CN115040427A - Hand sanitizer with slow release effect and preparation method thereof - Google Patents
Hand sanitizer with slow release effect and preparation method thereof Download PDFInfo
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- CN115040427A CN115040427A CN202210633888.7A CN202210633888A CN115040427A CN 115040427 A CN115040427 A CN 115040427A CN 202210633888 A CN202210633888 A CN 202210633888A CN 115040427 A CN115040427 A CN 115040427A
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- Prior art keywords
- polyvinyl alcohol
- amino acid
- hand sanitizer
- release effect
- colloidal particles
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- 230000000694 effects Effects 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims description 9
- 239000004372 Polyvinyl alcohol Substances 0.000 claims abstract description 73
- 229920002451 polyvinyl alcohol Polymers 0.000 claims abstract description 73
- 235000001014 amino acid Nutrition 0.000 claims abstract description 70
- 229940024606 amino acid Drugs 0.000 claims abstract description 70
- 150000001413 amino acids Chemical class 0.000 claims abstract description 70
- 239000002245 particle Substances 0.000 claims abstract description 45
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 14
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims abstract description 8
- 239000004471 Glycine Substances 0.000 claims abstract description 4
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims abstract description 4
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims abstract description 4
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims abstract description 4
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims abstract description 4
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000004279 alanine Nutrition 0.000 claims abstract description 4
- 235000003704 aspartic acid Nutrition 0.000 claims abstract description 4
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000014705 isoleucine Nutrition 0.000 claims abstract description 4
- 229960000310 isoleucine Drugs 0.000 claims abstract description 4
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims abstract description 4
- 235000013930 proline Nutrition 0.000 claims abstract description 4
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 15
- 239000000203 mixture Substances 0.000 claims description 14
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 9
- 238000003756 stirring Methods 0.000 claims description 9
- 238000013268 sustained release Methods 0.000 claims description 9
- 239000012730 sustained-release form Substances 0.000 claims description 9
- 239000006185 dispersion Substances 0.000 claims description 8
- 229920000058 polyacrylate Polymers 0.000 claims description 8
- 239000007788 liquid Substances 0.000 claims description 7
- 238000000034 method Methods 0.000 claims description 7
- 235000006408 oxalic acid Nutrition 0.000 claims description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 6
- 239000003054 catalyst Substances 0.000 claims description 6
- 239000000693 micelle Substances 0.000 claims description 6
- 238000000889 atomisation Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000012046 mixed solvent Substances 0.000 claims description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 125000004400 (C1-C12) alkyl group Chemical group 0.000 claims description 2
- 239000000686 essence Substances 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 241001529742 Rosmarinus Species 0.000 abstract description 12
- 239000000126 substance Substances 0.000 abstract description 10
- 230000009471 action Effects 0.000 abstract description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 abstract 1
- 229940073507 cocamidopropyl betaine Drugs 0.000 abstract 1
- 229940057950 sodium laureth sulfate Drugs 0.000 abstract 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 abstract 1
- LOBXNKKFDKXXQW-UHFFFAOYSA-M sodium;3-[dodecanoyl(methyl)amino]propanoate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCC([O-])=O LOBXNKKFDKXXQW-UHFFFAOYSA-M 0.000 abstract 1
- 230000000052 comparative effect Effects 0.000 description 17
- 239000000047 product Substances 0.000 description 12
- 238000005406 washing Methods 0.000 description 8
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- 238000004140 cleaning Methods 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 3
- 230000003078 antioxidant effect Effects 0.000 description 3
- 230000006866 deterioration Effects 0.000 description 3
- 239000012466 permeate Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 238000004132 cross linking Methods 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- 229910021645 metal ion Inorganic materials 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
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- DOUMFZQKYFQNTF-WUTVXBCWSA-N (R)-rosmarinic acid Chemical compound C([C@H](C(=O)O)OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C1=CC=C(O)C(O)=C1 DOUMFZQKYFQNTF-WUTVXBCWSA-N 0.000 description 1
- QRYRORQUOLYVBU-VBKZILBWSA-N Carnosic acid Natural products CC([C@@H]1CC2)(C)CCC[C@]1(C(O)=O)C1=C2C=C(C(C)C)C(O)=C1O QRYRORQUOLYVBU-VBKZILBWSA-N 0.000 description 1
- XUSYGBPHQBWGAD-PJSUUKDQSA-N Carnosol Chemical compound CC([C@@H]1C2)(C)CCC[C@@]11C(=O)O[C@@H]2C2=C1C(O)=C(O)C(C(C)C)=C2 XUSYGBPHQBWGAD-PJSUUKDQSA-N 0.000 description 1
- MMFRMKXYTWBMOM-UHFFFAOYSA-N Carnosol Natural products CCc1cc2C3CC4C(C)(C)CCCC4(C(=O)O3)c2c(O)c1O MMFRMKXYTWBMOM-UHFFFAOYSA-N 0.000 description 1
- ZNZYKNKBJPZETN-WELNAUFTSA-N Dialdehyde 11678 Chemical compound N1C2=CC=CC=C2C2=C1[C@H](C[C@H](/C(=C/O)C(=O)OC)[C@@H](C=C)C=O)NCC2 ZNZYKNKBJPZETN-WELNAUFTSA-N 0.000 description 1
- CEEMRWKKNNEQDT-UHFFFAOYSA-N Rosmanol Natural products CC(C)c1cc2C(OC(=O)C)C3OC(=O)C4(CCCC(C)(C)C34)c2c(OC(=O)C)c1OC(=O)C CEEMRWKKNNEQDT-UHFFFAOYSA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
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- 230000002708 enhancing effect Effects 0.000 description 1
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- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 210000004324 lymphatic system Anatomy 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 231100000956 nontoxicity Toxicity 0.000 description 1
- 230000001151 other effect Effects 0.000 description 1
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- 238000007254 oxidation reaction Methods 0.000 description 1
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- 229920000205 poly(isobutyl methacrylate) Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 229940092258 rosemary extract Drugs 0.000 description 1
- 235000020748 rosemary extract Nutrition 0.000 description 1
- LCAZOMIGFDQMNC-FORWCCJISA-N rosmanol Chemical compound C1CCC(C)(C)[C@@H]2[C@H]3[C@@H](O)C(C=C(C(=C4O)O)C(C)C)=C4[C@]21C(=O)O3 LCAZOMIGFDQMNC-FORWCCJISA-N 0.000 description 1
- 239000001233 rosmarinus officinalis l. extract Substances 0.000 description 1
- 230000037307 sensitive skin Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000036559 skin health Effects 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000012798 spherical particle Substances 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8129—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal or ketal radical; Compositions of hydrolysed polymers or esters of unsaturated alcohols with saturated carboxylic acids; Compositions of derivatives of such polymers, e.g. polyvinylmethylether
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
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- C08J3/24—Crosslinking, e.g. vulcanising, of macromolecules
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- C08J2329/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by an alcohol, ether, aldehydo, ketonic, acetal, or ketal radical; Hydrolysed polymers of esters of unsaturated alcohols with saturated carboxylic acids; Derivatives of such polymer
- C08J2329/02—Homopolymers or copolymers of unsaturated alcohols
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- C08J2433/00—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers
- C08J2433/04—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters
- C08J2433/06—Characterised by the use of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides, or nitriles thereof; Derivatives of such polymers esters of esters containing only carbon, hydrogen, and oxygen, the oxygen atom being present only as part of the carboxyl radical
- C08J2433/10—Homopolymers or copolymers of methacrylic acid esters
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Abstract
The invention relates to a hand sanitizer with a slow release effect, which comprises the following components in parts by mass: 5-7 parts of polyvinyl alcohol colloidal particles containing amino acid, 2-4 parts of rosemary, 20-25 parts of sodium lauroyl methyl aminopropionate, 10-13 parts of cocamidopropyl betaine, 4-6 parts of sodium laureth sulfate, an auxiliary agent and water; the amino acid is selected from one or more of glycine, alanine, isoleucine, proline and aspartic acid. The cross-linked polyvinyl alcohol colloidal particles are wrapped with various amino acids, and can be isolated from other components in the hand sanitizer, so that when the product is idle, the amino acids and the rosemary are ensured to exist independently, and the amino acids and the rosemary do not influence each other; when the product is used, the polyvinyl alcohol colloidal particles gradually deform or break along with the mechanical force action of the palm of a user, so that the experience of consumers can be increased, and the amino acid functional substances in the polyvinyl alcohol colloidal particles can be released instantly, so that the effect of moistening the skin is achieved when the product is used.
Description
Technical Field
The invention belongs to the field of personal cleaning, and particularly relates to a hand sanitizer with a slow release effect and a preparation method thereof.
Background
Rosemary is originally produced from Mediterranean sea, and has excellent antioxidant, refreshing, sterilizing and other effects. Rosemary has strong oxidation resistance, is a natural substance, and has good safety. The antioxidant mechanism is caused by the effects of the components of rosmanol, carnosol and rosemary dialdehyde in the rosemary extract. Compared to other artificially prepared antioxidants, rosemary is a favored target for daily chemical manufacturers due to its strong antioxidant properties (reported to be about 5 times as potent as BHT and BHA), natural non-toxicity, and wide source.
The amino acid component is another material preferred by daily chemical manufacturers. Amino acids also have an important effect on human skin: the amino acid can enhance skin immunity, regulate water content and pH value of skin, and balance surface oil. The amino acid can improve the anti-allergy capability of sensitive skin, and can generate a chelation reaction with divalent metal ions in the skin to prevent excessive divalent metal ions from generating a crosslinking effect with collagen in the skin, so that enough collagen fibers and elastic fibers are maintained, the skin is kept smooth, fine and elastic, and wrinkles are prevented from being generated. Amino acids also have the function of enhancing the lymphatic system, which can improve the skin's anti-allergic ability and metabolize aging cells in the body, so amino acids are essential substances for skin health.
For the above reasons, daily chemical manufacturers wish to apply the above two natural ingredients to personal care products, such as hand washing lotion and facial cleanser, in order to provide functional effects to the products while having no irritation to the digestive tract, respiratory tract and skin. However, amino acid and rosemary are natural organic matters, and the amino acid and the rosemary coexist in the formula for a long time, so that unstable phenomena such as product layering and too fast deterioration are easily caused, and the functionality is greatly reduced. Therefore, daily chemical manufacturers hope that in daily chemical products, rosemary and amino acid can exist relatively independently when the products are idle; when in use, the two can exert the effect at the same time.
Therefore, a technical solution is needed to solve the above-mentioned problems.
Disclosure of Invention
The invention discloses a hand sanitizer, which contains cross-linked polyvinyl alcohol colloidal particles, wherein various amino acids are wrapped in the colloidal particles and can be isolated from other components in the hand sanitizer, so that when a product is idle, the amino acids and rosemary are ensured to exist independently, and are not influenced by each other; when the product is used, the polyvinyl alcohol colloidal particles gradually deform or break along with the mechanical force of the palm of a user, so that the amino acid functional substances in the polyvinyl alcohol colloidal particles are released instantly, and the effect of moistening the skin is achieved when the product is used.
The invention aims to provide a hand sanitizer with a slow release effect, which is realized by the following technical means.
A hand sanitizer with a slow release effect comprises the following components in parts by mass:
auxiliary agent
Water;
the amino acid is selected from one or more of glycine, alanine, isoleucine, proline and aspartic acid.
The specific structure of the polyvinyl alcohol colloidal particle containing amino acid is a solid structure in which the amino acid is uniformly wrapped in spherical particles made of polyvinyl alcohol.
The surfactants are low-irritation surfactants, and have excellent suspending and solubilizing effects on rosemary and polyvinyl alcohol colloidal particles containing amino acid.
Further, the auxiliary agent is selected from one or more of propylene glycol, sodium chloride, essence and citric acid.
Further, the pH value of the hand sanitizer with the slow release effect is 6.5-7.0.
The invention also aims to provide a preparation method of the hand sanitizer with the slow release effect, which comprises the following steps:
preparation of polyvinyl alcohol colloidal particles containing amino acid:
s1, heating and stirring polyvinyl alcohol and oxalic acid under a catalyst system to obtain cross-linked polyvinyl alcohol;
s2, placing the crosslinked polyvinyl alcohol in a mixed solvent of water and glycerol, and stirring to obtain a crosslinked polyvinyl alcohol mixture;
s3, mixing the crosslinked polyvinyl alcohol mixture with the amino acid, adding a polyacrylate derivative, and stirring to obtain a dispersion liquid;
and S4, carrying out high-pressure atomization drying on the dispersion liquid to obtain the amino acid-containing polyvinyl alcohol colloidal particles.
In the above step S1, the catalyst is usually selected from strong acids, such as concentrated sulfuric acid, etc., and a part of the hydroxyl groups on the polyvinyl alcohol reacts with oxalic acid to form crosslinked polyvinyl alcohol. The obtained crosslinked polyvinyl alcohol can be primarily purified by means of catalyst removal, washing and the like. The obtained cross-linked polyvinyl alcohol has a complex structure, contains partial unreacted hydroxyl, and is easy to form intermolecular hydrogen bonds with groups in amino acid, so that the intermolecular force between the polyvinyl alcohol and the amino acid is enhanced; and the group reacting with oxalic acid forms a bridge bond to form a connection point of the network structure. The complex reticular structure is connected with different polyvinyl alcohol molecular chains, and has good film forming property and wrapping property.
The above-mentioned steps S2-S3 are physical blending steps, and the main purpose is to mix the crosslinked polyvinyl alcohol with the amino acid so that the amino acid is uniformly dispersed in the system. The polyacrylate derivative is added to facilitate the dispersion of the amino acid.
The above-mentioned step S4 is intended for granulation, and may be carried out by using an atomizing gun. By controlling the pressure and the caliber of the atomizing gun, the particle size of the formed polyvinyl alcohol colloidal particle containing amino acid can reach the optimal level, and the influence of over-coarse or over-fine on the use experience is avoided.
Further, the polyvinyl alcohol: oxalic acid: the mass ratio of the mixed solvent is 50 (3-5) to (200-250).
Furthermore, the mass ratio of the polyvinyl alcohol colloidal particles containing the amino acid to the amino acid is 100 (5-10).
Further, the polyacrylate derivative has the following structure:
wherein R and R' are independently selected from C1-C12 alkyl structures.
The acrylate derivative has a structure containing a branched chain and a longer branched chain, and has a better effect on the dispersion of amino acid. This is probably due to the deeper winding of both R and R' with amino acids; linear polyacrylate derivatives may not have the above characteristics.
Further, the amount of the polyacrylate derivative added is 0.5 to 1 wt% of the crosslinked polyvinyl alcohol mixture.
Further, the particle size of the amino acid-containing polyvinyl alcohol colloidal particles is 50-70 μm.
The invention has the following beneficial effects:
1. the hand sanitizer with the slow release effect, which is obtained by the technical scheme of the invention, contains cross-linked polyvinyl alcohol colloidal particles, and various amino acids are wrapped in the colloidal particles and can be isolated from other components in the hand sanitizer, so that when a product is idle, the amino acids and rosemary can be ensured to exist independently, and the amino acids and the rosemary do not influence each other; when the product is used, the polyvinyl alcohol colloidal particles gradually deform or break along with the mechanical force action of the palm of a user, so that the consumer experience can be increased, and the amino acid functional substances in the polyvinyl alcohol colloidal particles can be released instantly, so that the effect of moistening the skin is exerted when the product is used.
2. The cross-linked polyvinyl alcohol colloidal particles in the technical scheme of the invention have a relatively complex structure, and on one hand, sufficient hydrogen bonds can be provided, so that the cross-linked polyvinyl alcohol colloidal particles can be more tightly combined with other substances, such as amino acid or glycerol; on the other hand, the gel has a large number of bridge bonds, a formed reticular structure is very large, the film forming property and the wrapping property are good, water in the formula is not easy to permeate into the colloidal particles, and the colloidal particles are not easy to swell.
Drawings
FIG. 1 shows the appearance of examples 1 to 3 and comparative examples 1 to 2 in both of sample A and sample B.
Detailed Description
In order to more clearly illustrate the technical solution of the present invention, the following examples and comparative examples are listed. The starting materials, reactions and work-up procedures presented in the examples and comparative examples are, unless otherwise stated, those commonly available on the market and well known to those skilled in the art.
In the high-pressure atomization drying adopted in the embodiment of the invention, the pressure of an atomization gun is about 1.3-1.4MPa, the diameter of the gun opening is about 1mm, the drying temperature is controlled at 60-70 ℃, and the average particle size of the cross-linked polyvinyl alcohol-containing colloidal particles obtained by the parameters is about 50-65 μm.
Examples
The components and the corresponding parts by mass of the hand sanitizer with sustained release effect in examples 1-3 are shown in table 1.
Table 1 examples 1-3 components and parts by weight of a hand sanitizer with sustained release
The preparation method of the polyvinyl alcohol colloidal particles containing the amino acid comprises the following steps:
s1, heating polyvinyl alcohol and oxalic acid (50:3, m/m) to 90 ℃ in a catalyst concentrated sulfuric acid (0.3 wt% of polyvinyl alcohol) system, stirring, removing water in the system to enable forward reaction to be complete as far as possible, then concentrating a solvent under reduced pressure, and passing through a column to elute catalyst residues to obtain crosslinked polyvinyl alcohol;
s2, placing the crosslinked polyvinyl alcohol into a mixed solvent of water and glycerol, and stirring (the ratio of the crosslinked polyvinyl alcohol to the water to the glycerol is 50:100:100) to obtain a crosslinked polyvinyl alcohol mixture;
s3, mixing the crosslinked polyvinyl alcohol mixture with the amino acids according to the calculated mass ratio, adding 0.5 wt% of polyisobutyl methacrylate (purchased from technical health chemical Co., Ltd.) of the crosslinked polyvinyl alcohol mixture, and uniformly stirring to obtain a dispersion liquid;
s4, carrying out high-pressure atomization drying on the dispersion liquid to obtain the amino acid-containing polyvinyl alcohol colloidal particles, wherein the specific ratio of each obtained amino acid in the amino acid-containing polyvinyl alcohol colloidal particles is finally measured, and is shown in Table 2.
TABLE 2 respective amino acid contents of amino acid-containing polyvinyl alcohol micelles in Table 1
After polyvinyl alcohol colloidal particles containing amino acid are prepared, all the components are sequentially added into a reaction kettle according to the mass parts in the table 1, the mixture is stirred for 30min at the temperature of 30 ℃, then the pH value is adjusted by citric acid, and the mixture is discharged from the bottom of the kettle to obtain the liquid soap products of examples 1-3.
Comparative example
Comparative examples 1-2 were set up based on example 1. The components and the corresponding parts by mass of the hand sanitizer of comparative examples 1-2 are shown in table 3.
Table 3 components and parts by mass of the hand washing solutions of example 1 and comparative examples 1 to 2
Wherein,
in comparative example 1:
the raw materials, the quality of the raw materials and the related preparation method of the amino acid-containing polyvinyl alcohol micelle (reference) are the same as those of the example 1, and only oxalic acid in the example 1 is replaced by acetic acid with equal quality, namely, the polyvinyl alcohol and the acetic acid are subjected to esterification reaction. The resulting polyvinyl alcohol is not the crosslinked polyvinyl alcohol described in example 1, and is more likely to be a linear structure.
The final measured specific ratios of the individual amino acids in the amino acid-containing polyvinyl alcohol micelles (reference) are also shown in table 2.
In comparative example 2:
various amino acids are directly added, and the total amount is 0.31 part; the mass ratio of glycine, alanine, isoleucine, proline and aspartic acid is 1.0:1.4:1.3:1.5: 1.0.
Test example
The hand washing solutions obtained in examples 1 to 3 and comparative examples 1 to 2 were subjected to stability tests. The specific method comprises the following steps: 200mL of each of the hand sanitizers of examples 1 to 3 and comparative examples 1 to 2 was put in a PE transparent bottle and sealed to prepare sample A. The same sample was then placed in a high temperature oven at 45 ℃ for 2 weeks to serve as sample B.
The experimenter was called 20 volunteers at the test center, and the samples were subjected to appearance observation and tried for two weeks. The record summarizes the sample appearance, as well as the trial experience. The resulting structures are shown in tables 4 and 5.
Wherein, the mode of trying the sample is as follows: the volunteers use the samples to wash hands in the morning, at noon and evening, about 1g of the samples are taken and placed in the hands, the hand centers are gently rubbed for 10S, and then the uniformly rubbed samples are coated on the two hands, so that the mechanical force of palm rubbing is utilized to break the colloidal particles and release amino acid.
TABLE 4 appearance of hand sanitizers obtained in examples 1-3 and comparative examples 1-2
While the appearance of the cleaning compositions of both sample a and sample B is shown in fig. 1, it can also be seen that the cleaning compositions of comparative examples 1-2 show a more pronounced change in appearance after storage for extended periods in a high temperature environment, whereas the cleaning compositions of examples 1-3 do not show such a change.
Table 5 experience on hand sanitizer testing obtained in example 1 and comparative examples 1-2
As can be seen from table 5, the samples a and B in example 1 have consistent user experience evaluation after undergoing the stability test in high temperature environment, which is caused by the good sustained release effect of the cross-linked polyvinyl alcohol micelle on the amino acid itself. When the modified polyvinyl alcohol gel is idle, the polyvinyl alcohol with the cross-linked structure provides a tough shell for the amino acid wrapped by the modified polyvinyl alcohol, and other components in the formula are difficult to permeate into colloidal particles even in a high-temperature water-rich environment, so that the performance of the amino acid cannot be negatively influenced, and the performance of the amino acid can be maintained for a long time. When the hand-washing powder is used, after the hand-washing powder is kneaded by the mechanical force of the palm of a volunteer, the cross-linked polyvinyl alcohol colloidal particles are broken, and the wrapped amino acid can be instantly released to the palm skin to play a role in cooperation with other components in the formula.
The sample B of comparative examples 1-2, however, showed significant changes in its physicochemical properties after being left at high temperatures for a long period of time: in comparative example 1, the polyvinyl alcohol colloidal particles have a lower degree of crosslinking, more linear structures than linear structures, but not body-type structures, so that the swelling phenomenon is generated when the polyvinyl alcohol colloidal particles are in a high-temperature water-rich environment for a long time, namely, the sizes of the polyvinyl alcohol colloidal particles become uneven and the texture becomes soft after a large amount of water in a formula is absorbed into the colloidal particles because the structure of the polyvinyl alcohol colloidal particles is too loose and the water easily permeates into the colloidal particles, so that a volunteer hardly experiences the pleasant feeling of breakage of the colloidal particles in hands; and along with the occurrence of the swelling phenomenon, a large amount of amino acid is also released into the formula, so that the deterioration is more easily caused, and the efficacy and performance of the amino acid are weakened in the hand washing process of volunteers. In the comparative example 2, the amino acid is directly contacted with all the components in the formula because no colloidal particles exist, so that the deterioration is easily caused in a high-temperature and water-rich environment, the appearance of the hand sanitizer is changed, and the efficacy performance of the amino acid is greatly weakened in the hand washing process of a volunteer.
It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.
Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.
Claims (9)
1. The hand sanitizer with the slow release effect is characterized by comprising the following components in parts by mass:
the amino acid is selected from one or more of glycine, alanine, isoleucine, proline and aspartic acid.
2. The hand sanitizer with slow release effect according to claim 1, wherein the auxiliary agent is selected from one or more of propylene glycol, sodium chloride, essence and citric acid.
3. The hand sanitizer with slow release effect according to claim 1, wherein the pH of the hand sanitizer with slow release effect is 6.5-7.0.
4. A method of preparing a hand sanitizer with sustained release as claimed in any of claims 1 to 3, wherein the method of preparing a hand sanitizer with sustained release comprises the steps of:
preparation of polyvinyl alcohol colloidal particles containing amino acid:
s1, heating and stirring polyvinyl alcohol and oxalic acid under a catalyst system to obtain cross-linked polyvinyl alcohol;
s2, placing the crosslinked polyvinyl alcohol in a mixed solvent of water and glycerol, and stirring to obtain a crosslinked polyvinyl alcohol mixture;
s3, mixing the crosslinked polyvinyl alcohol mixture with the amino acid, adding a polyacrylate derivative, and stirring to obtain a dispersion liquid;
and S4, carrying out high-pressure atomization drying on the dispersion liquid to obtain the amino acid-containing polyvinyl alcohol colloidal particles.
5. The method for preparing a hand sanitizer with sustained release effect according to claim 4, wherein the polyvinyl alcohol: oxalic acid: the mass ratio of the mixed solvent is 50 (3-5) to (200-250).
6. The preparation method of the hand sanitizer with the slow release effect according to claim 4, wherein the mass ratio of the amino acid-containing polyvinyl alcohol micelle to the amino acid is 100 (5-10).
7. The method for preparing a hand sanitizer with sustained release effect according to claim 4, wherein the polyacrylate derivative has the following structure:
wherein R and R' are independently selected from C1-C12 alkyl structures.
8. The method for preparing a hand sanitizer with sustained release effect according to claim 4, wherein the polyacrylate derivative is added in an amount of 0.5 to 1 wt% of the crosslinked polyvinyl alcohol mixture.
9. The method for preparing a hand sanitizer with sustained release effect according to claim 4, wherein the particle size of the amino acid-containing polyvinyl alcohol micelle is 50 to 70 μm.
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| JP2016222612A (en) * | 2015-06-01 | 2016-12-28 | 昭和電工株式会社 | Cosmetic and skin external preparation |
| CN108125857A (en) * | 2018-01-10 | 2018-06-08 | 威莱(广州)日用品有限公司 | A kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof |
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