CN106074190B - A kind of anti-aging visage block cream and preparation method thereof - Google Patents
A kind of anti-aging visage block cream and preparation method thereof Download PDFInfo
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Abstract
The invention belongs to cosmetic technical field, it is related to a kind of anti-aging visage block cream and preparation method thereof.Anti-aging visage block cream of the present invention is by mass percentage, it is grouped as by following group: composite liposome body 10-20%, ascorbic acid glucoside 0.2-0.8%, cetearyl glucoside/cetanol-stearyl alcohol 4-5%, chitosan 0.2-1%, Glydant Plus Liquid0.05-0.2%, Folium Ilicis Purpureae extracting solution 5-10%, isopropyl palmitate 2-5%, jojoba oil 5-8%, xanthan gum 0.1-0.2%, essence 0.01-0.1%, surplus are deionized water.Anti-aging visage block cream property of the present invention is stablized, action temperature and no skin irritation, with significant sun-proof isolation and anti-aging Bearberry Extract.
Description
Technical field
The invention belongs to cosmetic technical field, it is related to a kind of anti-aging visage block cream and preparation method thereof.
Background technique
Among modern city, solarization, haze, radiation, color make-up etc. are ubiquitous to the injury of skin, cause various skins
Problem, if skin is intense darkness without light, skin elasticity is reduced, color spot, wrinkle, acne etc..Skin is quick as caused by non-genetic factor
Sense phenomenon is more and more, and demand of the people to protective cosmetics is also just come into being, after facial treatment milk, toner, foundation cream
After liquid and suncream, sun screen has become one of the cosmetics of modern female indispensability.
Sun screen in the market usually with sun-proof, isolation color make-up and bright color as the main purpose, part also has certain
Moisturizing effect.Chinese patent application 201510295168.4 discloses a kind of natural spiral seaweed sun screen, in formula
It is sweet that raw material and weight ratio are respectively as follows: 1 part of lanolin, 8 parts of fatty alcohol, 4 parts of isopropyl palmitate, 6 parts of atoleine, monostearate
3 parts of grease, 1 part of albolene, 600.5 parts of this disk, 30 parts of spirulina extract, 13 parts of glycerol, (400) 0.5 parts of polyethylene glycol,
Appropriate essence, Preservative qs, appropriate triethanolamine, deionized water add to 100 parts.Using effect experiment shows the natural spiral shell
Algae sun screen is revolved to no skin irritation, obviously feels comfortable after use, is soft, and no greasy feeling is ultraviolet with being significantly isolated
Line prevents and treats the effect of chafing.
102488627 B of Chinese patent CN discloses a kind of anti-radiation moisturizing sun screen, each component and mass fraction are as follows:
Avenabeta glucosan 2-5%, benzophenone-3 2-3%, Sodium Hyaluronate 4%, Butyrospermum parkii fruit oil 3%, dimethyl siloxane
2%, fatty alcohol ether -61%, fatty alcohol ether -251%, Vitwas E 1%, Gotu Kola P.E 0.3%, Curacao reed
Luxuriant growth leaf extract 0.2%, essence 0.2%, xanthan gum 0.1%, methylchloroisothiazandnone 0.1%, dried tremella extract 0.05%,
Cortex Mori extract 1%, surplus are water.The sun screen has sun-proof and moistening effect, while can enhance the anti-spoke of skin entirety
Penetrate ability and immunity.
Currently, from the point of view of the ingredient of commercially available sun screen, the effect of most of sun screens, is still relatively simple, and with sun screen
It is received and is used by more and more women, the new application for continuing to research and develop sun screen becomes the new trend that sun screen develops.Mesh
Before, some sun screens can promote skin smooth texture by the way that silicon compound, mica and light modification particle etc. is added on the market
Ingredient and pigment particles, the modification pore and the adjustment of skin color and other effects with sun screen, but this method can not
The problems such as solving the dim original skin of skin, color spot and wrinkle, long-time service also will further result in skin problem deterioration.Cause
This, needs to research and develop out one kind in addition to protecting isolating function, also has anti-aging white-skinned face function, can fundamentally improve flesh
The sun screen of skin problem.
Summary of the invention
It is an object of the invention to overcome existing technological deficiency, a kind of anti-aging visage block cream is provided.The present invention mentions
The anti-aging visage block cream of confession uses liposome technology, and by the synergistic effect of each component, can effectively maintain each ingredient
Activity and promote absorption of the skin to each active constituent, improve its bioavilability.Anti-aging visage block cream of the present invention
Matter is stablized, action temperature and no skin irritation, with significant sun-proof isolation and anti-aging Bearberry Extract.
Technical scheme is as follows:
A kind of anti-aging visage block cream is grouped as by following group by mass percentage: composite liposome body 10-
20%, ascorbic acid glucoside 0.2-0.8%, cetearyl glucoside/cetanol-stearyl alcohol 4-5%, chitosan 0.2-
1%, Glydant Plus Liquid 0.05-0.2%, Folium Ilicis Purpureae extracting solution 5-10%, isopropyl palmitate 2-5%, suddenly
Bar oil 5-8% suddenly, xanthan gum 0.1-0.2%, essence 0.01-0.1%, surplus is deionized water；
Wherein, the composite liposome body according to parts by weight, is grouped as by following group: 5-10 parts of dandelion extract,
8-15 parts of woods grass extract of hiding, 1-5 parts of avenabeta glucosan, 0.001-0.01 parts of growth factor, wheat gluten zymolyte 10-20
Part, 70-150 parts of hydrolecithin, 15-30 parts and cholesterol 8-20 parts of Tween 80.
Further, it is raw to be selected from acid fibroblast growth factor aFGF, basic fibroblast for the growth factor
One of long factor bFGF, epidermal growth factor EGF, keratinocyte growth factor KGF and stem cell factor SCGF or
It is a variety of.
Further, the anti-aging visage block cream by mass percentage, is grouped as: composite liposome by following group
Body 16%, ascorbic acid glucoside 0.4%, cetearyl glucoside/cetanol-stearyl alcohol 4.5%, chitosan 0.8%,
Glydant Plus Liquid 0.15%, Folium Ilicis Purpureae extracting solution 8%, isopropyl palmitate 4%, jojoba oil 6%, xanthan
Glue 0.1%, essence 0.05% and deionized water 60%；
Wherein, the composite liposome body according to parts by weight, is grouped as by following group: 8 parts of dandelion extract, hiding woods
10 parts of careless extract, 0.006 part of epidermal growth factor, 12 parts of wheat gluten zymolyte, hydrogenates lecithin by 3 parts of avenabeta glucosan
120 parts of rouge, 24 parts and 15 parts of cholesterol of Tween 80.
Further, the dandelion extract the preparation method comprises the following steps: take dandelion, crushed after clean dry, cross 40-60
Mesh is added 10-15 times of its quality and measures ethyl alcohol extraction 2-3 times, each 1-2h that volume fraction is 80-95%, and filtering merges filter
Liquid, vacuum distillation remove ethyl alcohol, the concentrate that 60 DEG C of lower densities are 1.0-1.05 are concentrated under reduced pressure into, by concentrate 1200-
1500r/min is centrifuged 10-20min, and supernatant is taken to carry out ultrafiltration, ultrafiltration with the PS membrane that molecular cut off is 10000-30000
It is 1.20-1.30 that liquid, which is concentrated under reduced pressure into relative density at 60 DEG C, and spray drying obtains dandelion extract.
Further, the hiding woods grass extract the preparation method comprises the following steps: take Zang Lincao, crushed after clean dry, cross 40-60
Water heating and refluxing extraction 2-3 times that 15-20 times of its quality is measured, each 1-2h, filtering, merging filtrate, reduced pressure is added in mesh
To the concentrate that 60 DEG C of lower densities are 1.0-1.05, concentrate 1200-1500r/min is centrifuged 10-20min, supernatant is taken to use
The PS membrane that molecular cut off is 10000-30000 carries out ultrafiltration, and it is 1.20- that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,
1.30, spray drying must hide woods grass extract.
Further, the Folium Ilicis Purpureae extracting solution the preparation method comprises the following steps: take Folium Ilicis Purpureae, crushed after clean dry, mistake
Water heating and refluxing extraction 2-3 times that 10-18 times of its weight is measured is added in 40-60 mesh, and each 1-2h is filtered, merging filtrate,
Filtrate decompression is concentrated into the concentrate that 60 DEG C of relative densities are 1.0-1.05, and 1200-1500r/min is centrifuged 10-20min, takes
Clear liquid carries out ultrafiltration with the PS membrane for being 10000-30000 with molecular cut off, and ultrafiltrate is concentrated under reduced pressure into relatively close at 60 DEG C
Degree is the concentrate of 1.10-1.15 to get Chinese holly extracting solution.
Further, the wheat gluten zymolyte the preparation method comprises the following steps: take gluten powder, its weight 15~20 is added
The water of amount again, stirs evenly, and the pepsin of 1200~1800U/g is added, and is 2.0~4.0 in pH value, temperature is 35~45 DEG C
Under conditions of digest 6~10h, enzymolysis process keeps solution ph constant, and 95 DEG C of 15~20min of enzyme deactivation after enzymatic hydrolysis are cooling
Centrifuging and taking supernatant afterwards is concentrated under reduced pressure, and is spray-dried to get wheat gluten zymolyte.
Further, the preparation method of the composite liposome body includes the following steps:
S1: taking hydrolecithin, Tween 80 and cholesterol, is added to absolute ethanol by solid-to-liquid ratio 2-5mg/mL, stirs molten
Solution, obtains solution I；
S2: by dandelion extract, hiding woods grass extract, avenabeta glucosan, growth factor and wheat gluten zymolyte,
PBS is added by solid-to-liquid ratio 2-5mg/mL, stirring and dissolving obtains solution II；
S3: being added supercritical autoclave for solution II described in solution I described in S1 and S2, is 30-40 DEG C in temperature, pressure is
20-28MPa, CO2Flow emulsifies 30-45min under conditions of being 12-16L/h, and decompression separation emulsification product obtains composite liposome
Body；Wherein, separation temperature is 30-40 DEG C, separating pressure 5-15MPa.
Further, in the preparation method of the composite liposome body, the pH of PBS described in step S2 is 6.8-7.0, concentration
For 0.01-0.03mol/L.
In anti-aging visage block cream of the present invention, using hydrolecithin, Tween 80 and cholesterol as membrane material, with dandelion
Extract, hiding woods grass extract, avenabeta glucosan, growth factor and wheat gluten zymolyte compound are effective component preparation
Obtained composite liposome body can effectively maintain the activity of each ingredient and promote absorption of the skin to each active constituent, improve it
Bioavilability.
In each effective component, dandelion extract and chlorogenic acid rich in hiding woods grass extract, flavonoid
The oxidation-resistant active ingredients such as object, have the effects that the effect of quasi-SOD sample and improve endogenous SOD it is active, subcutaneously can rapidly to from
It is purged by base, while metabolism status of the free radical in skin histology can be improved, so as to effectively block free radical to skin
The damaging action of skin mitigates superoxide radical to the oxygen of the stimulation of skin histology and inflammation damnification and inhibition unsaturated fatty acid
Change process has significant wrinkle resistant, reduction pigmentation and inhibits acne effect；Meanwhile dandelion extract also has relatively by force
Inhibit tyrosinase activity effect, there is significant whitening effect, and hiding woods grass has significant anti-radiation and enhancing immune
The function of system.In addition, dandelion extract, hiding woods grass extract and growth factor, wheat gluten zymolyte are used in compounding, it is right
Growth factor, the activity of wheat gluten zymolyte have good protective effect.
Avenabeta glucosan not only has anti-sunlight function, moreover it is possible to promote langerhans' cells to be proliferated, enhance the immune of skin
Power, can be effectively anti-radiation.Growth factor can effectively facilitate cytothesis and tissue repair, while can promote Skin Cell to nutrition
The absorption of substance, accelerates the metabolism of cell, to promote the synthesis of hyaluronic acid and collagen etc., to reach crease-resistant
And the effect to delay senescence.Wheat gluten zymolyte contains proteins and peptides ingredient abundant, is easy to be absorbed by the skin utilization, right
Skin has preferable skin-moisturizing, skin and antioxidation.Avenabeta glucosan, wheat gluten zymolyte and growth factor have
Positive cooperativity, one side avenabeta glucosan, wheat gluten zymolyte are used in compounding the abundant moisture that can keep skin, thus
Can be very good maintain growth factor bioactivity, another aspect three collaboration can be improved composite liposome body it is each effectively at
The permeability divided, is conducive to absorption of the skin to each active constituent, improves its bioavilability.
In other raw materials of anti-aging visage block cream of the present invention, ascorbic acid glucoside is a kind of vitamin C derivatives, English
Literary fame is known as Ascorbyl Glucoside, has whitening effect, while it is used for anti-aging of the present invention with antioxidation
The stability of sun screen can be improved in visage block cream；Cetearyl glucoside/cetanol-stearyl alcohol, English name are
Cetearyl Glucoside (and) Cetearyl Alcohol is a kind of efficient emulsifier, with anti-aging whitening of the present invention every
There is very high compatibility from other white raw materials, make the sun screen lotion being prepared is fine and smooth, is conducive to raising sun screen to use
When fine and smooth sense and spreadability；Isopropyl palmitate, English name is Isopropyl palmitate, in anti-aging of the present invention
Visage block cream is conducive to increase sun screen screening characteristics as emollient and solubilizer, so that skin is generated soft feeling and increases resistance to
Wiping property；Glydant Plus Liquid is the disinfecting preservative of LONZA company research and development, by fungicide (1,3- dihydroxymethyl
Uride in 5,5- dimethyl second two) and mould inhibitor (the iodo- 2- propine butyl carbamate of 3-) composition, safety and to temperature stablize
Property it is high.
Anti-aging visage block cream provided by the invention formula rationally, stablize by property, action temperature and, no skin irritation,
And by the synergistic effect of various effective components, there is significant sun-proof isolation and anti-aging Bearberry Extract.
Correspondingly, the present invention also provides a kind of preparation methods of anti-aging visage block cream of the present invention, including such as
Lower step:
1) oil cauldron is added in cetearyl glucoside/cetanol-stearyl alcohol, isopropyl palmitate and jojoba oil
In, it is heated to 75-85 DEG C, constant temperature is stirred to being completely dissolved, and obtains material A；
2) ascorbic acid glucoside, chitosan, xanthan gum and water are added in emulsion pot, are heated to 75-85 DEG C, perseverance
Temperature stirring obtains material B to being completely dissolved；
3) material A is slowly added in material B, carries out emulsifying, speed of agitator 2500-3000r/min, homogenized milk
The change time is 8-15min, and vacuum defoamation obtains emulsion I；
4) object I to be emulsified is cooled to 40-45 DEG C, and composite liposome body, Glydant Plus Liquid, Chinese holly is added
Leaf extract and essence carry out second of emulsifying, speed of agitator 500-700r/min, and the emulsifying time is 2-
5min, vacuum defoamation are cooled to room temperature, to plate, qualification discharging to get.
Compared with prior art, the beneficial effects of the present invention are:
1) anti-aging visage block cream provided by the invention uses liposome technology, and passes through the association of various active constituents
Same-action can effectively maintain the activity of each ingredient and promote absorption of the skin to each active constituent, improve its bioavilability；
2) anti-aging visage block cream formula provided by the invention is reasonable, the anti-aging visage block cream property being prepared
Stablize, action temperature and no skin irritation, with significant sun-proof isolation and anti-aging Bearberry Extract；
3) provided by the invention simple containing anti-aging visage block cream preparation method of the present invention, process stabilizing is convenient to carry out,
Can industrialized production, be conducive to promote and apply.
Specific embodiment
The present invention is further described below by way of specific embodiment, but the present invention is not limited only to following embodiment.This
In inventive embodiments unless otherwise instructed, it is raw materials used be it is commercially available, such as avenabeta glucosan, Tween 80, Glydant Plus
Liquid and jojoba oil are purchased from Guangzhou Chen Qian Chemical Co., Ltd..
The preparation of 1 dandelion extract of embodiment
Dandelion is taken, is crushed after clean dry, 60 meshes are crossed, the ethyl alcohol that 12 times of its quality amount volume fractions are 85% is added
It extracts 2 times, each 1h, filtering, merging filtrate, vacuum distillation removes ethyl alcohol, is concentrated under reduced pressure into the concentration that 60 DEG C of lower densities are 1.0
Concentrate 1200r/min is centrifuged 15min, supernatant is taken to carry out ultrafiltration with the PS membrane that molecular cut off is 20000, surpassed by liquid
It is 1.20 that filtrate decompression, which is concentrated into relative density at 60 DEG C, and spray drying obtains dandelion extract.
The preparation of the hiding of embodiment 2 woods grass extract
Zang Lincao is taken, is crushed after clean dry, 60 meshes are crossed, water heating and refluxing extraction 2 times of 15 times of its quality amounts are added,
Each 2h, filtering, merging filtrate are concentrated under reduced pressure into the concentrate that 60 DEG C of lower densities are 1.0, concentrate 1200r/min are centrifuged
15min takes supernatant to carry out ultrafiltration with the PS membrane that molecular cut off is 20000, and ultrafiltrate is concentrated under reduced pressure at 60 DEG C relatively
Density is 1.20, and spray drying must hide woods grass extract.
The preparation of 3 Folium Ilicis Purpureae extracting solution of embodiment
Folium Ilicis Purpureae is taken, is crushed after clean dry, 60 meshes are crossed, the water heating and refluxing extraction of 16 times of its weight amounts is added
2 times, each 2h, filtering, merging filtrate, filtrate decompression be concentrated into 60 DEG C of relative densities be 1.0 concentrate, 1200r/min from
Heart 15min takes supernatant to carry out ultrafiltration with the PS membrane for being 20000 with molecular cut off, and ultrafiltrate is concentrated under reduced pressure at 60 DEG C
The concentrate that relative density is 1.15 is to get Chinese holly extracting solution.
The preparation of 4 wheat gluten zymolyte of embodiment
Gluten powder is taken, the water of 15 times of its weight amounts is added, stirs evenly, the pepsin of 1500U/g is added, in pH
Value is 3.5, and temperature digests 8h under conditions of being 40 DEG C, and enzymolysis process keeps solution ph constant, 95 DEG C of enzyme deactivations after enzymatic hydrolysis
15min, centrifuging and taking supernatant after cooling are concentrated under reduced pressure, and are spray-dried to get wheat gluten zymolyte.
The preparation of 5 composite liposome body of embodiment
The present embodiment composite liposome body according to parts by weight, is grouped as by following group: 8 parts of dandelion extract, hiding woods
10 parts of careless extract, 3 parts of avenabeta glucosan, 0.006 part of EGF, 12 parts of wheat gluten zymolyte, 120 parts of hydrolecithin,
24 parts and 15 parts of cholesterol of Tween 80.
Preparation method:
S1: taking hydrolecithin, Tween 80 and cholesterol, is added to absolute ethanol by solid-to-liquid ratio 3mg/mL, stirring and dissolving,
Obtain solution I；
S2: by dandelion extract, hiding woods grass extract, avenabeta glucosan, EGF and wheat gluten zymolyte, by solid
It is 6.8 that pH, which is added, in liquor ratio 3.5mg/mL, and concentration is the PBS of 0.02mol/L, and stirring and dissolving obtains solution II；
S3: being added supercritical autoclave for solution II described in solution I described in S1 and S2, is 40 DEG C in temperature, pressure is
25MPa, CO2Flow emulsifies 30min under conditions of being 15L/h, and decompression separation emulsification product obtains composite liposome body；Wherein, divide
It is 40 DEG C from temperature, separating pressure 8MPa.
The preparation of 6 composite liposome body of embodiment
The present embodiment composite liposome body according to parts by weight, is grouped as by following group: 10 parts of dandelion extract, hiding woods
8 parts of careless extract, 2 parts of avenabeta glucosan, 0.007 part of bFGF, 0.001 part of EGF, 18 parts of wheat gluten zymolyte, hydrogenation
150 parts of lecithin, 30 parts and 18 parts of cholesterol of Tween 80.
Preparation method:
S1: taking hydrolecithin, Tween 80 and cholesterol, is added to absolute ethanol by solid-to-liquid ratio 4mg/mL, stirring and dissolving,
Obtain solution I；
S2: by dandelion extract, hiding woods grass extract, avenabeta glucosan, bFGF, EGF and wheat gluten zymolyte,
It is 6.8 that pH, which is added, by solid-to-liquid ratio 3.5mg/mL, and concentration is the PBS of 0.03mol/L, and stirring and dissolving obtains solution II；
S3: being added supercritical autoclave for solution II described in solution I described in S1 and S2, is 30 DEG C in temperature, pressure is
20MPa, CO2Flow emulsifies 45min under conditions of being 12L/h, and decompression separation emulsification product obtains composite liposome body；Wherein, divide
It is 30 DEG C from temperature, separating pressure 10MPa.
The preparation of the anti-aging visage block cream of the present invention of embodiment 7
The present embodiment anti-aging visage block cream is grouped as by following group by mass percentage: 5 compound of embodiment
Liposome 10%, ascorbic acid glucoside 0.2%, cetearyl glucoside/cetanol-stearyl alcohol 4%, chitosan
0.2%, Glydant Plus Liquid 0.1%, Folium Ilicis Purpureae extracting solution 5%, isopropyl palmitate 2%, jojoba oil
5%, xanthan gum 0.1%, essence 0.01% and deionized water 73.39%.
Preparation method:
1) oil cauldron is added in cetearyl glucoside/cetanol-stearyl alcohol, isopropyl palmitate and jojoba oil
In, 80 DEG C are heated to, constant temperature is stirred to being completely dissolved, and obtains material A；
2) ascorbic acid glucoside, chitosan, xanthan gum and water are added in emulsion pot, are heated to 80 DEG C, constant temperature
Stirring obtains material B to being completely dissolved；
3) material A is slowly added in material B, carries out emulsifying, speed of agitator 3000r/min, when emulsifying
Between be 10min, vacuum defoamation obtains emulsion I；
4) object I to be emulsified is cooled to 40 DEG C, and composite liposome body, Glydant Plus Liquid, Folium Ilicis Purpureae is added and mentions
It taking liquid and essence, carries out second of emulsifying, speed of agitator 600r/min, the emulsifying time is 3min, vacuum defoamation,
Be cooled to room temperature, to plate, qualification discharging to get.
The preparation of the anti-aging visage block cream of the present invention of embodiment 8
The present embodiment anti-aging visage block cream is grouped as by following group by mass percentage: 6 compound of embodiment
Liposome 20%, ascorbic acid glucoside 0.8%, cetearyl glucoside/cetanol-stearyl alcohol 5%, chitosan 1%,
Glydant Plus Liquid 0.05%, Folium Ilicis Purpureae extracting solution 10%, isopropyl palmitate 5%, jojoba oil 8% are yellow
Virgin rubber 0.2%, essence 0.1% and deionized water 49.85%.
Preparation method is the same as embodiment 7.
The preparation of the anti-aging visage block cream of the present invention of embodiment 9
The present embodiment anti-aging visage block cream is grouped as by following group by mass percentage: 5 compound of embodiment
Liposome 16%, ascorbic acid glucoside 0.4%, cetearyl glucoside/cetanol-stearyl alcohol 4.5%, chitosan
0.8%, Glydant Plus Liquid 0.15%, Folium Ilicis Purpureae extracting solution 8%, isopropyl palmitate 4%, jojoba oil
6%, xanthan gum 0.1%, essence 0.05% and deionized water 60%.
Preparation method is the same as embodiment 7.
Comparative example 1
1) it prepares composite liposome body: according to parts by weight, being grouped as by following group: 8 parts of Gotu Kola P.E, Zang Lincao
It 10 parts of extract, 3 parts of avenabeta glucosan, 0.006 part of EGF, 12 parts of wheat gluten zymolyte, 120 parts of hydrolecithin, spits
8024 parts and 15 parts of cholesterol of temperature.
That the preparation method is the same as that of Example 1 is similar for Gotu Kola P.E, and the preparation method of complex liposome is similar with embodiment 5.
2) it prepares sun screen: by mass percentage, being grouped as by following group: the composite liposome body of this comparative example preparation
16%, ascorbic acid glucoside 0.4%, cetearyl glucoside/cetanol-stearyl alcohol 4.5%, chitosan 0.8%,
Glydant Plus Liquid 0.15%, Folium Ilicis Purpureae extracting solution 8%, isopropyl palmitate 4%, jojoba oil 6%, xanthan
Glue 0.1%, essence 0.05% and deionized water 60%.
Preparation method is similar with embodiment 9.
Comparative example 1 and the difference of embodiment 9 are, replace dandelion to mention with Gotu Kola P.E in the complex liposome
Take object.
Comparative example 2
1) it prepares composite liposome body: according to parts by weight, being grouped as by following group: 18 parts of dandelion extract, oat
3 parts of beta glucan, 0.006 part of EGF, 12 parts of wheat gluten zymolyte, 120 parts of hydrolecithin, 24 parts of Tween 80 and cholesterol
15 parts.
Preparation method is similar with embodiment 5.
2) it prepares sun screen: by mass percentage, being grouped as by following group: the composite liposome body of this comparative example preparation
16%, ascorbic acid glucoside 0.4%, cetearyl glucoside/cetanol-stearyl alcohol 4.5%, chitosan 0.8%,
Glydant Plus Liquid 0.15%, Folium Ilicis Purpureae extracting solution 8%, isopropyl palmitate 4%, jojoba oil 6%, xanthan
Glue 0.1%, essence 0.05% and deionized water 60%.
Preparation method is similar with embodiment 9.
Comparative example 2 and the difference of embodiment 9 are that dandelion extract content improves in the complex liposome, are free of
Hide woods grass extract.
Comparative example 3
1) it prepares composite liposome body: according to parts by weight, being grouped as by following group: 8 parts of dandelion extract, Zang Lincao
10 parts of extract, 8 parts of avenabeta glucosan, 0.006 part of EGF, 120 parts of hydrolecithin, 24 parts of Tween 80 and cholesterol 15
Part.
The preparation method of complex liposome is similar with embodiment 5.
2) it prepares sun screen: by mass percentage, being grouped as by following group: the composite liposome body of this comparative example preparation
16%, ascorbic acid glucoside 0.4%, cetearyl glucoside/cetanol-stearyl alcohol 4.5%, chitosan 0.8%,
Glydant Plus Liquid 0.15%, Folium Ilicis Purpureae extracting solution 8%, isopropyl palmitate 4%, jojoba oil 6%, xanthan
Glue 0.1%, essence 0.05% and deionized water 60%.
Preparation method is similar with embodiment 9.
Comparative example 3 and the difference of embodiment 9 are that the content of avenabeta glucosan improves in the complex liposome, no
Zymolyte containing wheat gluten.
The evaluation of one product index of test example
1, the relevant criterion of reference People's Republic of China's light industry professional standard QB/T 1857-2013 " moisturizing cream ",
The anti-aging visage block cream that 7-9 of the embodiment of the present invention is prepared is tested, the results are shown in Table 1.
The anti-aging visage block cream sense organ of the present invention of table 1, physics and chemistry, sanitary index test result
2, referring to the related request of " human skin patch " in the Ministry of Public Health " cosmetics health specification " (version in 2007)
Present invention implementation 7-9, comparative example the 1-3 sun screen being prepared are tested with measuring method, the experimental results showed that implementing
The sun screen that 7-9, comparative example 1-3 are prepared is without skin adverse reaction.
The measurement of the anti-aging visage block cream SPF of the present invention of test example two
Referring to " sunscreen cosmetic SPF (spf value) measurement in the Ministry of Public Health " cosmetics health specification " (version in 2007)
The related request and measuring method of method " carry out.Given the test agent be 7-9 of the embodiment of the present invention, comparative example 1-3 be prepared every
From frost.It chooses 90 trial volunteers to test, is randomly divided into 6 groups, every group of 15 people.
After the test, each aspiration subject is asked to carry out the greasy feeling of sun screen, fine and smooth sense, residual and spreadability etc.
Evaluation.
The 2 sun-proof the performance test results of sun screen of the present invention of table
| Group | Embodiment 7 | Embodiment 8 | Embodiment 9 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Spf value | 16 | 15 | 18 | 9 | 6 | 10 |
It can be seen that sun screen spf value that 7-8 of the embodiment of the present invention is prepared 15 or more from the test result of table 2,
Illustrate that anti-aging visage block cream provided by the invention has good barrier and absorbent properties to ultraviolet light, sun-proof result is good.
Sun screen sun-proof result provided by the invention is substantially better than comparative example group, meanwhile, from test result as can be seen that embodiment 9 is
Highly preferred embodiment of the present invention.
It is fed back through each aspiration subject, without greasy feeling in anti-aging visage block cream use process of the present invention, skin absorbs
Effect, fine and smooth sense and spreadability are preferable.
The evaluation of the anti-aging visage block cream anti-aging effects of the present invention of test example three
1, given the test agent: the sun screen that 7-9 of the embodiment of the present invention, comparative example 1-3 are prepared.
2, kunming mice 70 of health, 9-11 week old, weight 35-45g, half male and half female experimental animal: are taken.By weight with
Machine is divided into blank control group, embodiment 7-8 group and comparative example 1-3 group, and every group 10.
3, test method: each group mouse is lost hair or feathers with 0.8% vulcanized sodium back, the test section of exposure 4cm × 4cm.It smears
Skin first is cleaned with warm water before sun screen, each daily morning and evening to smear primary corresponding sun screen, wherein blank control group smears life
Salt water is managed, it is continuous to smear 30 days, the mouse hair newly grown is during which shaved off in time.After last smears 12h, clip mouse test section skin
Tissue, prepares skin histology homogenate, with kit measurement superoxide dismutase (SOD) vigor and malonaldehyde (MDA) content.
Test result is shown in Table 3.
Influence of the anti-aging visage block cream of the present invention of table 3 to MDA, SOD content in skin histology homogenate
| Group | MDA(nmol/mgprot) | SOD(U/mgprot) |
| Blank control group | 3.72±0.65 | 126.42±17.68 |
| 7 groups of embodiment | 2.78±0.26* | 165.30±20.76* |
| 8 groups of embodiment | 2.88±0.38* | 163.56±19.52* |
| 9 groups of embodiment | 2.64±0.38* | 167.35±18.68* |
| 1 group of comparative example | 3.18±0.42 | 150.81±25.56 |
| 2 groups of comparative example | 3.24±0.32 | 146.63±24.14 |
| 3 groups of comparative example | 3.56±0.75 | 138.84±20.63 |
Note: compared with blank control group,*P < 0.05.
As seen from the results in Table 3,7-9 of embodiment of the present invention anti-aging visage block cream is remarkably improved the work of SOD in skin
Power reduces the content of MDA, illustrates that anti-aging visage block cream provided by the invention has good anti-aging effects, wherein real
The effect for applying example 9 is the most significant, is preferred embodiment.Compared with 9 groups of embodiment of sun screen, comparative example 1-3 group every
Anti-aging effects from frost are undesirable, illustrate anti-aging visage block cream each component collaboration of the present invention.
The evaluation of the anti-aging visage block cream whitening effect of the present invention of test example four
1, given the test agent: the sun screen that 7-8 of the embodiment of the present invention, comparative example 1-3 are prepared.
2, test method: choosing 180 women trial volunteers participation and test, and the age 25-40 years old, volunteer's exclusion condition
Meet " cosmetics contact dermatitis diagnostic criteria and treatment principle " to be included in, exclusion criteria.Test position is inside of cranking arm, at random
Arranging left and right arm is tested area, before test, utilizes dermal melanin and ferroheme tester (Mexameter MX18, moral CK
Company's production) each trial volunteer's recipient site dermal melanin content MI value of test, according to MI value by all trial volunteers
It is randomly divided into embodiment 7-9,6 groups of comparative example 1-3 group, every group of 30 people.Then each group trial volunteer use respectively accordingly by
Test agent, it is sooner or later each to apply once, it is used continuously 8 weeks, recipient site does not use other cosmetics during test.Utilize skin black
Element and ferroheme tester test dermal melanin content MI value after each trial volunteer's recipient site test.Test skin black
It needs to clean recipient site before cellulose content MI value.Test result is shown in Table 4.
Influence of the anti-aging visage block cream of the present invention of table 4 to dermal melanin content MI value
| Group | Before test | After test |
| 7 groups of embodiment | 216.64±42.64 | 189.62±28.86** |
| 8 groups of embodiment | 219.03±40.42 | 196.63±31.36* |
| 9 groups of embodiment | 218.54±38.76 | 183.38±27.62** |
| 1 group of comparative example | 216.95±43.38 | 210.54±38.23 |
| 2 groups of comparative example | 216.74±40.22 | 206.98±36.89 |
| 3 groups of comparative example | 217.38±36.95 | 204.52±40.27 |
Note: compared with before test,*P < 0.05,**P < 0.05.
As can be known from the results of Table 4, it is black can to significantly reduce skin for the anti-aging visage block cream of 7-9 of embodiment of the present invention preparation
Pigment content MI value illustrates that anti-aging visage block cream provided by the invention has significant whitening effect.Comparative example 1-3 group will
Though being willing to that the dermal melanin content MI value of subject is declined, compared with before test, no significant difference illustrates comparative example 1-
The whitening effect of 3 sun screens is undesirable, not as good as the sun screen that the present invention is prepared, illustrates anti-aging visage block cream of the present invention
Each component collaboration.
The above content is a further detailed description of the present invention in conjunction with specific preferred embodiments, and it cannot be said that
Specific implementation of the invention is only limited to these instructions.For those of ordinary skill in the art to which the present invention belongs, exist
Under the premise of not departing from present inventive concept, a number of simple deductions or replacements can also be made, all shall be regarded as belonging to of the invention
Protection scope.
Claims (9)
1. a kind of anti-aging visage block cream, which is characterized in that the anti-aging visage block cream by mass percentage, by such as
The following group is grouped as: composite liposome body 10-20%, ascorbic acid glucoside 0.2-0.8%, cetearyl glucoside/whale
Ceryl alcohol-stearyl alcohol 4-5%, chitosan 0.2-1%, Glydant Plus Liquid 0.05-0.2%, Folium Ilicis Purpureae extracting solution
5-10%, isopropyl palmitate 2-5%, jojoba oil 5-8%, xanthan gum 0.1-0.2%, essence 0.01-0.1%, surplus are
Deionized water；
Wherein, the composite liposome body according to parts by weight, is grouped as by following group: 5-10 parts of dandelion extract, hiding woods
Careless extract 8-15 parts, 1-5 parts of avenabeta glucosan, 0.001-0.01 parts of growth factor, 10-20 parts of wheat gluten zymolyte,
70-150 parts of hydrolecithin, 15-30 parts and cholesterol 8-20 parts of Tween 80；
The preparation method of the composite liposome body includes the following steps:
S1: taking hydrolecithin, Tween 80 and cholesterol, is added to absolute ethanol by solid-to-liquid ratio 2-5mg/mL, and stirring and dissolving obtains
Solution I；
S2: by dandelion extract, hiding woods grass extract, avenabeta glucosan, growth factor and wheat gluten zymolyte, by solid
PBS is added in liquor ratio 2-5mg/mL, and stirring and dissolving obtains solution II；
S3: being added supercritical autoclave for solution II described in solution I described in S1 and S2, is 30-40 DEG C in temperature, pressure 20-
28MPa, CO2Flow emulsifies 30-45min under conditions of being 12-16L/h, and decompression separation emulsification product obtains composite liposome body；
Wherein, separation temperature is 30-40 DEG C, separating pressure 5-15MPa.
2. anti-aging visage block cream as described in claim 1, which is characterized in that the growth factor is selected from acid fibroblast
Porcine HGF, basic fibroblast growth factor, epidermal growth factor, keratinocyte growth factor and stem cell growth
One of factor is a variety of.
3. anti-aging visage block cream as described in claim 1, which is characterized in that the anti-aging visage block cream presses quality
Percentages are grouped as by following group: composite liposome body 16% as described in claim 1, ascorbic acid glucoside
0.4%, cetearyl glucoside/cetanol-stearyl alcohol 4.5%, chitosan 0.8%, Glydant Plus Liquid
0.15%, Folium Ilicis Purpureae extracting solution 8%, isopropyl palmitate 4%, jojoba oil 6%, xanthan gum 0.1%, 0.05% He of essence
Deionized water 60%；
Wherein, the composite liposome body according to parts by weight, is grouped as by following group: 8 parts of dandelion extract, Zang Lincao is mentioned
Take 10 parts of object, 3 parts of avenabeta glucosan, 0.006 part of epidermal growth factor, 12 parts of wheat gluten zymolyte, hydrolecithin 120
Part, 24 parts and 15 parts of cholesterol of Tween 80.
4. anti-aging visage block cream as described in claim 1, which is characterized in that the preparation method of the dandelion extract
Are as follows: dandelion is taken, is crushed after clean dry, 40-60 mesh is crossed, it is 80-95%'s that 10-15 times of its quality, which is added, and measures volume fraction
Ethyl alcohol extracts 2-3 times, each 1-2h, filtering, merging filtrate, and vacuum distillation removes ethyl alcohol, and being concentrated under reduced pressure into 60 DEG C of lower densities is
Concentrate 1200-1500r/min is centrifuged 10-20min, takes the supernatant to be with molecular cut off by the concentrate of 1.0-1.05
The PS membrane of 10000-30000 carries out ultrafiltration, and it is 1.20-1.30 that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C, spraying dry
It is dry, obtain dandelion extract.
5. anti-aging visage block cream as described in claim 1, which is characterized in that the preparation method of the hiding woods grass extract
Are as follows: Zang Lincao is taken, is crushed after clean dry, 40-60 mesh is crossed, the water heating and refluxing extraction 2-3 that 15-20 times of its quality is measured is added
Secondary, each 1-2h is filtered, merging filtrate, the concentrate that 60 DEG C of lower densities are 1.0-1.05 is concentrated under reduced pressure into, by concentrate
1200-1500r/min is centrifuged 10-20min, and supernatant is taken to carry out ultrafiltration with the PS membrane that molecular cut off is 10000-30000,
It is 1.20-1.30 that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C, and spray drying must hide woods grass extract.
6. anti-aging visage block cream as described in claim 1, which is characterized in that the preparation side of the Folium Ilicis Purpureae extracting solution
Method are as follows: take Folium Ilicis Purpureae, crushed after clean dry, cross 40-60 mesh, the water that 10-18 times of its weight is measured is added is heated to reflux and mention
It taking 2-3 times, each 1-2h, filters, merging filtrate, filtrate decompression is concentrated into the concentrate that 60 DEG C of relative densities are 1.0-1.05,
1200-1500r/min is centrifuged 10-20min, and supernatant is taken to be surpassed with the PS membrane for being 10000-30000 with molecular cut off
Filter, it is the concentrate of 1.10-1.15 to get Chinese holly extracting solution that ultrafiltrate, which is concentrated under reduced pressure into relative density at 60 DEG C,.
7. anti-aging visage block cream as described in claim 1, which is characterized in that the preparation side of the wheat gluten zymolyte
Method are as follows: take gluten powder, the water of 15~20 times of its weight amounts is added, stirs evenly, the stomach cardia of 1200~1800U/g is added
Enzyme is 2.0~4.0 in pH value, and temperature digests 6~10h under conditions of being 35~45 DEG C, enzymolysis process keeps solution ph not
Become, 95 DEG C of 15~20min of enzyme deactivation after enzymatic hydrolysis, centrifuging and taking supernatant after cooling is concentrated under reduced pressure, and is spray-dried to get wheat
Protein zymolyte.
8. anti-aging visage block cream as described in claim 1, which is characterized in that the preparation method of the composite liposome body
In, the pH of PBS described in step S2 is 6.8-7.0, concentration 0.01-0.03mol/L.
9. a kind of preparation method of anti-aging visage block cream a method as claimed in any one of claims 1-8, which is characterized in that described anti-
The preparation method of aging visage block cream includes the following steps:
1) cetearyl glucoside/cetanol-stearyl alcohol, isopropyl palmitate and jojoba oil are added in oil cauldron, are added
Heat is warming up to 75-85 DEG C, and constant temperature is stirred to being completely dissolved, and obtains material A；
2) ascorbic acid glucoside, chitosan, xanthan gum and water are added in emulsion pot, are heated to 75-85 DEG C, constant temperature stirs
It mixes to being completely dissolved, obtains material B；
3) material A is slowly added in material B, carries out emulsifying, speed of agitator 2500-3000r/min, when emulsifying
Between be 8-15min, vacuum defoamation obtains emulsion I；
4) object I to be emulsified is cooled to 40-45 DEG C, and composite liposome body, Glydant Plus Liquid, Folium Ilicis Purpureae is added and mentions
Liquid and essence are taken, second of emulsifying, speed of agitator 500-700r/min are carried out, the emulsifying time is 2-5min, very
Empty deaeration, is cooled to room temperature, to plate, qualification discharging to get.
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| CN108324674A (en) * | 2018-03-26 | 2018-07-27 | 广东巴松那生物科技有限公司 | A kind of creme of cosmetic complex and preparation method thereof containing actin |
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