WO2016031079A1

WO2016031079A1 - Phenylethylamine-derivative- or synephrine-containing adenosine triphosphate phosphatase expression inducer

Info

Publication number: WO2016031079A1
Application number: PCT/JP2014/072965
Authority: WO
Inventors: 晃明桝谷; 伊藤　賢一
Original assignee: 一丸ファルコス株式会社
Priority date: 2014-08-28
Filing date: 2014-09-02
Publication date: 2016-03-03
Also published as: JP2016047806A

Abstract

　The problem of the present invention is to make it possible to provide a novel, useful adenosine triphosphate phosphatase expression inducer and a cosmetic composition depending on an adenosine triphosphate phosphatase expression-inducing effect, and to make it possible to provide a phenylethylamine-derivative- or synephrine-containing adenosine triphosphate phosphatase expression inducer and a cosmetic composition depending on an adenosine triphosphate phosphatase expression-inducing effect of a phenylethylamine derivative or synephrine.　

Description

Phenylethylamine derivative or synephrine-containing adenosine triphosphate phosphatase expression inducer

The present invention relates to an adenosine triphosphate phosphatase expression inducer containing a phenylethylamine derivative or synephrine, or a cosmetic composition characterized by having an adenosine triphosphate phosphatase expression inducing action.

Skin and scalp, due to age-related aging, etc., decrease in skin barrier function, skin epidermis function, skin wrinkle formation, reduction in skin tension and gloss, rough skin, or scalp thinning or hair loss It is said to cause etc.

Various components have been used for the purpose of improving the aging phenomenon of the skin and scalp as described above. As typical components, for example, hyaluronic acid, chondroitin tetrasulfate and soluble collagen are used as skin cosmetics (Patent Document 1). Pepper, licorice, dragonfly, peonies, peonies, buttonpis, yokuinin, peony, horseshoe flea, bowfish, chimpi, gentian pepper, dragonfly, tiso, tuna, euphorbia, Arnica, ginseng, peony, A moisturizing cosmetic composition (Patent Document 2) containing at least one kind of extract from Zhuzhou, Zhangzhou, and Shazenshi is already known.

JP 54-52733 A JP 60-258104 A

Moreover, as thinning hair and hair loss of the scalp or hair nourishing / hair growth agent, for example, jaundice extract and its combination component (blood circulation promoter: assembly extract, carrot extract, ginkgo biloba extract, vitamin E and its derivatives, cephalanthin, Minoxidil, carpronium chloride and phthalides, antibacterial agents: octopirox, benzalkonium chloride, zinc pyrithione, salicylic acid and isopropylmethylphenol) are known for hair restoration (patent document 3), and mandarin orange extract It is used for hair nourishing and hair restoration (Patent Document 4).

JP-A-8-73325 JP-A-3-284614

Looking for the above-mentioned causes and related mechanisms of skin and scalp aging, it has been found that induction of adenosine triphosphate phosphatase expression is related to cell adhesion of the skin and scalp. (Non-Patent Document 1).

Adenosine triphosphate phosphatase (hereinafter abbreviated as ATPase) is a general term for a group of hydrolases that hydrolyze terminal high energy phosphate bonds of adenosine triphosphate (hereinafter abbreviated as ATP). The material is actively transported like a pump against the electrochemical gradient inside and outside the membrane. Ca ²⁺ -ATPase is present in the cell membrane, endoplasmic reticulum, and Golgi apparatus, and Ca ²⁺ released into the cytoplasm is returned to the endoplasmic reticulum and Golgi apparatus by Ca ²⁺ -ATPase.
ATPase, Ca ++ transporting, cardiac muscle, slow twitch 2 (hereinafter abbreviated as ATP2A2) and ATPase, Ca ++ Transporting, Type 2C, Member 1 (hereinafter abbreviated as ATP2C1) are genes encoding Ca ²⁺ -ATPase ATP2A2 is expressed in the endoplasmic reticulum membrane, and ATP2C1 is expressed in the Golgi membrane. Ultraviolet rays and inflammation are the main stresses in the skin and scalp, and are deeply related to reduced skin barrier function, reduced skin epidermal function, skin wrinkle formation, reduced skin tension and gloss, and rough skin. It has been reported. In recent years, it has been reported that the expression levels of ATP2A2 and ATP2C1 decrease due to ultraviolet rays and inflammation. Ca ²⁺ -ATPase is thought to be deeply involved in skin homeostasis, such as reduced skin barrier function, reduced skin epidermal function, skin wrinkle formation, reduced skin tension and gloss, and rough skin It is said that this may be prevented (Non-patent Document 2).

So far, there is currently no cosmetic composition (skin or hair cosmetic) that induces the expression of adenosine triphosphate phosphatase related to the adhesion of cells of the skin or scalp.

Therefore, an object of the present invention is to provide a novel and useful substance that induces expression of adenosine triphosphate phosphatase or a substance that induces expression of adenosine triphosphate phosphatase as a cosmetic composition.

Based on the above findings, the present inventor has conducted extensive studies on the theme of excellent natural substances that induce the expression of adenosine triphosphate phosphatase.

As a result, the present inventors have found that it has an action of inducing the expression of adenosine triphosphate phosphatase excellent in phenylethylamine derivatives or synephrine. The present invention provides an adenosine triphosphate phosphatase expression inducer containing a phenylethylamine derivative or synephrine, and further provides a cosmetic composition having the phenylethylamine derivative or synephrine expression inducing action of adenosine triphosphate phosphatase. It came to complete.

It is the figure which evaluated the expression level of ATP2A2 when the synephrine of this invention was added using normal human epidermal keratinocytes (Kurashikibo Co., Ltd. product). As a control (comparison control), a 70% 1,3-butylene glycol aqueous solution as an extraction solvent was prepared under the same conditions and used in the test.

It is the figure which evaluated the expression level of ATP2C1 when the synephrine of this invention was added using normal human epidermal keratinocytes (Kurashikibo Co., Ltd. product). As a control (comparison control), a 70% 1,3-butylene glycol aqueous solution as an extraction solvent was prepared under the same conditions and used in the test.

The “synephrine” used in the present invention is 4- [1-hydroxy-2- (methylamino) ethyl] phenol, chemical formula: C ₉ H ₁₃ NO ₂ , molecular weight: 167.21, and a synthetic product has already been obtained. Although it is marketed, the extract from a natural product can also be used.

The shape of the phenylethylamine derivative or synephrine used in the present invention to be used in producing the adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention is any of liquid, solid, powder, paste, etc. It is possible to select an optimum shape for carrying out the present invention.

The content of the phenylethylamine derivative or synephrine used in the present invention in the adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention is within a range where it can be confirmed that it has an adenosine triphosphate phosphatase expression inducing action. Although there is no particular limitation, it is generally set in the range of 0.01 mg / g to 200 mg / g (the denominator indicates the weight of the preparation). The range is preferably from 0.1 mg / g to 20 mg / g, and most preferably from 200 μg / g to 10 mg / g.

The adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention can be used, for example, in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, Pills, tablets, powders, granules, solids, liquids, gels, bubbles, emulsions, sheets, mists, sprays, etc. in suitable forms for use 1) pharmaceuticals, 2) quasi drugs, 3) topical or Skin cosmetics for the whole body (for example, basic cosmetics such as lotions, emulsions, creams, ointments, lotions, oils, packs, facial cleansers and skin cleansers, massage agents, cleansing agents, hair removers, hair removal Agents, shaving treatments, after-shave lotion, pre-show lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, etc. Makeup cosmetics, perfumes, nail enamels, nail enamels, nail enamel removers, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) Medicated for scalp and hair Or / and cosmetic preparations (for example, shampoos, rinses, hair treatments, pre-hair treatments, permanent liquids, hair dyes, hair styling agents, hair styling agents, hair growth / hair restorers, poultices, plaster agents, Tapes, sheets, patches, aerosols, etc.), 5) bathing agents used in bath water, 6) other anti-odor agents, deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton It can also be used in foods, wet tissues, toothpastes, mouth fresheners, gargles, dishwashing agents, and the like.

The adenosine triphosphate phosphatase expression inducer and cosmetic composition of the present invention include the components and additives exemplified below within the range that does not impair the effects of the present invention, if necessary, in addition to the above essential components. Various preparations can be produced by arbitrarily selecting and using these, and the content in the preparation is not particularly limited, but a concentration range of usually 0.0001 to 50% is preferable.

Examples of oily bases include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, ceralkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, Higher alcohols such as 2-octyldodecanol and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, Palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexene Higher fatty acids such as decanoic acid, antiisohenicosanoic acid, long-chain branched fatty acid, dimer acid, hydrogenated dimer acid, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, sodium salts, potassium salts, etc. And nitrogen-containing derivatives such as ethanolamine salts and amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane , Olive-derived squalane, squalene, petroleum jelly, solid paraffin and other carbides; candelilla wax, carnauba wax, rice wax, waxy wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline Waxes such as palm wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, tea tree oil, mint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil Vegetable oils such as peanut oil, rice bran oil, cacao butter, shea butter, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil; beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle Animal fats such as oil; such as whale wax, lanolin, orange luffy oil Physical waxes: Liquid lanolin, reduced lanolin, adsorbed purified lanolin, lanolin acetate, liquid lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, acetic acid (cetyl lanolyl) ester Lanolins such as: lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phospholipids such as phosphatidic acid, lysolecithin; hydrogenated soybean phospholipid, partially hydrogenated soybean Phospholipids such as phospholipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids; cholesterol, dihydrocholesterol, lanostero , Sterols such as dihydrolanosterol, phytosterol and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, cholesteryl stearate, cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamate di (cholesteryl / behenyl) / Octyldodecyl), N-lauroyl-L-glutamate di (cholesteryl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamate di (phytosteryl / octyldodecyl) ), Acyl sarcosine alkyl esters such as N-lauroyl sarcosine isopropyl, cholesteryl 12-hydroxystearate, macadamia nut oil fatty acid choles Sterol esters such as teryl, macadamia nut oil fatty acid phytosteryl, phytosteryl isostearate, soft lanolin fatty acid cholesteryl, hard lanolin fatty acid cholesteryl, long chain branched fatty acid cholesteryl, long chain α-hydroxy fatty acid cholesteryl; phospholipid / cholesterol complex, phospholipid / Lipid complexes such as phytosterol complex; octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl paritate, octyldodecyl palmitate, cetyl octoate, hexyldecyl octoate, isotridecyl isononanoate, isononanoyl isononanoate, Octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, neopen Isostearyl acid, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, hexyldecyl dimethyloctanoate, octyldodecyl erucate, isostearic acid hydrogenated castor oil, ethyl oleate, Mono-alcohol carboxylic acid esters such as ethyl avocado oil fatty acid, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, lanolin fatty acid isopropyl, triethyl citrate; cetyl lactate, diisostearyl malate, monoisostearic acid water Oxyacid esters such as castor oil; glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, dii Glyceryl sostearate, tri (caprylic acid / capric acid) glyceryl, tri (caprylic acid / capric acid / myristic acid / stearic acid) glyceryl, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), behen Glyceryl acid eicosane diacid, (tetradecanedioic acid / eicosanedioic acid) glyceryl, (tetradecanedioic acid / eicosanedioic acid) polyglyceryl-10, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, neopentyl glycol dioctanoate, dicaprin Neopentyl glycol acid, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, 3-methyl-1,5-pentanediol dineopentanoate, 2,4-diethine dineopentanoate 1,5-pentanediol, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, (tristearic acid / sebacic acid) ditrimethylolpropane, pentaerythrisotriethylhexanoate Lithyl, (hydroxystearic acid / stearic acid / rosinic acid) dipentaerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl nonaisostearate-10, deca (erucic acid / isostearic acid / ricinoleic acid) polyglyceryl-8, (hexyldecanoic acid) / Sebacic acid) Polyglycerides such as diglyceryl oligoester, glycol distearate (ethylene glycol distearate) Fatty acid esters; diisopropyl dimerlinoleate diisopropyl, dimer dilinoleate diisostearyl, dimer dilinoleate di (isostearyl / phytosteryl), dimer dilinoleate (phytosteryl / behenyl), dimer dilinoleate (phytosteryl / isostearyl) / Cetyl / stearyl / behenyl), dimer dilinoleic acid dimer dilinoleyl, dimer dilinoleic acid dimer dilinoleyl bis (phytosteryl / behenyl / isostearyl), diisostearate dimer dilinoleyl, dimer dilinoleyl hydrogenated rosin condensation , Dimer linoleic acid hydrogenated castor oil, dimer acid or dimer diol derivative such as hydroxyalkyl dimer linoleyl ether; coconut oil fatty acid monoethanolamide (komi De MEA), palm oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide) MEA), fatty acid alkanolamides such as palmitic acid diethanolamide (partamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone ( Cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyltrimethicone, diphenyldimethicone, phenyldimethicone, stearoxypropioxy Dimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicone such as aminopropyldimethicone and amodimethicone, cation-modified silicone, polyether modified such as dimethicone copolyol Silicone, polyglycerin modified silicone, sugar modified silicone, carboxylic acid modified silicone, phosphoric acid modified silicone, sulfuric acid modified silicone, alkyl modified silicone, fatty acid modified silicone, alkyl ether modified silicone, amino acid modified silicone, peptide modified silicone, fluorine modified silicone, Cationic and polyether modified silicones, amino and polyether modified silicones, alkyl modified Fine polyether-modified silicone, silicones such as polysiloxane polyoxyalkylene copolymer; perfluorodecane, perfluorooctane, fluorine-based oils such as perfluoropolyether may be mentioned as preferred.

As moisturizers / feel improvers, water (ordinary water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionic water, electrolytic acidic ionic water, ionic water, cluster water) ), Glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol , Hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, polyols such as ethylene glycol / propylene glycol copolymer and polymers thereof; diethylene glycol monoethyl ether (ethoxydiglycol) Glycol alkyl ethers such as ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, diethylene glycol dibutyl ether; sugar alcohols such as sorbitol, xylitol, erythritol, mannitol, maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose , Fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, β-glucan, chitin, chitosan, heparin and derivatives, pectin, arabinogalactan, dextrin, dextran, glycogen, ethyl glucoside, methacrylic Sugars such as glucosylethyl acid polymer or copolymer, and derivatives thereof; hyal Rhonic acid, sodium hyaluronate; chondroitin sulfate sodium; mucoitin sulfate, caroline sulfate, keratosulfate, dermatan sulfate; white jellyfish extract, white jellyfish polysaccharides; fucoidan; polysaccharides such as tubarose polysaccharide; citric acid, tartaric acid, lactic acid Organic acids and salts thereof; urea; salts of 2-pyrrolidone-5-carboxylic acid and sodium thereof; betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, Amino acids such as β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, taurine and salts thereof Collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degrading peptide, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degrading peptide, keratin degrading peptide, hydrolyzed keratin, conchiolin degrading peptide, hydrolyzed conchiolin, silk protein Degraded peptide, hydrolyzed silk, lauroyl hydrolyzed sodium sodium, soybean proteolytic peptide, wheat proteolytic peptide, hydrolyzed wheat protein, casein degrading peptide, acylated peptide, and other peptide peptides; palmitoyl oligopeptide, palmitoyl penta Peptides, acylated peptides such as palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture solution, yeast extract, eggshell membrane protein, bovine submandibular gland Mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, aerustin, collagen, aloe extract, hamamelis water, loofah water, chamomile extract, licorice extract, comfrey extract, silk Extracts, Izayoi rose extract, Achillea millefolium extract, Eucalyptus extract, Merirot extract and other animal / plant extract components, natural ceramide (types 1, 2, 3, 4, 5, 6), hydroxyceramide, pseudoceramide, glycosphingolipid, Ceramides such as ceramide and sugar ceramide-containing extract are preferred.

Preferred examples of the surfactant include an anionic surfactant, a nonionic surfactant, a cationic surfactant, an amphoteric surfactant, and a polymer surfactant. There is no restriction | limiting in particular in HLB of surfactant, It can use from about 1 low thing to about 20 high thing, It is also preferable to combine what has low and high HLB. Examples of preferable surfactants include fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfates such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; laureth Polyoxyethylene alkyl sulfates such as sodium sulfate and laureth sulfate triethanolamine; cocoyl methyl taurine sodium, cocoyl methyl taurine potassium, lauroyl methyl taurine sodium, myristoyl methyl taurine sodium, lauroyl methyl alanine sodium, lauroyl sarcosine sodium, lauroyl sarcosine triethanol Acyl N-methyl amino acid salts such as amine and sodium methylalanine lauroylglutamate; Cocoyl Glue Acyl amino acid salts such as sodium minate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, cocoylalanine triethanolamine; polyoxyethylene alkyl ethers such as sodium laureth acetate Acetic acid salt; Succinic acid ester salt such as sodium lauroyl monoethanolamide succinate; Fatty acid alkanolamide ether carboxylate; Acyl lactate; Polyoxyethylene fatty amine sulfate; Fatty acid alkanolamide sulfate; Hardened coconut oil fatty acid sodium glyceryl sulfate Fatty acid glyceride sulfate such as alkylbenzene polyoxyethylene sulfate; α-olefin Olefin sulfonates such as sodium sulfonate; alkylsulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; disodium laureth sulfosuccinate, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, lauryl polypropylene glycol sulfosuccinic acid Alkyl ether sulfosuccinates such as sodium; alkylbenzene sulfonates such as sodium tetradecylbenzenesulfonate and triethanolamine tetradecylbenzenesulfonate; alkylnaphthalenesulfonates; alkanesulfonates; α-sulfo fatty acid methyl ester salts; Acyl isethionate; alkyl glycidyl ether sulfonate; alkyl sulfoacetate; laurethrin Alkyl ether phosphates such as sodium, sodium dilaureth phosphate, sodium trilaureth phosphate, sodium monooles phosphate; alkyl phosphate salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphate; fatty acid amide ether phosphorus Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; silicone anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; and nonionic surfactants, laureth (Polyoxyethylene lauryl ether), ceteth (polyoxyethylene cetyl ether), steareth (polyoxyethylene stearyl ether), behenez (polyoxyethylene) Nbehenyl ethers), isosteares (polyoxyethylene isostearyl ethers), octyldecesses (polyoxyethylene octyldodecyl ethers) and other polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers; polyoxyethylene alkylphenyl ethers; Polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, poly Castor oil such as oxyethylene hydrogenated castor oil maleic acid and hydrogenated castor oil derivatives; polyoxyethylene phytosterol; polyoxyethylene cholesterol; polyoxy Polyoxyethylene lanolin; Polyoxyethylene reduced lanolin; Polyoxyethylene / polyoxypropylene cetyl ether, Polyoxyethylene / polyoxypropylene 2-decyltetradecyl ether, Polyoxyethylene / polyoxypropylene monobutyl ether, Poly Oxyethylene / polyoxypropylene hydrogenated lanolin, polyoxyethylene / polyoxypropylene alkyl ethers such as polyoxyethylene / polyoxypropylene glycerin ether; polyoxyethylene / polyoxypropylene glycol; (poly) such as PPG-9 diglyceryl Glycerin polyoxypropylene glycol; glyceryl stearate, glyceryl isostearate, glyceryl palmitate, myristate group Glyceryl fatty acid partial esters such as ceryl, glyceryl oleate, glyceryl coconut fatty acid, mono-cotton oil fatty acid glycerin, glyceryl monoerucate, glyceryl sesquioleate, α, α'-oleic acid pyroglutamate glycerin, monostearate glycerin malic acid Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, 10 polyglyceryl distearate-6, 10, polyglyceryl tristearate, polyglyceryl decastearate-10, polyglyceryl isostearate -2, 3, 4, 5, 6, 8, 10, diglycostyl diisostearate (diglyceryl diisostearate), 3, 10, polyglyceryl-2 triisostearate, polyglyceryl tetraisostearate Ril-2, polyglyceryl-10 decaisostearate, polyglyceryl-2 oleate, 3,4, 5,6, 8,8, dioleate polyglyceryl-6, trioleate polyglyceryl-2, dekaoleic acid Polyglyceryl fatty acid esters such as polyglyceryl-10; ethylene glycol monofatty acid esters such as ethylene glycol monostearate; propylene glycol monofatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol moieties Fatty acid ester; maltitol ether; sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monos Sorbitan fatty acid esters such as allate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate; sucrose fatty acid ester, methyl glucoside fatty acid ester, trehalose undecylenate, etc. Partial derivatives of sugar derivatives; alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohols; reduced lanolin; polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, polyoxyethylene di- Polyoxyethylene fatty acid mono- and diesters such as oleate; polyoxyethylene propylene glycol fatty acid ester; polyoxyethylene Polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleate such as polyglycerin monostearate, polyoxyethylene glycerin monoisostearate, polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxy Polyoxyethylene sorbitan fatty acid esters such as ethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan tetraoleate; polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol penta Polyoxyethylene sorbitol fatty acid esters such as oleate and polyoxyethylene sorbitol monostearate Polyoxyethylene methyl glucoside fatty acid ester; Polyoxyethylene alkyl ether fatty acid ester; Polyoxyethylene animal and vegetable oils such as polyoxyethylene sorbitol beeswax; Alkyl such as isostearyl glyceryl ether, chimyl alcohol, ceralkyl alcohol, batyl alcohol Glyceryl ethers; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene / tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponins and sophorolipids; polyoxyethylene fatty acid amides; coconut oil Fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (laura) De-MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (partamide MEA), palmitic acid diethanolamide (partamide DEA), palm oil fatty acid methylethanolamide (cocamidomethyl) Fatty acid alkanolamides such as MEA); alkyldimethylamine oxides such as lauramine oxide, cocamamine oxide, stearamine oxide, and behenamine oxide; alkylethoxydimethylamine oxide; polyoxyethylene alkyl mercaptan; poly such as dimethicone copolyol Silicone such as ether-modified silicone, polysiloxane-oxyalkylene copolymer, polyglycerin-modified silicone, sugar-modified silicone Nonionic surfactants, etc .; for cationic surfactants, alkyltrimethylammonium chlorides such as behentrimonium chloride, steartrimonium chloride, cetrimonium chloride, lauryltrimonium chloride; alkyls such as stearyltrimonium bromide Trialkylammonium bromide; dialkyldimethylammonium chloride such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidepropyldimethylamine and stearamideethyldiethylamine; alkyl ether amines such as stearoxypropyldimethylamine; Salt or quaternary salt thereof; ethyl sulfate long chain branched fatty acid (12-31) aminopropylethyldimethylammonium, ethyl sulfate lanolin fat Fatty acid amide type quaternary ammonium salts such as aminopropylethyldimethylammonium acid; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amidoguanidinium salts; alkyl etheraminemonium salts; Benzalkonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkyl morpholinium salts; polyamine fatty acid derivatives; amino such as aminopropyl dimethicone and amodimethicone Silicone cationic surfactants such as modified silicone, cation modified silicone, cation modified and polyether modified silicone, amino modified and polyether modified silicone, etc .; amphoteric interface Sexual agents include N-alkyl-N, N-dimethylamino acid betaines such as lauryl betaine (lauryldimethylaminoacetic acid betaine); fatty acid amide alkyl-N, N-dimethylamino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; Imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkylsulfobetaines such as alkyldimethyltaurine; sulfate-type betaines such as alkyldimethylaminoethanol sulfate; phosphate-type betaines such as alkyldimethylaminoethanol phosphate; phosphatidylcholine; Sphingophospholipids such as phosphatidylethanolamine, phosphatidylserine, sphingomyelin, lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phosphorus Lipids such as lipids, hydrogenated egg yolk phospholipids, partially hydrogenated egg yolk phospholipids, and hydroxylated lecithin; silicone-based amphoteric surfactants; polymer surfactants such as polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, Preferable examples include acrylic acid / alkyl methacrylate copolymers, 2-methacryloyloxyethyl phosphorylcholine / stearyl methacrylate copolymers, and various silicone surfactants.

Polymers, thickeners and gelling agents include guar gum, locust bean gum, queens seed, carrageenan, galactan, arabic gum, tara gum, tamarind, far selelain, karaya gum, troarooi, cara gum, tragacanth gum, pectin, pectic acid and sodium Salt such as salt, salt such as alginic acid and sodium salt, mannan; starch such as rice, corn, potato, wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and its salt, xanthan gum, pullulan, gellan gum, chitin , Chitosan, agar, gypsophila extract, chondroitin sulfate, casein, collagen, gelatin, albumin; methylcellulose, ethylcellulose, hydroxyethylcellulose, hydroxypro Cellulose, carboxymethylcellulose and its sodium salts, methylhydroxypropylcellulose, sodium cellulose sulfate, cellulose dialkyldimethylammonium sulfate, crystalline cellulose, cellulose powder such as cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch , Starch-based polymers such as methyl starch, starch derivatives such as hydroxypropyltrimonium chloride, octenyl succinic acid corn starch aluminum; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyridone (PVP), polyvinyl alcohol (PVA) , Vinyl pydridone-vinyl alcohol copolymer, polyvinyl methyl ester Ter; polyethylene glycol, polypropylene glycol, polyoxyethylene / polyoxypropylene copolymers; amphoteric methacrylic acid such as (methacryloyloxyethylcarboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine methacrylate oxide) copolymer Ester copolymer; (Dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; Polyvinyl acetate partial saponification product, maleic acid copolymer; Vinylpyrrolidone / dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine; polyester, water-dispersible polyester; poly Acrylamide; Polyacrylic acid ester copolymer such as polyethyl acrylate, carboxyvinyl polymer, polyacrylic acid and its sodium salt, acrylic acid / methacrylic acid ester copolymer; acrylic acid / alkyl methacrylate Polymer: Cationized cellulose such as polyquaternium-10, diallyldimethylammonium chloride / acrylamide copolymer such as polyquaternium-7, acrylic acid / diallyldimethylammonium chloride copolymer such as polyquaternium-22, acrylic acid such as polyquaternium-39・ Diallyldimethylammonium chloride / acrylamide copolymer, acrylic acid / cationized methacrylic acid ester copolymer, acrylic acid / cationized methacrylic acid amide copolymer, polyquatani -47 etc. acrylic acid / methyl acrylate / methacrylamidopropyltrimethylammonium chloride copolymer, methacrylic acid choline ester polymer; cationized polysaccharide such as cationized oligosaccharide, cationized dextran, guar hydroxypropyltrimonium chloride Polyethyleneimine; cationic polymer; 2-methacryloyloxyethyl phosphorylcholine polymer such as polyquaternium-51 and copolymer with butyl methacrylate copolymer; acrylic resin emulsion, polyethyl acrylate emulsion, polyacrylalkyl ester emulsion , Polymer emulsions such as polyvinyl acetate resin emulsion, natural rubber latex, synthetic latex; nitrocellulose; polyurethanes and various copolymers; Various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluoropolymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate and dextrin myristate; silicic anhydride , Fumed silica (ultrafine silica), magnesium magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, bentonite, hectorite, organically modified clay mineral, sucrose fatty acid ester, fructooligosaccharide fatty acid ester Is preferable.

Solvents and propellants include ethanol, 2-propanol (isopropyl alcohol), butanol, isobutyl alcohol and other lower alcohols; propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, isopentyl diol and other glycols Diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, diethylene glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, dipropylene glycol monoethyl ether Glycol ethers such as ethylene glycol monoethyl ether Glycol ether esters such as diacetate, diethylene glycol monoethyl ether acetate, propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate, ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, carbonic acid Preferred examples include dialkyl, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbon, next-generation fluorocarbons; LPG, dimethyl ether, carbon dioxide, and the like.

Antioxidants include α-lipoic acid, salts of α-lipoic acid, and derivatives of α-lipoic acid; tocopherol derivatives such as tocopherol (vitamin E), tocotrienol, tocopherol acetate; BHT, BHA; propyl gallate, etc. Gallic acid derivatives; vitamin C (ascorbic acid) and / or derivatives thereof; erythorbic acid and derivatives thereof; sulfites such as sodium sulfite; bisulfites such as sodium bisulfite; thiosulfates such as sodium thiosulfate; metabisulfite Salts: thiotaurine, hypotaurine; thioglycerol, thiourea, thioglycolic acid, cysteine hydrochloride are preferred. Preferred examples of the reducing agent include thioglycolic acid, cysteine, cysteamine and the like. Preferred examples of the oxidizing agent include aqueous hydrogen peroxide, ammonium persulfate, sodium bromate, and percarbonate.

Antiseptic and antibacterial agents include hydroxybenzoic acid and its salts or esters such as methylparaben, ethylparaben, propylparaben, butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-pentanediol, 1,2-hexane 1,2-diols such as diols; isothiazolinone derivatives such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols such as triclosan, acid amides , Quaternary ammonium salts; trichlorocarbanide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, Nokichioru; phenol, isopropyl phenol, cresol, thymol, p-chlorophenol, phenylphenol, other phenols such as phenylphenol sodium; phenylethyl alcohol, photosensitive Motorui, be mentioned as antibacterial zeolite, silver ion.

Examples of chelating agents include edetate (ethylenediaminetetraacetate) such as EDTA, EDTA2Na, EDTA3Na, and EDTA4Na; hydroxyethylethylenediaminetriacetate such as HEDTA3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; Phosphonic acid and its sodium salt; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine Gluconic acid, ascorbic acid, succinic acid, and tartaric acid are preferable.

pH adjusters / acids / alkalis include citric acid, sodium citrate, lactic acid, sodium lactate, glycolic acid, succinic acid, acetic acid, sodium acetate, malic acid, tartaric acid, fumaric acid, phosphoric acid, hydrochloric acid, sulfuric acid, monoethanol Amine, diethanolamine, triethanolamine, isopropanolamine, triisopropanolamine, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, hydroxylated Sodium, potassium hydroxide, aqueous ammonia, guanidine carbonate, and ammonium carbonate are preferable.

Examples of powders include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, red mica, biotite, permiculite, magnesium carbonate, calcium carbonate, aluminum silicate, silica Barium acid, calcium silicate, magnesium silicate, strontium silicate, metal tungstate, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorine apatite, hydroxyapatite, ceramic powder, bentonite, smectite, clay, mud, Metal soap (for example, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, bengara, yellow iron oxide, black iron oxide, ultramarine, bitumen, carbon black, titanium oxide, fine particles and super Titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silica), mica titanium, fish scale foil, boron nitride, photochromic pigment, synthetic fluorophlogopite, fine particle composite powder Body, gold, aluminum, etc., various sizes and shapes of inorganic powders, and these are treated with various surface treatment agents such as hydrogen silicone, cyclic hydrogen silicone, or other silane or titanium coupling agents Inorganic powders such as hydrophobized or hydrophilized powders; starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, copolymer resin powder of styrene and acrylic acid, polyester powder, Benzoguanamine resin powder, polyethylene terephthalate, polymethy Organic powders and surface-treated powders of various sizes and shapes, such as polyurethane powder, polyethylene terephthalate / aluminum / epoxy powder, urethane powder, silicone powder, Teflon (registered trademark) powder, organic-inorganic composite powder The body is preferred. Inorganic salts include sodium chloride-containing salts such as salt, common salt, rock salt, sea salt, natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, Aluminum sulfate / potassium sulfate (alum), aluminum sulfate / ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, copper sulfate; sodium phosphates such as 1Na, 2Na and 3Na phosphates, phosphoric acid Potassium, calcium phosphates and magnesium phosphates are preferred.

Examples of ultraviolet absorbers include paraaminobenzoic acid, paraaminobenzoic acid monoglycerin ester, N, N-dipropoxyparaaminobenzoic acid ethyl ester, N, N-diethoxyparaaminobenzoic acid ethyl ester, and N, N-dimethylparaaminobenzoic acid ethyl ester. Benzoic acid ultraviolet absorbers such as esters, N, N-dimethylparaaminobenzoic acid butyl ester, N, N-dimethylparaaminobenzoic acid ethyl ester; Anthranilic acid ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; Salicylic acid And salicylic acid systems such as sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, p-isopropanol phenyl salicylate External line absorbent: octyl cinnamate, ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p- Methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl p-methoxycinnamate (octyl paramethoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (sinoxate), Cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl α-cyano-β-phenylcinnamate (octocrine), glyceryl mono-2-ethylhexanoyl-diparamethoxy Cinnamic acid UV absorbers such as nanmate, ferulic acid and derivatives thereof; 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2 ′, 4,4′-tetrahydroxybenzophenone, 2-hydroxy-4-methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4′-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone -5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone, etc. Benzophenone series External line absorber; 3- (4′-methylbenzylidene) -d, l-camphor, 3-benzylidene-d, l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2′-hydroxy-5- 2- (2′-hydroxy-5′-t-octylphenyl) benzotriazole; 2- (2′-hydroxy-5′-methylphenylbenzotriazole; dibenzalazine; dianisoylmethane; 5- (3 , 3-dimethyl-2-norbornylidene) -3-pentan-2-one; dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane; octyl triazone; urocanic acid derivatives such as urocanic acid and ethyl urocanate; 2- (2′-hydroxy-5′-methylphenyl) benzotriazole, 1- 3,4-dimethoxyphenyl) -4,4-dimethyl-1,3-pentanedione, dimethoxybenzylidenedioxoimidazolidinepropionate 2-ethylhexyl, etc. hydantoin derivatives, phenylbenzimidazolazosulfonic acid, terephthalylidene dicamphor Preferred are sulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and derivatives thereof, oryzanol and derivatives thereof.

As whitening agents, ascorbic acid, ascorbic acid phosphate sodium salt such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, ascorbic acid fatty acid ester such as ascorbic acid tetraisopalmitate, ascorbic acid ethyl ether Ascorbic acid alkyl ethers such as ascorbic acid glucosides such as ascorbic acid-2-glucoside and fatty acid esters thereof, ascorbic acid sulfates, ascorbic acid derivatives such as tocopheryl phosphate ascorbyl; kojic acid, ellagic acid, tranexamic acid and the like Derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butyl resorcinol, oil-soluble chamomile extract, oil-soluble licorice extract, Nishikawayanagi Eki , It is mentioned as saxifrage extract, and the like plant extracts are preferred.

Vitamins and their derivatives include vitamin A such as retinol, retinol acetate, retinol palmitate; thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, Flavin adenine dinucleotide, cyanocobalamin, folic acid, nicotinic acid such as nicotinic acid amide / benzyl nicotinate, vitamin B group such as choline; vitamin C such as ascorbic acid and its sodium salt; vitamin D; α, Vitamin E such as β, γ, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphates such as ascorbic acid phosphate sodium salt and ascorbic acid phosphate magnesium salt, Ascorbic acid fatty acid esters such as ascorbyl tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucosides such as ascorbic acid-2-glucoside and Ascorbic acid derivatives such as fatty acid esters and tocopheryl phosphate ascorbyl; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol acetate, tocopherol linoleate, tocopherol phosphate, tocopherol phosphate etc., tocotrienol, and other various vitamin derivatives Is preferable.

Anti-inflammatory and anti-inflammatory agents include glycyrrhizic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, chlorpheniramine maleate; peach leaf extract A plant extract such as a koji leaf extract is preferable.

Plant growth and tinctures such as assembly extract, red pepper tincture, ginger tincture, ginger extract, cantalis tincture; capsaicin, nonyl acid valenylamide, gingeron, ictamol, tannic acid Borneol, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, cephalanthin, γ-oryzanol, cephalanthin, vitamin E and derivatives such as tocopherol / nicotinic acid tocopherol, γ-oryzanol, nicotinic acid and nicotinamide / benzyl nicotinate Derivatives such as ester, inositol hexanicotinate, nicotine alcohol, allantoin, photosensitive element 301, photosensitive element 401, capronium chloride, pentadecanoic acid monoglyceride Flavonol derivatives, stigmasterol or stigmasteranol and its glycosides, and minoxidil are preferable.

Preferred examples of hormones include estradiol, estrone, ethinyl estradiol, cortisone, hydrocortisone, prednisone and the like.

Other remedies such as anti-wrinkle agents, anti-aging agents, squeeze agents, cooling sensations, warming sensation agents, wound healing promoters, irritation relievers, analgesics, cell activators include retinols, retinoic acids, retinoin Acid tocopheryl; derivatives such as lactic acid, glycolic acid, gluconic acid, fruit acid, salicylic acid and glycosides / esterified products thereof, α- or such as hydroxycapric acid, long chain α-hydroxy fatty acid, long chain α-hydroxy fatty acid cholesteryl β-hydroxy acids and derivatives thereof; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; carnosine; creatine; ceramides, sphingosines; caffeine, xanthine and the like; coenzyme Q10, carotene, lycopene , Astaxanthin, lutein and other antioxidant / active oxygen scavengers; catechins; Flavones such as tin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidins, chlorogenic acid, apple polyphenol; derivatives such as rutin and glycosides; lignan glycosides; Licorice extract related substances such as liquiritin and isoliquiritin; lactoferrin; gingerol; fragrance substances such as menthol, camphor and cedrol and derivatives thereof; capsaicin, vanillin and other derivatives; insect repellents such as diethyltoluamide; physiologically active substances And a complex of cyclodextrins is preferred.

Plant / animal / microbe extracts include iris extract, ashitaba extract, asunalo extract, asparagus extract, avocado extract, achacha extract, almond extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract , Incheon extract, Fennel extract, Turmeric extract, Oolong tea extract, Peony extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Odori extract , Dutch mustard extract, dried sea water, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, braces Extract, chamomile extract, oil-soluble chamomile extract, carrot extract, kawara-momogi extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quina extract, cucumber extract, giraffe leaf extract, guanosine, guava Extract, Kujin Extract, Gardenia Extract, Kumazasa Extract, Clara Extract, Walnut Extract, Chestnut Extract, Grapefruit Extract, Clematis Extract, Black Rice Extract, Brown Sugar Extract, Black Vinegar, Chlorella Extract, Mulberry Extract, Gentianana Extract, Gennoshoco Extract, Black Tea Extract, Yeast Extract, kokuboku extract, coffee extract, burdock extract, rice extract, fermented rice extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, koji Peach extract, Saishin extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Sabon extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimotake extract, Jatoba extract , Peonies extract, Pepper extract, Pepper root extract, White birch extract, White jellyfish extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Horseshoe extract, Hawthorn extract, Horseshoe extract, Achillea millefolium extract Extract, sage extract, mallow extract, nematode extract, assembly extract, Sou Hakuhi extract, Daio extract, soybean extract, Thailand Saw extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, chigaya extract, tea tree oil, strawberry tea extract, red pepper extract, touki extract, tofu extract, tonin extract, dokudami extract, tomato extract, natto extract, carrot extract, Garlic extract, Novara extract, Hibiscus extract, Bacmond extract, Lotus extract, Parsley extract, Birch extract, Honey, Hamamelis extract, Parietalia extract, Toad extract, Bisabolol, Hinoki extract, Bifidobacteria extract, Biwa extract, Japanese dandelion extract, Fukinoto extract Bukuryo extract, butcher bloom extract, grape extract, grape seed extract, propolis, loofah extract, safflower extract, peppermint extract, body Extract, button extract, hop extract, cocoon extract, pine extract, maronier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, yokoinin extract, mugwort extract, Lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, bitumen extract, etc. An extract is mentioned as a preferable thing.

Examples of antipruritic agents include diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, substance-P inhibitor and the like. Examples of the exfoliating / dissolving agent include salicylic acid, sulfur, resorcin, selenium sulfide, pyridoxine and the like. Examples of the antiperspirant include chlorohydroxyaluminum, aluminum chloride, zinc oxide, and zinc paraphenol sulfonate. Examples of the refreshing agent include menthol and methyl salicylate. Examples of the astringent include citric acid, tartaric acid, lactic acid, aluminum sulfate / potassium sulfate, and tannic acid. Examples of enzymes include superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, protease, and the like. Preferred nucleic acids include ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

As perfumes, acetyl cedrene, amylcinnamaldehyde, allyl amyl glycolate, β-ionone, iso-Esuper, isobutyl quinoline, Iris oil, Iron, indole, ylang ylang oil, undecanal, undecenal, γ-undecalactone, Estragole, Eugenol, Oak Moss, Opoponax Resinoid, Orange Oil, Eugenol, Auranthiol, Galac Solid, Carvacrol, L-Carbon, Camphor, Cannon, Carrot Seed Oil, Clove Oil, Methyl Cinrate, Geraniol, Geraniol Nitrile , Isobornyl acetate, geranyl acetate, dimethylbenzyl carvinyl acetate, styrylyl acetate, cedolyl acetate, terpinel acetate, pt-butylcyclohexyl acetate, vetiberyl acetate, benzyl acetate, Linalyl acid, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamenaldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrsenol, jasmine absolute, jasmine lactone, cis-jasmon, citral, citronenol, citronellal , Cinnamon bark oil, 1,8-cineole, cinnamaldehyde, stylux resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascon, damassenone, thymol, tuberose absolute, decanal, decalactone, terpineol, γ-terpinene , Tripral, Nerol, Nonanal, 2,6-Nonadienol, Nonalactone, Patchouli alcohol, Vanilla absolute, Vanill , Basil oil, patchouli oil, hydroxycitronellal, α-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitglen oil, hexylcinnamaldehyde, cis-3-hexenol, perubalsum, vetiver oil, vetiverol, peppermint oil, pepper oil , Heliotropin, bergamot oil, benzylbenzoate, borneol, milresinoid, musk ketone, methylnonylacetaldehyde, γ-methylyonone, menthol, L-menthol, L-menton, eucalyptus oil, β-yonone, lime oil, lavender oil, D- Synthetic and natural fragrances such as limonene, linalool, rillar, rigliall, lemon oil, rose absolute, rose oxide, rose oil, rosemary oil, various essential oils, and various blended fragrances are preferred. And the like as objects.

As pigments / colorants / dyes / pigments, brown 201, black 401, purple 201, purple 401, blue 1, blue 2, blue 201, blue 202, blue 203, blue 204 , Blue 205, Blue 403, Blue 404, Green 201, Green 202, Green 204, Green 205, Green 3, Green 401, Green 402, Red 102, Red 104-1 Red 105-1, Red 106, Red 2, Red 201, Red 202, Red 203, Red 204, Red 205, Red 206, Red 207, Red 208, Red 213 Red 214, Red 215, Red 218, Red 219, Red 220, Red 221, Red 223, Red 225, Red 226, Red 227, Red 228, Red 23 No.-1, Red 230-2, Red 231, Red 232, Red 3, Red 401, Red 404, Red 405, Red 501, Red 502, Red 503, Red 504, Red 505, Red 506, Orange 201, Orange 203, Orange 204, Orange 205, Orange 206, Orange 207, Orange 401, Orange 402, Orange 403, Yellow 201, Yellow 202 -1, Yellow 202-2, Yellow 203, Yellow 204, Yellow 205, Yellow 4, Yellow 401, Yellow 402, Yellow 403-1, Yellow 404, Yellow 405, Yellow 406 No., Yellow 407, Yellow 5 etc .; other acid dyes such as Acid Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, nitro dyes such as HC Red 3, 4-hydoxypropylamino-3-nitrophenol, N, N'-bis (2-hydroxyethyl) -2-nitro-p-phenylenediamine, HC Blue 2, Basic Blue 26; disperse dyes; dioxide Inorganic white pigments such as titanium and zinc oxide; Inorganic red pigments such as iron oxide (Bengara) and iron titanate; Inorganic brown pigments such as γ-iron oxide; Inorganic yellow pigments such as yellow iron oxide and loess; Black Inorganic black pigments such as iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet; inorganic green pigments such as chromium oxide, chromium hydroxide and cobalt titanate; inorganic blue pigments such as ultramarine and bitumen Pigments: titanium oxide coated mica, titanium oxide coated bismuth oxychloride, titanium oxide coated talc, colored titanium oxide coated mica, bismuth oxychloride, fish scale foil, etc .; aluminum powder, copper powder Metal powder pigments such as gold and gold; surface-treated inorganic and metal powder pigments; red 201, red 202, red 204, red 205, red 220, red 226, red 228, red 405, orange No. 203, Orange No. 204, Yellow No. 205, Yellow No. 401, Blue No. 404, Red No. 3, Red No. 104, Red No. 106, Red No. 227, Red No. 230, Red No. 401, Red No. 505, Orange No. 205 Organic pigments such as zirconium, barium or aluminum lake such as yellow No. 4, yellow No. 5, yellow No. 202, yellow No. 203, green No. 3 and blue No. 1; surface treatment organic pigments; anthraquinones such as astaxanthin and alizarin; Anthocyanidins, β-carotene, catenal, capsanthin, chalcone, calsamine, quercetin, crocin, chlorophyll, krk Natural pigments and dyes such as naphthoquinones such as chloroquine, cochineal, shikonin, bixin, flavones, betacyanidine, henna, hemoglobin, lycopene, riboflavin, rutin; p-phenylenediamine, toluene-2,5-diamine, o-, Oxidative dye intermediates and couplers such as m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcin, 1-naphthol, 2,6-diaminopyridine and their salts; indoline, etc. An auto-oxidizing dye of the following: dihydroxyacetone is preferred. *

In addition to these, cosmetic ingredient standards, cosmetic ingredient-specific formulation standards, Japan Cosmetic Industry Association ingredient name list, INCI dictionary (The International Cosmetic Ingredient Dictionary and Handbook), Quasi-drug ingredient standards, Japanese Pharmacopoeia, Pharmaceutical Additives Ingredients listed in standards, official food additives, etc., and Japanese and foreign patent publications and patent publications (including publications and republications) in which the international patent classification IPC belongs to the classification of A61K7 and A61K8 It is possible to contain known cosmetic ingredients, pharmaceutical ingredients, food ingredients, etc., such as listed ingredients, in known combinations, blending ratios and blending amounts.

Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Test 1) Adenosine triphosphate phosphatase expression inducing action The present inventor evaluated the adenosine triphosphate phosphatase expression inducing action using a quantitative PCR method.
"Test method and evaluation method"
Normal human epidermal keratinocytes (manufactured by Kurashiki Boseki Co., Ltd.) are cultured to sub-confluence, further cultured for 48 hours, and then added with the sample “invention product or control (comparative control)” for 6 hours and 12 hours. did. Extraction was performed from the cells at each time using an RNA extraction kit (QIAGEN), and cDNA was synthesized using the obtained RNA as a template and PrimeScript RT reagent Kit (Takara Bio). Using this cDNA, the expression levels of ATP2A2 gene and ATP2C1 gene were measured by quantitative PCR. ATP2A2 was evaluated using a sample collected 6 hours after the addition, and ATP2C1 was evaluated using a sample collected 12 hours after the addition. For quantitative PCR, SYBR Premix Ex Taq (Takara Bio Inc.) and Thermal Cycler Dice Real Time System (Takara Bio Inc.) were used. As an internal standard, the expression level of β-Actin gene, which is a housekeeping gene, was quantified, and the relative expression level with respect to β-Actin was calculated and used as the expression level of ATP2A2 gene and ATP2C1 gene. Qiagen ATP2A2, ATP2C1, and β-Actin were used as PCR primers.
"sample"
In addition, the sample used for the test by adding 20 μ of synephrine of the present invention (manufactured by Sigma Aldrich Japan GK). As a control (comparison control), a 70% 1,3-butylene glycol aqueous solution was prepared under the same conditions and used in the test.

(Test results)
The results are as shown in FIG. 1. Regarding the expression of ATP2A2, when the expression level in the control (comparative control) 70% 1,3-butylene glycol aqueous solution is 1.0, the expression level of synephrine is significantly increased to 1.85. It was confirmed that it has an effect of inducing the expression of ATP2A2.
The results are as shown in FIG. 2. Regarding the expression of ATP2C1, when the expression level in the 70% 1,3-butylene glycol aqueous solution of the control (comparative control) is 1.0, the expression level of synephrine is significantly increased to 1.62. It was confirmed that it has an effect of inducing the expression of ATP2C1.
Therefore, synephrine induces the expression of both ATP2A2 and ATP2C1, and is useful as an adenosine triphosphate phosphatase expression inducer.

(Prescription example) Manufacture of adenosine triphosphate phosphatase expression inducer and cosmetic composition According to the above evaluation results, the prescription examples are shown below. Each prescription example is manufactured by a conventional method in the production of each product. Only the blending amount was shown. The present invention is not limited to these.

(Formulation example 1) Adenosine triphosphate phosphatase expression inducer A gauze or liniment cloth is impregnated with a prescription solution in which appropriate amounts of synephrine, antibiotics, anti-inflammatory agents and the like are mixed, and attached to the wound. Alternatively, the synephrine-containing aqueous solution may be directly sprayed locally and covered with gauze or the like.

(Formulation Example 2) Milk Mass%
1.Squalane 5.0
2.Olive oil 5.0
3. Jojoba oil 5.0
4.Cetyl alcohol 1.5
5. Glycerin monostearate 2.0
6.Polyoxyethylene (20) cetyl ether 3.0
7. Polyoxyethylene (20) soorbitan monooleate 2.0
8.1,3-Butylene glycol 1.0
9.Glycerin 2.0
10.Synephrine of the present invention 0.3
11. Preservative (paraoxybenzoic acid ester) appropriate amount 12. Perfume appropriate amount 13. Residue with 100 purified water

(Formulation example 3) Moisturizing cream mass%
1.Squalane 10.0
2.liquid paraffin 10.0
3.Stearic acid 2.0
4.Dimethylpolysiloxane 1.0
5.Cholesterol 0.5
6. Vaseline 2.0
7.Dipropylene glycol 3.0
8.Glycerol monostearate2.0
9. Shirabirame collagen 1.0
10.Synephrine of the present invention 0.1
11. Preservative (Isopropylmethylphenol) Appropriate amount 12. Residue with 100 purified water

(Formulation example 4) Pack mass%
1.Polyvinyl alcohol 15.0
2.Carboxymethylcellulose sodium 5.0
3.Propylene glycol 3.0
4.Ethanol 10.0
5. Synephrine of the present invention 0.1
6. 鯛 Collagen 1.0
7. Antibacterial / preservative (polylysine) appropriate amount 8. Fragrance (rose water) appropriate amount 9. Residue with 100 purified water

(Formulation example 5) Essence liquid mass%
1.Polyvinyl alcohol 15.0
2.Hydroxyethyl cellulose 0.2
3.Carboxyvinyl polymer 0.2
4.Potassium hydroxide 0.025
5.1,3-Butylene glycol 5.0
6. Synephrine 1.0 of the present invention
7. Button rhizome or root bark 60% ethanol extract 1.0
8.Dipotassium glycyrrhizinate 0.2
9. Preservative (methyl paraoxybenzoate) appropriate amount 10. Perfume (rose water) appropriate amount 11. Residue to make 100 purified water

(Formulation Example 6) Cosmetic Oil Mass%
1.liquid paraffin 30.0
2.Squalane 20.0
3.Olive oil 20.0
4.Isopropyl palmitate 10.0
5. Hamasge Whole Herbal Hot Water Extract 3.0
6. Synephrine of the present invention 0.5
7. Dingji hot water extract 1.0
8. Grapefruit fruit or leaf hot water extract 3.0
9. Tochu Nakaba Hot Water Extract 3.0
10.Olive oil 1.0
11. Shea fat 1.0
12.Butylhydroxyanisole 0.1
13. Vitamin E derivative 0.1
14. Preservative (benzalkonium chloride) appropriate amount 15. Fragrance (rose water) appropriate amount 16. Residue as 100 purified water

(Formulation example 7) Facial cleansing cream mass%
1.Myristic acid 25.0
2.Stearic acid 5.0
3. Tallow fatty acid 5.0
4.Propylene glycol 10.0
5.Potassium hydroxide 6.0
6. Palm oil fatty acid diethanolamide 6.0
7. Synephrine of the present invention 0.5
8. Apple fruit 20% 1,3-butylene glycol extract 2.0
9.Kakkon hot water extract 2.0
10.Glycyrrhizic acid 1.0
11.Apricot kernel 0.1
12. Antiseptic (salicylic acid) 0.1
13. Perfume (home water) appropriate amount

(Formulation example 8) Body soap mass%
1.Potassium laurate 15.0
2.Potassium myristate 5.0
3.Propylene glycol 5.0
4. Synephrine of the present invention 0.5
5.Oolong tea leaves 70% 1,3-butylene glycol extract 1.0
6. Toki rhizome 70% 2,3-butylene glycol extract 0.5
7. Wakame 70% 1,3-butylene glycol extract 0.5
8. Melilot flower or leaf 70% 1,3-butylene glycol extract 0.5
9. Aloe pulp 70% ethanol extract 2.0
10 Monoammonium glycyrrhizinate 0.1
11. Preservative (Undecylenic acid, phenol) Appropriate amount 12. Fragrance (lavender water) Appropriate amount

(Prescription example 9) Sunscreen cosmetics (O / W type)
1.Oxybenzone 2.0
2.Octyl paramethoxycinnamate 5.0
3.Dihydroxymethoxybenzophenone 0.2
4.Squalane 10.0
5.Vaseline 5.0
6. Stearyl alcohol 3.0
7.Stearic acid 3.0
8. Glyceryl monostearate 2.0
9.Polyethyl acrylate 1.0
10.1,3-Butylene glycol 6.0
11. Edetate disodium 0.1
12.Triethanolamine 1.0
13.Titanium dioxide 5.0
14. Synephrine 2.0 of the present invention
15. Birch bark 70% dipropylene glycol extract 0.5
16. Cornflower leaf 50% propylene glycol extract 0.5
17. Kakkon 50% propylene glycol extract 0.5
18. Zushi fruit 50% dipropylene glycol extract 0.5
19. Preservative (benzyl paraoxybenzoate) appropriate amount 20. Fragrance (jasmine water) appropriate amount 21. Residue with 100 purified water

(Prescription Example 10) Shampoo Mass%
1.Lauryl sulfate triethanolamine 5.0
2. Sodium polyoxyethylene lauryl ether sulfate 12.0
3.1,3-Butylene glycol 4.0
4.Lauric acid diethanolamide 2.0
5. Edetate disodium 0.1
6. Synephrine 4.0 of the present invention
7. Clam bark hot water extract 2.0
8. Spike or rhizome 30% 1,4-butylene glycol extract 2.0
9. Toki 30% 1,4-butylene glycol extract 1.0
10.Hydroxypropyl chitosan solution 1.0
11. Mucopolysaccharide solution 1.0
12.Dipotassium glycyrrhizinate 0.1
13. Antibacterial and antiseptic (photosensitive element 101) Appropriate amount 14. pH adjuster Appropriate amount 15. Perfume (sandalwood water) Appropriate amount 16. Purified water

(Prescription Example 11) Rinse mass%
1. Stearyl trimethyl ammonium chloride 3.0
2.Cetostearyl alcohol 3.0
3.Polyoxyethylene lanolin ether 3.0
4.Propylene glycol 5.0
5.1,2-Pentanediol 2.0
6. Synephrine 3.0 of the present invention
7. Tokachinka flower 50% 1,3-butylene glycol extract 1.0
8. Forsythia leaf 50% 2,3-butylene glycol extract 2.0
9. Perfumed fruit 30% 1,2-butylene glycol extract 2.0
10. Yellow rhizome 50% 1,3-butylene glycol extract 1.0
11. Comfrey leaf or stem 50% 1,3-butylene glycol extract 1.0
12. Soybean seed natto fermentation liquid 0.5
13.Hydroxyethyl chitosan solution 0.5
14. Trehalose solution 0.5
15.Hydrolyzed silk solution 0.5
16. Antibacterial / preservative (benzalkonium chloride) appropriate amount 17. Fragrance (poisoned water) appropriate amount 18. Residue to make 100 purified water

(Prescription Example 12) Hair Liquid Mass%
1.Ethanol 29.0
2.Polyoxypropylene butyl ether phosphate 10.0
3.Polyoxypropylene monobutyl ether 5.0
4.Triethanolamine 1.0
5. Synephrine 1.0 of the present invention
6. Tormentilla root or rhizome 50% 1,3-butylene glycol extract 1.0
7. Hop female flower ear 50% ethanol extract 1.0
8. Melissa whole plant 50% ethanol extract 1.0
9. Usbasaicin rhizome 30% ethanol extract 1.0
10 Birch sap 1.0
11.Carpronium chloride 0.3
12. Hinokitiol 0.5
13.Keratin degradation solution 0.5
14. Stearyl glycyrrhetinate 0.1
15. Antibacterial and antiseptic (paraben, benzalkonium chloride) appropriate amount 16. Fragrance (rosehip water) appropriate amount 17. Residue to make 100 purified water

(Formulation example 13) Hair artnic mass%
1. l-Menthol 0.2
2.Ethanol 32.5
3.Polyoxyethylene hydrogenated castor oil 0.5
4.Propylene glycol 5.0
5.Diphenhydramine hydrochloride 0.3
6. Synephrine 2.0 of the present invention
7. Lavender flower or flower ear hot water extract 1.0
8. Belode oyster rhizome or root bark 50% ethanol extract 1.0
9. Ogon rhizome or root bark 50% ethanol extract 1.0
10. Persimmon rhizome or root bark 50% ethanol extract 1.0
11. Soybean seed hot water extract 1.0
12.Carboxymethylchitin solution 1.0
13.Cow crown extract solution 0.2
14. Vitamin E derivatives 0.2
15.Pantethine aqueous solution 0.2
16. Preservative (phenoxyethanol) Appropriate amount 17. Fragrance (Sage water) Appropriate amount

(Prescription Example 14) Hair growth / hair growth agent
1.Ethanol 60.0
2. Synephrine 1.5 of the present invention
3. Allergen 50% propylene glycol extract 2.0
4. Vitamin E derivative 0.5
5.Pepper tincture 0.5
6.Resorcin 0.5
7.Dipotassium glycyrrhizinate 0.5
8.Carboxymethylchitin solution 0.5
9. Collagen protein enzyme solution 2.0
10.Pig hematin solution 0.5
11. Porcine mucin solution 0.5
12. Amino acids (Arginine, Glycine, Glutamine, etc.) 0.5
13. Antibacterial and antiseptic (paraben) 0.1
14. Perfume (Rosemary water) Appropriate amount 15. Purified water 100

(Prescription Example 15) Hair loss inhibitor% by weight
1.Ethanol 40.0
2.Ethyl oleate 1.0
3.Polyoxyethylene (40) hydrogenated castor oil 2.0
4. Synephrine of the present invention 3.0
5. Sakura leaf 50% ethanol extract 2.0
6. Comfrey 60% ethanol extract 2.0
7.Glycyrrhizic acid 0.5
8. Preservative (ethyl paraoxybenzoate) appropriate amount 9. Perfume appropriate amount 10. Residue with 100 purified water

(Formulation Example 16) Granule bath agent
1.Sodium bicarbonate 60.0
2.Anhydrous sodium sulfate 30.0
3.borax 5.0
4. Synephrine 2.0 of the present invention
5. Eucalyptus hot water extract dry powder 1.0
6. Peach leaf 70% ethanol extract dry powder 1.0
7. Silk Protein Enzyme Decomposition Dry Powder 1.0
8. Pigment (Gungjo Green) appropriate amount

(Prescription Example 17) Mouth freshener
1.Ethanol 20.0
2.Glycerin 15.0
3. Polyoxyethylene hydrogenated castor oil 1.0
4.Saccharin 0.2
5.Chlorohexidine 0.01
6. Synephrine of the present invention 0.2
7.Green tea leaf hot water extract dry powder 0.1
8. Pigment (Gunjo green) appropriate amount 9. Residue with 100 purified water

The present invention finds an excellent adenosine triphosphate phosphatase expression inducing action on phenylethylamine derivatives or synephrine, and an adenosine triphosphate phosphatase expression inducer containing phenylethylamine derivatives or synephrine, and further, phenylethylamine derivatives or synephrines. A cosmetic composition having an adenosine triphosphate phosphatase expression-inducing action can be provided.

Claims

An adenosine triphosphate phosphatase expression inducer comprising a phenylethylamine derivative.
An adenosine triphosphate phosphatase expression inducer characterized by containing synephrine.
A cosmetic composition characterized by having an adenosine triphosphate phosphatase expression inducing action of a phenylethylamine derivative.
A cosmetic composition characterized by having an action of inducing expression of adenosine triphosphate phosphatase of synephrine.