CN106667795A - Soluble cleansing paper with deep cleaning effect and preparation method thereof - Google Patents
Soluble cleansing paper with deep cleaning effect and preparation method thereof Download PDFInfo
- Publication number
- CN106667795A CN106667795A CN201710065848.6A CN201710065848A CN106667795A CN 106667795 A CN106667795 A CN 106667795A CN 201710065848 A CN201710065848 A CN 201710065848A CN 106667795 A CN106667795 A CN 106667795A
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- China
- Prior art keywords
- starch
- soluble
- added
- cleaning effect
- deep layer
- Prior art date
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- Granted
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- 238000004140 cleaning Methods 0.000 title claims abstract description 109
- 230000000694 effects Effects 0.000 title claims abstract description 29
- 238000002360 preparation method Methods 0.000 title abstract description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 38
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- 235000019813 microcrystalline cellulose Nutrition 0.000 claims abstract description 25
- 239000008108 microcrystalline cellulose Substances 0.000 claims abstract description 25
- 229940016286 microcrystalline cellulose Drugs 0.000 claims abstract description 25
- 150000001768 cations Chemical class 0.000 claims abstract description 17
- 229920006320 anionic starch Polymers 0.000 claims abstract description 7
- 229920002472 Starch Polymers 0.000 claims description 44
- 239000008107 starch Substances 0.000 claims description 44
- 235000019698 starch Nutrition 0.000 claims description 44
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 36
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- 238000006243 chemical reaction Methods 0.000 claims description 23
- 238000003756 stirring Methods 0.000 claims description 21
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 18
- POJWUDADGALRAB-UHFFFAOYSA-N allantoin Chemical compound NC(=O)NC1NC(=O)NC1=O POJWUDADGALRAB-UHFFFAOYSA-N 0.000 claims description 18
- 241000723343 Cichorium Species 0.000 claims description 16
- 229920001202 Inulin Polymers 0.000 claims description 16
- 229940029339 inulin Drugs 0.000 claims description 16
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims description 16
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- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 12
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 6
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- 239000004471 Glycine Substances 0.000 claims description 3
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Classifications
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/008—Preparations for oily skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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Abstract
The invention belongs to the field of cosmetics, and particularly relates to soluble cleansing paper with deep cleaning effect and a preparation method thereof. The invention adopts soluble anionic starch and cation nano microcrystalline cellulose as a carrier to prepare the soluble cleansing paper, and the soluble cleansing paper is prepared from natural materials and has the advantages of being small in volume, convenient to carry, rapid in dissolving speed, good in cleaning effect. The soluble cleansing paper has the thickness of only 0.2 to 0.3mm and a wide application prospect, the cleansing paper can be just dissolved with clean water when being used, and the face is not tight after cleaning.
Description
Technical field
The invention belongs to cosmetic field, and in particular to a kind of soluble cleaning tissue and its system with deep layer cleaning effect
Preparation Method.
Background technology
Cleaning cosmetics is essential daily necessities in human lives, is special face skin, have concurrently cleaning and
The product of skin care effect.Skin is a vitals of human body, and the health and fitness to human body play an important role.Just
Under normal physiological status, skin can produce some dirts, the mainly sebum of smegma to mix shape with the dust in air
Into dirt, the cell debris that comes off of the dried residuals of skin sweat, keratoderma etc..These dirts on skin
If cleaning can block sebaceous glands Sweat glands channel not in time, cutaneous eubolism accelerates skin aging.Other skin
On dirt be microbial reproduction good environment, easily cause various dermopathic generations, so the skin of human body particularly face
The skin in portion needs periodically to be cleaned, to keep skin health.Conventional cleaning products cannot be in cleaning dynamics and dimension at present
Hold and balance is kept between skin normal secretions, it will usually remove excessive grease, have impact on skin normal secretions sebum, with this
It is easily tight after cleaning products cleaning skin, and it has been easily destroyed the balance of the microenvironment of skin surface.
The mildy wash with deep clean in the market is the narrow mouth of pipe packaging of round bottom lid body wide, undeniable
It is that the product of this kind of packaging has the advantages that popularization is simple, manufactures and designs maturation.But in this kind of face cleaning product to using latter stage
When, the lotion piled up near extra heavy pipe body cannot be extruded in tubule mouthful, and user has to throw away, and cause to waste.And this
The canned mildy wash of quasi-tradition, it is inconvenient to carry, take up room.
Regarding to the issue above, a kind of cosmetics of solid-state are occurred in that at present, which overcome traditional canned mildy wash inconvenient
The problem of carrying, but simultaneously, the cosmetics of this solid-state are difficult to dissolve, it is inconvenient when using.Thus, have recently emerged a kind of chance
The instant sheet mildy wash of water, it is typically made up of soluble carrier and active component, typically with starch or converted starch
As soluble carrier, then active component is mixed with starch, be beaten, paper processed obtains a kind of sheet with fixed specification and washes
Face milk, its small volume, is easy to carry, and chance water is instant when using, and receives pursuing for most consumers.
Such as in Chinese patent application CN105342877, inventor's starch has prepared a kind of ammonia with active component
Base acid cleaning tissue, amino acid cleansing paper cleaning face, is paper membrane piece film product due to making, small volume, and is solid, no
Excessive bottle Bottle ＆ Can tank is taken, portable, as long as being dissolved using with clear water, finished product energy 100% is biodegradable, environmental resource is not made
Into burden；The material of preparation is derived from natural safety, there is amino acid, fatty alcohol calcium, magnesium and sylvite etc. after water dissolves, rich in nutrition and
It is pure gentle non-stimulated to skin.But the amino acid cleansing paper there is a problem of as follows：One is with starch or converted starch conduct
Film forming agent, physical strength is inadequate, therefore, cleaning tissue easily splits in transportation, falls apart, and influences the use of product；Two are,
The universal retention rate in cleaning tissue of active component is relatively low, it is difficult to reaches the requirement of consumer, have impact on promoting the use of for product；
Three is that general converted starch can only dissolve in boiling water, it is impossible to directly dissolved in cold water, so causing the dissolving of cleaning tissue
Speed is slower, have impact on and uses, and is unfavorable for being lifted the experience of consumer.
Also fewer to the research of soluble cleaning tissue at present, the performance for how to lift cleaning tissue need scholars
Further experiment, therefore, easily fallen apart in transportation for existing soluble cleaning tissue；Active component retention rate it is low with
And dissolution velocity it is slower the problems such as, it is necessary to a kind of superior performance is provided, using effect it is good with deep layer cleaning effect can
Dissolubility cleaning tissue.
The content of the invention
In order to solve technical problem present in prior art, there is deep layer cleaning it is an object of the invention to provide one kind
Effect, its microenvironment that skin surface will not be destroyed while can carrying out deep clean to skin, this kind of cleaning tissue small volume,
It is convenient for carrying, it is easily wetted when water is contacted, and can quickly dissolve, and the retention rate of this kind of cleaning tissue active component is high.
The invention provides a kind of soluble cleaning tissue with deep layer cleaning effect, comprising：
A) 80~95% carrier components, the carrier components are included：
I) Soluble Anions starch, the content of the Soluble Anions starch be the carrier components weight 80~
90%；With
Ii) cation nanometer microcrystalline cellulose, the content of the cation nanometer microcrystalline cellulose is the carrier components
The 10~20% of weight；
B) 5~20% active component, the active component is included：Cellobiose dehydrogenase 0.5~2%, hyaluronic acid
0.5~2.5%, allantoin 0.5~2.5%, Sha of ancient India graceful 0.1~1%, xanthans 2~6%, Phenoxyethanol 0.05~0.5%,
Amino acid 0.5~1%, chicory inulin hydrolysate 2~5% and water 85~90%.
Soluble Anions starch herein is obtained by the way that pea starch is modified, compared with common starch,
The cleaning tissue prepared using Soluble Anions starch described herein, can be molten when water is contacted except itself will not be bonded
Solution is outer, it is surprisingly found by the inventors that, the flexible increase of its cleaning tissue for preparing treatment, and compared to common starch for, after
Phase more easy-formation.But similarly physical property is poor for the cleaning tissue that Soluble Anions starch is prepared, in transportation
Easily fall apart.Inventor attempts addition microcrystalline cellulose and usually carries out reinforcement, and effect is barely satisfactory, although because microcrystalline cellulose energy
The physical strength of soluble cleaning tissue is improved to a certain extent, but can reduce retention rate of the active ingredient in cleaning tissue, two
Person is difficult to obtain balance.And inventor find, microcrystalline cellulose is carried out it is cation-modified, be particularly well-suited to make the present invention can
Dissolubility cleaning tissue.Cation nanometer microcrystalline cellulose described herein can be tieed up while improving the physical strength of soluble cleaning tissue
Retention rate of the active ingredient in cleaning tissue is held, and unexpectedly, due to the huge specific surface of cation nanometer microcrystalline cellulose
The presence of product and positive surface charge, makes it possess excellent absorption property, and it can effectively adsorb and remove skin of face pore
The dead skin of depths, dirt and excessive sebum, so as to reach effect of deep layer cleaning.Risen for cation nanometer microcrystalline cellulose
To the mechanism of maintenance active component retention rate in cleaning tissue fail to understand that inventor thinks to be probably and cation nanometer crystallite is fine
A large amount of positive charges that the plain surface of dimension is present are relevant, the effect for making it possess retention.
Further, Soluble Anions starch described herein is obtained by following steps：
S1) digest：Pea starch is taken, a certain amount of citrate-phosphate disodium hydrogen cushioning liquid (pH7.0) is added, in boiling
Stirred in water bath is gelatinized, and takes out, and constant volume is configured to the gelatinization of starch solution of 12~20mg/ml, is shaken under 45~60 DEG C of waters bath with thermostatic control
5~10min is swung, AMS is added, 60~90min is digested, terminating reaction obtains starch enzymolysis liquid, standby；
S2) it is crosslinked：Soybean oil, sodium hydroxide solution, Arlacel-80 and epoxychloropropane are added toward above-mentioned starch enzymolysis liquid,
Stirring mixing, wherein, the weight ratio of soybean oil, sodium hydroxide solution, Arlacel-80 and epoxychloropropane is 1:(1~2):(0.1
~0.5):(0.2~0.8)；
S3) anionic：By ethanol solution, monochloroacetic acid, sodium hydroxide solution and after above-mentioned S2 step process
Starch enzymolysis liquid is separately added into reactor, is sufficiently stirred for, and is warming up to 50~80 DEG C, and glacial acetic acid is added after 12~24h of reaction, is adjusted
Section pH is 6.5~7.0, and filtering is washed with ethanol solution, is dried, and obtains anionic starch；
S4) it is modified：0.5~1g lysines, 0.5~1g carbonyl dimidazoles are added to the dimethylformamide of 42~60ml
In solution, 1~3h of normal-temperature reaction adds the anionic starch obtained by 2~5g above-mentioned steps S3, stirs, it is warming up to 55~
70 DEG C, 12~24h is reacted, washed and dried with ethanol after stratification, obtained final product.
Further, inventor has found to be particularly well-suited to system when the content of amylose in pea starch is 35.06%
Standby solubility cleaning tissue, it is functionally better than general pea starch.
Further, cation nanometer microcrystalline cellulose described herein is obtained by following steps：
Take microcrystalline cellulose routine techniques and nano micro crystal cellulose is obtained, nano micro crystal cellulose addition phosphate is delayed
Rush solution and obtain the nano micro crystal cellulose suspension that mass concentration is 3~8%, add NaOH molten toward above-mentioned suspension
Liquid, stirring 30~75min after add carboxymethyl chitosan, after 100~120 DEG C of 3~7h of stirring reaction, be directly cooled to 30 DEG C with
Lower terminating reaction, centrifugation, washing, pH is to 6.0~7.0 for regulation, is put into bag filter, with deionized water 7~12d of dialysis, ultrasound
Concussion 25~50min for the treatment of, obtains cation nanometer microcrystalline cellulose.
Further, the molecular weight of carboxymethyl chitosan described herein is 2~4 × 103, substitution value is 80~90%.
Further, the molecular weight of carboxymethyl chitosan described herein is 3 × 103, substitution value is 85%.
Further, active component described herein is included：Cellobiose dehydrogenase 1.5%, hyaluronic acid 1.5%, allantois
Element 2%, Sha of ancient India graceful 0.5%, xanthans 2.5%, Phenoxyethanol 0.2%, lysine 0.8%, chicory inulin hydrolysate 3% and
Water 88%.
Cellobiose dehydrogenase can promote the dissolving of soluble cleaning tissue, and it is to temperature and PH stabilizations, it is adaptable to make
Standby solubility cleaning tissue.Hyaluronic acid is widely present in human body and animal tissue cell gap, viscous with strong absorptive, height
The characteristics such as degree, macromolecular, are used for cosmetic high NMFs generally acknowledged in the world.Hyaluronic acid is acted on and skin table
Face, can form the viscous dance films of one layer of ventilative aquation in skin surface, increase the lubricious sense of skin, keep skin it is smooth, moist,
High resilience.Even if when external environment condition humidity changes, its moisture retention can adjust the moisture of skin to appropriateness all the time.
It is a kind of cyclic lipopeptide biosurfactant that Buddhist Sha is graceful, and molecular formula is C53H93N7O13, it can promote each effective
Composition is fitted with skin, promotes absorption of the skin to active component；Chicory inulin hydrolysate rich in various monose and nutrition into
Point, after cleaning skin, sufficient nutrition can be provided to skin, face can be made not tight after cleaning.
Further, chicory inulin hydrolysate described herein is obtained by following steps：
Weigh cichory root meal, add the purified water of 1~3 times of meal weight, 65~90 DEG C extract 1~3 time, every time 2~
3h, filtering merges leaching liquor, and it is the medicinal extract of 1.10-1.20, powder leaching liquor to be concentrated under reduced pressure under the conditions of 60 DEG C and surveys relative density
Broken, spray drying obtains witloof polysaccharide；The hydrochloric acid solution of above-mentioned witloof polysaccharide addition 3~6% is taken by 1:The ratio of (1~2) is mixed
Close, stir to obtain starch-polysaccharides solution, above-mentioned starch-polysaccharides solution is placed in 1~3h of reaction in 30~50 DEG C of water bath with thermostatic control, instead
Persistently stirred during answering, mixing speed is 1000~2500rpm, is obtained final product.
Further, amino acid described herein is selected from the one kind in glycine, lysine, histidine and arginine.
Correspondingly, a kind of side for preparing the above-mentioned soluble cleaning tissue with deep layer cleaning effect is also provided herein
Method, comprises the following steps：
A graceful Buddhist Sha, amino acid and chicory inulin hydrolysate) are taken, purified water is added, is mixed, be allowed to dissolve, must mixed
Thing；The mixing of xanthans, Phenoxyethanol, hyaluronic acid, allantoin and cellobiose dehydrogenase is taken, stirring is added to after being allowed to dissolving
In said mixture, triethanolamine is added, regulation pH is 5.0~7.0, obtains active component；
B) toward carrier components are added in the active component, high-speed stirred obtains mixed serum, and the mixed serum is moved into
In paper web, regulation reaction temperature is 40~60 DEG C, and rotating paper web makes moisture evaporation completely, and coil paper is cut, and punch forming is obtained final product.
Compared with prior art, cleaning tissue of the present invention has the advantage that：
1) the invention provides a kind of soluble cleaning tissue, it is prepared from by natural material, small volume, and thickness is only
0.2~0.3mm, is easy to carry, and being dissolved with clear water when using just can be so that dissolution velocity is fast, and cleaning effect is good, face after cleaning
It is not tight, have broad application prospects.
2) cationic nano micro crystal cellulose of the present invention, can not only improve the physical strength of soluble cleaning tissue, make
It is difficult to fall apart in transportation, improve the experience of consumer, additionally it is possible to maintain active ingredient in cleaning tissue
Retention rate, and the cleaning intensity of soluble cleaning tissue can be lifted；In addition, cellobiose takes off in present invention solubility cleaning tissue
Hydrogen enzyme can improve the dissolution velocity of soluble cleaning tissue, and the skin that chicory inulin hydrolysate can be given after cleaning provides sufficient
Nutrition, without tight feeling after cleaning skin.
Specific embodiment：
Below by way of the description of specific embodiment, the invention will be further described, but this is not to limit of the invention
System, those skilled in the art's basic thought of the invention, various modifications may be made or improves, but without departing from this
The basic thought of invention, within the scope of the present invention.
Pea starch of the present invention is purchased from the standing grain bio tech ltd of Lanzhou hundred, CAS 9005-25-8；Microcrystalline cellulose
Purchased from Henan An Rui bio tech ltd, CAS 9004-34-6；Carboxymethyl chitosan wins biotechnology purchased from Qingdao Shun
Co., Ltd of research institute, CAS 9012-76-4.
The preparation of embodiment 1, Soluble Anions starch of the present invention
S1) digest：Pea starch is taken, 5% citrate-phosphate disodium hydrogen cushioning liquid (pH7.0) is added, in boiling water bath
Middle stirring gelatinization, takes out, and constant volume is configured to the gelatinization of starch solution of 12~20mg/ml, 8min is vibrated under 50 DEG C of waters bath with thermostatic control,
AMS is added, 60min is digested, terminating reaction obtains starch enzymolysis liquid, standby；
S2) it is crosslinked：Soybean oil, sodium hydroxide solution, Arlacel-80 and epoxychloropropane are added toward above-mentioned starch enzymolysis liquid,
Stirring mixing, wherein, the weight ratio of soybean oil, sodium hydroxide solution, Arlacel-80 and epoxychloropropane is 1:1:0.2:0.5；
S3) anionic：By ethanol solution, monochloroacetic acid, sodium hydroxide solution and after above-mentioned S2 step process
Starch enzymolysis liquid is separately added into reactor, is sufficiently stirred for, and is warming up to 60 DEG C, and glacial acetic acid is added after reaction 24h, and adjusting pH is
6.5, filtering is washed with ethanol solution, is dried, and obtains anionic starch；
S4) it is modified：0.5 lysine, 0.5 carbonyl dimidazoles are added in the dimethyl formamide solution of 50ml, normal temperature
Reaction 2h, adds the anionic starch obtained by 3g above-mentioned steps S3, stirs, and is warming up to 60 DEG C, reacts 12h, stratification
Washed with ethanol and dried afterwards, obtained final product.
The preparation of embodiment 2, cation nanometer microcrystalline cellulose of the present invention
Microcrystalline cellulose is taken, is smashed, cross 20 mesh sieves, the hydrochloric acid 150ml of 45wt% is added under the conditions of 45 DEG C, stirred, instead
40min is answered, adds 9 times of deionized water dilution terminating reactions of volume, products therefrom deionized water to be centrifuged repeatedly flushing to pH
Value 5.0；The product that will be obtained is put into bag filter, with the constant pH value of deionized water dialyzing paper of flowing, by dialysis after it is outstanding
Supernatant liquid processes 10min with ultrasonic oscillator, obtains nano micro crystal cellulose suspension, and to avoid product because of heat accumulation, treatment exists
Carried out in hot bath；
PBS is added to obtain the nano microcrystalline that mass concentration is 5% toward above-mentioned nano micro crystal cellulose suspension
Cellulose suspension, sodium hydroxide solution is added toward above-mentioned suspension, and carboxymethyl chitosan, 100 DEG C are added after stirring 65min
After stirring reaction 5h, less than 30 DEG C terminating reactions are directly cooled to, be centrifuged, washing, pH is to 6.5 for regulation, is put into bag filter, uses
Deionized water dialysis 8d, ultrasonic vibration treatment 40min, obtains cation nanometer microcrystalline cellulose, wherein, the carboxymethyl chitosan
Molecular weight be 3 × 103, substitution value is 85%.
The preparation of embodiment 3, chicory inulin hydrolysate of the present invention
Cichory root meal is weighed, the purified water of 2 times of meal weight is added, 80 DEG C extract 2 times, each 2h, filtering merges leaching
Extract, leaching liquor is concentrated under reduced pressure under the conditions of 60 DEG C the medicinal extract for surveying that relative density is 1.15, is crushed, and spray drying obtains witloof
Polysaccharide；The hydrochloric acid solution of above-mentioned witloof polysaccharide addition 5% is taken by 1:1 ratio mixing, stirs to obtain starch-polysaccharides solution, will be above-mentioned
Starch-polysaccharides solution is placed in 40 DEG C of water bath with thermostatic control and reacts 2h, is persistently stirred in course of reaction, and mixing speed is 2000rpm,
Obtain final product.
Embodiment 4, present invention solubility cleaning tissue
Soluble cleaning tissue is made up of following preparing raw material described in the embodiment of the present invention 4：
85% carrier components and 15% active component：
The carrier components Soluble Anions starch and sun described in 15% embodiment 2 as described in 85% embodiment 1
Ion nano micro crystal cellulose is constituted；
The active component is consisted of the following composition：Cellobiose dehydrogenase 1.5%, hyaluronic acid 1.5%, allantoin
2%th, Sha of ancient India graceful 0.5%, xanthans 2.5%, Phenoxyethanol 0.2%, lysine 0.8%, chicory inulin hydrolysis described in embodiment 3
Thing 3% and water 88%.
Preparation method：
A graceful Buddhist Sha, amino acid and chicory inulin hydrolysate) are taken, purified water is added, is mixed, be allowed to dissolve, must mixed
Thing；The mixing of xanthans, Phenoxyethanol, hyaluronic acid, allantoin and cellobiose dehydrogenase is taken, stirring is added to after being allowed to dissolving
In said mixture, triethanolamine is added, regulation pH is 6.0, obtains active component；
B) toward carrier components are added in the active component, high-speed stirred obtains mixed serum, and the mixed serum is moved into
In paper web, regulation reaction temperature is 50 DEG C, and rotating paper web makes moisture evaporation completely, and coil paper is cut, and punch forming is obtained final product.
Embodiment 5, present invention solubility cleaning tissue
Soluble cleaning tissue is made up of following preparing raw material described in the embodiment of the present invention 5：
80% carrier components and 10% active component：
The carrier components Soluble Anions starch and sun described in 20% embodiment 2 as described in 80% embodiment 1
Ion nano micro crystal cellulose is constituted；
The active component is consisted of the following composition：Cellobiose dehydrogenase 0.5%, hyaluronic acid 1%, allantoin
1.5%th, Sha of ancient India graceful 0.5%, xanthans 2.5%, Phenoxyethanol 0.2%, glycine 0.8%, chicory inulin water described in embodiment 3
Solution thing 2% and water 91%.
Preparation method such as embodiment 4.
Embodiment 6, present invention solubility cleaning tissue
Soluble cleaning tissue is made up of following preparing raw material described in the embodiment of the present invention 6：
95% carrier components and 5% active component：
The carrier components Soluble Anions starch and sun described in 10% embodiment 2 as described in 90% embodiment 1
Ion nano micro crystal cellulose is constituted；
The active component is consisted of the following composition：Cellobiose dehydrogenase 2%, hyaluronic acid 2.5%, allantoin
2.0%th, Sha of ancient India graceful 1%, xanthans 6%, Phenoxyethanol 0.5%, arginine 1%, chicory inulin hydrolysate described in embodiment 3
5% and water 80%.
Preparation method such as embodiment 4.
Comparative example 1, soluble cleaning tissue
Comparative example 1 is with the difference of embodiment 4：The carrier components be Soluble Anions starch, remaining parameter with
Operation such as embodiment 4.
Comparative example 2, soluble cleaning tissue
Comparative example 2 is with the difference of embodiment 4：Carrier components Soluble Anions as described in 85% embodiment 1
Starch and 15% microcrystalline cellulose composition, remaining parameter and operation such as embodiment 4.
Comparative example 3, soluble cleaning tissue
Comparative example 3 is with the difference of embodiment 4：Cellobiose dehydrogenase, remaining parameter and behaviour are replaced with AMS
Make such as embodiment 4.
Comparative example 4, soluble cleaning tissue
Comparative example 4 is with the difference of embodiment 4：Remove chicory inulin hydrolysate, remaining parameter is with operation such as embodiment
4。
Test example one, quality evaluation
Soluble cleaning tissue described in the embodiment of the present invention 4~6 and comparative example 1~3 is taken, quality test is carried out to it, surveyed
Test result is as shown in table 1.
The test result of table 1
As shown in Table 1, the soluble cleaning tissue average thickness of the embodiment of the present invention 4~6 is between 0.2~0.3mm, and physics is strong
Degree meets the requirements, and is difficult to fall apart, and dissolution velocity is fast, most short only to need 45s and be completely dissolved and effective in soluble cleaning tissue
The retention rate of composition is high, reaches more than 80%, wherein, got over soluble cleaning tissue best performance described in embodiment 4, it is the present invention
Most preferred embodiment.
Compared with soluble cleaning tissue described in embodiment 4, dissolution velocity has lifting to soluble cleaning tissue described in comparative example 1,
It is unobvious, but physical strength has substantially reduction, is extremely easily fallen apart in transportation, and active ingredient retention rate has significantly
Decline, this explanation adds cation nanometer microcrystalline cellulose to improve the physical strength of soluble cleaning tissue, moreover it is possible to carry
The retention rate of active ingredient high.
Can be seen that replacing cation nanometer microcrystalline cellulose to be unfavorable for microcrystalline cellulose can from the result of the test of comparative example 2
The lifting of dissolubility face cleaning paper quality, compared with Example 4, its dissolution velocity have substantially reduction, and active ingredient retention rate only
Only 68.8%, 16.5% is reduced compared with Example 4.
Compared with Example 4, the dissolution velocity of soluble cleaning tissue is decreased obviously described in comparative example 3, reduces 60%,
And active ingredient retention rate has reduction, but amplitude is little.This explanation, the presence of cellobiose dehydrogenase can improve soluble face cleaning
The dissolution velocity of paper.
Test example two, the experiment of human body skin cleaning effect
2.1 test population：Average age is the student enrollment 350 of 23 years old, is randomly divided into 7 groups, every group 50, its
In, male 138, women 212, skin health not damaged.
2.2 method of testing：It is test sample to take soluble cleaning tissue described in the embodiment of the present invention 4~6 and comparative example 1~4
Product, selection subject forehead, cheek, nose both sides, 4 positions of chin are experiment position, and skin oil and fat water is used by technical staff
Fat content before dividing alkalinity acidity tester (German CK electronics corporations) determination test position to smear cosmetics, every is surveyed 5 times, is taken
Average value.Subject tests the above-mentioned sample cleanup in position at 4, and is control with corresponding blank test position, and examination is not smeared
Sample, is cleaned with clear water.During experiment, subject can not smear any other cosmetics at experiment position.Each subject is smearing
After sample, oil stain removing rate is determined using skin oil and fat moisture alkalinity acidity tester (German CK electronics corporations), count subject
The numerical value that experiment position measures every time, analyzing skin oil stain removing rate determines sample cleanup effect.
2.3 standards of grading:
Cure：Skin excess oil removes clean, disappearance；
It is effective：Skin oil and fat is bright to see decrease；
Effectively：Skin oil and fat has reduction in various degree；
It is invalid：Skin oil and fat sign without any improvement.
2.4 results are as shown in table 2.
| Group | Number of cases | Cure (rate) | Effective (rate) | Effectively (rate) | Invalid (rate) | Total effective rate |
| Embodiment 4 | 50 | 36 (72%) | 12 (24%) | 2 (4%) | 0 | 100% |
| Embodiment 5 | 50 | 36 (72%) | 8 (16%) | 5 (10%) | 1 (2%) | 98% |
| Embodiment 6 | 50 | 35 (70%) | 10 (20%) | 4 (8%) | 1 (2%) | 98% |
| Comparative example 1 | 50 | 28 (56%) | 3 (6%) | 6 (12%) | 13 (26%) | 74% |
| Comparative example 2 | 50 | 25 (50%) | 8 (16%) | 7 (14%) | 10 (20%) | 80% |
| Comparative example 3 | 50 | 33 (66%) | 8 (16%) | 2 (4%) | 7 (14%) | 86% |
| Comparative example 4 | 50 | 30 (60%) | 4 (8%) | 4 (8%) | 12 (24%) | 76% |
As shown in Table 2, soluble cleaning tissue has excellent cleaning efficacy described in the embodiment of the present invention 4~6, and after use
It is not tight.Compared with Example 4, the cleaning effect of soluble cleaning tissue is decreased obviously described in comparative example 1~4, especially right
Ratio 1 and comparative example 4, respectively 74% and 76%, wherein, by the effect assessment after to use, 96% subject is anti-
There is tight feeling in face after reflecting with soluble cleaning tissue cleaning described in comparative example 4, and this explanation addition chicory inulin hydrolysate can be solved
The tight problem of face after certainly cleaning.
Claims (10)
1. a kind of soluble cleaning tissue with deep layer cleaning effect, it is characterised in that include：
A) 80~95% carrier components, the carrier components are included：
I) Soluble Anions starch, the content of the Soluble Anions starch be the carrier components weight 80~
90%；With
Ii) cation nanometer microcrystalline cellulose, the content of the cation nanometer microcrystalline cellulose is the carrier components weight
10%~20%；
B) 5~20% active component, the active component is included：Cellobiose dehydrogenase 0.5~2%, hyaluronic acid 0.5~
2.5%th, allantoin 0.5~2.5%, Sha of ancient India graceful 0.1~1%, xanthans 2~6%, Phenoxyethanol 0.05~0.5%, amino acid
0.5~1%, chicory inulin hydrolysate 2~5% and water 85~90%.
2. there is the soluble cleaning tissue of deep layer cleaning effect as claimed in claim 1, it is characterised in that described soluble cloudy
Ionic starch is obtained by following steps：
S1) digest：Pea starch is taken, a certain amount of citrate-phosphate disodium hydrogen cushioning liquid (pH7.0) is added, in boiling water bath
Middle stirring gelatinization, takes out, and constant volume is configured to the gelatinization of starch solution of 12~20mg/ml, 5 are vibrated under 45~60 DEG C of waters bath with thermostatic control
~10min, adds AMS, digests 60~90min, and terminating reaction obtains starch enzymolysis liquid, standby；
S2) it is crosslinked：Soybean oil, sodium hydroxide solution, Arlacel-80 and epoxychloropropane, stirring are added toward above-mentioned starch enzymolysis liquid
Mixing, wherein, the weight ratio of soybean oil, sodium hydroxide solution, Arlacel-80 and epoxychloropropane is 1:(1~2):(0.1~
0.5):(0.2~0.8)；
S3) anionic：By ethanol solution, monochloroacetic acid, sodium hydroxide solution and through the starch after above-mentioned S2 step process
Enzymolysis liquid is separately added into reactor, is sufficiently stirred for, and is warming up to 50~80 DEG C, and glacial acetic acid is added after 12~24h of reaction, adjusts pH
It is 6.5~7.0, filtering is washed with ethanol solution, is dried, and obtains anionic starch；
S4) it is modified：0.5~1g lysines, 0.5~1g carbonyl dimidazoles are added to the dimethyl formamide solution of 42~60ml
In, 1~3h of normal-temperature reaction adds the anionic starch obtained by 2~5g above-mentioned steps S3, stirs, and is warming up to 55~70 DEG C,
12~24h of reaction, is washed and is dried after stratification with ethanol, is obtained final product.
3. there is the soluble cleaning tissue of deep layer cleaning effect as claimed in claim 2, it is characterised in that the pea starch
The content of middle amylose be 35.06%.
4. there is the soluble cleaning tissue of deep layer cleaning effect as claimed in claim 1, it is characterised in that the cation is received
Rice microcrystalline cellulose is obtained by following steps：
Take microcrystalline cellulose routine techniques and nano micro crystal cellulose is obtained, add phosphate-buffered molten nano micro crystal cellulose
Liquid obtains the nano micro crystal cellulose suspension that mass concentration is 3~8%, and sodium hydroxide solution is added toward above-mentioned suspension, stirs
Carboxymethyl chitosan is added after mixing 30~75min, after 100~120 DEG C of 3~7h of stirring reaction, less than 30 DEG C is directly cooled to eventually
Only react, be centrifuged, washing, pH is to 6.0~7.0 for regulation, is put into bag filter, with deionized water 7~12d of dialysis, ultrasonic vibration
25~50min for the treatment of, obtains cation nanometer microcrystalline cellulose.
5. there is the soluble cleaning tissue of deep layer cleaning effect as claimed in claim 4, it is characterised in that the carboxymethyl shell
The molecular weight of glycan is 2~4 × 103, substitution value is 80~90%.
6. there is the soluble cleaning tissue of deep layer cleaning effect as claimed in claim 5, it is characterised in that the carboxymethyl shell
The molecular weight of glycan is 3 × 103, substitution value is 85%.
7. there is the soluble cleaning tissue of deep layer cleaning effect as claimed in claim 1, it is characterised in that the active component
Comprising：Cellobiose dehydrogenase 1.5%, hyaluronic acid 1.5%, allantoin 2%, Sha of ancient India graceful 0.5%, xanthans 2.5%, benzene oxygen
Ethanol 0.2%, lysine 0.8%, chicory inulin hydrolysate 3% and water 88%.
8. the soluble cleaning tissue with deep layer cleaning effect as described in claim 1 or 7, it is characterised in that the witloof
Synanthrin hydrolysate is obtained by following steps：
Weigh cichory root meal, add the purified water of 1~3 times of meal weight, 65~90 DEG C extract 1~3 time, every time 2~3h, mistake
Filter, merges leaching liquor, and it is the medicinal extract of 1.10-1.20 leaching liquor to be concentrated under reduced pressure under the conditions of 60 DEG C and surveys relative density, is crushed, spray
Mist is dried, and obtains witloof polysaccharide；The hydrochloric acid solution of above-mentioned witloof polysaccharide addition 3~6% is taken by 1:The ratio mixing of (1~2), stirring
Starch-polysaccharides solution is obtained, above-mentioned starch-polysaccharides solution 1~3h of reaction in 30~50 DEG C of water bath with thermostatic control is placed in, in course of reaction
Lasting stirring, mixing speed is 1000~2500rpm, is obtained final product.
9. the soluble cleaning tissue with deep layer cleaning effect as described in claim 1 or 7, it is characterised in that the amino
Acid is selected from the one kind in glycine, lysine, histidine and arginine.
10. a kind of method of the soluble cleaning tissue with deep layer cleaning effect prepared as described in claim 1~9 is any,
It is characterised in that it includes following steps：
A graceful Buddhist Sha, amino acid and chicory inulin hydrolysate) are taken, purified water is added, is mixed, be allowed to dissolve, obtain mixture；
The mixing of xanthans, Phenoxyethanol, hyaluronic acid, allantoin and cellobiose dehydrogenase is taken, stirring is added to after being allowed to dissolving
State in mixture, add triethanolamine, regulation pH is 5.0~7.0, obtains active component；
B) toward carrier components are added in the active component, high-speed stirred obtains mixed serum, and the mixed serum is moved into paper web
Interior, regulation reaction temperature is 40~60 DEG C, and rotating paper web makes moisture evaporation completely, and coil paper is cut, and punch forming is obtained final product.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107156519A (en) * | 2017-06-12 | 2017-09-15 | 广东康达尔农牧科技有限公司 | A kind of feed addictive of effective regulation chicken intestinal health and preparation method thereof |
| CN108125857A (en) * | 2018-01-10 | 2018-06-08 | 威莱(广州)日用品有限公司 | A kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof |
| CN108354857A (en) * | 2018-04-08 | 2018-08-03 | 大连军门保健食品有限公司 | Water beautifying liquid and preparation method thereof is refined after a kind of extraction of witloof polysaccharide |
| TWI647357B (en) * | 2017-06-08 | 2019-01-11 | 十藝生技股份有限公司 | Cleansing paper formula with natural plant source and preparation method thereof |
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| CN101868479A (en) * | 2007-11-20 | 2010-10-20 | 罗盖特公司 | Aqueous composition containing at least one soluble gelatinized anionic starch |
| CN102080346A (en) * | 2010-11-25 | 2011-06-01 | 山东轻工业学院 | Application of cation nano microcrystalline cellulose as paper reinforcing agent |
| CN105342877A (en) * | 2015-11-24 | 2016-02-24 | 梁修剑 | Preparation formula and preparation method for amino acid face-cleansing paper |
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| CN101868479A (en) * | 2007-11-20 | 2010-10-20 | 罗盖特公司 | Aqueous composition containing at least one soluble gelatinized anionic starch |
| CN102080346A (en) * | 2010-11-25 | 2011-06-01 | 山东轻工业学院 | Application of cation nano microcrystalline cellulose as paper reinforcing agent |
| CN105342877A (en) * | 2015-11-24 | 2016-02-24 | 梁修剑 | Preparation formula and preparation method for amino acid face-cleansing paper |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI647357B (en) * | 2017-06-08 | 2019-01-11 | 十藝生技股份有限公司 | Cleansing paper formula with natural plant source and preparation method thereof |
| CN107156519A (en) * | 2017-06-12 | 2017-09-15 | 广东康达尔农牧科技有限公司 | A kind of feed addictive of effective regulation chicken intestinal health and preparation method thereof |
| CN108125857A (en) * | 2018-01-10 | 2018-06-08 | 威莱(广州)日用品有限公司 | A kind of novel quick defoaming bacteriostatic hand sanitizer and preparation method thereof |
| CN108354857A (en) * | 2018-04-08 | 2018-08-03 | 大连军门保健食品有限公司 | Water beautifying liquid and preparation method thereof is refined after a kind of extraction of witloof polysaccharide |
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| CN106667795B (en) | 2018-05-08 |
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Effective date of registration: 20180524 Address after: 511356 59 Hefeng Road, Yonghe Economic Zone, Guangzhou economic and Technological Development Zone, Guangdong Patentee after: Guangzhou Tong Kang Bio Technology Co., Ltd. Address before: 510530 No. 84, he he road, Guangzhou high tech Industrial Development Zone, Guangdong Patentee before: Zou Weiquan |