CN103565699A - Lycium ruthenicum mill freckle-removing and whitening anti-aging essence and preparation method of essence - Google Patents
Lycium ruthenicum mill freckle-removing and whitening anti-aging essence and preparation method of essence Download PDFInfo
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- CN103565699A CN103565699A CN201310557661.XA CN201310557661A CN103565699A CN 103565699 A CN103565699 A CN 103565699A CN 201310557661 A CN201310557661 A CN 201310557661A CN 103565699 A CN103565699 A CN 103565699A
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- fructus lycii
- black fructus
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- whitening
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Landscapes
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Abstract
The invention provides a lycium ruthenicum mill freckle-removing and whitening anti-aging essence. According to the lycium ruthenicum mill freckle-removing and whitening anti-aging essence, natural biological extracts are selected as active ingredients, especially the essence gives full play to the nutrition effect of lycium ruthenicum mill, can inhibit the generation of oxygen radical, obstructs the stimulation of ultraviolet rays so as to prevent the formation of melanin, and fundamentally avoids the formation of spots, so that the spots can be thoroughly removed, the skin is whitened and the senility is prevented; furthermore, the lycium ruthenicum mill freckle-removing and whitening anti-aging essence has very strong effects of moisturizing and replenishing water, can be used for moistening and nourishing the skin so as to enable the skin to be restored to be elastic and glossy, and is mild without stimulation, free from side effects and remarkable in effect; after being used for a long time, the lycium ruthenicum mill freckle-removing and whitening anti-aging essence can maintain the skin to be in a young state; the anti-aging essence is simple in technology and low in cost.
Description
Technical field
The present invention relates to a kind of black Fructus Lycii freckle removing and whitening defying age essence and preparation method thereof.
Background technology
Skin is the barrier of human body, is the real picture of health.Impact due to factors such as internal organs function, endocrine, heredity, medicine, ultraviolet radiation, stress, traumatic, malnutrition, cosmetics inferior, as the antioxidant system activity decreased of body self and immunity degradation, human body skin are exposed to the medium-term and long-term reasons such as ultraviolet radiation, atmospheric pollution that are subject to of external environment condition, in body, oxygen-derived free radicals increases, tryrosinase increases and active increasing, will produce mottle, pigmentation, xerosis cutis is wrinkling, face is tarnished, the state in subhealth state.
Melanin has protective effect to skin, and after ultraviolet radiation, to deepen be the physiological protective reaction of human normal to the colour of skin, because dark color can stop ultraviolet penetration, collagen protein and the elastic fibers of protection skin corium are not destroyed, and avoid skin burn.Therefore it is necessary, in skin, containing a certain amount of melanocyte.Melanic forming process is: the tyrosine being present in melanocyte tissue is progressively converted to eumelanin through intermediate such as DOPA, DOPA quinone, dopachrome, dihydroxy indoles under the effect of the enzymes such as tryrosinase.And then melanocyte tissue in stratum basale cell, is brought to melanin transfer in horny layer along with the metabolism of cell, finally come off with keratinocyte.When excessive synthetic melanin remains in skin and is not discharged into skin when outside, can there is pigmentation and produce mottle, accelerate skin aging.When the activity of tryrosinase is suppressed when synthetic with anti-melanin, can reach the effect of freckle removing and whitening, and suppress dopachrome interconvertible enzyme, DHICA enzyme also can reduce melanic generation.
But, now commercially available whitening, speckle removing, antisenescence product is a feast for the eyes, but the lead in most products, hydrargyrum, phenol content exceed standard, although in a short time can whitening and speckle dispelling, but life-time service can make keratodermatitis attenuation come off, cause skin resistance to decline, form new more mottle, be unfavorable for further skin protection.
Summary of the invention
The object of the present invention is to provide a kind of freckle removing and whitening defying age essence that natural biological extract is active component and preparation method thereof of take.
The invention provides a kind of black Fructus Lycii freckle removing and whitening defying age essence, it is that raw material by following percentage by weight is prepared from:
Wherein, described black Fructus Lycii fruit powder extracting solution is the water extract of black Fructus Lycii fruit powder; Preferably, the preparation method of black Fructus Lycii extracting solution is as follows: precision takes the dried powder of 5g black Fructus Lycii, add 50mL deionized-distilled water, in 50 ℃ of water-baths, extract 2 times, each 15 minutes, after filtration, residue is added to water 100mL extracts 2 times at 75 ℃, each 15 minutes, merge extracted twice liquid, filter, be evaporated to 10g/mL, obtain black Fructus Lycii extracting solution.
Wherein, Aloe extraction solution preparation method is as follows: get the clean aloe leaf chopping that 200g is fresh, after grinding 0.5h, put into iodine flask, add 100mL soak with ethanol 5h to decolour, sucking filtration (recovery ether), adds 300mL volume fraction and is distilling under reduced pressure after 95% soak with ethanol 24h, and residual ether and excessive ethanol low temperature are steamed, be concentrated into 10g/mL, obtain Aloe extraction solution.
Wherein, the preparation method of seaweed extracted liquor is as follows: the Sargassum after the removal of impurity is cleaned with the dilute acid soln that pH is 2～4, rub, and grind homogenate in the dilute acid soln that is 2～4 at pH, then by the Sargassum after homogenate 121～135 ℃ of temperature, under pressure 1～5MPa, ripening sterilizing is 0.5～2 hour, Sargassum slurry after degraded adds alkali and adjusts pH to 5.0-7.0, to the cultured probiotic bacteria strain normal fermentation in advance of inoculation in the Sargassum serosity after adjusting, again to fermentation after serosity in add algin oligosaccharide to allocate, probiotic bacteria is protected, propagation, be deployed into the serosity that concentration is 20g/mL, be seaweed extracted liquor.
But the extracting method of various extracts is not limited to said method, the disclosed extracting method of manufacturing cosmetics-stage extract of all prior aries is all applicable to the present invention.
Wherein, described Carbopol 941 first adds water 80 ℃ of left and right stirring and dissolving by weight 1:100, is made into 1% colloidal solution standby.
Wherein, described solubilizing agent is selected from one or more in HPS, Cremophor RH40, PPG-1-PEG-9 Laurel glycol ethers, PEG-400 Polyethylene Glycol, polyoxyethylated coconut oil alcohol-7, Tween20.
Wherein, described antibacterial is selected from one or more in germall-BP, extremely U.S. No. II, Kazon, G-Plus.
Preferably, it is that raw material by following percentage by weight is prepared from:
In the present invention, multiple natural extract is used in combination, has brought into play more good skin care activity, for market provides a kind of skin effect better, safe skin care item.
The present invention also provides the preparation method of above-mentioned black Fructus Lycii freckle removing and whitening defying age essence, and it comprises the steps:
(1) Carbopol 941 is added to water stirring and dissolving at the temperature of 80 ℃ of left and right by weight 1:100, be made into 1% colloidal solution standby;
(2) hyaluronic acid, allantoin, glycerol, 1,3 butylene glycol, disodiumedetate, methyl hydroxybenzoate, solubilizing agent and water stirring and dissolving at 80～90 ℃ is abundant, form transparent solution;
(3) the Carbopol 941 solution that is 1% by (1) prepared concentration slowly joins in (2) solution, and adds triethanolamine, stirs while adding, and makes to dissolve mix homogeneously;
(4) when solution temperature is down to 40～50 ℃, add antibacterial, black Fructus Lycii extracting solution, Aloe extraction solution, seaweed extracted liquor, essence, stir, obtain black Fructus Lycii freckle removing and whitening defying age essence.
Wherein, black Fructus Lycii extracting solution is the water extract of black Fructus Lycii fruit powder.The composition such as rich in proteins, aminoacid, flavone, procyanidin, fat, polysaccharide, vitamin E in lycium ruthenicum fruit.Protein is the structural material of human body skin, gives skin with nutrition, can make impaired cell, tissue obtain timely high-quality repairing, makes the high resilience of skin gloss, delaying senility.In lycium ruthenicum fruit, contain 17 seed amino acids except tryptophan, aminoacid is form organism protein and with one of closely bound up base substance of vital movement, nutrition can be provided, promote growth, maintain normal metabolism.Assessment of Pigment of Lycium ruthenicum Murr is anthocyanin class and flavone compound, and its non-oxidizability is obviously better than than vitamin E, and visible ray and ultraviolet are had to Stabilization.The non-oxidizability of flavone is mainly manifested in aspects such as removing free radical and anti-peroxidation.
The aloin that Aloe extraction solution contains, Aloe resin B, have certain effect at aspect tools such as moisturizing, antiinflammatory, antibacterial, antipruritic, antiallergic, softening skin, anti-acne, antiperspirant deodorant, and ultraviolet is had to strong Absorption, prevents skin burn.The composition that Aloe contains multiple elimination superoxide radical, as superoxide dismutase, catalase, can make skin delicate, flexible, has the effects such as anticorrosion and slow down aging.Aloe glue is natural sun-prevention component, can effectively suppress the ultraviolet in daylight, prevents pigmentation, keeps whitening skin.
Seaweed extracted liquor is a kind of marine organisms product of pure natural, include abundant algin acid, crude protein, multivitamin, enzyme, trace element etc., these nutrients can reduce skin surface blood fat after skin absorbs, promote the hemopoietic function of epidermis cell, can produce bacteriostasis to cell in vitro, also there is moisturizing, smooth function.In addition, a large amount of aniones that contain, can stimulate fibrocyte to generate collagen protein and elastin laminin, promote the metabolism of skin, have given its crease-resistant, antidotal effect.
Black Fructus Lycii freckle removing and whitening defying age essence provided by the invention selects natural biological extract as active component, particularly given full play to the nutritive effect of black Fructus Lycii, can suppress the generation of oxygen-derived free radicals, intercepting ultraviolet stimulation melanin forms, fundamentally break off the formation of speckle, thereby thorough dispelling stain, whitening and softening skin, anti-aging in advance, but also there is very strong moisturizing, moisturizing effect, moisten nutrition skin, make skin recover elasticity and gloss, gentle non-stimulated, have no side effect, effect is remarkable, skin life-time service can keep young state state, processing technology is simple, cost is low.
Below pass through the specific embodiment; scope of the present invention is further elaborated and is illustrated; but protection scope of the present invention is not limited to this; any those of ordinary skill in the art are in the disclosed technical scope of the present invention; can be without modification or the replacement of creative work, within all should being encompassed in protection scope of the present invention.
The specific embodiment
Aloe extraction solution preparation method is as follows: get the clean aloe leaf chopping that 200g is fresh, after grinding 0.5h, put into iodine flask, add 100mL soak with ethanol 5h to decolour, sucking filtration (recovery ether), add 300mL volume fraction and be distilling under reduced pressure after 95% soak with ethanol 24h, residual ether and excessive ethanol low temperature are steamed, be concentrated into 10g/mL, obtain Aloe extraction solution.
The preparation method of seaweed extracted liquor is as follows: the Sargassum after the removal of impurity is cleaned with the dilute acid soln that pH is 2～4, rub, and grind homogenate in the dilute acid soln that is 2～4 at pH, then by the Sargassum after homogenate 121～135 ℃ of temperature, under pressure 1～5MPa, ripening sterilizing is 0.5～2 hour, Sargassum slurry after degraded adds alkali and adjusts pH to 5.0-7.0, to the cultured probiotic bacteria strain normal fermentation in advance of inoculation in the Sargassum serosity after adjusting, again to fermentation after serosity in add algin oligosaccharide to allocate, probiotic bacteria is protected, propagation, be deployed into the serosity that concentration is 20g/mL, be seaweed extracted liquor.
The black Fructus Lycii extracting solution that the present invention uses is the water extract of black Fructus Lycii fruit powder, its concrete preparation method can be: precision takes the dried powder of 5g black Fructus Lycii, add 50mL deionized-distilled water, in 50 ℃ of water-baths, extract 2 times, each 15 minutes, after filtration, residue is added to water 100mL extracts 2 times at 75 ℃, each 15 minutes, merge extracted twice liquid, filter, be evaporated to 10g/mL, obtain black Fructus Lycii extracting solution.
Concentration after concentrated in the present invention is all with the mass/volume of concentrated solution, to calculate the ratio of gained.
In the embodiment of the present invention, each component is listed in table 1, and proportional quantity is with mass percent example.
Table 1
The preparation method of the embodiment of the present invention is all according to following steps:
(1) Carbopol 941 is added to water stirring and dissolving at the temperature of 80 ℃ of left and right by weight 1:100, be made into 1% colloidal solution standby;
(2) hyaluronic acid, allantoin, glycerol, 1,3 butylene glycol, disodiumedetate, methyl hydroxybenzoate, solubilizing agent and water stirring and dissolving at 80～90 ℃ is abundant, form transparent solution;
(3) the Carbopol 941 solution that is 1% by (1) prepared concentration slowly joins in (2) solution, and adds triethanolamine, stirs while adding, and makes to dissolve mix homogeneously;
(4) when solution temperature is down to 40～50 ℃, add antibacterial, black Fructus Lycii extracting solution, Aloe extraction solution, seaweed extracted liquor, essence, stir, obtain black Fructus Lycii freckle removing and whitening defying age essence.
By effect comparison, the prescription best results of embodiment 3.
Embodiment 9
The embodiment of the present invention 3 Detection of Stability:
1, pH value is 6.9.
2, heat resistant test, puts into calorstat (40 ± 1) ℃ one bottle of sample of Packing Intact and keeps 24h, returns to after room temperature without oil-water separation phenomenon.
3, low temperature resistant test, puts into refrigerator-5～-10 ℃ one bottle of sample of Packing Intact and places 24h, returns to after room temperature without layering, coarse, metachromatism.
4, centrifugal test, places in centrifuge one bottle of sample of Packing Intact with 2000 revs/min, and centrifugal 30 minutes, without oil-water separation phenomenon.
As can be seen here, the essence of the embodiment of the present invention 3 preparations has good stability.
Embodiment 9 clinical experiment of the present invention and result
The whitening effect test of embodiment 1 and embodiment 3 prepared products:
Select healthy normal aspiration trier 40 people, be divided into 2 groups, every group of 20 people, and irradiate wrist inside region with UVA, make this part, region tanned;
The product A, the B that with embodiment 1 and embodiment 3, make respectively, smear to respectively 2 groups of triers, and one day twice, smear 30 days, be only applied in the one side of skin tanning at every turn.
Table 2
| ? | Effectively | Generally | Invalid | Effective percentage |
| A product | 12 | 6 | 2 | 60％ |
| B product | 17 | 3 | 0 | 85％ |
Test result: after 30 days, every group of trier be local to shine and be coated with the general all original whiter without the skin of smearing of product of the present invention in black region, and shine black region end, to smear skin of the present invention original more black without the skin of smearing.And after smearing, trier's mottle has the trend of desalination, smear place's skin exquisiteness glossy, high resilience.
Claims (9)
1. a black Fructus Lycii freckle removing and whitening defying age essence, is characterized in that: it is that raw material by following percentage by weight is prepared from:
2. black Fructus Lycii extracting solution according to claim 1, is characterized in that: described black Fructus Lycii extracting solution is the water extract of black Fructus Lycii fruit powder; Preferably, the preparation method of black Fructus Lycii extracting solution is as follows: precision takes the dried powder of 5g black Fructus Lycii, add 50mL deionized-distilled water, in 50 ℃ of water-baths, extract 2 times, each 15 minutes, after filtration, residue is added to water 100mL extracts 2 times at 75 ℃, each 15 minutes, merge extracted twice liquid, filter, be evaporated to 10g/mL, obtain black Fructus Lycii extracting solution.
3. Aloe extraction solution according to claim 1, it is characterized in that: Aloe extraction solution preparation method is as follows: get the clean aloe leaf chopping that 200g is fresh, after grinding 0.5h, put into iodine flask, add 100mL soak with ethanol 5h to decolour, sucking filtration (recovery ether), adds 300mL volume fraction and is distilling under reduced pressure after 95% soak with ethanol 24h, and residual ether and excessive ethanol low temperature are steamed, be concentrated into 10g/mL, obtain Aloe extraction solution.
4. seaweed extracted liquor according to claim 1, it is characterized in that: the preparation method of seaweed extracted liquor is as follows: the Sargassum after the removal of impurity is cleaned with the dilute acid soln that pH is 2～4, rub, and grind homogenate in the dilute acid soln that is 2～4 at pH, then by the Sargassum after homogenate 121～135 ℃ of temperature, under pressure 1～5MPa, ripening sterilizing is 0.5～2 hour, Sargassum slurry after degraded adds alkali and adjusts pH to 5.0-7.0, to the cultured probiotic bacteria strain normal fermentation in advance of inoculation in the Sargassum serosity after adjusting, again to fermentation after serosity in add algin oligosaccharide to allocate, probiotic bacteria is protected, propagation, be deployed into the serosity that concentration is 20g/mL, be seaweed extracted liquor.
5. black Fructus Lycii freckle removing and whitening defying age essence according to claim 1, is characterized in that: described Carbopol 941 first adds water 80 ℃ of left and right stirring and dissolving by weight 1:100, is made into 1% colloidal solution standby.
6. black Fructus Lycii freckle removing and whitening defying age essence according to claim 1, is characterized in that: described solubilizing agent is selected from one or more in HPS, Cremophor RH40, PPG-1-PEG-9 Laurel glycol ethers, PEG-400 Polyethylene Glycol, polyoxyethylated coconut oil alcohol-7, Tween20.
7. black Fructus Lycii freckle removing and whitening defying age essence according to claim 1, is characterized in that: described antibacterial is selected from one or more in germall-BP, extremely U.S. No. II, Kazon, Glydant PLUS.
8. according to the black Fructus Lycii freckle removing and whitening defying age essence described in claim 1～7 any one, it is characterized in that: it is that raw material by following percentage by weight is prepared from:
9. the preparation method of black Fructus Lycii freckle removing and whitening defying age essence described in claim 1～8 any one, is characterized in that: it comprises the steps:
(1) Carbopol 941 is added to water stirring and dissolving at the temperature of 80 ℃ of left and right by weight 1:100, be made into 1% colloidal solution standby;
(2) hyaluronic acid, allantoin, glycerol, 1,3 butylene glycol, disodiumedetate, methyl hydroxybenzoate, solubilizing agent and water stirring and dissolving at 80～90 ℃ is abundant, form transparent solution;
(3) the Carbopol 941 solution that is 1% by (1) prepared concentration slowly joins in (2) solution, and adds triethanolamine, stirs while adding, and makes to dissolve mix homogeneously;
(4) when solution temperature is down to 40～50 ℃, add antibacterial, black Fructus Lycii extracting solution, Aloe extraction solution, seaweed extracted liquor, essence, stir, obtain black Fructus Lycii freckle removing and whitening defying age essence.
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| CN104940038A (en) * | 2015-05-28 | 2015-09-30 | 秦春哲 | Application of lycium ruthenicum anthocyanin in preparation of cosmetic and cosmetic containing lycium ruthenicum anthocyanin |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991709A (en) * | 2010-11-09 | 2011-03-30 | 中国科学院西北高原生物研究所 | Method for preparing antioxidant lycium ruthenicum extract |
-
2013
- 2013-11-06 CN CN201310557661.XA patent/CN103565699B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101991709A (en) * | 2010-11-09 | 2011-03-30 | 中国科学院西北高原生物研究所 | Method for preparing antioxidant lycium ruthenicum extract |
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| CN106880565B (en) * | 2017-03-03 | 2019-11-22 | 北京华奥光程化妆品有限公司 | A kind of plant extracts and its preparation method and application for the light spot of skin-whitening |
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Effective date of registration: 20161010 Address after: 810000 Qinghai biological science and Technology Industrial Park, Qinghai, Xining Province, No. four, No. 22, No. three, C District Patentee after: QINGHAI NUOLANQI BIOTECHNOLOGY DEVELOPMENT CO., LTD. Address before: 810001 Qinghai province Xining City West Street No. 59 Patentee before: Northwest Institute of Plateau Biology, Chinese Academy of Sciences |
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