock, Biwa, Japanese dandelion, Fushinoki, Fujibakama, Blueberry, Bowfish, Japanese physalis, Honoki, Bokeh, Maikai, Maou, Mango, Mannentake, Mishimahae, Misohagi, Mitsuhami, Mitsuhama, Mitsuhama, Mitsuhama, Mitsuhama, Mitsumoe , Momordica grosbenoly, moroheiya, sprout, yakchi, yakso, cornflower, palm, yashajitsu, mistletoe, willow, pokeweed, bayberry, quail, wormwood, rye, orchid, orchid, apple, litchi, forsythia plant extract or forsythia plant extract The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is at least two kinds.   Vitamins and derivatives thereof are vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, riboflavin butyrate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine di Vitamin B group such as palmitic acid, flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, choline, etc .; vitamin C such as ascorbic acid and its sodium salt; vitamin D Vitamins such as α, β, γ, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid such as sodium ascorbate phosphate and magnesium ascorbate phosphate Acid ester salts, ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, ascorbyl dipalmitate, etc., ascorbic acid fatty acid esters such as ascorbic acid ethyl ether, ascorbic acid alkyl ethers such as ascorbic acid 2-glucoside, etc. Ascorbic acid glucoside and its fatty acid esters, ascorbic acid derivatives such as tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate tocopherol phosphate, and tocotrienols The cosmetic or external preparation for skin according to any one of Claims 1 to 6, which is one or more selected.   Anti-inflammatory agent, anti-inflammatory agent, hair growth agent, blood circulation promoter, stimulant, hormones, anti-wrinkle agent, anti-aging agent, squeeze agent, cooling sensation agent, warming sensation agent, wound healing promoter, stimulation relieving agent, analgesic Agents, cell activators include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; Plant extracts such as leaf extract; plant extracts and tinctures such as assembly extract, capsicum tincture, ginger tincture, ginger extract and cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid, borneol, cyclandrate Cinnarizine Trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and derivatives such as nicotinic acid tocopherol and acetic acid tocopherol, γ-oryzanol, nicotinic acid and nicotinic acid amide, nicotinic acid benzyl ester, inositol hexanicotinate, nicotine alcohol Derivatives, etc., allantoin, photosensitizer 301, photosensitizer 401, capronium chloride, pentadecanoic acid monoglyceride, flavonol derivative, stigmasterol or stigmasteranol and its glycoside, minoxidil; estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, Prednisone; retinols, retinoic acids, tocopheryl retinoic acid; lactic acid, glycolic acid, glucone , Derivatives of fruit acid, salicylic acid and glycosides / esterified products thereof, α- or β-hydroxy acids such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl and derivatives thereof; γ Carnitine; creatine; ceramides, sphingosines; caffeine, xanthine, and derivatives thereof; antioxidant / active oxygen scavengers such as coenzyme Q10, carotene, lycopene, astaxanthin; Catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol; derivatives such as rutin and glycosides; hesperidin and glycosides Derivatives such as Gnan glycosides; licorice extract-related substances such as grabrizine, glabrene, liquiritin, and isoliquiritin; lactoferrin; gingerol; fragrance substances such as menthol, camphor, and cedrol; and derivatives thereof; The cosmetic or skin external preparation according to any one of claims 1 to 6, which is one or more selected from a complex of a physiologically active substance and a cyclodextrin.   Plant / animal / microbe extract is iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, ginkgo biloba extract, inch Pepper extract, fennel extract, turmeric extract, oolong tea extract, walnut extract, ages extract, Echinacea leaf extract, enmeaux extract, peony extract, duckweed extract, laurel extract, barley extract, ginseng extract, hypericum extract, licorice extract, onionis extract, Netherlands Mustard extract, orange extract, dried seawater, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, Sea cucumber extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawarayomogi extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber extract, giraffe leaf extract, guanosine, guava Extract, Kujin Extract, Gardenia Extract, Kumazasa Extract, Clara Extract, Walnut Extract, Chestnut Extract, Grapefruit Extract, Clematis Extract, Black Rice Extract, Brown Sugar Extract, Black Vinegar, Chlorella Extract, Mulberry Extract, Gentianana Extract, Gennoshoco Extract, Black Tea Extract, Yeast Extract, kokuboku extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen Extract , Jatoba extract, peony extract, ginger cucumber extract, ginger root extract, white birch extract, white jellyfish extract, horsetail extract, stevia extract, stevia fermented product, Nishikawa willow extract, horseshoe extract, hawthorn extract, elderberry extract, yarrow extract, Mint extract, sage extract, mallow extract, nematode extract, assembly extract, Sakuhakuhi extract, Diou extract, soybean extract , Tiso extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, chimpi extract, tea tree oil, tea tea extract, red pepper extract, red pepper extract, red quince extract, red spruce extract, dodami extract, tomato extract , Natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, hamamelis extract, parietalia extract, hyacinth extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract , Dandelion extract, burdock extract, butterfly extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower Kiss, Peppermint extract, Bodaiju extract, Button extract, Hops extract, Maika extract, Pine extract, Maronnier extract, Citrus extract, Mukuroji extract, Melissa extract, Mozuku extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yuzu extract, Lily extract, Yokuinin extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is one or more selected from an extract and a bitumen extract.   Antipruritic agent, exfoliating / dissolving agent, antiperspirant, refreshing agent, astringent, enzyme, nucleic acid, diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor; salicylic acid, sulfur, resorcin, selenium sulfide, Pyridoxine; chlorohydroxyaluminum, aluminum chloride, zinc oxide, zinc paraphenolsulfonate; menthol, methyl salicylate, etc .; citric acid, tartaric acid, lactic acid, aluminum / potassium sulfate, tannic acid; superoxide dismutase, catalase, lysozyme chloride, lipase, It is 1 type (s) or 2 or more types chosen from papain, pancreatin, protease; ribonucleic acid and its salt, deoxyribonucleic acid and its salt, and adenosine triphosphate disodium, As described in any one of Claims 1-6. Cosmetics The external preparation for skin.   Perfumes such as coconut oil, orange oil, pepper oil, jasmine oil, cedar oil, ginger oil, terpin oil, orange flower oil, rose oil, eucalyptus oil, lime oil, lemon oil, Japanese mint oil, rosemary oil, etc. Vegetable fragrances; animal fragrances such as musk, reibiko, kairikou and rysenkou; hydrocarbon fragrances such as bromostyrol, pinene and limonene; alcohol fragrances such as benzyl alcohol and l-menthol; esters such as ethyl acetate and methyl salicylate Aldehydes such as benzaldehyde and salicylaldehyde; ketones such as camphor, muskone, musk ketone and l-menton; ethers such as safrole; phenols such as thymol; lactones Fragrance; Acid fragrance such as phenylacetic acid; Nitrogen compound fragrance such as indole Acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, ylang ylang oil, undecanal, undecenal, γ-undecalactone, estragole, oak moss, Opoponax resinoids, eugenol, auranthiol, galac solid, carvacrol, L-carvone, cannon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate , Styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sander Lewood oil, Santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole , Cinnamaldehyde, stylax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damasenone, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene, tripral, nerol, nonanal, 2,6-nonadienol , Nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone , Phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, methylnonyl Synthetic and natural flavors such as acetaldehyde, γ-methyl ionone, menthol, β-ionone, lavender oil, D-limonene, linalool, rillal, rigliall, rose absolute, rose oxide, rose oil, various essential oils, and various blended flavors. The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the cosmetic or external preparation is one or more.   Pigment / colorant / dye / pigment is brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204, Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1, Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213, Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 230-1 Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205, Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407 No., legal dyes such as Yellow 5; other acidic dyes such as Acid Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HCRed 3, 4-hydoxyprop Nitro dyes such as ylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2 and Basic Blue 26; disperse dyes; inorganic white such as titanium dioxide and zinc oxide Pigments: Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black iron oxide, low-order titanium oxide, etc. Inorganic pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen; titanium oxide coated mica; Titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, pearl pigments such as fish scale foil; metal powder such as aluminum powder, copper powder, gold Surface treatment inorganic and metal powder pigments: Red 201, Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5 No., Yellow 202, Yellow 203, Green No. 3, Blue No. 1, etc., organic pigments such as zirconium, barium or aluminum lake; surface treatment organic pigments; anthraquinones such as astaxanthin, alizarin, anthocyanidins, β-carotene, catenal , Capsanthin, Chalcone, Calsamine, Quercetin, Crocin, Chlorophyll, Curcumin, Cochineal, Chico Natural pigments / dyes such as naphthoquinones such as nin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, m-, or Oxidative dye intermediates and couplers such as p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; autooxidation type such as indoline The cosmetic or the external preparation for skin according to any one of claims 1 to 6, which is one or more selected from dyes; dihydroxyacetone.   The water is one or more selected from normal water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionic water, and cluster water. Item 7. The cosmetic or skin external preparation according to any one of Items 1 to 6. The metal-containing compound is lithium oxide, butyl lithium, ethyl lithium, lithium bromide, lithium carbide, lithium iodide, lithium nitrate, lithium nitride, lithium sulfide, methyl lithium, lithium sulfate, lithium chloride, lithium hydride, propyl lithium, Lithium carbonate, lithium fluoride, lithium niobate, lithium peroxide, lithium hydroxide, lithium molybdate, lithium perchlorate, lithium acetate, lithium formate, lithium tungstate, lithium hypochlorite, lithium acetate dihydrate , Lithium iodide dihydrate, lithium hydrogen sulfate, lithium acetate dihydrate, lithium bromide monohydrate, lithium sulfate monohydrate, dilithium carbonate, dilithium oxalate, dilithium sulfate, lithium chromate Dihydrate, Lithium hydroxide monohydrate, Lithium citrate Tetrahydrate, lithium perchlorate trihydrate, lithium compounds such as lithium hexafluorophosphate, sodium amide, sodium oxide, sodium azide, sodium acetate, sodium acetylide, sodium bromide, sodium formate, iodide Sodium, sodium lactate, sodium methoxide, sodium nitrate, sodium sulfate, sodium sulfide, sodium borate, metallic sodium, sodium bromate, sodium chloride, sodium hydride, sodium nitrite, sodium sulfite, sodium iodate, sodium phosphate , Ecabet sodium, sodium butyrate, heparin sodium, sodium chlorate, sodium citrate, sodium cyanate, sodium cyanide, sodium fluoride, sodium oleate, sodium oxalate, peracid Sodium, sodium silicate, sodium stannate, sodium-t-butoxide, sodium carbonate, suramin sodium, sodium benzoate, sodium chlorite, sodium chromate, sodium hydroxide, sodium selenate, sodium selenide, sodium laurate Inosinic acid (hereinafter abbreviated as IMP), disodium, sodium alginate, sodium perborate, sodium persulfate, sodium phosphite, sodium rhodanide, disodium arsenate, sodium selenite, sodium ampenac, tolme Chin sodium, sodium pyruvate, sodium saccharin, sodium aluminate, sodium gluconate, sodium polysulfide, sodium stearate, sodium valproate, sodium iopodate, heavy coal Sodium carbonate, disodium carbonate, sodium periodate, sodium leviparin, porfimer sodium, carmonam sodium, cefminox sodium, flomoxef sodium, cephalotin sodium, cefazolin sodium, latamoxef sodium, sodium glutamate, molybdenum Sodium phosphate, sodium percarbonate, sodium perchlorate, sodium salicylate, sodium thiosulfate, thiamylal sodium, triclofos sodium, sodium bicarbonate, sodium dichromate, sodium dichromate, sodium borofluoride, sodium acid sulfide phosphate Disodium, beraprost sodium, cefotetan sodium, ceftezol sodium, faropenem sodium, trisodium citrate, cefa Phosphorus sodium, ampicillin sodium, cefoxitin sodium, cefsulodin sodium, cefuroxime sodium, dantrolene sodium, sodium antimonate, sodium dithionite, sodium propionate, sodium tungstate, sodium pyrosulfite, trisodium phosphate , Sodium triphosphate, dalteparin sodium, parnaparin sodium, danaparoid sodium, cefodizime sodium, carmellose sodium, iotalamate sodium, foscarnet sodium, sodium metasulfite, cefotaxime sodium, cefpiramide sodium, cyclamic acid Sodium, diclofenac sodium, sodium borohydride, sodium hypochlorite, sodium thiocyanate, thiope Tar sodium, ticarcillin sodium, fosfomycin sodium, sodium arsenate, dibasic sodium phosphinate, sodium hyaluronate, imitrodast sodium, bucladecin sodium, sodium borohydride, sodium glucuronate, sodium aluminum sulfate, cefmeta Zole sodium, ceftizoxime sodium, cloxacillin sodium, sodium cyclamate, fluorescein sodium, liothyronine sodium, loxoprofen sodium, piperacillin sodium, sodium hydrosulfite, sodium hypophosphite, sodium naphthionate, sodium permanganate Sodium pyrophosphate, fluvastatin sodium, pravastatin sodium, rabeprazole sodium, Sodium tacrylate, 5'-IMP disodium, amobarbital sodium, cefamandole sodium, cefoperazone sodium, sodium ferrocyanide, sodium hydrogen sulfide, sodium metavanadate, sodium silicofluoride, sodium xanthate, sodium fluoroacetate, lauryl Sodium sulfate, sodium cromoglycate, sodium picosulfate, sodium fluoroacetate, sodium metabisulfite, sodium taurocholate, cerivastatin sodium, sodium acetate trihydrate, ceftriaxone sodium, carbenicillin sodium, cefbuperazone sodium, fumarate Monosodium acid, sodium levothyroxine, sodium dehydroacetate, sodium bisulfite, sulbenicillin na Thorium, sodium borate decahydrate, sodium metavanadate, sodium metaperiodate, sodium cholate hydrate, sodium sulfate decahydrate, sodium dodecyl sulfate, sodium secobarbital, lobenzalite disodium, deoxycholic acid Sodium, sodium nitroprusside, dicloxacillin sodium, sodium phthalocyanine, sodium thioglycolate, disodium sulfate, sodium dihydronaphthalenidyl, sodium gold thiomalate, 2-biphenylol sodium, sodium cholate n hydrate, sodium stannate Trihydrate, sodium sulfide nonahydrate, disodium calcium edetate, sodium epoprostenol, sodium ferrous citrate, anhydrous sodium carbonate, sodium sulfite Hydrate, sodium silicate aluminate, sodium benzoate caffeine, disodium hydrogen arsenate, sodium saccharin dihydrate, dibasic sodium phosphate, sodium trichloroacetate, sodium tripolyphosphate, sodium peroxodisulfate, sodium bromfenac Hydrate, sodium molybdate dihydrate, basic sodium phosphate, tribasic sodium phosphate, sodium trifluoroacetate, tetrasodium pyrophosphate, sodium chromate tetrahydrate, sodium succinate hexahydrate , Sodium dihydrogen citrate, sodium stearyl fumarate, sodium antimony tartrate, sodium cyanoborohydride, sodium dihydrogen phosphate, sodium plasterone sulfate, sodium selenite pentahydrate, dipicrylamine sodium, Sodium xametaphosphate, sodium perborate tetrahydrate, sodium tetrahydroborate, sodium acyl β-alanine, disodium hydrogen phosphate, sodium perchlorate monohydrate, (+)-sodium pantothenate, sodium metasilicate (Anhydrous), sodium tetrafluoroborate, sodium sulfanilate dihydrate, sodium cellulose sulfate, pantoprazole sodium hydrate, sodium chondroitin sulfate, disodium methylarsonate, sodium hexafluorosilicate, sodium riboflavin phosphate, Sodium dextran sulfate sulfur, trisodium phosphate dodecahydrate, disodium 5'-guanylate, disodium 5'-inosinate, sodium dextran sulfate sulfur 18, sulfobromophthalein sodium 5'-cytidylic acid disodium, lauryl sulfonic acid sodium salt, betamethasone sodium phosphate, polystyrene sulfonate sodium, prednisolone sodium phosphate, pentachlorophenol sodium salt, dichloroisocyanuric acid sodium salt, dexamethasone sodium phosphate, est phosphate Ramustine sodium, sodium prednisolone succinate, sodium hydrogen fumarate, sodium hexacyanoferrate (II), sodium 1-dodecanesulfonate, sodium dihydrogen phosphate dihydrate, sodium carbazochrome sulfonate, sodium hydrocortisone phosphate, 2 -Sodium hydroxypropanoate, sodium pyrophosphate decahydrate, disodium dihydrogen pyrophosphate, sodium triacetoxyborohydride, koha Acid hydrocortisone sodium, dibasic sodium phosphate dodecahydrate, colistin sodium methanesulfonate, sodium dodecylbenzenesulfonate, chloramphenicol sodium succinate, sodium 2-hydroxypropionate, (Z) -9-octadecene Acid sodium, disodium 2-hydroxysuccinate, sodium cyclohexylsulfamate, sodium flavin adenine dinucleotide, disodium uridine-5'-diphosphate, sodium diphenylamine-4-sulfonate, methylprednisolone sodium succinate, inosine 5 ' -Monophosphate sodium salt, inosine-5'-disodium phosphate, sodium N-cyclohexylsulfamate, cytidine 5'-disodium phosphate, guanosine-5 ' Disodium phosphate, 1-sodium (E) -2-butenedioate, sodium dexamethasone metasulfobenzoate, sodium 2,4-dichlorophenoxyacetate, sodium (2,4-dichlorophenoxy) acetate, 1,5- Naphthalenedisulfonic acid disodium, pentachlorophenol, sodium salt (industrial), sodium 4- (2,4-dichloro-m-toluoyl) -1,3-dimethylpyrazole-5-olate, 2-methyl-4-chloro Sodium phenoxyacetate, sodium (4-chloro-2-methylphenoxy) acetate, sodium [(4-chloro-2-methylphenyl) oxy] acetate, hydrogenated coconut oil fatty acid sodium glycerol sulfate, sodium 5-ethyl-5,8- Dihydro-8-oxofuro [3,2-b] [1,8] na Tyridine-7-carboxylate, trisodium 2-hydroxy-1,2,3-propanetricarboxylate, disodium 1-phenylazo-2-naphthol-4 ′, 6-disulfonate, 1- (p-sodiosulfophenyl) Azo) -2-hydroxynaphthalene-6-sulfonic acid sodium salt, 6-hydroxy-5-[(4-sulfophenyl) azo] -2-naphthalenesulfonic acid disodium salt, 2-hydroxy (1,1′-azobisnaphthalene) ) -3,4 ', 6-trisulfonic acid trisodium, (+)-N-[(R) -2,4-dihydroxy-3,3-dimethylbutyryl] -β-alanine sodium, 4-[( 2,4-Dimethylphenyl) azo] -3-hydroxy-2,7-naphthalenedisulfonate, (+)-3-[[(R) -2,4-di Droxy-3,3-dimethylbutyryl] amino] sodium propionate, [methyl (2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl) amino] methane Sodium compounds such as sodium sulfonate, potassium alum, potassium oxide, potassium bromide, potassium iodide, potassium nitrate, potassium sulfate, potassium sulfide, potassium acetate, potassium bromate, potassium chloride, potassium nitrite, potassium sulfite, potassium arsenate, Potassium iodate, potassium hydride, potassium t-butoxide, potassium carbonate, potassium chlorate, potassium cyanate, potassium cyanide, potassium fluoride, potassium oxalate, potassium silicate, potassium arsenite, potassium stannate, potassium chromate , Potassium hydroxide, lithium Potassium acid, potassium sorbate, potassium bisulfate, potassium selenate, potassium persulfate, potassium rhodanide, losartan potassium, potassium selenite, potassium tellurite, warfarin potassium, potassium periodate, potassium gluconate,

Potassium canrenoate, potassium perchlorate, potassium thiosulfate, potassium dichromate, potassium borofluoride, potassium dichromate, potassium molybdate, potassium pyrosulfite, potassium aspartate, potassium pemirolast, potassium hypochlorite, Potassium thiocyanate, potassium clavulanate, potassium aluminum sulfate, potassium cyanide sulfate, potassium boron hydroxide, potassium hypophosphite, potassium metaphosphate, potassium permanganate, potassium pyrophosphate, potassium ferricyanide, potassium ferrocyanide, potassium silicofluoride, Potassium hydrogen sulfate, potassium metavanadate, potassium xanthate, potassium hydrogen oxalate, dipotassium chlorazepate, potassium selenocyanate, dipotassium oxalate, potassium fluorosilicate, Potassium dihydrate trihydrate, potassium hydrogen carbonate, potassium peroxodisulfate, potassium aluminum sulfate, tetrapotassium pyrophosphate, benzylpenicillin potassium, potassium (methylsulfinyl) methanide, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, glycyrrhizin Dipotassium acid, potassium tetrafluoroborate, potassium guaiacol sulfonate, potassium hexafluorosilicate, potassium aluminum sulfate dodecahydrate, o-ethyl potassium dithiocarbonate, potassium hexacyanoiron (III), phenoxymethylpenicillin potassium, ( 2E, 4E) potassium compounds such as potassium 2,4-hexadienoate, rubidium oxide, rubidium bromide, rubidium iodide, rubidium sulfate, rubidium chloride, rubidium fluoride, rubidium acetate Rubidium compounds such as rubidium hydrogen sulfate and dibidium carbonate, cesium cyanide, cesium oxide, cesium bromide, cesium iodide, cesium nitrate, cesium sulfate, cesium chloride, cesium carbonate, cesium fluoride, dicesium carbonate, dicesium oxalate, sulfuric acid Cesium compounds such as dicesium, cesium L-tartrate, cesium hydroxide monohydrate, cesium trifluoroacetate, 1-cesium 2,3-dihydroxybutanedioate, 1-cesium hydrogen 2,3-dihydroxybutanedioate , Beryllium oxide, beryllium bromide, beryllium carbide, beryllium iodide, beryllium nitride, beryllium sulfide, beryllium chloride, beryllium fluoride, beryllium silicate, beryllium distearate, beryllium sulfate tetrahydrate, acetylacetone beryl Beryllium compounds such as lithium salts, magnesium oxide, magnesium orotate, arylmagnesium, magnesium acetate, magnesium boride, magnesium bromide, magnesium carbide, magnesium iodide, magnesium nitrate, magnesium nitride, magnesium sulfate, magnesium sulfide, magnesium (powder) ), Magnesium chloride, magnesium carbonate, magnesium chlorate, magnesium citrate, magnesium fluoride, magnesium silicate, magnesium silicide, magnesium hydroxide, magnesium phosphide, magnesium orotate, magnesium nitrate (II), magnesium stearate, Magnesium perchlorate, magnesium myristate, magnesium oxalate, magnesium bicarbonate, magnesium silicofluoride, fluorosilica Magnesium, phenyl magnesium bromide, magnesium nitrate hexahydrate, phthalocyanine magnesium, magnesium acetate tetrahydrate, magnesium benzoate trihydrate, calcium carbonate magnesium, magnesium chromate pentahydrate, magnesium hexafluorosilicate, Magnesium compounds such as magnesium aluminate metasilicate, bismuth magnesium aluminate silicate, magnesium magnesium carbonate carbonate hydrate, calcium carbide, calcium oxide, calcium bromide, calcium carbide, calcium cyanamide, calcium iodide, calcium lactate, nitric acid Calcium, calcium nitride, calcium sulfate, calcium sulfide, calcium acetate, calcium chloride, calcium nitrite, calcium sulfite, calcium arsenate, hydrogenated potassium Calcium arsenate, calcium iodate, calcium carbonate, calcium chlorate, calcium fluoride, calcium oxalate, calcium peroxide, calcium silicate, calcium silicide, calcium cyanide, calcium arsenite, heparin calcium, chlorite Calcium oxide, calcium chromate, calcium hydroxide, calcium phosphate, calcium phosphide, folinate calcium, calcium gluconate, calcium stearate, calcium aspartate, calcium hypochlorite, fosfomycin calcium, calcium metasilicate, calcium thiocyanate, hypoxia Calcium phosphate, calcium pantothenate, calcium permanganate, calcium fenoprofen, calcium chloride dihydrate, calcium carbonate, polycarbonate Lubefil calcium, mupirocin calcium hydrate, calcium hydrogen phosphate, calcium glycerophosphate, calcium diiodostearate, precipitated calcium carbonate, disodium calcium edetate, atorvastatin calcium hydrate, (+)-calcium pantothenate, calcium paraaminosalicylate , Calcium tocopherol succinate, calcium polystyrene sulfonate, (+)-calcium pantothenate (2: 1), calcium aluminoparaaminosalicylate, 3-hydroxy-4-[(4-methyl-2-sulfophenyl) azo]- Calcium compounds such as 2-naphthalenecarboxylic acid calcium salt, barium oxide, barium azide, barium acetate, barium bromide, barium iodide, barium nitrate, barium nitride, barium sulfate Barium sulfide, barium formate, barium lactate, barium chloride, barium sulfite, barium carbonate, barium chlorate, barium fluoride, barium peroxide, barium cyanide, barium chromate, barium hydroxide, barium titanate, selenate Barium, barium phosphate, barium nitrate (II), barium selenite, barium manganate, barium oxalate, barium stearate, barium perchlorate, barium thiosulfate, barium hypochlorite, barium permanganate, chloranil Barium acid, Barium chloride dihydrate, Barium diacetate, Barium bromide dihydrate, Barium dipropionate, Barium chlorate monohydrate, Barium hydroxide octahydrate, Barium thiocyanate dihydrate , Barium thiosulfate monohydrate, barium acetylacetone dihydrate What barium compound, it is one or more selected from, cosmetic or skin external preparation according to any one of claims 1-6.   As unsaturated monomers, acrylic acid polymers, maleic acid, maleic anhydride, fumaric acid, crotonic acid, itaconic acid, vinyl sulfonic acid, styrene sulfonic acid, 2- (meth) acrylamide-2-methylpropane sulfonic acid , 2- (meth) acryloylethanesulfonic acid, 2- (meth) acryloylpropanesulfonic acid-containing hydrophilic unsaturated monomers and salts thereof; N-vinylacetamide, N-methyl-N-vinylacetamide , Acrylamide, methacrylamide, N-ethyl (meth) acrylamide, Nn-propyl (meth) acrylamide, N-isopropyl (meth) acrylamide, N, N-dimethyl (meth) acrylamide, 2-hydroxyethyl (meth) acrylate , 2-hydroxypropyl (meth) acrylate, Nonionic hydrophilic unsaturated monomers such as xylethylene glycol (meth) acrylate, polyethylene glycol mono (meth) acrylate, vinylpyridine, N-vinylpyrrolidone, N-acryloylpiperidine, N-acryloylpyrrolidine; N, N- Cations such as dimethylaminoethyl (meth) acrylate, N, N-diethylaminoethyl (meth) acrylate, N, N-dimethylaminopropyl (meth) acrylate, N, N-dimethylaminopropyl (meth) acrylamide and quaternary salts thereof 2 or more selected from the group consisting of hydrophilic hydrophilic unsaturated monomers, styrene, vinyl chloride, butadiene, isobutene, ethylene, propylene, stearyl (meth) acrylate, and lauryl (meth) acrylate. ~ 6 Cosmetic or skin external preparation according to the deviation or claim.   Polyhydric alcohol is ethylene glycol, propylene glycol, 1,3-butylene glycol, ethylene glycol monobutyl ether, diethylene glycol, triethylene glycol, 1,4-butylene glycol (dihydric alcohol), glycerin, trioxyisobutane (trihydric alcohol) ), Erythritol, pentaerythritol (tetrahydric alcohol), xylite, adnit (pentahydric alcohol), allosulfite, sorbitol, sorbitol, mannitol (hexahydric alcohol), polyglycerin, dipropylene glycol The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the cosmetic or external preparation is a seed or more.   N-vinylacetamide-based copolymer such as polyvinylpyrrolidone, carboxyvinyl polymer that is cross-linked polyacrylic acid, vinylpyrrolidone-ethyl acrylate copolymer, N-vinylacetamide-sodium acrylate copolymer The compound, N-vinylacetamide homopolymer, polyvinyl sulfonic acid, N-vinylacetamide cross-linked product, polyitaconic acid, hydroxypropylcellulose, hydroxypropylmethylcellulose, or one or more kinds thereof, Cosmetics or a skin external preparation as described in any one of Claims.   Anti-inflammatory analgesics are salicylic acid, glycol salicylate, methyl salicylate, 1-menthol, camphor, sulindac, trimethine sodium, naproxen, fenbufen, piroxicam, triamcinolone, hydrocortisone acetate, indomethacin, ketoprofen, acetaminophen, mefenamic acid, flufenamic acid, Ibufenac, loxoprofen, thiaprofen, pranoprofen, fenbufen, diclofenac, diclofenac sodium, alclofenac, lornoxicam, mepranoprofen, oxyphenbutazone, ibuprofen, felbinac, ketorolac, vermoprofen, nabumetone, naproxen, flurbipro Fen, fluocinonide, clobetasol propionate, COX-2 inhibitor A cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the preparation is one or more selected from celecoxib, rofecoxib, valecoxib, parecoxib, valdecoxib, etodol, nyslide, meloxicam .   Antifungal agents include clotrimazole, econazole nitrate, omoconazole nitrate, thioconazole nitrate, ketoconazole nitrate, miconazole nitrate, isoconazole nitrate, tolnaftate, sulconazole nitrate, pyrrolnitrin, pimafucin, undecylenic acid, salicylic acid, cyctanine, nystatin, nornaphthamide, exolamide Or at least one selected from phenyliodoundecinoate, thianthol, ciclopirox olamine, haloprozin, tricomycin, variotin, pentamycin, and amphotericin B. The cosmetic or external skin preparation described.   One or two antihistamines selected from tetracycline hydrochloride, diphenhydramine hydrochloride, chlorpheniramine, diphenylimidazole, chloramphenicol and the like, diphenhydramine, chlorpheniramine maleate, diphenhydramine hydrochloride, chlorpheniramine, diphenylimidazole The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the cosmetic or external preparation is a seed or more.   The cosmetic or skin external preparation according to any one of claims 1 to 6, wherein the hypnotic sedative is one or more selected from phenobarbital, amobarbital, cyclobarbital, lorazepam, and haloperidol.   The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the tranquilizer is one or more selected from fluphenazine, theoridazine, diazepam, flunitrazepam, and chlorpromazine.   The antihypertensive agent is one or more selected from clonidine, clinidine hydrochloride, pindolol, propranolol, propranolol hydrochloride, bufuranol, indenolol, bucmolol, nifedipine, according to any one of claims 1 to 6. The cosmetic or external skin preparation described.   The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the antihypertensive diuretic is one or more selected from hydrothiazide and cyclopenthiazide.   The cosmetic according to any one of claims 1 to 6, wherein the antibiotic is one or more selected from penicillin, tetracycline, oxytetracycline, fradiomycin sulfate, erythromycin, and chloramphenicol. Skin external preparation.   The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the anesthetic is one or more selected from lidocaine, benzocaine, ethyl aminobenzoate, and dibucaine.   The cosmetic according to any one of claims 1 to 6, wherein the antibacterial substance is one or more selected from benzalkonium chloride, nitrofurazone, nystatin, acetosulfamine, and clotrimazole. Or skin external preparation.   The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the antiepileptic agent is one or more selected from nitrazepam, meprobamate, and clonazepam.   The coronary vasodilator is one or more selected from nitroglycerin, nitroglycol, isosorbidinitrate, erythritol tetranitrate, pentaerythritol tetranitrate, and propatyl nitrate. Cosmetics or skin external preparation as described in any one of 1-6.   Herbal medicines are: buckwheat, euhi, onji, gadgets, chamomile, caroten, licorice, koki, kyounin, gou, trash, cycachi, psycho, saishin, sardine, shoma, senega, sojutsu, sakuhaku, choji, chimney, tokon, mint The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is one or more selected from Bacmondou, Hange, Beaked Jutsu, Hiyos, Bow, and Maou.   Adjuvant is ethyl alcohol, isopropyl alcohol, butanol, 1,3 butanediol, propylene glycol, polyethylene glycol # 400, glycerin, crotamiton, benzyl alcohol, phenylethyl alcohol, propylene carbonate, hexyldodecanol, propanol, salicylic acid, allantoin, Dimethyl sulfoxide, dimethylacetamide, dimethylformamide, diisopropyl adipate, diethyl sebacate, ethyl laurate, lanolin, azone, 1-geranylazasilroheptan-2-one (GACH), fatty acid dialkyrolamide, salicylic acid, salicylic acid derivative, urea , Keratin softeners such as sulfur, humectants such as pyrrolidone carboxylic acid, propylene glycol monooleate, polyoxyethylene Surfactants such as rubitan monostearate, sorbitan monostearate, glycerin monostearate, esters such as isopropyl myristate and diethyl sebacate, higher alcohols such as oleyl alcohol, stearyl alcohol and lauryl alcohol, stearic acid, Terpenes such as hexanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, octadecanoic acid, oleic acid, linoleic acid, menthol, menthone, limonene, pinene, piperiton, terpinene, terpinolene, terpinolol, carbeol Compounds and surfactants, allantoin, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, diisopropyl adipate, diethyl sebacate, ethyl laurate Auxiliary agents such as lanolin and aison, and other refreshing agents such as menthol and camphor, almond oil, olive oil, camellia oil, persic oil, mint oil, sesame oil, soybean oil, mink oil, cottonseed oil, corn oil, 1 selected from oil components such as safflower oil, palm oil, eucalyptus oil, castor oil, liquid paraffin, petrolatum, squalene, squalane, lanolin, gelling agent such as carboxyvinyl polymer, and neutralizing agent such as diisopropanolamine The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is a seed or two or more kinds.   The wetting agent is one or more selected from glycerin, propylene glycol, sorbit, 1,3-butylene glycol, dl-pyrrolidone carboxylic acid and sodium lactate, according to any one of claims 1 to 6. The cosmetic or external skin preparation described.   The astringent is selected from citric acid, tartaric acid, lactic acid, aluminum chloride, aluminum sulfate, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum phenolsulfonic acid, zinc paraphenolsulfonic acid, zinc sulfate, aluminum chlorohydroxide Or the cosmetics or skin external preparation as described in any one of Claims 1-6 which is 2 or more types.   Thickeners include gum arabic, tragacanth gum, locust bean gum, guar gum, echo gum, karaya gum, agar, starch, carrageenan, alginic acid, alginates (e.g. sodium alginate), propylene glycol alginate, dextran, dextrin, amylose, gelatin, collagen, Natural polymers such as pullulan, pectin, amylopectin, starch, amylopectin sodium semiglycolate, chitin, albumin, casein, polyglutamic acid, polyaspartic acid, methylcellulose, ethylcellulose, propylcellulose, ethylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, Hydroxypropyl methylcellulose, carboxymethyl starch, alkali metal cal Semi-synthetic polymers such as xymethyl cellulose, alkali metal cellulose sulfate, cellulose graft polymer, crosslinked gelatin, cellulose acetate phthalate, starch-acrylic acid graft polymerization, phthalic anhydride modified gelatin, succinic acid modified gelatin, polyvinyl alcohol, polyvinyl Pyrrolidone, polyvinyl methyl ether, carboxyvinyl polymer, vinyl pyrrolidone-ethyl acrylate copolymer, vinyl pyrrolidone-styrene copolymer, vinyl pyrrolidone-vinyl acetate copolymer, vinyl acetate- (meth) acrylic acid copolymer, polyvinyl N-vinylacetamide copolymers such as acetate-crotonic acid copolymer, N-vinylacetamide-sodium acrylate copolymer, polyvinylsulfonic acid, N-vinylacetamide It is 1 type (s) or 2 or more types selected from a bridge | crosslinking body, poly itaconic acid, polyhydroxyethyl acrylate, polyacrylamide, a styrene-maleic anhydride copolymer, an acrylamide-acrylic acid copolymer of Claims 1-6. Cosmetics or a skin external preparation as described in any one of Claims.   The tackifier is one or more selected from silicone rubber, polyisoprene rubber, styrene-block copolymer rubber, acrylic rubber, and natural rubber, according to any one of claims 1 to 6. Cosmetics or topical skin preparations.   Cosmetic agent according to any one of claims 1 to 6, wherein the antidiarrheal agent is one or more selected from camphor, thymol, menthol, polyoxyethylene lauryl ether, antihistamine, and ethyl aminobenzoate. Or external preparation for skin.   The cosmetic or skin external preparation according to any one of claims 1 to 6, wherein the keratin softening release agent is one or more selected from sulfur, thioxolone, selenium sulfide, salicylic acid, and resorcin.   Oily ingredients are almond oil, olive oil, hydrogenated oil, camellia oil, castor oil, mole oil, coconut oil, beeswax, whale wax, lanolin, carnauba wax, candelilla wax, liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, Lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, octyldodecanol, cholesterol, hexyl decanol, white sterol, cetyl lactate, isopropyl myristate, hexyl laurate , Myristyl myristate, isopropyl palmitate, octyldodecanol myristate, butyl stearate, cacao oil, tree wax, jojoba oil, grape seed oil Avocado oil, mink oil, egg yolk oil, beeswax, whale wax, lanolin, carnauba wax, candelilla wax, liquid paraffin, ceresin wax, paraffin wax, behenic acid, isopropyl adipate, octyldodecyl oleate, octyldodecyl oleate, cholesterol The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is one or more selected from oleate.   UV blockers include ASL-24, Cyasorb UV-9, benzophenone series such as Uvinul M-40, benzoic acid series such as Salol, azole series such as Tinuvin P, nitrile series such as Uvinul N-35, Ancour UA, etc. 1 selected from para amino acids such as urea, Neo Heliopan Give tan F, 2-hydroxy-4-methoxybenzophenone, octyldimethylparaaminobenzoate, ethylhexylparamethoxycynamate, salicylic acid, benzofuran, coumarin, and azole The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is a seed or two or more kinds.   Antiseptic disinfectants are acids such as benzoic acid, salicylic acid, dehydroacetic acid, sorbic acid, boric acid and their salts, phenol, chlorocresol, chlorxylenol, isopropylmethylphenol, resorcin, orthophenylphenol, paraoxybenzoic acid ester, phenoxyethanol, Phenolic compounds such as thymol, hinokitiol, thioxolone, halogenated bisphenols such as hexachlorophene, 2,4,4'-trichloro-2'-hydroxydiphenyl ether, amides such as trichlorocarbanilide, halocarban, udecylenic acid monoethanolamide Compounds, quaternary ammonium compounds such as benzalkonium chloride, alkylisoquinolinium bromide, benzethonium chloride, cetylpyridinium chloride, lauryldi (aminoethyl) 1 selected from amphoteric surfactants such as lysine, 2-pyridinethiol-1-oxide zinc salt, gluconic acid, chlorhexidine, thyram, N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide, chlorobutanol The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is a seed or two or more kinds.   Antioxidants are methyl L-ascorbate, ethyl L-ascorbate, propyl L-ascorbate, butyl L-ascorbate, pentyl L-ascorbate, L-ascorbic acid-2-palmitate, L-ascorbic acid-2 -Isopalmitate, L-ascorbic acid-2-stearate, L-ascorbic acid-2-isostearate, L-ascorbic acid-6-palmitate, L-ascorbic acid-6 isopalmitate, L-ascorbic acid-6-stearate L-ascorbic acid-6-isostearate, L-ascorbic acid-2,6-dipalmitate, L-ascorbic acid-2,6-diisopalmitate, L-ascorbic acid-2,6-distearate, L- Ascorbic acid-2,6-diisostearate, L-ascorbine 2-glucoside-6-palmitate, L-ascorbic acid-2-glucoside-6-isopalmitate, L-ascorbic acid-2-glucoside-6-stearate, L-ascorbic acid-2-glucoside-6-isostearate L-ascorbic acid-2-glucoside-6-tocopheryl, L-ascorbic acid-2-sulfuric acid-6-palmitate, L-ascorbic acid-2-sulfuric acid-6-isopalmitate, L-ascorbic acid-2-sulfuric acid-6 -Stearate, L-ascorbic acid-2-sulfuric acid-6-isostearate, L-ascorbic acid-2-sulfuric acid-6-tocopheryl, L-ascorbic acid-2-maleic acid-6-palmitate, L-ascorbic acid 2-maleic acid-6-isopalmitate, L-ascorbic acid-2-maleic acid-6-ste , L-ascorbic acid-2-maleic acid-6-isostearate, L-ascorbic acid-2-maleic acid-6-tocopheryl, L-ascorbic acid-2-phosphate-6-palmitate, L-ascorbic acid 2-phosphate-6-isopalmitate, L-ascorbic acid-2-phosphate-6-stearate, L-ascorbic acid-2-phosphate-6-isostearate, L-ascorbic acid-2-phosphate -6-tocopheryl, palmitoyl 2-0-L-ascorbic acid, isopalmitoyl 2-0-L-ascorbic acid phosphate, stearyl 2-0-L-ascorbic acid phosphate, isostearyl 2-0-L-ascorbic acid Phosphoric acid, tocopheryl 2-0-L-ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl phosphorus 1 to 6 selected from acid, tocotrienol phosphate, tocopheryl glucoside, tocopheryl sulfate, tocopheryl dimethyl glycine, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate, retinoyl dimethyl glycine Cosmetic or skin external preparation as described in any one of these.   Liquid matrix is glycerin, polyhydric alcohol, ethanol, propanol, isopropanol, gelling agent, glycerin, methyl laurate, lauryl alcohol, glycerol monolaurate, oleic acid, oleyl alcohol, glycerol monooleate, glycerol dioleate and triolein Glycerol acid, nicotinic acid, 2-pyrazinecarboxylic acid, sinapinic acid (3,5-dimethoxy-4-hydroxycinnamic acid), 2,5-dihydroxybenzoic acid, 5-methoxysalicylic acid, α-cyano-4-hydroxysilicic acid Cinnamic acid, 3-hydroxypicolinic acid, diaminonaphthalene, 2- (4-hydroxyphenylazo) benzoic acid, disranol, succinic acid, 5- (trifluoromethyl) uracil, propylene glycol, dipropylene glycol Selected from coal, polypropylene glycol, glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, polyethylene glycol, 1,3-butanediol, sorbitol, maltitol, erythritol, pentaerythritol, glucose, saccharose, maltose, xylose, trehalose The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the cosmetic or external preparation is one or more.   Fat-soluble substances are ascorbic acid isopalmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid tetrahexyldecanoic acid, ascorbic acid-6-palmitate, ascorbic acid -2,6-dipalmitate, ascorbic acid-6-stearate, retinol, retinoic acid, retinol palmitate, tocopheryl retinoate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, astaxanthin, lutein, Lycopene, β-carotene, α-carotene, α-tocopherol, β-tocopherol, γ-tocopherol, dimethylglycine tocopherol, ubiquinone, coenzyme A, tocotrienol, Minera Oil, liquid paraffin, squalane, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, 2-ethylhexanoic acid Cetyl, sunflower oil, olive oil, jojoba oil, camellia oil, grape seed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, pycnogenol, coenzyme A, iris extract oil, ashitaba Extraction oil, Asunaro extraction oil, Asparagus extraction oil, Avocado extraction oil, Achacha extraction oil, Almond extraction oil, Altea extraction oil, Arnica extraction oil, A D extraction oil, apricot extraction oil, apricot kernel extraction oil, ginkgo biloba extraction oil, inch ginger extraction oil, fennel extraction oil, turmeric extraction oil, oolong tea extraction oil, walnut extraction oil, ages extraction oil, Echinacea leaf extraction oil, hemlock extract oil, Ougon extract oil, Oat extract oil, Oren extract oil, Barley extract oil, Ginseng extract oil, Hypericum extract oil, Oyster extract oil, Onionis extract oil, Dutch mustard extract oil, Orange extract oil, Seawater dried product, Seaweed extract oil, Oyster Leaf extract oil, oyster extract oil, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cuckoo extract oil, chamomile extract oil, carrot extract oil, kawara mugwort extract oy , Oat extract oil, calcade extract oil, licorice extract oil, oil-soluble licorice extract oil, kiwi extract oil, kiou extract oil, jellyfish extract oil, quinoa extract oil, cucumber extract oil, giraffe leaf extract oil, guanosine, guava extract oil, Kujin Extract Oil, Gardenia Extract Oil, Kumaza Extract Oil, Clara Extract Oil, Walnut Extract Oil, Chestnut Extract Oil, Grapefruit Extract Oil, Clematis Extract Oil, Black Rice Extract Oil, Fat Soluble Brown Sugar Extract, Fat Soluble Black Vinegar Extract, Chlorella extract oil, mulberry extract oil, gentian extract oil, ginger extract oil, black tea extract oil, yeast extract oil, kokuboku extract oil, coffee extract oil, burdock extract oil, rice extract oil, rice fermentation extract oil, rice Nuka Fermentation Extract Oil, Rice Germ Oil, Comfrey Extract Oil, Collagen, Cowberry Extract Oil, Saicin Extract Oil, Psycho Extract Oil, Saitai Extract Liquid, Saffron Extract Oil, Salvia Extract Oil, Soap Extract Oil, Sasa Extract Oil, Hawthorn Extract Oil, Sansha Extract Oil, Salamander Extract Oil, Shiitake Extract Oil, Giant Extract Oil, Sicon Extract Oil, Perilla Extract Oil, Linden Extract Oil, Citrus Extract Oil, Jatoba Extract Oil, Peonies Extract Oil, Ginger Extract Oil, Ginger Root Extraction oil, birch extract oil, white jellyfish extract oil, horsetail extract oil, stevia extract oil, stevia fermented product, Nishikawayanagi extract oil, kizuta extract oil, hawthorn extract oil, elderflower Extraction oil, Achillea millet extract oil, Prunus mint extract oil, Sage extract oil, Zenia mushroom extract oil, Senkyu extract oil, Assembly extract oil, Sakuha extract oil, Daio extract oil, Soy extract oil, Tiso extract oil, Thyme extract oil, Dandelion Extraction oil, lichen extraction oil, tea extraction oil, clove extraction oil, chigaya extraction oil, chimpi extraction oil, tea tree oil, strawberry tea extraction oil, red pepper extraction oil, spruce extraction oil, spruce extract oil, spruce extraction oil, spruce extraction Oil, Dokudami Extract Oil, Tomato Extract Oil, Natto Extract Oil, Carrot Extract Oil, Garlic Extract Oil, Novara Extract Oil, Hibiscus Extract Oil, Bacmond Extract Oil, Lotus Extract Oil Oil, parsley extract oil, birch extract oil, honey, clam extract oil, parietalia extract oil, toad extract, bisabolol, hinoki extract oil, bifidobacteria extract oil, loquat extract oil, dandelion extract oil, fukinotou extract oil, beakryo extract oil , Butcher bloom extract oil, grape extract oil, grape seed extract oil, propolis, loofah extract oil, safflower extract oil, peppermint extract oil, bodaiju extract oil, button extract oil, hop extract oil, micaika extract oil, pine extract oil, maronier Extraction oil, Citrus extract oil, Mukuroji extract oil, Melissa extract oil, Mozuku extract oil, Peach extract oil, Cornflower extract oil, Eucalyptus extract oil, Yukinoshita Extraction oil, Yuzu extraction oil, Lily extraction oil, Yokuinin extraction oil, Artemisia extraction oil, Lavender extraction oil, Green tea extraction oil, Egg shell membrane extraction oil, Apple extraction oil, Rooibos tea extraction oil, Reishi extraction oil, Lettuce extraction oil, Lemon Extraction oil, Forsythia extract oil, Forsythia extract oil, Rose extraction oil, Rosemary extraction oil, Roman chamomile extraction oil, Royal jelly extraction oil, Walnut extract oil, Octamethyltrisiloxane, Decamethyltetrasiloxane, Methylpolysiloxane, Highly polymerized methyl Dimethyl silicone oil such as polysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, methylpolysiloxane It is 1 type, or 2 or more types selected from cyclic silicone oils, such as cyclosiloxane; methyl phenyl silicone oils, such as polyether modified silicone oil and methylphenyl polysiloxane. Cosmetic or topical skin preparation.   High molecular carboxylates include polyacrylic acid, acrylic resins such as acrylic acid-acrylonitrile copolymer, potassium acrylate-acrylonitrile copolymer, vinyl acetate-acrylic ester copolymer and acrylic acid-alkyl acrylate copolymer, styrene-acrylic Styrene such as acid copolymers, styrene-methacrylic acid copolymers, styrene-methacrylic acid-acrylic acid alkyl ester copolymers, styrene-α-methylstyrene-acrylic acid copolymers and styrene-α-methylstyrene-acrylic acid-acrylic acid alkyl ester copolymers. Acrylic resin; styrene-maleic acid copolymer, styrene-maleic anhydride copolymer; vinylnaphthalene-acrylic acid copolymer, vinyl acetate-ethylene copolymer Selected from vinyl acetate resins such as vinyl acetate-fatty acid vinyl ethylene copolymers, vinyl acetate-maleic ester copolymers, vinyl oxalate-crotonic acid copolymers and vinyl acetate-acrylic acid copolymers; and any polyester or cellulose polymer salt The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein the cosmetic or external preparation is one or more.   Additives include hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorinated oils, ozokerite, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, poly Hydrocarbons such as isobutylene, microcrystalline wax, petrolatum, beeswax, carnauba wax, candelilla wax, waxes such as whale wax, beef tallow, beef leg fat, beef bone fat, hard beef fat, hard oil, turtle oil, pork fat, Animal oil such as horse fat, mink oil, liver oil, egg yolk oil, lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, lanolin fatty acid isopropyl, phospholipid, phosphadylcholine, POE lanolin alcohol ether, POE lanolin alcohol Acetate, lanolin fat Lanolin derivatives such as acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid, arachidonic acid, eicosapentaenoic acid (EPA), docosahexaene Fatty acids such as acid (DHA), isostearic acid, 12-hydroxystearic acid, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldodecanol, octyldodecanol Nord, cetostearyl alcohol-2-decyltetradecinol, cholesterol, phytosterol, sitosterol, lanosterol POE cholesterol ether, higher alcohols such as monostearyl glycerin ether (batyl alcohol), diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, Trimethylolpropane triisostearate, ethylene glycol-2-ethylhexanoate-2-ethylhexanoate cetyl tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyl Dodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethyl succinate Tylhexyl, amyl acetate, ethyl acetate, butyl acetate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, palmitic acid 2 -Hexyldecyl, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearylate, dipentaerythritol fatty acid ester, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate , Ethyl laurate, hexyl laurate, N-lauroyl-L-glutamic acid 2-octyldodecyl ester, diisostearyl malate, etc. Oil, acetoglyceride, triisooctanoic acid glyceride, triisostearic acid glyceride, triisopalmitic acid glyceride, tri-2-ethylhexanoic acid glyceride, monostearic acid glyceride, di-2-heptylundecanoic acid glyceride, trimyristic acid glyceride, etc. Glyceride oil, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, stearoxy silicone, etc. Higher alkoxy-modified silicone, higher fatty acid-modified silicone, silicone resin, silicone rubber, silicone resin The cosmetic according to any one of claims 1 to 6, wherein the cosmetic is one or more selected from fluorine oils such as silicone oil, perfluoropolyether, perfluorodecalin, and perfluorooctane. Or skin external preparation.   Metal soap is 12-hydroxy aluminum stearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate, zinc sodium cetyl phosphate, zinc laurate, The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is one or more selected from zinc undecylenate.   The types of cosmetics or skin external preparations are shampoo, oil shampoo, cream shampoo, conditioning shampoo, dandruff shampoo, hair color shampoo, rinse integrated shampoo, rinse, treatment, hair pack, hair foam, hair mousse, hair spray, Hairist, hair wax, hair gel, water grease, set lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow, split hair coat, hair oil, permanent wave agent, straight permanent agent, oxidative hair dye , Hair bleach, hair color pre-treatment, hair color after-treatment, perm pre-treatment, perm after-treatment, hair manicure, hair restorer Cleansing foam, cleansing foam, washing powder, face washing powder, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, lotion, soft lotion, astringent lotion, cleansing lotion Multi-layer lotion, emulsion, emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizer emulsion, massage lotion, cleansing lotion, protect emulsion, sun protect, sun protector, UV care Milk, sunscreen, makeup lotion, horny smoother, elbow lotion, hand lotion, body lotion, cream, emollier Cream, Nutrition Cream, Nourishing Cream, Vanishing Cream, Moisture Cream, Night Cream, Massage Cream, Cleansing Cream, Makeup Cream, Base Cream, Premakeup Cream, Sunscreen Cream, Suntan Cream, Hair Removal Cream, Deodorant Cream, Shaving Cream, keratin softening cream, gel, cleansing gel, moisture gel, soap, cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap, pack, mask, peel-off pack, powder pack, washing pack, oil pack , Cleansing Mask, Essence, Moisturizing Essence, Whitening Essence, UV Protection Essence, Liposome Essence, Liposome Lotion Makeup cosmetics: Makeup cosmetics selected from white powder, dusting powder, foundations, makeup base, lipsticks, lip gloss, blushers, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, nail treatment; Aromatic cosmetics selected from perfume, perfume, parfum, eau de parfum, eau de toilette, eau de cologne, perfume, aromatic powder, perfume soap, body lotion, bath oil; body shampoo, body cleanser, body powder, deodorant lotion, deodorant powder, deodorant Body cosmetics selected from sprays, deodorant sticks, deodorant cosmetics, depigmenting agents, depilation / hair removal agents, bath preparations, insect repellent sprays, insectopellers; ointments, patches, lotions, linime DOO agents, cosmetic or skin external preparation according to any one of claims 1 to 6 is any one selected from a liquid coating agent.   The cosmetic or skin external preparation has an emulsion type such as an oil-in-water (O / W) type, a water-in-oil (W / O) type, a W / O / W type, or an O / W / O type. Molecular type, oily, solid, liquid, kneaded, stick, volatile oil, powder, jelly, gel, paste, cream, sheet, film, mist, spray, multilayer, The cosmetic or external preparation for skin according to any one of claims 1 to 6, which is any one selected from foam and flakes.   Whitening, melanin production inhibition, antioxidant, anti-inflammatory / anti-allergy, active oxygen removal, anti-aging, bactericidal / antibacterial, anti-acne, anti-ultraviolet, hair growth, hair growth, white hair inhibition, hair restoration, sebum inhibition, blood circulation promotion, wound Having at least one of healing promotion, skin metabolism promotion, skin roughening improvement, wrinkle improvement, moisturizing, skin protection, deodorization, antiperspirant, deodorant, astringent, normalization of skin turnover as an effect The cosmetic or external preparation for skin according to any one of claims 1 to 6, wherein