CN108125857A - A kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof - Google Patents

A kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof Download PDF

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CN108125857A
CN108125857A CN201810022876.4A CN201810022876A CN108125857A CN 108125857 A CN108125857 A CN 108125857A CN 201810022876 A CN201810022876 A CN 201810022876A CN 108125857 A CN108125857 A CN 108125857A
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hand cleanser
skin
hand
graceful
sha
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CN108125857B (en
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杨水波
郭伊妮
李荣杰
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Walch (guangzhou) Daily Articles Co Ltd
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Walch (guangzhou) Daily Articles Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A61K8/442Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof substituted by amido group(s)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/84Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
    • A61K8/86Polyethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/005Preparations for sensitive skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/10Washing or bathing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/59Mixtures
    • A61K2800/592Mixtures of compounds complementing their respective functions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/75Anti-irritant

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Abstract

The invention belongs to daily necessities fields, and in particular to a kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof is made of following components and its weight percent:The deionized water of laureth sodium sulfovinate 3 7%, lauroylamidopropyl betaine 6 12%, sodium lauroyl sarcosine 2 5%, Sha are of ancient India graceful 1 3%, skin is releived composition 5 12%, Monoolein 0.3 0.8%, silicone emulsion 0.02 0.05%, citric acid 0.1 0.2%, parachlorometaxylenol 0.1 0.3%, Coconut Fatty Acid Monoethanolamide 0.2 0.5%, salicylic acid 0.1 0.5%, essence 0.1 0.3%, 75~80% ethanol solutions 0.3~1% and surplus.Hand cleanser of the present invention has the advantages that blistering is fast, defoaming is fast, and it is 6min, and the hand cleanser is small to the irritation of sensitive, can be used for a long time that the residual foam extinction time of hand washing sink is most short after washing one's hands.

Description

A kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof
Technical field
The invention belongs to daily necessities fields, and in particular to a kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof.
Background technology
Surfactant is most important cleansing in cleaning products, and general surfactant usually has a water-wet side (being attracted on hydrone) and a hydrophobic side (it is combined while repelling water with the grease in dirt).When these have parent simultaneously When water end (W.E.) and the surfactant of hydrophobic side are dissolved in water, which imparts the performances that product can remove dirt.
With the raising of people's quality of life and the concern to health, foam type bacteriostatic hand sanitizer is increasingly by consumer Favor.The richness of foam would generally add in largely when foam type bacteriostatic hand sanitizer of the prior art is washed one's hands to pursue Anion surfactant, the most commonly used is AES, general dosage is more than 10%.It is this to live containing high level anionic surface The hand cleanser of property agent, can generate abundant foam when in use.But its there are one it is serious the drawbacks of, most consumers It is reflected in after having used this hand cleanser, since a large amount of foam of generation can not dissipate in a short time, needs with a large amount of Water rinses remaining foam, is on the one hand serious waste for water resource, and on the other hand, the foam washed out by water is not due to Have and be effectively destroyed, after repeatedly washing one's hands, may result in these foams and spilt into hand washing sink by the way that sewer pipe is counter, influence Beautiful and health.
And the problem of can not being deteriorated in time for foam, it is feasible to attempt to add in antifoaming agent, but adds and disappear Foaming abundancy degree infusion can reduce lather quickness when washing one's hands and wash one's hands again when.Therefore, how ensure wash one's hands when The technical issues of residual foam rapid dispersion being made to be current urgent need to resolve again while lather quickness and foaming abundancy are spent.
In addition, AES is common surfactant, with good blistering and effect of deoiling, if but for directly connecing When touching skin product, during hand cleanser particularly containing high level AES, the sebum of skin surface is easily taken away, is caused quick Perceptual skin person generates uncomfortable and aggravates stimulation, and therefore, there is an urgent need for a kind of small hand cleanser of stimulation to sensitive subjects skin at present.
Invention content
The present invention is intended to provide a kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof, which has blistering Soon, foaming abundancy, and the residual foam after washing one's hands easily dissipates, at the same sensibility skin is stimulated it is small, suitable for promoting on a large scale Using.
In order to achieve the above object, the present invention uses following technical scheme:A kind of novel quick defoaming bacteriostatic hand sanitizer, by Following components and its weight percent composition:Laureth sodium sulfovinate 3-7%, lauroylamidopropyl betaine 6-12%, Sodium lauroyl sarcosine 2-5%, Sha graceful 1-3% of ancient India, skin are releived composition 5-12%, Monoolein 0.3-0.8%, breast SiClx oil 0.02-0.05%, citric acid 0.1-0.2%, parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.5%, salicylic acid 0.1-0.5%, essence 0.1-0.3%, 75~80% ethanol solutions 0.3~1% and surplus are gone Ionized water.
Further, the hand cleanser is made of following components and its weight percent:Laureth sodium sulfovinate 5- 7%th, lauroylamidopropyl betaine 6-10%, sodium lauroyl sarcosine 3-5%, Sha graceful 1-3% of ancient India, skin are releived composition 5- 10%th, Monoolein 0.3-0.6%, silicone emulsion 0.02-0.05%, citric acid 0.1-0.2%, parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.4%, salicylic acid 0.1-0.3%, essence 0.1-0.3%, 75~80% second The deionized water of alcoholic solution 0.5~1% and surplus.
Further, the hand cleanser is made of following components and its weight percent:Laureth sodium sulfovinate 5%th, lauroylamidopropyl betaine 9%, sodium lauroyl sarcosine 3%, Sha be of ancient India graceful 2%, skin is releived composition 8%, glycerine Monoleate 0.6%, silicone emulsion 0.04%, citric acid 0.15%, parachlorometaxylenol 0.2%, coconut oil monoethanol acyl Amine 0.35%, salicylic acid 0.3%, essence 0.2%, 75~80% ethanol solutions 0.8% and surplus deionized water.
Further, the hand cleanser is made of following components and its weight percent:Laureth sodium sulfovinate 5%th, lauroylamidopropyl betaine 6%, sodium lauroyl sarcosine 3%, Sha be of ancient India graceful 1%, skin is releived composition 5%, glycerine Monoleate 0.3%, silicone emulsion 0.02%, citric acid 0.1%, parachlorometaxylenol 0.1%, Coconut Fatty Acid Monoethanolamide 0.2%th, the deionized water of salicylic acid 0.1%, essence 0.1%, 75~80% ethanol solutions 0.5% and surplus.
Further, the hand cleanser is made of following components and its weight percent:Laureth sodium sulfovinate 7%th, it is lauroylamidopropyl betaine 10%, sodium lauroyl sarcosine 5%, Sha be of ancient India graceful 3%, skin is releived composition 10%, sweet Oily monoleate 0.6%, silicone emulsion 0.05%, citric acid 0.2%, parachlorometaxylenol 0.3%, coconut oil monoethanol acyl Amine 0.4%, salicylic acid 0.3%, essence 0.3%, 75~80% ethanol solutions 1% and surplus deionized water.
Further, the skin releive composition be comprising 5~15wt% go chlorophyll green-tea extract, 0.1~ The aqueous solution of 1wt% nonpolar amino acids and 5~10wt% Rosmarinus officinalis extracts.
Further, the skin releives composition to go to the non-pole of chlorophyll green-tea extract, 0.4wt% comprising 12wt% The aqueous solution of acidic amino acid and 8wt% Rosmarinus officinalis extracts.
Further, the one kind of the nonpolar amino acid in leucine, valine and phenylalanine.
Further, the nonpolar amino acid is selected from leucine.
Further, it is described that chlorophyll green-tea extract is gone to be made by following steps:
S1, fresh green tea is taken to clean, shade is dry, crushes, and adds in 60~80% ethanol solution of 2~5 times of amounts of green tea total amount Extraction 1~3 time merges, obtains ethanol extract;
S2, above-mentioned ethanol extract is washed till flow liquid without muddy by D152 resin columns, and with 60~80% ethanol solution It is turbid, collect flow liquid to get.
Further, institute's Rosmarinus officinalis extract is made by following steps:It is crushed after taking rosemary blade, shade dry, adds in fan The repeatedly water of fragrant 2~5 times of amounts of total amount, decoct 1~3 time, filtering, merging filtrate to get.
Correspondingly, the present invention also provides a kind of method for preparing above-mentioned hand cleanser, include the following steps:
Parachlorometaxylenol and salicylic acid first are dissolved with ethanol solution, obtains mixed solution, it is spare;It is added in 1/2 water Laureth sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, Buddhist Sha are graceful, Monoolein and breast SiClx oil, stirring is to being completely dissolved;It sequentially adds Coconut Fatty Acid Monoethanolamide, salicylic acid and skin to releive composition, stirring Uniformly, the water of above-mentioned mixed solution, essence and surplus is then added in, stirring is eventually adding lemon acid for adjusting pH, i.e., to dissolving ..
Further, the pH of the hand cleanser is 4.0-4.6.
Further, the viscosity of the hand cleanser is 1500-3000cps.
At the beginning, the technical thought that inventor provides is with laureth sodium sulfovinate (AES), dodecanamide propyl sweet tea As surfactant, wherein laureth sodium sulfovinate is used as primary surfactant for dish alkali and sodium lauroyl sarcosine It is 10~15% to measure, and undertakes main barbotage, and three's compounding can reach higher lather quickness and enough foams Richness, but there are one it is serious the drawbacks of:A large amount of residual foam is difficult to short time dissipation after washing one's hands.Therefore, it invents People attempts to add in Monoolein and silicone emulsion, and experiment proves that the movement is feasible, adds antifoaming agent and greatly drop The low stability of residual foam makes remaining foam be easier to dissipate, and residual foam dissipates substantially after 12min, but again Occur one it is new the problem of:Antifoaming agent is added to result in the decline of lather quickness and foaming abundancy degree (initial bubble is high only For 121mm).And this problem is also that cannot effectively solve the problems, such as always in the art at present, inventor is attempting to solve Certainly during the above problem, look for another way, add a kind of cyclic lipopeptide surfactant, Buddhist Sha is graceful, it has unexpectedly been found that, it should The addition of cyclic lipopeptide surfactant produces following effect:Even if adding antifoaming agent, the lather quickness and bubble of hand cleanser The richness of foam remains within ideal level, and the initial height that steeps can reach 195mm, and residual foam extinction time is 6min, especially it is surprising that this effect can also be reached by not needing to add in a large amount of AES (content is 3~7%) in hand cleanser Fruit greatly reduces the dosage of AES, is truly realized that blistering is fast, defoaming also fast effect.
And it be emphasized that the application can obtain said effect, it may be possible to because of the group of surfactant of the present invention It is different to close type, the general prior art is with anion surfactant, nonionic surfactant or amphoteric surfactant One or more of collocation form surfactant system, and what the present inventor took is and above-mentioned entirely different think of Road, present invention adds cyclic lipopeptide surfactant, exactly because may this difference just achieve it is above-mentioned unexpected Effect.
Another key point is to add skin in hand cleanser and releives composition in the present invention, main function be for Reducing AES when hand cleanser is used for a long time stimulates caused by sensitive.Experiment proves, using adding skin of the present invention Releive composition when, smooth feeling and moisture feeling are apparent, and non-stimulated to sensitive skin.
The present invention has the following advantages:
1) hand cleanser of the present invention has the advantages that blistering is fast, defoams fast, the residual foam extinction time of hand washing sink after washing one's hands Most short is 6min, and the residual foam extinction time of commercially available hand cleanser is 23min, and the hand cleanser is to the thorn of sensitive It is small to swash property, can be used for a long time.
2) present invention is arranged in pairs or groups with laureth sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine 3% Sha's graceful formation surfactant package of ancient India, is aided with antifoaming agent, forms a kind of blistering, defoams fast system, with prior art phase Than achieving significant progress.
3) it releives composition the present invention also provides a kind of skin, AES can be reduced in hand cleanser to sensitive Stimulation.
Specific embodiment
The specific embodiment of form by the following examples makees further specifically the above of the present invention It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
Sha's graceful molecular formula of ancient India is C53H93N7O13, is bought in Beijing Geordie Asia Bioisystech Co., Ltd, article No. S3523.
Embodiment 1, the preparation for removing chlorophyll green-tea extract
S1, fresh green tea is taken to clean, shade is dry, crushes, and 75% ethanol solution for adding in 3 times of amounts of green tea total amount extracts 2 times, Merge, obtain ethanol extract;
S2, above-mentioned ethanol extract is washed till flow liquid without muddiness by D152 resin columns, and with 75% ethanol solution, received Flow liquid is taken to get wherein amount of resin and liquid ratio are 1:3.
The preparation of embodiment 2, repeatedly fragrant extract
It is crushed after taking rosemary blade, shade dry, adds in the water of 5 times of amounts of rosemary total amount, decocted 3 times, filtering merges filter Liquid to get.
The preparation of embodiment 3, green-tea extract
Difference lies in remove step S2, remaining parameter and operation are as described in Example 1 with embodiment 1.
Embodiment 4, a kind of novel bacteriostatic hand sanitizer quickly defoamed
Laureth sodium sulfovinate 5%, lauroylamidopropyl betaine 9%, sodium lauroyl sarcosine 3%, Buddhist Sha are graceful 2%th, skin releive composition 8%, Monoolein 0.6%, silicone emulsion 0.04%, citric acid 0.15%, two between chlorine Cresols 0.2%, Coconut Fatty Acid Monoethanolamide 0.35%, salicylic acid 0.3%, essence 0.2%, 75% ethanol solution 0.8% with And the deionized water of surplus, the skin releive composition be comprising gone described in 12wt% embodiments 1 chlorophyll green-tea extract, The aqueous solution of Rosmarinus officinalis extract described in 0.4wt% leucines and 8wt% embodiments 2.
Preparation method:
Parachlorometaxylenol and salicylic acid first are dissolved with ethanol solution, obtains mixed solution, it is spare;It is added in 1/2 water Laureth sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, Buddhist Sha are graceful, Monoolein and breast SiClx oil, stirring is to being completely dissolved;It sequentially adds Coconut Fatty Acid Monoethanolamide, salicylic acid and skin to releive composition, stirring Uniformly, the water of above-mentioned mixed solution, essence and surplus is then added in, to dissolving, being eventually adding lemon acid for adjusting pH is for stirring 4.5 to get.
Embodiment 5, a kind of novel bacteriostatic hand sanitizer quickly defoamed
Laureth sodium sulfovinate 5%, lauroylamidopropyl betaine 6%, sodium lauroyl sarcosine 3%, Buddhist Sha are graceful 1%th, skin is releived composition 5%, Monoolein 0.3%, silicone emulsion 0.02%, citric acid 0.1%, the diformazan between chlorine Phenol 0.1%, Coconut Fatty Acid Monoethanolamide 0.2%, salicylic acid 0.1%, essence 0.1%, 75~80% ethanol solutions 0.5% with And the deionized water of surplus;The skin releive composition be comprising gone described in 6wt% embodiments 1 chlorophyll green-tea extract, The aqueous solution of Rosmarinus officinalis extract described in 0.2wt% valines and 5wt% embodiments 2.
Preparation method reference implementation example 4.
Embodiment 6, a kind of novel bacteriostatic hand sanitizer quickly defoamed
Laureth sodium sulfovinate 7%, lauroylamidopropyl betaine 10%, sodium lauroyl sarcosine 5%, Buddhist Sha are graceful 3%th, skin releive composition 10%, Monoolein 0.6%, silicone emulsion 0.05%, citric acid 0.2%, two between chlorine Cresols 0.3%, Coconut Fatty Acid Monoethanolamide 0.4%, salicylic acid 0.3%, essence 0.3%, 75~80% ethanol solutions 1% with And the deionized water of surplus;The skin releive composition be comprising gone described in 15wt% embodiments 1 chlorophyll green-tea extract, The aqueous solution of Rosmarinus officinalis extract described in 0.4wt% phenylalanines and 10wt% embodiments 2.
Preparation method reference implementation example 4.
Comparative example 1, a kind of novel bacteriostatic hand sanitizer quickly defoamed
Difference lies in it is graceful to remove Buddhist Sha, remaining parameter and operation are as described in Example 4 with embodiment 4.
Comparative example 2, a kind of novel bacteriostatic hand sanitizer quickly defoamed
Difference lies in graceful, remaining parameters that substitutes Buddhist Sha with cyclic lipopeptide type surfactant surfaction with embodiment 4 And operation is as described in Example 4.
Comparative example 3, a kind of novel bacteriostatic hand sanitizer quickly defoamed
With embodiment 4 difference lies in, with lauryl sodium sulfate substitute laureth sodium sulfovinate, remaining parameter and Operation is as described in Example 4.
Comparative example 4, a kind of novel bacteriostatic hand sanitizer quickly defoamed
Difference lies in the skin releives composition to be extracted comprising green tea described in 12wt% embodiments 3 with embodiment 4 The aqueous solution of object, 0.4wt% leucines and Rosmarinus officinalis extract described in 8wt% embodiments 2.
Test example one, foam performance experiment
1. sample:(droplet dew health is antibacterial for hand cleanser and commercially available hand cleanser prepared by embodiment 4~6 and comparative example 1~3 Hand cleanser).
2.Ross-Miles methods measure foaming properties:Example 4~6, comparative example 1~3 and the configuration of commercially available hand cleanser Into the sample solution of 0.02% solubility, take each sample solutions of 200ml from high 900mm, internal diameter 2.9mm pore in flow down, pour With in mutually synthermal and concentration 50ml sample solutions, foam height when record has flowed 200ml sample solutions is used as tested The foaming power evaluation index of experiment, blister 5min after evaluation index of the foam height as foam stability, and record each group steep Foam completely disappears the time.
3. test result:Test result is as shown in table 1:
1 foam performance result of the test of table
Classification Initial bubbles height (mm) Foam height (mm) after blistering 5min Residual foam extinction time (min)
Droplet dew 136 102 23
Embodiment 4 195 5 6
Embodiment 5 189 5 6
Embodiment 6 186 6 6
Comparative example 1 127 72 15
Comparative example 2 133 60 12
Comparative example 3 152 51 10
Note:Initial bubbles height is bigger to represent that foaming abundancy degree is bigger;Foam height is smaller after blistering 5min, represents foam Stability is poor, and antifoaming speed is fast.
As shown in Table 1, compared with commercially available hand cleanser, 4~6 hand cleanser of the embodiment of the present invention has excellent foam performance, Its initial bubbles highly can reach 195mm, 6min or so residual foams and disappear substantially, and commercially available hand cleanser initial bubbles are high It spends for 136mm, foam vanishing time needs 23min, and in contrast, what hand cleanser of the present invention had reached truly quick rises Bubble has both the effect quickly defoamed.
It should be pointed out that the initial bubble of comparative example 1 (it is graceful compared with Example 4, to be added without Buddhist Sha) described hand cleanser is high 34.8% is reduced compared with Example 4, although it compared with commercially available hand cleanser, foam time is shortened, with implementation For example 4 compared to 9min is extended, this explanation, Sha's graceful addition of ancient India can significantly improve foaming abundancy degree when washing one's hands, and can also Enough reduce the stability of residual foam.
The initial bubble Gao Yushi of comparative example 2 (compared with Example 4, substitute Buddhist Sha with the surfaction graceful) hand cleanser Example 4 is applied compared to reducing 31.7%, foam vanishing time extends 8min, this explanation, not all cyclic lipopeptide surface Activating agent is washed one's hands liquid system suitable for the present invention, and compared with surfaction, Sha graceful present invention that is more suitable for of ancient India washes one's hands liquid System.
The initial bubble of comparative example 3 (compared with Example 4, substitute Buddhist Sha with the lauryl sodium sulfate graceful) hand cleanser is high 22.1% is reduced compared with Example 4, and foam vanishing time extends 4min.
Test example two, using effect experiment
2.1 sensory effects are evaluated
2.1.1 sample:The hand cleanser that the embodiment of the present invention 4~6 and comparative example 4 are prepared.
40 testers are equally divided into 10 groups, give specimen sample at random, it is desirable that tester is daily according to itself Custom of washing one's hands is washed one's hands, smooth feeling, moisture feeling and irritation when washing one's hands successively according to 2 evaluation criterion of table evaluation each group sample, It finally scores by each sample sensory effects of mean values, evaluation result is as shown in table 3.
2 evaluation criterion of table
Project 1~3 point 4~6 points 7~9 points
Smooth feeling Without smooth feeling Smooth feeling is general Smooth feeling is apparent
Moisture feeling Without moisture feeling Moisture feeling is general Moisture feeling is apparent
Irritation Stimulation is strong There are minimal irritations It is non-stimulated
3 evaluation result of table
Group Smooth feeling Moisture feeling Irritation
Embodiment 4 9.2 9.5 9.8
Embodiment 5 9.0 9.3 9.6
Embodiment 6 8.9 9.0 9.2
Comparative example 4 7.4 8.2 5.9
As shown in Table 3, when 10 groups of subjects are thought using 4~6 hand cleanser of the embodiment of the present invention, smooth feeling, moisture feeling Significantly, and irritation is small, and comparative example 4 (compared with Example 4, removing chlorophyll green-tea extract with green-tea extract replacement) is washed Smooth feeling, the moisture feeling of hand liquid decreased significantly than embodiment 4, and 10 groups of subjects think comparative example 4 is being used to wash one's hands There are slight excitements during liquid.
2.2 fungistatic effects are evaluated
1. sample:Hand cleanser prepared by embodiment 4~6 and comparative example 1~4.
2. test method:According to《Disinfection technology standard》Staphylococcus aureus, Escherichia coli and Candida albicans are made For bacteriostatic test object, experimental concentration is hand cleanser stoste, and action time 1min, experimental temperature is 18-22 DEG C, is calculated antibacterial Rate (%), experiment are averaged in triplicate.
3. test result:Test result is as shown in table 4:
4 bacteriostatic test test result of table
By table 3,4 it is found that 4~6 hand cleanser of the embodiment of the present invention is to staphylococcus aureus, Escherichia coli and Candida albicans Bacterium is respectively provided with preferable fungistatic effect, meets the requirement of antibacterial disinfection.Wherein 4 fungistatic effect of embodiment is best, is of the invention Most preferred embodiment.Significantly decline it is surprising that the fungistatic effect of comparative example 4 has compared with Example 4, this illustrates this hair The releive variation of composition component of bright skin can influence the fungistatic effect of hand cleanser.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe The personage for knowing this technology all can carry out modifications and changes under the spirit and scope without prejudice to the present invention to above-described embodiment.Cause This, those of ordinary skill in the art is complete without departing from disclosed spirit and institute under technological thought such as Into all equivalent modifications or change, should by the present invention claim be covered.

Claims (10)

1. a kind of novel quick defoaming bacteriostatic hand sanitizer, which is characterized in that be made of following components and its weight percent:Bay Alcohol polyethers sodium sulfovinate 3-7%, lauroylamidopropyl betaine 6-12%, sodium lauroyl sarcosine 2-5%, Sha graceful 1-3% of ancient India, Skin is releived composition 5-12%, Monoolein 0.3-0.8%, silicone emulsion 0.02-0.05%, citric acid 0.1- 0.2%th, parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.5%, salicylic acid 0.1-0.5%, essence The deionized water of 0.1-0.3%, 75~80% ethanol solutions 0.3~1% and surplus.
2. hand cleanser as described in claim 1, which is characterized in that be made of following components and its weight percent:Laruyl alcohol Polyethers sodium sulfovinate 5-7%, lauroylamidopropyl betaine 6-10%, sodium lauroyl sarcosine 3-5%, Sha graceful 1-3% of ancient India, skin Skin releive composition 5-10%, Monoolein 0.3-0.6%, silicone emulsion 0.02-0.05%, citric acid 0.1-0.2%, Parachlorometaxylenol 0.1-0.3%, Coconut Fatty Acid Monoethanolamide 0.2-0.4%, salicylic acid 0.1-0.3%, essence 0.1- 0.3%th, the deionized water of 75~80% ethanol solutions 0.5~1% and surplus.
3. hand cleanser as described in claim 1, which is characterized in that be made of following components and its weight percent:Laruyl alcohol Group that polyethers sodium sulfovinate 5%, lauroylamidopropyl betaine 9%, sodium lauroyl sarcosine 3%, Sha are of ancient India graceful 2%, skin is releived Close object 8%, Monoolein 0.6%, silicone emulsion 0.04%, citric acid 0.15%, parachlorometaxylenol 0.2%, coconut palm Oleic monoethanolamide 0.35%, salicylic acid 0.3%, essence 0.2%, 75~80% ethanol solutions 0.8% and surplus are gone Ionized water.
4. the hand cleanser as described in claims 1 to 3 is any, which is characterized in that the skin releive composition be comprising 5~ 15wt% goes the water-soluble of chlorophyll green-tea extract, 0.1~1wt% nonpolar amino acids and 5~10wt% Rosmarinus officinalis extracts Liquid.
5. hand cleanser as claimed in claim 4, which is characterized in that the skin releive composition be comprising 12wt% defoliations it is green The aqueous solution of plain green-tea extract, 0.4wt% nonpolar amino acids and 8wt% Rosmarinus officinalis extracts.
6. hand cleanser as claimed in claim 5, which is characterized in that the nonpolar amino acid be selected from leucine, valine and One kind in phenylalanine.
7. hand cleanser as claimed in claim 4, which is characterized in that described to remove chlorophyll green-tea extract by following steps system :
S1, fresh green tea is taken to clean, shade is dry, crushes, and adds in 60~80% ethanol solution extraction 1 of 2~5 times of amounts of green tea total amount ~3 times, merge, obtain ethanol extract;
S2, above-mentioned ethanol extract is washed till flow liquid without muddiness by D152 resin columns, and with 60~80% ethanol solution, received Take flow liquid to get.
8. hand cleanser as claimed in claim 4, which is characterized in that institute's Rosmarinus officinalis extract is made by following steps:Fan is taken to change Spiceleaf piece crushes after shade is dry, adds in the water of 2~5 times of amounts of rosemary total amount, decocts 1~3 time, filtering, merging filtrate to get.
9. such as the preparation method of claim 1~8 any one of them hand cleanser, which is characterized in that include the following steps:
Parachlorometaxylenol and salicylic acid first are dissolved with ethanol solution, obtains mixed solution, it is spare;Bay is added in 1/2 water Alcohol polyethers sodium sulfovinate, lauroylamidopropyl betaine, sodium lauroyl sarcosine, Buddhist Sha are graceful, Monoolein and emulsification silicon Oil, stirring is to being completely dissolved;It sequentially adds Coconut Fatty Acid Monoethanolamide, salicylic acid and skin to releive composition, stir evenly, Then add in the water of above-mentioned mixed solution, essence and surplus, stirring to dissolving, be eventually adding lemon acid for adjusting pH to get.
10. the preparation method of hand cleanser as claimed in claim 9, which is characterized in that the pH of the hand cleanser is 4.0-4.6; The viscosity of the hand cleanser is 1500-3000cps.
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