CN109381362A - Shining life repair latex living of one kind and preparation method thereof - Google Patents
Shining life repair latex living of one kind and preparation method thereof Download PDFInfo
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- CN109381362A CN109381362A CN201811553266.3A CN201811553266A CN109381362A CN 109381362 A CN109381362 A CN 109381362A CN 201811553266 A CN201811553266 A CN 201811553266A CN 109381362 A CN109381362 A CN 109381362A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/41—Particular ingredients further characterized by their size
- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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Abstract
The shining life repair latex living of one kind, including following component in percentage by weight: the sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% ceramide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% 2-Hydroxyethyl methacrylate, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% ascorbyl palmitate.The gelling agent of 2-Hydroxyethyl methacrylate can deposit on the skin on waterproof, non-sticky, moisture absorption, flexible film, provide additional barrier frost effect, and allergic contact dermatitis will not be caused, apply the skin of the A1 group of repair latex water loss speed be significantly lower than without application lotion A2 group skin water loss speed.
Description
Technical field
This application involves a kind of skin care item, specifically, belong to a kind of repair latex.
Background technique
The barrier function of skin is obviously related to transepidermal water loss, various skin diseases such as dermatitis, psoriasis, ichthyosis
It is often damaged with stratum corneum barrier with serious xerosis and related through epidermis loss moisture increase, and ceramide is in skin screen
Hindering has special role in function.In addition, 2-Hydroxyethyl methacrylate can be in waterproof, non-sticky, moisture absorption, flexible film
Upper deposition on the skin, provides additional barrier frost effect, and will not cause allergic contact dermatitis, and methacrylic acid
2- hydroxyl ethyl ester gelling agent has repair.It is therefore desirable to research and develop a kind of skin repair lotion according to these characteristics.
Summary of the invention
The application in order to overcome at least one of the drawbacks of the prior art described above, provide a kind of shining living life repair latex and
Preparation method.
The application is intended to solve above-mentioned technical problem at least to a certain extent.
The primary and foremost purpose of the application is to solve technical problem: preparing a kind of shining life reparation living that can repair skin barrier
Lotion and preparation method thereof.
In order to solve the above technical problems, the technical solution of the application is as follows:
The shining life repair latex living of one kind, it is characterised in that: including following component in percentage by weight:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% mind
Through amide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% methacrylic acid 2- hydroxyl second
Ester, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% it is anti-bad
Hematic acid palmitate.
Further, further include 0.1% rose of Sharon extract, 0.2% Ginger P.E.
Further, further include 0.15% sesame oil, 0.15% saualane, 0.12% polypeptide,.
Further, further include 0.11% ketose, 0.17% titanium dioxide, 0.30% polypeptide ursolic acid.
Further, further include 0.40% oleanolic acid, the beautiful extracting solution of 0.10% promise, 0.10% false peptide.
A kind of preparation method of shining life repair latex living, comprising the following steps:
S1: dissolving cetanol and mix with blackcurrant oil, and then dissolves in ascorbyl palmitate and form solution one；
S2: other components are being formed into water phase formation solution one；
S3: solution one is mixed with solution two with dispersion machine, forms pre-emulsification product；
S4: pre-emulsification product is then forming nanometer oil water mixture with high-pressure homogenizer three circulations of homogenizing；
S5: nanometer oil water mixture is cooled to gel formed at room temperature agent.
Further, in step S1, be by cetanol and blackcurrant oil higher than 10 degree of cetanol melting point at a temperature of it is molten
It solves and mixes.
Further, in step S2, other components are formed into aqueous phase solution two under 85 degree.
It further, is that solution one is mixed 2 in the case where 9000 revolutions per minute with solution two with dispersion machine in step S3
Minute.
Further, in step S4, pre-emulsification product is then homogenized three with high-pressure homogenizer in 85 degree, 60,000 kPas and follows
Ring.
Compared with prior art, the beneficial effect of technical scheme is: the gelling agent of 2-Hydroxyethyl methacrylate
It can be deposited on waterproof, non-sticky, moisture absorption, flexible film and provide additional barrier frost effect on the skin, and will not
Cause allergic contact dermatitis, the water loss speed for applying the skin of the A1 group of repair latex is significantly lower than without application cream
The water loss speed of the skin of the A2 group of liquid, therefore it can be concluded that repair latex has actively work for repairing skin barrier
With.
Specific embodiment
It is described further below with reference to technical solution of the embodiment to the application.
Embodiment 1
The shining life repair latex living of one kind, including following component in percentage by weight:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% mind
Through amide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% methacrylic acid 2- hydroxyl second
Ester, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% it is anti-bad
Hematic acid palmitate.
By cetanol and blackcurrant oil higher than 10 degree of cetanol melting point at a temperature of dissolve and mix, and then dissolve in anti-
Bad hematic acid palmitate forms solution one, and other components are formed aqueous phase solution two under 85 degree, solution one and solution two are used
Dispersion machine mixes 2 minutes in the case where 9000 revolutions per minute, and above-mentioned pre-emulsification product is then equal with high pressure in 85 degree, 60,000 kPas
Change device and is homogenized three circulations.Above-mentioned nanometer oil water mixture is cooled to gel formed at room temperature agent.
Intercellular lipid, by ceramide, cholesterol and free fatty acid composition, the lifting in adjusting skin barrier stable state
It acts on.The qualitative and quantitative composition of barrier lipids is for maintaining effective skin barrier to be important.Skin barrier function with
Transepidermal water loss is obviously related.Ceramide generates good effect, the reparation cream of the application to the skin repair after damage
Contain ceramide ingredient in liquid.
In order to verify the moisturizing repair of repair latex, recruiting 12 female volunteers, (average age is 22 years old, the age
Range was at 21-23 years old), each volunteer chooses five test positions on volar forearm, wherein one group of (A group, 8) test department
With lauryl sodium sulfate continued stimulus 24 hours (by the way of patch stimulation), another set (B group, 4) did not had to then for position
Lauryl sodium sulfate stimulation is as control.A group is divided into A1 group and A2 group (each 4) again, and wherein A1 group is with dodecyl sulphur
Lotion is applied on the position of sour sodium stimulation, A2 group is then not processed after stimulation.To the measurement of test position respectively with 12
It is carried out before sodium alkyl sulfate stimulation, after being stimulated with lauryl sodium sulfate and at the 3rd, 8,15 day, in survey in the 3rd, 8,15 day
Amount is carried out after application lotion 12 hours.And measurement is carried out in the environment of 25 degree of temperature and 50% humidity.
It is measured first through transepidermal water loss value (being averaged), measurement result is shown in Table 1.
Table 1
As can be drawn from Table 1, in each period, the B group without lauryl sodium sulfate stimulation is lost through transepidermal water
Value Data difference is little, the water of A1, A2 group through transepidermal water loss Value Data and before being stimulated with lauryl sodium sulfate of B group
The difference for shunting mistake Value Data is also little.After lauryl sodium sulfate stimulates, from the data of A1, A2 group it can be concluded that,
Water loss speed be significantly greater than compare B group, and from the 3rd, 8,15 day data it can be concluded that, apply the A1 group of repair latex
Skin water loss speed be significantly lower than the A2 group without application lotion skin water loss speed, therefore can obtain
Repair latex has positive effect for repairing skin barrier out.
The gelling agent of 2-Hydroxyethyl methacrylate can be deposited on skin on waterproof, non-sticky, moisture absorption, flexible film
On skin, additional barrier frost effect is provided, and allergic contact dermatitis will not be caused, and 2-Hydroxyethyl methacrylate is solidifying
Jelly has repair.In order to verify the repair of 2-Hydroxyethyl methacrylate gelling agent, chooses 10 and suffer from dermatitis
Patient, each patient chooses the lotion that a dermatitis Zoned application is free of 2-Hydroxyethyl methacrylate gelling agent, and the is suffered from
Person chooses the lotion that another dermatitis Zoned application contains 2-Hydroxyethyl methacrylate gelling agent, by dermatologist according to red
Spot, roughness, furfur, serum knot and inflammatory conditions compare two dermatitis regions, can be apparent from application and contain metering system
The dermatitis region of the lotion of sour 2- hydroxyl ethyl ester gelling agent effect in terms of reducing erythema, coarse, furfur is be more good.
The lotion of the application is the product using nanostructure.Nanostructure can enhance the chemical stabilization of active material
Property, and be easy film forming on the skin and lock moisture.Increase be with the adhesiveness on surface super-fine material general aspects, adhesiveness with
The reduction of granularity and increase.This means that all nano particles usually obviously show the adhesiveness to surface.It is attached to skin
The nano particle of skin leads to the formation of film and subsequently results in black-out effect to prevent scattering and disappearing for moisture.Although some routines at
Point moisture can be preferably lockked such as vaseline, but what vaseline formed on the skin is very to occlude, and may be will affect
Skin is contacted to air.And use nanostructure product can be controlled occlusion skin surface, pass through increase amounts of particles
(under given particle size), reduction particle size increase obstruction and distribute to be controllably prevented moisture.Due to the water of reduction
It shunts and loses, occlusion causes skin hydration effect to increase.And it occludes skin also and can promote during active material penetrates to the skin.The application
Nanostructure mixed and form with blackcurrant oil by cetanol.The lotion of the application be the nanostructure suspension that will be concentrated with
Solution mixing containing other emulsion components.
Embodiment 2
The shining life repair latex living of one kind, preparation method is roughly the same with embodiment 1, including in percentage by weight
Following component:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% mind
Through amide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% methacrylic acid 2- hydroxyl second
Ester, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% rose of Sharon
Extract, 0.2% Ginger P.E.
Embodiment 3
The shining life repair latex living of one kind, preparation method is roughly the same with embodiment 1, including in percentage by weight
Following component:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% mind
Through amide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% methacrylic acid 2- hydroxyl second
Ester, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% it is anti-bad
Hematic acid palmitate, 0.1% rose of Sharon extract, 0.2% Ginger P.E, 0.15% sesame oil, 0.15% saualane,
0.12% polypeptide.
Embodiment 4
The shining life repair latex living of one kind, including following component in percentage by weight:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% mind
Through amide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% methacrylic acid 2- hydroxyl second
Ester, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% it is anti-bad
Hematic acid palmitate, 0.1% rose of Sharon extract, 0.2% Ginger P.E, 0.15% sesame oil, 0.15% saualane,
0.12% polypeptide, 0.11% ketose, 0.17% titanium dioxide, 0.30% polypeptide ursolic acid.
Embodiment 5
The shining life repair latex living of one kind, including following component in percentage by weight:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% mind
Through amide, 0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% methacrylic acid 2- hydroxyl second
Ester, 1% Ubiquinone-50,1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% it is anti-bad
Hematic acid palmitate, 0.1% rose of Sharon extract, 0.2% Ginger P.E, 0.15% sesame oil, 0.15% saualane,
0.12% polypeptide, 0.11% ketose, 0.17% titanium dioxide, 0.30% polypeptide ursolic acid, 0.40% olive
Acid, the beautiful extracting solution of 0.10% promise, 0.10% false peptide.
Obviously, above-described embodiment of the application is only intended to clearly illustrate the application example, and is not pair
The restriction of presently filed embodiment.For those of ordinary skill in the art, may be used also on the basis of the above description
To make other variations or changes in different ways.There is no necessity and possibility to exhaust all the enbodiments.It is all this
Made any modifications, equivalent replacements, and improvements etc., should be included in the claim of this application within the spirit and principle of application
Protection scope within.
Claims (10)
1. the shining life repair latex living of one kind, it is characterised in that: including following component in percentage by weight:
The sodium lauroyl lactylate of 1-5%, the carbomer of 0.3-1.6%, 0.50% tocopherol acetate, 0.1% ceramide,
0.5% phytosphingosine, 0.25% cholesterol, 0.25% linoleic acid, 1% 2-Hydroxyethyl methacrylate, 1% decene
Quinone, 1% cetanol, 1% blackcurrant oil, the alkyl phenol polyoxyethylene ether of 2-6%, 0.1% ascorbyl palmitate.
2. shining life repair latex living according to claim 1, it is characterised in that: it further include 0.1% rose of Sharon extract,
0.2% Ginger P.E.
3. shining life repair latex living according to claim 1 or 2, it is characterised in that: it further include 0.15% sesame oil,
0.15% saualane, 0.12% polypeptide.
4. shining life repair latex living according to claim 3, it is characterised in that: it further include 0.11% ketose, 0.17%
Titanium dioxide, 0.30% polypeptide ursolic acid.
5. shining life repair latex living according to claim 4, it is characterised in that: it further include 0.40% oleanolic acid,
The beautiful extracting solution of 0.10% promise, 0.10% false peptide.
6. a kind of preparation method of shining life repair latex living according to claim 1-5, it is characterised in that: packet
Include following steps:
S1: dissolving cetanol and mix with blackcurrant oil, and then dissolves in ascorbyl palmitate and form solution one;
S2: other components are formed into aqueous phase solution one；
S3: solution one is mixed with solution two with dispersion machine, forms pre-emulsification product;
S4: pre-emulsification product is then forming nanometer oil water mixture with high-pressure homogenizer three circulations of homogenizing；
S5: nanometer oil water mixture is cooled to gel formed at room temperature agent.
7. preparation method according to claim 6, it is characterised in that: be that cetanol and blackcurrant oil exist in step S1
It dissolves and mixes at a temperature of higher than 10 degree of cetanol melting point.
8. preparation method according to claim 6, it is characterised in that: in step S2, other components are formed under 85 degree
Aqueous phase solution two.
9. preparation method according to claim 6, it is characterised in that: be to use solution one and solution two to divide in step S3
Machine is dissipated to mix 2 minutes in the case where 9000 revolutions per minute.
10. preparation method according to claim 6, it is characterised in that: in step S4, pre-emulsification product is then in 85 degree, 6
Ten thousand kPas are homogenized three circulations with high-pressure homogenizer.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811553266.3A CN109381362A (en) | 2018-12-19 | 2018-12-19 | Shining life repair latex living of one kind and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811553266.3A CN109381362A (en) | 2018-12-19 | 2018-12-19 | Shining life repair latex living of one kind and preparation method thereof |
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| CN109381362A true CN109381362A (en) | 2019-02-26 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102037005A (en) * | 2008-05-22 | 2011-04-27 | 国家科学研究中心 | New optically pure compounds for improved therapeutic efficiency |
| CN104940058A (en) * | 2015-06-02 | 2015-09-30 | 丽江永胜边屯食尚养生园有限公司 | Essence composition and preparation method thereof |
| JP2016222612A (en) * | 2015-06-01 | 2016-12-28 | 昭和電工株式会社 | Cosmetic and skin external preparation |
-
2018
- 2018-12-19 CN CN201811553266.3A patent/CN109381362A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102037005A (en) * | 2008-05-22 | 2011-04-27 | 国家科学研究中心 | New optically pure compounds for improved therapeutic efficiency |
| JP2016222612A (en) * | 2015-06-01 | 2016-12-28 | 昭和電工株式会社 | Cosmetic and skin external preparation |
| CN104940058A (en) * | 2015-06-02 | 2015-09-30 | 丽江永胜边屯食尚养生园有限公司 | Essence composition and preparation method thereof |
Non-Patent Citations (5)
| Title |
|---|
| 区英鸿 等: "《塑料手册》", 28 February 1991, 兵器工业出版社 * |
| 张晓梅: "《脱敏护肤》", 31 January 2006, 辽宁科学技术出版社 * |
| 朱南平 等: "《实物临床药物手册》", 31 January 2009, 上海世界图书出版公司 * |
| 薛巍 等: "《生物医用水凝胶》", 31 December 2012, 暨南大学出版社 * |
| 裘炳毅 等: "《现代化妆品科学与技术》", 31 March 2016, 中国轻工业出版社 * |
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Application publication date: 20190226 |