JPH06239733A - Facial cleansing agent - Google Patents

Facial cleansing agent

Info

Publication number
JPH06239733A
JPH06239733A JP5157493A JP5157493A JPH06239733A JP H06239733 A JPH06239733 A JP H06239733A JP 5157493 A JP5157493 A JP 5157493A JP 5157493 A JP5157493 A JP 5157493A JP H06239733 A JPH06239733 A JP H06239733A
Authority
JP
Japan
Prior art keywords
enzyme
capsule
gelatin capsule
encapsulated
gelatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP5157493A
Other languages
Japanese (ja)
Inventor
Katsuhiko Yoshida
勝彦 吉田
Masakatsu Ota
昌勝 大田
Takanori Kashiwagi
尊紀 柏木
Takashi Kondo
隆 近藤
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kanebo Ltd
Fuji Capsule Co Ltd
Original Assignee
Kanebo Ltd
Fuji Capsule Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kanebo Ltd, Fuji Capsule Co Ltd filed Critical Kanebo Ltd
Priority to JP5157493A priority Critical patent/JPH06239733A/en
Publication of JPH06239733A publication Critical patent/JPH06239733A/en
Pending legal-status Critical Current

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Abstract

PURPOSE:To obtain an enzyme-included gelatin capsule-containing facial cleansing agent excellent in storage stability and capable of enhancing cleansing effect by functioning the capsule as a soft scrubbing agent and simultaneously disintegrating the capsule and releasing the included enzyme. CONSTITUTION:This facial cleansing agent is characterized by containing an enzyme-included gelatin capsule having 0.1-3.0mm particle diameter as a scrubbing agent obtained by insolublizing a gelatin capsule, obtained by blending 30-79.9 pts.wt. one or more substances among liquid paraffin, squalane and silicone with 0.1-10 pts.wt. enzyme or immobilized enzyme selected from protease, lipase and muramidase, with acetaldehyde and/or propionic aldehyde of 0.1-3wt.% based on the capsule weight.

Description

【発明の詳細な説明】Detailed Description of the Invention

【0001】[0001]

【産業上の利用分野】本発明は、改良された酵素内包ゼ
ラチンカプセルをスクラブ剤として配合する洗顔料に関
する。
FIELD OF THE INVENTION The present invention relates to a face wash containing an improved enzyme-encapsulated gelatin capsule as a scrubbing agent.

【0002】[0002]

【従来の技術及び発明が解決しようとする課題】洗顔料
には洗顔時の汚れ除去効率及びマッサージ効果を高める
目的でスクラブ剤が配合されている。従来のスクラブ剤
はポリエチレンビーズ、結晶性セルロース、クルミ殻粒
及びおがくず等の硬スクラブと寒天、ポリアクリル酸塩
及びアルギン酸塩等の軟スクラブの二種類に大別され
る。
2. Description of the Related Art A scrubbing agent is incorporated in a face wash for the purpose of enhancing the efficiency of removing stains on the face and the massage effect. Conventional scrubbing agents are roughly classified into two types: hard scrubs such as polyethylene beads, crystalline cellulose, walnut shells and sawdust, and soft scrubs such as agar and polyacrylates and alginates.

【0003】しかし、従来の硬スクラブは使用時に刺激
を感じたり異物感を伴うものが多く安全性上問題となっ
ていた。一方、軟スクラブは製剤中で膨潤し系に悪影響
を及ぼすものや使用時に顕著な効果を感じられないもの
が多い。そのため、適度な硬さを有し製剤中で安定なス
クラブ剤が求められていた。
However, the conventional hard scrubs often cause irritation or foreign matter during use, which has been a safety problem. On the other hand, soft scrub often swells in the formulation and adversely affects the system, or does not have a noticeable effect during use. Therefore, a scrub agent having an appropriate hardness and stable in the preparation has been demanded.

【0004】また、スクラブ剤は洗浄及びマッサージ効
果を高める目的で製剤中に配合されているものであり、
物理的効果に加え更なる機能付与が求められていた。
The scrub agent is incorporated in the preparation for the purpose of enhancing the cleaning and massage effects,
In addition to physical effects, it was required to add further functions.

【0005】一方、洗顔料には洗浄効果を目的として、
酵素の配合が試みられており、家庭用洗濯洗剤を模倣し
た、粉末洗顔料に酵素を配合した商品が上市されてい
る。しかし、酵素は水が共存する、クリーミーソープ、
クレンジングクリーム、マッサージクリーム、クレンジ
ンクローション及びクレンジングジェル等の製剤にその
まま配合すると、効果が著しく低下あるいは消失する。
On the other hand, a facial cleanser is used for the purpose of cleaning.
Attempts have been made to mix enzymes, and products that mix enzymes with powder facial cleansers, which imitate household laundry detergents, are on the market. However, as for the enzyme, creamy soap, in which water coexists,
If it is directly added to a preparation such as cleansing cream, massage cream, cleansing lotion or cleansing gel, the effect will be significantly reduced or disappeared.

【0006】これらの問題点を解決するために、酵素を
化学修飾、固定化或いはカプセル化することが試みられ
てきた。しかし、化学修飾及び固定化された酵素は安全
性面や適用される製剤が制限され、またカプセル化酵素
は製剤中でカプセルが膨潤崩壊する等の問題点があっ
た。
In order to solve these problems, it has been attempted to chemically modify, immobilize or encapsulate the enzyme. However, chemically modified and immobilized enzymes have problems in terms of safety and formulation to be applied, and encapsulated enzymes have problems such as capsule swelling and disintegration in the formulation.

【0007】[0007]

【課題を解決するための手段】本発明者らは、ゼラチン
カプセルに酵素を内包安定化し適度な硬度を付与すれ
ば、カプセル基剤が軟スクラブ剤として機能し、使用時
に内包された酵素が放出され洗浄効果が高まると考え検
討を行った。
Means for Solving the Problems The present inventors have found that when a gelatin capsule is encapsulated with an enzyme to stabilize and impart appropriate hardness, the capsule base functions as a soft scrubbing agent, and the encapsulated enzyme is released at the time of use. It was considered that the cleaning effect would be improved and the examination was conducted.

【0008】その結果、流動パラフィン、スクアラン及
びシリコーンから選ばれる1種以上の油性基剤30〜7
9.9部にプロテアーゼ、リパーゼ及びムラミターゼか
ら選ばれる酵素および固定化酵素0.1〜10部を分散
させた後20〜60部のゼラチンでカプセル化し、カプ
セル重量の0.1〜3重量%のアセトアルデヒド及び/
またはプロピオンアルデヒドで不溶化処理した粒径0.
1〜3mmの酵素内包ゼラチンカプセルをスクラブ剤と
して配合した洗顔料を完成するに至った。
As a result, one or more oily bases 30 to 7 selected from liquid paraffin, squalane and silicone.
An enzyme selected from protease, lipase, and muramitase and 0.1 to 10 parts of immobilized enzyme are dispersed in 9.9 parts, and then encapsulated with 20 to 60 parts of gelatin to obtain 0.1 to 3% by weight of the capsule weight. Acetaldehyde and /
Alternatively, the particle size of the particles insolubilized with propionaldehyde is 0.1.
We have completed a face wash in which 1 to 3 mm gelatin capsules encapsulating an enzyme are blended as a scrubbing agent.

【0009】即ち、本発明の目的は製剤中でゼラチンカ
プセルが安定で、内包された酵素は失活せず、使用時、
カプセル基剤が軟スクラブ剤として機能すると共に崩壊
し、内包された酵素が放出され、洗浄効果が高められる
酵素内包ゼラチンカプセルを配合した洗顔料を提供する
ことにある。
That is, the object of the present invention is that the gelatin capsule is stable in the preparation and the entrapped enzyme is not inactivated.
An object of the present invention is to provide a facial cleanser containing an enzyme-encapsulated gelatin capsule in which the capsule base functions as a soft scrub and disintegrates, the encapsulated enzyme is released, and the cleaning effect is enhanced.

【0010】以下に本発明の構成を詳細に説明する。本
発明の洗顔料は、酵素または固定化酵素を特定の油性基
剤に分散させた後ゼラチンでカプセル化し、適当量のア
セトアルデヒド及び/またはプロピオンアルデヒド処理
して不溶化して得られる特定粒径の酵素内包ゼラチンカ
プセルを配合することを特徴とする。
The structure of the present invention will be described in detail below. The face wash of the present invention is an enzyme having a specific particle size obtained by dispersing an enzyme or an immobilized enzyme in a specific oily base, encapsulating with gelatin, and insolubilizing it by treating with an appropriate amount of acetaldehyde and / or propionaldehyde. It is characterized by containing an encapsulated gelatin capsule.

【0011】本発明の洗顔料に配合される酵素内包ゼラ
チンカプセルに内包させる酵素としては、プロテアー
ゼ、リパーゼ及びムラミターゼが用いられる。また、こ
れらの酵素をシルクフィブロイン、ポリエチレングリコ
ール、デキストラン等の担体に固定化させた固定化酵素
も用いられる。固定化酵素の使用は酵素の安定性を向上
させること、およびカプセル基剤への影響が少ないため
好ましい。
As the enzyme to be encapsulated in the gelatin-encapsulated gelatin capsule to be incorporated in the face wash of the present invention, protease, lipase and muramitase are used. Further, an immobilized enzyme in which these enzymes are immobilized on a carrier such as silk fibroin, polyethylene glycol, dextran, etc. is also used. The use of immobilized enzyme is preferable because it improves the stability of the enzyme and has little influence on the capsule base.

【0012】カプセル中への酵素または固定化酵素の配
合量は酵素内包ゼラチンカプセル総量を基準に0.1%
〜10%が望ましい。0.1%未満では本カプセルを配
合した製剤での酵素活性発現が期待できない。10%を
超える量を配合するとカプセル化が困難になる。
The amount of the enzyme or the immobilized enzyme incorporated into the capsule is 0.1% based on the total amount of the enzyme-encapsulated gelatin capsule.
10% is preferable. If it is less than 0.1%, the expression of enzyme activity cannot be expected in the preparation containing this capsule. If the amount exceeds 10%, encapsulation becomes difficult.

【0013】酵素内包ゼラチンカプセルに用いられる流
動パラフィン及びスクアランは通常化粧料に用いられる
ものでその起源及び製法は特に問わない。また、シリコ
ーンは通常化粧料に用いられるもので、環状ジメチルポ
リシロキサン、ジメチルポリシロキサン、メチルフェニ
ルポリシロキサン等が好ましく、製法、粘度及び重合度
等は特に問わない。これらの1種または2種以上を組み
合わせて用いることが出来る。
The liquid paraffin and squalane used for the enzyme-encapsulated gelatin capsule are generally used for cosmetics, and their origin and production method are not particularly limited. Further, silicone is usually used in cosmetics, and cyclic dimethylpolysiloxane, dimethylpolysiloxane, methylphenylpolysiloxane and the like are preferable, and the production method, viscosity and degree of polymerization are not particularly limited. These can be used alone or in combination of two or more.

【0014】その配合量は酵素内包ゼラチンカプセルの
総量を基準に30%〜79.9%が好ましい。30%未
満では酵素を均一分散させることが困難であり、79.
9%を超える量を配合するとカプセル化が困難になる。
The blending amount thereof is preferably 30% to 79.9% based on the total amount of enzyme-encapsulated gelatin capsules. If it is less than 30%, it is difficult to uniformly disperse the enzyme, and 79.
If the amount exceeds 9%, encapsulation becomes difficult.

【0015】酵素内包ゼラチンカプセルに用いられるゼ
ラチンは医薬品、化粧品及び食品に用いられるゼラチン
でよく起源及び調製方法は問わない。
The gelatin used in the enzyme-encapsulated gelatin capsule may be gelatin used in pharmaceuticals, cosmetics and foods, and its origin and preparation method are not limited.

【0016】その使用量は、酵素内包ゼラチンカプセル
の総量を基準に20%〜60%が好ましい。20%未満
では安定なカプセルを形成出来ず、60%を超える場
合、膜が厚過ぎ適度な硬度のものが得られ難い。
The amount used is preferably 20% to 60% based on the total amount of enzyme-encapsulated gelatin capsules. If it is less than 20%, stable capsules cannot be formed, and if it exceeds 60%, the film is too thick and it is difficult to obtain a film having an appropriate hardness.

【0017】酵素内包ゼラチンカプセルの不溶化処理に
用いられるアセトアルデヒド及び/またはプロピオンア
ルデヒドは通常の合成反応等に用いられるもので良く起
源及び調製方法は問わない。
The acetaldehyde and / or propionaldehyde used for the insolubilization treatment of the enzyme-encapsulated gelatin capsule are those used in ordinary synthetic reactions and the origin and preparation method are not limited.

【0018】処理量は酵素内包ゼラチンカプセル重量の
0.1〜3.0重量%が好ましい。0.1重量%未満で
は、カプセルが柔らか過ぎ、洗顔料に配合し長期間保存
すると製剤中でカプセルが壊れる。3.0重量%を超え
る濃度で処理すると、カプセルが硬過ぎ、洗顔料使用時
に適度な物理的応力で崩壊せず、内包された酵素が放出
されなず、スクラブ剤としても硬すぎ官能上好ましくな
い。不溶化処理に際しては、カプセル表面に均一にアル
デヒド類を作用させるため、エタノール等の溶媒を適宜
用いることが出来る。
The treatment amount is preferably 0.1 to 3.0% by weight based on the weight of the enzyme-encapsulated gelatin capsule. If it is less than 0.1% by weight, the capsule will be too soft, and the capsule will be broken in the preparation when blended in a face wash and stored for a long time. When treated at a concentration of more than 3.0% by weight, the capsules are too hard, do not disintegrate due to moderate physical stress when using face wash, the encapsulated enzyme is not released, and the scrubbing agent is too hard and functionally preferable. Absent. At the time of the insolubilization treatment, a solvent such as ethanol can be appropriately used in order to allow the aldehydes to act uniformly on the capsule surface.

【0019】本発明に用いられる酵素内包ゼラチンカプ
セルの粒径は0.1〜3mmであり、0.2〜1mmが
好ましい。0.1mm未満では内包される酵素の量が制
限されるとともに、生産性が悪くなる。3mmを超える
粒径では使用時に異物感がありスクラブ剤として官能特
性に劣る。
The particle size of the enzyme-encapsulated gelatin capsule used in the present invention is 0.1 to 3 mm, preferably 0.2 to 1 mm. When it is less than 0.1 mm, the amount of the enzyme to be encapsulated is limited and the productivity is deteriorated. If the particle size exceeds 3 mm, a foreign substance may be felt during use and the organoleptic properties of the scrubbing agent may be poor.

【0020】本発明の洗顔料としては、例えば、ボディ
ーソープ、クレンジングクリーム、マッサージクリー
ム、クレンジングローション、化粧石鹸及びクリーミィ
ソープ等が挙げられる。
Examples of the face wash of the present invention include body soap, cleansing cream, massage cream, cleansing lotion, toilet soap and creamy soap.

【0021】本発明の洗顔料に配合する酵素内包ゼラチ
ンカプセルの量は、特に限定されるものでなく、配合す
る製剤の特質により変化するが、好ましくは最終組成物
を基準に0.01〜20重量%である。0.01%未満
では充分なスクラブ効果が得られず、また20%を越え
る濃度を配合しても、配合量に見合った効果が得られな
いばかりでなく、製剤化が困難になる。
The amount of the enzyme-encapsulated gelatin capsule to be blended in the face wash of the present invention is not particularly limited and varies depending on the characteristics of the formulation to be blended, but preferably 0.01 to 20 based on the final composition. % By weight. If it is less than 0.01%, a sufficient scrubbing effect cannot be obtained, and even if the concentration exceeds 20%, not only the effect corresponding to the blending amount cannot be obtained, but also formulation becomes difficult.

【0022】本発明の洗顔料には、酵素内包ゼラチンカ
プセルの他に、適用する製剤に応じて通常用いられる基
剤を適宜配合することができる。
In addition to the enzyme-encapsulated gelatin capsule, a base usually used according to the formulation to be applied can be appropriately incorporated into the face wash of the present invention.

【0023】[0023]

【実施例】以下、実施例及び比較例によって本発明を詳
細に説明する。尚、実施例中の%は特に指定しない場合
重量%を意味する。実施例及び比較例で用いた、保存安
定性試験及びスクラブ剤としての官能評価は、以下の方
法で実施した。
EXAMPLES The present invention will be described in detail below with reference to examples and comparative examples. Incidentally,% in the examples means% by weight unless otherwise specified. The storage stability test and sensory evaluation as a scrubbing agent used in Examples and Comparative Examples were carried out by the following methods.

【0024】(1)保存安定性試験 試料を40℃の恒温層に保存し、直後及び1カ月後の酵
素活性を比較し、直後の酵素活性に対する1カ月後の酵
素活性の百分率で示した。
(1) Storage stability test Samples were stored in a constant temperature layer at 40 ° C., and the enzyme activities immediately after and 1 month after were compared, and shown as a percentage of the enzyme activity after 1 month to the enzyme activity immediately after.

【0025】(2)官能評価 20〜40才の男女パネラー20名による実用テストを
実施し、「スクラブ効果がある」、「異物感又は刺激が
ある」、「洗浄効果が高い」と答えたパネラーの人数を
示した。
(2) Sensory evaluation A practical test was conducted by 20 male and female panelists aged 20 to 40, and the panelists answered that "there is a scrubbing effect", "there is a feeling of foreign matter or irritation", and "the cleaning effect is high". The number of people.

【0026】製造例1(酵素内包ゼラチンカプセル) 表1の組成に従い本発明に用いるプロテアーゼ内包ゼラ
チンカプセルを調製した。
Production Example 1 (Enzyme-encapsulated gelatin capsule) According to the composition shown in Table 1, a protease-encapsulated gelatin capsule used in the present invention was prepared.

【0027】[0027]

【表1】 [Table 1]

【0028】製造方法 環状ジメチルポリシロキサンにプロテアーゼを加え、均
一に混和し内容液とする。ゼラチンに5倍量の水を加
え、加温溶解しカプセル基剤とする。内容液及びカプセ
ル基剤を軟カプセル製造装置を用い、トリ(カプリル・
カプリン酸)グリセリン中に滴下し、カプセルを調製す
る。これを遠心分離し得られたカプセルを室温で気流中
24時間放置する。次に、アセトアルデヒド・エタノー
ル溶液を加え密封容器中で3日間放置する。これに20
倍量の温水を加え3時間洗浄した後室温で24時間乾燥
し、酵素内包ゼラチンカプセルをえる。
Manufacturing Method Protease is added to cyclic dimethylpolysiloxane and mixed uniformly to obtain a content liquid. Add 5 times the amount of water to gelatin and dissolve by heating to make a capsule base. Using the soft capsule manufacturing equipment, the contents liquid and the capsule base are mixed with chicken (capryl.
Capric acid) Glycerin is added dropwise to prepare capsules. This is centrifuged and the resulting capsules are left at room temperature in an air stream for 24 hours. Next, an acetaldehyde-ethanol solution is added and the mixture is left for 3 days in a sealed container. 20 to this
Double the amount of warm water is added, the mixture is washed for 3 hours and then dried at room temperature for 24 hours to obtain enzyme-encapsulated gelatin capsules.

【0029】製造例2(酵素内包ゼラチンカプセル) 表2の組成に従い本発明に用いるムラミターゼ内包ゼラ
チンカプセルを調製した。
Production Example 2 (enzyme-encapsulated gelatin capsule) According to the composition shown in Table 2, a muramitase-encapsulated gelatin capsule used in the present invention was prepared.

【0030】[0030]

【表2】 [Table 2]

【0031】製造方法 環状ジメチルポリシロキサン、スクアラン混合物にムラ
ミターゼを加え、均一に混和し内容液とする。ゼラチン
に5倍量の水を加え、加温溶解しカプセル基剤とする。
内容液及びカプセル基剤を軟カプセル製造装置を用い、
トリ(カプリル・カプリン酸)グリセリン中に滴下し、
カプセルを調製する。これを遠心分離し得られたカプセ
ルを室温で気流中24時間放置する。次に、アセトアル
デヒド・エタノール溶液を加え密封容器中で3日間放置
する。これに20倍量の温水を加え3時間洗浄した後室
温で24時間乾燥し、酵素内包ゼラチンカプセルをえ
る。
Manufacturing Method Muramitase was added to a mixture of cyclic dimethylpolysiloxane and squalane, and the contents were mixed uniformly. Add 5 times the amount of water to gelatin and dissolve by heating to make a capsule base.
Using the soft capsule manufacturing equipment, the content liquid and the capsule base,
Tri (capryl capric acid) Drop into glycerin,
Prepare capsules. This is centrifuged and the resulting capsules are left at room temperature in an air stream for 24 hours. Next, an acetaldehyde-ethanol solution is added and the mixture is left for 3 days in a sealed container. 20 times amount of warm water was added thereto, washed for 3 hours and dried at room temperature for 24 hours to obtain enzyme-encapsulated gelatin capsules.

【0032】 製造例3(固定化酵素内包ゼラチンカプセル) 表3の組成に従い本発明に用いるシルクフィブロイン固
定化リパーゼ内包ゼラチンカプセルを調製した。
Production Example 3 (immobilized enzyme-encapsulated gelatin capsule) According to the composition shown in Table 3, a silk fibroin-immobilized lipase-encapsulated gelatin capsule used in the present invention was prepared.

【0033】[0033]

【表3】 [Table 3]

【0034】製造方法 流動パラフィン、環状ジメチルポリシロキサン混合物に
シルクフィブロイン固定化リパーゼを加え、均一に混和
し内容液とする。ゼラチンに5倍量の水を加え、加温溶
解しカプセル基剤とする。内容液及びカプセル基剤を軟
カプセル製造装置を用い、トリ(カプリル・カプリン
酸)グリセリン中に滴下し、カプセルを調製する。これ
を遠心分離し得られたカプセルを室温で気流中24時間
放置する。次に、アセトアルデヒド・エタノール溶液を
加え密封容器中で3日間放置する。これに20倍量の温
水を加え3時間洗浄した後室温で24時間乾燥し、固定
化酵素内包ゼラチンカプセルをえる。
Manufacturing Method Silk fibroin-immobilized lipase is added to a mixture of liquid paraffin and cyclic dimethylpolysiloxane, and the mixture is uniformly mixed to obtain a content liquid. Add 5 times the amount of water to gelatin and dissolve by heating to make a capsule base. The content liquid and the capsule base are dropped into tri (capryl-capric acid) glycerin using a soft capsule manufacturing apparatus to prepare capsules. This is centrifuged and the resulting capsules are left at room temperature in an air stream for 24 hours. Next, an acetaldehyde-ethanol solution is added and the mixture is left for 3 days in a sealed container. 20 times amount of warm water was added thereto, washed for 3 hours, and dried at room temperature for 24 hours to obtain a gelatin capsule containing immobilized enzyme.

【0035】実施例1〜2(クリーミィソープ) 表4の組成の如く本発明のクリーミィソープを調製し、
上記保存安定性試験及び官能評価を実施した。
Examples 1 and 2 (Creamy soap) The creamy soap of the present invention having the composition shown in Table 4 was prepared,
The above-mentioned storage stability test and sensory evaluation were carried out.

【0036】[0036]

【表4】 [Table 4]

【0037】製造方法 ミリスチン酸、ステアリン酸及びラウリン酸を80℃に
て加温溶解したものに、グリセリン、水酸化カリウム及
び水を均一に混合溶解し80℃まで加温したものを加
え、混合分散する。これを50℃まで冷却し、製造例1
または2の酵素内包ゼラチンカプセルを加え均一に混合
分散した後、室温まで冷却し本発明のクリーミィソープ
を得る。
Production method To a mixture of myristic acid, stearic acid and lauric acid heated and dissolved at 80 ° C., glycerin, potassium hydroxide and water are uniformly mixed and dissolved, and heated to 80 ° C., and then mixed and dispersed. To do. This was cooled to 50 ° C., and Production Example 1
Alternatively, the enzyme-encapsulated gelatin capsule of 2 is added and uniformly mixed and dispersed, and then cooled to room temperature to obtain the creamy soap of the present invention.

【0038】比較例1〜3(クリーミィソープ) 表5の組成の如く比較用のクリーミィソープを調製し、
上記保存安定性試験及び官能評価を実施した。
Comparative Examples 1 to 3 (Creamy Soap) Comparative creamy soaps having the compositions shown in Table 5 were prepared,
The above-mentioned storage stability test and sensory evaluation were carried out.

【0039】[0039]

【表5】 [Table 5]

【0040】製造方法 酵素内包ゼラチンカプセルの代わりにポリエチレンビー
ズ、ポリアクリル酸Naビーズまたはプロテアーゼを用
いる他は実施例1と同様に製造し、比較用のクリーミィ
ソープを得る。
Manufacturing method: A creamy soap for comparison is obtained in the same manner as in Example 1 except that polyethylene beads, sodium polyacrylate beads or protease is used instead of the enzyme-encapsulated gelatin capsule.

【0041】実施例1〜2及び比較例1〜3の保存安定
性試験及び官能評価の結果を表6に示す。
Table 6 shows the results of the storage stability test and the sensory evaluation of Examples 1-2 and Comparative Examples 1-3.

【0042】[0042]

【表6】 [Table 6]

【0043】表6に示した如く本発明のクリーミィソー
プは、保存安定性試験及び官能評価のスクラブ効果及び
洗浄効果においても優れており、刺激・異物感を感じる
と答えたパネラーも少なかった。
As shown in Table 6, the creamy soap of the present invention was excellent also in the scrubbing effect and the cleaning effect in the storage stability test and the sensory evaluation, and few panelists answered that they felt a stimulus or a feeling of foreign matter.

【0044】従来の硬スクラブを用いた比較例1は、ス
クラブ効果には優れているものの、刺激・異物感を感じ
ると答えたパネラーが半数以上を占め、洗浄効果も不十
分であった。一方、従来の軟スクラブを用いた比較例2
は、刺激・異物感は感じないものの、スクラブ効果が不
明確で洗浄効果も不十分であった。
In Comparative Example 1 using the conventional hard scrub, the scrub effect was excellent, but more than half of the panelists answered that they felt irritation or a feeling of foreign matter, and the cleaning effect was insufficient. On the other hand, Comparative Example 2 using a conventional soft scrub
No sense of irritation or foreign matter was felt, but the scrubbing effect was unclear and the cleaning effect was insufficient.

【0045】プロテアーゼをそのまま用いた比較例3
は、保存安定性試験において8.2%と著しい酵素活性
の低下が観察された。
Comparative Example 3 using protease as it is
In the storage stability test, a marked decrease in enzyme activity of 8.2% was observed.

【0046】 実施例3、比較例4(クレンジングクリーム) 表7の組成の如く、本発明のクレンジングクリム及び比
較用のクレンジングクリームを調製し、保存安定性試験
及び官能評価を実施した。
Example 3, Comparative Example 4 (Cleansing Cream) The cleansing cream of the present invention and the cleansing cream for comparison having the compositions shown in Table 7 were prepared, and a storage stability test and a sensory evaluation were performed.

【0047】[0047]

【表7】 [Table 7]

【0048】製造方法 組成中1〜4を80℃にて均一に混合溶解したものに、
5〜7及び10を80℃にて均一に混合溶解したものを
加えて乳化し、50℃にて8または9を加えて均一に分
散し、本発明及び比較用のクレンジングクリームを得
る。
Manufacturing Method 1 to 4 of the composition were uniformly mixed and dissolved at 80 ° C.,
A mixture obtained by uniformly mixing and dissolving 5 to 7 and 10 at 80 ° C. was added to emulsify, and 8 or 9 was added at 50 ° C. to uniformly disperse, to obtain a cleansing cream for the present invention and for comparison.

【0049】実施例3及び比較例4の保存安定性試験及
び官能評価結果を表8に示す。
Table 8 shows the results of the storage stability test and the sensory evaluation of Example 3 and Comparative Example 4.

【0050】[0050]

【表8】 [Table 8]

【0051】表8に示した如く本発明のクレンジングク
リームは、保存安定性試験において95.5と極めて安
定であり、官能評価においても優れていた。比較例4
は、保存安定性試験においては許容範囲であるが、官能
評価においてスクラブ効果がないのはもちろんである
が、シルクフィブロイン固定化酵素が製剤中で不均一に
会合するため、異物感を感じるパネラーがおり好ましく
なく、洗浄効果もやや劣っていた。
As shown in Table 8, the cleansing cream of the present invention was extremely stable at 95.5 in the storage stability test and was excellent in sensory evaluation. Comparative Example 4
Is a permissible range in the storage stability test, but of course, there is no scrubbing effect in the sensory evaluation, but since the silk fibroin-immobilized enzyme associates unevenly in the formulation, the panelists who feel a foreign body feel However, the cleaning effect was slightly inferior.

【0052】実施例4(ボディーソープ) 表9の組成の通り、定法に従って本発明のボディーソー
プ調製した。
Example 4 (Body Soap) The body soap of the present invention was prepared according to a conventional method having the composition shown in Table 9.

【0053】[0053]

【表9】 [Table 9]

【0054】本発明のボディーソープは保存安定性試験
において92.6%と優れており、官能評価においても
良好な結果であった。
The body soap of the present invention was excellent at 92.6% in the storage stability test, and was also good in the sensory evaluation.

【0055】[0055]

【発明の効果】以上記載の如く、本発明の酵素内包ゼラ
チンカプセルを配合した洗顔料は、製剤中ではゼラチン
カプセルが安定で、内包された酵素は失活せず、使用
時、カプセル基剤が軟スクラブ剤として機能すると共に
崩壊し、内包された酵素が放出され、洗浄効果が高めら
れることは明かである。
As described above, the facial cleanser containing the enzyme-encapsulated gelatin capsule of the present invention has a stable gelatin capsule in the preparation, does not deactivate the encapsulated enzyme, and has a capsule base at the time of use. It is clear that it functions as a soft scrub and disintegrates, releasing the entrapped enzyme and enhancing the cleaning effect.

フロントページの続き (72)発明者 柏木 尊紀 静岡県富士宮市大岩1562番地の2 (72)発明者 近藤 隆 静岡県清水市入江3丁目10番21号Front page continuation (72) Inventor Takanori Kashiwagi 2 1562 Oiwa, Fujinomiya-shi, Shizuoka Prefecture 2 (72) Inventor Takashi Kondo 3-10-21 Irie, Shimizu City Shizuoka Prefecture

Claims (2)

【特許請求の範囲】[Claims] 【請求項1】 流動パラフィン、スクアラン、シリコー
ンの1種以上を30〜79.9部、プロテアーゼ、リパ
ーゼ、ムラミターゼから選ばれる酵素を0.1〜10
部、ゼラチンを20〜60部配合してなるゼラチンカプ
セルをカプセル重量に対して0.1〜3%のアセトアル
デヒド及び/またはプロピオンアルデヒドで不溶化して
得られる粒径0.1〜3.0mmの酵素内包ゼラチンカ
プセルをスクラブ剤として配合することを特徴とする洗
顔料。
1. One to at least one of liquid paraffin, squalane, and silicone is contained in an amount of 30 to 79.9 parts, and an enzyme selected from protease, lipase, and muramitase is added in an amount of 0.1 to 10.
Enzyme having a particle size of 0.1 to 3.0 mm obtained by insolubilizing a gelatin capsule formed by mixing 20 parts to 60 parts of gelatin with 0.1 to 3% of acetaldehyde and / or propionaldehyde with respect to the capsule weight. A facial cleanser characterized by containing an encapsulated gelatin capsule as a scrubbing agent.
【請求項2】 固定化酵素を内包した酵素内包ゼラチン
カプセルをスクラブ剤として配合する請求項1記載の洗
顔料。
2. The face wash according to claim 1, wherein an enzyme-encapsulating gelatin capsule containing an immobilized enzyme is blended as a scrubbing agent.
JP5157493A 1993-02-16 1993-02-16 Facial cleansing agent Pending JPH06239733A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP5157493A JPH06239733A (en) 1993-02-16 1993-02-16 Facial cleansing agent

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP5157493A JPH06239733A (en) 1993-02-16 1993-02-16 Facial cleansing agent

Publications (1)

Publication Number Publication Date
JPH06239733A true JPH06239733A (en) 1994-08-30

Family

ID=12890726

Family Applications (1)

Application Number Title Priority Date Filing Date
JP5157493A Pending JPH06239733A (en) 1993-02-16 1993-02-16 Facial cleansing agent

Country Status (1)

Country Link
JP (1) JPH06239733A (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008010402A1 (en) * 2006-07-20 2008-01-24 Kao Corporation Hydrogel particle
JP2008024636A (en) * 2006-07-20 2008-02-07 Kao Corp Hydrogel particle
JP2008088110A (en) * 2006-10-02 2008-04-17 Kao Corp Hydrogel particle
JP2009137966A (en) * 2007-12-10 2009-06-25 Takasago Internatl Corp Body cleansing method

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62220598A (en) * 1986-03-22 1987-09-28 関西酵素株式会社 Sanitary product containing encapsulated enzyme
JPS63185914A (en) * 1987-01-28 1988-08-01 Pola Chem Ind Inc Scrubbing face-washing cosmetic

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS62220598A (en) * 1986-03-22 1987-09-28 関西酵素株式会社 Sanitary product containing encapsulated enzyme
JPS63185914A (en) * 1987-01-28 1988-08-01 Pola Chem Ind Inc Scrubbing face-washing cosmetic

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008010402A1 (en) * 2006-07-20 2008-01-24 Kao Corporation Hydrogel particle
JP2008024636A (en) * 2006-07-20 2008-02-07 Kao Corp Hydrogel particle
US8222193B2 (en) 2006-07-20 2012-07-17 Kao Corporation Hydrogel particles
TWI422426B (en) * 2006-07-20 2014-01-11 Kao Corp Method for manufacturing hydrogel particles
JP2008088110A (en) * 2006-10-02 2008-04-17 Kao Corp Hydrogel particle
JP2009137966A (en) * 2007-12-10 2009-06-25 Takasago Internatl Corp Body cleansing method

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